BGC0000826: staurosporine biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 1,200,116 - 1,226,201 nt. (total: 26,086 nt).
This entry is originally from NCBI GenBank CM000914.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000826
Short description staurosporine biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
CM000914.1
1200116 - 1226201
via
Compounds
  • staurosporine
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
staurosporine Evidence:
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C28H26N4O3
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_p1107
  • EFG04593.1
 1200116 - 1201288 (-) Transcriptional regulator
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    • SCLAV_p1108
    • EFG04594.1
    • staC
    		 1201439 - 1203088 (-) Staurosporine biosynthesis monooxygenase StaC
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      • SCLAV_p1109
      • EFG04595.1
      • staMB
      		 1203190 - 1204065 (-) Staurosporine biosynthesis methyltransferase StaMB
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        • SCLAV_p1110
        • EFG04596.1
        • staE
        		 1204062 - 1204763 (-) Staurosporine biosynthesis 3,5-epimerase StaE
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          • SCLAV_p1111
          • EFG04597.1
          • staI
          		 1204835 - 1205944 (-) Staurosporine biosynthesis aminotransferase StaI
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            • SCLAV_p1112
            • EFG04598.1
            • staK
            		 1206008 - 1207015 (-) Staurosporine biosynthesis 4-ketoreductase StaK
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              • SCLAV_p1113
              • EFG04599.1
              • staJ
              		 1207017 - 1208675 (-) Staurosporine biosynthesis 2,3-dehydratase StaJ
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                • SCLAV_p1114
                • EFG04600.1
                • staMA
                		 1208787 - 1209686 (-) Staurosporine biosynthesis methyltransferase StaMA
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                  • SCLAV_p1115
                  • EFG04601.1
                  • staP
                  		 1209712 - 1211157 (-) Staurosporine biosynthesis cytochrome P450 StaP
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                    • SCLAV_p1116
                    • EFG04602.1
                    • staD
                    		 1211285 - 1214902 (-) Staurosporine biosynthesis chromopyrrolic acid synthase StaD
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                      • SCLAV_p1117
                      • EFG04603.1
                      • staO
                      		 1214994 - 1217036 (-) Staurosporine biosynthesis L-amino acid oxidase StaO
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                        • SCLAV_p1118
                        • EFG04604.1
                        • staG
                        		 1217039 - 1218346 (+) Staurosporine biosynthesis N-glycosyltransferase StaG
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                          • SCLAV_p1119
                          • EFG04605.1
                          • staN
                          		 1218343 - 1219746 (+) Staurosporine biosynthesis Cytochrome P450 StaN
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                            • SCLAV_p1120
                            • EFG04606.1
                            • staA
                            		 1219805 - 1220971 (+) Staurosporine biosynthesis glucose-1-phosphate thymidyltransferase StaA
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                              • SCLAV_p1121
                              • EFG04607.1
                              • staB
                              		 1220968 - 1221942 (+) Staurosporine biosynthesis dTDP-glucose 4,6-dehydratase StaB
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                                • SCLAV_p1122
                                • EFG04608.1
                                • staR
                                		 1221932 - 1225210 (-) Staurosporine biosynthesis transcriptional activator StaR
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                                  • SCLAV_p1123
                                  • EFG04609.1
                                  		 1225314 - 1226201 (-) Putative methyltransferase
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                                    Biosynthesis information
                                    Annotation changelog

                                    Entry version: 4

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Updated bioactivity data
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2015-06-12
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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