LOCUS       BGC0000833             40210 bp    DNA     linear   BCT 25-JUL-2016
DEFINITION  Streptomyces rishiriensis strain DSM 40489 hypothetical protein
            gene, partial cds; putative FK506-binding protein gene, complete
            cds; coumermycin A1 biosynthetic gene cluster, complete sequence;
            and DNA gyrase subunit B (gyrB-Rc) and DNA gyrase subunit B (parYR)
            genes, complete cds.
ACCESSION   BGC0000833
VERSION     BGC0000833
KEYWORDS    .
SOURCE      Streptomyces rishiriensis
  ORGANISM  Streptomyces rishiriensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 40210)
  AUTHORS   Wang,Z.X., Li,S.M. and Heide,L.
  TITLE     Identification of the coumermycin A(1) biosynthetic gene cluster of
            Streptomyces rishiriensis DSM 40489
  JOURNAL   Antimicrob. Agents Chemother. 44 (11), 3040-3048 (2000)
   PUBMED   11036020
REFERENCE   2  (bases 1 to 40210)
  AUTHORS   Schmutz,E., Muhlenweg,A., Li,S.M. and Heide,L.
  TITLE     Resistance genes of aminocoumarin producers: two type II
            topoisomerase genes confer resistance against coumermycin A1 and
            clorobiocin
  JOURNAL   Antimicrob. Agents Chemother. 47 (3), 869-877 (2003)
   PUBMED   12604514
REFERENCE   3  (bases 1 to 40210)
  AUTHORS   Scmutz,E., Muehlenweg,A., Wang,Z.-X., Li,S.-M. and Heide,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-NOV-1999) Pharmazeutische biologie, Pharmazeutisches
            Institut, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen
            72076, Germany
REFERENCE   4  (bases 1 to 40210)
  AUTHORS   Wang,Z.-X., Li,S.-M. and Heide,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-FEB-2000) Pharmazeutische biologie, Pharmazeutisches
            Institut, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen
            72076, Germany
REFERENCE   5  (bases 1 to 40210)
  AUTHORS   Wang,Z.-X., Li,S.-M. and Heide,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2000) Pharmazeutische biologie, Pharmazeutisches
            Institut, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen
            72076, Germany
  REMARK    Amino acid sequence updated by submitter
REFERENCE   6  (bases 1 to 40210)
  AUTHORS   Wang,Z.-X., Li,S.-M. and Heide,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-OCT-2000) Pharmazeutische biologie, Pharmazeutisches
            Institut, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen
            72076, Germany
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 40210)
  AUTHORS   Wang,Z.-X., Li,S.-M. and Heide,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2001) Pharmazeutische biologie, Pharmazeutisches
            Institut, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen
            72076, Germany
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 40210)
  AUTHORS   Wang,Z.-X., Li,S.-M. and Heide,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2002) Pharmazeutische biologie, Pharmazeutisches
            Institut, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen
            72076, Germany
  REMARK    Sequence update by submitter
REFERENCE   9  (bases 1 to 40210)
  AUTHORS   Siebenberg,S. and Heide,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-SEP-2011) Pharmazeutische biologie, Pharmazeutisches
            Institut, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen
            72076, Germany
  REMARK    Sequence update by submitter
COMMENT     ##antiSMASH-Data-START##
            Version  :: 8.dev-5707d64f
            Run date :: 2025-08-15 17:55:58
            ##antiSMASH-Data-END##
            On or before Sep 21, 2011 this sequence version replaced
            AF205853.1, AF235050.3.
FEATURES             Location/Qualifiers
     source          1..40210
                     /db_xref="taxon:68264"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces rishiriensis"
                     /strain="DSM 40489"
                     /type_material="type strain of Streptomyces rishiriensis"
     region          1..40210
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /candidate_cluster_numbers="4"
                     /contig_edge="True"
                     /product="PKS-like"
                     /product="aminocoumarin"
                     /region_number="1"
                     /rules="(t2pks2 or ksIII)"
                     /rules="(novK or novJ or novI or novH or SpcDK_cou)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..40210
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000833"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..40210
                     /SMILES="NC(Cc1ccc(O)cc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2pks2 or ksIII)"
                     /detection_rules="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /detection_rules="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /kind="neighbouring"
                     /product="PKS-like"
                     /product="aminocoumarin"
                     /protoclusters="1"
                     /protoclusters="2"
                     /protoclusters="3"
                     /tool="antismash"
     cand_cluster    1..34891
                     /SMILES="NC(Cc1ccc(O)cc1)C(=O)O"
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(t2pks2 or ksIII)"
                     /kind="single"
                     /product="PKS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..34891
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[13823:14891](+)"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      13824..14891
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="1"
     cand_cluster    1..20627
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /kind="single"
                     /product="aminocoumarin"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..20627
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5930:10627](+)"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      5931..10627
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="2"
     gene            2307..2960
                     /gene="couE"
     CDS             2307..2960
                     /codon_start=1
                     /gene="couE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LmbU"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to NovE protein from Streptomyces
                     spheroides"
                     /product="CouE"
                     /protein_id="AAR11885.1"
                     /sec_met_domain="LmbU (E-value: 2.6e-84, bitscore: 272.9,
                     seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVASGQTASKAGGSGATPVRPTAGDATPVDSRKSSHASCLGVEVS
                     AERTRLQIPQDLSLEAWCRLGGRILTVCDSSAWWIGDWLVFGQNQYGDRYRRAMEKTKL
                     DYQTLRNYAWVARKFEPSRRRDRLTFQHHMEVASLSQAEQDHWLDFAVRLNWSRNQLRK
                     QIRASISGEEDDLRRHVQLSLQLDELRLERWREAARGSNLTLTDWILFVVDEAI"
     misc_feature    2307..35365
                     /note="coumermycin A1 biosynthetic gene cluster"
     misc_feature    2862..2864
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2871..2873
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2934..2936
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4114..5073
                     /gene="couG"
                     /note="cumA"
     CDS             4114..5073
                     /codon_start=1
                     /gene="couG"
                     /gene_functions="regulatory (extras) StrR_like: StrR-like
                     pathway specfic regulators"
                     /gene_kind="regulatory"
                     /note="putative regulatory protein; CouG"
                     /product="CouG"
                     /protein_id="AAG29778.1"
                     /transl_table=11
                     /translation="MSNSGDEEMTSILPKAIGKGERVPIGSLFPSQQLLRSGESTEHIR
                     ALVETEEVLPPIVVHRETRRVIDGMHRLRAARFRGDEWIEVVFIDDASADVFVLAVELN
                     RAHGLPLTMAERKSAAARIMDSHPHWSDRKIARTTGLAASTVASLRSHSIAGTLERRTG
                     QDGRTRPKDGTEGRRRASELLAQNPNASVREVAKAARISVGTASNVRARLRRGEPAITA
                     LQQAALTPRPASATQRTGPDYSRVLQSLRNNPSLRFNDVGRHLLRLLGGAAPGSVEQIA
                     QIADSVPEHCRVMVIDMARECAAAWQHLADRLAGRDTA"
     gene            5410..5625
                     /gene="couY"
                     /note="cumB"
     CDS             5410..5625
                     /codon_start=1
                     /gene="couY"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009: mbtH-like protein"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to Mycobacterium tuberculosis MbtH"
                     /product="CouY"
                     /protein_id="AAG29779.1"
                     /transl_table=11
                     /translation="MATNPFDDENGVYLLLVNDEGQHSLWPSFAALPKGWTVILDEASR
                     QECLDYVNEHWTDMRPLSLQPAMGDE"
     gene            5931..7730
                     /gene="couH"
                     /note="cumC"
     CDS             5931..7730
                     /NRPS_PKS="Domain: AMP-binding (26-424). E-value: 7.2e-101.
                     Score: 329.7. Matches aSDomain:
                     nrpspksdomains_couH_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (530-596). E-value: 5.3e-18. Score:
                     57.0. Matches aSDomain: nrpspksdomains_couH_PCP.1"
                     /codon_start=1
                     /gene="couH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /note="CouH"
                     /product="acyl-CoA synthetase"
                     /protein_id="AAG29780.1"
                     /sec_met_domain="novH (E-value: 0.0, bitscore: 1113.4,
                     seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.9e-12, bitscore:
                     38.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSKGLNKASDRSATTRTASATLAELWERTVRSRPSSPAIVSNSE
                     TLSYDEVNARANQLARLLLSEGAGPGRVVALALPRSSRMVISVLAVAKAGAAFLPVDVN
                     YPEQRIAYMLADAEPALLCTIRTAVPKLPADIGVPQLVLDSAEQTATLDALPDTDVTED
                     ERGGSLAATNLAYVIYTSGSTGRPKGVALTGAGLPALAAAKVATMQVTEDSRVLQFASP
                     SFDAYVTELLATFTSGATLVVPGSDTLVGDPLAKVLREGQVSHAVLPPAAVATMSPDAA
                     PDLRVLVVAGEECPAGLVEQWSPGRLLVNAYGPTECTVCATMTGPLTPTDEVTIGRPIP
                     GVSVHILDDELLPVAAGEIGELYLSGAGLARGYLNRPDVTAHVFVANPFAADGERMYRT
                     GDLASMRADGDILFHGRIDDQVELRGFRIELGEVESVLSQHPDVAQAVAVLRAGEDDGP
                     QLLAYVVPTHGTTPAAGELREHAGRYLPDYMVPSVYATIDAIPVTPSGKTDRAALPPIK
                     TTRPAGQKPRTSAEKILFDIFRDLFGLGEIDVRSNFFEMGGNSILAVDLIQRAQEAGLV
                     LLPRTVIDHPTIEQLAAIANLGE"
     aSDomain        6009..7202
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couH_AMP-binding.1"
                     /evalue="7.20E-101"
                     /label="couH_AMP-binding.1"
                     /locus_tag="couH"
                     /protein_end="424"
                     /protein_start="26"
                     /score="329.7"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="WERTVRSRPSSPAIVSNSETLSYDEVNARANQLARLLLSEGAGPG
                     RVVALALPRSSRMVISVLAVAKAGAAFLPVDVNYPEQRIAYMLADAEPALLCTIRTAVP
                     KLPADIGVPQLVLDSAEQTATLDALPDTDVTEDERGGSLAATNLAYVIYTSGSTGRPKG
                     VALTGAGLPALAAAKVATMQVTEDSRVLQFASPSFDAYVTELLATFTSGATLVVPGSDT
                     LVGDPLAKVLREGQVSHAVLPPAAVATMSPDAAPDLRVLVVAGEECPAGLVEQWSPGRL
                     LVNAYGPTECTVCATMTGPLTPTDEVTIGRPIPGVSVHILDDELLPVAAGEIGELYLSG
                     AGLARGYLNRPDVTAHVFVANPFAADGERMYRTGDLASMRADGDILFHGRIDDQVELR"
     aSModule        6009..7718
                     /complete
                     /domains="nrpspksdomains_couH_AMP-binding.1"
                     /domains="nrpspksdomains_couH_PCP.1"
                     /locus_tags="couH"
                     /monomer_pairings="Tyr -> Tyr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6195..6236
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0001"
                     /evalue="1.50E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="couH"
                     /protein_end="102"
                     /protein_start="88"
                     /score="15.1"
                     /tool="antismash"
                     /translation="LAVAKAGAAFLPVD"
     CDS_motif       6453..6509
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0002"
                     /evalue="9.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="couH"
                     /protein_end="193"
                     /protein_start="174"
                     /score="30.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVALT"
     CDS_motif       6864..6890
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0003"
                     /evalue="1.10E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="couH"
                     /protein_end="320"
                     /protein_start="311"
                     /score="11.5"
                     /tool="antismash"
                     /translation="YGPTECTVC"
     CDS_motif       6996..7082
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0004"
                     /evalue="9.40E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="couH"
                     /protein_end="384"
                     /protein_start="355"
                     /score="46.7"
                     /tool="antismash"
                     /translation="AGEIGELYLSGAGLARGYLNRPDVTAHVF"
     CDS_motif       7167..7232
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0005"
                     /evalue="9.00E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="couH"
                     /protein_end="434"
                     /protein_start="412"
                     /score="33.8"
                     /tool="antismash"
                     /translation="FHGRIDDQVELRGFRIELGEVE"
     aSDomain        7521..7718
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couH_PCP.1"
                     /evalue="5.30E-18"
                     /label="couH_PCP.1"
                     /locus_tag="couH"
                     /protein_end="596"
                     /protein_start="530"
                     /score="57.0"
                     /tool="antismash"
                     /translation="EKILFDIFRDLFGLGEIDVRSNFFEMGGNSILAVDLIQRAQEAGL
                     VLLPRTVIDHPTIEQLAAIAN"
     gene            7734..8957
                     /gene="couI"
                     /note="cumD"
     CDS             7734..8957
                     /codon_start=1
                     /gene="couI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /note="CouI"
                     /product="cytochrome P-450"
                     /protein_id="AAG29781.1"
                     /sec_met_domain="novI (E-value: 5.6e-260, bitscore: 852.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 2.7e-15, bitscore: 47.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRPMVSADELEDIDLASPILHAEYELDAVFRHLRANRPMYWQQ
                     PRGEQPGFWVISRYADVNEVYKDKAHFTTENGNALATLLTGGDSASGAMLAVTDGVRHH
                     QVRNLLSKGFSPQMLELIANSLRETVDGLLLAALDRGECDAARDISAKVPLGAICDLLE
                     IPQTDREYLLGLTAHAWSTDYADEPPEESWVAKNEILLYFSKLLKERRGGDRDDMVSLL
                     ANCRIDGHPLNAAEQIANCYGLMIGGDETGRHAITGTVLALIENPDQWRALKNGDVDLK
                     TATEEALRWTVPSLHGGRKATGDVVINGQQIKAGEVVSVWISSANRDETVFDAADEFKL
                     ARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYSSILHGMS
                     SLPIKITA"
     misc_feature    8853..8855
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9117..9893
                     /gene="couJ"
                     /note="cumE"
     CDS             9117..9893
                     /NRPS_PKS="Domain: PKS_KR (13-185). E-value: 2.6e-22.
                     Score: 71.6. Matches aSDomain:
                     nrpspksdomains_couJ_PKS_KR.1"
                     /codon_start=1
                     /gene="couJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic"
                     /note="similar to 3-ketoacyl-[ACP]-reductase"
                     /product="CouJ"
                     /protein_id="AAG29782.1"
                     /sec_met_domain="novJ (E-value: 5.7e-153, bitscore: 498.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.2e-38, bitscore:
                     122.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPAASAVACEPVAMVTGAGRGIGAATAERLAAEGMAVIVVDRV
                     EQDTTATVSAIRAAGGRASGLGCDVSVAQAVTATVASAVEEFGHLDVLVNCAGITQDRL
                     LLTMSDQEWDRVLDVNLGGSMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTNYATA
                     KGAIAGFTRTLAAEFGPHGVTVNSIAPGFVATPMVAELTERLGVDRDTVLLEAAMSSAV
                     GRIGTPEEIAAVVAFVTRPESGYLTGETIHVEGGRR"
     aSDomain        9156..9671
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couJ_PKS_KR.1"
                     /evalue="2.60E-22"
                     /label="couJ_PKS_KR.1"
                     /locus_tag="couJ"
                     /protein_end="185"
                     /protein_start="13"
                     /score="71.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAMVTGAGRGIGAATAERLAAEGMAVIVVDRVEQDTTATVSAIRA
                     AGGRASGLGCDVSVAQAVTATVASAVEEFGHLDVLVNCAGITQDRLLLTMSDQEWDRVL
                     DVNLGGSMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTNYATAKGAIAGFTRTLAA
                     EFGPHGVTV"
     CDS_motif       9165..9239
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couJ_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="couJ"
                     /protein_end="41"
                     /protein_start="16"
                     /score="11.1"
                     /tool="antismash"
                     /translation="VTGAGRGIGAATAERLAAEGMAVIV"
     CDS_motif       9546..9605
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couJ_0002"
                     /evalue="1.20E-06"
                     /label="PKSI-KR_m4"
                     /locus_tag="couJ"
                     /protein_end="163"
                     /protein_start="143"
                     /score="21.0"
                     /tool="antismash"
                     /translation="INFSSVAARGNAGQTNYATA"
     gene            9890..10627
                     /gene="couK"
                     /note="cumF"
     CDS             9890..10627
                     /codon_start=1
                     /gene="couK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic"
                     /note="CouK"
                     /product="putative reductase"
                     /protein_id="AAG29783.1"
                     /sec_met_domain="novK (E-value: 1.4e-132, bitscore: 431.7,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGVAVVAGGGEHTGPAVAVRLAGRGFDVALLDTEFTAADKTVRQ
                     IEESGRRCVTVEAELTDTRSVGAAFGQVRSALSSPVVLVTCVGPGPVPDGSPEDELADE
                     QRYGVVRRALRSAFVCCQAGAGHLLHHRWGRIIIVTEPVDAGGNAWRTSQPVLAGLIGF
                     TRSAALELARSGITVNLIAPAESAVDSRAPAHQPAVNVGAGSYAEGVAHVTAFLIDDQA
                     VGITGQEIYLAAAQAGVPLLRER"
     gene            10634..12223
                     /gene="couL"
                     /note="cumG"
     CDS             10634..12223
                     /NRPS_PKS="Domain: AMP-binding (17-421). E-value: 4.7e-76.
                     Score: 247.9. Matches aSDomain:
                     nrpspksdomains_couL_AMP-binding.1"
                     /codon_start=1
                     /gene="couL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /note="CouL"
                     /product="putative ligase"
                     /protein_id="AAG29784.2"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-77, bitscore:
                     250.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANRDHGPEHYVTRILDEAARDGARPVVRWRDTVITGTELHRSVR
                     RVATALREAGVARDHAVAILTQVNSPWMLVVRYAAHLLGASVVYITGANHGTVTHDLPV
                     TTRVRMMREAGASVLVFDERNAQLAETIRETVPDKLVLCGLGHPASGTVTADGRPVEDV
                     AVEFPAETPELAMVLYTSGTTGQPKGVCKPFGAWNATVVGLAGQPRPRQTYLAMTAVSH
                     TVGMVVDIALAAGGSVLLREKFDPTDFLRDVVTHRVTDTFMGVPQLYAILNHPDVRTTD
                     LSSLQHLVYVGCPASPERLREAVTVFPGVLWQSYGSTETGRIAMLREDDHDHPELLATV
                     GRPMPGVTIAIRDPQTGRDLPVNEIGEVVVHSPNNMAGYIGDPEGTTRVVRDGWVHTGD
                     MGSVDERGYVRLFGRMHEMVKVQDTRVSPTEVEKVLVGCPGVVDACVYGHRRPDLIEEL
                     HAAVVLSTEDAPSFAALRDHVAQTMTPTHAPVRFVRWRQFPINNTGKTDRLRIREVSAE
                     ARGEGPDVLVDR"
     aSDomain        10685..11896
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couL_AMP-binding.1"
                     /evalue="4.70E-76"
                     /label="couL_AMP-binding.1"
                     /locus_tag="couL"
                     /protein_end="421"
                     /protein_start="17"
                     /score="247.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EAARDGARPVVRWRDTVITGTELHRSVRRVATALREAGVARDHAV
                     AILTQVNSPWMLVVRYAAHLLGASVVYITGANHGTVTHDLPVTTRVRMMREAGASVLVF
                     DERNAQLAETIRETVPDKLVLCGLGHPASGTVTADGRPVEDVAVEFPAETPELAMVLYT
                     SGTTGQPKGVCKPFGAWNATVVGLAGQPRPRQTYLAMTAVSHTVGMVVDIALAAGGSVL
                     LREKFDPTDFLRDVVTHRVTDTFMGVPQLYAILNHPDVRTTDLSSLQHLVYVGCPASPE
                     RLREAVTVFPGVLWQSYGSTETGRIAMLREDDHDHPELLATVGRPMPGVTIAIRDPQTG
                     RDLPVNEIGEVVVHSPNNMAGYIGDPEGTTRVVRDGWVHTGDMGSVDERGYVRLFGRMH
                     EMVKV"
     CDS_motif       11156..11206
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couL_0001"
                     /evalue="1.80E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="couL"
                     /protein_end="191"
                     /protein_start="174"
                     /score="23.5"
                     /tool="antismash"
                     /translation="AMVLYTSGTTGQPKGVC"
     CDS_motif       11714..11794
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couL_0002"
                     /evalue="4.90E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="couL"
                     /protein_end="387"
                     /protein_start="360"
                     /score="15.7"
                     /tool="antismash"
                     /translation="PVNEIGEVVVHSPNNMAGYIGDPEGTT"
     gene            12237..13445
                     /gene="couM"
                     /note="cumH"
     CDS             12237..13445
                     /codon_start=1
                     /gene="couM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /note="CouM"
                     /product="glycosyl transferase"
                     /protein_id="AAG29785.1"
                     /sec_met_domain="MGT (E-value: 2.8e-116, bitscore: 379.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFTSLPGIGHLFPMVPLAWALQAAGHTVLVATDREFLPVVTG
                     AGLPAAAVRDPVDPVELFKPVSLSGLSGLLGLSGGPVSPAERTGHRCAEIGVRALAAVR
                     ALVDAWRPDLVIAEPMELAGPAAATIAGVPWVRHSYGLIPPERLLSAAAAALDSELAVR
                     GLSPWAEPAGTIDVCPDSLQPSDAVATMPMPMRYVPYNGPAVVPDWLLAGPSPRPRVCL
                     TLGTSLPRRNPRVAPLWRLLLDELVALGQEVVIAIDESHRSLLGHLPGGVRAARIPLCD
                     LLPTCTAIVHHGGSGSTMAAAAFGVPQLVVPHFADHFANAERIIAVGAGTSLPHDTDDL
                     ARITAACALIVDDGPHRAISARLAEENASRPKPTEVAQDLVALVLEHSQDVLRPQHASQ
                     GRQ"
     gene            13526..13813
                     /gene="couN1"
                     /note="cumI"
     CDS             13526..13813
                     /NRPS_PKS="Domain: PP-binding (32-82). E-value: 4.7e-07.
                     Score: 22.3. Matches aSDomain:
                     nrpspksdomains_couN1_PP-binding.1"
                     /codon_start=1
                     /gene="couN1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN1"
                     /product="hypothetical protein"
                     /protein_id="AAG29786.1"
                     /sec_met_domain="PP-binding (E-value: 2.5e-07, bitscore:
                     22.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTGRTELEHVLTRLEMLLNDVWDQRPAGVAMSATAPLVSLGVDS
                     LTLALLLDNVGREFHIDWTADTRLGGAISLRSLADLVLRRDGGPAAAAEA"
     aSDomain        13622..13771
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couN1_PP-binding.1"
                     /evalue="4.70E-07"
                     /label="couN1_PP-binding.1"
                     /locus_tag="couN1"
                     /protein_end="82"
                     /protein_start="32"
                     /score="22.3"
                     /tool="antismash"
                     /translation="SATAPLVSLGVDSLTLALLLDNVGREFHIDWTADTRLGGAISLRS
                     LADLV"
     gene            13824..14891
                     /gene="couN2"
                     /note="cumJ"
     CDS             13824..14891
                     /codon_start=1
                     /gene="couN2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: ksIII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic"
                     /note="CouN2; similar to Streptomyces peucetius DpsC"
                     /product="3-ketoacyl-[ACP]-synthase"
                     /protein_id="AAG29787.2"
                     /sec_met_domain="ksIII (E-value: 2.1e-77, bitscore: 251.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSGTYLAGIGVFRPKTKSVDAAVRQGLVSKESADASGITGVSV
                     AGDVSPAEIALIAARQALHSSGLSADDIGLLLHTGVWHQGPDGWGPQYYLQRHLLGDDL
                     LAVELRHGCNGTFSALELAVPYVKCAPHAGGVLITASDNFGTPLIDRWNPGEGMAYLGD
                     GAGAVVLGSSPGFAELLSICTTTFSGMEEVHRAGEPLFPPGATTGTFLDYGARAARFQQ
                     RATDDGTWVQLLLGHQKHNVECVGQALHEAGVDARDIKTVLIHSMPRQAAASYLKILGF
                     SLDRSTWEFSRTTGHLGAGDHLAALYHLLSTGEVGPGDNLLLCGSSPGVTYKAAVIRIL
                     DTAALRNQEARPDGL"
     gene            14881..16011
                     /gene="couN3"
                     /note="proA"
     CDS             14881..16011
                     /codon_start=1
                     /gene="couN3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN3"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="AAG29788.2"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-14, bitscore:
                     45.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 8.1e-27, bitscore:
                     84.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.8e-37, bitscore:
                     119.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFDLSPQQQQRVDHMRAGAGKLPATEPDGIAGKDSWLAAAELGM
                     TGLCLPTEHGGGGLGALDTALCLEAFCAGGADTGLAFGIAAHLLACGTVLADHAGEPVR
                     AELLQGLASGTVVAANAMTEDDAGSDLSRLTTTAVADGDSYVLNGRKSFVSNAPLADVF
                     ITYAATAPSAGYLGMSAFAVPRTLPGLQVGSLLAKMGLNGCAAAQVEFTDCKVPGRYLL
                     GPENQGNSVFQRSMTWERACLPAIYLGAMEGQLAQCVDHARSRKQFGRSIGNFQAISHR
                     LATMKLRLETSRLLLYRACWYLDQGRPAVEAAALAKTAVAEAAVANALDAVQVFGARGC
                     LAADGIGQQLQNAIPLNIFSGTTEMQREVVAKSMGL"
     misc_feature    16006..16008
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16130..17635
                     /gene="couN4"
                     /note="proB"
     CDS             16130..17635
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 1.1e-92.
                     Score: 302.7. Matches aSDomain:
                     nrpspksdomains_couN4_AMP-binding.1"
                     /codon_start=1
                     /gene="couN4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN4"
                     /product="acyl-CoA synthetase"
                     /protein_id="AAG29789.1"
                     /sec_met_domain="AMP-binding (E-value: 2.9e-97, bitscore:
                     316.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERRGLHDLLSASAARTPDAPAVVGPAGSMSYGELDERADALAG
                     RLSGQGISKGDRVLIWSPKSANAIAAMQAVLRLGAIYIPVDPLTPPERFLVIARESGAL
                     ALCAPEDLSARVPSPLRDCLACVDLDAAPVPDALPRTPVSTCVEPDDLAYILYTSGSTG
                     TPKGVCISHRSALAFIDWAVAELAPGPQDRFANHSGLSFDLSVLDLYAAFTVGAAVCLI
                     QPEFAYVPEGLVEFLHRERISVWYSVPSALILMLRDGGLLDRPAPGTLRALLFAGEPFP
                     IGPLRALAAWSDARLLNLYGPTETNVCTYHEVRPADLARDLPVPIGKPCSGDRVWAIRA
                     DGSEAEPGEEGELVVSGPTVFAGYWGRQPQEGPYATGDRVKVRPDGSFDYLGRRDGMVK
                     IRGHRIELGDVVAALYSHQGVAEAAVIAVGDGLDRVLAAFVVRSRGSAFGNVALRRHLA
                     GRLAPHMIPGDIRFVDRLPHNDRGKLDLAALQRPLHGPQKVQG"
     aSDomain        16166..17332
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couN4_AMP-binding.1"
                     /evalue="1.10E-92"
                     /label="couN4_AMP-binding.1"
                     /locus_tag="couN4"
                     /protein_end="401"
                     /protein_start="12"
                     /score="302.7"
                     /specificity="substrate consensus: Pro"
                     /tool="antismash"
                     /translation="ASAARTPDAPAVVGPAGSMSYGELDERADALAGRLSGQGISKGDR
                     VLIWSPKSANAIAAMQAVLRLGAIYIPVDPLTPPERFLVIARESGALALCAPEDLSARV
                     PSPLRDCLACVDLDAAPVPDALPRTPVSTCVEPDDLAYILYTSGSTGTPKGVCISHRSA
                     LAFIDWAVAELAPGPQDRFANHSGLSFDLSVLDLYAAFTVGAAVCLIQPEFAYVPEGLV
                     EFLHRERISVWYSVPSALILMLRDGGLLDRPAPGTLRALLFAGEPFPIGPLRALAAWSD
                     ARLLNLYGPTETNVCTYHEVRPADLARDLPVPIGKPCSGDRVWAIRADGSEAEPGEEGE
                     LVVSGPTVFAGYWGRQPQEGPYATGDRVKVRPDGSFDYLGRRDGMVKIR"
     CDS_motif       16349..16387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0001"
                     /evalue="1.20E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="couN4"
                     /protein_end="86"
                     /protein_start="73"
                     /score="9.4"
                     /tool="antismash"
                     /translation="AVLRLGAIYIPVD"
     CDS_motif       16499..16534
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0002"
                     /evalue="3.20E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="couN4"
                     /protein_end="135"
                     /protein_start="123"
                     /score="-0.9"
                     /tool="antismash"
                     /translation="LACVDLDAAPVP"
     CDS_motif       16586..16645
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0003"
                     /evalue="8.90E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="couN4"
                     /protein_end="172"
                     /protein_start="152"
                     /score="33.5"
                     /tool="antismash"
                     /translation="AYILYTSGSTGTPKGVCISH"
     CDS_motif       16760..16819
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0004"
                     /evalue="9.00E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="couN4"
                     /protein_end="230"
                     /protein_start="210"
                     /score="-2.2"
                     /tool="antismash"
                     /translation="AAFTVGAAVCLIQPEFAYVP"
     CDS_motif       17168..17233
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0005"
                     /evalue="5.70E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="couN4"
                     /protein_end="368"
                     /protein_start="346"
                     /score="21.9"
                     /tool="antismash"
                     /translation="PGEEGELVVSGPTVFAGYWGRQ"
     CDS_motif       17297..17359
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0006"
                     /evalue="4.50E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="couN4"
                     /protein_end="410"
                     /protein_start="389"
                     /score="31.6"
                     /tool="antismash"
                     /translation="YLGRRDGMVKIRGHRIELGDV"
     gene            17639..17908
                     /gene="couN5"
                     /note="proC"
     CDS             17639..17908
                     /NRPS_PKS="Domain: PP-binding (18-82). E-value: 2e-10.
                     Score: 33.1. Matches aSDomain:
                     nrpspksdomains_couN5_PP-binding.1"
                     /codon_start=1
                     /gene="couN5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to Pseudomonas fluorescens Pf-5 PltL"
                     /product="CouN5"
                     /protein_id="AAG29790.1"
                     /sec_met_domain="PP-binding (E-value: 1.1e-10, bitscore:
                     33.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTREDISSQLLTFIRESFLAGDPEGELDADTPLLELGILNSL
                     NTAILVAHLGEDYGVHVPLIDVTATTFKSVRTLSELVHESLSRK"
     aSDomain        17693..17884
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couN5_PP-binding.1"
                     /evalue="2.00E-10"
                     /label="couN5_PP-binding.1"
                     /locus_tag="couN5"
                     /protein_end="82"
                     /protein_start="18"
                     /score="33.1"
                     /tool="antismash"
                     /translation="ESFLAGDPEGELDADTPLLELGILNSLNTAILVAHLGEDYGVHVP
                     LIDVTATTFKSVRTLSELV"
     gene            17966..19648
                     /gene="couN6"
                     /note="cumK"
     CDS             17966..19648
                     /codon_start=1
                     /gene="couN6"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="other"
                     /note="CouN6"
                     /product="hypothetical protein"
                     /protein_id="AAG29791.2"
                     /transl_table=11
                     /translation="MFLLHAPSVYDFRDRDDILFAYLSDSDSVNVTSVYEMYPIGWFSI
                     KQQLADHDFDCQIVNIASLMLTHPNLDVERLIGRLEAPVFGFDLHWMTQCNGAIELAKA
                     VKRIHPESLIVFGGISATYFARELIRYPQVDVVVQGYDTLAPITQLVEAVVRGGRDFSS
                     IPNLLYKGNDRVETTGFSHKPTSDYNNVRNDWSYYQNTPVTPLSSKLIMTLPNTGCAHD
                     CGWCGGSRFAYRNIMEVDRTLVQKDHDLIVEELKTMGEAARHTSIYALQCYSEGKTRMH
                     AYLDAVRDLGYRSVFFEQFNLTPDDTLKKMGTSTDSYIMLSPESHDPKISKAAGRGTYT
                     MAEMEEWIPRALDAGVKGVMIWFFIGMPYQDKQSVRDTVAYSERLISKFAGSSVLPLIC
                     PMVPFLDPGCRFFEEPEKHGYRIHHRTLEQHRQAMVEPLWYRRLNYETEWLSRREIQDV
                     SYEAIERLVSIKGEHGVLSSVFCDAVLKTIDQTKRLLAEMDHALSLDGRLPATLRDEMR
                     AYNRKILAYSSDQILPIPRPFGGRWFDDVTVPEEMIRELSMTP"
     gene            19697..20542
                     /gene="couN7"
                     /note="cumL"
     CDS             19697..20542
                     /NRPS_PKS="Domain: Abhydrolase_1 (26-144). E-value:
                     1.2e-18. Score: 59.6. Matches aSDomain:
                     nrpspksdomains_couN7_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="couN7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN7"
                     /product="putative hydrolase"
                     /protein_id="AAG29792.1"
                     /sec_met_domain="PF00561 (E-value: 2.7e-19, bitscore: 60.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3e-13, bitscore:
                     41.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANHGPVVYGLEVPGARLHYEIQGAGPLLVVVGLPMGCKGFAPIS
                     RPLAEHFTVVTFDPRGVHSSPADDPNQDALPEVMADDVHRLISALDAGPAYLFASSGGG
                     VTALALAAQHPDQVRTLVAHEPPLLELLTDRVELRAAIDEICDMYRENRPAALQKYLAL
                     ADIRLHRPTPDPPGPNAFTAPWDVWTILDRLFRFTLRPTTRYRPDIDALRPMADRIVIA
                     GGSKAQGSLFHRTAVALADQLGTELVDFPGDHTGFLTDSEPFARLLFEVFTKARSHNGP
                     "
     aSDomain        19775..20128
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couN7_Abhydrolase_1.1"
                     /evalue="1.20E-18"
                     /label="couN7_Abhydrolase_1.1"
                     /locus_tag="couN7"
                     /protein_end="144"
                     /protein_start="26"
                     /score="59.6"
                     /tool="antismash"
                     /translation="PLLVVVGLPMGCKGFAPISRPLAEHFTVVTFDPRGVHSSPADDPN
                     QDALPEVMADDVHRLISALDAGPAYLFASSGGGVTALALAAQHPDQVRTLVAHEPPLLE
                     LLTDRVELRAAIDE"
     misc_feature    19796..19798
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20892..21584
                     /gene="couO"
                     /note="cumM"
     CDS             20892..21584
                     /codon_start=1
                     /gene="couO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /note="CouO"
                     /product="putative methyltransferase"
                     /protein_id="AAG29793.1"
                     /transl_table=11
                     /translation="MKIEPITGSEAEAFHRMGSRAFERYNEFVDLLVGAGIADGQTVVD
                     LCCGSGELEIILTSRFPSLNLVGVDLSEDMVRIARDYAAEQGKELEFRHGDAQSPAGME
                     DLLGKADLVVSRHAFHRLTRLPAGFDTMLRLVKPGGAILNVSFLHLSDFDEPGFRTWVR
                     FLKERPWDAEMQVAWALAHYYAPRLQDYRDALAQAADETPVSEQRIWVDDQGYGVATVK
                     CFARRAAA"
     gene            21984..22814
                     /gene="couP"
                     /note="cumN"
     CDS             21984..22814
                     /codon_start=1
                     /gene="couP"
                     /note="CouP"
                     /product="O-methyltransferase"
                     /protein_id="AAG29794.1"
                     /transl_table=11
                     /translation="MEVAPIVSRVAHKLRSQPEETTQGTGSDSSLYLDLMIKVLAGTVY
                     EDPAHRENFSHRDSTYREEVRSEGRDWPANAHTMIGIKRLENIRQCVEDVIGNNVPGDL
                     VETGVWRGGACIFMRGILRAHDVRDRTVWVADSFQGIPDVGEDGHAGDRKMALHRRNAV
                     LAVSEDEVRRNFRNYDLLDEQVRFLPGWFKDTLPTAPIDALAVLRMDGDLYESTWDTLT
                     NLYPKVSVGGYVIVDDYLMCPPCKDAVDEYRARFGIADELIRIDRDGVYWQRTE"
     misc_feature    22101..22103
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22911..24335
                     /gene="couR1"
                     /note="cumO"
     CDS             22911..24335
                     /codon_start=1
                     /gene="couR1"
                     /note="CouR1"
                     /product="hypothetical protein"
                     /protein_id="AAG29795.1"
                     /transl_table=11
                     /translation="MCTHSEHRSVQGSAATGVLHRVPNSLSFYYQHLLVASERIDTTWA
                     STDSWFEPSWQLPKLGPELDEFFSVSGISAGELGEYRGRRLHFLDLTENPGTHTTKTFG
                     SSVIVARAVRHTELTGEPVLLVTPSAANKAVALRNAVLRAYQVGLSDPSKLRVVTVVPS
                     SSLPKLWASDIDADPALRAANPMGVYSGPEREHVKEITTAAVGDLAADDPVLRGFRVWY
                     TLNPKNYMVADFIRTLFEYEYFPPVGERWHTHAVSSAYGFLGHDLGRQMAAEDGVRFDV
                     PQRYLLVQHLETPDLVSAVTGIDVETVVRDLYRATGDGLLTRPADADPRLPEYCYSTGE
                     RLERTFYTRNPPTTKAVRQLVADHGGNGIVVSLPECVNRYAFVRDLLRGADFHRLPEDP
                     RRLREWAMVMSAVGCLNAIDRDLIPAGADVVIHGSGAYSEGEFHQIDRSRLIEVNTPDE
                     VRALISGAIQADGERG"
     cand_cluster    23882..40210
                     /candidate_cluster_number="4"
                     /contig_edge="True"
                     /detection_rules="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /kind="single"
                     /product="aminocoumarin"
                     /protoclusters="3"
                     /tool="antismash"
     protocluster    23882..40210
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[33881:34772](+)"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      33882..34772
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="3"
     gene            24335..24853
                     /gene="couR2a"
                     /note="couR2; cumP"
     CDS             24335..24853
                     /codon_start=1
                     /gene="couR2a"
                     /note="CouR2a; similar to phosphonopyruvate decarboxylases"
                     /product="decarboxylase subunit"
                     /protein_id="AEO99210.1"
                     /transl_table=11
                     /translation="MSTAVVKPAEDVAGRLARILTTGRSGPFLGTPCGVLAQLYREIDA
                     ACGMRTIAREDSAVGVAAGAALAGRQPVVLMQNSGFGQSVNAFASLIMPCRLDVVTVIS
                     VRGMAPDNTEENSAMGTLTPTILAGLNADVRWLADGADLTEATANWLATEVDEPRFLLI
                     APGLFGWRP"
     gene            24850..25467
                     /gene="couR2b"
                     /note="couR2; cumP"
     CDS             24850..25467
                     /codon_start=1
                     /gene="couR2b"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic-additional"
                     /note="CouR2b; similar to phosphonopyruvate decarboxylase"
                     /product="decarboxylase subunit"
                     /protein_id="AEO99211.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.1e-16, bitscore:
                     49.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIRTMTHSPQNKAAAIAEIIGASGDTPIVFTTGYACRIANDIQD
                     KPGHFYMLGSMGLAGCVAVGVAAGLSRPVIVVDGDGSLAMNPGVLLLAAEFTGLPLIHV
                     VLDDRAYSSTGAQPTPPVGNIESWAASLGYLVLSPPLAGGVGSVVAGLLAGELTRPHLL
                     RLPVAPDGRNVPGRIEGRLSGYAARFRTHCRGLRAGSELPVV"
     gene            25500..26408
                     /gene="couR3"
                     /note="cumQ"
     CDS             25500..26408
                     /codon_start=1
                     /gene="couR3"
                     /note="similar to Salmonella enterica serovar Typhimurium
                     PduX"
                     /product="CouR3"
                     /protein_id="AAG29797.1"
                     /transl_table=11
                     /translation="MQPVESGRGRAVGTCGELVQGTVDGRELMVTFPVDWYSDVVVRGS
                     YLPGVRVWPRSKVKVRRMCDVLLDRLVGASSADVGLDVLVSSMIPEGRGHASSSADLTA
                     LCRAMAQWLGVPLADDDIMRLCCELEPSDAVCRPVPTLFDFIRGEVLLCYDDPPPMAAL
                     VLDEGGAVDTVTMRRLPCTEAESERLALAFDLVDRGFRLGDLALIGRAAMISAEVNQRR
                     VYKRNFEVARDVADACGSYGVSVAHSGTTLALLFDQHEVEGIRAAHAALRTVAADCELF
                     LLNAVVPTRRAAPDLTELPTR"
     gene            26463..27632
                     /gene="couR4"
                     /note="cumR"
     CDS             26463..27632
                     /codon_start=1
                     /gene="couR4"
                     /note="CouR4; similar to lactate and L(+)-mandelate
                     dehydrogenases"
                     /product="dehydrogenase"
                     /protein_id="AAG29798.1"
                     /transl_table=11
                     /translation="MGAIRFALPKQGRPISIAGYRTAARRVLPDLVWAYVENGADDSVT
                     LAANRSAFARWSLRQRVLRSSAGRKTAARFGDTELAIPVMIAPTGINGLVHWRGELATA
                     CGAAAAGSRIVLSTAASYSVEEVAAASPVGHWLQVYPWRDRELMDWLLERGRRSDCPTL
                     VVTVDTPVFGNREPERLQGMSIPPVLTPRHVLDAALHPRWAYKVLRHQRVFTGNLVGMS
                     GVRAGALAAKVRRERMMAGELDWDDFARVRAQWQGLCYVKGILDADDAERAVSLGADGI
                     IVSNHGGRQLDGAPATLDALPGIADRLAHRATVLIDGGIRRGTDVVKALCLGADGCLIG
                     RPALYGLAVGGESGVEHVLSILREEIDRTLALMGCSDIADLGRDWLIPG"
     gene            complement(27686..29161)
                     /gene="couR5"
                     /note="cumS"
     CDS             complement(27686..29161)
                     /codon_start=1
                     /gene="couR5"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /note="CouR5; transporter"
                     /product="putative resistance protein"
                     /protein_id="AAG29799.1"
                     /transl_table=11
                     /translation="MTETDVAEPVQAGRWAAYSVCLLAGFVTLLDVSVINVAVPSMQAG
                     LHLSAGQVLWAAFGYTLTFGVVLVPAGALGDQLGRRRTLLVGLAFFAFGSLACGLAASG
                     WWLVAARLVQGLAAGVVTPQVVGLMRQLFARGPELGKAGGAYSGMIAATTAIGPLVGGL
                     LIQAGGPADGWRWVFLVNVPIAALSLPLGLRWLPRDRQQIRGVRLDLLGIALLGSGVAT
                     LILPLIAAEQRQPSVPWHLLGLSALLLACFIAWQQHCTRSGRPRLVNLAMLRQRDYAIS
                     AFVGMGYFVGFVGIPFMVSLYFQLGLGYSALAAGAVGTPTALGAAISAPLAGRAVHRVG
                     RRLVVIGLAAVALGSAGLIALIGHRAGGLVWLLVAGPLLLAGAGSGLVIGPNLTLALQT
                     VPLTEGSAAGAVLQTGQRIGSTIGIAVIGALYFGSLTAHPGDHLRAATDGLLGSTVAIT
                     ITLLITVIALLATRDRRPSTQHGTPATDGDEPD"
     gene            29296..30171
                     /gene="couR6"
                     /note="cumT"
     CDS             29296..30171
                     /codon_start=1
                     /gene="couR6"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /note="CouR6"
                     /product="transcript regulatory protein"
                     /protein_id="AAG29800.2"
                     /transl_table=11
                     /translation="MVEVRQLRYFVAVAECEHFGRAAETLHIVQAAVSKQVARLERELG
                     LTLFDRSHRRVRLTPDGQAFLAHARRALRGLDRAAAAAADLAAGNTGLLRIGSSIGLGP
                     RVDAALAAVRSAYPGITLQVTTSASTTGHLAAVADYDLDAAFVAAPQATPGVQVHHLWD
                     EPLLLAVPAARAGSAGDLATLAELPLARYARADSPGTDDLITAACRAAGFTPRKGPTLT
                     RAQDLLTGPVSAGDCWAVLAADLLHHVPAAVALVPPVPPVLVPTALALPDPVRRAVVLN
                     LLTVAQAGTV"
     gene            30425..31291
                     /gene="couS"
                     /note="cumU"
     CDS             30425..31291
                     /NRPS_PKS="Domain: NAD_binding_4 (54-156). E-value:
                     6.3e-10. Score: 30.5. Matches aSDomain:
                     nrpspksdomains_couS_NAD_binding_4.1"
                     /codon_start=1
                     /gene="couS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /note="CouS"
                     /product="dTDP-4-keto-6-deoxyhexose reductase"
                     /protein_id="AAG29801.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.4e-106,
                     bitscore: 346.0, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNRWLVTGAGGMLGRDLVRVLEALNEPVLAATRQDLDITDRFSV
                     RAVVSRYRPTAIVNCAAWTRFHEAETSEAEAHLINGRGARELATICGDRSIRLVHLSTD
                     YVFDGASRRPYAESAATGPINAYGRTKLAGEQAVLELLPDDGTIVRTAWLYGRHGTNFL
                     RKMVRLEQTHKTVDVVDDQWGQPTWSVDLAQQIVALVRHGASGVFHGTSSGETTWYDFA
                     RMIFRLLGADPGRIRPVRSDQIAGGELRPRYTVLGHAAWREVGLTPIRHWSAALERSFP
                     LLADEEW"
     aSDomain        30587..30892
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couS_NAD_binding_4.1"
                     /evalue="6.30E-10"
                     /label="couS_NAD_binding_4.1"
                     /locus_tag="couS"
                     /protein_end="156"
                     /protein_start="54"
                     /score="30.5"
                     /tool="antismash"
                     /translation="TAIVNCAAWTRFHEAETSEAEAHLINGRGARELATICGDRSIRLV
                     HLSTDYVFDGASRRPYAESAATGPINAYGRTKLAGEQAVLELLPDDGTIVRTAWLYG"
     gene            31325..32335
                     /gene="couT"
                     /note="cumV"
     CDS             31325..32335
                     /NRPS_PKS="Domain: NAD_binding_4 (4-180). E-value: 6.2e-17.
                     Score: 53.5. Matches aSDomain:
                     nrpspksdomains_couT_NAD_binding_4.1"
                     /codon_start=1
                     /gene="couT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /note="CouT"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="AAG29802.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6e-25, bitscore:
                     78.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.2e-19,
                     bitscore: 61.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.3e-17, bitscore:
                     53.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLVTGGAGFIGSEFVRATLRGVLPGSSGTQITVLDKLTYSGNE
                     LNLAPIADLETYRFVQGDICDRGLVDDVVAGHDAIVHFAAETHVDRSIEGAASFVRTNA
                     LGTQVLLEAASRHRLGRFVHISTDEVYGSISEGAWTEASPVAPNAPYAAAKAAGDLLAL
                     AWHRTRKLDVVVTRCTNNYGPYQYPEKLIPLFTTNLLDGQQVPVYGDGHNRRQWLHVSD
                     HCRAIQCVLLGGRPGEVYHIGGGTELTNLELTEHILEACGAGWDRVRHVPDRLGHDLRY
                     SLDTTKIRTELGYSPRVAFADGLAETVEWYRTHRGWWEPLKNPDKATGSPTDAGR"
     aSDomain        31337..31864
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couT_NAD_binding_4.1"
                     /evalue="6.20E-17"
                     /label="couT_NAD_binding_4.1"
                     /locus_tag="couT"
                     /protein_end="180"
                     /protein_start="4"
                     /score="53.5"
                     /tool="antismash"
                     /translation="VTGGAGFIGSEFVRATLRGVLPGSSGTQITVLDKLTYSGNELNLA
                     PIADLETYRFVQGDICDRGLVDDVVAGHDAIVHFAAETHVDRSIEGAASFVRTNALGTQ
                     VLLEAASRHRLGRFVHISTDEVYGSISEGAWTEASPVAPNAPYAAAKAAGDLLALAWHR
                     TRKLDVVVTRCTN"
     misc_feature    31385..31387
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            32561..33823
                     /gene="couU"
                     /note="cumW"
     CDS             32561..33823
                     /codon_start=1
                     /gene="couU"
                     /note="CouU"
                     /product="C-methyltransferase"
                     /protein_id="AAG29803.1"
                     /transl_table=11
                     /translation="MQDIVRPINECRVCGHNDWLDVVSFGSTPLAGNLLGTEDDPRDET
                     LFPLDVGVCRKCWLMTLRHVIEPNALFGHYRYVASDAGSIIQHMRQLVELCIRWVGLTD
                     RDLVVEFGSNTGAHLELFQQAGMRVVGVDPARNLADIANDRGVTTIPAGFTTEVGQEIT
                     TGHGPARLVFGRQCFAHIHDVHEVLDGVSALLAPDGLFFVEVPYLVELLANNQFDTIFH
                     EHLSYFSLGALCRLFEAHGLRVVDVHTVDVHGGSIVVFAAPATAGYEVRPAVAEMLAEE
                     RSQGIAEESTYQKFAERTERVRAQIRELVRSLVADGKTVAGYGAPTKGSALLTACGLGH
                     QEIRFCSDTTALKQGKLLPGSRVPIWSPEQASDHVPDYYLLLAWNYASEIITKEKSFLE
                     GGGRFIVPIPEPRVISAESAW"
     gene            33882..34772
                     /gene="couV"
                     /note="cumX"
     CDS             33882..34772
                     /codon_start=1
                     /gene="couV"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: SpcDK_cou"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic"
                     /note="CouV; glucose-1-phosphate thymidylyltransferase"
                     /product="dTDP-glucose synthase"
                     /protein_id="AAG29804.1"
                     /sec_met_domain="SpcDK_cou (E-value: 1.7e-206, bitscore:
                     674.9, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.3e-14, bitscore:
                     43.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGILLAGGTGSRLWPVTRAVSKQLIPVFDKPMIYYPLTTLMMAG
                     IREILVITRPEDQRQFRHLLGDGSQLGLCLEYAVQEKPEGIAQAFVLGADFIGDQSVAL
                     VLGDNIFHGAGLGTRLRQYSDPAGGRIFAYVVADPRAYAVVEFDEAGTAVSIEEKPASP
                     KSRYAVPGLYFYDNRVLEVARDLMPSQRGELEITAVNETYLKWGQLRVTTLDRGAAWLD
                     TGTFTSLVQASEYVRVVEERQGLKIGCVEEVAWRCGLIGNDQLRELSRPLLKSGYGRYL
                     LDLLADQELKELKSS"
     gene            34769..35365
                     /gene="couW"
                     /note="cumY"
     CDS             34769..35365
                     /codon_start=1
                     /gene="couW"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /note="CouW"
                     /product="dTDP-4-keto-6-deoxyglucose 3,5-epimerase"
                     /protein_id="AAG29805.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 4.7e-62,
                     bitscore: 199.7, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLRPLGIEGAWEITPKQHADPRGVFLDWYRVDQFAAEVGRPLRL
                     AQANLSVSVRGVVRGVHFADVPPGQAKYVTCVRGALFDVVVDLRVGSPTYGRWEGTRLD
                     DVSRRAVYLSEGIGHGFCAISDEATLCYLSSQTYNPASEHGVHPLDPELAINWPVETPL
                     LSARDQDALLLAEARDWGLLPSYAACQALTALTSQ"
     gene            35917..37950
                     /gene="gyrB-Rc"
     CDS             35917..37950
                     /codon_start=1
                     /gene="gyrB-Rc"
                     /note="GyrB-Rc"
                     /product="DNA gyrase subunit B"
                     /protein_id="AAO47225.2"
                     /transl_table=11
                     /translation="MTTYDTRTATDTRGSEQPGHVGTASYDANAITVLDGLDAVRKRPG
                     MYIGSTGERGLHHLVQELVDNSVDEALAGVADRIDVTVLADGGVRVVDNGRGIPVGMHP
                     VEKRPAVEVVLTVLHAGGKFGGGGYAVSGGLHGVGLSVVNALSTRLSAEIWTDGHRWTQ
                     DYRDGAPTAPLARHEATSRTGTSLTFWADGDIFETTEYSFETLARRHQEMAFLNGGLTL
                     TLTDERSSARATAAVDEADSDPTAKTVSYRYDGGITDFVVHLNARKGEPAHPSVITIAA
                     EDTERLLSAEIALQWNGQYTDSVYSYANAIHTHEGGTHEEGFRTALTTVVNRYAREKRL
                     LRDKDANLSGEDIREGLTAIISVKLGEPQFEGQTKTKLGNTEVRTFVQKIVHEHLADWF
                     DRNPNEAVDIVRKAVQAATARVAARKARDLTRRKGLLETAALPGKLSDCQSNDPATSEI
                     FIVEGDSAGGSAKAGRNPQYQAILPIRGKILNVEKARIDKVLQNQEIQALISAFGTGVH
                     EDFDIAKLRYHKIILMADADVDGQHISTLLLTFLFRFMRPLVEEGHVHLSRPPLYKIKW
                     SREHVEYAYSDRERNTLLERGRRDGRRIRDDSIQRFKGLGEMNAEELRVTTMDPDHRVL
                     GQVTLDDAAFADDLFSVLMGEDVEARRHFIQRNAQDVRFLDI"
     gene            38029..40140
                     /gene="parYR"
     CDS             38029..40140
                     /codon_start=1
                     /gene="parYR"
                     /note="ParYR"
                     /product="DNA gyrase subunit B"
                     /protein_id="AAO47226.2"
                     /transl_table=11
                     /translation="MSTFPAPAAGSRPQDGSDYTARHLMVLDGLEAVRKRPGMYIGSSD
                     SRGLMHCLWEIIDNSVDEALAGACDHIEVILHDDGSVEVTDNGRGIPVDTEPRTGLSGV
                     ELAYTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDIEVDRHGRTHAISFRRGAP
                     GTYSAPGPDAPFTRAQGLHRTARIPKSRTGTRVRYWADRQIFLKDAKLSLENLHQRARQ
                     TAFLVPGLTIVVRDEYGLGEGGSKGEESFRFDGGISEFCEYLAADKPVCDVLRLTGQGT
                     FKETVPVLDEHGQMTPTEVTRELGVDVALRWGTGYDTTLRSFVNIIATPKGGTHVAGFE
                     QAVAKTMNEVLRAKKLLRVAEDDIVKDDALEGLTAVVTVRLAEPQFEGQTKEVLGTSAA
                     RRIVNTVISRELKAFLTSTKRDAAAQARVVMEKAVAAARTRIAARQHKDAQRRKTALES
                     SSLPAKLADCRSDDVERSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQKSSVT
                     DMLKNAECGAIIQVIGAGSGRTFDIDAARYGKIIMMTDADVDGSHIRTLLLTLFHRYMR
                     PMVESGRVFAAVPPLHRIELVQPKKGQDRYVYTYSDRELRDRLMEFQSKGVRYKDSIQR
                     YKGLGEMDADQLAETTMDPRHRTLRRINLSDLEAAEQVFDLLMGNDVAPRKEFISSSAA
                     TLDRSRIDI"
ORIGIN
        1 ggtaccgggg gtggcggctg gtcgcggtgg acggaaccac cttcgacgtg ccggacaccg
       61 aggccaatgc cgccttcttc ggccgaccgg gagtcagccg cggacaggag aagagcgcct
      121 atccgcaggt gcggctcgca gcgctggccg agtgcggcac acacgcagtc ttcgcagccg
      181 aggccggacc gctggccgtc catgaaaccg agctggccca gcgcctgttc ggctcactga
      241 cgccagggat gctactgctg gccgaccggg gctttcgcgg cttcgacctg tggcgggcag
      301 ccgccgcaac cggcgccgac cttttgtggc gggtcaagaa cgacgccgta ctccccgtcc
      361 ggaccctgct ggaggacggc tcctacctct cggagatcgt cgcggcccgg gacaagaacc
      421 gtcgcgcgga cccggcccgg gtccgcgtga tcgagtacac cctcggccgc gacggcagcg
      481 acaccgtgta ccggctgatc accaccatcc tggacccgaa ggccgccccg gccgcgtcgc
      541 tggccgcgct ggcggcccag cgatgggaga tcgagagcac gctggatgag atcaagaccc
      601 atctcggagg tccccgcctc gtcctacgct ctcagcaccc ccgcggcgcc gagcaggaga
      661 tcttcgcctt cctgctggtg caccacgccc tgcgtgacct gatgcaccag gccgcacatc
      721 aatccgagca ggacccggac cggatctcct tcacccgcac cctgcgcgtc gtccgccgcc
      781 acgtcaccga ccaggcggca tttcccccct cccggctggc ccgggcactg gtcacggccc
      841 tgcatgagat ccgcgaacgg ctcttgtcac cccggcggtt gcgctccagc ccgcgcgtca
      901 tcaaacgcaa gatgtccaac tggaaactca aacgcgccga gcaccacaat ccgccccggc
      961 cggacactcc ctacgtgacc ctggtcgggg cgaccaaggc caggccgacc caccggaaaa
     1021 caacctaaat caccggtatt gcgtctaggg ttccgcccgc cctgggatga ctccgtgccc
     1081 ccgctgggcg ttgctccacc cggttgcgct ggaatacgcg tccagcaggt ccaccacgaa
     1141 gaccagggtc gagctcggcg ggatcaacgg cgaaggcgac tgattgccgt atccaagacg
     1201 cggaggaacg atgatctcgc gccgaccgcc gacgttcatc cctctcaccc ctcggtccca
     1261 gcccttgatg accttgccac tgcccacggc gaacttgaac ggctggcccc gatcccagga
     1321 ggcatcgaac tccttcccgg actcgaaagt caccccgaca tagtggaccc tgaccaccat
     1381 gcccggcttg acctcgaccc cgtcaccgac gatcaggtcc cggatggtca gctcggtagg
     1441 cgcgtcgccc tctggaacgt cgacctcggg ctttgtcggt tcactcatca cagcctcatc
     1501 acttccgtcg gaagccgtcg gaccagccgg acacatggac actccgtgca gcagatggtc
     1561 aggctatcga gagcgcccgt ccgcgctctc acgcagacct acgcggagaa aaggaagacg
     1621 gtgccatccg ttgccgaggc ccgccgcgag ttcggcccac agacggttcg cgctgcccgg
     1681 tctgctccgc acggtccacg acccggcctg cggaacgggc ggactgctcg atgaggtggc
     1741 cgagcgcatc gagtccgtcg acgcccaggc ggggtgagag cgacgccggg tgggtggatt
     1801 tctcccaggg cttgcgctgg tcggtggcga gcggggcggc gaggcggagc tgggtgtgcg
     1861 cgatgatcac cagccaggtc cagcggtccg ccgcctctgg ttcacgcatg ctcccgtgct
     1921 cgttcgggtc aggcccaggc ccaggcgcgg ggcgcacgat gctttccacg tcttgatcga
     1981 tgaggcatgg cggggcaggc gctgaggggt ggacacggat atcgccgact gttatgagga
     2041 gattccgcat gaggagttga tgcaagcggt cgaggaacgc gtctgcgacc ggccggcatt
     2101 caaacctctg cgcgcaatgc tgtgggcagg ggtgacggag gacgggctgg tccggcgatg
     2161 gctgaactcg gcccgtcagc aggccgacgg ctcctcatga aggatcgaag tcagtaatct
     2221 gacgatcggt cggtcgaagc agcatgtctg agacgggccg aggctccgcc gacatgcttg
     2281 tcctgacgac ggaaacggga ggcatcgtgg ttgcgtctgg tcagacagct tcgaaggctg
     2341 gggggtccgg cgccactccg gtgagaccga ctgcagggga cgcgaccccc gttgacagca
     2401 ggaaatcaag ccacgcctct tgtcttggtg tggaggtttc ggccgagagg accaggcttc
     2461 agatcccgca agatctctcc ctggaggcat ggtgccgcct cggcggaagg atcctcacgg
     2521 tgtgcgattc gtcggcctgg tggatcggtg attggttggt gttcgggcag aaccagtatg
     2581 gtgaccgata ccgccgggcg atggagaaga ccaagctcga ctaccagacg ctgcgaaatt
     2641 acgcctgggt ggcgagaaaa ttcgagccgt cccgccggcg agacagactc acgttccaac
     2701 atcacatgga agtggcatct ctctcgcaag ccgaacagga tcactggctc gacttcgcgg
     2761 ttcgactgaa ctggtccagg aaccagctgc gcaaacagat ccgggccagc atatcgggcg
     2821 aagaagatga tctgcggcgc catgttcagc tcagccttca attagacgag ttacgtctcg
     2881 aacggtggag ggaggcggcg cgggggagca atctgactct gacggactgg atcttattcg
     2941 tcgtcgacga ggccatttga ccggatgcgc ccatgcgatg tcggtgcccg acgacactgc
     3001 tgcgtggcgg ccccgaaggg attgcgggag atcaatgcgc acggccgagg gaccgtcggg
     3061 agcggtggac ctggcggtgg tcgccgtgcc accgggccag gtgacaccgg tggtcgcgtc
     3121 tcaccggtca aggggagccg ctcgctcctc cgtcgacgtg gcgggagtga aggtctcgcg
     3181 ctggcgtgaa cgggaagtac tgggttgtga ccttgcccct gtggtgggtg gtcatccacg
     3241 ggtgggacgg ccgggagccg gttccctcac ggcgcaggat gacctgcgga aagcgacctg
     3301 acgggcctgt tggagacact cggagctgtc gcgggcggcg gcggctcgcc cgcggagtcc
     3361 gacggtcatc tgctgaagtt cgtccagcgt cgcatcgatg gctgcaaccg cgttcccggc
     3421 aggtacggga ttgccacgga gaccgcactc gcgggcatcg atgtttccgt cggcgaccgg
     3481 ccgacggagc cggcccgccc cgtcagcgac gtggccggcg ccggggtggg gatgcacggc
     3541 agcaacatct cgcagcggct gcacagcctc gacctcacgg tcaccatttc cgtcactccg
     3601 tgcaacgccg aggacctctt gcacgaacta cgtcgtagga agtggccggc ggacgcctga
     3661 catcggggag ggcggtcaac tcgaccgaac tcctcgaatc cggccttccg ttcaccatgc
     3721 ggcacgccct tctcggtgag cactcgcgca acaccggcgt cgccgggccg caccggcgcg
     3781 cgaagaactc gacatgcacg gcgccgatga cctccagggc gccgatgtcg gtggcttaga
     3841 atcgaagggg ggcagtcggg gatgggctca ccgtcaacca ctcacaggcc gcgccgggta
     3901 gagccgacga ttccgcacac cgtgcgaatg ttcatacgtc aggcgtggcc gtgatcgatc
     3961 tggacgcgga ccgaattgag ctattcgggc aatcgttgta acgagcgatg aacgtgattt
     4021 gatgctgctg agcctggcca agacctgcgt ctggtcaccc atgtcctaca cgcgctgatc
     4081 caagccagat cattatgtcc tagggggggt catatgagta acagcggtga tgaggagatg
     4141 acgtcgattc tacctaaagc aatcggaaaa ggggaacggg ttccgatcgg ttcgttgttt
     4201 ccgtcgcaac aactactgcg gtccggtgaa agtacggaac acattcgtgc actggtcgaa
     4261 acggaagagg tcctgccgcc gattgtcgtg caccgtgaga cacggcgggt catcgacgga
     4321 atgcacagac tgcgggcagc tcgttttcgt ggcgacgaat ggatcgaggt cgttttcatc
     4381 gatgacgcct cagccgatgt gtttgtcctc gcggttgagt tgaatcgtgc gcacggcctg
     4441 ccgttgacga tggctgagcg caaatctgcc gccgcgcgga tcatggattc gcacccgcac
     4501 tggtccgacc gcaagatcgc acgtaccact ggactggcgg ccagcactgt cgcgtctctg
     4561 agatcgcact ccatcgctgg cacgctcgag cgtagaaccg ggcaggatgg ccggactcgg
     4621 cccaaggacg gcacggaagg acgccggcgt gcgagcgagc tgctggccca gaacccgaac
     4681 gcgtcggttc gcgaagtagc caaagcggcg cggatctcgg tgggcaccgc cagcaatgtg
     4741 cgcgcgagac tgcggcgagg cgagccggcc ataaccgccc tgcagcaggc agccctgaca
     4801 ccacgcccgg cctcggcgac gcagcgaacc ggtccggact acagccgcgt gctgcagagc
     4861 ctgcgcaaca acccatcgct gcggttcaac gacgtcggcc gacacttgct ccgcttgctt
     4921 ggcggcgccg ccccgggcag cgtcgagcag attgcccaga tcgcggacag tgtgccggaa
     4981 cactgtcggg tcatggtgat cgacatggcc cgcgagtgcg ccgccgcatg gcaacatctg
     5041 gccgaccggc tcgcgggccg agacaccgcc tgacggagac gtaccgtccg atccggccgc
     5101 tgcgggacgt tcaactgctc gaaccatacg gttgaacgcc accacacagt cgaacgtcga
     5161 cggtcggcat cctggtgacc aggccgggcc tggaatgttg aaccgccccg gtgcgatgaa
     5221 gacgatggag agatggctcg gtctccgagg cactctcgtg aggtacgtga acgtgccgtg
     5281 gcggtggtgt tcgagaaggc agatgagtat tctccgcaac acgttttcga ggtcgcggca
     5341 gtccggtaca cctgcctgca ggaccgacag gtcggttctc cagcgatgag atctacggag
     5401 gcgcatgtaa tggcgacgaa cccgttcgat gacgagaacg gcgtctatct gctcctggtc
     5461 aatgacgagg ggcagcattc tctgtggcct tcgttcgctg ctcttcccaa ggggtggacc
     5521 gtcattctcg atgaggcgtc gcggcaagag tgcctcgatt acgtcaacga gcattggacg
     5581 gacatgcgac cgttgagcct gcagccggcg atgggtgacg agtagaaacc gctcgtttca
     5641 gcgatcaaca acatcaagcc caccgacagc acccattcaa cctctgtggc tgtccaagat
     5701 gttcaaggag tcaggcgctt cacggcagac ccagggcgtg attccatcac gcgaggcgtt
     5761 cgatgcatga cttcccagcg cttggagtgt cgtcgagatt gatatcgagc aagctgtctc
     5821 ggaagtcacc tgttcgtgca gcatttcttt tcggctatct ggggagtatg ttccgatggc
     5881 atggagactt aacggcggta caacgatgct gatattcaac agggggcggt ttgttctcca
     5941 agggtctgaa caaggcttct gatcggtcgg cgacaacgag gacggcatcg gccacgctgg
     6001 ccgaactgtg ggagcggacg gtacgcagtc ggccaagcag tccggcgatt gtctcgaaca
     6061 gcgagaccct gtcctacgac gaggtgaacg ccagggcgaa ccagctggcc cgactgctgc
     6121 tcagcgaggg ggcgggcccg ggccgggtgg tggcactggc gctgccccga tccagtcgaa
     6181 tggtgatcag cgtgcttgcc gtggccaagg ccggggcggc gttcctgccg gtggacgtca
     6241 actacccgga gcagcggatc gcctacatgc tcgctgacgc cgagcccgca ttgctgtgca
     6301 ccatccggac cgcagtccct aagctgcctg ctgacatcgg ggtgccgcag ctggtgctgg
     6361 actcggccga gcagactgcc acgctcgacg cactgcccga caccgacgtg actgaggacg
     6421 aacggggtgg ttcactcgcc gcgaccaacc tggcttacgt gatttacacc tcgggctcga
     6481 caggtcggcc gaaaggtgtc gctctgaccg gtgccgggtt gcccgccttg gccgcggcca
     6541 aggtcgccac gatgcaggtc actgaggaca gtcgggtgct ccagttcgcc tcgccgagct
     6601 tcgacgccta tgtgaccgag ctgctggcca cttttacctc cggtgccact ttggtggtgc
     6661 cagggtcgga cacactggtc ggcgacccgc tggcaaaggt cctacgggag ggccaggtca
     6721 gccacgcggt gctgccgcct gccgcagtcg cgaccatgtc cccggacgcg gcgccggacc
     6781 tgcgcgtgct ggtggtggcc ggcgaggagt gcccggccgg cctggtggaa cagtggtcac
     6841 caggacgcct tttggtcaac gcctacggtc cgaccgagtg caccgtgtgc gcgaccatga
     6901 ccggcccgct gaccccgacg gacgaggtca ctattggccg gccgattcct ggcgtgtctg
     6961 tgcacatcct cgacgacgaa ctactaccgg tcgcggccgg agaaatcggc gagttgtacc
     7021 tcagcggtgc cgggcttgcg cgcggctacc tcaaccgccc tgatgtgacc gcgcatgtgt
     7081 tcgtggccaa tcccttcgcc gccgacggcg aacggatgta ccgcaccggt gatctggcct
     7141 ccatgcgggc cgacggcgac atcctgttcc acggccggat cgacgaccag gtcgaactgc
     7201 gcggattccg aatcgagctc ggagaggtgg agtccgtgct cagccaacat ccggacgtgg
     7261 cgcaggcggt ggccgtgctg cgggccggcg aagacgacgg gccgcagctg ctggcctacg
     7321 tggtgccgac gcacggcacc acgcccgcgg caggcgaact gcgtgagcac gccggccgct
     7381 acctgcccga ctacatggtg ccgtcggtct atgcgaccat cgacgccatt cctgtgactc
     7441 ccagcggaaa gacggaccga gccgcgctgc cgccgatcaa gaccaccagg cccgccggtc
     7501 agaaaccgcg cacttccgcc gagaagatcc ttttcgatat cttccgggac ctgttcggcc
     7561 ttggtgagat cgacgtgcgc agtaactttt tcgaaatggg cgggaacagc atcctggctg
     7621 tcgacctcat tcagcgagcg caggaagccg gcttggtgct cttgccgagg accgtgatcg
     7681 accacccgac catcgagcag ctggccgcga tagcgaacct cggggagtga gagatgagca
     7741 cccgtcccat ggtgtccgcc gacgaactcg aggacatcga cctggcgtcg cccattctgc
     7801 acgccgagta cgagctcgat gcggtcttcc gtcatctgcg ggccaatcgg ccgatgtact
     7861 ggcagcagcc acggggtgag cagcccggct tctgggtgat cagccggtat gccgacgtga
     7921 acgaggtgta caaggacaag gcgcacttca ccacggagaa cggtaacgcg ctggccacct
     7981 tgctcaccgg cggtgactcg gcctcgggtg ccatgctcgc ggtcaccgac ggtgtgcgcc
     8041 accaccaggt gcgcaacctg ttgtccaagg gcttttcgcc gcagatgctc gaactgatcg
     8101 ccaactcgct gcgggaaacc gttgacgggc tgctgctggc cgcgctggat cgaggcgaat
     8161 gcgatgccgc acgggacatt tcggcgaaag tgccgctggg cgccatctgt gacctgttgg
     8221 aaattcccca gaccgaccgg gaatacttgc tcggcttgac cgcgcacgcg tggagcacgg
     8281 actacgcgga cgaacctcct gaggagagct gggtcgccaa gaacgagatc ctcctgtatt
     8341 tcagtaaact gctcaaggag cgtcgtggtg gtgaccggga cgacatggtc agcctgttgg
     8401 cgaattgccg gatcgacggc catccgctca atgcggccga gcagatagcc aactgctacg
     8461 ggctgatgat cggcggcgac gagaccggca gacacgccat caccggcacg gtcctcgcgt
     8521 tgatcgagaa tcccgaccaa tggcgagccc tgaagaatgg cgatgtcgat ctgaagacgg
     8581 cgaccgagga ggcactgcgg tggaccgtgc cctcgctgca cggtggccgg aaggcaaccg
     8641 gagacgttgt gatcaacggc cagcagatca aggccggcga ggtggtcagc gtgtggatct
     8701 cctcagccaa ccgggatgag accgtcttcg acgcggcgga cgagttcaag ctcgcccgca
     8761 ccccgaacaa gcacttcacc ttcgcctacg gctcgcacta ctgcctcggc cactacctcg
     8821 gccggatgga ggtctacgcc gtgctcgacg gattacgccg gctggtgggc gacctggagc
     8881 agatcggcga agagcggtgg atctactcca gcatcctgca cggcatgagc tcactgccca
     8941 tcaagatcac ggcctgaagc cccccggggg acgtgcacat gatgagcacc gtcaacgcgg
     9001 ccaacgcatt cgaggacggg ccaggcgccg agttctcctc ggatcgcccg acagcccgcc
     9061 cttgcgtaca tcgagcggaa tggggcggcg cgccgaccgc ggagcgcgac ccggtgatga
     9121 ctgggcccgc cgcatcagcg gtggcttgcg agccggtcgc gatggtcacc ggagccggcc
     9181 ggggcatcgg cgctgccacg gccgagcgcc ttgccgcgga gggcatggcg gtgatcgtcg
     9241 tggaccgcgt ggaacaggac accacagcca ccgtctcggc catccgtgcg gccggcggac
     9301 gggccagcgg gctcggctgt gacgtctccg tagctcaggc ggtgacggcc accgtcgcct
     9361 cggccgtcga ggagttcggt cacctcgacg tgctggtgaa ctgcgccggg atcacccagg
     9421 atcggctgct gctcaccatg agcgaccagg agtgggacag ggtcctggac gtcaacctcg
     9481 gcggcagcat gcgatgttcg ttcgcggtcg ggaggcacat gcgccggcag gggcacggcc
     9541 ggatcatcaa cttcagttct gttgccgcgc gcggcaatgc cggtcagacc aactatgcga
     9601 ccgcgaaggg cgcgattgcc gggttcaccc gcacgctcgc ggccgaattc ggtccgcacg
     9661 gcgtgacggt caactcgatc gcaccgggct tcgtggccac gccgatggtg gcagagctga
     9721 ccgaacggct cggcgtggat cgggacaccg tcctgctgga ggcggcgatg tcctcggccg
     9781 tgggccggat cgggacgccc gaggaaatcg ccgcggtggt ggcattcgtc acccggccgg
     9841 aatcgggcta cctcaccggg gagaccatcc acgtcgaagg tggtcggcga tgacgggagt
     9901 cgcggtcgtg gccggcggcg gcgagcacac ggggcccgcg gtcgcggtca ggttggcggg
     9961 gcggggcttc gatgtcgccc tgctggacac cgagttcacg gcggccgaca aaactgtcag
    10021 gcagatcgag gagtccggca ggcggtgcgt cacggtggag gccgagttga ccgacaccag
    10081 gtcggtcggt gccgctttcg gccaggtgcg tagcgcgctg agcagccccg tcgtgctggt
    10141 cacctgcgtc ggaccggggc cggtgccgga cgggtcaccc gaggacgaac tcgcggacga
    10201 acagcgctat ggcgtggtcc gacgggcgct gcgctcggcg ttcgtatgtt gccaggccgg
    10261 ggccggccac ctactgcatc accggtgggg acggatcatc atcgtcaccg agccggtcga
    10321 cgcgggcgga aacgcctggc gcacctccca gcccgtgctg gccgggttga tcggtttcac
    10381 ccggtccgcg gcgctggagc tggcgaggtc cggtatcacc gtgaacctca tcgcgccggc
    10441 cgagagcgcg gtcgacagcc gggccccggc gcaccaaccg gcggtcaacg tcggcgcggg
    10501 ctcctacgcg gagggggtcg cgcacgtgac ggcgtttctg atcgacgatc aggccgtcgg
    10561 aatcaccggg caggagatat acctcgccgc tgcccaagcg ggagtgcctc tacttcgcga
    10621 aaggtagtca ctggtggcga acagggacca cgggccggag cactacgtca cccgcatcct
    10681 cgatgaggcg gcccgggacg gcgcgcgacc ggttgtccgg tggcgggaca cggtaatcac
    10741 cggcacagag ctccaccggt cggtacggcg ggtcgcgacg gcactgcgcg aggcaggtgt
    10801 ggcacgcgac cacgcggtgg ccatcctgac ccaggtgaac agcccatgga tgctggtcgt
    10861 ccgctatgcc gcacacctgc tgggcgcatc ggtcgtgtac ataaccggcg ccaaccacgg
    10921 caccgtgacc cacgacctgc cggtcaccac ccgggtccgg atgatgcgtg aagcaggcgc
    10981 atctgtactg gtgttcgatg agcgcaacgc tcagctcgcc gagaccatcc gcgagacggt
    11041 tccggacaaa ctcgtgctgt gcggcctcgg ccatccggcg tccggcacgg tgaccgccga
    11101 cggccggccg gtcgaggacg tggcggtgga attcccggcc gagacacctg agctggcaat
    11161 ggtgctctat accagcggta ccaccggtca acccaagggg gtgtgcaaac cgttcggggc
    11221 gtggaacgcg accgtggtcg gcctggccgg gcaaccccgg ccgcggcaga cctatctggc
    11281 gatgaccgcc gtgagccaca cagtgggaat ggtcgtcgac atagcgctgg ccgccggcgg
    11341 cagcgtgctg ctgcgtgaga agttcgatcc caccgacttc ctgcgagatg tcgtgacgca
    11401 cagggtcacc gacacgttca tgggtgtgcc gcagctctac gcgatcctca atcatcccga
    11461 tgttcgcacc acggacctgt cctcgctgca acacctggtg tacgtcggct gtcccgcatc
    11521 gccggaacgc ctgcgggagg cggtcactgt gtttcccggt gtgctgtggc agtcctacgg
    11581 ttccaccgag accggccgga tcgcgatgct ccgtgaggac gaccacgacc atcctgaact
    11641 gctggccacc gtgggccggc cgatgccggg ggtcaccatc gcgatccgcg acccgcaaac
    11701 aggacgagac ctgccggtca acgagatcgg cgaggtggtg gtgcacagcc cgaacaacat
    11761 ggccggctac atcggcgatc ccgagggcac cacgcgggtg gtccgagacg gctgggtgca
    11821 taccggcgac atgggctccg tcgacgaacg cgggtacgtg cggctgttcg gccggatgca
    11881 cgagatggtc aaagtgcagg acacgcgagt cagtccgacc gaggtggaga aggtgctcgt
    11941 cggctgtccc ggcgtggtgg atgcgtgcgt gtacggccac cgcaggccgg acctgatcga
    12001 ggaactgcac gccgccgtcg tgctcagtac cgaggacgcc ccgagtttcg ccgctctgcg
    12061 cgaccacgtc gcgcagacca tgaccccgac gcacgctccg gtccggttcg tgcgctggcg
    12121 gcagttcccg atcaacaaca ccgggaagac ggatcggctg cggatccgcg aggtcagcgc
    12181 cgaggctcgc ggtgagggcc cggacgtgct ggtggacagg tgaggtgagt cattcgatga
    12241 gagtgctgtt cacgagcctg cccggtatcg gccacctgtt tcccatggtg ccgctcgcct
    12301 gggcgctgca ggcagcaggg cacaccgtgc tggtcgccac cgaccgtgag ttcctcccgg
    12361 tggtgaccgg agccggactg cctgccgcgg ccgtgcggga ccctgttgac ccggtcgagc
    12421 tgttcaaacc ggtcagcctg tccggcctgt ccggcctgct cggcttgtcc ggcggtccgg
    12481 tgagcccggc tgagaggacc ggccaccggt gtgccgagat cggtgtccga gcgctggccg
    12541 ccgtccgtgc actcgtcgac gcatggcgcc cggacctggt gattgccgaa cccatggagc
    12601 tggccgggcc tgccgcggcg acgatcgcgg gcgtgccctg ggtgcggcac tcctacggcc
    12661 tgatcccacc ggagcgactg ctgagcgccg cggccgcggc cctggactca gaactggcgg
    12721 tacgcgggct gtccccgtgg gcagagccgg ccggcacgat cgacgtgtgc cccgacagcc
    12781 tccagccttc ggatgcggtg gcgaccatgc ccatgcccat gcggtatgtg ccctacaacg
    12841 gcccggccgt cgtgcccgac tggctactgg ccgggccgtc gccacggccc cgggtatgcc
    12901 tgaccttggg cacgtccctg cctcggcgca atccgcgggt cgcaccgctg tggcggctgc
    12961 tgctggacga actggtggcg ctgggccaag aggtggtcat cgccatcgac gagagccacc
    13021 ggtcgctgct gggtcacttg cctggcggcg tgcgtgcggc gaggatcccg ctgtgtgacc
    13081 tgctgccgac ctgcaccgcg atcgtgcatc acggtggctc cgggagcacc atggcggcgg
    13141 cggcgttcgg cgtgccgcaa ctggtcgtcc cgcacttcgc cgaccacttc gccaatgcgg
    13201 agcggatcat cgcggtcggc gcgggcacga gcctgccgca cgacaccgat gacctggcgc
    13261 ggatcacagc agcctgcgcg ctgatcgtcg atgacggccc gcaccgggcg atctcagcac
    13321 gactcgccga agagaacgcg agccgaccga aaccgaccga ggtggcccag gacctggtgg
    13381 ccctggtcct cgagcacagc caggatgtcc tgcgaccgca gcacgcgtcg cagggtcgac
    13441 agtaggcagg actgctgcgg atgtcgtgct ggcactgtct tgcgactctt ctccgcggca
    13501 acacaatcga cgggaactac gcgacatggt cactggacgc accgagctcg agcacgtcct
    13561 tactcgcctg gaaatgctgc tgaacgacgt ctgggaccag cggccggcgg gggtggcgat
    13621 gtctgccacc gcaccgctgg tgagcctcgg ggtggactcg ctcacgctcg cgctgctcct
    13681 cgacaacgtg ggcagggaat tccacatcga ctggacggcc gatacccgtc tgggcggagc
    13741 gatctcgcta cgttccctcg cggatctcgt cctgcgacgg gacggcggcc ccgccgccgc
    13801 tgccgaggca tagggcccgg cccatgcgga catcgggtac gtacctggcc gggatcggag
    13861 tcttccggcc caagacgaaa agcgtcgatg ccgcggtgcg gcaggggctc gtctcgaagg
    13921 aatctgctga cgcctccgga atcaccggcg tgtccgtcgc cggtgacgtc tctcctgccg
    13981 agatcgcgtt gatcgccgca cgccaagccc tccacagcag tggactgagc gccgatgaca
    14041 tcggactgct gctccacacc ggggtttggc accagggacc cgacggatgg gggccgcagt
    14101 actatctcca gcggcacctg ctcggtgacg atctgctcgc cgtggaactc aggcatggct
    14161 gcaacgggac tttcagcgca ctggagttgg ccgtccccta cgtgaaatgc gcacctcatg
    14221 ccggcggggt gctgatcacc gccagtgaca actttggcac cccgctgatc gacagatgga
    14281 accccggcga agggatggcc tacctgggtg acggcgcggg cgcggtggtg ctgggctctt
    14341 ccccggggtt cgcggagctg ttgtccatat gcaccaccac gttctccggg atggaggagg
    14401 tccaccgggc cggtgagccg ctctttccgc ccggcgccac caccggtact tttctggact
    14461 acggtgccag agccgcgcga ttccagcaga gggcgaccga tgacggcacg tgggtgcagc
    14521 tcctcctggg ccaccagaag cacaacgtgg agtgcgtggg ccaggcgctc cacgaggccg
    14581 gtgtcgacgc ccgcgacatc aagaccgtcc tgatccacag catgccgcgt caggcggccg
    14641 cctcctacct gaagatcctc ggtttctcgc tggaccgctc gacctgggag ttcagccgga
    14701 caaccggcca cctcggggcc ggcgaccatc tcgccgctct ctaccacctg ttgtcgacgg
    14761 gcgaggtcgg ccccggcgac aacctgctgc tgtgcggttc ctcgcctggc gtcacgtaca
    14821 aggcggccgt gatccgaatc ctcgataccg ccgcccttcg gaaccaggag gctcggcccg
    14881 atggactttg acctcagccc acagcagcaa cagcgcgtcg accacatgcg cgcaggcgcc
    14941 ggcaagcttc cggccacgga acccgacgga atcgctggaa aggacagttg gctggccgcg
    15001 gccgaactcg gcatgaccgg cctgtgcctg cccacggaac atggcggcgg cgggctcggt
    15061 gctctggaca cggcgctgtg cctcgaggcg ttctgcgccg gtggcgcgga caccggcctc
    15121 gccttcggca tcgcggcaca tctgcttgcc tgcgggaccg ttctggccga tcacgcgggc
    15181 gaaccggtgc gggccgagct gctccaggga ctggcctcgg gaactgttgt cgcggcgaac
    15241 gcgatgacgg aggacgatgc gggatccgac ctgagcagac tcaccacgac agccgtggcc
    15301 gacggtgaca gctacgtcct gaacggaagg aaatccttcg tcagcaacgc cccgctggcc
    15361 gacgtcttca tcacctacgc ggccaccgca ccgagcgccg gttacctggg gatgtcggcg
    15421 ttcgcggtcc cgcgaacttt gcccggcctg caggtcggtt ccctgctggc caagatgggg
    15481 ttgaacggct gcgccgccgc gcaggtcgag ttcactgact gcaaggtccc tggccgctac
    15541 ctgctgggcc cggagaacca ggggaacagc gtcttccagc gctccatgac ctgggaacgc
    15601 gcctgtctgc ccgcgatcta cctgggtgcg atggagggtc aactggccca gtgcgtggac
    15661 catgccagga gccgcaagca gttcggccgc agcatcggga acttccaggc gatctcccac
    15721 cggctcgcca ccatgaaact gaggctggaa accagccgcc tgcttctgta ccgcgcgtgc
    15781 tggtacctcg accaaggccg gccggccgtg gaggcggccg cattggccaa gacggcagtc
    15841 gccgaggccg ccgtagccaa cgcgctggac gcggtgcagg tgttcggcgc gcgggggtgt
    15901 ctggcagcag acggaatcgg ccagcagctg cagaacgcca taccgctgaa catcttctca
    15961 gggacgacgg agatgcaacg ggaggtcgtc gcgaagagca tggggttatg agcggccggt
    16021 cgagaaccgg ttcagcagat gatctctgac gcccggacca aagcctttcg tgccgtcagg
    16081 cgttccacat gaccaaccca ccttttctac tgcacccagg agccgaagca tgagtgaaag
    16141 gcgcggcctc cacgacctgc tgtccgcctc cgcagctcgc acgccggacg ctcctgccgt
    16201 cgtcggaccc gccggttcga tgagttacgg ggaactcgac gaacgagccg acgccctggc
    16261 cggcaggctg tccggccaag gaatcagcaa gggggaccga gtgctgatct ggtccccgaa
    16321 gtccgccaac gcgatcgccg ccatgcaggc ggtcttgcgg ctcggtgcga tctacatccc
    16381 ggtcgatccc ctcactcccc ccgagcggtt cctggtgatc gcgcgcgagt ccggggcgct
    16441 cgccctgtgc gctccggagg acctgtccgc gcgggtgcca agcccgcttc gcgactgcct
    16501 cgcgtgtgtc gacctcgacg ccgcgccggt gcccgacgct ctcccgcgta caccggtgag
    16561 cacgtgcgtc gaaccagacg atctcgccta catcctctac acctcgggct cgaccgggac
    16621 gccgaagggc gtctgcatca gccaccgcag cgccctggcc ttcatcgatt gggccgttgc
    16681 agaactcgcc cccggcccgc aggaccgctt tgccaaccat tcggggctct cgttcgacct
    16741 gtccgtcctc gacctctatg ccgccttcac cgtgggggcg gcggtgtgtc tgatacagcc
    16801 cgaattcgcc tacgtcccgg aagggctggt cgagttcctg caccgcgagc gcatcagtgt
    16861 gtggtactcc gtgccttccg cgctgatcct catgctgcgt gacggcggtc tgctcgaccg
    16921 gcccgcgccc gggacgctcc gcgcgctgct gttcgccggc gagccgtttc cgatcggccc
    16981 tcttcgagcc ctcgccgcct ggtccgacgc ccggctgctc aatctgtacg gacctaccga
    17041 gaccaacgtg tgcacctatc acgaagtccg ccccgcggac cttgcccgcg acctgccggt
    17101 cccgatcggg aagccgtgca gcggcgaccg ggtctgggct atccgcgccg acggttcgga
    17161 agccgaaccc ggtgaggagg gcgaactggt cgtcagcggg ccgacggtct tcgctggtta
    17221 ctggggccgg cagccgcagg agggcccgta cgcgaccggc gaccgagtca aggttcggcc
    17281 agatggttcg ttcgattacc tcgggcgccg cgacggcatg gtgaaaatcc gcggacaccg
    17341 gatcgaactc ggagacgtcg tcgcggcgct gtactcccat cagggggtcg ccgaggccgc
    17401 tgtcatcgcg gtgggcgacg ggttggaccg ggtcctggcc gcgttcgtgg tccgaagccg
    17461 gggaagcgcc ttcgggaacg tcgcgttgcg ccgacacctg gccggcagac tcgcacccca
    17521 catgatcccc ggtgacatcc gcttcgtcga ccggctgcct cacaacgatc gcgggaagct
    17581 cgacctcgcg gctctgcaga gaccactcca cggcccacag aaagttcaag ggtgagaaat
    17641 ggcaacccag acccgagaag acatttcgtc ccagctgctc accttcatcc gtgagagctt
    17701 cctggccggg gatcctgagg gtgagctcga cgcggatacc ccgttgctcg agctcgggat
    17761 actcaactcc ctgaacactg ccattctggt tgcgcatctc ggggaggatt acggcgtcca
    17821 cgtgccattg atcgacgtca ccgccactac cttcaagtcc gtgcgcaccc tgagtgagct
    17881 tgtgcatgag agcctgtcgc ggaagtaaat actgtcgtcc cagccaacta atagtctgga
    17941 tgtccaattg aaattgaacg cggacatgtt cctgctgcat gcgcccagcg tgtacgactt
    18001 ccgggaccgt gacgacatcc tgttcgccta cctgagtgac agcgacagcg tcaacgtcac
    18061 ctccgtatac gagatgtacc ccatcggctg gttctcgatc aagcaacagc tggccgacca
    18121 cgacttcgac tgtcagatcg tcaacatcgc ctccctgatg ttgacgcacc cgaatctcga
    18181 tgtggagcga ctgatcgggc ggttggaagc gccggtcttc ggtttcgacc tgcactggat
    18241 gacccagtgc aacggtgcga tcgagctggc caaggcggtg aagcggattc atcccgagtc
    18301 gctgatcgtc ttcggtggca tctcggccac gtacttcgcc cgggaactca tccggtaccc
    18361 gcaagtggac gtcgttgttc agggatacga cacgctcgcc cccatcaccc agctggtgga
    18421 ggctgtggtg cggggcggcc gagacttcag ctcgataccc aacctcctct acaagggcaa
    18481 tgaccgggtg gagaccacag gattcagcca caaacccacc tcggactaca acaacgtcag
    18541 gaatgactgg tcctactacc agaacacgcc tgtgacgccg ctttccagca agctcatcat
    18601 gacgctgccg aacaccgggt gcgcccacga ctgcggctgg tgcggcggct cccgcttcgc
    18661 ctatcgcaac atcatggagg tggacagaac cctcgtacaa aaggaccacg acctgatcgt
    18721 cgaggagctc aagacgatgg gggaggcggc cagacacacc tccatctacg ccctccagtg
    18781 ctactcggaa ggcaagacga ggatgcacgc atacctcgac gcagtgcgcg acctcgggta
    18841 ccggagtgtc ttcttcgagc agttcaacct gacgcccgac gacacgctga agaaaatggg
    18901 cacttccacg gactcgtaca tcatgctttc ccccgagtcg cacgacccga agatcagcaa
    18961 ggctgccggc cgcggcactt acacgatggc cgagatggag gaatggattc cacgcgcgtt
    19021 ggacgccggg gtcaagggcg tcatgatttg gtttttcatc ggcatgccgt atcaggacaa
    19081 gcagtccgtg cgcgacacgg ttgcctactc ggagcgcctg atcagcaaat tcgcgggatc
    19141 ttcggtcctt ccgctcatct gtcccatggt gcccttcctg gaccctggct gccgattctt
    19201 cgaggagccc gaaaagcacg gctaccgaat ccatcaccgt acgctggagc aacaccggca
    19261 ggccatggtc gaaccgctct ggtaccgtcg gctgaactac gagaccgagt ggctgagccg
    19321 acgcgaaatt caggatgtct cctacgaggc gatcgagcgg ctggtgagca tcaagggcga
    19381 gcacggtgtt ttgtccagcg tgttctgcga tgcggtgctg aagacgattg accagaccaa
    19441 acggctcctc gcggagatgg atcacgctct ctccctggac ggccggcttc ccgcaaccct
    19501 gcgggacgaa atgcgcgctt acaaccgcaa gatcctcgct tattccagcg accagatcct
    19561 gccgataccc cgccccttcg gcggacgctg gttcgatgac gtcacggtgc cggaggagat
    19621 gatccgcgag ctctccatga ccccgtgacc ccgccgagac agcacacttc tcaacagcag
    19681 gaaggaccga ctgagcatgg cgaaccacgg accggtggtc tatggcctgg aagtgcctgg
    19741 cgcgcgcctg cactacgaga tccaaggagc aggtcccctg ctcgtcgtgg tcggtttacc
    19801 catgggctgt aaagggttcg cgccgatctc gcggccgctg gccgagcact tcacggtcgt
    19861 gaccttcgac ccccgtgggg tccacagcag ccctgcggac gacccgaacc aggacgcact
    19921 ccccgaggtg atggccgacg acgtgcaccg gctcatttcg gcgctcgacg ccgggccggc
    19981 gtacttgttc gccagcagcg gaggcggtgt gaccgcgctc gcgctggctg cccagcaccc
    20041 tgaccaggtc aggacgctgg tcgcccacga gcccccgttg ctcgagctgt tgaccgaccg
    20101 cgtggaactg cgcgccgcca tcgatgagat ctgcgacatg taccgtgaga accgccccgc
    20161 ggcgttgcag aagtacctcg cccttgccga catccgcctg caccggccga ccccggaccc
    20221 gcccggaccg aatgcgttca ccgccccgtg ggacgtgtgg accatcctcg accggctctt
    20281 ccgtttcacc cttcgcccga ctacccgcta ccggcctgac atcgacgcgc tgcgacccat
    20341 ggccgaccga atcgtcatcg ccggcggatc caaggcccag ggctcgctct tccaccgcac
    20401 cgcggtcgca ctcgccgatc aactcggcac cgaactcgtc gactttcccg gcgaccacac
    20461 cggcttcctg accgattcgg agcccttcgc ccggttgctg ttcgaggtgt tcacgaaagc
    20521 gcgctcgcac aacggtccct aagatccgga accgaccggc atcacgccca cggaatccgc
    20581 gccatcgacg ccattctgtg tgtatttccg ttgcacggag gatcgcaagt ggtcgcagat
    20641 cgccgaagtg gcatgtaggc tcatttgaag attttgctcg ccgacgaggg caagaagttc
    20701 ccgtcctcga agctgcgaac cttccacacc atcgcatcgg cgaggcctcg gcgggcggcc
    20761 cttgtggaag agaactccct accgcgaacc ccgcgacgca gcctgcattc gcacgtcatc
    20821 ggcgcatcgg ggccgctcac cccgcccatc gttgagatca gttcactgac gcagcaccag
    20881 gggggatcga gatgaagatt gaaccgatta cgggatcaga ggccgaagcc tttcaccgga
    20941 tgggctcccg ggcgttcgaa aggtacaacg agttcgtgga cctgctggtc ggcgccggca
    21001 tcgccgatgg ccagaccgtg gtcgacctgt gttgtggttc gggggagctg gagatcatcc
    21061 tcacctcccg gttcccatcg ctgaacctgg tcggcgtcga cctctcggag gacatggtcc
    21121 gaattgcccg ggactatgcc gccgagcagg gcaaggagct ggagttccgt cacggggacg
    21181 cgcagtcccc ggccggcatg gaggatctgc tcggaaaagc ggatctggtg gtctcgcggc
    21241 acgcgttcca ccggctcacc cggctcccgg cggggttcga caccatgttg cgcctggtca
    21301 agccaggggg agccatcctc aacgtctcct tcctgcatct cagcgacttc gacgagcccg
    21361 ggttccggac gtgggttcgg tttctgaagg agcggccttg ggacgcggag atgcaggtcg
    21421 cctgggcgct ggctcactac tacgcgcccc ggctccagga ctaccgcgat gccctggccc
    21481 aggcggccga tgagacgccg gtgtccgagc agagaatctg ggttgatgac cagggctacg
    21541 gcgttgccac ggtcaagtgt tttgcccgtc gggccgctgc ctgaccggcc gttcggtccc
    21601 gctgctcagg atctggcgga cgttttgccc gtgactcggg cgagttgacg cccgccaccc
    21661 agatcgccgc ggtgctgccc tacgacccgc acacagcacg gccgtggatc gcccgccatg
    21721 acgtcgaagg agtcatcggg ctgccgagcc ggcctcgcag cggccggccc cggctgggca
    21781 gtccagccgg gccgacggat ccgtgccctg ctcgcctcgc tgaaggcgtg gagcgcccgc
    21841 tcgagaagat gggcgtccgg gaagaactcg aagacggcgg ctacacagag aattatggca
    21901 tcgagtcgtc agctacggat tcatcggact cacggcgtaa gtgcagtagg cggaaacttc
    21961 tgagcctcga tacctggacc cgaatggagg tggcacctat cgtaagcagg gtggcacaca
    22021 aactccgatc tcagcccgaa gaaaccaccc aaggaacagg cagcgactca tcgctgtatc
    22081 tggacctcat gatcaaggtg ttagccggga cggtgtatga ggatcctgcg caccgggaaa
    22141 acttctccca tcgcgattcg acgtaccggg aagaggtccg cagcgaggga cgcgactggc
    22201 cggcgaacgc gcacacgatg atcggaatca aacgcctcga aaacattcgg caatgtgtcg
    22261 aggacgttat tggcaacaat gtccccggtg acctcgtgga aactggggtg tggcgtgggg
    22321 gagcgtgcat cttcatgcgc ggaattctgc gcgctcacga cgtgcgcgac cggacggtgt
    22381 gggtcgctga ctccttccag ggcattcctg acgtcggtga ggacggccat gccggcgacc
    22441 ggaagatggc gctgcatcgg cgtaatgcgg tgctcgcggt gtccgaggac gaggtccggc
    22501 gcaacttccg caactacgat ctgctcgacg agcaggtccg gttcctcccc ggctggttca
    22561 aggacacgct gcccaccgcg ccgatcgacg cgctcgccgt actgcggatg gacggggacc
    22621 tgtatgaatc cacctgggat accctgacca acctctaccc gaaggtgtcc gtcggtggct
    22681 acgtcatcgt ggacgactac ctgatgtgcc cgccgtgcaa agacgcggtg gacgaatacc
    22741 gtgcgcggtt cggcatcgcc gacgagctga tcaggatcga ccgcgacggt gtctactggc
    22801 agcgcaccga gtaggttcac gacgactcga cgcctcgggt atgtggacca cccgggcgga
    22861 aggcacaaga acactaatcg cggacccgga tcagaatgcg gtgacccgta atgtgtactc
    22921 actcagaaca tcggtccgtg cagggctctg cagccacggg ggtattgcac cgagtcccca
    22981 actctctcag cttctattat cagcatctgc tcgtggccag tgagcggatc gataccacct
    23041 gggccagtac cgattcctgg ttcgaaccga gctggcaact tcccaaactc ggcccggagc
    23101 tggacgagtt cttttcggtc agcgggattt ccgccggcga acttggcgaa taccgaggac
    23161 gtcggcttca cttcctcgac ctgaccgaga acccgggcac acataccacg aagacgttcg
    23221 gctcctcagt gatcgtggcc cgcgcggtac ggcataccga actgaccggc gagccggtgc
    23281 tgctggtgac cccgtcggcg gccaacaagg cggtggcgct gcgcaacgcg gtgctacgcg
    23341 cctaccaggt cggcctgtcg gacccgagca agctgcgcgt ggtcaccgtg gtgccgtcca
    23401 gttcactgcc caaactgtgg gcctccgaca tcgatgccga tccggcgctg cgcgcggcca
    23461 acccgatggg cgtctactcc ggacccgagc gtgaacacgt caaggagatc acgacggccg
    23521 ccgtcggcga tctggccgcc gacgatcccg tcctgcgtgg atttcgagtc tggtacacgc
    23581 tgaacccgaa gaactacatg gtggccgact tcattcggac actgttcgag tatgagtact
    23641 tcccgcctgt cggtgagcgg tggcacaccc acgccgtctc cagcgcctac ggttttctcg
    23701 gacacgacct gggccggcag atggcggccg aggacggtgt ccggttcgac gtgccgcagc
    23761 gctacttgct ggtgcagcat ttggagacgc cggatctcgt cagcgccgtt accggaattg
    23821 acgtcgagac cgtggtccgg gatctctacc gggccaccgg tgacggcttg ctgaccaggc
    23881 cagcggacgc cgatccccgg ctgcccgagt actgctattc aaccggcgag cgcctggaac
    23941 ggaccttcta cacgcgcaat ccgccgacga cgaaagcggt ccggcaactg gtggccgacc
    24001 atggtggcaa cgggatcgtg gtttccctgc cggagtgcgt caaccgatat gccttcgtcc
    24061 gggatctgtt gcgcggcgcc gacttccacc ggctgccgga ggacccccgc cggctgcgcg
    24121 agtgggccat ggtgatgtcc gccgtcggct gcctcaacgc gatcgaccgt gacttgatcc
    24181 ccgccggcgc cgacgtggtc atccatggct cgggcgcgta ttccgaaggt gagttccacc
    24241 agatcgaccg gagtcggctg atcgaggtga acaccccgga cgaggtacgc gcgctcatca
    24301 gcggtgcgat ccaggcggac ggcgagcgtg gttgatgagt acagcggtgg tcaagcctgc
    24361 tgaggacgtg gccggtcggc tcgctcggat cctgacgacc ggtcggtccg gtccattcct
    24421 gggcaccccg tgcggcgtgc tcgcccagct gtaccgcgag atcgacgccg cgtgcgggat
    24481 gcggaccatc gcgcgggagg actccgcggt cggggtcgcg gccggcgcgg cactggccgg
    24541 ccggcagccg gtggtcttga tgcagaactc cgggttcggc cagtcggtca acgccttcgc
    24601 gtcattgatc atgccctgcc ggctcgacgt ggtcacggtc atcagcgtcc ggggcatggc
    24661 cccggacaac actgaggaga acagcgccat gggcacgctc actccgacga tcctggccgg
    24721 tctgaacgcg gacgtccgct ggctcgccga cggcgccgac ctgaccgagg ccactgccaa
    24781 ctggctcgcc accgaggtgg acgaaccacg gttcctgctc atcgcccctg gacttttcgg
    24841 ctggcgcccg tgacgatccg cacgatgacg cactcgccgc agaacaaggc ggcagccatc
    24901 gccgagatca tcggcgcgtc gggggacacg ccgatcgtgt tcaccaccgg ctatgcctgc
    24961 cgtatcgcca acgacatcca ggacaagccc gggcacttct acatgctcgg ctccatgggg
    25021 ctggccggct gtgtcgccgt gggcgtcgcg gccgggctgt cccgaccggt gatcgtcgtc
    25081 gacggggacg gctcgttggc gatgaatccc ggcgtgctgt tgctggccgc cgagttcacc
    25141 gggttgccgc tgatccacgt cgtgttggat gaccgcgcgt acagttccac aggcgcccag
    25201 cccaccccgc cggtcgggaa catcgagtcc tgggcggcct cgctcggcta tctggtgttg
    25261 tccccaccac tggccggcgg cgtcggctcc gtggtggccg gcctcctcgc cggcgagctc
    25321 acccgaccgc atctgttgcg cctcccggtc gcgccggacg ggcgcaacgt ccccggccgg
    25381 atcgagggcc gcctgtccgg atacgcggcc cggttccgca cgcactgccg aggcttgcgg
    25441 gccggctccg aactgcccgt cgtgtgaacg gtcggcggcc gtcgagaagt ggaaggtcga
    25501 tgcaacctgt tgagagcgga cgcggacgag cagtcggtac ctgcggcgag ctcgttcaag
    25561 gcacggttga cggccgcgag ctgatggtga cctttcctgt cgactggtac agcgacgtgg
    25621 tcgtgcgtgg ctcctacttg cccggcgtcc gggtgtggcc acggtcgaag gtcaaggtcc
    25681 gccggatgtg cgatgtgttg ctcgaccggc tggtcggagc cagttccgcc gatgtcgggc
    25741 tggacgtgct ggtcagctcg atgatcccgg agggccgcgg acacgcgagc agctccgcgg
    25801 acctgacggc gctgtgccgg gcgatggcgc agtggctcgg cgtgccgctc gccgacgacg
    25861 acatcatgcg gctgtgctgc gagctggagc cgtccgatgc ggtgtgccgt ccggtcccca
    25921 cgctgttcga cttcatccgc ggcgaggtgc tgttgtgcta cgacgacccg ccgccgatgg
    25981 ctgcgctggt gctggacgag ggtggggcgg tggacaccgt gaccatgcgg cggctgccct
    26041 gtaccgaggc cgagagcgag cggttggcct tggcgttcga cttggtggac cggggattcc
    26101 ggctgggtga tctcgcgttg atcggccggg ccgcgatgat cagcgccgag gtcaaccagc
    26161 ggcgggtgta caagcggaac ttcgaggttg ccagggacgt ggcggatgcc tgtggcagtt
    26221 acggagtgtc ggtcgcacac agcgggacca cgctggcact gctgttcgat cagcacgagg
    26281 tggagggcat ccgcgcggcc cacgcggcgc tgagaacagt cgccgccgac tgcgaactgt
    26341 ttctgctcaa cgcggtggtc ccgacgcggc gggcggcacc cgatctgacc gaactgccca
    26401 cccgctgacg gcgaacgagt ggggtgattc ccttttggcc ggttgattcc tcgggggtgt
    26461 cagtgggtgc catcagattc gctctgccga agcagggccg gccgatcagc atcgccgggt
    26521 accgaacggc cgcccgccgg gtcctgcccg acctggtgtg ggcgtacgtg gagaacggcg
    26581 cggacgattc cgtcacgttg gcggccaacc ggtctgcgtt cgcccgctgg tccctgcgtc
    26641 aacgagtgct gcgcagttcc gccgggcgga aaacggctgc ccggttcgga gacaccgagc
    26701 tggcgattcc ggtgatgatt gcgccgaccg ggatcaacgg actggtgcac tggcgcggcg
    26761 agttggcaac cgcatgcggt gcggccgcag ccggtagcag gatcgtgttg agcacggcag
    26821 cgtcttattc tgtcgaagag gtcgccgcgg cgagcccggt cggacactgg ctccaggtct
    26881 atccgtggcg cgatcgagaa ctcatggact ggctgctcga gcgcggccga cgatcggatt
    26941 gccccacgct ggtggtcacg gttgacacac cggtgttcgg aaaccgcgaa ccggaacggc
    27001 tgcagggcat gagcatcccg cccgtgctca cccccaggca cgtgttggac gccgcgctgc
    27061 acccccgatg ggcgtacaaa gtcctgcgcc accagcgggt gttcacgggc aacctggtcg
    27121 ggatgagcgg agtgagggcc ggcgcgctcg cagcgaaagt gcgccgggaa cggatgatgg
    27181 ccggcgaact cgactgggac gacttcgcca gggtccgcgc gcagtggcag ggactctgtt
    27241 acgtcaaggg aatcctggac gcagacgacg cagaacgcgc tgtctcgctc ggtgcggacg
    27301 ggatcatcgt gtccaatcac ggcggccgac agctggacgg cgccccggcc acactggacg
    27361 cgctgccggg gatcgccgac cggctggccc accgggccac ggtgctcatc gacggcggga
    27421 tccgcagagg caccgacgtg gtgaaggctc tgtgcctcgg tgcggacggc tgcctgatcg
    27481 gtcggccggc gctctacgga ctcgccgtgg gcggcgagtc cggggtcgaa cacgtgctca
    27541 gcatcctgcg cgaggaaatc gaccgcaccc tggcgctcat gggctgctcg gacatcgccg
    27601 atctcggccg ggactggctc atccccgggt agcaccgccg gcgccaccgg ggacggggtt
    27661 ccgccgaacg ggtgccgtgc atgggtcagt cgggctcgtc gccgtcggtg gccggggtgc
    27721 cgtgctgcgt ggacggtcgc cgatctctcg tggccaacag ggcgatgacg gtgatcagca
    27781 gtgtgatcgt gatcgccacg gtggagccga ggagcccgtc ggtggcggcg cggaggtggt
    27841 cgccggggtg ggcggtcagg gagccgaagt acagcgctcc gatgacggct atcccgatcg
    27901 tcgatccgat gcgctgccct gtttgcagga cggcgccggc ggcacttccc tcggtcaggg
    27961 gcaccgtttg cagagccagc gtcaggttcg gtccgatcac cagcccgctg cccgcgccgg
    28021 cgagcagcag cggcccggcc acgagcagcc acacaaggcc gcccgcgcgg tggccgatca
    28081 gggcgatcag cccggcggat cccagcgcga cggcggccag tccgatgacg accaaccggc
    28141 gtccgacccg gtggaccgcg cggccggcca ggggggcgct gatcgccgcg ccgagcgcag
    28201 tgggggtccc tacggcgcct gcggccagtg ccgagtaacc cagccccagt tggaagtaca
    28261 gcgataccat gaacgggatg ccgacaaagc cgacgaagta gcccatgccg acgaacgcgc
    28321 tgatcgcgta gtcgcgctgg cgcagcatcg cgaggttgac cagccgtggt cggccggagc
    28381 gcgtgcagtg ctgctgccag gcgatgaaac acgccagcag cagggccgac agcccgagca
    28441 ggtgccaggg caccgacggc tgtcgctgct cggccgcgat cagcggcagg atcaatgtgg
    28501 cgacaccgga tccgagcagt gctatcccga gcaggtcgag tcgcactcct cgtatctgct
    28561 gccgatcgcg ggggagccac cgcaggccca acgggagtga cagcgccgcg atgggcacgt
    28621 tcaccaagaa cacccatcgc catccgtcgg cagggccgcc ggcctggatc agcagaccgc
    28681 cgaccagcgg gccgatggcc gtagtcgcgg cgatcatccc gctgtacgcc ccgcctgcct
    28741 tgcccagttc cgggccccgt gcgaacagct gccgcatcag cccgaccacc tgcggcgtca
    28801 ccacccctgc ggcaaggccc tgcaccagcc tggcggccac gagccaccac ccggaggccg
    28861 ccagcccaca ggccaggctg ccgaacgcga agaaggccag ccccaccagc agcgtgcgcc
    28921 gtctgccgag ctgatcgccc agggccccgg cgggcaccag caccaccccg aaggtcagtg
    28981 tgtagccgaa cgccgcccac aacacctgcc cggccgacaa gtgcagcccg gcctgcatgg
    29041 aggggaccgc gacgttgatg acgctcacgt ccagcagcgt cacgaatccc gccagcaggc
    29101 acaccgaata cgctgcccag cgccctgcct gcactggttc ggccacgtcg gtctctgtca
    29161 taccggccct tccgccttgg ctgatcacgt ctactcgctg acttcacttc agccggtctc
    29221 accggagccg atcaatgacc aacatggtca tggaacaatc accggaagga atcgatcgag
    29281 gcgcggaggg cggtagtggt ggaggttcgg cagttgcgct acttcgtcgc cgtcgccgag
    29341 tgtgaacact tcggccgggc ggccgagacc ctgcacatcg ttcaagccgc ggtgagcaag
    29401 caggtcgcgc ggctggaacg cgaactcgga ctcacgttgt tcgaccggtc ccaccgccgg
    29461 gtccggctca ccccggacgg ccaggccttc ctggcccacg cacgccgcgc gctacgcggc
    29521 ctcgaccgcg ccgccgccgc ggcggccgac ctggccgccg gtaacacagg cttgctgcgc
    29581 atcggtagca gcattggact cggcccccgc gtcgacgccg cactcgcggc cgtccgcagc
    29641 gcgtaccccg gcatcacgct ccaggtgacg acctctgcct cgacaaccgg tcatctcgcc
    29701 gccgtcgccg actacgatct cgacgccgcc ttcgtggccg caccacaggc caccccgggc
    29761 gtgcaggttc accacctctg ggacgaaccg ttgctcctgg ccgtccccgc tgcacgcgcc
    29821 ggctccgcag gagacctcgc caccctcgct gaactccctc tggcccgata cgctcgcgcg
    29881 gacagccccg gtaccgacga cctgatcacc gccgcctgcc gggcggccgg gttcaccccc
    29941 cggaagggcc ccactctcac ccgagcccaa gacctcctca ccggacccgt ttccgccgga
    30001 gactgctggg ccgtactcgc cgcagacctc ctccaccacg tccccgccgc tgtcgccctc
    30061 gtcccgcccg ttccaccggt cctcgtgccc accgcactcg cgctacccga tcccgtacgc
    30121 cgtgcggtcg tgctcaacct gctcaccgtc gcacaggccg ggaccgtctg acgaccggtg
    30181 ttcccggccc gacacgccgg gtccatcccg tgaacggtgt tttcggtgtt ggccgcaggc
    30241 accacgaatg aacgccatat ctgatcttac ccatgtgatc ttggcgcaga aaatcgcacg
    30301 tcggcctgga gtgccgaagc tttccggggc ggggcaaccg gtccctgttc ggcccacgac
    30361 cactcaataa ccgtccaccg actcattcgc cttgacaaat atggcggccg ggctggaagc
    30421 tcacatgatg aatcggtggt tggttactgg tgcgggagga atgctcggga gggatttggt
    30481 gcgggttttg gaggcgctga acgaaccagt gctggctgcc actcggcagg atctcgacat
    30541 caccgaccga ttctcggtcc gagccgttgt ctccaggtat cgaccgacgg cgatcgtcaa
    30601 ttgcgcagca tggacgagat ttcatgaagc ggagaccagt gaagcggagg cccatcttat
    30661 caatggaaga ggggcaagag agctggctac gatatgcggc gatcgatcga ttcggttggt
    30721 ccatctctcc accgattacg ttttcgacgg cgcgagccgc cggccctatg ccgaaagcgc
    30781 ggccaccggt ccgatcaacg cctacggccg gacaaagctg gccggcgagc aagctgtgct
    30841 cgagttgctg ccggacgacg ggacgatcgt gagaaccgct tggctgtacg gtcgacacgg
    30901 cacgaacttc cttcgcaaga tggtccggtt ggagcagacg cacaagacgg tggacgtggt
    30961 agacgatcag tggggccagc cgacgtggag cgtggatttg gcacaacaga tcgtggcact
    31021 cgttcggcac ggtgcgtccg gcgtgttcca cgggacaagc tcaggcgaga ccacgtggta
    31081 cgacttcgcc cggatgatct tccggttgct cggtgcggat cccggacgaa tccgcccggt
    31141 gcgcagcgac cagatcgccg gcggcgaact gcgtccccgg tacacggtgt tggggcatgc
    31201 cgcctggcgc gaggtcgggc tgacgccgat tcggcactgg tccgccgctc tggagcggtc
    31261 gtttcccctt ctggctgacg aggaatggta atcctcctcg agtaaaagaa aggaggttcc
    31321 gcggatgcga cttctggtga cgggcggtgc cggcttcatt ggctcggagt tcgtccgggc
    31381 taccttacgt ggcgttctgc cgggctcatc aggaacccaa atcaccgttc tcgacaaatt
    31441 gacatattcc ggcaacgagc tcaacctggc accgatcgcg gacctggaga cttaccggtt
    31501 cgtgcaaggc gacatctgtg atcggggtct ggtggacgac gtggtcgccg gacacgacgc
    31561 gatcgtgcac ttcgctgccg agacgcatgt ggatcgctcg atcgaaggtg ccgcctcgtt
    31621 tgtccgtacg aacgcactgg gtacgcaggt gttgctggaa gcggcctccc gtcaccgact
    31681 ggggcggttc gttcacatct cgaccgacga ggtgtacgga tcgatttccg agggcgcctg
    31741 gaccgaggcg tccccggtgg ccccgaacgc accgtacgcg gcagccaagg cggcgggaga
    31801 cctgctggcg ctggcctggc accggacccg gaagctcgac gtcgtggtca ccagatgcac
    31861 caacaactat gggccgtacc agtatccgga aaagctgatc ccgctgttca cgaccaatct
    31921 cctggacggg cagcaggttc cggtgtacgg ggacggccac aaccgccgac agtggctgca
    31981 cgtgtcggac cactgtcgcg ccatccagtg cgtgctcctc ggtggtcggc ccggggaggt
    32041 ttaccacatt ggcggtggca ccgagttgac caacctcgaa ctgaccgaac acatcctcga
    32101 ggcctgtggt gccggttggg accgggtgcg gcatgttccg gacaggttgg gacatgatct
    32161 ccgctattcg ctggacacca ccaaaattcg tacggaactc ggttattcgc ctcgtgtggc
    32221 gttcgcggac gggctggcgg agacagtgga gtggtaccgc actcaccgtg gttggtggga
    32281 accgcttaaa aatcctgaca aagcgacggg ttcaccgacc gacgccggca gatgacggcg
    32341 caaccaggcg gagggacgcc tcgtggacgt cgtcactgat ctctcagcgg ttccgccctc
    32401 gaccagttgg acgccacggc accggtgagc tcggcgagca gttgccgtgc aggcgttgcc
    32461 ggacaccggt gtcgctccag gcccgcggcc gccgccggcg gaacagtggt tcgatccgca
    32521 tccagaactc gtcggacatt cccgtgaggg ggaggaagag atgcaggaca tcgtgcgtcc
    32581 catcaacgag tgccgggtgt gcgggcacaa cgattggctt gatgtggtct cgttcggatc
    32641 gacaccattg gccggaaacc tgctcggcac ggaagatgac ccgagggacg agactctgtt
    32701 cccgctggat gtcggcgtgt gccggaaatg ctggctgatg acactgcgcc atgtcatcga
    32761 accgaacgcc cttttcgggc actaccgtta cgtcgcctcg gacgcaggat cgatcatcca
    32821 gcacatgcgg cagctcgtcg aactgtgtat ccggtgggtc ggcctgaccg acagagatct
    32881 cgtcgtggag ttcggcagta acacaggtgc tcacctggag ctgttccagc aggccggcat
    32941 gcgggtggtc ggcgttgatc ccgcgcgcaa tctcgccgac atcgccaatg accgtggcgt
    33001 cacaacgatc cctgccggct tcaccaccga agtcggccag gagatcacga ctggacatgg
    33061 tccggcgcga ctggtgttcg gtcgccaatg tttcgcccac atccacgacg tccacgaagt
    33121 ccttgacgga gtctccgccc tgctggcgcc tgatggcctg ttcttcgtgg aagttcccta
    33181 tctggtggaa ctgctcgcaa acaatcagtt cgacaccatc tttcacgaac atctttccta
    33241 cttttcgctc ggcgcgctgt gcaggctgtt cgaggcgcac gggcttcgcg tcgtggacgt
    33301 acatacagtc gacgtgcacg gcggctcgat cgtggtcttc gccgccccgg ccaccgccgg
    33361 ctatgaggtg cggcccgctg ttgccgagat gctcgcggaa gaacgcagcc agggcatcgc
    33421 agaggagagt acataccaga aattcgccga gcgtacggaa cgggtgcgcg cacagatccg
    33481 ggaactggtg cgcagcttgg tggcagacgg caagacagtg gctggatacg gcgcaccgac
    33541 caaaggcagc gcactgctga ccgcatgcgg gctgggacat caggagatcc ggttctgcag
    33601 cgacacaaca gccctgaagc agggaaaact cctaccgggc tccagagttc cgatctggtc
    33661 gccggaacaa gcaagcgacc acgtaccgga ctactacctg ctgttggcct ggaactacgc
    33721 gtcggagatc atcaccaagg agaagtcgtt cctggaaggg ggcggccgtt tcattgttcc
    33781 catacccgaa ccgcgcgtga tatcggcgga gtcggcgtgg tgacgtcgaa ggctgcacca
    33841 acgatgatca ggcgttgtca ggttgctgat ggggtggctg gttgagggga atccttcttg
    33901 cgggcggtac cggctccagg ctgtggccgg tcacccgggc tgtttccaag cagttgatac
    33961 cggtcttcga caagccgatg atctactacc cgctgaccac gctgatgatg gccggcatac
    34021 gggagatact ggtgatcacg cgccccgagg accagcgcca gttccgtcac cttctcggcg
    34081 acggctcgca actgggcctg tgtcttgagt acgccgtcca agagaagccc gagggtatcg
    34141 cgcaggcgtt tgtcctgggt gccgacttca tcggcgacca gtcggtggcc ttggtcctcg
    34201 gggacaacat cttccatggc gcgggcctgg gaaccaggct gcgtcagtac agcgatcccg
    34261 ccgggggacg gatcttcgcc tacgtcgtag ccgaccccag ggcctacgcg gtagtggagt
    34321 tcgacgaggc cggtacggca gtctccatag aggagaagcc ggccagtccc aagtcgcgct
    34381 acgccgtgcc ggggttgtac ttctacgaca accgggtgct ggaggtcgcc cgcgacctga
    34441 tgccgagtca gcgtggcgaa ctggagatca ccgccgtcaa cgaaacctat ctgaaatggg
    34501 gccagttgcg ggttaccacg ctcgaccggg gcgccgcctg gctggacacg ggaacgttca
    34561 cctccttggt ccaggcgtcg gagtacgtgc gtgtggtgga agaacggcag ggcctcaaga
    34621 tcggctgcgt ggaagaggtc gcctggcgct gcggcctcat cgggaacgac cagttgcggg
    34681 aactcagccg cccactgctc aagagcggct atggccggta tctcctcgac ctgctcgccg
    34741 atcaggagtt gaaggagttg aagtcgtcgt gaaacttcgc ccgctcggca tcgagggcgc
    34801 ctgggagatc acccccaagc agcacgccga tccgcgcggg gtcttcctgg actggtaccg
    34861 cgtcgaccag ttcgccgcag aggtcggccg cccactgcgg ctggcccagg ccaacctgtc
    34921 ggtatccgtt cgcggcgtgg tgcgcggcgt ccacttcgcc gatgtgccgc ccgggcaggc
    34981 caagtacgtg acgtgtgtgc gcggcgcgct gttcgatgtg gtggtggacc tgcgggtcgg
    35041 ctcgccgact tacgggcgct gggaaggcac ccgactcgac gatgtcagcc gtcgtgccgt
    35101 ctacctctcg gaaggcatcg ggcacggctt ctgcgcgatc tcggacgagg ccacgctgtg
    35161 ctatctgtct tcgcagacct acaacccggc gtccgagcac ggtgtgcacc cgctcgatcc
    35221 ggaactggcc atcaattggc ccgtcgagac tccgctgctc tccgcgcgtg accaggacgc
    35281 gctcctgctc gccgaagccc gggactgggg cctgctgccc agctatgcgg cctgtcaggc
    35341 gctcacggcg ttgaccagtc aatgacggtc ttggcgtgcc gaccgaaggg ccggcacgcc
    35401 acggcggcgg gtgacgggga cgacggcgtc cgacacgggc gtccagaagg cggcacgcgt
    35461 cctcggcctc cctgacgcac ggcccgagcg ccgagccggc gatccgggtg ccatcccgcc
    35521 cctcgacaac cggagttcgg tgcgaggccg ggaccggcgg cctgacacag cgcgactggc
    35581 gaccgcggag ggttacgccg gaaatagtgc cccgggcgct acgtgacaag gcatcaagaa
    35641 accccctgag tgcccctctg tcgcattttc agtgggtcaa ggcagagggg atcggcctag
    35701 gtggcgcggg agtcgcacgg tggcgtacag gggtgctctc gtcccgtcgg ccagggatgg
    35761 ctccggtacg ctcggcagcg tctcggtcgg cgacatccag tggttcgtgt gccttggggt
    35821 cctgtccggg ctgtcgtgcc gtgtctcccc agctgtccgg ccgctcctgc atcgtggtgc
    35881 gggagccggg tccgctatgc ccgaaagaga gcgtctgtga ctacttacga cactcgcacc
    35941 gccaccgaca cccgcggatc cgagcagccc ggccacgtgg ggacggcgtc gtatgacgcc
    36001 aacgcgatca ccgttctgga cggcctggac gccgtacgca aacggcccgg gatgtacatc
    36061 ggctctaccg gggagcgggg gctccatcac ctggtgcagg agctcgtgga caactccgtg
    36121 gacgaggcac tcgcgggggt ggccgaccgg atcgacgtga cggtcctggc cgacggcggg
    36181 gtgcgggtgg tcgacaacgg ccgcggcatc ccggtgggga tgcacccggt ggagaagcgg
    36241 ccggccgtcg aggtggtgct gaccgtgctg cacgcgggcg ggaagttcgg gggcggcggg
    36301 tacgcggtct ccggcggtct gcacggtgtg ggtctgtcgg tggtcaacgc cctgtcgacc
    36361 cggctgtcgg cggagatctg gaccgacggc caccggtgga cgcaggacta cagggacggc
    36421 gctcccaccg ccccactggc ccgccacgag gccacctccc ggacgggcac ctcgctgacg
    36481 ttctgggcgg acggcgacat cttcgagacc accgaatact ccttcgagac gctggccagg
    36541 cgtcatcagg aaatggcctt cctcaatggt gggctcaccc tgaccctcac cgacgaacgg
    36601 tcctccgcgc gcgcgacggc cgcggtcgac gaagccgact cggacccgac ggcgaagacg
    36661 gtctcctacc gctacgacgg cggcatcacc gacttcgtcg tccacctcaa tgcccgcaag
    36721 ggcgagccgg cccatccctc ggtcatcacc atcgccgccg aggacacgga acggctgttg
    36781 tcggccgaga tcgccctgca gtggaacggc cagtacaccg acagcgtgta ctcctacgcc
    36841 aacgcgatcc acacccatga gggcggcacc cacgaggagg gcttccgcac ggcactgacc
    36901 accgtggtca accgctacgc gcgggagaag aggctgctgc gggacaagga cgcgaacctc
    36961 tccggcgagg acatccgcga gggtttgacc gcgatcatct cggtcaagct cggcgaaccg
    37021 cagttcgagg gccagaccaa gaccaaactc ggcaacaccg aggtgcgcac cttcgttcag
    37081 aagatcgtcc acgagcacct ggccgactgg ttcgaccgca acccgaacga ggccgtggac
    37141 atcgtgcgca aggccgtcca ggccgccacg gcccgggtcg cggcccgcaa ggcgcgcgac
    37201 ctgacccgcc gcaagggcct gctggaaacg gcggcgctgc cgggcaagct gtccgactgc
    37261 cagtcgaacg acccggcgac gtcagagatc ttcatcgtcg aaggagactc cgccggcggc
    37321 tctgccaaag ccggccgcaa tccgcagtac caggcgatcc tcccgatccg cggcaaaatc
    37381 ctgaacgtcg agaaggcgcg gatcgacaaa gtactgcaga accaggagat ccaggcgctc
    37441 atctccgcgt tcggcacggg tgtgcacgag gacttcgaca tcgccaagct ccgttaccac
    37501 aaaatcattc tgatggcgga cgcggacgtc gacggccagc acatcagcac cctgctgctg
    37561 accttcctct tccgcttcat gcggccactg gtcgaggagg ggcacgtcca cctctcccga
    37621 ccgccgctgt acaagatcaa gtggagtcgg gaacacgtcg aatacgccta ctccgaccgc
    37681 gaacgcaaca cactcctgga acggggccgc cgggacggcc gccggatcag ggacgactcc
    37741 atccagcgct tcaagggtct gggcgagatg aacgccgagg aactgcgcgt caccaccatg
    37801 gaccccgacc accgggtcct gggacaggtc accctcgacg acgcggcttt cgccgacgac
    37861 ctcttctccg tcctgatggg cgaggacgtg gaagcccgcc gccacttcat ccagcgcaac
    37921 gcccaggacg tccgcttcct cgacatctga ccccggacac cgctcccgcc cctctcgacg
    37981 cgtgacccaa agccccaccg ctacctctgt tactcaggag agcactgcgt gagtacattc
    38041 cccgccccgg ccgccggcag ccgcccccag gacggctccg actacaccgc acggcacctg
    38101 atggtgctcg acgggctcga agccgtgcgc aagcgcccgg gcatgtacat cggatccagc
    38161 gacagccgcg gtctgatgca ctgcctgtgg gagatcatcg acaactccgt ggacgaggcc
    38221 ctggccggtg cctgcgacca catcgaggtc atcctccacg acgacggttc cgtggaagtc
    38281 accgacaacg gccgcggcat ccccgtggac acggaacccc gcaccggcct gtccggagtc
    38341 gagctcgcct acaccaaact ccacgccggc ggcaagttcg gcggcggctc gtacgccgcc
    38401 tccggcggcc tgcacggcgt cggcgcctcc gtggtcaacg cgctgtccgc ccggctggac
    38461 atcgaggtcg accgccacgg ccgcacacac gccatcagct tccgccgcgg cgcacccggc
    38521 acctactccg cccctggacc cgacgccccc ttcacccgcg cccagggact gcaccggacc
    38581 gccagaatcc ccaagtcacg gaccggcacg cgcgtgcggt actgggccga ccgtcagatc
    38641 ttcctcaagg acgccaagct ctccctggag aacctccatc agcgcgcccg ccagacggcg
    38701 ttcctggtgc cgggcctgac catcgtcgtg cgcgatgagt acgggctcgg tgagggcggc
    38761 agcaagggcg aggagtcctt ccgtttcgac ggcggcatca gcgagttctg cgagtacctg
    38821 gccgccgaca agccggtctg cgacgtcctg cgcctcaccg gccagggcac gttcaaggag
    38881 acggtcccgg tcctggacga gcacgggcag atgaccccga ccgaggtcac ccgcgagctc
    38941 ggcgtggatg tggcgctgcg ctgggggacc ggttacgaca cgacgctgcg gtcgttcgtc
    39001 aacatcatcg ccacgcccaa gggcggcacc catgtcgccg ggttcgagca ggccgtggcc
    39061 aagacgatga acgaggtgct gcgggccaag aagctgctgc gcgtcgcgga ggacgacatc
    39121 gtcaaggacg acgcgctgga gggtctgacg gccgtcgtca ccgtgcgcct ggccgaaccc
    39181 cagttcgagg gtcagaccaa ggaggtcctg ggcacctcgg cggcccggcg catcgtgaac
    39241 accgtgatct ccagggagct gaaggcgttc ctgacctcca ccaagcgtga cgcggccgct
    39301 caggcgcggg tcgtgatgga gaaggcggtc gccgccgcgc gcacgcgtat cgcggcgcgg
    39361 cagcacaagg acgcacagcg tcgcaagacg gcgctggagt cctcgtccct gcccgccaag
    39421 ctggccgact gccgcagcga cgacgtcgag cgcagcgaac tgttcatcgt cgagggcgac
    39481 tcggcgctcg gtacggcgaa gctggcccgc aactccgagt tccaggcgct gctgccgatc
    39541 cggggcaaga tcctcaacgt ccagaagtcg tccgtgaccg acatgctgaa gaacgccgag
    39601 tgcggggcga tcatccaggt cataggggcg ggctccgggc ggaccttcga catcgacgcg
    39661 gcccgttacg gcaagatcat catgatgacc gacgccgatg tggacggttc ccacatccgg
    39721 acgctgttgc tgacgctgtt ccatcgctac atgcggccca tggtcgagtc gggccgggtg
    39781 ttcgccgcgg tgccgccgct gcaccgcatc gagctggtcc agcccaagaa gggccaggac
    39841 aggtacgtgt acacgtactc ggaccgggag ctgcgcgaca ggctcatgga gttccagagc
    39901 aagggcgtga ggtacaagga ctccatccag cgctacaagg gtctgggcga gatggacgcc
    39961 gatcagctgg ccgagacgac gatggacccg cgtcatcgca ccctgcgacg catcaacctc
    40021 tccgacctgg aggccgccga gcaggtcttc gacctgctca tgggcaacga tgtggcgccg
    40081 cgcaaggagt tcatctccag ctccgcggcc acgctggacc ggtccaggat cgatatctga
    40141 gctcgactct gtcgcggatc tcgagaagct cggggttcat ccgccggtga acggccaaga
    40201 ccgcggccgc
//
