BGC0000819: paraherquamide biosynthetic gene cluster from Penicillium fellutanum
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Location: 1 - 47,884 nt. (total: 47,884 nt).
This entry is originally from NCBI GenBank JQ708195.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000819
Short description paraherquamide biosynthetic gene cluster from Penicillium fellutanum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Alkaloid (Pyrrole/pyrrolidine)
Loci NCBI GenBank: JQ708195.1
Compounds
  • paraherquamide
Species Penicillium fellutanum [taxonomy]
References
Chemical products information
paraherquamide
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C28H35N3O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGA37268.1
  • phqA
 1 - 1281 (+) prenyltransferase
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  • AGA37269.1
  • phqB
 1606 - 8955 (-) NRPS
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  • AGA37270.1
  • phqC
 9530 - 10696 (+) 2OG-Fe(II)-oxygenase
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  • AGA37271.1
  • phqD
 10913 - 11976 (-) pyrroline-5-carboxylate reductase
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  • AGA37272.1
  • phqE
 12804 - 13601 (+) short chain dehydrogenase
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  • AGA37273.1
  • phqF
 14289 - 16065 (+) efflux pump
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  • AGA37274.1
  • phqG
 17781 - 19064 (+) negative regulator
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  • AGA37275.1
  • phqH
 21682 - 23650 (+) oxidoreductase
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  • AGA37276.1
  • phqI
 25396 - 26784 (-) prenyltransferase
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  • AGA37277.1
  • phqJ
 29106 - 30377 (+) prenyltransferase
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  • AGA37278.1
  • phqK
 31443 - 32934 (-) FAD monooxygenase
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  • AGA37279.1
  • phqL
 34979 - 36840 (-) P450 monooxygenase
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  • AGA37280.1
  • phqM
 37357 - 39638 (-) P450 monooxygenase
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  • AGA37281.1
  • phqN
 43471 - >44349 (-) methyltransferase
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  • AGA37282.1
  • phqO
 46048 - 47884 (+) P450 monooxygenase
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NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Reductive release
NRP-synthases
Gene Modules
phqB
Module 1
Specificity: 4S-methylproline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 2
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Modification domains: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add additional reference
  • Corrected NRP module activity
  • Updated NRP substrate specificities
Detailed domain annotation
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