BGC0000825: staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274
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Location: 1 - 22,999 nt. (total: 22,999 nt).
This entry is originally from NCBI GenBank AB088119.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000825
Short description staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Alkaloid
Loci NCBI GenBank: AB088119.1
Compounds
  • staurosporine
Species Streptomyces sp. TP-A0274 [taxonomy]
References
Chemical products information
staurosporine
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C28H26N4O3
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAC55205.1
  • staR
 53 - 2884 (+) transcriptional activator
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  • BAC55206.1
  • staB
 2830 - 3834 (-) dTDP-glucose 4,6-dehydratase
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  • BAC55207.1
  • staA
 3831 - 4883 (-) glucose-1-phosphate thymidyltransferase
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  • BAC55208.1
  • staN
 5410 - 6594 (-) cytochrome P450 StaN
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  • BAC55209.1
  • staG
 6741 - 8081 (-) N-glycosyltransferase
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  • BAC55210.1
  • staO
 8413 - 9927 (+) L-amino acid oxidase
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  • BAC55211.1
  • staD
 9924 - 13214 (+) chromopyrrolic acid synthase StaD
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  • BAC55212.1
  • staP
 13260 - 14513 (+) cytochrome P450
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  • BAC55213.1
  • staMA
 14621 - 15451 (+) methyltransferase
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  • BAC55214.1
  • staJ
 15471 - 16889 (+) 2,3-dehydratase
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  • BAC55215.1
  • staK
 16891 - 17877 (+) 4-ketoreductase
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  • BAC55216.1
  • staI
 17948 - 19057 (+) aminotransferase
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  • BAC55217.1
  • staE
 19113 - 19733 (+) 3,5-epimerase
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  • BAC55218.1
  • staMB
 19860 - 20702 (+) methyltransferase
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  • BAF47693.1
  • staC
 20838 - 22475 (+) monooxygenase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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