LOCUS       BGC0000826             26086 bp    DNA     linear   CON 25-JUL-2016
DEFINITION  Streptomyces clavuligerus ATCC 27064 plasmid pSCL4, whole genome
            shotgun sequence.
ACCESSION   BGC0000826
VERSION     BGC0000826
KEYWORDS    .
SOURCE      Streptomyces clavuligerus
  ORGANISM  Streptomyces clavuligerus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     This record represents the linear plasmid.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:16:33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 26086
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..26086
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000826"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..26086
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1173)
                     /locus_tag="SCLAV_p1107"
     CDS             complement(1..1173)
                     /codon_start=1
                     /locus_tag="SCLAV_p1107"
                     /product="Transcriptional regulator"
                     /protein_id="EFG04593.1"
                     /transl_table=11
                     /translation="MVGHGRTERADAIRGAAVRAAGAATGVDEFFEAVMRAVRPVLRSD
                     VWAGFTVDPDTLLNTGGYYRYAVPLHYMPRMLDIEYREGDVNGVPELSREPVPVRLLSE
                     AVGGARERSPRYRDIIAPLGLSDEARFVLRDRYGTWGGLTLGIGRDTPPFSPEARAVAR
                     SLTEPLGGILRRLHLSRRAWGEHPATPPPPGAAPAPALVLLDEEYTPVQFSPTAPLWLD
                     ELPAPGTPFAPDTGPARGGLSPALYGVAAAVRAPGSPGFLVSWAQTRTRGRVRLHAWHL
                     ALPGPARVAIAVEPAGPGEHIALITAAHGLTPREGEITGLVLRGHSTAEISRLADLSPY
                     TVQEHLKSVFDKTGVRSRRDLVAALFTRHTEPALLKTATADGVTGRTGLL"
     protocluster    1170..24787
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[11169:14787]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11170..14787
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     cand_cluster    1170..24787
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(1324..2973)
                     /gene="staC"
                     /locus_tag="SCLAV_p1108"
     CDS             complement(1324..2973)
                     /codon_start=1
                     /gene="staC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 316; E-value:
                     8.7e-96)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1108"
                     /note="COG:COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases."
                     /product="Staurosporine biosynthesis monooxygenase StaC"
                     /protein_id="EFG04594.1"
                     /transl_table=11
                     /translation="MGSAEWTDVLIVGGGPVGMALALDLAYRGVDCVVADAGDGTVRHP
                     KVSTIGPRSMELFRRWGVADAVRDAGWPPDHPLDIAWVTQVGGHELHRYHRGTAGNRPV
                     FAHTPEPDQVCPAHWLNPVLARAVGVHPDGPLRLRTTVDRVLRRDDYVEATLIDQATGT
                     SGSIRARFLVACDGAASPIRRSCGIDAPPRHRTRVFRNILFRAPGLREQLGDRAALVHF
                     LVRSQTLRFPLRSLDGGDLYTMVVGADEDTPAGRGGGTAAGRGDALALIGDALAVDTPV
                     ELLGDGLWRLTHRVADRYRAGRVFLAGDAAHTLSPSGGFGLNTGIGDAADLGWKLAAAL
                     DGWAGRQLLDTYQTERRPIAVESLEEAHVHLQRTLRRPVPPGIHREGPEGGRARAEMAE
                     QLRNSGVQREFDAPEIHFGLRYRSPAIIEDPTVPVRRGKPDADWRPGSEPGSRAAHAWW
                     DGATSTLDLYGRGFVLLCFAGHEGVAGVERAFAERRVPLTVCRGGAGEVAACYERAFVL
                     VRPDGHVAWRGDALPGDPGRLADTVRGDGADG"
     gene            complement(3075..3950)
                     /gene="staMB"
                     /locus_tag="SCLAV_p1109"
     CDS             complement(3075..3950)
                     /NRPS_PKS="Domain: oMT (35-225). E-value: 6.3e-36. Score:
                     115.3. Matches aSDomain: nrpspksdomains_SCLAV_p1109_oMT.1"
                     /codon_start=1
                     /gene="staMB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 190.4; E-value:
                     6.5e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1109"
                     /note="COG:COG0500 SAM-dependent methyltransferases."
                     /product="Staurosporine biosynthesis methyltransferase
                     StaMB"
                     /protein_id="EFG04595.1"
                     /transl_table=11
                     /translation="MTDTTAPSPPVPEAVGELYDRLTLSAMRDGTFNPNVHIGYWDTPD
                     SDASIEEAMDRFTDVCAERMRVDTLSHVLDLGCGVGGPALRIVSRTGARVTGVSVSEEQ
                     IRTAGRLAAEAGLADRAAFRHGDAMRLPFADASFDAVLALESMCHMPDRHQVLTEVCRV
                     LIPGGRLVLTDVFERAPRKAVRHPGIDRFCRSLMVTMADLDDYAGLIHRSGLRLRALVD
                     VTEGTTLRTGLELARRMAAAPAPAAASEPKGRPAALDEGNFRFPEDGFHPSDLAGVEDF
                     GCLLVTAERP"
     aSDomain        complement(3276..3845)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCLAV_p1109_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="6.30E-36"
                     /label="SCLAV_p1109_oMT.1"
                     /locus_tag="SCLAV_p1109"
                     /protein_end="225"
                     /protein_start="35"
                     /score="115.3"
                     /tool="antismash"
                     /translation="VHIGYWDTPDSDASIEEAMDRFTDVCAERMRVDTLSHVLDLGCGV
                     GGPALRIVSRTGARVTGVSVSEEQIRTAGRLAAEAGLADRAAFRHGDAMRLPFADASFD
                     AVLALESMCHMPDRHQVLTEVCRVLIPGGRLVLTDVFERAPRKAVRHPGIDRFCRSLMV
                     TMADLDDYAGLIHRSGLRLRALVDVTE"
     gene            complement(3947..4648)
                     /gene="staE"
                     /locus_tag="SCLAV_p1110"
     CDS             complement(3947..4648)
                     /EC_number="5.1.3.13"
                     /codon_start=1
                     /gene="staE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1110"
                     /note="COG function: Cell wall/membrane/envelope
                     biogenesis. KEGG: Polyketide sugar unit biosynthesis
                     Streptomycin biosynthesis. COG: COG1898
                     dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes."
                     /product="Staurosporine biosynthesis 3,5-epimerase StaE"
                     /protein_id="EFG04596.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 2.4e-60,
                     bitscore: 193.2, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRARALAVEGALVFTPRVFPDDRGLFLSPFQEAAFTEAHGGPLFP
                     VAQSNHSLSRRGVVRGLHFTVTPPGTAKYVHCARGAALDIVVDIRVGSPTFGRWDAVLM
                     DQRDHRAAYLPVGVGHAFVALEDDTVMSYLLSESYVPENELALSVLDPALGLPVPRGIE
                     PVLSERDRTAVTLAEARRQGLLPEYARCREIERDAASARTAPPPPPHPSQPSQPSHASH
                     AARRRTERPLP"
     gene            complement(4720..5829)
                     /gene="staI"
                     /locus_tag="SCLAV_p1111"
     CDS             complement(4720..5829)
                     /NRPS_PKS="Domain: Aminotran_5 (48-181). E-value: 5.8e-07.
                     Score: 20.6. Matches aSDomain:
                     nrpspksdomains_SCLAV_p1111_Aminotran_5.1"
                     /codon_start=1
                     /gene="staI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     393.6; E-value: 1.5e-119)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1111"
                     /note="COG:COG0399 Predicted pyridoxal phosphate-dependent
                     enzyme apparently involved in regulation of cell wall
                     biogenesis."
                     /product="Staurosporine biosynthesis aminotransferase StaI"
                     /protein_id="EFG04597.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.4e-119,
                     bitscore: 389.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRVWDYLAEYAAERPDLLDAVETVFASGQLVLGASVRGFETEF
                     AAYHGVDHCVGVDNGTNAIRLGLQALGIGPGDEVITVSNTAAPTVVAIDSTGATPVFTD
                     VRADDFLMDTAQVAAAITDRTRCLLPVHLYGQCVDMAPLRRLAERHGLAILEDCAQAHG
                     ARRHGTVAGSTGDAAAFSFYPTKVLGAYGDGGATITSDASVARRLRRLRYYGMEDRYYT
                     LETPAHNSRLDEVQAEILRRRLRRLDRYIDGRRAVARRYADGLADTGLVLPRTAEGNEH
                     VYYVYVVRHPRRDTIIERLRAHDIHLNISYPWPVHTMSGFAHLGYRPGSLPVTEALAAE
                     IFSLPMYPSLSPERQDRVVHAVREVLSTL"
     aSDomain        complement(5287..5685)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCLAV_p1111_Aminotran_5.1"
                     /evalue="5.80E-07"
                     /label="SCLAV_p1111_Aminotran_5.1"
                     /locus_tag="SCLAV_p1111"
                     /protein_end="181"
                     /protein_start="48"
                     /score="20.6"
                     /tool="antismash"
                     /translation="HGVDHCVGVDNGTNAIRLGLQALGIGPGDEVITVSNTAAPTVVAI
                     DSTGATPVFTDVRADDFLMDTAQVAAAITDRTRCLLPVHLYGQCVDMAPLRRLAERHGL
                     AILEDCAQAHGARRHGTVAGSTGDAAAFS"
     gene            complement(5893..6900)
                     /gene="staK"
                     /locus_tag="SCLAV_p1112"
     CDS             complement(5893..6900)
                     /codon_start=1
                     /gene="staK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     197.6; E-value: 5.5e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1112"
                     /note="COG:COG0451 Nucleoside-diphosphate-sugar
                     epimerases."
                     /product="Staurosporine biosynthesis 4-ketoreductase StaK"
                     /protein_id="EFG04598.1"
                     /transl_table=11
                     /translation="MRRDTPGAPGPLITVLGASGFVGSAVVRALARRPVRLRAVARRPC
                     TPPPGPARTTVVRCDLTDRAALADAVAGSDAVVHLLLGDGGWRAAGSEPGAERVNVGVM
                     RDLVEVLRPRPADGAPALVLYGGAASQVGLVPREPLDGSETDRPETPYDRQKLSAEQIL
                     KQATAEGRVRGVSLRLPTVFGEGAAPGAVDRGVVSAMARQALAGRTLTLWNDGTVRRDL
                     LHVDDAAAAFTAALDRPDRLIGRHWLIGSGRGEALGDVFRLVAAAVSVRTGRPPVAVVP
                     MPPPAHAPATDFGSVTIDASAFRAATGWCPRVPLAEGVRRTVAALPRQRWDEDG"
     gene            complement(6902..8560)
                     /gene="staJ"
                     /locus_tag="SCLAV_p1113"
     CDS             complement(6902..8560)
                     /codon_start=1
                     /gene="staJ"
                     /locus_tag="SCLAV_p1113"
                     /note="KEGG: Polyketide sugar unit biosynthesis."
                     /product="Staurosporine biosynthesis 2,3-dehydratase StaJ"
                     /protein_id="EFG04599.1"
                     /transl_table=11
                     /translation="MPSRSGPPAAVPPRAHAPTAPVTVLRPREDRALADRMALSAATGR
                     GARLATRDVRAWLDERRRAGVFQVERVPFAALGEWRSERGTGNLVHRSGRFFTVEGLRV
                     AAEHGAPQGYGPRRGPRREWQQPVIHQPEVGILGILAKEFDGVLHFLMQAKMEPGNAGL
                     LQLSPTVQATRSNYTGAHRGRDVRLIDRFLRPGRAHARLPDHGHGHGRDRVLVDVLHSE
                     QGTWFYRKSNRNMIVETADEIPAADDFRWLTLGQIAVLLHEDDLVNMNARSVLSCVPHP
                     DPAPGALLSDTQLLSWFTGERSRLGVRAQRVPLASVRGWRHGPEAIEREDGRWFRVVAV
                     SVRAGSREVVRWDQPLIEPVGLGLAAFLVHEFDGVPHVLVHARAEGGFLDTVELGPTVQ
                     CVPEECERVPEAERPPFLGTVLSALLGDPPSRVRYQAVHSEEGGRLLNARCRYLLVEAE
                     AGTGTGAGAGAEAGAGTGTAAGAGAGAESEAGAGAGAESEAAPFDPPPGFAWVTPAQLR
                     SLTRHGHYLTVEARTLLACLNAVGAGPRPVLREGV"
     gene            complement(8672..9571)
                     /gene="staMA"
                     /locus_tag="SCLAV_p1114"
     CDS             complement(8672..9571)
                     /NRPS_PKS="Domain: oMT (53-201). E-value: 1.8e-28. Score:
                     90.6. Matches aSDomain: nrpspksdomains_SCLAV_p1114_oMT.1"
                     /codon_start=1
                     /gene="staMA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 174; E-value: 6.3e-53)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1114"
                     /note="COG:COG0500 SAM-dependent methyltransferases."
                     /product="Staurosporine biosynthesis methyltransferase
                     StaMA"
                     /protein_id="EFG04600.1"
                     /sec_met_domain="PCMT (E-value: 3e-07, bitscore: 20.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVPPDDRPAPGKSTKSRRGKTMTAQQNEITPESVGQAYDRFADA
                     GAATVLGGNLHVGHWDEDHPDVPVAEATDRLTDLVAERLALRPGRHLLDVGCGIGVPAL
                     RIAGAHGVRVTGVTVSTQQVAEATRRADRSGVRDQVSFRFADAMSLPFADGSFDDACAI
                     EVLAHLADPAAALAEIRRVVRPGGRLVVSDLCQRQPFTGEGRAVLDEMLSMYEFAGIGS
                     PGEHRAFLAGAGWEVLELTDIGERVRASYGHGAAAFRELARSLEGVAAEGMSRAAEVME
                     AFGRHPDTGYVLITAQRP"
     aSDomain        complement(8969..9412)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCLAV_p1114_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.80E-28"
                     /label="SCLAV_p1114_oMT.1"
                     /locus_tag="SCLAV_p1114"
                     /protein_end="201"
                     /protein_start="53"
                     /score="90.6"
                     /tool="antismash"
                     /translation="NLHVGHWDEDHPDVPVAEATDRLTDLVAERLALRPGRHLLDVGCG
                     IGVPALRIAGAHGVRVTGVTVSTQQVAEATRRADRSGVRDQVSFRFADAMSLPFADGSF
                     DDACAIEVLAHLADPAAALAEIRRVVRPGGRLVVSDLCQRQPFT"
     gene            complement(9597..11042)
                     /gene="staP"
                     /locus_tag="SCLAV_p1115"
     CDS             complement(9597..11042)
                     /codon_start=1
                     /gene="staP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 351.1; E-value:
                     1.3e-106)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1115"
                     /note="COG:COG2124 Cytochrome P450."
                     /product="Staurosporine biosynthesis cytochrome P450 StaP"
                     /protein_id="EFG04601.1"
                     /sec_met_domain="p450 (E-value: 1.4e-15, bitscore: 47.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSPATLPRFDLRGWDSEDIAHPYPVYRRYREAAPVHRGVSGAGE
                     PDTFYVFSYDEVVRVLSSRSLGRDARRTASAEPEPETETETEPVKVKADAEAEAEVEVG
                     ETGRDTGTAAAPVPFPAGCRALRTLVGNWLVFLDPPRHTELRSLLGTEFSPSVVAALRP
                     RITRIADRLLERFVQDIGAPGGADLVAGFAAPFPLLVVCELLGLPQEHHRWLRAHALAL
                     QEAGTTRSRGRESGWSARAEAAAGEFARYFRREIRRRRGETVRRPGTGGPGSGSWAGRR
                     DLLTLLVRAGDRGAPLDTDAIVGTCVHLLTAGHETTTGLLAKAVLALRRHPDLLDELRA
                     APALTPGAVEEFLRHDPPVQAVTRWAYEDIRLGDHEVPRGSRVVALLGSANRDPARFAD
                     PDVLDVRRAPDRQLGFGLGIHYCLGATLARAEAEIGLRALLDGVPGLGRGGHRVDYADD
                     MVFHGPSRLLLRPSASVPPDSAA"
     gene            complement(11170..14787)
                     /gene="staD"
                     /locus_tag="SCLAV_p1116"
     CDS             complement(11170..14787)
                     /codon_start=1
                     /gene="staD"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indsynth"
                     /gene_kind="biosynthetic"
                     /locus_tag="SCLAV_p1116"
                     /product="Staurosporine biosynthesis chromopyrrolic acid
                     synthase StaD"
                     /protein_id="EFG04602.1"
                     /sec_met_domain="indsynth (E-value: 0.0, bitscore: 1636.1,
                     seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFDLPRLHFRGTAVVRLPTGPRSGLVDLATNTALTGDGRAFPA
                     HRPAAEYHDSLDRLDRLDPRDRLGPGPGGAVRPAAAGPHSADTRSPATRSAATRSTTRG
                     EDLSAKGEDFSGKGEDFSGNGHFSVDARIVSAESAAGDFDTADPVVGRRVDLWGHYNEY
                     LATTVNRARVFDVDPASDWTTTLMVGRFCFGRAGRSHDVGYMATGDVHGFHPPRWHHPS
                     AHGRRRSALHQFVVGGGDEGLTWLDETALSPAARRLRDTAAAGEFGGLVVQFALGHPSA
                     PRAPGRPGRWLLRGTIAPWRPDEPRTYPAGRLLVPERPHTAHTAHATAAGRTAGLRPLT
                     VGLTDDHVTLNMITAVPATVRAADGTTAEAALPGPAAEAALPVPVDLGDLELRTADSGR
                     LVARVPRQAYTGAAYALASGVVTVPAELPASAVAEEALCLTGTGSGPYAPGTLLREKEI
                     NVQVDDASLILEHPRGPDDADHDVEVLVRSFVRGRPAAVGGIGVRQFFNPRALPRHPAA
                     RNPKARCADLDIVRLRAGRRDGTGTGSGDGSGNGDGAWSSACVLDTDRTGQGWFTLRGA
                     AAGTARVLLSADAGDLPCDPDQPGSAALGYDHDDALGFWPGAGHLSLRVLPDDWRLSGT
                     TPDEATFDLVHREVLACYEQLYSFMKEEVFSLADRCKVETYAKLIWQMCDPRNKAKTFY
                     MPPTRDLSEPKARLLLTYLRARQSPERLVLTAPAEGGGRAGARARGGGADSRGRLVRLL
                     RDAATLELAVMLQYLYAAYSVPVYGAGREYVRRGLWTPGQLRLACGDGGETLDEGIRGM
                     LLTVAREEMVHFLLVGNILTAVGEPFAVPLVDFGTVNHELPLPLDLALERLGPGSVERF
                     ALIERPDDLVGEVRTSGMTGTEGMEGVKGGDGLPTGGSGPRTGGGGTRTYGGGGGTRTY
                     ANGGGARPYASLSELYADIREGLRSVPDLFPVDRGRGGGEHHLFLRESVDRRHPDYQME
                     VDDLSSALFAIDVITEQGEGGVLAPRGADTSHYASFLRIGELLRGAPGGAGAHPGGARG
                     GPWNPAHPVVRNPTLRRGNGAMVTVTDPDARSVMGLFNRAYFMALQLMAQHFGERPDGS
                     LRRSDLMNAAIDMMTGLMRPLAELLVTLPSGWPGTTAGPSFELDGRPAPVSRPDVARAD
                     IARRLDDLAADCREHPLVPGRVGGMSAFWADHFRPPAHG"
     gene            complement(14879..16921)
                     /gene="staO"
                     /locus_tag="SCLAV_p1117"
     CDS             complement(14879..16921)
                     /EC_number="1.4.3.4"
                     /codon_start=1
                     /gene="staO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1117"
                     /note="COG function: Amino acid transport and metabolism.
                     KEGG: Arginine and proline metabolism Glycine, serine and
                     threonine metabolism Histidine metabolism Metabolic
                     pathways Phenylalanine metabolism Tryptophan metabolism
                     Tyrosine metabolism. COG: COG1231 Monoamine oxidase."
                     /product="Staurosporine biosynthesis L-amino acid oxidase
                     StaO"
                     /protein_id="EFG04603.1"
                     /sec_met_domain="DAO (E-value: 1.4e-10, bitscore: 31.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSPPSGFSCGVLVPGSRAGGPGCSRSAAVHAGAAALLPVRDER
                     AHTAPYCSLAAYSREAVYSRGAVEPFTAVEPPRSAEPVSGPSGQVRPVEPRTQHRPVPA
                     PRSRCGENPARSRRVTAPGHPVRGHGPTLNPSVPAFDGGYGRGAAARTMADKQSPASLF
                     PGPGKAWHRRSPVTVSPREIDGPDGAVAAPKKVTVIGAGIAGLVAAYELERLGHQVQII
                     EGSQEVGGRIHTHHFAGRGRNGPFAELGAMRIPSAHRLTLHYIAELGLQNQVHEFRTLF
                     SDDAAYLATSGGYLRVREAHRTLVAEFAARLPHRNYRDDTLLFGAWLDASIRAIAPRHF
                     CAGLSGDTGVELLDFVDRVDVTPYRCGGAENRIDLHAFFADHPRARSICPPRLERFLDD
                     VLDETSSTIVRLRGGMEALPRRLAARIRGRITTGQEVVGIHVRDESVLLRLRQGTKVTS
                     LDCDYVVCTIPFPVLRRMRLTGFDQEKLDIVRQTAYWGATKLAFHCREPFWEKDGISGG
                     ASFTGGHVRQTYYPPAEGDPALGAVLLASYSIGPDADALSRLSEAERVAVVTRELSVIH
                     PELRRPGMVLGVAGRDWGTHRWSRGAATVRWGQEAVLREAERREAARPQRGLHFAGEHC
                     SSKPAWIEGAIESAIDVAHGIEWYEPRTARRVLATTRPARSNGPV"
     gene            16924..18231
                     /gene="staG"
                     /locus_tag="SCLAV_p1118"
     CDS             16924..18231
                     /codon_start=1
                     /gene="staG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 266.4;
                     E-value: 8.6e-81)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1118"
                     /note="COG:COG1819 Glycosyl transferases, related to
                     UDP-glucuronosyltransferase."
                     /product="Staurosporine biosynthesis N-glycosyltransferase
                     StaG"
                     /protein_id="EFG04604.1"
                     /sec_met_domain="MGT (E-value: 6.5e-56, bitscore: 180.3,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIATTPAPGHVVGVFAVARELVRRGHEVRWYTGEVFRARVERTG
                     ARFEPMRAGLDFGGRSREEAFPEHAGLTGLTSFTTGIRDIFYRTAPGQSHDLLAVLDRF
                     PADCLLADDMCYGACFAAERTGTPLAWVNNSVYILGSRDTPPLGWGLLPNASPLGRVRD
                     ALLRRLTDRIVMRGLRREADRARALVGLDRLRTAALENIARPPDLYLMGTVPSFEFPRA
                     DLLPGTHFVGGLLGPPPDDPFDPPGWWEELRGGDRPVVLITQGTTANDVGRLLVPAVRA
                     LADLDALVVVTTGSTLDVDRLRPLPGNVRLERFVPYHHLLPHVAVMVTNGGYNGVNAAL
                     AQGVPLVVAPGSEENPDVAARVAWTGAGAVLGRRAVSEARLRAAVTAVLHDGRYRRRAR
                     ALAREHRGRDAPRRAAELIESLAGAPGQIPIGGVTR"
     gene            18228..19631
                     /gene="staN"
                     /locus_tag="SCLAV_p1119"
     CDS             18228..19631
                     /codon_start=1
                     /gene="staN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 190.5; E-value: 7.4e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1119"
                     /note="COG function: Secondary metabolites biosynthesis,
                     transport and catabolism. COG: COG2124 Cytochrome P450."
                     /product="Staurosporine biosynthesis Cytochrome P450 StaN"
                     /protein_id="EFG04605.1"
                     /sec_met_domain="p450 (E-value: 7.1e-20, bitscore: 61.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVTGRAAAERFTTGPVTTGPAVTEPAVTEPAVAGRAVAGRTRLA
                     QAPATSMPTDPGPFDCMPELLAAARVAPVVRIPYLDRHAWVVCDPELVRVALTHPALAK
                     DVTLVPAWMRKPGLMLGSQPDPEYARTMIMSDGAHHARIRRLHASVLSPRNTETWGARV
                     GVQVDGFLDELERSRSSGPGEPGGTGGTSTTGDSGEPGEVNVVTAYTHRVPLAFISEML
                     GLPPGAREQLRSITDVILYSSDYPDRARAVGALYGAVEGWVRDPAPLRDGVITGLLSAA
                     TGPDAADGPDAAVTEGEAVVWTLAMIITGYETTGSLISTALYEALRRPCDERPRTDDEI
                     RAWVEETLRVHPPFPHPTWRFATEDIDIGGFLIPRGAPVQVNIAAANRRPDEGADSFTP
                     ERAGQGHLSFGLGPHYCIGASLARLEAQIAVRGFLRRFPRARLSTRTAVAWESEWMIRR
                     MSALPAVLL"
     gene            19690..20856
                     /gene="staA"
                     /locus_tag="SCLAV_p1120"
     CDS             19690..20856
                     /EC_number="2.7.7.24"
                     /codon_start=1
                     /gene="staA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 331.4; E-value:
                     7.9e-101)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1120"
                     /note="COG function: Cell wall/membrane/envelope
                     biogenesis. KEGG: Metabolic pathways Polyketide sugar unit
                     biosynthesis Streptomycin biosynthesis. COG: COG1209
                     dTDP-glucose pyrophosphorylase."
                     /product="Staurosporine biosynthesis glucose-1-phosphate
                     thymidyltransferase StaA"
                     /protein_id="EFG04606.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 4e-15, bitscore:
                     46.7, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPRSEAPRSDASRCDAPRTDAPDTDAPRTDLKALVLAGGSGSRL
                     WPITHTSAKQLVPVAGKPVLFYTLEAIAAAGIRETGVVVGDTAAEIESAVGDGSRFGLD
                     VTYLPQRAPLGLAHAVRIARDYLGDADFLMYLGDNFLVDGVSAAVRRFRTHRPDAQIML
                     TRVADPRAFGVAELDPLGRVTGLEEKPERPRSDLALVGVYLFTPRVHDAVWGLKPSWRG
                     ELEITDAIQQMIDEGRRVDATIVSGYWKDTGNVADLLEVNRLVLDGIESDRPGEVHSSE
                     LIGRVVVEKGATVTGSRIVGPVVVAAGSLVRDSRIGPFTSIDRDCAVVDSEIEDSIVLR
                     GATITGVRRVECSLIGREAEVLSRPRADGGQGAHRLVLGDHSTVRIAS"
     gene            20853..21827
                     /gene="staB"
                     /locus_tag="SCLAV_p1121"
     CDS             20853..21827
                     /EC_number="4.2.1.46"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-217). E-value: 1.8e-15.
                     Score: 48.6. Matches aSDomain:
                     nrpspksdomains_SCLAV_p1121_NAD_binding_4.1"
                     /codon_start=1
                     /gene="staB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     315.3; E-value: 7.8e-96)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SCLAV_p1121"
                     /note="COG function: Cell wall/membrane/envelope
                     biogenesis. KEGG: Polyketide sugar unit biosynthesis
                     Streptomycin biosynthesis. COG: COG1088 dTDP-D-glucose
                     4,6-dehydratase."
                     /product="Staurosporine biosynthesis dTDP-glucose
                     4,6-dehydratase StaB"
                     /protein_id="EFG04607.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.1e-28, bitscore:
                     88.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.2e-17,
                     bitscore: 52.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 5.5e-16, bitscore:
                     48.6, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGVGFIGSHFVRGRVHEDTVTVLDRLTYAGNPANLEPVA
                     GRFTFVHGDICDAALLKEVVPGHDLVVNFAAESHVDRSIAGAGEFVRTNVLGVQTLLQA
                     CLDAGIPRVVQVSTDEVYGSIDTGSWDETAPLSPNSPYAASKAAGDLIALAYARTHRLP
                     VSITRCGNNYGPYQYPEKLVPLFVTHLLDGRNVPLYGDGGHVRDWIHVDDHCRAIRLVA
                     ERGAPGEVYHVAGTAELTNIELTLRLLDALHAPGQRVEPVPDRKAHDRRYSLTDAKLRA
                     LGYAPRIAFERGLAETVAWYAAHRPWWEPLKEHVPLARTGLTP"
     aSDomain        20865..21503
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCLAV_p1121_NAD_binding_4.1"
                     /evalue="1.80E-15"
                     /label="SCLAV_p1121_NAD_binding_4.1"
                     /locus_tag="SCLAV_p1121"
                     /protein_end="217"
                     /protein_start="4"
                     /score="48.6"
                     /tool="antismash"
                     /translation="VTGGVGFIGSHFVRGRVHEDTVTVLDRLTYAGNPANLEPVAGRFT
                     FVHGDICDAALLKEVVPGHDLVVNFAAESHVDRSIAGAGEFVRTNVLGVQTLLQACLDA
                     GIPRVVQVSTDEVYGSIDTGSWDETAPLSPNSPYAASKAAGDLIALAYARTHRLPVSIT
                     RCGNNYGPYQYPEKLVPLFVTHLLDGRNVPLYGDGGHVRDWIHVDDHCRA"
     gene            complement(21817..25095)
                     /gene="staR"
                     /locus_tag="SCLAV_p1122"
     CDS             complement(21817..25095)
                     /codon_start=1
                     /gene="staR"
                     /gene_functions="regulatory (smcogs) SMCOG1149:LuxR family
                     transcriptional regulator (Score: 169.9; E-value: 1.4e-51)"
                     /gene_kind="regulatory"
                     /locus_tag="SCLAV_p1122"
                     /note="COG:COG2771 DNA-binding HTH domain-containing
                     proteins."
                     /product="Staurosporine biosynthesis transcriptional
                     activator StaR"
                     /protein_id="EFG04608.1"
                     /transl_table=11
                     /translation="MAGSRTRSTRSFPVVPVAASAPSGQRTRTRTVRHACTETRAMYSF
                     LPVVVIVIGSAWMPNARTLPQMHGRERQLAQICAHLRAVANSRRGVVLLVEAAPGAGKT
                     RLLGEAVGAAERNSFAVVGSRGGGAGGDAGSGPGRGAGSGPGGGAGADTGDGGAPDGSG
                     SGAAPGAVRAPAGARAVIEAARARLARDAEPTRTLVVFDDLHRAGPSALTALSDLIVTF
                     RTRPVVWLLAFTSDRPPARGPAWDPAGDPDGGAMRDTAPYDPVRACVGGLRDRILVEAV
                     RELGPLSGDALTRLVTDCTGAVPDPALLALAECVGGTPRAVIELMRGLVEDGDVHVVDG
                     LSRIVHGTAPGRIPAGGGVRLPAPVPKRFSAWVRRDLRSLSESTLRALRLAAVLGSPFA
                     PEDLSTLLGQAPAGLLTAVDEAVVQGLLVCGEHDLAFRSEPIWRVLLDSVPPPVCVLLR
                     RQAAEMLLSRPGGVERAALQLVHVAHHGNAEELRVIAEGARKLLATDPPTAARLAIRCM
                     ELLSPGQPERVRLARTAVEAYTRAGELDRAITLARETIDEATGLAAPVSAEDARTTRGT
                     GTTGTVRGTENARSAGGTRAVGGARVVGTAETTGAAEDIAALQASMSTALLLLGNAPMA
                     RRAADDALAAQQGGRPRREAVITHLAASYLTGDSTAPERAQKIISAPDPHAQAVQVAMI
                     FHAFGQWRDGKVGSAVETLREAVALDPGGDDARLLDPRWFLAFALTRTDEYEEAAAVVR
                     RSTRSGGAAGSSAATGARTPAAAVAALLRAPLHLALGRLDDAEEAARTGVGADGGPHVP
                     LLAPQAWLVLAHAALRRGALARAEDHLRTLDQGFPQHASSPWSAARDLLSAQLAEARTD
                     ARAAADVLAEIGERPGGLRELVLVDPAAAAWCVRCALAADLPGLVKTVVDTVDQLQAHN
                     PCVPAVLASAAHARALAGKDAEGVDRAGLLHRNPWARASVAEDHAGLLLDRGEHERAIG
                     ELDRAMNAYGALGGEWDAARVRARLRELGVRRRHWTHTKRPVSGWESLTTTERKVAELV
                     AGGLTNRQAARHLYISPHTVGFHLRQIYRKLGIQSRTALIRFTA"
     gene            complement(25199..26086)
                     /locus_tag="SCLAV_p1123"
     CDS             complement(25199..26086)
                     /codon_start=1
                     /locus_tag="SCLAV_p1123"
                     /note="COG:COG0500 SAM-dependent methyltransferases."
                     /product="Putative methyltransferase"
                     /protein_id="EFG04609.1"
                     /transl_table=11
                     /translation="MRRCASERQGEPPTGNPGAGTGRSARGWDHGLPFRQQFLVFHGGG
                     VMLAVAAPVVRPAGPSPSPLLRRGVLMSTTPATSADHDAAAHSADPTVFWEERYQVSDR
                     IWSGRPNPLLVREVEGLEPGTALDLGCGEGADAVWLAARGWRVTGVDISATALRRAALH
                     AEEAGEAGVAERLSWERHELGKTFPEGRYDLVNAQFLQSPVALDQDRVLSLAAEAVAPG
                     GTLLVVMHGAWPSWQHEHPFHAEFPTLDGLLERLALPEGWRVETLEAVERPCSSPEGVP
                     GTRVDNVWRFSRAV"
ORIGIN
        1 tcagagaaga cccgtacgac ctgtgactcc gtccgccgtc gccgtcttca gcagggccgg
       61 ttccgtgtgg cgggtgaaga gcgccgccac caggtcgcgg cggctgcgga cgccggtctt
      121 gtcgaagacc gacttcagat gttcctggac ggtgtacggg gagagatccg ccaaccggga
      181 gatctcggcc gtggagtggc cgcgcaggac cagaccggtg atctcgccct cgcggggggt
      241 gagcccatgg gcggcggtga tcagggcgat gtgttcgccc gggccggccg gttccaccgc
      301 tatcgcgacc cgggcggggc cggggagcgc gaggtgccag gcgtggaggc ggacccggcc
      361 gcgggtgcgg gtctgggccc aggagaccag gaaacccggg gagccggggg cgcggacggc
      421 cgccgcgact ccgtacagcg cgggggagag accgccgcgc gcggggccgg tgtccggtgc
      481 gaagggggtt ccgggagcgg gcagttcgtc cagccagagc ggggccgtgg ggctgaactg
      541 caccggcgtg tactcctcgt ccaggagcac cagcgccggg gccggggcgg cgccgggggg
      601 cgggggcgtg gccgggtgct cgccccaggc gcgccgggac agatggagcc ggcgcaggat
      661 tccccccagc ggttcggtga gcgaccgcgc caccgctcgc gcctccgggc tgaacggcgg
      721 tgtgtcgcgt ccgatgccga gggtgaggcc gccccaggtg ccgtaccggt cgcgcagcac
      781 gaaacgggcc tcgtcggaga ggcccagcgg agcgatgatg tcccggtacc gggggctgcg
      841 ctcccgggcc ccgccgaccg cctcgctgag cagacgcacc ggcacgggtt cccgggacag
      901 ttcgggcacc ccgttgacgt cgccctcgcg gtactcgatg tccagcatgc ggggcatgta
      961 gtggagcggg acggcgtaac ggtagtagcc gccggtgttc agcagggtgt ccgggtcgac
     1021 ggtgaacccg gcccagacat cggacctgag caccgggcgc acggcccgca tcaccgcctc
     1081 gaagaactcg tccaccccgg tcgccgcgcc cgccgcgcgc actgccgcgc cccggatcgc
     1141 gtcagcacgt tccgttctcc cgtggcccac catggccgaa aggctagacc tgggggcatg
     1201 ccaccacggc atggttcgac ggcgcgtcga acacccgctc gcagccgtcg gttctcagcc
     1261 gcccgccctc agccccgtcg ccgccggccc tcagccttgt cgcccgccgc cggccgtcgg
     1321 ttctcagccg tcggccccgt cgccccgtac cgtgtcggcg agcctccccg ggtcccccgg
     1381 aagcgcgtcg ccgcgccacg ccacatggcc gtccggccgc accagcacga aggcccgttc
     1441 gtagcacgcg gccacctccc cggcgccgcc acggcacacc gtcagcggaa cgcgccgttc
     1501 ggcgaaggcg cgctcgaccc ccgccacccc ctcgtgcccg gcgaagcaca gcagcacgaa
     1561 cccgcgcccg tacagatcga gcgtggacgt ggccccgtcc caccacgcgt gcgcggcgcg
     1621 gctgccgggc tcgctgccgg ggcgccagtc ggcgtccggc tttccgcggc gcacggggac
     1681 ggtggggtcc tcgatgatcg cgggggagcg gtagcgcagc ccgaagtgga tctccggggc
     1741 gtcgaactcc cgctggacgc cgctgttccg gagctgttcc gccatctccg cgcgcgcccg
     1801 cccgccctcg ggcccctcgc ggtggatgcc gggcggcacc ggccgccgca gggtgcgctg
     1861 caagtggaca tgcgcctcct ccagactctc cacggcgatc ggtctgcgtt cggtctgata
     1921 ggtgtcgagc aactgcctcc cggcccagcc gtccagtgcg gcggcgagct tccagcccag
     1981 gtcggcggcg tcgccgatac cggtgttgag cccgaaaccg ccggacggcg acagcgtgtg
     2041 cgcggcgtcc ccggcgagga agacccgtcc ggcccggtac cggtcggcga cccggtgggt
     2101 gagccgccac aggccgtcgc ccagcaactc caccggtgtg tcgacggcga gcgcgtcgcc
     2161 gatcagcgcc agcgcgtcac cccgccccgc ggcggtgccg ccgccccgcc cggccggagt
     2221 gtcctcgtcc gcgcccacga ccatggtgta cagatcgccg ccgtccagcg aacgcaacgg
     2281 gaagcgcagg gtctgcgacc gtacgaggaa gtggacgagg gcggcgcggt cgccgagctg
     2341 ttccctgagg ccgggggcgc ggaagaggat gttacggaag acccgggtgc ggtgccgggg
     2401 cggcgcgtcg atgccgcagc tccggcggat cggggaggcg gcgccgtcgc aggcgaccag
     2461 gaagcgcgcg cgtatgctgc cgctcgtccc ggtggcctga tctataaggg tcgcctccac
     2521 gtaatcgtct ctccgcagca cacggtcgac ggtcgtacgc agtcgcagcg gcccgtccgg
     2581 atggaccccc accgcccggg ccagcaccgg attcagccag tgcgccgggc agacctggtc
     2641 gggctccggc gtatgggcga agaccgggcg gttcccggcc gtcccccggt ggtagcggtg
     2701 cagctcatgg ccgcccacct gggtcaccca cgcgatgtcc agggggtggt ccgggggcca
     2761 tccggcgtcc cgtacggcgt ccgcgacacc ccagcggcgg aacagctcca tcgaacgcgg
     2821 gccgatcgtg ctcaccttgg ggtgccggac cgttccgtca ccggcgtccg cgaccacgca
     2881 gtccaccccc cggtacgcca gatccagcgc cagcgccatc ccgaccgggc caccgcccac
     2941 gatcaggaca tcggtccact cggcggagcc catcgtcccg tcccctctcc cgtcccttcg
     3001 tccgtcctct cgtccggccc ttcccccggt acgtccgctt ccggcccctc tcccggcacg
     3061 tccaccgccg ccgctcacgg gcgttccgcg gtcaccagca gacagccgaa gtcctcgaca
     3121 cccgccaggt cggacgggtg gaaaccgtcc tcggggaagc ggaaattgcc ctcgtcgagc
     3181 gccgcgggcc gccccttcgg ctccgatgcc gcggccgggg ccggagctgc tgccatccgc
     3241 cgcgccagtt cgagaccggt gcgcagcgtc gtcccctcgg tgacgtcgac gagggcgcgc
     3301 agccgcagcc cgctgcggtg gatcagcccg gcgtagtcgt cgaggtccgc catcgtcacc
     3361 atgaggctgc ggcagaagcg gtcgatgccc gggtgccgca ccgccttgcg cggggcgcgt
     3421 tcgaacacat cggtcagcac cagccgtccg ccggggatca gcacccggca cacctcggtg
     3481 agcacctggt gccggtccgg catgtggcac atcgactcca gggccagcac ggcgtcgaac
     3541 gacgcgtccg cgaacggcag ccgcatcgcg tcgccgtgcc ggaaggcggc ccggtcggcg
     3601 agcccggcct cggccgccag tcggcccgcc gtcctgatct gctcctcgct gacactgacg
     3661 ccggtgaccc gggcacccgt acgggacacg atccgcagcg cggggccgcc caccccgcag
     3721 cccaggtcga gcacatggga cagcgtgtcc acccgcatcc gctcggcgca cacatccgtg
     3781 aaccggtcca tcgcctcctc gatggaggcg tcggagtccg gtgtgtccca gtagccgata
     3841 tggacattgg ggttgaaggt gccgtcccgc atcgcgctca gcgtcagccg gtcgtacagc
     3901 tcgccgacgg cttccggtac gggtgggctc ggggcggtcg tgtcggtcat ggcagcggcc
     3961 tttcggttcg acggcgggcg gcatgagatg cgtgagaggg ctgagagggc tgggaagggt
     4021 gagggggcgg tggcggcgcg gtgcgggcgg acgcggcgtc ccgttcgatc tcccggcacc
     4081 gcgcgtactc cggcagcagc ccttggcgcc gtgcctcggc gagcgtgacc gccgtgcggt
     4141 cccgttcgga gaggaccggt tcgatgcccc gcggaacggg cagcccgagg gcgggatcga
     4201 ggacggacag ggcgagttcg ttctccggca catagctctc ggagagcaga tacgacatga
     4261 cggtgtcgtc ctccagcgcc acgaacgcgt ggcccacccc gacggggagg taggcggccc
     4321 ggtggtcccg ctggtccatc aggaccgcgt cccaccggcc gaacgtgggc gacccgaccc
     4381 tgatgtcgac gacgatgtcc agggccgccc cccgcgcgca gtggacgtac ttcgcggtgc
     4441 cgggcggcgt cacggtgaag tggaggcctc gcaccacacc gcgccgggac agactgtggt
     4501 tgctctgcgc gacggggaac agcgggccgc cgtgggcctc ggtgaacgcc gcctcctgga
     4561 acggcgagag gaacagcccc cggtcgtcgg ggaagacccg gggcgtgaag acgagggccc
     4621 cctcgacagc gagcgcgcgt gcgcgcatgt tcgttctcct cccatggccc gttcggctcg
     4681 ttctgcggat gacggatgac ggatgacgga cggcggatgt cacagcgtcg acagcacctc
     4741 gcgcacggcg tggacgaccc ggtcctgtcg ttcgggggag agcgagggat acatcggcaa
     4801 cgagaagatc tcggcggcca gcgcctcggt caccgggagc gagccggggc ggtaaccgag
     4861 atgggcgaac ccgctcatgg tgtgcacggg ccacggatag ctgatgttca gatggatgtc
     4921 gtgggcccgc agccgctcga tgatcgtgtc ccgccggggg tggcgcacca catacacgta
     4981 gtacacgtgc tcattgccct cggcggtgcg cggcagcacc agaccggtgt cggcgagccc
     5041 gtcggcgtag cggcgcgcga cggcccgccg cccatcgatg taccggtcga gccgccgcag
     5101 cctgcgccgc aggatctcgg cctggacctc gtccagacgg ctgttgtgcg cgggcgtctc
     5161 aagcgtgtag tagcggtcct ccatgccgta gtaccgcagc cgccgcagcc gccgtgccac
     5221 ggacgcgtcc gaggtgatcg tcgcgccgcc gtcgccgtac gccccgagga ccttcgtcgg
     5281 gtagaaggag aacgcggcgg cgtcgccggt cgagcccgcg accgtgccgt gccgccgggc
     5341 cccgtgcgcc tgggcgcagt cctccaggat cgccagcccg tgccgctccg cgagccgccg
     5401 cagcggggcc atgtccacgc actgcccgta cagatgcacc gggaggagac agcgggtgcg
     5461 gtcggtgatc gccgccgcca cctgcgcggt gtccatgagg aagtcgtccg cgcggacgtc
     5521 ggtgaagacg ggtgtggccc ccgtggagtc gatggcgacc accgtcggcg ccgccgtgtt
     5581 cgacaccgtg atcacctcgt cgcccggccc gatgcccagc gcctggagcc ccagcctgat
     5641 ggcgttggtc ccgttgtcga cccctacgca gtggtcgacc ccgtgatacg cggcgaactc
     5701 ggtctcaaac ccgcgcacac tcgcgccgag tacgagctgc cccgaggcga agaccgtctc
     5761 cacggcgtcc aggaggtccg gacgctcggc cgcgtactcc gccaggtagt cccatacacg
     5821 tatcgacacc gtcggccttt ccgaagggtt ccagaagatt ccggagggtt ccgggaccta
     5881 tgagggtgct ggtcatccgt cctcgtccca ccgctgccgc ggcagggcgg cgaccgtacg
     5941 gcgcacccct tcggcgagcg ggacccgggg gcaccagccg gtggccgccc ggaacgcgga
     6001 cgcgtcgatc gtcacgctcc cgaagtccgt ggcgggcgcg tgcgcgggcg ggggcatcgg
     6061 caccacggcg accgggggcc gccccgtacg gacggagacg gcggcggcga cgagccggaa
     6121 gacgtcgccg agcgcctcgc cccgcccgga gccgatcagc cagtggcggc cgatcaggcg
     6181 gtccgggcgg tcgagcgccg ccgtgaacgc cgccgcggca tcgtcgacat ggagcagatc
     6241 gcgccgcacc gtcccgtcgt tccacagggt gagcgtccgg cccgcgagcg cctgccgcgc
     6301 catcgcggag accacccccc ggtcgacggc gcccggcgcc gcgccctcgc cgaacaccgt
     6361 gggcagccgc agactgacgc cgcgcacccg gccctcggcc gtggcctgtt tgaggatctg
     6421 ctcggcgctc agcttctgcc ggtcgtaggg ggtctcgggg cggtcggtct cgctgccgtc
     6481 gagaggttcc cgcggcacca ggccgacctg cgaggcggcg cccccgtaca gcacgagcgc
     6541 aggagcgccg tccgcggggc gcggacgcag gacctcgaca aggtcccgca tcacacccac
     6601 gttcacgcgc tcggcgcccg gttcgctccc cgccgcccgc cagccgccgt cccccagcag
     6661 cagatgcacc accgcgtccg agcccgcgac cgcgtcggcg agcgccgccc ggtcggtgag
     6721 atcgcagcgg acgacggtcg tccgggccgg tccgggcggg ggtgtgcacg ggcggcgcgc
     6781 cacggcccgc agccggaccg ggcggcgcgc cagcgcgcgg acgacggccg agccgacgaa
     6841 ccccgaggcg ccgagcacgg tgatcagcgg tccgggtgcc cccggtgtgt cgcgccgcat
     6901 gtcacacacc ctcccggaga acggggcggg gtcccgcccc gacggcgttg aggcaggcca
     6961 gcagggtgcg ggcctccacg gtgaggtagt gcccgtgccg ggtgagggac ctgagctggg
     7021 cgggtgtgac ccaggcgaag ccgggcggcg ggtcgaacgg ggccgcctcc gactccgccc
     7081 ccgcgcctgc cccggcctcc gactccgccc ccgcgcctgc cccggccgct gtgcccgtgc
     7141 ctgccccggc ctccgccccc gcgcccgcgc ctgtgcccgt gcccgcttcc gcttcgacga
     7201 ggagatagcg gcagcgggcg ttcaggagcc ggccgccctc ctcggagtgg acggcctgat
     7261 agcggacgcg cgacggcgga tcgcccagga gcgcgctgag gacggtcccc aggaacggcg
     7321 gacgttccgc ttccggtacc cgttcgcact cctcgggaac acactggacg gtcggcccca
     7381 gctcgaccgt gtccagaaaa ccgccctccg cccgcgcgtg caccaggaca tgcggcaccc
     7441 cgtcgaactc gtggacgagg aaggccgcga gtccgaggcc gacgggctcg atcagcggct
     7501 ggtcccagcg gaccacctcc cggctcccgg cccgcacgga gacggcgacg acccggaacc
     7561 agcggccgtc ctcgcgctcg atcgcctccg ggccgtgccg ccagccgcgc acggaggcga
     7621 gcggcacgcg ctgggcacgc acgcccaggc gcgagcgctc cccggtgaac cacgacagga
     7681 gctgggtgtc ggagagcagc gcgccgggcg ccgggtccgg gtggggcaca caggacagca
     7741 cgctccgggc gttcatgttg accaggtcgt cctcgtgcag cagcacggcg atctgaccga
     7801 gggtcagcca gcggaagtcg tccgccgccg ggatctcgtc ggcggtctcg acgatcatgt
     7861 tgcggttgga cttccggtag aaccacgtcc cctgctcgga gtggaggaca tcgacaagga
     7921 cccggtcgcg gccgtgtccg tgtccgtggt cggggaggcg ggcgtgggcg cggccgggcc
     7981 gcagaaagcg gtcgatcagc cggacgtccc ggccccggtg ggccccggtg tagttgctcc
     8041 gggtggcctg cacggtcggg gagagctgga gcagacccgc gttccccggc tccatcttcg
     8101 cctgcatcag gaagtgcagc acgccgtcga actccttggc cagaatgccc aggatgccga
     8161 cctcgggctg gtggatgacg ggctgctgcc actcccggcg ggggccgcgg cggggcccgt
     8221 acccctgggg ggcgccgtgc tccgccgcca cccgcagacc ctcgacggtg aagaaccgcc
     8281 cactgcggtg cacgaggttc ccggtgccgc gctcggaccg ccactcgccc agcgcggcga
     8341 acgggacgcg ctccacctgg aacacccccg cccggcggcg ctcgtccagc caggcgcgga
     8401 cgtcccgcgt cgcgagccgc gccccacggc cggtcgccgc cgacagggcc atccggtcgg
     8461 ccagtgcgcg gtcctcgcgc gggcgcagca cggtgacggg ggcggtgggg gcgtgcgcgc
     8521 gcgggggaac ggcggcgggc gggccggacc gggacggcat cgggaactcc ctgtctgcgg
     8581 agagagaaag gaaggaacgg gagaacggag gagccgggga gcggagggaa cgggggcggc
     8641 ggggggagcg ggggcggcgg gcgcccggtc gtcagggccg ctgcgcggtg atcaggacat
     8701 agccggtgtc cgggtgcctc ccgaacgcct ccatcacctc ggccgccctg gacatcccct
     8761 ccgccgcgac accctccagc gagcgggcca gctcccggaa ggccgccgcg ccgtgcccgt
     8821 aactggcccg gacccgctcc ccgatgtccg tcagctccag cacctcccag cccgccccgg
     8881 ccaggaacgc gcggtgctcc ccgggcgagc cgatcccggc gaactcgtac atgctcagca
     8941 tctcgtccag cacggcccgg ccctcgccgg tgaacggctg ccgctggcac aggtcggaga
     9001 cgaccagccg gccgccgggg cggacgaccc ggcggatctc cgcgagcgcg gcggcggggt
     9061 cggccagatg cgccaggacc tcgatcgcgc aggcgtcgtc gaaggaaccg tccgcgaagg
     9121 ggagggacat ggcgtccgcg aaccggaacg agacctgatc gcggaccccg gagcggtccg
     9181 cccgccgtgt cgcctccgcg acctgctggg tgctgacggt gacgccggtc acccggaccc
     9241 cgtgcgcccc cgcgatccgc agcgccggga cgccgatgcc gcagcccacg tccagcagat
     9301 gccgccccgg ccggagggcg agacgttcgg cgacgaggtc ggtgaggcgg tcggtggcct
     9361 cggcgaccgg gacatcgggg tggtcctcgt cccagtggcc cacatggagg ttgccgccca
     9421 ggacggtcgc ggcgcccgcg tcggcgaacc ggtcgtacgc ctggccgacg gactcggggg
     9481 tgatctcgtt ctgctgtgcc gtcatcgtct tccctctcct gctcttcgtg ctcttcccgg
     9541 gtgccgggcg gtcgtccggg ggtaccgcca tggggtggtg ctgtcacgcg gtgctgtcac
     9601 gcggcgctgt cagggggcac ggaggcggac gggcggagca gcagtcggct cggcccgtga
     9661 aaaaccatgt cgtcggcgta atccacccgg tggccgccgc gcccgagacc gggaacgccg
     9721 tccagcagcg cccgcagacc gatctcggcc tcggcgcggg ccagggtcgc gccgaggcag
     9781 tagtggatac ccagaccgaa gccgagctgc cggtcgggcg cacggcgcac atccaggaca
     9841 tcggggtcgg cgaagcgcgc ggggtcccgg ttcgccgagc ccagcagggc gacgacacgg
     9901 ctgccgcgcg gtacctcgtg gtcaccgagg cggatgtcct cgtacgccca gcgcgtcacc
     9961 gcctgcaccg gcgggtcgtg gcgcaggaac tcctccacgg cccccggtgt cagcgcggga
    10021 gccgcacgca gctcgtcgag gaggtccggg tgcctccgca gcgccagcac cgccttggcc
    10081 aggagcccgg tggtggtctc gtgcccggcg gtgagcagat ggacgcacgt gcccacgatc
    10141 gcgtccgtgt ccagcggtgc gccgcggtcc ccggcccgga ccaggagggt gagcagatca
    10201 cggcgcccgg cccaggagcc gctgccgggg ccgccggtac cgggccgccg taccgtctcc
    10261 ccgcgccgcc gccgtatctc ccgccggaag tagcgggcga actccccggc ggctgcctcg
    10321 gcccgcgcgg accagccgct ctcccggccc cgggaccggg tggtgcccgc ctcctggagc
    10381 gccagcgcgt gggcgcggag ccagcggtgg tgctcctgcg gaagccccag cagttcacag
    10441 acgacgagga gggggaaggg ggccgcgaag cccgcgacga ggtccgcgcc gccgggcgcc
    10501 ccgatgtcct ggacgaatcg ttccagcagg cggtcggcga tccgtgtgat acggggccgg
    10561 agcgccgcga cgaccgaggg cgagaactcc gtaccgagca gggagcgcag ctcggtgtgg
    10621 cgcggcgggt cgaggaagac cagccagttc ccgacgagcg tccgcagggc ccggcacccg
    10681 gcgggaaacg gaacgggcgc cgcggcggtg cccgtgtccc tgcccgtctc ccccacctcc
    10741 acctccgcct ccgcctccgc gtccgccttg accttcaccg gctccgtctc cgtctccgtc
    10801 tccggctccg gctcagcgga cgcggtgcgc cgcgcgtccc ggccgaggct ccggctcgac
    10861 agcacccgga cgacctcgtc gtacgagaag acatagaagg tgtccggctc gcccgccccc
    10921 gacacccccc ggtggaccgg cgcggcctcc cggtagcgcc ggtacacggg gtacgggtgg
    10981 gcgatgtcct cgctgtccca gcctctgagg tcgaacctcg gcagcgtcgc gggtgatggc
    11041 atgcggtctc cgtcggtcgt cggtcgggtg cggtcgtggg ccgtgggtcg ggtgcggtcg
    11101 tcggtcgggg tgtgctcgtc ggtcgaggcg cggttgctcg gtcgggtgcg gtcggttcgt
    11161 cgtcgggcgt cagccgtggg cgggcggtcg gaagtggtcc gcccagaacg cgctcatccc
    11221 gcccacccgg cccggcacca gcgggtgctc gcggcagtcc gcggcgaggt cgtcgaggcg
    11281 gcgggcgatg tcggccctcg ccacgtccgg ccgggacacg ggcgcgggcc gcccgtccag
    11341 ctcgaacgac ggcccggcgg tcgtgcccgg ccaccccgag ggcagtgtca ccagcagttc
    11401 ggccagcggg cgcatcagcc ccgtcatcat gtcgatcgcc gcgttcatca gatcggagcg
    11461 gcgcagactc ccgtccgggc gctccccgaa gtgctgcgcc atgagctgga gcgccatgaa
    11521 gtaggcacgg ttgaacagcc ccatgaccga ccgggcgtcg gggtcggtga ccgtcaccat
    11581 ggccccgttc ccccggcgca gggtcgggtt ccgtacgacg ggatgggccg ggttccacgg
    11641 gccgccccgc gcgccgcccg ggtgcgcccc cgccccgccg ggcgcgccgc gcagcagctc
    11701 gccgatccgc aggaacgagg cgtagtgcga ggtgtcggcc ccgcgcgggg cgagcacccc
    11761 gccctccccc tgctcggtga tgacgtcgat cgcgaacagc gcgctggaga ggtcgtcgac
    11821 ctccatctgg tagtcggggt ggcgccggtc gacggactcc cgcagaaaga gatggtgctc
    11881 cccgcctccc ctgccccggt ccacggggaa caggtccggg acggatcgca gcccctcccg
    11941 gatgtccgcg tacagctcgc tcagcgaggc gtagggccgc gcgccgcccc cgttcgcgta
    12001 cgttcgcgtg ccgcccccgc ccccgtacgt tcgcgtgccg cccccgcccg tccgaggccc
    12061 gctcccgccc gtcggcaggc cgtcgccccc cttcacccct tccatcccct ccgtgccggt
    12121 catcccgctc gtccgcacct cgccgacgag gtcgtcgggc cgttcgatca gcgcgaaccg
    12181 ctcgacgctg ccgggcccca gccgttccag ggcgagatcc agcggcaggg gcagctcgtg
    12241 gttgacggtg ccgaagtcga ccagggggac ggcgaagggc tcgccgacgg ccgtgaggat
    12301 gttgccgacg agcaggaagt ggaccatctc ctcgcgggcg acggtcagca gcatgccgcg
    12361 gatgccctcg tccagggtct cgccgccgtc cccgcaggcg agccggagct gcccgggtgt
    12421 ccacagaccc cggcgtacgt actcccgccc ggcgccgtat acggggaccg agtaggccgc
    12481 gtacagatac tggagcatga cggccagctc cagcgtggcg gcgtcgcgca gcagccggac
    12541 gaggcggccc cgtgagtcgg cacccccgcc cctggccctg gccccggcgc gcccgccgcc
    12601 ttccgccggg gccgtcagaa ccaaccgttc cggcgactgc cgggcccgta gataggtcag
    12661 cagcagacgc gccttcggct cggacagatc ccgggtcggc ggcatgtaga aggtcttcgc
    12721 cttgttgcgc gggtcgcaca tctgccagat cagcttcgcg tacgtctcca ccttgcaccg
    12781 gtccgcgagg ctgaagacct cctccttcat gaacgagtac agctgctcgt agcacgcgag
    12841 gacctcccgg tggacgaggt cgaaggtcgc ctcgtcgggg gtggtcccgg acagccgcca
    12901 gtcgtcgggg agcacccgca gcgacagatg acctgcgccg ggccagaagc cgagcgcgtc
    12961 gtcgtggtcg tagccgaggg ccgccgagcc gggctggtcc gggtcgcagg gcagatcacc
    13021 ggcgtcggcg gagagcagga cgcgggcggt accggccgcc gcgccccgca gggtgaacca
    13081 gccctggccg gtgcggtccg tgtccaggac acaggcgctc gaccaggccc cgtccccgtt
    13141 cccgctcccg tccccgctcc cggttccggt gccgtcccgc cgtcccgcgc gcagccggac
    13201 gatgtcgagg tccgcgcacc gcgccttggg gttccgcgcg gccggatggc gcggcagggc
    13261 cctggggttg aagaactgcc gtacgccgat cccgccgacg gccgccggac ggccccggac
    13321 gaaggaccgc accagcacct cgacatcgtg gtccgcgtcg tccgggcccc ggggatgctc
    13381 caggatcagc gacgcgtcgt cgacctggac gttgatctcc ttctcgcgca gcagtgtccc
    13441 gggggcgtat gggccgctcc cggtgcccgt cagacacagc gcctcctcgg ccacggcgct
    13501 cgccgggagt tcggcgggga ccgtcaccac cccgctggcc agggcgtacg ccgccccggt
    13561 atacgcctgc cgggggacgc gggccaccag ccgtccgctg tccgccgtcc gcagttcgag
    13621 atcgccgagg tcgaccggca ccgggagggc ggcctctgcc gccggtcccg ggagggcggc
    13681 ctctgccgtg gtgccgtccg ccgcccggac ggtggcgggc accgcggtga tcatgttgag
    13741 ggtgacgtgg tcgtccgtga gcccgacggt gagagggcgc agaccggccg tccggcccgc
    13801 cgccgtcgcg tgtgccgtgt gcgctgtgtg cggacgttcc ggtacgagca gccgccccgc
    13861 cgggtaggtg cgcggctcgt ccgggcgcca gggggcgatc gtcccgcgca gcagccaccg
    13921 tcccggtcgg ccgggcgccc gcggggcgga cggatggccg agcgcgaact gcaccaccag
    13981 accgccgaac tccccggccg ccgccgtgtc ccgcagccgc cgcgcggcgg gggacagcgc
    14041 cgtctcgtcg agccaggtca gcccctcgtc cccgccgccc acgacgaact ggtgcagcgc
    14101 cgaccgccgc cgcccgtgcg cggacgggtg gtgccaccgc ggcgggtgga agccgtggac
    14161 gtccccggtg gccatgtagc cgacgtcgtg ggagcgtccc gcgcggccga agcagaaccg
    14221 gccgaccatg agcgtcgtgg tccagtcgga cgccgggtcg acgtcgaaga cccgggcccg
    14281 gttgaccgtg gtggccaggt actcgttgta gtgcccccac aggtcgaccc gccgtcccac
    14341 caccgggtcg gcggtgtcga agtcgcccgc ggcgctctcg gcgctgacga tccgggcgtc
    14401 gaccgagaag tggccgttgc cggagaagtc ctcccccttg ccggagaagt cctcgccctt
    14461 ggcggacagg tcctcgcccc tggtggtgga gcgggtggcg gcggaacggg tggcggggga
    14521 gcgggtgtcg gcggagtggg gcccggccgc cgccggacgg accgcgccgc cgggccccgg
    14581 gcccagccgg tcgcgcgggt ccagccggtc cagtcggtcg aggctgtcgt ggtactcggc
    14641 ggccggccga tgcgccggga aggcccgccc gtcgccggtg agcgcggtgt tcgtggccag
    14701 gtcgacaagg ccgctgcggg gcccggtggg cagccggacc accgccgtgc cgcggaagtg
    14761 cagccggggc agatcgaaaa cgctcatgcg gtgtcctccg agccggggga gcctgccggg
    14821 ccgtccgagc cgatggggcc cctgcgggac gaccgtcccg gggcgacccc gcaggcgttc
    14881 acaccggacc gttcgagcgg gccggacggg tggtcgccag aacgcggcgc gccgtgcggg
    14941 gctcgtacca ctcgatgccg tgcgcgacgt cgatcgccga ctcgatcgcg ccctcgatcc
    15001 acgcgggctt cgacgagcag tgctcaccgg cgaagtggag cccccgctgc ggccgggccg
    15061 cctcccgccg ctccgcctcg cggaggacgg cctcctggcc ccagcggacc gtggccgcgc
    15121 cccgggacca ccggtgggtg ccccagtccc ggcccgccac gcccaggacc atgcccggac
    15181 ggcgcagctc ggggtggatc acgctcagct ccctggtgac gaccgcgacc cgctccgcct
    15241 cgctcagccg gctcagcgcg tcggcgtccg ggccgatcga atagctggcg agcagcaccg
    15301 cgccgagcgc cggatcgccc tcggcgggcg ggtagtaggt ctgccgcaca tggcccccgg
    15361 tgaaggaggc acccccgctg atcccgtcct tctcccagaa cggttcccgg cagtggaagg
    15421 ccagcttcgt cgccccccag taggccgtct gccggacgat gtccagcttc tcctggtcga
    15481 acccggtcag ccgcattctc cgcagcaccg ggaacgggat ggtgcacacc acgtagtcgc
    15541 agtccaacga ggtgaccttg gtgccctgac ggagtcgcag caggaccgat tcgtcccgca
    15601 catggatgcc cacgacctcc tgaccggtgg tgatcctgcc ccggatacgg gcggcgagcc
    15661 gccggggaag cgcctccatc ccgccgcgca gccgcacgat ggtggagctg gtctcgtcca
    15721 gcacatcatc gaggaaacgt tccagcctgg gcgggcagat ggaccgggcc cgggggtggt
    15781 cggcgaagaa ggcgtgcagg tcgatccggt tctcggcgcc gccgcaccgg tagggcgtca
    15841 catcgacgcg gtcgacgaag tccagcagtt ccacaccggt gtcgccggag agtcccgcac
    15901 agaagtgacg gggggcgatg gccctgatgc tggcgtccag ccaggcgccg aacaggaggg
    15961 tgtcgtcccg gtagttccgg tgcggcagcc gggcggcgaa ttcggcgacc aaggtcctgt
    16021 gcgcctcgcg tacccggaga taaccgccag acgtggcgag ataggcggcg tcgtccgaga
    16081 acagcgtccg gaattcatgt acctggttct ggaggccgag ttcggcgatg taatgcaggg
    16141 tgagccggtg tgccgaggga atccgcatcg cgccgagttc ggcgaaggga ccgttccggc
    16201 cgcgcccggc gaaatggtgg gtgtgaatcc ggccgccgac ctcctggctt ccttcgatga
    16261 tctggacctg gtgtcccagg cgttccaatt cataggccgc caccagaccg gcgataccgg
    16321 cgccgatgac cgtgaccttc ttgggtgcgg cgaccgcgcc gtccggcccg tcgatctccc
    16381 gcggggatac cgtcacagga ctcctccgat gccacgcctt tcccggaccc ggaaagagcg
    16441 atgccgggga ttgcttgtcc gccattgttc gggcggcggc gccccgcccg tatcccccgt
    16501 cgaacgccgg tacggacggg ttgagcgtcg gcccgtgacc gcgaacgggg tggcccggcg
    16561 ccgtgaccct gcgcgaacgc gcggggtttt cgccgcaccg cgaccgaggg gccgggacgg
    16621 ggcgatgctg cgtacgcggc tcgacgggcc ggacctgacc cgacgggccg gacacgggct
    16681 cagccgaccg cggcggctcc acagctgtaa acggctccac ggctccacgg ctgtacacgg
    16741 cttcacggct gtacgcggcc agcgagcagt acggggcggt gtgcgcgcgt tcgtcccgta
    16801 ccggcagcag cgccgcggca ccggcatgca cggccgcgga ccgagagcaa ccaggacccc
    16861 cagcgcgaga tccgggcacg agaaccccgc acgagaaccc cgacggaggc gacgttgaca
    16921 cgcgtgctga tcgctaccac accggctccc ggacacgtcg tcggcgtgtt cgcggtcgcg
    16981 cgggagctgg tccggcgcgg acatgaggtc cgctggtaca cgggcgaggt cttccgcgcc
    17041 cgggtggaac ggaccggggc acgcttcgaa cccatgcgcg ccgggctcga cttcggcggc
    17101 aggagccgcg aggaggcgtt cccggaacac gccggcctca ccggcctcac cagcttcacc
    17161 accggcatcc gggacatctt ctaccggacc gcaccgggcc agtcgcacga cctcctcgcg
    17221 gtgctcgacc ggttcccggc cgactgcctt ctcgccgacg acatgtgcta cggcgcctgc
    17281 ttcgccgccg agcgcaccgg caccccgctg gcctgggtga acaactccgt ctacatcctc
    17341 ggcagcaggg acaccccgcc gctcggctgg ggactgctgc cgaacgcctc accgctcggc
    17401 cgggtacgtg acgcgctgct ccgccgcctc accgaccgga tcgtgatgcg gggcctgcgc
    17461 cgcgaggccg accgcgcccg cgccctcgtg ggactggacc ggctgcgcac cgccgccctg
    17521 gagaacatcg cccgcccgcc ggacctctat ctgatgggca ccgtgccgtc cttcgagttc
    17581 ccccgcgcgg atctgcttcc gggcacccac ttcgtcggcg gactcctcgg accgcccccg
    17641 gacgacccgt tcgacccgcc cggctggtgg gaggagctgc gtggcggcga ccgccccgtg
    17701 gtgctgatca cccagggcac cacggcgaac gacgtcggcc ggctgctcgt ccccgccgtc
    17761 cgcgcgctgg cggacctgga cgccctcgtc gtggtcacca ccggaagcac cctcgacgtc
    17821 gaccggctgc ggccgttgcc gggaaacgtc cggctggaac ggttcgtccc ctaccaccat
    17881 ctgctgccgc acgtggcggt gatggtgacc aacgggggct acaacggcgt caacgcggcc
    17941 ctggcgcagg gggtgcccct ggtcgtcgcg ccgggctcgg aggagaaccc cgacgtcgcc
    18001 gcgcgggtcg cctggaccgg cgccggtgcc gtcctcggcc ggcgggccgt gtccgaggcc
    18061 cggctgcgcg ccgcggtcac cgccgtactg cacgacgggc gctaccgacg gcgcgcccgt
    18121 gccctggccc gggagcaccg gggccgcgac gccccgcgcc gggccgccga gctgatcgag
    18181 tccctggccg gagccccggg ccagatcccc atcggaggtg tcacacgatg aacgtcaccg
    18241 gacgcgccgc tgccgaacgc ttcaccaccg gaccggtcac caccggaccg gccgtcaccg
    18301 aaccggcggt cactgaaccg gccgtcgcgg ggcgggccgt cgccgggcgg acccgtctgg
    18361 cacaggctcc cgcgacgagc atgccgacgg acccggggcc gttcgactgc atgccggagc
    18421 tgctggccgc cgcgcgggtc gcgccggtcg tccgcatccc ctatctggac cggcacgcct
    18481 gggtcgtgtg cgatccggag ctggtccggg tcgcgctcac ccaccccgcg ctcgccaagg
    18541 acgtgaccct ggtccccgcc tggatgcgca agccggggct gatgctgggc tcgcagcccg
    18601 accccgagta cgcccgcacc atgatcatga gcgatggagc ccaccacgcc cggatccggc
    18661 ggctgcacgc gtcggtgctg agcccgcgca acaccgagac ctggggcgcg cgggtcggcg
    18721 tccaggtgga cggtttcctg gacgagctgg aacgttcccg ctcctccggg cccggcgagc
    18781 ccggcggaac gggcggaacc agcacgacgg gcgattccgg tgagcccggt gaggtcaacg
    18841 tggtcacggc ctacacccac cgcgtcccgc tcgcgttcat ctccgagatg ctgggcctgc
    18901 cccccggggc gcgggaacag ctccgttcca tcaccgacgt catcctctac tcctccgact
    18961 acccggaccg tgcccgcgcg gtcggggcgc tgtacggggc ggtcgagggc tgggtccgcg
    19021 acccggcccc gctgcgggac ggggtgatca cgggcctgct gtccgccgcc accggtccgg
    19081 acgcggcgga cggtccggac gcggcggtca ccgagggcga ggccgtcgtc tggaccctgg
    19141 cgatgatcat cacggggtac gagacgaccg ggagcctgat ctccaccgcg ctgtacgagg
    19201 cgctgcgacg gccctgcgac gagcgcccgc gcaccgacga cgagatcagg gcctgggtcg
    19261 aggagacgct gcgggtgcac cccccgtttc cccatccgac ctggcgtttc gccaccgagg
    19321 acatcgacat cggcgggttt ctgatccccc gtggagcccc ggtgcaggtc aatatcgcgg
    19381 cggcgaaccg gcgaccggac gagggagccg acagcttcac gccggagcgc gccgggcagg
    19441 gccacctctc cttcggcctc ggcccgcact actgcatcgg cgcctcgctg gcccggctgg
    19501 aggcacagat cgcggtccgc ggattcctgc gccggttccc gagggcgcgg ctgagcaccc
    19561 gtaccgccgt cgcctgggag tcggagtgga tgatccgcag gatgagcgcc ctgcccgccg
    19621 tgctgctctg acggcgccgg acctgctcac gttcacatgg atatgcggat atatagatat
    19681 gggggaacga tggctccgcg ctccgaagct ccgcgctccg acgcttctcg ctgcgacgct
    19741 ccgcgaaccg acgctccgga caccgacgct ccgcgcaccg atctgaaggc gctcgtgctc
    19801 gcgggcggct ccggctcccg gctgtggccg atcacccaca catcggccaa gcaactcgtc
    19861 ccggtcgcgg gcaaacccgt cctgttctac accctggagg ccatcgccgc cgcgggcatc
    19921 cgggagaccg gcgtcgtcgt cggtgacacg gccgccgaga tagagtccgc ggtcggcgac
    19981 ggctcgcggt tcggtctgga cgtgacctac ctgccgcagc gggcgcccct gggcctggcc
    20041 cacgccgtgc ggatcgcccg cgactacctc ggtgacgccg acttcctgat gtacctcggc
    20101 gacaacttcc tcgtcgacgg tgtcagcgcc gccgtgcggc ggttccggac ccaccgtccg
    20161 gacgcccaga tcatgctgac ccgggtggcg gacccgcgcg cgttcggcgt cgccgaactg
    20221 gaccccctcg gccgtgtcac cggcctggag gagaaacccg agcggccgag gagcgatctc
    20281 gcactggtcg gcgtctatct cttcaccccc cgggtgcacg acgccgtgtg ggggctcaag
    20341 ccctcgtggc gcggcgaact ggagatcacc gacgcgatcc agcagatgat cgacgagggc
    20401 cgccgggtgg acgccaccat cgtctccggc tactggaagg acaccggcaa tgtcgccgat
    20461 ctgctggagg tcaaccgcct ggtcctggac ggaatcgagt ccgaccgccc gggcgaggtc
    20521 cactccagcg aactgatcgg ccgggtggtg gtcgagaagg gcgcgaccgt caccggctcc
    20581 cggatcgtcg gcccggtggt cgtcgcggcg ggctccctgg tccgcgactc ccggatcggc
    20641 cccttcacct ccatcgaccg ggactgcgcg gtggtcgaca gtgagatcga ggactccatc
    20701 gtgctgcgcg gggcgaccat caccggggtg cggcgcgtcg agtgctcgct gatcggacgg
    20761 gaggccgagg tgctgtcgcg accccgcgcc gacggcggac agggggccca ccgcctcgtc
    20821 ctcggcgacc acagcacggt gcggatcgca tcatgaggat cctggtgacc ggcggcgtcg
    20881 gcttcatcgg ctcgcacttc gtccgcggcc gggtccacga ggacacggtg accgtgctcg
    20941 acagactgac ctacgccggg aaccccgcca acctggaacc cgtcgccggg cgcttcacct
    21001 tcgtccacgg cgacatctgt gacgcggccc tgctcaagga ggtcgtcccc ggccatgacc
    21061 tcgtcgtcaa cttcgccgcc gagtcccacg tcgaccggtc gatcgccggc gcgggcgagt
    21121 tcgtccgcac caacgtcctc ggggtgcaga ccctgctcca ggcatgcctc gacgcgggca
    21181 tcccgagggt cgtccaggtc tccaccgacg aggtgtacgg aagcatcgac accggctcct
    21241 gggacgagac cgccccgctc agcccgaact cgccctacgc cgcctccaag gcggccggcg
    21301 acctgatcgc gctcgcctac gcccggaccc accggctgcc ggtcagcatc acccgctgcg
    21361 gcaacaacta cggtccgtac cagtacccgg agaagctcgt cccgctcttc gtcacccatc
    21421 tgctcgacgg ccggaacgtg ccgctgtacg gagacggcgg ccatgtccgc gactggatcc
    21481 acgtcgacga ccactgccgc gccatccggc tggtcgccga acgcggcgcg ccgggcgagg
    21541 tctaccacgt cgccggaacc gccgaactga ccaacatcga actgaccctg cggctgctcg
    21601 acgcgctcca cgcccccggg cagcgcgtcg agccggtgcc cgaccgcaag gcccacgacc
    21661 gccgctactc cctcaccgac gccaagctgc gcgcactcgg ctacgccccg cggatcgcgt
    21721 tcgaacgggg cctcgccgag accgtcgcgt ggtacgccgc ccaccgcccc tggtgggagc
    21781 cgctgaagga acacgttccc ctggcgcgaa cagggctcac gccgtgaaac ggatcagcgc
    21841 cgtacgggac tggatgccca gcttccggta gatctgccgc agatggaacc ccaccgtgtg
    21901 cggggagatg tacagatggc gcgcggcctg ccggttggtg agtcccccgg ccaccagctc
    21961 cgccaccttc cgctccgtcg tggtcagact ctcccagccg gagaccgggc gtttcgtgtg
    22021 cgtccagtgc cgccgccgca caccgagttc gcgcagccgg gcccgtaccc gcgcggcgtc
    22081 ccactcgccg ccgagcgcgc cgtaggcgtt catcgcccgg tccagctcgc cgatcgcgcg
    22141 ctcgtgctcg ccgcggtcga gcagcagacc ggcgtggtcc tcggccaccg aggcgcgggc
    22201 ccacggattg cggtgcagca ggcccgcgcg gtccacaccc tccgcgtcct tcccggcgag
    22261 ggcgcgggcg tgcgccgccg aggcgagcac cgcggggacg caggggttgt gcgcctggag
    22321 ctggtccacc gtgtcgacga ccgtcttcac gaggcccggc agatccgccg cgagcgcgca
    22381 gcggacgcac caggcggcgg cggccgggtc cacgaggacg agttcccgga gcccgccggg
    22441 gcgttcaccg atctccgcga ggacgtccgc cgccgcgcgg gcgtccgtcc gggcctcggc
    22501 cagttgcgcg ctcagcagat cgcgcgcggc cgaccagggg ctggacgcgt gctgcggaaa
    22561 gccctggtcc agggttctga gatggtcctc ggcccgggcg agcgcccccc ggcgcagcgc
    22621 ggcgtgggcc agtaccagcc acgcctgcgg cgcgagcagc ggcacatgcg ggccgccgtc
    22681 cgcgccgacc ccggtccgcg ccgcctcctc ggcgtcgtcc aggcgtccca gggcgaggtg
    22741 cagcggcgcc cggagcaggg ccgcgacggc ggcggccggt gttctggccc cggtggccgc
    22801 cgaggacccg gcggcgccgc cgctccgggt cgagcgccgg accaccgccg cggcctcctc
    22861 gtactcgtcg gtcctggtca gcgcgaaggc gagaaaccag cgcgggtcga ggagccgtgc
    22921 gtcgtcgccc ccggggtcga gcgcgacggc ttcccgcagg gtctccacgg cggagcccac
    22981 cttcccgtcg cgccactggc cgaacgcatg gaagatcatc gcgacctgta cggcctgggc
    23041 atgggggtcg ggcgcactga tgatcttctg cgcgcgttcc ggagcggtgc tgtcgccggt
    23101 cagataggag gcggcgagat gggtgatcac agcctcgcgg cgcgggcggc cgccctgctg
    23161 cgccgccagc gcgtcatccg ccgcccggcg cgccatcgga gcgttcccga ggagcagcag
    23221 cgcggtcgac atggacgcct ggagcgcggc gatgtcctcg gcggccccgg tggtctcagc
    23281 ggtcccgacg acccgggcgc ccccgacggc cctggtgccc cccgcgctcc gggcgttctc
    23341 ggtgccccgg acggtcccgg tggtcccggt gccccgggtg gtccgggcgt cctcggcgga
    23401 gaccggggcg gcgagcccgg tggcctcgtc gatcgtctcc cgggccaggg tgatcgcccg
    23461 gtccagctcg cccgcccggg tgtacgcctc gaccgccgtc cgcgccagcc gcacccgttc
    23521 gggctgcccg ggggagagca gctccataca gcggatcgcc agccgtgccg cggtcggcgg
    23581 atcggtggcg agcagcttcc gggccccctc ggcgatgacg cgcagctcct ccgcgttgcc
    23641 gtggtgggcg acatggacga gctggagcgc ggcgcgctcc acaccgccgg ggcgcgacag
    23701 cagcatctcg gccgcctgcc gccgcagcag tacacagacc gggggcggca ccgagtcgag
    23761 cagaacccgc cagatcggct cgctgcggaa cgcgaggtcg tgctcaccgc agaccaggag
    23821 cccttggacg acggcctcgt ccaccgccgt cagcagaccg gccggcgcct ggccgagcag
    23881 cgtcgacaga tcctccggcg cgaacgggga gccgagtacc gccgccagcc gcagggccct
    23941 cagggtggat tcggagagtg accgcagatc tctccggacc catgcggaga accgtttcgg
    24001 caccggcgcc gggagacgga caccgccccc ggcgggaata cggccggggg cggtgccgtg
    24061 cacgatccgc gagaggccgt cgacgacgtg gacatcaccg tcctccacca gtccgcgcat
    24121 cagctcgatc accgcacggg gcgtgccgcc gacgcactcc gccagcgcga ggagcgccgg
    24181 gtcggggacg gctccggtgc agtcggtgac cagccgcgtc agcgcgtcgc ccgagagcgg
    24241 gcccagctcc cgcacggcct ccaccaggat gcggtcccgg agcccgccga cgcaggcccg
    24301 caccggatcg tacggagcgg tgtcgcgcat cgcgcccccg tccggatctc cggccgggtc
    24361 ccaggccggg ccccgggcag ggggccggtc ggaggtgaag gcgagcagcc acaccaccgg
    24421 gcgggtccgg aaggtcacga tcagatcgga cagcgccgtc agcgcggacg gaccggcccg
    24481 gtgcagatcg tcgaacacca cgagggtgcg ggtgggctcg gcgtccctgg ccagccgggc
    24541 ccgcgccgcc tcgatcacgg cacgggcacc ggcgggcgcc cggacggccc cgggggcggc
    24601 gccggacccg gagccgtccg gagcaccgcc gtcaccggtg tcggcaccgg caccaccgcc
    24661 gggaccgctt ccggcaccac ggccgggacc gcttccggcg tcaccgccag cgccgccgcc
    24721 gcggctcccg acgacggcga aactgttccg ctcggcggca ccgacggcct ccccgagcag
    24781 acgggtcttg cccgccccgg gcgcggcctc caccagaaga accacccccc ggcgggaatt
    24841 tgccacggcg cgcagatgcg cacagatctg cgcgagctgt cgttcccggc catgcatctg
    24901 cggcagtgtt cgtgcgttgg gcatccacgc gctccctatc acgatgacga cgacgggaag
    24961 gaacgagtac atcgccctcg tctcggtgca cgcgtggcgc acggtgcggg ttcgcgtcct
    25021 ttggccggac ggtgccgaag ccgccaccgg tacgacaggg aaagaccggg tggaacgggt
    25081 gcgggaaccg gccatggggg cggaccgcac gggtggcccg tccgcccgga ccggccaccg
    25141 ccgggcggac aggccgggag agacggccgg ggagaccggg agaaacgacc ggagagggtc
    25201 agacggcccg ggagaaccgc catacgttgt ccacccgcgt accgggaacg ccctcgggcg
    25261 acgagcacgg ccgctccacc gcctccaggg tctccacccg ccacccctcg ggcagcgcca
    25321 gccgctccag cagcccgtcg agggtcggga actccgcgtg gaaggggtgt tcgtgctgcc
    25381 acgacggcca ggcgccgtgc atcaccacga gcagcgtccc gcccggcgcg accgcctcgg
    25441 ccgccaggct cagcacccgg tcctggtcca acgccacggg cgactgaagg aactgcgcgt
    25501 tgaccaggtc gtaccgaccc tcggggaagg tcttccccag ctcgtgccgc tcccaggaga
    25561 gacgctcggc gaccccggcc tccccggcct cctcggcatg gagcgccgcc ctccgcagcg
    25621 cggtcgccga gatgtccacc ccggtgaccc gccagccccg ggcggccagc cagacggcgt
    25681 cggcgccttc cccgcacccg aggtcgagag ccgtccccgg ctccagcccc tcgacctcgc
    25741 gcaccagcag cggattgggg cgaccactcc atatccggtc gctgacctgg tagcgctcct
    25801 cccagaacac cgtcggatcg gcggagtggg ctgcggcatc gtgatcggcg gacgtggcgg
    25861 gtgtggtgga catgagcact cctcgtcgca acagcggaga cggcgatggc ccggccggtc
    25921 ggacgaccgg cgcggccacg gccagcatca ccccgccccc gtggaacacc aagaattgtt
    25981 gccggaacgg caacccgtgg tcccatccgc gcgcgctccg cccggttcct gcccccggat
    26041 tccccgtcgg cggttctcct tgacgctccg aagcgcaccg ccgcat
//
