Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000825.1:
Cluster 1Alkaloid122999

BGC0000825, staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: staurosporine
PubChem ID: 44259
SMILES string: Copy to clipboard
Molecular formula: C28H26N4O3
Average molecular mass: 466.541 Da

Class-specific details

Biosynthetic class(es):
Alkaloid

Gene cluster description

staurosporine (BGC0000825). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank AB088119. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

Literature references

1. Onaka H et al. (2002) Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans. J Antibiot (Tokyo) 55(12):1063-71.
2. Onaka H et al. (2003) Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243. Biosci Biotechnol Biochem 67(1):127-38. doi: 10.1271/bbb.67.127.
3. Onaka H et al. (2005) Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274. Biosci Biotechnol Biochem 69(9):1753-9. doi: 10.1271/bbb.69.1753.