BGC0000825: staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274
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Location: 1 - 22,999 nt. (total: 22,999 nt).
This entry is originally from NCBI GenBank AB088119.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000825
Short description staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
AB088119.1
via
Compounds
  • staurosporine
Species Streptomyces sp. TP-A0274 [taxonomy]
References
Chemical products information
staurosporine Evidence:
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C28H26N4O3
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAC55205.1
  • staR
 53 - 2884 (+) transcriptional activator
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    • BAC55206.1
    • staB
    		 2830 - 3834 (-) dTDP-glucose 4,6-dehydratase
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      • BAC55207.1
      • staA
      		 3831 - 4883 (-) glucose-1-phosphate thymidyltransferase
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        • BAC55208.1
        • staN
        		 5410 - 6594 (-) cytochrome P450 StaN
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          • BAC55209.1
          • staG
          		 6741 - 8081 (-) N-glycosyltransferase
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            • BAC55210.1
            • staO
            		 8413 - 9927 (+) L-amino acid oxidase
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              • BAC55211.1
              • staD
              		 9924 - 13214 (+) chromopyrrolic acid synthase StaD
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                • BAC55212.1
                • staP
                		 13260 - 14513 (+) cytochrome P450
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                  • BAC55213.1
                  • staMA
                  		 14621 - 15451 (+) methyltransferase
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                    • BAC55214.1
                    • staJ
                    		 15471 - 16889 (+) 2,3-dehydratase
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                      • BAC55215.1
                      • staK
                      		 16891 - 17877 (+) 4-ketoreductase
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                        • BAC55216.1
                        • staI
                        		 17948 - 19057 (+) aminotransferase
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                          • BAC55217.1
                          • staE
                          		 19113 - 19733 (+) 3,5-epimerase
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                            • BAC55218.1
                            • staMB
                            		 19860 - 20702 (+) methyltransferase
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                              • BAF47693.1
                              • staC
                              		 20838 - 22475 (+) monooxygenase
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                                Biosynthesis information
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Updated bioactivity data
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated compound(s) information (NPAtlas curation)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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