LOCUS       BGC0000833             37834 bp    DNA     linear   BCT 25-JUL-2016
DEFINITION  Streptomyces rishiriensis strain DSM 40489 hypothetical protein
            gene, partial cds; putative FK506-binding protein gene, complete
            cds; coumermycin A1 biosynthetic gene cluster, complete sequence;
            and DNA gyrase subunit B (gyrB-Rc) and DNA gyrase subunit B (parYR)
            genes, complete cds.
ACCESSION   BGC0000833
VERSION     BGC0000833
KEYWORDS    .
SOURCE      Streptomyces rishiriensis
  ORGANISM  Streptomyces rishiriensis
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     On or before Sep 21, 2011 this sequence version replaced
            AF205853.1, AF235050.3.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:45:29
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2306
            Orig. end    :: 40140
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..654
                     /codon_start=1
                     /gene="couE"
                     /gene_functions="biosynthetic (rule-based-clusters) other:
                     LmbU"
                     /gene_kind="biosynthetic"
                     /note="similar to NovE protein from Streptomyces
                     spheroides"
                     /product="regulatory protein CouE"
                     /protein_id="AAR11885.1"
                     /sec_met_domain="LmbU (E-value: 2.6e-84, bitscore: 272.9,
                     seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVASGQTASKAGGSGATPVRPTAGDATPVDSRKSSHASCLGVEVS
                     AERTRLQIPQDLSLEAWCRLGGRILTVCDSSAWWIGDWLVFGQNQYGDRYRRAMEKTKL
                     DYQTLRNYAWVARKFEPSRRRDRLTFQHHMEVASLSQAEQDHWLDFAVRLNWSRNQLRK
                     QIRASISGEEDDLRRHVQLSLQLDELRLERWREAARGSNLTLTDWILFVVDEAI"
     subregion       1..37834
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Saccharide, Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..37834
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..654
                     /gene="couE"
     misc_feature    1..33059
                     /note="coumermycin A1 biosynthetic gene cluster"
     gene            1808..2767
                     /gene="couG"
                     /note="cumA"
     CDS             1808..2767
                     /codon_start=1
                     /gene="couG"
                     /note="putative regulatory protein; CouG"
                     /product="regulatory protein CouG"
                     /protein_id="AAG29778.1"
                     /transl_table=11
                     /translation="MSNSGDEEMTSILPKAIGKGERVPIGSLFPSQQLLRSGESTEHIR
                     ALVETEEVLPPIVVHRETRRVIDGMHRLRAARFRGDEWIEVVFIDDASADVFVLAVELN
                     RAHGLPLTMAERKSAAARIMDSHPHWSDRKIARTTGLAASTVASLRSHSIAGTLERRTG
                     QDGRTRPKDGTEGRRRASELLAQNPNASVREVAKAARISVGTASNVRARLRRGEPAITA
                     LQQAALTPRPASATQRTGPDYSRVLQSLRNNPSLRFNDVGRHLLRLLGGAAPGSVEQIA
                     QIADSVPEHCRVMVIDMARECAAAWQHLADRLAGRDTA"
     gene            3104..3319
                     /gene="couY"
                     /note="cumB"
     CDS             3104..3319
                     /codon_start=1
                     /gene="couY"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009:mbtH-like protein (Score: 107.9; E-value:
                     2.5e-33)"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to Mycobacterium tuberculosis MbtH"
                     /product="mbtH-like protein"
                     /protein_id="AAG29779.1"
                     /transl_table=11
                     /translation="MATNPFDDENGVYLLLVNDEGQHSLWPSFAALPKGWTVILDEASR
                     QECLDYVNEHWTDMRPLSLQPAMGDE"
     gene            3625..5424
                     /gene="couH"
                     /note="cumC"
     CDS             3625..5424
                     /NRPS_PKS="Domain: AMP-binding (26-424). E-value: 6.6e-101.
                     Score: 329.7. Matches aSDomain:
                     nrpspksdomains_couH_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (530-596). E-value: 4.9e-18. Score:
                     57.0. Matches aSDomain: nrpspksdomains_couH_PCP.1"
                     /codon_start=1
                     /gene="couH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     376.6; E-value: 2.6e-114)"
                     /gene_kind="biosynthetic"
                     /note="CouH"
                     /product="peptide synthetase-like protein"
                     /protein_id="AAG29780.1"
                     /sec_met_domain="novH (E-value: 0.0, bitscore: 1113.4,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSKGLNKASDRSATTRTASATLAELWERTVRSRPSSPAIVSNSE
                     TLSYDEVNARANQLARLLLSEGAGPGRVVALALPRSSRMVISVLAVAKAGAAFLPVDVN
                     YPEQRIAYMLADAEPALLCTIRTAVPKLPADIGVPQLVLDSAEQTATLDALPDTDVTED
                     ERGGSLAATNLAYVIYTSGSTGRPKGVALTGAGLPALAAAKVATMQVTEDSRVLQFASP
                     SFDAYVTELLATFTSGATLVVPGSDTLVGDPLAKVLREGQVSHAVLPPAAVATMSPDAA
                     PDLRVLVVAGEECPAGLVEQWSPGRLLVNAYGPTECTVCATMTGPLTPTDEVTIGRPIP
                     GVSVHILDDELLPVAAGEIGELYLSGAGLARGYLNRPDVTAHVFVANPFAADGERMYRT
                     GDLASMRADGDILFHGRIDDQVELRGFRIELGEVESVLSQHPDVAQAVAVLRAGEDDGP
                     QLLAYVVPTHGTTPAAGELREHAGRYLPDYMVPSVYATIDAIPVTPSGKTDRAALPPIK
                     TTRPAGQKPRTSAEKILFDIFRDLFGLGEIDVRSNFFEMGGNSILAVDLIQRAQEAGLV
                     LLPRTVIDHPTIEQLAAIANLGE"
     aSDomain        3703..4896
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couH_AMP-binding.1"
                     /evalue="6.60E-101"
                     /label="couH_AMP-binding.1"
                     /locus_tag="couH"
                     /protein_end="424"
                     /protein_start="26"
                     /score="329.7"
                     /tool="antismash"
                     /translation="WERTVRSRPSSPAIVSNSETLSYDEVNARANQLARLLLSEGAGPG
                     RVVALALPRSSRMVISVLAVAKAGAAFLPVDVNYPEQRIAYMLADAEPALLCTIRTAVP
                     KLPADIGVPQLVLDSAEQTATLDALPDTDVTEDERGGSLAATNLAYVIYTSGSTGRPKG
                     VALTGAGLPALAAAKVATMQVTEDSRVLQFASPSFDAYVTELLATFTSGATLVVPGSDT
                     LVGDPLAKVLREGQVSHAVLPPAAVATMSPDAAPDLRVLVVAGEECPAGLVEQWSPGRL
                     LVNAYGPTECTVCATMTGPLTPTDEVTIGRPIPGVSVHILDDELLPVAAGEIGELYLSG
                     AGLARGYLNRPDVTAHVFVANPFAADGERMYRTGDLASMRADGDILFHGRIDDQVELR"
     aSModule        3703..5412
                     /complete
                     /domains="nrpspksdomains_couH_AMP-binding.1"
                     /domains="nrpspksdomains_couH_PCP.1"
                     /locus_tags="couH"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       3889..3930
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0001"
                     /evalue="1.50E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="couH"
                     /protein_end="102"
                     /protein_start="88"
                     /score="15.1"
                     /tool="antismash"
                     /translation="LAVAKAGAAFLPVD"
     CDS_motif       4147..4203
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0002"
                     /evalue="9.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="couH"
                     /protein_end="193"
                     /protein_start="174"
                     /score="30.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVALT"
     CDS_motif       4558..4584
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0003"
                     /evalue="1.10E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="couH"
                     /protein_end="320"
                     /protein_start="311"
                     /score="11.5"
                     /tool="antismash"
                     /translation="YGPTECTVC"
     CDS_motif       4690..4776
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0004"
                     /evalue="9.40E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="couH"
                     /protein_end="384"
                     /protein_start="355"
                     /score="46.7"
                     /tool="antismash"
                     /translation="AGEIGELYLSGAGLARGYLNRPDVTAHVF"
     CDS_motif       4861..4926
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couH_0005"
                     /evalue="9.00E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="couH"
                     /protein_end="434"
                     /protein_start="412"
                     /score="33.8"
                     /tool="antismash"
                     /translation="FHGRIDDQVELRGFRIELGEVE"
     aSDomain        5215..5412
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couH_PCP.1"
                     /evalue="4.90E-18"
                     /label="couH_PCP.1"
                     /locus_tag="couH"
                     /protein_end="596"
                     /protein_start="530"
                     /score="57.0"
                     /tool="antismash"
                     /translation="EKILFDIFRDLFGLGEIDVRSNFFEMGGNSILAVDLIQRAQEAGL
                     VLLPRTVIDHPTIEQLAAIAN"
     gene            5428..6651
                     /gene="couI"
                     /note="cumD"
     CDS             5428..6651
                     /codon_start=1
                     /gene="couI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 316.8; E-value: 3.3e-96)"
                     /gene_kind="biosynthetic"
                     /note="CouI"
                     /product="cytochrome P450"
                     /protein_id="AAG29781.1"
                     /sec_met_domain="p450 (E-value: 2.7e-15, bitscore: 47.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="novI (E-value: 5.6e-260, bitscore: 852.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRPMVSADELEDIDLASPILHAEYELDAVFRHLRANRPMYWQQ
                     PRGEQPGFWVISRYADVNEVYKDKAHFTTENGNALATLLTGGDSASGAMLAVTDGVRHH
                     QVRNLLSKGFSPQMLELIANSLRETVDGLLLAALDRGECDAARDISAKVPLGAICDLLE
                     IPQTDREYLLGLTAHAWSTDYADEPPEESWVAKNEILLYFSKLLKERRGGDRDDMVSLL
                     ANCRIDGHPLNAAEQIANCYGLMIGGDETGRHAITGTVLALIENPDQWRALKNGDVDLK
                     TATEEALRWTVPSLHGGRKATGDVVINGQQIKAGEVVSVWISSANRDETVFDAADEFKL
                     ARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYSSILHGMS
                     SLPIKITA"
     gene            6811..7587
                     /gene="couJ"
                     /note="cumE"
     CDS             6811..7587
                     /NRPS_PKS="Domain: PKS_KR (13-185). E-value: 2.4e-22.
                     Score: 71.6. Matches aSDomain:
                     nrpspksdomains_couJ_PKS_KR.1"
                     /codon_start=1
                     /gene="couJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     244; E-value: 2.7e-74)"
                     /gene_kind="biosynthetic"
                     /note="similar to 3-ketoacyl-[ACP]-reductase"
                     /product="b-ketotyrosyl-reductase"
                     /protein_id="AAG29782.1"
                     /sec_met_domain="adh_short (E-value: 3.2e-38, bitscore:
                     122.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="novJ (E-value: 5.7e-153, bitscore: 498.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPAASAVACEPVAMVTGAGRGIGAATAERLAAEGMAVIVVDRV
                     EQDTTATVSAIRAAGGRASGLGCDVSVAQAVTATVASAVEEFGHLDVLVNCAGITQDRL
                     LLTMSDQEWDRVLDVNLGGSMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTNYATA
                     KGAIAGFTRTLAAEFGPHGVTVNSIAPGFVATPMVAELTERLGVDRDTVLLEAAMSSAV
                     GRIGTPEEIAAVVAFVTRPESGYLTGETIHVEGGRR"
     aSDomain        6850..7365
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couJ_PKS_KR.1"
                     /evalue="2.40E-22"
                     /label="couJ_PKS_KR.1"
                     /locus_tag="couJ"
                     /protein_end="185"
                     /protein_start="13"
                     /score="71.6"
                     /tool="antismash"
                     /translation="VAMVTGAGRGIGAATAERLAAEGMAVIVVDRVEQDTTATVSAIRA
                     AGGRASGLGCDVSVAQAVTATVASAVEEFGHLDVLVNCAGITQDRLLLTMSDQEWDRVL
                     DVNLGGSMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTNYATAKGAIAGFTRTLAA
                     EFGPHGVTV"
     CDS_motif       6859..6933
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couJ_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="couJ"
                     /protein_end="41"
                     /protein_start="16"
                     /score="11.1"
                     /tool="antismash"
                     /translation="VTGAGRGIGAATAERLAAEGMAVIV"
     CDS_motif       7240..7299
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couJ_0002"
                     /evalue="1.20E-06"
                     /label="PKSI-KR_m4"
                     /locus_tag="couJ"
                     /protein_end="163"
                     /protein_start="143"
                     /score="21.0"
                     /tool="antismash"
                     /translation="INFSSVAARGNAGQTNYATA"
     gene            7584..8321
                     /gene="couK"
                     /note="cumF"
     CDS             7584..8321
                     /codon_start=1
                     /gene="couK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     92.4; E-value: 5.3e-28)"
                     /gene_kind="biosynthetic"
                     /note="CouK"
                     /product="b-ketotyrosyl-reductase"
                     /protein_id="AAG29783.1"
                     /sec_met_domain="novK (E-value: 1.4e-132, bitscore: 431.7,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGVAVVAGGGEHTGPAVAVRLAGRGFDVALLDTEFTAADKTVRQ
                     IEESGRRCVTVEAELTDTRSVGAAFGQVRSALSSPVVLVTCVGPGPVPDGSPEDELADE
                     QRYGVVRRALRSAFVCCQAGAGHLLHHRWGRIIIVTEPVDAGGNAWRTSQPVLAGLIGF
                     TRSAALELARSGITVNLIAPAESAVDSRAPAHQPAVNVGAGSYAEGVAHVTAFLIDDQA
                     VGITGQEIYLAAAQAGVPLLRER"
     gene            8328..9917
                     /gene="couL"
                     /note="cumG"
     CDS             8328..9917
                     /NRPS_PKS="Domain: AMP-binding (17-421). E-value: 4.3e-76.
                     Score: 247.9. Matches aSDomain:
                     nrpspksdomains_couL_AMP-binding.1"
                     /codon_start=1
                     /gene="couL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     289.9; E-value: 5.1e-88)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouL"
                     /product="amide synthetase"
                     /protein_id="AAG29784.2"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-77, bitscore:
                     250.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANRDHGPEHYVTRILDEAARDGARPVVRWRDTVITGTELHRSVR
                     RVATALREAGVARDHAVAILTQVNSPWMLVVRYAAHLLGASVVYITGANHGTVTHDLPV
                     TTRVRMMREAGASVLVFDERNAQLAETIRETVPDKLVLCGLGHPASGTVTADGRPVEDV
                     AVEFPAETPELAMVLYTSGTTGQPKGVCKPFGAWNATVVGLAGQPRPRQTYLAMTAVSH
                     TVGMVVDIALAAGGSVLLREKFDPTDFLRDVVTHRVTDTFMGVPQLYAILNHPDVRTTD
                     LSSLQHLVYVGCPASPERLREAVTVFPGVLWQSYGSTETGRIAMLREDDHDHPELLATV
                     GRPMPGVTIAIRDPQTGRDLPVNEIGEVVVHSPNNMAGYIGDPEGTTRVVRDGWVHTGD
                     MGSVDERGYVRLFGRMHEMVKVQDTRVSPTEVEKVLVGCPGVVDACVYGHRRPDLIEEL
                     HAAVVLSTEDAPSFAALRDHVAQTMTPTHAPVRFVRWRQFPINNTGKTDRLRIREVSAE
                     ARGEGPDVLVDR"
     aSDomain        8379..9590
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couL_AMP-binding.1"
                     /evalue="4.30E-76"
                     /label="couL_AMP-binding.1"
                     /locus_tag="couL"
                     /protein_end="421"
                     /protein_start="17"
                     /score="247.9"
                     /tool="antismash"
                     /translation="EAARDGARPVVRWRDTVITGTELHRSVRRVATALREAGVARDHAV
                     AILTQVNSPWMLVVRYAAHLLGASVVYITGANHGTVTHDLPVTTRVRMMREAGASVLVF
                     DERNAQLAETIRETVPDKLVLCGLGHPASGTVTADGRPVEDVAVEFPAETPELAMVLYT
                     SGTTGQPKGVCKPFGAWNATVVGLAGQPRPRQTYLAMTAVSHTVGMVVDIALAAGGSVL
                     LREKFDPTDFLRDVVTHRVTDTFMGVPQLYAILNHPDVRTTDLSSLQHLVYVGCPASPE
                     RLREAVTVFPGVLWQSYGSTETGRIAMLREDDHDHPELLATVGRPMPGVTIAIRDPQTG
                     RDLPVNEIGEVVVHSPNNMAGYIGDPEGTTRVVRDGWVHTGDMGSVDERGYVRLFGRMH
                     EMVKV"
     CDS_motif       8850..8900
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couL_0001"
                     /evalue="1.80E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="couL"
                     /protein_end="191"
                     /protein_start="174"
                     /score="23.5"
                     /tool="antismash"
                     /translation="AMVLYTSGTTGQPKGVC"
     CDS_motif       9408..9488
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couL_0002"
                     /evalue="4.90E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="couL"
                     /protein_end="387"
                     /protein_start="360"
                     /score="15.7"
                     /tool="antismash"
                     /translation="PVNEIGEVVVHSPNNMAGYIGDPEGTT"
     gene            9931..11139
                     /gene="couM"
                     /note="cumH"
     CDS             9931..11139
                     /codon_start=1
                     /gene="couM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 286.2;
                     E-value: 8.2e-87)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouM"
                     /product="glycosyltransferase"
                     /protein_id="AAG29785.1"
                     /sec_met_domain="MGT (E-value: 2.8e-116, bitscore: 379.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFTSLPGIGHLFPMVPLAWALQAAGHTVLVATDREFLPVVTG
                     AGLPAAAVRDPVDPVELFKPVSLSGLSGLLGLSGGPVSPAERTGHRCAEIGVRALAAVR
                     ALVDAWRPDLVIAEPMELAGPAAATIAGVPWVRHSYGLIPPERLLSAAAAALDSELAVR
                     GLSPWAEPAGTIDVCPDSLQPSDAVATMPMPMRYVPYNGPAVVPDWLLAGPSPRPRVCL
                     TLGTSLPRRNPRVAPLWRLLLDELVALGQEVVIAIDESHRSLLGHLPGGVRAARIPLCD
                     LLPTCTAIVHHGGSGSTMAAAAFGVPQLVVPHFADHFANAERIIAVGAGTSLPHDTDDL
                     ARITAACALIVDDGPHRAISARLAEENASRPKPTEVAQDLVALVLEHSQDVLRPQHASQ
                     GRQ"
     gene            11220..11507
                     /gene="couN1"
                     /note="cumI"
     CDS             11220..11507
                     /NRPS_PKS="Domain: PP-binding (32-82). E-value: 4.3e-07.
                     Score: 22.3. Matches aSDomain:
                     nrpspksdomains_couN1_PP-binding.1"
                     /codon_start=1
                     /gene="couN1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN1"
                     /product="acyl carrier protein"
                     /protein_id="AAG29786.1"
                     /sec_met_domain="PP-binding (E-value: 2.5e-07, bitscore:
                     22.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTGRTELEHVLTRLEMLLNDVWDQRPAGVAMSATAPLVSLGVDS
                     LTLALLLDNVGREFHIDWTADTRLGGAISLRSLADLVLRRDGGPAAAAEA"
     aSDomain        11316..11465
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couN1_PP-binding.1"
                     /evalue="4.30E-07"
                     /label="couN1_PP-binding.1"
                     /locus_tag="couN1"
                     /protein_end="82"
                     /protein_start="32"
                     /score="22.3"
                     /tool="antismash"
                     /translation="SATAPLVSLGVDSLTLALLLDNVGREFHIDWTADTRLGGAISLRS
                     LADLV"
     gene            11518..12585
                     /gene="couN2"
                     /note="cumJ"
     CDS             11518..12585
                     /codon_start=1
                     /gene="couN2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: ksIII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 102.6; E-value: 3.8e-31)"
                     /gene_kind="biosynthetic"
                     /note="CouN2; similar to Streptomyces peucetius DpsC"
                     /product="acyltransferase"
                     /protein_id="AAG29787.2"
                     /sec_met_domain="ksIII (E-value: 2.1e-77, bitscore: 251.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSGTYLAGIGVFRPKTKSVDAAVRQGLVSKESADASGITGVSV
                     AGDVSPAEIALIAARQALHSSGLSADDIGLLLHTGVWHQGPDGWGPQYYLQRHLLGDDL
                     LAVELRHGCNGTFSALELAVPYVKCAPHAGGVLITASDNFGTPLIDRWNPGEGMAYLGD
                     GAGAVVLGSSPGFAELLSICTTTFSGMEEVHRAGEPLFPPGATTGTFLDYGARAARFQQ
                     RATDDGTWVQLLLGHQKHNVECVGQALHEAGVDARDIKTVLIHSMPRQAAASYLKILGF
                     SLDRSTWEFSRTTGHLGAGDHLAALYHLLSTGEVGPGDNLLLCGSSPGVTYKAAVIRIL
                     DTAALRNQEARPDGL"
     gene            12575..13705
                     /gene="couN3"
                     /note="proA"
     CDS             12575..13705
                     /codon_start=1
                     /gene="couN3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 333.4; E-value:
                     3e-101)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN3"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="AAG29788.2"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-14, bitscore:
                     45.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 8.1e-27, bitscore:
                     84.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.8e-37, bitscore:
                     119.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFDLSPQQQQRVDHMRAGAGKLPATEPDGIAGKDSWLAAAELGM
                     TGLCLPTEHGGGGLGALDTALCLEAFCAGGADTGLAFGIAAHLLACGTVLADHAGEPVR
                     AELLQGLASGTVVAANAMTEDDAGSDLSRLTTTAVADGDSYVLNGRKSFVSNAPLADVF
                     ITYAATAPSAGYLGMSAFAVPRTLPGLQVGSLLAKMGLNGCAAAQVEFTDCKVPGRYLL
                     GPENQGNSVFQRSMTWERACLPAIYLGAMEGQLAQCVDHARSRKQFGRSIGNFQAISHR
                     LATMKLRLETSRLLLYRACWYLDQGRPAVEAAALAKTAVAEAAVANALDAVQVFGARGC
                     LAADGIGQQLQNAIPLNIFSGTTEMQREVVAKSMGL"
     gene            13824..15329
                     /gene="couN4"
                     /note="proB"
     CDS             13824..15329
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 1e-92.
                     Score: 302.7. Matches aSDomain:
                     nrpspksdomains_couN4_AMP-binding.1"
                     /codon_start=1
                     /gene="couN4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     324.1; E-value: 2.1e-98)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN4"
                     /product="acyl-CoA synthetase"
                     /protein_id="AAG29789.1"
                     /sec_met_domain="AMP-binding (E-value: 2.9e-97, bitscore:
                     316.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERRGLHDLLSASAARTPDAPAVVGPAGSMSYGELDERADALAG
                     RLSGQGISKGDRVLIWSPKSANAIAAMQAVLRLGAIYIPVDPLTPPERFLVIARESGAL
                     ALCAPEDLSARVPSPLRDCLACVDLDAAPVPDALPRTPVSTCVEPDDLAYILYTSGSTG
                     TPKGVCISHRSALAFIDWAVAELAPGPQDRFANHSGLSFDLSVLDLYAAFTVGAAVCLI
                     QPEFAYVPEGLVEFLHRERISVWYSVPSALILMLRDGGLLDRPAPGTLRALLFAGEPFP
                     IGPLRALAAWSDARLLNLYGPTETNVCTYHEVRPADLARDLPVPIGKPCSGDRVWAIRA
                     DGSEAEPGEEGELVVSGPTVFAGYWGRQPQEGPYATGDRVKVRPDGSFDYLGRRDGMVK
                     IRGHRIELGDVVAALYSHQGVAEAAVIAVGDGLDRVLAAFVVRSRGSAFGNVALRRHLA
                     GRLAPHMIPGDIRFVDRLPHNDRGKLDLAALQRPLHGPQKVQG"
     aSDomain        13860..15026
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couN4_AMP-binding.1"
                     /evalue="1.00E-92"
                     /label="couN4_AMP-binding.1"
                     /locus_tag="couN4"
                     /protein_end="401"
                     /protein_start="12"
                     /score="302.7"
                     /tool="antismash"
                     /translation="ASAARTPDAPAVVGPAGSMSYGELDERADALAGRLSGQGISKGDR
                     VLIWSPKSANAIAAMQAVLRLGAIYIPVDPLTPPERFLVIARESGALALCAPEDLSARV
                     PSPLRDCLACVDLDAAPVPDALPRTPVSTCVEPDDLAYILYTSGSTGTPKGVCISHRSA
                     LAFIDWAVAELAPGPQDRFANHSGLSFDLSVLDLYAAFTVGAAVCLIQPEFAYVPEGLV
                     EFLHRERISVWYSVPSALILMLRDGGLLDRPAPGTLRALLFAGEPFPIGPLRALAAWSD
                     ARLLNLYGPTETNVCTYHEVRPADLARDLPVPIGKPCSGDRVWAIRADGSEAEPGEEGE
                     LVVSGPTVFAGYWGRQPQEGPYATGDRVKVRPDGSFDYLGRRDGMVKIR"
     CDS_motif       14043..14081
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0001"
                     /evalue="1.20E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="couN4"
                     /protein_end="86"
                     /protein_start="73"
                     /score="9.4"
                     /tool="antismash"
                     /translation="AVLRLGAIYIPVD"
     CDS_motif       14193..14228
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0002"
                     /evalue="3.20E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="couN4"
                     /protein_end="135"
                     /protein_start="123"
                     /score="-0.9"
                     /tool="antismash"
                     /translation="LACVDLDAAPVP"
     CDS_motif       14280..14339
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0003"
                     /evalue="8.90E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="couN4"
                     /protein_end="172"
                     /protein_start="152"
                     /score="33.5"
                     /tool="antismash"
                     /translation="AYILYTSGSTGTPKGVCISH"
     CDS_motif       14454..14513
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0004"
                     /evalue="9.00E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="couN4"
                     /protein_end="230"
                     /protein_start="210"
                     /score="-2.2"
                     /tool="antismash"
                     /translation="AAFTVGAAVCLIQPEFAYVP"
     CDS_motif       14862..14927
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0005"
                     /evalue="5.70E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="couN4"
                     /protein_end="368"
                     /protein_start="346"
                     /score="21.9"
                     /tool="antismash"
                     /translation="PGEEGELVVSGPTVFAGYWGRQ"
     CDS_motif       14991..15053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_couN4_0006"
                     /evalue="4.50E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="couN4"
                     /protein_end="410"
                     /protein_start="389"
                     /score="31.6"
                     /tool="antismash"
                     /translation="YLGRRDGMVKIRGHRIELGDV"
     gene            15333..15602
                     /gene="couN5"
                     /note="proC"
     CDS             15333..15602
                     /NRPS_PKS="Domain: PP-binding (18-82). E-value: 1.8e-10.
                     Score: 33.1. Matches aSDomain:
                     nrpspksdomains_couN5_PP-binding.1"
                     /codon_start=1
                     /gene="couN5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to Pseudomonas fluorescens Pf-5 PltL"
                     /product="acyl carrier protein"
                     /protein_id="AAG29790.1"
                     /sec_met_domain="PP-binding (E-value: 1.1e-10, bitscore:
                     33.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTREDISSQLLTFIRESFLAGDPEGELDADTPLLELGILNSL
                     NTAILVAHLGEDYGVHVPLIDVTATTFKSVRTLSELVHESLSRK"
     aSDomain        15387..15578
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couN5_PP-binding.1"
                     /evalue="1.80E-10"
                     /label="couN5_PP-binding.1"
                     /locus_tag="couN5"
                     /protein_end="82"
                     /protein_start="18"
                     /score="33.1"
                     /tool="antismash"
                     /translation="ESFLAGDPEGELDADTPLLELGILNSLNTAILVAHLGEDYGVHVP
                     LIDVTATTFKSVRTLSELV"
     gene            15660..17342
                     /gene="couN6"
                     /note="cumK"
     CDS             15660..17342
                     /codon_start=1
                     /gene="couN6"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 95.3; E-value: 5.6e-29)"
                     /gene_kind="other"
                     /note="CouN6"
                     /product="methyltransferase"
                     /protein_id="AAG29791.2"
                     /transl_table=11
                     /translation="MFLLHAPSVYDFRDRDDILFAYLSDSDSVNVTSVYEMYPIGWFSI
                     KQQLADHDFDCQIVNIASLMLTHPNLDVERLIGRLEAPVFGFDLHWMTQCNGAIELAKA
                     VKRIHPESLIVFGGISATYFARELIRYPQVDVVVQGYDTLAPITQLVEAVVRGGRDFSS
                     IPNLLYKGNDRVETTGFSHKPTSDYNNVRNDWSYYQNTPVTPLSSKLIMTLPNTGCAHD
                     CGWCGGSRFAYRNIMEVDRTLVQKDHDLIVEELKTMGEAARHTSIYALQCYSEGKTRMH
                     AYLDAVRDLGYRSVFFEQFNLTPDDTLKKMGTSTDSYIMLSPESHDPKISKAAGRGTYT
                     MAEMEEWIPRALDAGVKGVMIWFFIGMPYQDKQSVRDTVAYSERLISKFAGSSVLPLIC
                     PMVPFLDPGCRFFEEPEKHGYRIHHRTLEQHRQAMVEPLWYRRLNYETEWLSRREIQDV
                     SYEAIERLVSIKGEHGVLSSVFCDAVLKTIDQTKRLLAEMDHALSLDGRLPATLRDEMR
                     AYNRKILAYSSDQILPIPRPFGGRWFDDVTVPEEMIRELSMTP"
     gene            17391..18236
                     /gene="couN7"
                     /note="cumL"
     CDS             17391..18236
                     /codon_start=1
                     /gene="couN7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036:alpha/beta hydrolase fold protein (Score: 70.7;
                     E-value: 2.7e-21)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouN7"
                     /product="acyltransferase"
                     /protein_id="AAG29792.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3e-13, bitscore:
                     41.9, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.7e-19, bitscore: 60.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANHGPVVYGLEVPGARLHYEIQGAGPLLVVVGLPMGCKGFAPIS
                     RPLAEHFTVVTFDPRGVHSSPADDPNQDALPEVMADDVHRLISALDAGPAYLFASSGGG
                     VTALALAAQHPDQVRTLVAHEPPLLELLTDRVELRAAIDEICDMYRENRPAALQKYLAL
                     ADIRLHRPTPDPPGPNAFTAPWDVWTILDRLFRFTLRPTTRYRPDIDALRPMADRIVIA
                     GGSKAQGSLFHRTAVALADQLGTELVDFPGDHTGFLTDSEPFARLLFEVFTKARSHNGP
                     "
     gene            18586..19278
                     /gene="couO"
                     /note="cumM"
     CDS             18586..19278
                     /codon_start=1
                     /gene="couO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 75.4; E-value:
                     8.4e-23)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouO"
                     /product="methyltransferase"
                     /protein_id="AAG29793.1"
                     /transl_table=11
                     /translation="MKIEPITGSEAEAFHRMGSRAFERYNEFVDLLVGAGIADGQTVVD
                     LCCGSGELEIILTSRFPSLNLVGVDLSEDMVRIARDYAAEQGKELEFRHGDAQSPAGME
                     DLLGKADLVVSRHAFHRLTRLPAGFDTMLRLVKPGGAILNVSFLHLSDFDEPGFRTWVR
                     FLKERPWDAEMQVAWALAHYYAPRLQDYRDALAQAADETPVSEQRIWVDDQGYGVATVK
                     CFARRAAA"
     gene            19678..20508
                     /gene="couP"
                     /note="cumN"
     CDS             19678..20508
                     /codon_start=1
                     /gene="couP"
                     /note="CouP"
                     /product="O-methyltransferase"
                     /protein_id="AAG29794.1"
                     /transl_table=11
                     /translation="MEVAPIVSRVAHKLRSQPEETTQGTGSDSSLYLDLMIKVLAGTVY
                     EDPAHRENFSHRDSTYREEVRSEGRDWPANAHTMIGIKRLENIRQCVEDVIGNNVPGDL
                     VETGVWRGGACIFMRGILRAHDVRDRTVWVADSFQGIPDVGEDGHAGDRKMALHRRNAV
                     LAVSEDEVRRNFRNYDLLDEQVRFLPGWFKDTLPTAPIDALAVLRMDGDLYESTWDTLT
                     NLYPKVSVGGYVIVDDYLMCPPCKDAVDEYRARFGIADELIRIDRDGVYWQRTE"
     gene            20605..22029
                     /gene="couR1"
                     /note="cumO"
     CDS             20605..22029
                     /codon_start=1
                     /gene="couR1"
                     /note="CouR1"
                     /product="tryptophan synthase b-subunit-like\nPLP-dependent
                     enzyme"
                     /protein_id="AAG29795.1"
                     /transl_table=11
                     /translation="MCTHSEHRSVQGSAATGVLHRVPNSLSFYYQHLLVASERIDTTWA
                     STDSWFEPSWQLPKLGPELDEFFSVSGISAGELGEYRGRRLHFLDLTENPGTHTTKTFG
                     SSVIVARAVRHTELTGEPVLLVTPSAANKAVALRNAVLRAYQVGLSDPSKLRVVTVVPS
                     SSLPKLWASDIDADPALRAANPMGVYSGPEREHVKEITTAAVGDLAADDPVLRGFRVWY
                     TLNPKNYMVADFIRTLFEYEYFPPVGERWHTHAVSSAYGFLGHDLGRQMAAEDGVRFDV
                     PQRYLLVQHLETPDLVSAVTGIDVETVVRDLYRATGDGLLTRPADADPRLPEYCYSTGE
                     RLERTFYTRNPPTTKAVRQLVADHGGNGIVVSLPECVNRYAFVRDLLRGADFHRLPEDP
                     RRLREWAMVMSAVGCLNAIDRDLIPAGADVVIHGSGAYSEGEFHQIDRSRLIEVNTPDE
                     VRALISGAIQADGERG"
     gene            22029..22547
                     /gene="couR2a"
                     /note="couR2; cumP"
     CDS             22029..22547
                     /codon_start=1
                     /gene="couR2a"
                     /note="CouR2a; similar to phosphonopyruvate decarboxylases"
                     /product="decarboxylase subunit"
                     /protein_id="AEO99210.1"
                     /transl_table=11
                     /translation="MSTAVVKPAEDVAGRLARILTTGRSGPFLGTPCGVLAQLYREIDA
                     ACGMRTIAREDSAVGVAAGAALAGRQPVVLMQNSGFGQSVNAFASLIMPCRLDVVTVIS
                     VRGMAPDNTEENSAMGTLTPTILAGLNADVRWLADGADLTEATANWLATEVDEPRFLLI
                     APGLFGWRP"
     gene            22544..23161
                     /gene="couR2b"
                     /note="couR2; cumP"
     CDS             22544..23161
                     /codon_start=1
                     /gene="couR2b"
                     /note="CouR2b; similar to phosphonopyruvate decarboxylase"
                     /product="decarboxylase subunit"
                     /protein_id="AEO99211.1"
                     /transl_table=11
                     /translation="MTIRTMTHSPQNKAAAIAEIIGASGDTPIVFTTGYACRIANDIQD
                     KPGHFYMLGSMGLAGCVAVGVAAGLSRPVIVVDGDGSLAMNPGVLLLAAEFTGLPLIHV
                     VLDDRAYSSTGAQPTPPVGNIESWAASLGYLVLSPPLAGGVGSVVAGLLAGELTRPHLL
                     RLPVAPDGRNVPGRIEGRLSGYAARFRTHCRGLRAGSELPVV"
     gene            23194..24102
                     /gene="couR3"
                     /note="cumQ"
     CDS             23194..24102
                     /codon_start=1
                     /gene="couR3"
                     /note="similar to Salmonella enterica serovar Typhimurium
                     PduX"
                     /product="threonine kinase"
                     /protein_id="AAG29797.1"
                     /transl_table=11
                     /translation="MQPVESGRGRAVGTCGELVQGTVDGRELMVTFPVDWYSDVVVRGS
                     YLPGVRVWPRSKVKVRRMCDVLLDRLVGASSADVGLDVLVSSMIPEGRGHASSSADLTA
                     LCRAMAQWLGVPLADDDIMRLCCELEPSDAVCRPVPTLFDFIRGEVLLCYDDPPPMAAL
                     VLDEGGAVDTVTMRRLPCTEAESERLALAFDLVDRGFRLGDLALIGRAAMISAEVNQRR
                     VYKRNFEVARDVADACGSYGVSVAHSGTTLALLFDQHEVEGIRAAHAALRTVAADCELF
                     LLNAVVPTRRAAPDLTELPTR"
     gene            24157..25326
                     /gene="couR4"
                     /note="cumR"
     CDS             24157..25326
                     /codon_start=1
                     /gene="couR4"
                     /note="CouR4; similar to lactate and L(+)-mandelate
                     dehydrogenases"
                     /product="FMN-dependent dehydrogenases"
                     /protein_id="AAG29798.1"
                     /transl_table=11
                     /translation="MGAIRFALPKQGRPISIAGYRTAARRVLPDLVWAYVENGADDSVT
                     LAANRSAFARWSLRQRVLRSSAGRKTAARFGDTELAIPVMIAPTGINGLVHWRGELATA
                     CGAAAAGSRIVLSTAASYSVEEVAAASPVGHWLQVYPWRDRELMDWLLERGRRSDCPTL
                     VVTVDTPVFGNREPERLQGMSIPPVLTPRHVLDAALHPRWAYKVLRHQRVFTGNLVGMS
                     GVRAGALAAKVRRERMMAGELDWDDFARVRAQWQGLCYVKGILDADDAERAVSLGADGI
                     IVSNHGGRQLDGAPATLDALPGIADRLAHRATVLIDGGIRRGTDVVKALCLGADGCLIG
                     RPALYGLAVGGESGVEHVLSILREEIDRTLALMGCSDIADLGRDWLIPG"
     gene            complement(25380..26855)
                     /gene="couR5"
                     /note="cumS"
     CDS             complement(25380..26855)
                     /codon_start=1
                     /gene="couR5"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 309; E-value:
                     7e-94)"
                     /gene_kind="transport"
                     /note="CouR5; transporter"
                     /product="putative resistance protein, transporter"
                     /protein_id="AAG29799.1"
                     /transl_table=11
                     /translation="MTETDVAEPVQAGRWAAYSVCLLAGFVTLLDVSVINVAVPSMQAG
                     LHLSAGQVLWAAFGYTLTFGVVLVPAGALGDQLGRRRTLLVGLAFFAFGSLACGLAASG
                     WWLVAARLVQGLAAGVVTPQVVGLMRQLFARGPELGKAGGAYSGMIAATTAIGPLVGGL
                     LIQAGGPADGWRWVFLVNVPIAALSLPLGLRWLPRDRQQIRGVRLDLLGIALLGSGVAT
                     LILPLIAAEQRQPSVPWHLLGLSALLLACFIAWQQHCTRSGRPRLVNLAMLRQRDYAIS
                     AFVGMGYFVGFVGIPFMVSLYFQLGLGYSALAAGAVGTPTALGAAISAPLAGRAVHRVG
                     RRLVVIGLAAVALGSAGLIALIGHRAGGLVWLLVAGPLLLAGAGSGLVIGPNLTLALQT
                     VPLTEGSAAGAVLQTGQRIGSTIGIAVIGALYFGSLTAHPGDHLRAATDGLLGSTVAIT
                     ITLLITVIALLATRDRRPSTQHGTPATDGDEPD"
     gene            26990..27865
                     /gene="couR6"
                     /note="cumT"
     CDS             26990..27865
                     /codon_start=1
                     /gene="couR6"
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 184.4; E-value: 4.7e-56)"
                     /gene_kind="regulatory"
                     /note="CouR6"
                     /product="regulatory protein"
                     /protein_id="AAG29800.2"
                     /transl_table=11
                     /translation="MVEVRQLRYFVAVAECEHFGRAAETLHIVQAAVSKQVARLERELG
                     LTLFDRSHRRVRLTPDGQAFLAHARRALRGLDRAAAAAADLAAGNTGLLRIGSSIGLGP
                     RVDAALAAVRSAYPGITLQVTTSASTTGHLAAVADYDLDAAFVAAPQATPGVQVHHLWD
                     EPLLLAVPAARAGSAGDLATLAELPLARYARADSPGTDDLITAACRAAGFTPRKGPTLT
                     RAQDLLTGPVSAGDCWAVLAADLLHHVPAAVALVPPVPPVLVPTALALPDPVRRAVVLN
                     LLTVAQAGTV"
     gene            28119..28985
                     /gene="couS"
                     /note="cumU"
     CDS             28119..28985
                     /NRPS_PKS="Domain: NAD_binding_4 (54-156). E-value:
                     5.7e-10. Score: 30.5. Matches aSDomain:
                     nrpspksdomains_couS_NAD_binding_4.1"
                     /codon_start=1
                     /gene="couS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 87.2;
                     E-value: 2.3e-26)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouS"
                     /product="dTDP-4-keto-6-deoxyhexose reductase"
                     /protein_id="AAG29801.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.4e-106,
                     bitscore: 346.0, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNRWLVTGAGGMLGRDLVRVLEALNEPVLAATRQDLDITDRFSV
                     RAVVSRYRPTAIVNCAAWTRFHEAETSEAEAHLINGRGARELATICGDRSIRLVHLSTD
                     YVFDGASRRPYAESAATGPINAYGRTKLAGEQAVLELLPDDGTIVRTAWLYGRHGTNFL
                     RKMVRLEQTHKTVDVVDDQWGQPTWSVDLAQQIVALVRHGASGVFHGTSSGETTWYDFA
                     RMIFRLLGADPGRIRPVRSDQIAGGELRPRYTVLGHAAWREVGLTPIRHWSAALERSFP
                     LLADEEW"
     aSDomain        28281..28586
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couS_NAD_binding_4.1"
                     /evalue="5.70E-10"
                     /label="couS_NAD_binding_4.1"
                     /locus_tag="couS"
                     /protein_end="156"
                     /protein_start="54"
                     /score="30.5"
                     /tool="antismash"
                     /translation="TAIVNCAAWTRFHEAETSEAEAHLINGRGARELATICGDRSIRLV
                     HLSTDYVFDGASRRPYAESAATGPINAYGRTKLAGEQAVLELLPDDGTIVRTAWLYG"
     gene            29019..30029
                     /gene="couT"
                     /note="cumV"
     CDS             29019..30029
                     /NRPS_PKS="Domain: NAD_binding_4 (4-180). E-value: 5.7e-17.
                     Score: 53.5. Matches aSDomain:
                     nrpspksdomains_couT_NAD_binding_4.1"
                     /codon_start=1
                     /gene="couT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     326.3; E-value: 3.4e-99)"
                     /gene_kind="biosynthetic-additional"
                     /note="CouT"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="AAG29802.1"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.3e-17, bitscore:
                     53.5, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.2e-19,
                     bitscore: 61.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6e-25, bitscore:
                     78.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLVTGGAGFIGSEFVRATLRGVLPGSSGTQITVLDKLTYSGNE
                     LNLAPIADLETYRFVQGDICDRGLVDDVVAGHDAIVHFAAETHVDRSIEGAASFVRTNA
                     LGTQVLLEAASRHRLGRFVHISTDEVYGSISEGAWTEASPVAPNAPYAAAKAAGDLLAL
                     AWHRTRKLDVVVTRCTNNYGPYQYPEKLIPLFTTNLLDGQQVPVYGDGHNRRQWLHVSD
                     HCRAIQCVLLGGRPGEVYHIGGGTELTNLELTEHILEACGAGWDRVRHVPDRLGHDLRY
                     SLDTTKIRTELGYSPRVAFADGLAETVEWYRTHRGWWEPLKNPDKATGSPTDAGR"
     aSDomain        29031..29558
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_couT_NAD_binding_4.1"
                     /evalue="5.70E-17"
                     /label="couT_NAD_binding_4.1"
                     /locus_tag="couT"
                     /protein_end="180"
                     /protein_start="4"
                     /score="53.5"
                     /tool="antismash"
                     /translation="VTGGAGFIGSEFVRATLRGVLPGSSGTQITVLDKLTYSGNELNLA
                     PIADLETYRFVQGDICDRGLVDDVVAGHDAIVHFAAETHVDRSIEGAASFVRTNALGTQ
                     VLLEAASRHRLGRFVHISTDEVYGSISEGAWTEASPVAPNAPYAAAKAAGDLLALAWHR
                     TRKLDVVVTRCTN"
     gene            30255..31517
                     /gene="couU"
                     /note="cumW"
     CDS             30255..31517
                     /codon_start=1
                     /gene="couU"
                     /note="CouU"
                     /product="C-methyltransferase"
                     /protein_id="AAG29803.1"
                     /transl_table=11
                     /translation="MQDIVRPINECRVCGHNDWLDVVSFGSTPLAGNLLGTEDDPRDET
                     LFPLDVGVCRKCWLMTLRHVIEPNALFGHYRYVASDAGSIIQHMRQLVELCIRWVGLTD
                     RDLVVEFGSNTGAHLELFQQAGMRVVGVDPARNLADIANDRGVTTIPAGFTTEVGQEIT
                     TGHGPARLVFGRQCFAHIHDVHEVLDGVSALLAPDGLFFVEVPYLVELLANNQFDTIFH
                     EHLSYFSLGALCRLFEAHGLRVVDVHTVDVHGGSIVVFAAPATAGYEVRPAVAEMLAEE
                     RSQGIAEESTYQKFAERTERVRAQIRELVRSLVADGKTVAGYGAPTKGSALLTACGLGH
                     QEIRFCSDTTALKQGKLLPGSRVPIWSPEQASDHVPDYYLLLAWNYASEIITKEKSFLE
                     GGGRFIVPIPEPRVISAESAW"
     gene            31576..32466
                     /gene="couV"
                     /note="cumX"
     CDS             31576..32466
                     /codon_start=1
                     /gene="couV"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: SpcDK_cou"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 252.3; E-value:
                     9.4e-77)"
                     /gene_kind="biosynthetic"
                     /note="CouV; glucose-1-phosphate thymidylyltransferase"
                     /product="dTDP-glucose synthase"
                     /protein_id="AAG29804.1"
                     /sec_met_domain="SpcDK_cou (E-value: 1.7e-206, bitscore:
                     674.9, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGILLAGGTGSRLWPVTRAVSKQLIPVFDKPMIYYPLTTLMMAG
                     IREILVITRPEDQRQFRHLLGDGSQLGLCLEYAVQEKPEGIAQAFVLGADFIGDQSVAL
                     VLGDNIFHGAGLGTRLRQYSDPAGGRIFAYVVADPRAYAVVEFDEAGTAVSIEEKPASP
                     KSRYAVPGLYFYDNRVLEVARDLMPSQRGELEITAVNETYLKWGQLRVTTLDRGAAWLD
                     TGTFTSLVQASEYVRVVEERQGLKIGCVEEVAWRCGLIGNDQLRELSRPLLKSGYGRYL
                     LDLLADQELKELKSS"
     gene            32463..33059
                     /gene="couW"
                     /note="cumY"
     CDS             32463..33059
                     /codon_start=1
                     /gene="couW"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /note="CouW"
                     /product="dTDP-4-keto-6-deoxyglucose 3,5-epimerase"
                     /protein_id="AAG29805.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 4.7e-62,
                     bitscore: 199.7, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLRPLGIEGAWEITPKQHADPRGVFLDWYRVDQFAAEVGRPLRL
                     AQANLSVSVRGVVRGVHFADVPPGQAKYVTCVRGALFDVVVDLRVGSPTYGRWEGTRLD
                     DVSRRAVYLSEGIGHGFCAISDEATLCYLSSQTYNPASEHGVHPLDPELAINWPVETPL
                     LSARDQDALLLAEARDWGLLPSYAACQALTALTSQ"
     gene            33611..35644
                     /gene="gyrB-Rc"
     CDS             33611..35644
                     /codon_start=1
                     /gene="gyrB-Rc"
                     /note="GyrB-Rc"
                     /product="resistant DNA gyrase subunit B"
                     /protein_id="AAO47225.2"
                     /transl_table=11
                     /translation="MTTYDTRTATDTRGSEQPGHVGTASYDANAITVLDGLDAVRKRPG
                     MYIGSTGERGLHHLVQELVDNSVDEALAGVADRIDVTVLADGGVRVVDNGRGIPVGMHP
                     VEKRPAVEVVLTVLHAGGKFGGGGYAVSGGLHGVGLSVVNALSTRLSAEIWTDGHRWTQ
                     DYRDGAPTAPLARHEATSRTGTSLTFWADGDIFETTEYSFETLARRHQEMAFLNGGLTL
                     TLTDERSSARATAAVDEADSDPTAKTVSYRYDGGITDFVVHLNARKGEPAHPSVITIAA
                     EDTERLLSAEIALQWNGQYTDSVYSYANAIHTHEGGTHEEGFRTALTTVVNRYAREKRL
                     LRDKDANLSGEDIREGLTAIISVKLGEPQFEGQTKTKLGNTEVRTFVQKIVHEHLADWF
                     DRNPNEAVDIVRKAVQAATARVAARKARDLTRRKGLLETAALPGKLSDCQSNDPATSEI
                     FIVEGDSAGGSAKAGRNPQYQAILPIRGKILNVEKARIDKVLQNQEIQALISAFGTGVH
                     EDFDIAKLRYHKIILMADADVDGQHISTLLLTFLFRFMRPLVEEGHVHLSRPPLYKIKW
                     SREHVEYAYSDRERNTLLERGRRDGRRIRDDSIQRFKGLGEMNAEELRVTTMDPDHRVL
                     GQVTLDDAAFADDLFSVLMGEDVEARRHFIQRNAQDVRFLDI"
     gene            35723..37834
                     /gene="parYR"
     CDS             35723..37834
                     /codon_start=1
                     /gene="parYR"
                     /note="ParYR"
                     /product="resistant type II topoisomerase subunit B"
                     /protein_id="AAO47226.2"
                     /transl_table=11
                     /translation="MSTFPAPAAGSRPQDGSDYTARHLMVLDGLEAVRKRPGMYIGSSD
                     SRGLMHCLWEIIDNSVDEALAGACDHIEVILHDDGSVEVTDNGRGIPVDTEPRTGLSGV
                     ELAYTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDIEVDRHGRTHAISFRRGAP
                     GTYSAPGPDAPFTRAQGLHRTARIPKSRTGTRVRYWADRQIFLKDAKLSLENLHQRARQ
                     TAFLVPGLTIVVRDEYGLGEGGSKGEESFRFDGGISEFCEYLAADKPVCDVLRLTGQGT
                     FKETVPVLDEHGQMTPTEVTRELGVDVALRWGTGYDTTLRSFVNIIATPKGGTHVAGFE
                     QAVAKTMNEVLRAKKLLRVAEDDIVKDDALEGLTAVVTVRLAEPQFEGQTKEVLGTSAA
                     RRIVNTVISRELKAFLTSTKRDAAAQARVVMEKAVAAARTRIAARQHKDAQRRKTALES
                     SSLPAKLADCRSDDVERSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQKSSVT
                     DMLKNAECGAIIQVIGAGSGRTFDIDAARYGKIIMMTDADVDGSHIRTLLLTLFHRYMR
                     PMVESGRVFAAVPPLHRIELVQPKKGQDRYVYTYSDRELRDRLMEFQSKGVRYKDSIQR
                     YKGLGEMDADQLAETTMDPRHRTLRRINLSDLEAAEQVFDLLMGNDVAPRKEFISSSAA
                     TLDRSRIDI"
ORIGIN
        1 gtggttgcgt ctggtcagac agcttcgaag gctggggggt ccggcgccac tccggtgaga
       61 ccgactgcag gggacgcgac ccccgttgac agcaggaaat caagccacgc ctcttgtctt
      121 ggtgtggagg tttcggccga gaggaccagg cttcagatcc cgcaagatct ctccctggag
      181 gcatggtgcc gcctcggcgg aaggatcctc acggtgtgcg attcgtcggc ctggtggatc
      241 ggtgattggt tggtgttcgg gcagaaccag tatggtgacc gataccgccg ggcgatggag
      301 aagaccaagc tcgactacca gacgctgcga aattacgcct gggtggcgag aaaattcgag
      361 ccgtcccgcc ggcgagacag actcacgttc caacatcaca tggaagtggc atctctctcg
      421 caagccgaac aggatcactg gctcgacttc gcggttcgac tgaactggtc caggaaccag
      481 ctgcgcaaac agatccgggc cagcatatcg ggcgaagaag atgatctgcg gcgccatgtt
      541 cagctcagcc ttcaattaga cgagttacgt ctcgaacggt ggagggaggc ggcgcggggg
      601 agcaatctga ctctgacgga ctggatctta ttcgtcgtcg acgaggccat ttgaccggat
      661 gcgcccatgc gatgtcggtg cccgacgaca ctgctgcgtg gcggccccga agggattgcg
      721 ggagatcaat gcgcacggcc gagggaccgt cgggagcggt ggacctggcg gtggtcgccg
      781 tgccaccggg ccaggtgaca ccggtggtcg cgtctcaccg gtcaagggga gccgctcgct
      841 cctccgtcga cgtggcggga gtgaaggtct cgcgctggcg tgaacgggaa gtactgggtt
      901 gtgaccttgc ccctgtggtg ggtggtcatc cacgggtggg acggccggga gccggttccc
      961 tcacggcgca ggatgacctg cggaaagcga cctgacgggc ctgttggaga cactcggagc
     1021 tgtcgcgggc ggcggcggct cgcccgcgga gtccgacggt catctgctga agttcgtcca
     1081 gcgtcgcatc gatggctgca accgcgttcc cggcaggtac gggattgcca cggagaccgc
     1141 actcgcgggc atcgatgttt ccgtcggcga ccggccgacg gagccggccc gccccgtcag
     1201 cgacgtggcc ggcgccgggg tggggatgca cggcagcaac atctcgcagc ggctgcacag
     1261 cctcgacctc acggtcacca tttccgtcac tccgtgcaac gccgaggacc tcttgcacga
     1321 actacgtcgt aggaagtggc cggcggacgc ctgacatcgg ggagggcggt caactcgacc
     1381 gaactcctcg aatccggcct tccgttcacc atgcggcacg cccttctcgg tgagcactcg
     1441 cgcaacaccg gcgtcgccgg gccgcaccgg cgcgcgaaga actcgacatg cacggcgccg
     1501 atgacctcca gggcgccgat gtcggtggct tagaatcgaa ggggggcagt cggggatggg
     1561 ctcaccgtca accactcaca ggccgcgccg ggtagagccg acgattccgc acaccgtgcg
     1621 aatgttcata cgtcaggcgt ggccgtgatc gatctggacg cggaccgaat tgagctattc
     1681 gggcaatcgt tgtaacgagc gatgaacgtg atttgatgct gctgagcctg gccaagacct
     1741 gcgtctggtc acccatgtcc tacacgcgct gatccaagcc agatcattat gtcctagggg
     1801 gggtcatatg agtaacagcg gtgatgagga gatgacgtcg attctaccta aagcaatcgg
     1861 aaaaggggaa cgggttccga tcggttcgtt gtttccgtcg caacaactac tgcggtccgg
     1921 tgaaagtacg gaacacattc gtgcactggt cgaaacggaa gaggtcctgc cgccgattgt
     1981 cgtgcaccgt gagacacggc gggtcatcga cggaatgcac agactgcggg cagctcgttt
     2041 tcgtggcgac gaatggatcg aggtcgtttt catcgatgac gcctcagccg atgtgtttgt
     2101 cctcgcggtt gagttgaatc gtgcgcacgg cctgccgttg acgatggctg agcgcaaatc
     2161 tgccgccgcg cggatcatgg attcgcaccc gcactggtcc gaccgcaaga tcgcacgtac
     2221 cactggactg gcggccagca ctgtcgcgtc tctgagatcg cactccatcg ctggcacgct
     2281 cgagcgtaga accgggcagg atggccggac tcggcccaag gacggcacgg aaggacgccg
     2341 gcgtgcgagc gagctgctgg cccagaaccc gaacgcgtcg gttcgcgaag tagccaaagc
     2401 ggcgcggatc tcggtgggca ccgccagcaa tgtgcgcgcg agactgcggc gaggcgagcc
     2461 ggccataacc gccctgcagc aggcagccct gacaccacgc ccggcctcgg cgacgcagcg
     2521 aaccggtccg gactacagcc gcgtgctgca gagcctgcgc aacaacccat cgctgcggtt
     2581 caacgacgtc ggccgacact tgctccgctt gcttggcggc gccgccccgg gcagcgtcga
     2641 gcagattgcc cagatcgcgg acagtgtgcc ggaacactgt cgggtcatgg tgatcgacat
     2701 ggcccgcgag tgcgccgccg catggcaaca tctggccgac cggctcgcgg gccgagacac
     2761 cgcctgacgg agacgtaccg tccgatccgg ccgctgcggg acgttcaact gctcgaacca
     2821 tacggttgaa cgccaccaca cagtcgaacg tcgacggtcg gcatcctggt gaccaggccg
     2881 ggcctggaat gttgaaccgc cccggtgcga tgaagacgat ggagagatgg ctcggtctcc
     2941 gaggcactct cgtgaggtac gtgaacgtgc cgtggcggtg gtgttcgaga aggcagatga
     3001 gtattctccg caacacgttt tcgaggtcgc ggcagtccgg tacacctgcc tgcaggaccg
     3061 acaggtcggt tctccagcga tgagatctac ggaggcgcat gtaatggcga cgaacccgtt
     3121 cgatgacgag aacggcgtct atctgctcct ggtcaatgac gaggggcagc attctctgtg
     3181 gccttcgttc gctgctcttc ccaaggggtg gaccgtcatt ctcgatgagg cgtcgcggca
     3241 agagtgcctc gattacgtca acgagcattg gacggacatg cgaccgttga gcctgcagcc
     3301 ggcgatgggt gacgagtaga aaccgctcgt ttcagcgatc aacaacatca agcccaccga
     3361 cagcacccat tcaacctctg tggctgtcca agatgttcaa ggagtcaggc gcttcacggc
     3421 agacccaggg cgtgattcca tcacgcgagg cgttcgatgc atgacttccc agcgcttgga
     3481 gtgtcgtcga gattgatatc gagcaagctg tctcggaagt cacctgttcg tgcagcattt
     3541 cttttcggct atctggggag tatgttccga tggcatggag acttaacggc ggtacaacga
     3601 tgctgatatt caacaggggg cggtttgttc tccaagggtc tgaacaaggc ttctgatcgg
     3661 tcggcgacaa cgaggacggc atcggccacg ctggccgaac tgtgggagcg gacggtacgc
     3721 agtcggccaa gcagtccggc gattgtctcg aacagcgaga ccctgtccta cgacgaggtg
     3781 aacgccaggg cgaaccagct ggcccgactg ctgctcagcg agggggcggg cccgggccgg
     3841 gtggtggcac tggcgctgcc ccgatccagt cgaatggtga tcagcgtgct tgccgtggcc
     3901 aaggccgggg cggcgttcct gccggtggac gtcaactacc cggagcagcg gatcgcctac
     3961 atgctcgctg acgccgagcc cgcattgctg tgcaccatcc ggaccgcagt ccctaagctg
     4021 cctgctgaca tcggggtgcc gcagctggtg ctggactcgg ccgagcagac tgccacgctc
     4081 gacgcactgc ccgacaccga cgtgactgag gacgaacggg gtggttcact cgccgcgacc
     4141 aacctggctt acgtgattta cacctcgggc tcgacaggtc ggccgaaagg tgtcgctctg
     4201 accggtgccg ggttgcccgc cttggccgcg gccaaggtcg ccacgatgca ggtcactgag
     4261 gacagtcggg tgctccagtt cgcctcgccg agcttcgacg cctatgtgac cgagctgctg
     4321 gccactttta cctccggtgc cactttggtg gtgccagggt cggacacact ggtcggcgac
     4381 ccgctggcaa aggtcctacg ggagggccag gtcagccacg cggtgctgcc gcctgccgca
     4441 gtcgcgacca tgtccccgga cgcggcgccg gacctgcgcg tgctggtggt ggccggcgag
     4501 gagtgcccgg ccggcctggt ggaacagtgg tcaccaggac gccttttggt caacgcctac
     4561 ggtccgaccg agtgcaccgt gtgcgcgacc atgaccggcc cgctgacccc gacggacgag
     4621 gtcactattg gccggccgat tcctggcgtg tctgtgcaca tcctcgacga cgaactacta
     4681 ccggtcgcgg ccggagaaat cggcgagttg tacctcagcg gtgccgggct tgcgcgcggc
     4741 tacctcaacc gccctgatgt gaccgcgcat gtgttcgtgg ccaatccctt cgccgccgac
     4801 ggcgaacgga tgtaccgcac cggtgatctg gcctccatgc gggccgacgg cgacatcctg
     4861 ttccacggcc ggatcgacga ccaggtcgaa ctgcgcggat tccgaatcga gctcggagag
     4921 gtggagtccg tgctcagcca acatccggac gtggcgcagg cggtggccgt gctgcgggcc
     4981 ggcgaagacg acgggccgca gctgctggcc tacgtggtgc cgacgcacgg caccacgccc
     5041 gcggcaggcg aactgcgtga gcacgccggc cgctacctgc ccgactacat ggtgccgtcg
     5101 gtctatgcga ccatcgacgc cattcctgtg actcccagcg gaaagacgga ccgagccgcg
     5161 ctgccgccga tcaagaccac caggcccgcc ggtcagaaac cgcgcacttc cgccgagaag
     5221 atccttttcg atatcttccg ggacctgttc ggccttggtg agatcgacgt gcgcagtaac
     5281 tttttcgaaa tgggcgggaa cagcatcctg gctgtcgacc tcattcagcg agcgcaggaa
     5341 gccggcttgg tgctcttgcc gaggaccgtg atcgaccacc cgaccatcga gcagctggcc
     5401 gcgatagcga acctcgggga gtgagagatg agcacccgtc ccatggtgtc cgccgacgaa
     5461 ctcgaggaca tcgacctggc gtcgcccatt ctgcacgccg agtacgagct cgatgcggtc
     5521 ttccgtcatc tgcgggccaa tcggccgatg tactggcagc agccacgggg tgagcagccc
     5581 ggcttctggg tgatcagccg gtatgccgac gtgaacgagg tgtacaagga caaggcgcac
     5641 ttcaccacgg agaacggtaa cgcgctggcc accttgctca ccggcggtga ctcggcctcg
     5701 ggtgccatgc tcgcggtcac cgacggtgtg cgccaccacc aggtgcgcaa cctgttgtcc
     5761 aagggctttt cgccgcagat gctcgaactg atcgccaact cgctgcggga aaccgttgac
     5821 gggctgctgc tggccgcgct ggatcgaggc gaatgcgatg ccgcacggga catttcggcg
     5881 aaagtgccgc tgggcgccat ctgtgacctg ttggaaattc cccagaccga ccgggaatac
     5941 ttgctcggct tgaccgcgca cgcgtggagc acggactacg cggacgaacc tcctgaggag
     6001 agctgggtcg ccaagaacga gatcctcctg tatttcagta aactgctcaa ggagcgtcgt
     6061 ggtggtgacc gggacgacat ggtcagcctg ttggcgaatt gccggatcga cggccatccg
     6121 ctcaatgcgg ccgagcagat agccaactgc tacgggctga tgatcggcgg cgacgagacc
     6181 ggcagacacg ccatcaccgg cacggtcctc gcgttgatcg agaatcccga ccaatggcga
     6241 gccctgaaga atggcgatgt cgatctgaag acggcgaccg aggaggcact gcggtggacc
     6301 gtgccctcgc tgcacggtgg ccggaaggca accggagacg ttgtgatcaa cggccagcag
     6361 atcaaggccg gcgaggtggt cagcgtgtgg atctcctcag ccaaccggga tgagaccgtc
     6421 ttcgacgcgg cggacgagtt caagctcgcc cgcaccccga acaagcactt caccttcgcc
     6481 tacggctcgc actactgcct cggccactac ctcggccgga tggaggtcta cgccgtgctc
     6541 gacggattac gccggctggt gggcgacctg gagcagatcg gcgaagagcg gtggatctac
     6601 tccagcatcc tgcacggcat gagctcactg cccatcaaga tcacggcctg aagccccccg
     6661 ggggacgtgc acatgatgag caccgtcaac gcggccaacg cattcgagga cgggccaggc
     6721 gccgagttct cctcggatcg cccgacagcc cgcccttgcg tacatcgagc ggaatggggc
     6781 ggcgcgccga ccgcggagcg cgacccggtg atgactgggc ccgccgcatc agcggtggct
     6841 tgcgagccgg tcgcgatggt caccggagcc ggccggggca tcggcgctgc cacggccgag
     6901 cgccttgccg cggagggcat ggcggtgatc gtcgtggacc gcgtggaaca ggacaccaca
     6961 gccaccgtct cggccatccg tgcggccggc ggacgggcca gcgggctcgg ctgtgacgtc
     7021 tccgtagctc aggcggtgac ggccaccgtc gcctcggccg tcgaggagtt cggtcacctc
     7081 gacgtgctgg tgaactgcgc cgggatcacc caggatcggc tgctgctcac catgagcgac
     7141 caggagtggg acagggtcct ggacgtcaac ctcggcggca gcatgcgatg ttcgttcgcg
     7201 gtcgggaggc acatgcgccg gcaggggcac ggccggatca tcaacttcag ttctgttgcc
     7261 gcgcgcggca atgccggtca gaccaactat gcgaccgcga agggcgcgat tgccgggttc
     7321 acccgcacgc tcgcggccga attcggtccg cacggcgtga cggtcaactc gatcgcaccg
     7381 ggcttcgtgg ccacgccgat ggtggcagag ctgaccgaac ggctcggcgt ggatcgggac
     7441 accgtcctgc tggaggcggc gatgtcctcg gccgtgggcc ggatcgggac gcccgaggaa
     7501 atcgccgcgg tggtggcatt cgtcacccgg ccggaatcgg gctacctcac cggggagacc
     7561 atccacgtcg aaggtggtcg gcgatgacgg gagtcgcggt cgtggccggc ggcggcgagc
     7621 acacggggcc cgcggtcgcg gtcaggttgg cggggcgggg cttcgatgtc gccctgctgg
     7681 acaccgagtt cacggcggcc gacaaaactg tcaggcagat cgaggagtcc ggcaggcggt
     7741 gcgtcacggt ggaggccgag ttgaccgaca ccaggtcggt cggtgccgct ttcggccagg
     7801 tgcgtagcgc gctgagcagc cccgtcgtgc tggtcacctg cgtcggaccg gggccggtgc
     7861 cggacgggtc acccgaggac gaactcgcgg acgaacagcg ctatggcgtg gtccgacggg
     7921 cgctgcgctc ggcgttcgta tgttgccagg ccggggccgg ccacctactg catcaccggt
     7981 ggggacggat catcatcgtc accgagccgg tcgacgcggg cggaaacgcc tggcgcacct
     8041 cccagcccgt gctggccggg ttgatcggtt tcacccggtc cgcggcgctg gagctggcga
     8101 ggtccggtat caccgtgaac ctcatcgcgc cggccgagag cgcggtcgac agccgggccc
     8161 cggcgcacca accggcggtc aacgtcggcg cgggctccta cgcggagggg gtcgcgcacg
     8221 tgacggcgtt tctgatcgac gatcaggccg tcggaatcac cgggcaggag atatacctcg
     8281 ccgctgccca agcgggagtg cctctacttc gcgaaaggta gtcactggtg gcgaacaggg
     8341 accacgggcc ggagcactac gtcacccgca tcctcgatga ggcggcccgg gacggcgcgc
     8401 gaccggttgt ccggtggcgg gacacggtaa tcaccggcac agagctccac cggtcggtac
     8461 ggcgggtcgc gacggcactg cgcgaggcag gtgtggcacg cgaccacgcg gtggccatcc
     8521 tgacccaggt gaacagccca tggatgctgg tcgtccgcta tgccgcacac ctgctgggcg
     8581 catcggtcgt gtacataacc ggcgccaacc acggcaccgt gacccacgac ctgccggtca
     8641 ccacccgggt ccggatgatg cgtgaagcag gcgcatctgt actggtgttc gatgagcgca
     8701 acgctcagct cgccgagacc atccgcgaga cggttccgga caaactcgtg ctgtgcggcc
     8761 tcggccatcc ggcgtccggc acggtgaccg ccgacggccg gccggtcgag gacgtggcgg
     8821 tggaattccc ggccgagaca cctgagctgg caatggtgct ctataccagc ggtaccaccg
     8881 gtcaacccaa gggggtgtgc aaaccgttcg gggcgtggaa cgcgaccgtg gtcggcctgg
     8941 ccgggcaacc ccggccgcgg cagacctatc tggcgatgac cgccgtgagc cacacagtgg
     9001 gaatggtcgt cgacatagcg ctggccgccg gcggcagcgt gctgctgcgt gagaagttcg
     9061 atcccaccga cttcctgcga gatgtcgtga cgcacagggt caccgacacg ttcatgggtg
     9121 tgccgcagct ctacgcgatc ctcaatcatc ccgatgttcg caccacggac ctgtcctcgc
     9181 tgcaacacct ggtgtacgtc ggctgtcccg catcgccgga acgcctgcgg gaggcggtca
     9241 ctgtgtttcc cggtgtgctg tggcagtcct acggttccac cgagaccggc cggatcgcga
     9301 tgctccgtga ggacgaccac gaccatcctg aactgctggc caccgtgggc cggccgatgc
     9361 cgggggtcac catcgcgatc cgcgacccgc aaacaggacg agacctgccg gtcaacgaga
     9421 tcggcgaggt ggtggtgcac agcccgaaca acatggccgg ctacatcggc gatcccgagg
     9481 gcaccacgcg ggtggtccga gacggctggg tgcataccgg cgacatgggc tccgtcgacg
     9541 aacgcgggta cgtgcggctg ttcggccgga tgcacgagat ggtcaaagtg caggacacgc
     9601 gagtcagtcc gaccgaggtg gagaaggtgc tcgtcggctg tcccggcgtg gtggatgcgt
     9661 gcgtgtacgg ccaccgcagg ccggacctga tcgaggaact gcacgccgcc gtcgtgctca
     9721 gtaccgagga cgccccgagt ttcgccgctc tgcgcgacca cgtcgcgcag accatgaccc
     9781 cgacgcacgc tccggtccgg ttcgtgcgct ggcggcagtt cccgatcaac aacaccggga
     9841 agacggatcg gctgcggatc cgcgaggtca gcgccgaggc tcgcggtgag ggcccggacg
     9901 tgctggtgga caggtgaggt gagtcattcg atgagagtgc tgttcacgag cctgcccggt
     9961 atcggccacc tgtttcccat ggtgccgctc gcctgggcgc tgcaggcagc agggcacacc
    10021 gtgctggtcg ccaccgaccg tgagttcctc ccggtggtga ccggagccgg actgcctgcc
    10081 gcggccgtgc gggaccctgt tgacccggtc gagctgttca aaccggtcag cctgtccggc
    10141 ctgtccggcc tgctcggctt gtccggcggt ccggtgagcc cggctgagag gaccggccac
    10201 cggtgtgccg agatcggtgt ccgagcgctg gccgccgtcc gtgcactcgt cgacgcatgg
    10261 cgcccggacc tggtgattgc cgaacccatg gagctggccg ggcctgccgc ggcgacgatc
    10321 gcgggcgtgc cctgggtgcg gcactcctac ggcctgatcc caccggagcg actgctgagc
    10381 gccgcggccg cggccctgga ctcagaactg gcggtacgcg ggctgtcccc gtgggcagag
    10441 ccggccggca cgatcgacgt gtgccccgac agcctccagc cttcggatgc ggtggcgacc
    10501 atgcccatgc ccatgcggta tgtgccctac aacggcccgg ccgtcgtgcc cgactggcta
    10561 ctggccgggc cgtcgccacg gccccgggta tgcctgacct tgggcacgtc cctgcctcgg
    10621 cgcaatccgc gggtcgcacc gctgtggcgg ctgctgctgg acgaactggt ggcgctgggc
    10681 caagaggtgg tcatcgccat cgacgagagc caccggtcgc tgctgggtca cttgcctggc
    10741 ggcgtgcgtg cggcgaggat cccgctgtgt gacctgctgc cgacctgcac cgcgatcgtg
    10801 catcacggtg gctccgggag caccatggcg gcggcggcgt tcggcgtgcc gcaactggtc
    10861 gtcccgcact tcgccgacca cttcgccaat gcggagcgga tcatcgcggt cggcgcgggc
    10921 acgagcctgc cgcacgacac cgatgacctg gcgcggatca cagcagcctg cgcgctgatc
    10981 gtcgatgacg gcccgcaccg ggcgatctca gcacgactcg ccgaagagaa cgcgagccga
    11041 ccgaaaccga ccgaggtggc ccaggacctg gtggccctgg tcctcgagca cagccaggat
    11101 gtcctgcgac cgcagcacgc gtcgcagggt cgacagtagg caggactgct gcggatgtcg
    11161 tgctggcact gtcttgcgac tcttctccgc ggcaacacaa tcgacgggaa ctacgcgaca
    11221 tggtcactgg acgcaccgag ctcgagcacg tccttactcg cctggaaatg ctgctgaacg
    11281 acgtctggga ccagcggccg gcgggggtgg cgatgtctgc caccgcaccg ctggtgagcc
    11341 tcggggtgga ctcgctcacg ctcgcgctgc tcctcgacaa cgtgggcagg gaattccaca
    11401 tcgactggac ggccgatacc cgtctgggcg gagcgatctc gctacgttcc ctcgcggatc
    11461 tcgtcctgcg acgggacggc ggccccgccg ccgctgccga ggcatagggc ccggcccatg
    11521 cggacatcgg gtacgtacct ggccgggatc ggagtcttcc ggcccaagac gaaaagcgtc
    11581 gatgccgcgg tgcggcaggg gctcgtctcg aaggaatctg ctgacgcctc cggaatcacc
    11641 ggcgtgtccg tcgccggtga cgtctctcct gccgagatcg cgttgatcgc cgcacgccaa
    11701 gccctccaca gcagtggact gagcgccgat gacatcggac tgctgctcca caccggggtt
    11761 tggcaccagg gacccgacgg atgggggccg cagtactatc tccagcggca cctgctcggt
    11821 gacgatctgc tcgccgtgga actcaggcat ggctgcaacg ggactttcag cgcactggag
    11881 ttggccgtcc cctacgtgaa atgcgcacct catgccggcg gggtgctgat caccgccagt
    11941 gacaactttg gcaccccgct gatcgacaga tggaaccccg gcgaagggat ggcctacctg
    12001 ggtgacggcg cgggcgcggt ggtgctgggc tcttccccgg ggttcgcgga gctgttgtcc
    12061 atatgcacca ccacgttctc cgggatggag gaggtccacc gggccggtga gccgctcttt
    12121 ccgcccggcg ccaccaccgg tacttttctg gactacggtg ccagagccgc gcgattccag
    12181 cagagggcga ccgatgacgg cacgtgggtg cagctcctcc tgggccacca gaagcacaac
    12241 gtggagtgcg tgggccaggc gctccacgag gccggtgtcg acgcccgcga catcaagacc
    12301 gtcctgatcc acagcatgcc gcgtcaggcg gccgcctcct acctgaagat cctcggtttc
    12361 tcgctggacc gctcgacctg ggagttcagc cggacaaccg gccacctcgg ggccggcgac
    12421 catctcgccg ctctctacca cctgttgtcg acgggcgagg tcggccccgg cgacaacctg
    12481 ctgctgtgcg gttcctcgcc tggcgtcacg tacaaggcgg ccgtgatccg aatcctcgat
    12541 accgccgccc ttcggaacca ggaggctcgg cccgatggac tttgacctca gcccacagca
    12601 gcaacagcgc gtcgaccaca tgcgcgcagg cgccggcaag cttccggcca cggaacccga
    12661 cggaatcgct ggaaaggaca gttggctggc cgcggccgaa ctcggcatga ccggcctgtg
    12721 cctgcccacg gaacatggcg gcggcgggct cggtgctctg gacacggcgc tgtgcctcga
    12781 ggcgttctgc gccggtggcg cggacaccgg cctcgccttc ggcatcgcgg cacatctgct
    12841 tgcctgcggg accgttctgg ccgatcacgc gggcgaaccg gtgcgggccg agctgctcca
    12901 gggactggcc tcgggaactg ttgtcgcggc gaacgcgatg acggaggacg atgcgggatc
    12961 cgacctgagc agactcacca cgacagccgt ggccgacggt gacagctacg tcctgaacgg
    13021 aaggaaatcc ttcgtcagca acgccccgct ggccgacgtc ttcatcacct acgcggccac
    13081 cgcaccgagc gccggttacc tggggatgtc ggcgttcgcg gtcccgcgaa ctttgcccgg
    13141 cctgcaggtc ggttccctgc tggccaagat ggggttgaac ggctgcgccg ccgcgcaggt
    13201 cgagttcact gactgcaagg tccctggccg ctacctgctg ggcccggaga accaggggaa
    13261 cagcgtcttc cagcgctcca tgacctggga acgcgcctgt ctgcccgcga tctacctggg
    13321 tgcgatggag ggtcaactgg cccagtgcgt ggaccatgcc aggagccgca agcagttcgg
    13381 ccgcagcatc gggaacttcc aggcgatctc ccaccggctc gccaccatga aactgaggct
    13441 ggaaaccagc cgcctgcttc tgtaccgcgc gtgctggtac ctcgaccaag gccggccggc
    13501 cgtggaggcg gccgcattgg ccaagacggc agtcgccgag gccgccgtag ccaacgcgct
    13561 ggacgcggtg caggtgttcg gcgcgcgggg gtgtctggca gcagacggaa tcggccagca
    13621 gctgcagaac gccataccgc tgaacatctt ctcagggacg acggagatgc aacgggaggt
    13681 cgtcgcgaag agcatggggt tatgagcggc cggtcgagaa ccggttcagc agatgatctc
    13741 tgacgcccgg accaaagcct ttcgtgccgt caggcgttcc acatgaccaa cccacctttt
    13801 ctactgcacc caggagccga agcatgagtg aaaggcgcgg cctccacgac ctgctgtccg
    13861 cctccgcagc tcgcacgccg gacgctcctg ccgtcgtcgg acccgccggt tcgatgagtt
    13921 acggggaact cgacgaacga gccgacgccc tggccggcag gctgtccggc caaggaatca
    13981 gcaaggggga ccgagtgctg atctggtccc cgaagtccgc caacgcgatc gccgccatgc
    14041 aggcggtctt gcggctcggt gcgatctaca tcccggtcga tcccctcact ccccccgagc
    14101 ggttcctggt gatcgcgcgc gagtccgggg cgctcgccct gtgcgctccg gaggacctgt
    14161 ccgcgcgggt gccaagcccg cttcgcgact gcctcgcgtg tgtcgacctc gacgccgcgc
    14221 cggtgcccga cgctctcccg cgtacaccgg tgagcacgtg cgtcgaacca gacgatctcg
    14281 cctacatcct ctacacctcg ggctcgaccg ggacgccgaa gggcgtctgc atcagccacc
    14341 gcagcgccct ggccttcatc gattgggccg ttgcagaact cgcccccggc ccgcaggacc
    14401 gctttgccaa ccattcgggg ctctcgttcg acctgtccgt cctcgacctc tatgccgcct
    14461 tcaccgtggg ggcggcggtg tgtctgatac agcccgaatt cgcctacgtc ccggaagggc
    14521 tggtcgagtt cctgcaccgc gagcgcatca gtgtgtggta ctccgtgcct tccgcgctga
    14581 tcctcatgct gcgtgacggc ggtctgctcg accggcccgc gcccgggacg ctccgcgcgc
    14641 tgctgttcgc cggcgagccg tttccgatcg gccctcttcg agccctcgcc gcctggtccg
    14701 acgcccggct gctcaatctg tacggaccta ccgagaccaa cgtgtgcacc tatcacgaag
    14761 tccgccccgc ggaccttgcc cgcgacctgc cggtcccgat cgggaagccg tgcagcggcg
    14821 accgggtctg ggctatccgc gccgacggtt cggaagccga acccggtgag gagggcgaac
    14881 tggtcgtcag cgggccgacg gtcttcgctg gttactgggg ccggcagccg caggagggcc
    14941 cgtacgcgac cggcgaccga gtcaaggttc ggccagatgg ttcgttcgat tacctcgggc
    15001 gccgcgacgg catggtgaaa atccgcggac accggatcga actcggagac gtcgtcgcgg
    15061 cgctgtactc ccatcagggg gtcgccgagg ccgctgtcat cgcggtgggc gacgggttgg
    15121 accgggtcct ggccgcgttc gtggtccgaa gccggggaag cgccttcggg aacgtcgcgt
    15181 tgcgccgaca cctggccggc agactcgcac cccacatgat ccccggtgac atccgcttcg
    15241 tcgaccggct gcctcacaac gatcgcggga agctcgacct cgcggctctg cagagaccac
    15301 tccacggccc acagaaagtt caagggtgag aaatggcaac ccagacccga gaagacattt
    15361 cgtcccagct gctcaccttc atccgtgaga gcttcctggc cggggatcct gagggtgagc
    15421 tcgacgcgga taccccgttg ctcgagctcg ggatactcaa ctccctgaac actgccattc
    15481 tggttgcgca tctcggggag gattacggcg tccacgtgcc attgatcgac gtcaccgcca
    15541 ctaccttcaa gtccgtgcgc accctgagtg agcttgtgca tgagagcctg tcgcggaagt
    15601 aaatactgtc gtcccagcca actaatagtc tggatgtcca attgaaattg aacgcggaca
    15661 tgttcctgct gcatgcgccc agcgtgtacg acttccggga ccgtgacgac atcctgttcg
    15721 cctacctgag tgacagcgac agcgtcaacg tcacctccgt atacgagatg taccccatcg
    15781 gctggttctc gatcaagcaa cagctggccg accacgactt cgactgtcag atcgtcaaca
    15841 tcgcctccct gatgttgacg cacccgaatc tcgatgtgga gcgactgatc gggcggttgg
    15901 aagcgccggt cttcggtttc gacctgcact ggatgaccca gtgcaacggt gcgatcgagc
    15961 tggccaaggc ggtgaagcgg attcatcccg agtcgctgat cgtcttcggt ggcatctcgg
    16021 ccacgtactt cgcccgggaa ctcatccggt acccgcaagt ggacgtcgtt gttcagggat
    16081 acgacacgct cgcccccatc acccagctgg tggaggctgt ggtgcggggc ggccgagact
    16141 tcagctcgat acccaacctc ctctacaagg gcaatgaccg ggtggagacc acaggattca
    16201 gccacaaacc cacctcggac tacaacaacg tcaggaatga ctggtcctac taccagaaca
    16261 cgcctgtgac gccgctttcc agcaagctca tcatgacgct gccgaacacc gggtgcgccc
    16321 acgactgcgg ctggtgcggc ggctcccgct tcgcctatcg caacatcatg gaggtggaca
    16381 gaaccctcgt acaaaaggac cacgacctga tcgtcgagga gctcaagacg atgggggagg
    16441 cggccagaca cacctccatc tacgccctcc agtgctactc ggaaggcaag acgaggatgc
    16501 acgcatacct cgacgcagtg cgcgacctcg ggtaccggag tgtcttcttc gagcagttca
    16561 acctgacgcc cgacgacacg ctgaagaaaa tgggcacttc cacggactcg tacatcatgc
    16621 tttcccccga gtcgcacgac ccgaagatca gcaaggctgc cggccgcggc acttacacga
    16681 tggccgagat ggaggaatgg attccacgcg cgttggacgc cggggtcaag ggcgtcatga
    16741 tttggttttt catcggcatg ccgtatcagg acaagcagtc cgtgcgcgac acggttgcct
    16801 actcggagcg cctgatcagc aaattcgcgg gatcttcggt ccttccgctc atctgtccca
    16861 tggtgccctt cctggaccct ggctgccgat tcttcgagga gcccgaaaag cacggctacc
    16921 gaatccatca ccgtacgctg gagcaacacc ggcaggccat ggtcgaaccg ctctggtacc
    16981 gtcggctgaa ctacgagacc gagtggctga gccgacgcga aattcaggat gtctcctacg
    17041 aggcgatcga gcggctggtg agcatcaagg gcgagcacgg tgttttgtcc agcgtgttct
    17101 gcgatgcggt gctgaagacg attgaccaga ccaaacggct cctcgcggag atggatcacg
    17161 ctctctccct ggacggccgg cttcccgcaa ccctgcggga cgaaatgcgc gcttacaacc
    17221 gcaagatcct cgcttattcc agcgaccaga tcctgccgat accccgcccc ttcggcggac
    17281 gctggttcga tgacgtcacg gtgccggagg agatgatccg cgagctctcc atgaccccgt
    17341 gaccccgccg agacagcaca cttctcaaca gcaggaagga ccgactgagc atggcgaacc
    17401 acggaccggt ggtctatggc ctggaagtgc ctggcgcgcg cctgcactac gagatccaag
    17461 gagcaggtcc cctgctcgtc gtggtcggtt tacccatggg ctgtaaaggg ttcgcgccga
    17521 tctcgcggcc gctggccgag cacttcacgg tcgtgacctt cgacccccgt ggggtccaca
    17581 gcagccctgc ggacgacccg aaccaggacg cactccccga ggtgatggcc gacgacgtgc
    17641 accggctcat ttcggcgctc gacgccgggc cggcgtactt gttcgccagc agcggaggcg
    17701 gtgtgaccgc gctcgcgctg gctgcccagc accctgacca ggtcaggacg ctggtcgccc
    17761 acgagccccc gttgctcgag ctgttgaccg accgcgtgga actgcgcgcc gccatcgatg
    17821 agatctgcga catgtaccgt gagaaccgcc ccgcggcgtt gcagaagtac ctcgcccttg
    17881 ccgacatccg cctgcaccgg ccgaccccgg acccgcccgg accgaatgcg ttcaccgccc
    17941 cgtgggacgt gtggaccatc ctcgaccggc tcttccgttt cacccttcgc ccgactaccc
    18001 gctaccggcc tgacatcgac gcgctgcgac ccatggccga ccgaatcgtc atcgccggcg
    18061 gatccaaggc ccagggctcg ctcttccacc gcaccgcggt cgcactcgcc gatcaactcg
    18121 gcaccgaact cgtcgacttt cccggcgacc acaccggctt cctgaccgat tcggagccct
    18181 tcgcccggtt gctgttcgag gtgttcacga aagcgcgctc gcacaacggt ccctaagatc
    18241 cggaaccgac cggcatcacg cccacggaat ccgcgccatc gacgccattc tgtgtgtatt
    18301 tccgttgcac ggaggatcgc aagtggtcgc agatcgccga agtggcatgt aggctcattt
    18361 gaagattttg ctcgccgacg agggcaagaa gttcccgtcc tcgaagctgc gaaccttcca
    18421 caccatcgca tcggcgaggc ctcggcgggc ggcccttgtg gaagagaact ccctaccgcg
    18481 aaccccgcga cgcagcctgc attcgcacgt catcggcgca tcggggccgc tcaccccgcc
    18541 catcgttgag atcagttcac tgacgcagca ccagggggga tcgagatgaa gattgaaccg
    18601 attacgggat cagaggccga agcctttcac cggatgggct cccgggcgtt cgaaaggtac
    18661 aacgagttcg tggacctgct ggtcggcgcc ggcatcgccg atggccagac cgtggtcgac
    18721 ctgtgttgtg gttcggggga gctggagatc atcctcacct cccggttccc atcgctgaac
    18781 ctggtcggcg tcgacctctc ggaggacatg gtccgaattg cccgggacta tgccgccgag
    18841 cagggcaagg agctggagtt ccgtcacggg gacgcgcagt ccccggccgg catggaggat
    18901 ctgctcggaa aagcggatct ggtggtctcg cggcacgcgt tccaccggct cacccggctc
    18961 ccggcggggt tcgacaccat gttgcgcctg gtcaagccag ggggagccat cctcaacgtc
    19021 tccttcctgc atctcagcga cttcgacgag cccgggttcc ggacgtgggt tcggtttctg
    19081 aaggagcggc cttgggacgc ggagatgcag gtcgcctggg cgctggctca ctactacgcg
    19141 ccccggctcc aggactaccg cgatgccctg gcccaggcgg ccgatgagac gccggtgtcc
    19201 gagcagagaa tctgggttga tgaccagggc tacggcgttg ccacggtcaa gtgttttgcc
    19261 cgtcgggccg ctgcctgacc ggccgttcgg tcccgctgct caggatctgg cggacgtttt
    19321 gcccgtgact cgggcgagtt gacgcccgcc acccagatcg ccgcggtgct gccctacgac
    19381 ccgcacacag cacggccgtg gatcgcccgc catgacgtcg aaggagtcat cgggctgccg
    19441 agccggcctc gcagcggccg gccccggctg ggcagtccag ccgggccgac ggatccgtgc
    19501 cctgctcgcc tcgctgaagg cgtggagcgc ccgctcgaga agatgggcgt ccgggaagaa
    19561 ctcgaagacg gcggctacac agagaattat ggcatcgagt cgtcagctac ggattcatcg
    19621 gactcacggc gtaagtgcag taggcggaaa cttctgagcc tcgatacctg gacccgaatg
    19681 gaggtggcac ctatcgtaag cagggtggca cacaaactcc gatctcagcc cgaagaaacc
    19741 acccaaggaa caggcagcga ctcatcgctg tatctggacc tcatgatcaa ggtgttagcc
    19801 gggacggtgt atgaggatcc tgcgcaccgg gaaaacttct cccatcgcga ttcgacgtac
    19861 cgggaagagg tccgcagcga gggacgcgac tggccggcga acgcgcacac gatgatcgga
    19921 atcaaacgcc tcgaaaacat tcggcaatgt gtcgaggacg ttattggcaa caatgtcccc
    19981 ggtgacctcg tggaaactgg ggtgtggcgt gggggagcgt gcatcttcat gcgcggaatt
    20041 ctgcgcgctc acgacgtgcg cgaccggacg gtgtgggtcg ctgactcctt ccagggcatt
    20101 cctgacgtcg gtgaggacgg ccatgccggc gaccggaaga tggcgctgca tcggcgtaat
    20161 gcggtgctcg cggtgtccga ggacgaggtc cggcgcaact tccgcaacta cgatctgctc
    20221 gacgagcagg tccggttcct ccccggctgg ttcaaggaca cgctgcccac cgcgccgatc
    20281 gacgcgctcg ccgtactgcg gatggacggg gacctgtatg aatccacctg ggataccctg
    20341 accaacctct acccgaaggt gtccgtcggt ggctacgtca tcgtggacga ctacctgatg
    20401 tgcccgccgt gcaaagacgc ggtggacgaa taccgtgcgc ggttcggcat cgccgacgag
    20461 ctgatcagga tcgaccgcga cggtgtctac tggcagcgca ccgagtaggt tcacgacgac
    20521 tcgacgcctc gggtatgtgg accacccggg cggaaggcac aagaacacta atcgcggacc
    20581 cggatcagaa tgcggtgacc cgtaatgtgt actcactcag aacatcggtc cgtgcagggc
    20641 tctgcagcca cgggggtatt gcaccgagtc cccaactctc tcagcttcta ttatcagcat
    20701 ctgctcgtgg ccagtgagcg gatcgatacc acctgggcca gtaccgattc ctggttcgaa
    20761 ccgagctggc aacttcccaa actcggcccg gagctggacg agttcttttc ggtcagcggg
    20821 atttccgccg gcgaacttgg cgaataccga ggacgtcggc ttcacttcct cgacctgacc
    20881 gagaacccgg gcacacatac cacgaagacg ttcggctcct cagtgatcgt ggcccgcgcg
    20941 gtacggcata ccgaactgac cggcgagccg gtgctgctgg tgaccccgtc ggcggccaac
    21001 aaggcggtgg cgctgcgcaa cgcggtgcta cgcgcctacc aggtcggcct gtcggacccg
    21061 agcaagctgc gcgtggtcac cgtggtgccg tccagttcac tgcccaaact gtgggcctcc
    21121 gacatcgatg ccgatccggc gctgcgcgcg gccaacccga tgggcgtcta ctccggaccc
    21181 gagcgtgaac acgtcaagga gatcacgacg gccgccgtcg gcgatctggc cgccgacgat
    21241 cccgtcctgc gtggatttcg agtctggtac acgctgaacc cgaagaacta catggtggcc
    21301 gacttcattc ggacactgtt cgagtatgag tacttcccgc ctgtcggtga gcggtggcac
    21361 acccacgccg tctccagcgc ctacggtttt ctcggacacg acctgggccg gcagatggcg
    21421 gccgaggacg gtgtccggtt cgacgtgccg cagcgctact tgctggtgca gcatttggag
    21481 acgccggatc tcgtcagcgc cgttaccgga attgacgtcg agaccgtggt ccgggatctc
    21541 taccgggcca ccggtgacgg cttgctgacc aggccagcgg acgccgatcc ccggctgccc
    21601 gagtactgct attcaaccgg cgagcgcctg gaacggacct tctacacgcg caatccgccg
    21661 acgacgaaag cggtccggca actggtggcc gaccatggtg gcaacgggat cgtggtttcc
    21721 ctgccggagt gcgtcaaccg atatgccttc gtccgggatc tgttgcgcgg cgccgacttc
    21781 caccggctgc cggaggaccc ccgccggctg cgcgagtggg ccatggtgat gtccgccgtc
    21841 ggctgcctca acgcgatcga ccgtgacttg atccccgccg gcgccgacgt ggtcatccat
    21901 ggctcgggcg cgtattccga aggtgagttc caccagatcg accggagtcg gctgatcgag
    21961 gtgaacaccc cggacgaggt acgcgcgctc atcagcggtg cgatccaggc ggacggcgag
    22021 cgtggttgat gagtacagcg gtggtcaagc ctgctgagga cgtggccggt cggctcgctc
    22081 ggatcctgac gaccggtcgg tccggtccat tcctgggcac cccgtgcggc gtgctcgccc
    22141 agctgtaccg cgagatcgac gccgcgtgcg ggatgcggac catcgcgcgg gaggactccg
    22201 cggtcggggt cgcggccggc gcggcactgg ccggccggca gccggtggtc ttgatgcaga
    22261 actccgggtt cggccagtcg gtcaacgcct tcgcgtcatt gatcatgccc tgccggctcg
    22321 acgtggtcac ggtcatcagc gtccggggca tggccccgga caacactgag gagaacagcg
    22381 ccatgggcac gctcactccg acgatcctgg ccggtctgaa cgcggacgtc cgctggctcg
    22441 ccgacggcgc cgacctgacc gaggccactg ccaactggct cgccaccgag gtggacgaac
    22501 cacggttcct gctcatcgcc cctggacttt tcggctggcg cccgtgacga tccgcacgat
    22561 gacgcactcg ccgcagaaca aggcggcagc catcgccgag atcatcggcg cgtcggggga
    22621 cacgccgatc gtgttcacca ccggctatgc ctgccgtatc gccaacgaca tccaggacaa
    22681 gcccgggcac ttctacatgc tcggctccat ggggctggcc ggctgtgtcg ccgtgggcgt
    22741 cgcggccggg ctgtcccgac cggtgatcgt cgtcgacggg gacggctcgt tggcgatgaa
    22801 tcccggcgtg ctgttgctgg ccgccgagtt caccgggttg ccgctgatcc acgtcgtgtt
    22861 ggatgaccgc gcgtacagtt ccacaggcgc ccagcccacc ccgccggtcg ggaacatcga
    22921 gtcctgggcg gcctcgctcg gctatctggt gttgtcccca ccactggccg gcggcgtcgg
    22981 ctccgtggtg gccggcctcc tcgccggcga gctcacccga ccgcatctgt tgcgcctccc
    23041 ggtcgcgccg gacgggcgca acgtccccgg ccggatcgag ggccgcctgt ccggatacgc
    23101 ggcccggttc cgcacgcact gccgaggctt gcgggccggc tccgaactgc ccgtcgtgtg
    23161 aacggtcggc ggccgtcgag aagtggaagg tcgatgcaac ctgttgagag cggacgcgga
    23221 cgagcagtcg gtacctgcgg cgagctcgtt caaggcacgg ttgacggccg cgagctgatg
    23281 gtgacctttc ctgtcgactg gtacagcgac gtggtcgtgc gtggctccta cttgcccggc
    23341 gtccgggtgt ggccacggtc gaaggtcaag gtccgccgga tgtgcgatgt gttgctcgac
    23401 cggctggtcg gagccagttc cgccgatgtc gggctggacg tgctggtcag ctcgatgatc
    23461 ccggagggcc gcggacacgc gagcagctcc gcggacctga cggcgctgtg ccgggcgatg
    23521 gcgcagtggc tcggcgtgcc gctcgccgac gacgacatca tgcggctgtg ctgcgagctg
    23581 gagccgtccg atgcggtgtg ccgtccggtc cccacgctgt tcgacttcat ccgcggcgag
    23641 gtgctgttgt gctacgacga cccgccgccg atggctgcgc tggtgctgga cgagggtggg
    23701 gcggtggaca ccgtgaccat gcggcggctg ccctgtaccg aggccgagag cgagcggttg
    23761 gccttggcgt tcgacttggt ggaccgggga ttccggctgg gtgatctcgc gttgatcggc
    23821 cgggccgcga tgatcagcgc cgaggtcaac cagcggcggg tgtacaagcg gaacttcgag
    23881 gttgccaggg acgtggcgga tgcctgtggc agttacggag tgtcggtcgc acacagcggg
    23941 accacgctgg cactgctgtt cgatcagcac gaggtggagg gcatccgcgc ggcccacgcg
    24001 gcgctgagaa cagtcgccgc cgactgcgaa ctgtttctgc tcaacgcggt ggtcccgacg
    24061 cggcgggcgg cacccgatct gaccgaactg cccacccgct gacggcgaac gagtggggtg
    24121 attccctttt ggccggttga ttcctcgggg gtgtcagtgg gtgccatcag attcgctctg
    24181 ccgaagcagg gccggccgat cagcatcgcc gggtaccgaa cggccgcccg ccgggtcctg
    24241 cccgacctgg tgtgggcgta cgtggagaac ggcgcggacg attccgtcac gttggcggcc
    24301 aaccggtctg cgttcgcccg ctggtccctg cgtcaacgag tgctgcgcag ttccgccggg
    24361 cggaaaacgg ctgcccggtt cggagacacc gagctggcga ttccggtgat gattgcgccg
    24421 accgggatca acggactggt gcactggcgc ggcgagttgg caaccgcatg cggtgcggcc
    24481 gcagccggta gcaggatcgt gttgagcacg gcagcgtctt attctgtcga agaggtcgcc
    24541 gcggcgagcc cggtcggaca ctggctccag gtctatccgt ggcgcgatcg agaactcatg
    24601 gactggctgc tcgagcgcgg ccgacgatcg gattgcccca cgctggtggt cacggttgac
    24661 acaccggtgt tcggaaaccg cgaaccggaa cggctgcagg gcatgagcat cccgcccgtg
    24721 ctcaccccca ggcacgtgtt ggacgccgcg ctgcaccccc gatgggcgta caaagtcctg
    24781 cgccaccagc gggtgttcac gggcaacctg gtcgggatga gcggagtgag ggccggcgcg
    24841 ctcgcagcga aagtgcgccg ggaacggatg atggccggcg aactcgactg ggacgacttc
    24901 gccagggtcc gcgcgcagtg gcagggactc tgttacgtca agggaatcct ggacgcagac
    24961 gacgcagaac gcgctgtctc gctcggtgcg gacgggatca tcgtgtccaa tcacggcggc
    25021 cgacagctgg acggcgcccc ggccacactg gacgcgctgc cggggatcgc cgaccggctg
    25081 gcccaccggg ccacggtgct catcgacggc gggatccgca gaggcaccga cgtggtgaag
    25141 gctctgtgcc tcggtgcgga cggctgcctg atcggtcggc cggcgctcta cggactcgcc
    25201 gtgggcggcg agtccggggt cgaacacgtg ctcagcatcc tgcgcgagga aatcgaccgc
    25261 accctggcgc tcatgggctg ctcggacatc gccgatctcg gccgggactg gctcatcccc
    25321 gggtagcacc gccggcgcca ccggggacgg ggttccgccg aacgggtgcc gtgcatgggt
    25381 cagtcgggct cgtcgccgtc ggtggccggg gtgccgtgct gcgtggacgg tcgccgatct
    25441 ctcgtggcca acagggcgat gacggtgatc agcagtgtga tcgtgatcgc cacggtggag
    25501 ccgaggagcc cgtcggtggc ggcgcggagg tggtcgccgg ggtgggcggt cagggagccg
    25561 aagtacagcg ctccgatgac ggctatcccg atcgtcgatc cgatgcgctg ccctgtttgc
    25621 aggacggcgc cggcggcact tccctcggtc aggggcaccg tttgcagagc cagcgtcagg
    25681 ttcggtccga tcaccagccc gctgcccgcg ccggcgagca gcagcggccc ggccacgagc
    25741 agccacacaa ggccgcccgc gcggtggccg atcagggcga tcagcccggc ggatcccagc
    25801 gcgacggcgg ccagtccgat gacgaccaac cggcgtccga cccggtggac cgcgcggccg
    25861 gccagggggg cgctgatcgc cgcgccgagc gcagtggggg tccctacggc gcctgcggcc
    25921 agtgccgagt aacccagccc cagttggaag tacagcgata ccatgaacgg gatgccgaca
    25981 aagccgacga agtagcccat gccgacgaac gcgctgatcg cgtagtcgcg ctggcgcagc
    26041 atcgcgaggt tgaccagccg tggtcggccg gagcgcgtgc agtgctgctg ccaggcgatg
    26101 aaacacgcca gcagcagggc cgacagcccg agcaggtgcc agggcaccga cggctgtcgc
    26161 tgctcggccg cgatcagcgg caggatcaat gtggcgacac cggatccgag cagtgctatc
    26221 ccgagcaggt cgagtcgcac tcctcgtatc tgctgccgat cgcgggggag ccaccgcagg
    26281 cccaacggga gtgacagcgc cgcgatgggc acgttcacca agaacaccca tcgccatccg
    26341 tcggcagggc cgccggcctg gatcagcaga ccgccgacca gcgggccgat ggccgtagtc
    26401 gcggcgatca tcccgctgta cgccccgcct gccttgccca gttccgggcc ccgtgcgaac
    26461 agctgccgca tcagcccgac cacctgcggc gtcaccaccc ctgcggcaag gccctgcacc
    26521 agcctggcgg ccacgagcca ccacccggag gccgccagcc cacaggccag gctgccgaac
    26581 gcgaagaagg ccagccccac cagcagcgtg cgccgtctgc cgagctgatc gcccagggcc
    26641 ccggcgggca ccagcaccac cccgaaggtc agtgtgtagc cgaacgccgc ccacaacacc
    26701 tgcccggccg acaagtgcag cccggcctgc atggagggga ccgcgacgtt gatgacgctc
    26761 acgtccagca gcgtcacgaa tcccgccagc aggcacaccg aatacgctgc ccagcgccct
    26821 gcctgcactg gttcggccac gtcggtctct gtcataccgg cccttccgcc ttggctgatc
    26881 acgtctactc gctgacttca cttcagccgg tctcaccgga gccgatcaat gaccaacatg
    26941 gtcatggaac aatcaccgga aggaatcgat cgaggcgcgg agggcggtag tggtggaggt
    27001 tcggcagttg cgctacttcg tcgccgtcgc cgagtgtgaa cacttcggcc gggcggccga
    27061 gaccctgcac atcgttcaag ccgcggtgag caagcaggtc gcgcggctgg aacgcgaact
    27121 cggactcacg ttgttcgacc ggtcccaccg ccgggtccgg ctcaccccgg acggccaggc
    27181 cttcctggcc cacgcacgcc gcgcgctacg cggcctcgac cgcgccgccg ccgcggcggc
    27241 cgacctggcc gccggtaaca caggcttgct gcgcatcggt agcagcattg gactcggccc
    27301 ccgcgtcgac gccgcactcg cggccgtccg cagcgcgtac cccggcatca cgctccaggt
    27361 gacgacctct gcctcgacaa ccggtcatct cgccgccgtc gccgactacg atctcgacgc
    27421 cgccttcgtg gccgcaccac aggccacccc gggcgtgcag gttcaccacc tctgggacga
    27481 accgttgctc ctggccgtcc ccgctgcacg cgccggctcc gcaggagacc tcgccaccct
    27541 cgctgaactc cctctggccc gatacgctcg cgcggacagc cccggtaccg acgacctgat
    27601 caccgccgcc tgccgggcgg ccgggttcac cccccggaag ggccccactc tcacccgagc
    27661 ccaagacctc ctcaccggac ccgtttccgc cggagactgc tgggccgtac tcgccgcaga
    27721 cctcctccac cacgtccccg ccgctgtcgc cctcgtcccg cccgttccac cggtcctcgt
    27781 gcccaccgca ctcgcgctac ccgatcccgt acgccgtgcg gtcgtgctca acctgctcac
    27841 cgtcgcacag gccgggaccg tctgacgacc ggtgttcccg gcccgacacg ccgggtccat
    27901 cccgtgaacg gtgttttcgg tgttggccgc aggcaccacg aatgaacgcc atatctgatc
    27961 ttacccatgt gatcttggcg cagaaaatcg cacgtcggcc tggagtgccg aagctttccg
    28021 gggcggggca accggtccct gttcggccca cgaccactca ataaccgtcc accgactcat
    28081 tcgccttgac aaatatggcg gccgggctgg aagctcacat gatgaatcgg tggttggtta
    28141 ctggtgcggg aggaatgctc gggagggatt tggtgcgggt tttggaggcg ctgaacgaac
    28201 cagtgctggc tgccactcgg caggatctcg acatcaccga ccgattctcg gtccgagccg
    28261 ttgtctccag gtatcgaccg acggcgatcg tcaattgcgc agcatggacg agatttcatg
    28321 aagcggagac cagtgaagcg gaggcccatc ttatcaatgg aagaggggca agagagctgg
    28381 ctacgatatg cggcgatcga tcgattcggt tggtccatct ctccaccgat tacgttttcg
    28441 acggcgcgag ccgccggccc tatgccgaaa gcgcggccac cggtccgatc aacgcctacg
    28501 gccggacaaa gctggccggc gagcaagctg tgctcgagtt gctgccggac gacgggacga
    28561 tcgtgagaac cgcttggctg tacggtcgac acggcacgaa cttccttcgc aagatggtcc
    28621 ggttggagca gacgcacaag acggtggacg tggtagacga tcagtggggc cagccgacgt
    28681 ggagcgtgga tttggcacaa cagatcgtgg cactcgttcg gcacggtgcg tccggcgtgt
    28741 tccacgggac aagctcaggc gagaccacgt ggtacgactt cgcccggatg atcttccggt
    28801 tgctcggtgc ggatcccgga cgaatccgcc cggtgcgcag cgaccagatc gccggcggcg
    28861 aactgcgtcc ccggtacacg gtgttggggc atgccgcctg gcgcgaggtc gggctgacgc
    28921 cgattcggca ctggtccgcc gctctggagc ggtcgtttcc ccttctggct gacgaggaat
    28981 ggtaatcctc ctcgagtaaa agaaaggagg ttccgcggat gcgacttctg gtgacgggcg
    29041 gtgccggctt cattggctcg gagttcgtcc gggctacctt acgtggcgtt ctgccgggct
    29101 catcaggaac ccaaatcacc gttctcgaca aattgacata ttccggcaac gagctcaacc
    29161 tggcaccgat cgcggacctg gagacttacc ggttcgtgca aggcgacatc tgtgatcggg
    29221 gtctggtgga cgacgtggtc gccggacacg acgcgatcgt gcacttcgct gccgagacgc
    29281 atgtggatcg ctcgatcgaa ggtgccgcct cgtttgtccg tacgaacgca ctgggtacgc
    29341 aggtgttgct ggaagcggcc tcccgtcacc gactggggcg gttcgttcac atctcgaccg
    29401 acgaggtgta cggatcgatt tccgagggcg cctggaccga ggcgtccccg gtggccccga
    29461 acgcaccgta cgcggcagcc aaggcggcgg gagacctgct ggcgctggcc tggcaccgga
    29521 cccggaagct cgacgtcgtg gtcaccagat gcaccaacaa ctatgggccg taccagtatc
    29581 cggaaaagct gatcccgctg ttcacgacca atctcctgga cgggcagcag gttccggtgt
    29641 acggggacgg ccacaaccgc cgacagtggc tgcacgtgtc ggaccactgt cgcgccatcc
    29701 agtgcgtgct cctcggtggt cggcccgggg aggtttacca cattggcggt ggcaccgagt
    29761 tgaccaacct cgaactgacc gaacacatcc tcgaggcctg tggtgccggt tgggaccggg
    29821 tgcggcatgt tccggacagg ttgggacatg atctccgcta ttcgctggac accaccaaaa
    29881 ttcgtacgga actcggttat tcgcctcgtg tggcgttcgc ggacgggctg gcggagacag
    29941 tggagtggta ccgcactcac cgtggttggt gggaaccgct taaaaatcct gacaaagcga
    30001 cgggttcacc gaccgacgcc ggcagatgac ggcgcaacca ggcggaggga cgcctcgtgg
    30061 acgtcgtcac tgatctctca gcggttccgc cctcgaccag ttggacgcca cggcaccggt
    30121 gagctcggcg agcagttgcc gtgcaggcgt tgccggacac cggtgtcgct ccaggcccgc
    30181 ggccgccgcc ggcggaacag tggttcgatc cgcatccaga actcgtcgga cattcccgtg
    30241 agggggagga agagatgcag gacatcgtgc gtcccatcaa cgagtgccgg gtgtgcgggc
    30301 acaacgattg gcttgatgtg gtctcgttcg gatcgacacc attggccgga aacctgctcg
    30361 gcacggaaga tgacccgagg gacgagactc tgttcccgct ggatgtcggc gtgtgccgga
    30421 aatgctggct gatgacactg cgccatgtca tcgaaccgaa cgcccttttc gggcactacc
    30481 gttacgtcgc ctcggacgca ggatcgatca tccagcacat gcggcagctc gtcgaactgt
    30541 gtatccggtg ggtcggcctg accgacagag atctcgtcgt ggagttcggc agtaacacag
    30601 gtgctcacct ggagctgttc cagcaggccg gcatgcgggt ggtcggcgtt gatcccgcgc
    30661 gcaatctcgc cgacatcgcc aatgaccgtg gcgtcacaac gatccctgcc ggcttcacca
    30721 ccgaagtcgg ccaggagatc acgactggac atggtccggc gcgactggtg ttcggtcgcc
    30781 aatgtttcgc ccacatccac gacgtccacg aagtccttga cggagtctcc gccctgctgg
    30841 cgcctgatgg cctgttcttc gtggaagttc cctatctggt ggaactgctc gcaaacaatc
    30901 agttcgacac catctttcac gaacatcttt cctacttttc gctcggcgcg ctgtgcaggc
    30961 tgttcgaggc gcacgggctt cgcgtcgtgg acgtacatac agtcgacgtg cacggcggct
    31021 cgatcgtggt cttcgccgcc ccggccaccg ccggctatga ggtgcggccc gctgttgccg
    31081 agatgctcgc ggaagaacgc agccagggca tcgcagagga gagtacatac cagaaattcg
    31141 ccgagcgtac ggaacgggtg cgcgcacaga tccgggaact ggtgcgcagc ttggtggcag
    31201 acggcaagac agtggctgga tacggcgcac cgaccaaagg cagcgcactg ctgaccgcat
    31261 gcgggctggg acatcaggag atccggttct gcagcgacac aacagccctg aagcagggaa
    31321 aactcctacc gggctccaga gttccgatct ggtcgccgga acaagcaagc gaccacgtac
    31381 cggactacta cctgctgttg gcctggaact acgcgtcgga gatcatcacc aaggagaagt
    31441 cgttcctgga agggggcggc cgtttcattg ttcccatacc cgaaccgcgc gtgatatcgg
    31501 cggagtcggc gtggtgacgt cgaaggctgc accaacgatg atcaggcgtt gtcaggttgc
    31561 tgatggggtg gctggttgag gggaatcctt cttgcgggcg gtaccggctc caggctgtgg
    31621 ccggtcaccc gggctgtttc caagcagttg ataccggtct tcgacaagcc gatgatctac
    31681 tacccgctga ccacgctgat gatggccggc atacgggaga tactggtgat cacgcgcccc
    31741 gaggaccagc gccagttccg tcaccttctc ggcgacggct cgcaactggg cctgtgtctt
    31801 gagtacgccg tccaagagaa gcccgagggt atcgcgcagg cgtttgtcct gggtgccgac
    31861 ttcatcggcg accagtcggt ggccttggtc ctcggggaca acatcttcca tggcgcgggc
    31921 ctgggaacca ggctgcgtca gtacagcgat cccgccgggg gacggatctt cgcctacgtc
    31981 gtagccgacc ccagggccta cgcggtagtg gagttcgacg aggccggtac ggcagtctcc
    32041 atagaggaga agccggccag tcccaagtcg cgctacgccg tgccggggtt gtacttctac
    32101 gacaaccggg tgctggaggt cgcccgcgac ctgatgccga gtcagcgtgg cgaactggag
    32161 atcaccgccg tcaacgaaac ctatctgaaa tggggccagt tgcgggttac cacgctcgac
    32221 cggggcgccg cctggctgga cacgggaacg ttcacctcct tggtccaggc gtcggagtac
    32281 gtgcgtgtgg tggaagaacg gcagggcctc aagatcggct gcgtggaaga ggtcgcctgg
    32341 cgctgcggcc tcatcgggaa cgaccagttg cgggaactca gccgcccact gctcaagagc
    32401 ggctatggcc ggtatctcct cgacctgctc gccgatcagg agttgaagga gttgaagtcg
    32461 tcgtgaaact tcgcccgctc ggcatcgagg gcgcctggga gatcaccccc aagcagcacg
    32521 ccgatccgcg cggggtcttc ctggactggt accgcgtcga ccagttcgcc gcagaggtcg
    32581 gccgcccact gcggctggcc caggccaacc tgtcggtatc cgttcgcggc gtggtgcgcg
    32641 gcgtccactt cgccgatgtg ccgcccgggc aggccaagta cgtgacgtgt gtgcgcggcg
    32701 cgctgttcga tgtggtggtg gacctgcggg tcggctcgcc gacttacggg cgctgggaag
    32761 gcacccgact cgacgatgtc agccgtcgtg ccgtctacct ctcggaaggc atcgggcacg
    32821 gcttctgcgc gatctcggac gaggccacgc tgtgctatct gtcttcgcag acctacaacc
    32881 cggcgtccga gcacggtgtg cacccgctcg atccggaact ggccatcaat tggcccgtcg
    32941 agactccgct gctctccgcg cgtgaccagg acgcgctcct gctcgccgaa gcccgggact
    33001 ggggcctgct gcccagctat gcggcctgtc aggcgctcac ggcgttgacc agtcaatgac
    33061 ggtcttggcg tgccgaccga agggccggca cgccacggcg gcgggtgacg gggacgacgg
    33121 cgtccgacac gggcgtccag aaggcggcac gcgtcctcgg cctccctgac gcacggcccg
    33181 agcgccgagc cggcgatccg ggtgccatcc cgcccctcga caaccggagt tcggtgcgag
    33241 gccgggaccg gcggcctgac acagcgcgac tggcgaccgc ggagggttac gccggaaata
    33301 gtgccccggg cgctacgtga caaggcatca agaaaccccc tgagtgcccc tctgtcgcat
    33361 tttcagtggg tcaaggcaga ggggatcggc ctaggtggcg cgggagtcgc acggtggcgt
    33421 acaggggtgc tctcgtcccg tcggccaggg atggctccgg tacgctcggc agcgtctcgg
    33481 tcggcgacat ccagtggttc gtgtgccttg gggtcctgtc cgggctgtcg tgccgtgtct
    33541 ccccagctgt ccggccgctc ctgcatcgtg gtgcgggagc cgggtccgct atgcccgaaa
    33601 gagagcgtct gtgactactt acgacactcg caccgccacc gacacccgcg gatccgagca
    33661 gcccggccac gtggggacgg cgtcgtatga cgccaacgcg atcaccgttc tggacggcct
    33721 ggacgccgta cgcaaacggc ccgggatgta catcggctct accggggagc gggggctcca
    33781 tcacctggtg caggagctcg tggacaactc cgtggacgag gcactcgcgg gggtggccga
    33841 ccggatcgac gtgacggtcc tggccgacgg cggggtgcgg gtggtcgaca acggccgcgg
    33901 catcccggtg gggatgcacc cggtggagaa gcggccggcc gtcgaggtgg tgctgaccgt
    33961 gctgcacgcg ggcgggaagt tcgggggcgg cgggtacgcg gtctccggcg gtctgcacgg
    34021 tgtgggtctg tcggtggtca acgccctgtc gacccggctg tcggcggaga tctggaccga
    34081 cggccaccgg tggacgcagg actacaggga cggcgctccc accgccccac tggcccgcca
    34141 cgaggccacc tcccggacgg gcacctcgct gacgttctgg gcggacggcg acatcttcga
    34201 gaccaccgaa tactccttcg agacgctggc caggcgtcat caggaaatgg ccttcctcaa
    34261 tggtgggctc accctgaccc tcaccgacga acggtcctcc gcgcgcgcga cggccgcggt
    34321 cgacgaagcc gactcggacc cgacggcgaa gacggtctcc taccgctacg acggcggcat
    34381 caccgacttc gtcgtccacc tcaatgcccg caagggcgag ccggcccatc cctcggtcat
    34441 caccatcgcc gccgaggaca cggaacggct gttgtcggcc gagatcgccc tgcagtggaa
    34501 cggccagtac accgacagcg tgtactccta cgccaacgcg atccacaccc atgagggcgg
    34561 cacccacgag gagggcttcc gcacggcact gaccaccgtg gtcaaccgct acgcgcggga
    34621 gaagaggctg ctgcgggaca aggacgcgaa cctctccggc gaggacatcc gcgagggttt
    34681 gaccgcgatc atctcggtca agctcggcga accgcagttc gagggccaga ccaagaccaa
    34741 actcggcaac accgaggtgc gcaccttcgt tcagaagatc gtccacgagc acctggccga
    34801 ctggttcgac cgcaacccga acgaggccgt ggacatcgtg cgcaaggccg tccaggccgc
    34861 cacggcccgg gtcgcggccc gcaaggcgcg cgacctgacc cgccgcaagg gcctgctgga
    34921 aacggcggcg ctgccgggca agctgtccga ctgccagtcg aacgacccgg cgacgtcaga
    34981 gatcttcatc gtcgaaggag actccgccgg cggctctgcc aaagccggcc gcaatccgca
    35041 gtaccaggcg atcctcccga tccgcggcaa aatcctgaac gtcgagaagg cgcggatcga
    35101 caaagtactg cagaaccagg agatccaggc gctcatctcc gcgttcggca cgggtgtgca
    35161 cgaggacttc gacatcgcca agctccgtta ccacaaaatc attctgatgg cggacgcgga
    35221 cgtcgacggc cagcacatca gcaccctgct gctgaccttc ctcttccgct tcatgcggcc
    35281 actggtcgag gaggggcacg tccacctctc ccgaccgccg ctgtacaaga tcaagtggag
    35341 tcgggaacac gtcgaatacg cctactccga ccgcgaacgc aacacactcc tggaacgggg
    35401 ccgccgggac ggccgccgga tcagggacga ctccatccag cgcttcaagg gtctgggcga
    35461 gatgaacgcc gaggaactgc gcgtcaccac catggacccc gaccaccggg tcctgggaca
    35521 ggtcaccctc gacgacgcgg ctttcgccga cgacctcttc tccgtcctga tgggcgagga
    35581 cgtggaagcc cgccgccact tcatccagcg caacgcccag gacgtccgct tcctcgacat
    35641 ctgaccccgg acaccgctcc cgcccctctc gacgcgtgac ccaaagcccc accgctacct
    35701 ctgttactca ggagagcact gcgtgagtac attccccgcc ccggccgccg gcagccgccc
    35761 ccaggacggc tccgactaca ccgcacggca cctgatggtg ctcgacgggc tcgaagccgt
    35821 gcgcaagcgc ccgggcatgt acatcggatc cagcgacagc cgcggtctga tgcactgcct
    35881 gtgggagatc atcgacaact ccgtggacga ggccctggcc ggtgcctgcg accacatcga
    35941 ggtcatcctc cacgacgacg gttccgtgga agtcaccgac aacggccgcg gcatccccgt
    36001 ggacacggaa ccccgcaccg gcctgtccgg agtcgagctc gcctacacca aactccacgc
    36061 cggcggcaag ttcggcggcg gctcgtacgc cgcctccggc ggcctgcacg gcgtcggcgc
    36121 ctccgtggtc aacgcgctgt ccgcccggct ggacatcgag gtcgaccgcc acggccgcac
    36181 acacgccatc agcttccgcc gcggcgcacc cggcacctac tccgcccctg gacccgacgc
    36241 ccccttcacc cgcgcccagg gactgcaccg gaccgccaga atccccaagt cacggaccgg
    36301 cacgcgcgtg cggtactggg ccgaccgtca gatcttcctc aaggacgcca agctctccct
    36361 ggagaacctc catcagcgcg cccgccagac ggcgttcctg gtgccgggcc tgaccatcgt
    36421 cgtgcgcgat gagtacgggc tcggtgaggg cggcagcaag ggcgaggagt ccttccgttt
    36481 cgacggcggc atcagcgagt tctgcgagta cctggccgcc gacaagccgg tctgcgacgt
    36541 cctgcgcctc accggccagg gcacgttcaa ggagacggtc ccggtcctgg acgagcacgg
    36601 gcagatgacc ccgaccgagg tcacccgcga gctcggcgtg gatgtggcgc tgcgctgggg
    36661 gaccggttac gacacgacgc tgcggtcgtt cgtcaacatc atcgccacgc ccaagggcgg
    36721 cacccatgtc gccgggttcg agcaggccgt ggccaagacg atgaacgagg tgctgcgggc
    36781 caagaagctg ctgcgcgtcg cggaggacga catcgtcaag gacgacgcgc tggagggtct
    36841 gacggccgtc gtcaccgtgc gcctggccga accccagttc gagggtcaga ccaaggaggt
    36901 cctgggcacc tcggcggccc ggcgcatcgt gaacaccgtg atctccaggg agctgaaggc
    36961 gttcctgacc tccaccaagc gtgacgcggc cgctcaggcg cgggtcgtga tggagaaggc
    37021 ggtcgccgcc gcgcgcacgc gtatcgcggc gcggcagcac aaggacgcac agcgtcgcaa
    37081 gacggcgctg gagtcctcgt ccctgcccgc caagctggcc gactgccgca gcgacgacgt
    37141 cgagcgcagc gaactgttca tcgtcgaggg cgactcggcg ctcggtacgg cgaagctggc
    37201 ccgcaactcc gagttccagg cgctgctgcc gatccggggc aagatcctca acgtccagaa
    37261 gtcgtccgtg accgacatgc tgaagaacgc cgagtgcggg gcgatcatcc aggtcatagg
    37321 ggcgggctcc gggcggacct tcgacatcga cgcggcccgt tacggcaaga tcatcatgat
    37381 gaccgacgcc gatgtggacg gttcccacat ccggacgctg ttgctgacgc tgttccatcg
    37441 ctacatgcgg cccatggtcg agtcgggccg ggtgttcgcc gcggtgccgc cgctgcaccg
    37501 catcgagctg gtccagccca agaagggcca ggacaggtac gtgtacacgt actcggaccg
    37561 ggagctgcgc gacaggctca tggagttcca gagcaagggc gtgaggtaca aggactccat
    37621 ccagcgctac aagggtctgg gcgagatgga cgccgatcag ctggccgaga cgacgatgga
    37681 cccgcgtcat cgcaccctgc gacgcatcaa cctctccgac ctggaggccg ccgagcaggt
    37741 cttcgacctg ctcatgggca acgatgtggc gccgcgcaag gagttcatct ccagctccgc
    37801 ggccacgctg gaccggtcca ggatcgatat ctga
//
