BGC0000829

BGC0000829: violacein biosynthetic gene cluster from Chromobacterium violaceum

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Location: 1 - 10,094 nt. (total: 10,094 nt).
This entry is originally from NCBI GenBank AF172851.1.

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core biosynthetic genes

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transport-related genes

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Gene details

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General

Compounds

Genes

Biosynthesis

History

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000829
Short description	violacein biosynthetic gene cluster from Chromobacterium violaceum
Status	Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	other (other)
Loci	AF172851.1 via Knock-out studies
Compounds	violacein
Species	Chromobacterium violaceum [taxonomy]
References	[1] Biosynthesis of violacein: intact incorporation of the tryptophan molecule on the oxindole side, with intramolecular rearrangement of the indole ring on the 5-hydroxyindole side. Momen AZ et al., Biosci Biotechnol Biochem (2000) PMID:10803951 [2] Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum. August PR et al., J Mol Microbiol Biotechnol (2000) PMID:11075927 [3] Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Brady SF et al., Org Lett (2001) PMID:11418029 [4] Chromobacterium violaceum: a review of pharmacological and industiral perspectives. Durán N et al., Crit Rev Microbiol (2001) PMID:11596879 [5] Genetic analysis of violacein biosynthesis by Chromobacterium violaceum. Antônio RV et al., Genet Mol Res (2004) PMID:15100990 [6] Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis. Sánchez C et al., Chembiochem (2006) PMID:16874749 [7] Antioxidant properties of violacein: possible relation on its biological function. Konzen M et al., Bioorg Med Chem (2006) PMID:17011197 [8] In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. Balibar CJ et al., Biochemistry (2006) PMID:17176066 [9] Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function. Shinoda K et al., Chem Commun (Camb) (2007) PMID:17925955 [10] N-acylhomoserine lactone regulates violacein production in Chromobacterium violaceum type strain ATCC 12472. Morohoshi T et al., FEMS Microbiol Lett (2008) PMID:18177311 [11] Anthranilate synthase subunit organization in Chromobacterium violaceum. Carminatti CA et al., Genet Mol Res (2008) PMID:18949702 [12] Stable high level expression of the violacein indolocarbazole anti-tumour gene cluster and the Streptomyces lividans amyA gene in E. coli K12. Ahmetagic A et al., Plasmid (2010) PMID:19962399 [13] Novel tryptophan metabolites, chromoazepinone A, B and C, produced by a blocked mutant of Chromobacterium violaceum, the biosynthetic implications and the biological activity of chromoazepinone A and B. Mizuoka T et al., Org Biomol Chem (2010) PMID:20490411 [14] Chromobacterium violaceum and its important metabolites--review. Durán M et al., Folia Microbiol (Praha) (2010) PMID:21253897 [15] Violacein and related tryptophan metabolites produced by Chromobacterium violaceum: biosynthetic mechanism and pathway for construction of violacein core. Hoshino T, Appl Microbiol Biotechnol (2011) PMID:21779844

Chemical products information

violacein Evidence:

(no structure information available)

Chemical database entries
ChemSpider

List of genes involved in compound(s) production

Identifiers	Position	Product	Functions	Evidence	Extra
AAD51807.1	123 - 1751 (+)	unknown			copy AA seq copy Nt seq
AAD51808.1 vioA	1969 - 3225 (+)	tryptophan 2-monooxygenase	Scaffold biosynthesis	Knock-out	copy AA seq copy Nt seq
AAD51809.1 vioB	3300 - 6296 (+)	polyketide synthase-like	Scaffold biosynthesis	Knock-out	copy AA seq copy Nt seq
AAD51810.1 vioC	6298 - 7587 (+)	monooxygebase	Tailoring	Knock-out	copy AA seq copy Nt seq
AAD51811.1 vioD	7587 - 8708 (+)	hydroxylase	Tailoring	Knock-out	copy AA seq copy Nt seq

Biosynthesis information

Annotation changelog

Entry version: 4

Date

Changes

Submitters

Reviewers

2022-10-07

Update chemical activity to schema version 2.11

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Entry version: 3

Date

Changes

Submitters

Reviewers

2022-09-15

Corrected gene identifiers

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Entry version: 2

Date

Changes

Submitters

Reviewers

2019-10-16

Migrated from v1.4

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Entry version: 1

Date

Changes

Submitters

Reviewers

2015-06-12

Submitted

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