BGC0000819 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000819 (Penicillium fellutanum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	47,884	paraherquamide	NRPS:Type I+other:other	100%

BGC0000819 - Region 1 - NRPS,indole

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Location: 1 - 47,884 nt. (total: 47,884 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 47,885
Label		BGC0000819

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000819	1.43	NRP, Alkaloid	paraherquamide	Penicillium fellutanum
BGC0002199	0.51	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0000811	0.50	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0002555	0.45	NRP, Polyketide	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.
BGC0001718	0.42	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000816	0.40	NRP, Alkaloid	malbrancheamide A	Malbranchea aurantiaca
BGC0002242	0.38	NRP	oxepinamide D	Aspergillus ustus
BGC0002166	0.37	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0002164	0.37	NRP	peramine	Epichloe festucae
BGC0000293	0.37	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000819	1.00	NRP, Alkaloid	paraherquamide	Penicillium fellutanum
BGC0000687	0.66	Terpene	phyllocladan-16α-ol	Diaporthe amygdali
BGC0002610	0.65	Terpene	stellatic acid	Aspergillus stellatus
BGC0002736	0.65	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002219	0.64	Terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000685	0.63	Terpene	brassicicene C	Alternaria brassicicola ATCC 96836
BGC0000631	0.63	Terpene	botcinin H, botcinin I, botcinin J, cinbotolide D, botcinin K	Botrytis cinerea B05.10
BGC0001260	0.63	Terpene	terpendole E	Tolypocladium album
BGC0001775	0.62	Terpene	sespendole	Cordana terrestris
BGC0001547	0.62	Terpene	citreohybridonol	Aspergillus stellatus

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

NRPS/PKS substrate predictions

phqB

Search NORINE for peptide: strict or relaxed

AMP-binding (251..654): X

nrpys: 4Me-Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DMIFTGLPAK
Nearest Stachelhaus code(s):: 4Me-Pro DMIFTGLPAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1356..1758): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DSVCVVGTGK
Nearest Stachelhaus code(s):: Trp DSVCVVGTGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)