Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000822.1:
Cluster 1Alkaloid125681

BGC0000822, rebeccamycin biosynthetic gene cluster from Lechevalieria aerocolonigenes. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: rebeccamycin
SMILES string: Copy to clipboard
Molecular formula: C27H21Cl2N3O7
Exact molecular mass: 571.38 Da ([M+H]+)
Molecular activity: Cytotoxic
Molecular target: DNA topoisomerase I

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Indole/benzopyrrole

Gene cluster description

rebeccamycin (BGC0000822). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank AJ414559. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Jose A. Salas (University of Oviedo)

Literature references

1. Sanchez C et al. (2002) The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol 9(4):519-31.