LOCUS       BGC0000834             23218 bp    DNA     linear   BCT 24-JUL-2013
DEFINITION  Streptomyces niveus strain NCIMB 9219 novobiocin biosynthetic gene
            cluster, complete sequence; and GyrB_R (gyrB_R) gene, complete cds.
ACCESSION   BGC0000834
VERSION     BGC0000834
KEYWORDS    .
SOURCE      Streptomyces niveus
  ORGANISM  Streptomyces niveus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     On Apr 24, 2012 this sequence version replaced AF170880.3.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:46:00
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..654
                     /codon_start=1
                     /gene="novE"
                     /gene_functions="biosynthetic (rule-based-clusters) other:
                     LmbU"
                     /gene_kind="biosynthetic"
                     /note="similar to LmbU protein from Streptomyces
                     lincolnensis"
                     /product="regulatory protein NovE"
                     /protein_id="AAF67498.1"
                     /sec_met_domain="LmbU (E-value: 2e-84, bitscore: 272.6,
                     seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVASGRTASKGRGNGATPVRPTAGDATPVDSGQPSDTTYGGLEVS
                     AERTRLRIPRDLSLEAWCRLGGRILAVCDSSVWWIGDWLVFGQNQYGDRYRRAMKETKL
                     DYQTLRNYAWVARKFEPSRRRDSLTFQHHMEVAALSEAEQDHWLDFAVRLNWSRNELRK
                     QIRASLSGEEDDLRCEVQLNLQLDELRLERWREAARGSNLTLTDWILSVVDGAV"
     protocluster    1..23218
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3075:20191]"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3076..20191
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="1"
     protocluster    1..23218
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[0:15206]"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or fom1 or bcpB or
                     frbD or mitE or vlmB or prnB or CaiA or bacilysin or
                     orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..15206
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or fom1 or bcpB or
                     frbD or mitE or vlmB or prnB or CaiA or bacilysin or
                     orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="2"
     cand_cluster    1..23218
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /detection_rules="(LmbU or Neocarzinostat or fom1 or bcpB
                     or frbD or mitE or vlmB or prnB or CaiA or bacilysin or
                     orf2_PTase)"
                     /kind="interleaved"
                     /product="aminocoumarin"
                     /product="other"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..23218
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000834"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23218
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="aminocoumarin"
                     /product="other"
                     /region_number="1"
                     /rules="(novK or novJ or novI or novH or SpcDK_cou)"
                     /rules="(LmbU or Neocarzinostat or fom1 or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..654
                     /gene="novE"
     misc_feature    565..567
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            730..1818
                     /gene="novF"
     CDS             730..1818
                     /codon_start=1
                     /gene="novF"
                     /note="prephenate dehydrogenase"
                     /product="prephenate dehydrogenase"
                     /protein_id="AAF67499.1"
                     /transl_table=11
                     /translation="MRTAVIIGTGMIGTSIGLALRKQGVDSYLMDTSPVALRIAEAVGA
                     GTAEEPPETVDLAVVAVPPVHVAPVIASHQSRGTARFYVDVAGVKVSTRRELDALGCDL
                     ATVVGGHPLVGRPGSGPLAARGDLFDGRPWALVPAVGTDAAALNRALELVAACGAIPVV
                     LDAEAHDRAIALGTLVPQIALTLVAARLTEADSGALRLLGSVWSEIPQLVGVDSATSWT
                     QVLAANAAPVVGELEKLSRDLASLLETLRGVADGDGSLAEPDGRLLEFIQRGIDGSNRV
                     PGRYGIPTETALADVDVSVDDRPAELARLFDDVAGAGVVMRGIDISQRPDSPDRTVTIS
                     VTPRDAENLLHELRRRKWPANS"
     misc_feature    1324..1326
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1924..2880
                     /gene="novG"
     CDS             1924..2880
                     /codon_start=1
                     /gene="novG"
                     /note="regulatory protein"
                     /product="regulatory protein CloG"
                     /protein_id="AAF67500.1"
                     /transl_table=11
                     /translation="MTNSGDEEITPASLKATRKGERVSIGSLLPPSELVRSGESTEHIR
                     VLAETDEDLPPIVVHRGTRRVVDGMHRLWAARFRGDESIEVVFVDGSPADVFVLAVELN
                     RAHGLPLTLDERKSAAAQIMDSHPHWSDRKIARTTGLAASTVASLRSSSTAGTVGRRTG
                     QDGRSRPNDGTDGRQRAAALLARNPNASLREVTRAAGISVGTASDVRARLRRGEPALTA
                     RQQAVMKLRPAAAQRSGPDYGRVLENLRKDPSLRFTDLGRRLLRLLDGSVPGSVEQIAQ
                     IADGVPEHCRTVVVDMARECAAAWQHLADQLADRDTA"
     misc_feature    2008..2010
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3076..4878
                     /gene="novH"
     CDS             3076..4878
                     /NRPS_PKS="Domain: AMP-binding (26-424). E-value: 2.6e-98.
                     Score: 321.1. Matches aSDomain:
                     nrpspksdomains_novH_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (531-597). E-value: 5.4e-19. Score:
                     60.0. Matches aSDomain: nrpspksdomains_novH_PCP.1"
                     /codon_start=1
                     /gene="novH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     377.4; E-value: 1.5e-114)"
                     /gene_kind="biosynthetic"
                     /note="non-ribosomal peptide synthetase (L-tyr)"
                     /product="peptide synthetase-like protein"
                     /protein_id="AAF67501.2"
                     /sec_met_domain="novH (E-value: 0.0, bitscore: 1109.6,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFNTRANKASDQSPTIPTESATLAELWERTVRSRPSSPAIVTNGE
                     TLSYDEVNARANRLARLLLDEGAGPGRLVALALPRSSHLVISVLAVAKAGAVFLPLDVN
                     HPRERLSYQLADARPALLCTVRSAAARLPDGIEMPRVLLDSPERTAVLDALPDTDLTDD
                     ERGGPLAATDLAYVIYTSGSTGRPKGVALTGAGLPALAAAKVAAMRVTGDSRVLQFASP
                     GFDAYLTELLAAFTAGATLVVPGTDTLAGDPLRRALRDGRVSHAVLPPAAVATMSPDAV
                     PDLRVLVVAGEACPAGLVERWAPGRLLINAYGPTECTVCATMTGPLTPTDEVTIGRPIP
                     GVSVYILDAERRPAAPGEIGELYLSGAGLAQGYLNSPDLTAQMFVPNPFAADGERMYRT
                     GDLASRRADGDILFHGRIDDQVELRGFRVELGEVESVLSQHPDVAQAVAALWTDPAEGP
                     QLVTYVVPAPGTTPSAGELREHAGRFLPDFMVPSAFTTIDAVPLTPGGKTDRAGLPDPV
                     KATQPAGLGPRTPAEKVLCDIFRDLFDLVEIDVRSNFFEMGGNSILAVDLIQRAQEAGL
                     TLMPRTVIDHPTIEQLAAIATLEE"
     aSDomain        3154..4347
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_novH_AMP-binding.1"
                     /evalue="2.60E-98"
                     /label="novH_AMP-binding.1"
                     /locus_tag="novH"
                     /protein_end="424"
                     /protein_start="26"
                     /score="321.1"
                     /specificity="consensus: tyr"
                     /tool="antismash"
                     /translation="WERTVRSRPSSPAIVTNGETLSYDEVNARANRLARLLLDEGAGPG
                     RLVALALPRSSHLVISVLAVAKAGAVFLPLDVNHPRERLSYQLADARPALLCTVRSAAA
                     RLPDGIEMPRVLLDSPERTAVLDALPDTDLTDDERGGPLAATDLAYVIYTSGSTGRPKG
                     VALTGAGLPALAAAKVAAMRVTGDSRVLQFASPGFDAYLTELLAAFTAGATLVVPGTDT
                     LAGDPLRRALRDGRVSHAVLPPAAVATMSPDAVPDLRVLVVAGEACPAGLVERWAPGRL
                     LINAYGPTECTVCATMTGPLTPTDEVTIGRPIPGVSVYILDAERRPAAPGEIGELYLSG
                     AGLAQGYLNSPDLTAQMFVPNPFAADGERMYRTGDLASRRADGDILFHGRIDDQVELR"
     aSModule        3154..4866
                     /complete
                     /domains="nrpspksdomains_novH_AMP-binding.1"
                     /domains="nrpspksdomains_novH_PCP.1"
                     /locus_tags="novH"
                     /monomer_pairings="tyr -> tyr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       3340..3381
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novH_0001"
                     /evalue="1.80E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="novH"
                     /protein_end="102"
                     /protein_start="88"
                     /score="14.9"
                     /tool="antismash"
                     /translation="LAVAKAGAVFLPLD"
     CDS_motif       3598..3654
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novH_0002"
                     /evalue="9.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="novH"
                     /protein_end="193"
                     /protein_start="174"
                     /score="30.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVALT"
     CDS_motif       3769..3801
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novH_0003"
                     /evalue="2.60E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="novH"
                     /protein_end="242"
                     /protein_start="231"
                     /score="-0.6"
                     /tool="antismash"
                     /translation="LAAFTAGATLV"
     CDS_motif       4009..4035
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novH_0004"
                     /evalue="1.10E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="novH"
                     /protein_end="320"
                     /protein_start="311"
                     /score="11.5"
                     /tool="antismash"
                     /translation="YGPTECTVC"
     CDS_motif       4141..4227
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novH_0005"
                     /evalue="3.80E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="novH"
                     /protein_end="384"
                     /protein_start="355"
                     /score="44.8"
                     /tool="antismash"
                     /translation="PGEIGELYLSGAGLAQGYLNSPDLTAQMF"
     CDS_motif       4312..4377
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novH_0006"
                     /evalue="1.30E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="novH"
                     /protein_end="434"
                     /protein_start="412"
                     /score="33.3"
                     /tool="antismash"
                     /translation="FHGRIDDQVELRGFRVELGEVE"
     aSDomain        4669..4866
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_novH_PCP.1"
                     /evalue="5.40E-19"
                     /label="novH_PCP.1"
                     /locus_tag="novH"
                     /protein_end="597"
                     /protein_start="531"
                     /score="60.0"
                     /tool="antismash"
                     /translation="EKVLCDIFRDLFDLVEIDVRSNFFEMGGNSILAVDLIQRAQEAGL
                     TLMPRTVIDHPTIEQLAAIAT"
     gene            4882..6105
                     /gene="novI"
     CDS             4882..6105
                     /codon_start=1
                     /gene="novI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 313.8; E-value: 2.7e-95)"
                     /gene_kind="biosynthetic"
                     /note="cytochrome P-450"
                     /product="cytochrome P450"
                     /protein_id="AAF67502.1"
                     /sec_met_domain="p450 (E-value: 1.4e-16, bitscore: 50.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="novI (E-value: 5.3e-257, bitscore: 842.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRPTVSPSELEQIDLASPVLHAEYELDEIFRHLRADEPVYWQQ
                     PRNEQPGFWVISRHADVNEVYKDKEHFTTEHGNALATLLTGGDSASGAMLAVTDGVRHH
                     QVRNVLSRGFSARMLDLIAHTLQETVDGLLLAALERGECDAAQDIAADVPLGAICDLLE
                     IPHADRKYLLGLTSHAWSTDYADEPPEESWVAKNEILLYFSKLLKERRGGVREDMVSLL
                     ANCRIDGDPLKAAEQMANCYGLMIGGDETGRHAITGTILALIQNPDQWRALKNGDVDLN
                     TATEEALRWTVPSLHGGRKATGDVVINGRRINAGDVVSVWISSANRDETVFDAPDEFNL
                     ARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYSSILHGMS
                     SLPIRITG"
     gene            6125..6913
                     /gene="novJ"
     CDS             6125..6913
                     /NRPS_PKS="Domain: PKS_KR (17-190). E-value: 6.5e-23.
                     Score: 73.4. Matches aSDomain:
                     nrpspksdomains_novJ_PKS_KR.1"
                     /codon_start=1
                     /gene="novJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     251.2; E-value: 1.7e-76)"
                     /gene_kind="biosynthetic"
                     /note="b-ketotyrosyl-reductase"
                     /product="b-ketotyrosyl-reductase"
                     /protein_id="AAF67503.1"
                     /sec_met_domain="adh_short (E-value: 5.4e-39, bitscore:
                     124.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="novJ (E-value: 4.4e-152, bitscore: 494.9,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPADATTEVAVSQESVAMVTGAGRGIGAATAERLAAEGMAVIV
                     VDRTEQDTRATVAAIRTAGGRARGIGCDVAVAQAVTAAVATAVEEFGRIDVLVNCAGIN
                     RDRLLLTMGDQEWDTVLDVNLGGTMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTN
                     YATAKGAIAGFTRTLAAELGPHGVTVNAIAPGFVATPMVDELAERLGGDRDSVMSEAAK
                     SSAVGRIGTPEEIAATVVFVARPESGYLTGETVHVDGGRP"
     aSDomain        6176..6694
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_novJ_PKS_KR.1"
                     /evalue="6.50E-23"
                     /label="novJ_PKS_KR.1"
                     /locus_tag="novJ"
                     /protein_end="190"
                     /protein_start="17"
                     /score="73.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAMVTGAGRGIGAATAERLAAEGMAVIVVDRTEQDTRATVAAIRT
                     AGGRARGIGCDVAVAQAVTAAVATAVEEFGRIDVLVNCAGINRDRLLLTMGDQEWDTVL
                     DVNLGGTMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTNYATAKGAIAGFTRTLAA
                     ELGPHGVTVN"
     CDS_motif       6185..6259
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novJ_0001"
                     /evalue="6.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="novJ"
                     /protein_end="45"
                     /protein_start="20"
                     /score="12.5"
                     /tool="antismash"
                     /translation="VTGAGRGIGAATAERLAAEGMAVIV"
     CDS_motif       6566..6625
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novJ_0002"
                     /evalue="1.20E-06"
                     /label="PKSI-KR_m4"
                     /locus_tag="novJ"
                     /protein_end="167"
                     /protein_start="147"
                     /score="21.0"
                     /tool="antismash"
                     /translation="INFSSVAARGNAGQTNYATA"
     gene            6910..7644
                     /gene="novK"
     CDS             6910..7644
                     /codon_start=1
                     /gene="novK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     81.1; E-value: 1.5e-24)"
                     /gene_kind="biosynthetic"
                     /note="b-ketotyrosyl-reductase"
                     /product="b-ketotyrosyl-reductase"
                     /protein_id="AAF67504.1"
                     /sec_met_domain="novK (E-value: 7.9e-130, bitscore: 422.0,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRVAVVAGGGEHTGPAVALRLAAGGFDVALLGSEFTSADKTVRR
                     VEEYGRQCVTVRAELSDARSVAVAFGRVRTALSGPAVLVTCVGPQPLPDGLPEDESADE
                     QRYTAVRRALRPVFVCCQAGAGQLLRHRWGRIIIVTEPADADGNTWRTSRPVLDGLIGF
                     TRSAALELARSGTTVNLVAPADRAADSRAPAHRAAGDDSAGSYADGVAHVTEFLVDERA
                     VGITGQAIRVAARADVPLLRER"
     gene            7651..9234
                     /gene="novL"
                     /note="novobiocic acid synthetase"
     CDS             7651..9234
                     /NRPS_PKS="Domain: AMP-binding (22-419). E-value: 6.8e-71.
                     Score: 230.8. Matches aSDomain:
                     nrpspksdomains_novL_AMP-binding.1"
                     /codon_start=1
                     /gene="novL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     278.1; E-value: 1.9e-84)"
                     /gene_kind="biosynthetic-additional"
                     /note="novobiocic acid synthetase"
                     /product="amide synthetase"
                     /protein_id="AAF67505.1"
                     /sec_met_domain="AMP-binding (E-value: 7.3e-74, bitscore:
                     239.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANKDHAPEHYVTRILAEATLDGARPVVRWRDTVITGTQLDRSVR
                     RVVTALREAGVARDHAVAVLTQVNSPWMLIVRYAAHLVGASVVYITGANHGIVTHELPV
                     ATRVRMLREAGASVLVFDESNAQLAETVDETVRDKLVLCGLGHPASGTVSVDGRPVDDV
                     SVDFTPEAPELAMVLYTSGTTGQPKGVCRSFGSWNAAALRGAAYPRPVFLTMTAVSQTV
                     AMIVDTVLAAGGSVLLRERFDPADFLRDVGEHRVTETFMGVAQLYAILGHPDARTADLS
                     SLRHVLYLGCPASPERLREAAALLPGVLAQSYGSTEAGRITVLRAADHERPELLATVGR
                     AVPGVTIAIRDPETGHDLPVGEIGEVVVHGPEVMAGYVADPEHTARVIRDGWVHTGDFG
                     SVDERGYVRLFGRMREVVKVQDTRVSPTEVEKVLVGCPGVVDACVYGHRGPDLIEELHA
                     AVVLGTEGAPSFDTLRDHVARAMTPTHAPIRFVRWRRFPINNTGKVNRLRVREVSAEAR
                     GDSPDVLVDR"
     aSDomain        7717..8907
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_novL_AMP-binding.1"
                     /evalue="6.80E-71"
                     /label="novL_AMP-binding.1"
                     /locus_tag="novL"
                     /protein_end="419"
                     /protein_start="22"
                     /score="230.8"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="GARPVVRWRDTVITGTQLDRSVRRVVTALREAGVARDHAVAVLTQ
                     VNSPWMLIVRYAAHLVGASVVYITGANHGIVTHELPVATRVRMLREAGASVLVFDESNA
                     QLAETVDETVRDKLVLCGLGHPASGTVSVDGRPVDDVSVDFTPEAPELAMVLYTSGTTG
                     QPKGVCRSFGSWNAAALRGAAYPRPVFLTMTAVSQTVAMIVDTVLAAGGSVLLRERFDP
                     ADFLRDVGEHRVTETFMGVAQLYAILGHPDARTADLSSLRHVLYLGCPASPERLREAAA
                     LLPGVLAQSYGSTEAGRITVLRAADHERPELLATVGRAVPGVTIAIRDPETGHDLPVGE
                     IGEVVVHGPEVMAGYVADPEHTARVIRDGWVHTGDFGSVDERGYVRLFGRMREVVKV"
     CDS_motif       8173..8223
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novL_0001"
                     /evalue="1.80E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="novL"
                     /protein_end="191"
                     /protein_start="174"
                     /score="23.5"
                     /tool="antismash"
                     /translation="AMVLYTSGTTGQPKGVC"
     CDS_motif       8725..8808
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_novL_0002"
                     /evalue="3.90E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="novL"
                     /protein_end="386"
                     /protein_start="358"
                     /score="25.6"
                     /tool="antismash"
                     /translation="PVGEIGEVVVHGPEVMAGYVADPEHTAR"
     gene            9248..10387
                     /gene="novM"
     CDS             9248..10387
                     /codon_start=1
                     /gene="novM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 279.6;
                     E-value: 8e-85)"
                     /gene_kind="biosynthetic-additional"
                     /note="glycosyl transferase"
                     /product="glycosyltransferase"
                     /protein_id="AAF67506.1"
                     /sec_met_domain="MGT (E-value: 8.6e-116, bitscore: 377.6,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLTSLPGIGHLFPMVPLGWALQAAGHTVLVATDREFLPVVTG
                     AGLSATAVLDPVDPVELFKPVEPFGDPLSPAERTGHRCAEAGVRALPAMRALVDVWHPD
                     LVIAEPMELAGPAAATNAGVPWVRHSYGLIPPGPLLSVAAEVLDAELAVLGLSALAKPA
                     RTIDVCPDSLRPSDGVATVPMRYVPYNGPAGVPDWLLAGPPARPRVCLTLGTSLPRRDP
                     HVAPLWRLLLDELVALGQEVVIAIDESHRPLLGHLPDGVRAARIPLCDLLPTCTAIVHH
                     GGSGSTMAAASFGVPQLVVPHFADHFTNAERLTAVGAGLSLPHDTDDLARISAACELIT
                     GDGPHRAISRRLADENARRPTPAVVAEGLAAEQRSMTPA"
     gene            10416..12449
                     /gene="novN"
     CDS             10416..12449
                     /codon_start=1
                     /gene="novN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Carbam_trans_N"
                     /gene_kind="biosynthetic-additional"
                     /note="O-carbamoyltransferase"
                     /product="carbamoyltransferase"
                     /protein_id="AAF67507.2"
                     /sec_met_domain="Carbam_trans_N (E-value: 1.1e-45,
                     bitscore: 146.9, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLILGLNGNVSAAGADVVPNLNELYMHDAAATLVRDGVLVAAVEE
                     ERLNRIKKTTKFPSNAIRECLAAAGAKPADVDAIAYYFPEDFFDDIFQQLYTEHPSVPT
                     RYSREMILERLRVDLGWAAPPDILHYVPHHLAHAMSTYYRSGMREALVVVMDGAGERNC
                     TTIYRSDGAELFEIASYPVPKSLGMFYLYGTRHLGYGFGDEYKVMGLAPYGDPSTYRDV
                     FSTLYSLGPNGTYELIPRGGVVFRMTTILREHGLQPRRRGEPFTQAHMDFAASVQETTE
                     QIAMHVIGYWARSTGLRNLAFGGGVAHNSTLNGRILTSGLFDEVFVHPASHDAGSSEGA
                     ALVVARERGERVWPLPRLTNASLGPDLGDVDSLERTLKSWSPLVDVERPDDIVEATAHL
                     LAAGEAIGWAHGRSEFGPRALGNRSILADARPKENQTRINAMVKKRESFRPFAPVVTAE
                     AAGDYFDLPETVGHHDFMSFVVQVRADRRELLGAVTHVDGSARVQVVTEETNPRFHRLV
                     TRFGELTGTPVLLNTSFNNHAEPIVQSVDDVLTSYLTTSLDVLVIEDFVVRRRTELPLA
                     LEDFTIGFRPVTRLVRRLADVSAGRPGAPEVSHEIYLDHTSGPRATISAAMYELLTHAD
                     GVTPLGSLGIELTGELLTELYDLWQGRFVTVAPVGDGAGSAP"
     gene            12680..13372
                     /gene="novO"
     CDS             12680..13372
                     /codon_start=1
                     /gene="novO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 83.7; E-value:
                     2.4e-25)"
                     /gene_kind="biosynthetic-additional"
                     /note="methyltransferase"
                     /product="methyltransferase"
                     /protein_id="AAF67508.2"
                     /transl_table=11
                     /translation="MKIEAITGSEAEAFHRMGSQASHRYDEFVDLLVGAGIADGQTVVD
                     LCCGSGELEVILSSRFPSLNLVGVDLSEDMVRIAREYAAEQGKALEFRHGDAQLLAGME
                     DLAGKADLVVSRNAFHRLTRLPAAFDTMLRLAKPGGAVLNCSFIHPSDFDESGFRAWVT
                     FLNQRPWDSEMQIVWALAHHYAPRLDDYREALAQAARETPVSEQRVWIDDQGYGVPTVK
                     CFARRAAA"
     gene            13417..14205
                     /gene="novP"
     CDS             13417..14205
                     /codon_start=1
                     /gene="novP"
                     /note="O-methyltransferase"
                     /product="O-methyltransferase"
                     /protein_id="AAF67509.1"
                     /transl_table=11
                     /translation="MAPIVETAKETNSDSSLYLDLMIKVLAGTVYEDPAHRENFSHRDS
                     TYREEVRNEGRDWPANAHTMIGIKRLENIRQCVEDVIGNNVPGDLVETGVWRGGACILM
                     RGILRAHDVRDRTVWVADSFQGIPDVGEDGYAGDRKMALHRRNSVLAVSEEEVRRNFRN
                     YDLLDEQVRFLPGWFKDTLPTAPIDTLAVLRMDGDLYESTWDTLTNLYPKVSVGGYVIV
                     DDYMMCPPCKDAVDEYRAKFDIADELITIDRDGVYWQRTR"
     gene            14235..15206
                     /gene="novQ"
     CDS             14235..15206
                     /codon_start=1
                     /gene="novQ"
                     /gene_functions="biosynthetic (rule-based-clusters) other:
                     orf2_PTase"
                     /gene_kind="biosynthetic"
                     /note="prenyl transferase"
                     /product="ABBA prenyltransferase"
                     /protein_id="AAF67510.2"
                     /sec_met_domain="orf2_PTase (E-value: 6.7e-78, bitscore:
                     252.2, seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPALPMNQEFDRERFRVDLRATAAAIGAPVTPRVTDTVLETFRDN
                     FAQGATLWKTTSQPGDQLSYRFFSRLKMDTVGRAVDAGLLDGTHPTVPIVEDWSDLYGG
                     TPVQSADFDAGRGMAKTWLYFGGLRPAEDILSVPALPAPVQARLKDFLGLGLAHVRFAA
                     VDWRHRSANVYFRGQGPLDTAQFARVHALSGGTPPAADVVAEVLAYVPEDYCVAITLDL
                     HTGAIDRVCFYALKVPKDARPRVPARIATFLEVAPSHDPEECNVIGWSFGRSGDYVKAE
                     RSYTGNMTEILSGWNCFFHGEEGRDHDLRALQDTGSITGGAR"
     misc_feature    14289..14291
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15203..16015
                     /gene="novR"
     CDS             15203..16015
                     /codon_start=1
                     /gene="novR"
                     /note="a-ketoacid-dependent oxygenase"
                     /product="alpha-ketoacid-dependent oxygenase"
                     /protein_id="AAF67511.1"
                     /transl_table=11
                     /translation="MSEALANMPGDDYFRQPPVFDTYAEHRAYLKFRHAVALRHFARLG
                     FDQDGLAGLITVADPEHADTYWANPLAHPFSTITPADLIRVDGDSAETVEGQRRVNIAA
                     FNIHAEIHRARPDVQAVIHLHTVYGRAFSAFARKLPPLTQDACPFFEDHEVFDDFTGLV
                     LAKDDGRRIAKQLRGHKAILLKNHGLVTVGETLDAAAWWFTLLDTCCHVQLLADAAGKP
                     EEIPAEVARLTGRQLGSHLLGWNSYQPLHEAALARDPDLATMEPALPS"
     gene            16012..16878
                     /gene="novS"
     CDS             16012..16878
                     /NRPS_PKS="Domain: NAD_binding_4 (54-156). E-value:
                     1.3e-08. Score: 26.0. Matches aSDomain:
                     nrpspksdomains_novS_NAD_binding_4.1"
                     /codon_start=1
                     /gene="novS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 89.7;
                     E-value: 4e-27)"
                     /gene_kind="biosynthetic-additional"
                     /note="dTDP-4-keto-6-deoxyhexose reductase"
                     /product="dTDP-4-keto-6-deoxyhexose reductase"
                     /protein_id="AAF67512.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6.9e-101,
                     bitscore: 327.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRWLVTGAAGMLGRDLVALLRGLNEPVVAITRHDLDITDRLSV
                     RAVVDRHRPTTIVNCAAWTRFGEAEAGESAALLVNGGGARELAAVCRDRSIRLVHLSTD
                     YVFDGTSRRPYAESAVTSPINAYGRTKQAGEQAVLDLLPDDGTIVRTAWLYGRHGMNFI
                     RKMVRLEQLRETVDVVDDQWGQPTWTVDLAQQIVALVRHGASGVFHGTSAGEATWYDLA
                     RMTFRLLGADPGRVRPVPSDRIAGGELRPRYTVLGHDAWREAGLTPIRHWTTALTQAFP
                     LLNADES"
     aSDomain        16174..16479
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_novS_NAD_binding_4.1"
                     /evalue="1.30E-08"
                     /label="novS_NAD_binding_4.1"
                     /locus_tag="novS"
                     /protein_end="156"
                     /protein_start="54"
                     /score="26.0"
                     /tool="antismash"
                     /translation="TTIVNCAAWTRFGEAEAGESAALLVNGGGARELAAVCRDRSIRLV
                     HLSTDYVFDGTSRRPYAESAVTSPINAYGRTKQAGEQAVLDLLPDDGTIVRTAWLYG"
     gene            16912..17922
                     /gene="novT"
     CDS             16912..17922
                     /NRPS_PKS="Domain: NAD_binding_4 (4-181). E-value: 9.2e-18.
                     Score: 56.1. Matches aSDomain:
                     nrpspksdomains_novT_NAD_binding_4.1"
                     /codon_start=1
                     /gene="novT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     332.1; E-value: 6e-101)"
                     /gene_kind="biosynthetic-additional"
                     /note="dTDP-glucose 4,6-dehydratase"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="AAF67513.1"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.3e-18, bitscore:
                     56.1, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.8e-21,
                     bitscore: 65.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.3e-25, bitscore:
                     80.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFIGSEFVRATLRGTLPGSSGTQVTVLDKLTYSGNV
                     LNLAPIADLRNYRFVRGDICDQDLVDDVVAGHDAIVHFAAETHVDRSIGSAASFVRTNA
                     MGTQVLLEAASRHRLGRFVHISTDEVYGSIPEGAWDEESPVAPNAPYAAAKAAGDLLAL
                     AWHRTHGLDVVVTRCTNNYGPYQYPEKLIPLFTTNVMDGQQVPVYGEGHNRRQWLHVSD
                     HCRAIQLVLLGGRAGEVYHIGGGTELTNLELAEQILKSCGAGWDMVRHVPDRPGHDFRY
                     SLDTTKIRTELGFSPRVAFADGLVETVEWYRDNRAWWEPLKSPDEATGSPGDAGR"
     aSDomain        16924..17454
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_novT_NAD_binding_4.1"
                     /evalue="9.20E-18"
                     /label="novT_NAD_binding_4.1"
                     /locus_tag="novT"
                     /protein_end="181"
                     /protein_start="4"
                     /score="56.1"
                     /tool="antismash"
                     /translation="VTGGAGFIGSEFVRATLRGTLPGSSGTQVTVLDKLTYSGNVLNLA
                     PIADLRNYRFVRGDICDQDLVDDVVAGHDAIVHFAAETHVDRSIGSAASFVRTNAMGTQ
                     VLLEAASRHRLGRFVHISTDEVYGSIPEGAWDEESPVAPNAPYAAAKAAGDLLALAWHR
                     THGLDVVVTRCTNN"
     gene            17974..19236
                     /gene="novU"
     CDS             17974..19236
                     /codon_start=1
                     /gene="novU"
                     /note="C-methyltransferase"
                     /product="C-methyltransferase"
                     /protein_id="AAF67514.2"
                     /transl_table=11
                     /translation="MQDIVRPIDECRVCGHDDWLDVVSFGSTPLAGNLLGDEDDAGGET
                     LFPLDVVVCRRCWLMTLRHVIEPDVLFGHYRYVASDAGSIIQHMRKLVDLCVERIGLTD
                     GDLVVEFGSNTGAHLELFRQAGPRVVGVDPARNLAGVANDRGVETIPAGFTAEVGEEIA
                     TRHGLARLVYGRQCFAHIPDIHEVLNGVSALLAPDGLFFVEVPYLVELLKNNQFDTIFH
                     EHFSYFSLGSLCTLFESHGLRVVDVHTADVHGGSIVVFAAPAAADHEVRPAVAEMLAEE
                     RSQGIAEERTYREFADRTERVRAQIRELVRGVVADGKTVAGYGAPTKGSALLAACGLGH
                     QEIRFCSDTTVLKQGKILPGSRIPIWSPEQAAGHVPDYYLLLAWNYAPEIIDNEKEFLE
                     NGGRFIVPIPEPRVISAESTL"
     gene            19298..20191
                     /gene="novV"
     CDS             19298..20191
                     /codon_start=1
                     /gene="novV"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: SpcDK_cou"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 262.2; E-value:
                     9.4e-80)"
                     /gene_kind="biosynthetic"
                     /note="dTDP-1-glucose synthase; glucose-1-phosphate
                     thymidyl transferase"
                     /product="dTDP-glucose synthase"
                     /protein_id="AAF67515.1"
                     /sec_met_domain="SpcDK_cou (E-value: 7e-205, bitscore:
                     668.9, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGILLAGGTGSRLWPVTRAISKQLIPVFDKPMIYYPLTTLMMAG
                     VREILVITRPDDQRQFRHLLGDGSQLGLRLEYAVQERPEGIAQAFVLGAEFIGDQSVAL
                     VLGDNIFHGAGLGTRLRQYNDPAGARIFAYVVADPKAYGVVEFDEAGRAVSIEEKPARP
                     KSRYAVPGLYFYDNRVLDVVHGLVPSRRGELEITAVNETYLKWGQLRVTTLDRGTAWLD
                     TGTFASLVQASEYVRVVEERQGLKIGCVEEVAWRCGFIGNDQLRDLSRPLLKSGYGRYL
                     LDLLADHEELKEVKPS"
     gene            20188..20811
                     /gene="novW"
     CDS             20188..20811
                     /codon_start=1
                     /gene="novW"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /note="dTDP-4-keto-6-deoxyglucose 3,5-epimerase"
                     /product="dTDP-4-keto-6-deoxyglucose 3,5-epimerase"
                     /protein_id="AAF67516.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 3.3e-60,
                     bitscore: 193.0, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRPLGIEGVWEITPEQRADPRGVFLDWYHVDRFAEAIGRPLRL
                     AQANLSVSVRGVVRGIHFVDVPPGQAKYVTCVRGAVFDVVVDLRVGSPTYGCWEGTRLD
                     DVSRRAVYLSEGIGHGFCAISDEATLCYLSSGTYDPATEHGVHPLDPELAIDWPTGTPL
                     LSPRDQDALLLAEARDAGLLPTYATCQAVTVPSPAPGSVGDPGP"
     gene            21185..23218
                     /gene="gyrB_R"
     CDS             21185..23218
                     /codon_start=1
                     /gene="gyrB_R"
                     /note="DNA gyrase subunit B"
                     /product="resistant DNA gyrase subunit B"
                     /protein_id="AFI47646.1"
                     /transl_table=11
                     /translation="MTSYDTRTATDTPGPQLPGQVGTASYDADAITVLDGLDAVRKRPG
                     MYIGSTGERGLHHLVQELVDNSVDEALAGVADRIDVTVLADGGVRVVDNGRGIPVGMHP
                     VEKRPAVEVVLTVLHAGGKFGGGGYTVSGGLHGVGLSVVNALSARLSAEIWTDGHRWTQ
                     DYRDGAPTAPLVRREATSRTGTSLTFWADGSIFETTDYSFETLARRFQEMAFLNRGLTL
                     TLTDERASARATAATDEVHPDPAAKTVSYRYDGGITDFVAYLNSRKGEPVHPSVVTIAA
                     DDTERLLSAEIALQWNGQYTDSVYSYANAIHTHEGGTHEEGFRTALTTVVNRYARDKKL
                     LREKDANLAGEDIREGLTAIISVKLREPQFEGQTKTKLGNTEVRTFVQKVVHEHLTDWF
                     DRNPNEAADIVRKAVQAATARVAARKARDLTRRKGLLETASLPGKLSDCQSNDPAMSEI
                     FIVEGDSAGGSAKSGRNPQYQAILPIRGKILNVEKARIDRILQNQEIQALISAFGTGMH
                     EDFDIAKLRYHKVILMADADVDGQHINTLLLTVLFRFMRPLIEEGHVYLSRPPLYKIKW
                     SRDHVEYAYSDRERDTLLELGRRDGRRVRDDSIQRFKGLGEMNAEELRVTTMDPDHRVL
                     GRVALDDAAVADDLFSVLMGEDVEARRHFIQRNAKDVRFLDI"
ORIGIN
        1 gtggtcgcgt ctggtcggac agcttcgaaa gggcggggaa acggcgccac tccggtgagg
       61 ccgacggcag gggacgcgac ccccgttgac agcggacaac cgagcgacac cacgtatggc
      121 ggcctggaag tctcggccga gaggaccaga cttcggatcc cgcgggacct ctccttggag
      181 gcctggtgcc gtctcggcgg aaggatcctc gcggtgtgcg attcatcggt gtggtggatc
      241 ggcgactggc tggtgttcgg acagaaccaa tacggtgacc gataccgccg ggcgatgaaa
      301 gagaccaagc tcgactacca gacactgcgc aattacgcct gggtggcgag aaaattcgag
      361 ccgtctcgcc ggcgagacag cctcacgttc caacatcaca tggaagtggc ggctctctcg
      421 gaagccgaac aggaccactg gctcgatttc gcggtccgac tgaattggtc gaggaacgag
      481 ctgcgcaaac agatccgggc cagcttgtcg ggcgaagaag acgacctccg gtgcgaggtc
      541 caactcaacc tccagttgga cgagttacgt ctcgaacggt ggagggaggc ggcgcggggg
      601 agcaatctga ctctgacgga ctggatcctg tccgtcgtgg acggggccgt ttgaccggac
      661 gcactccgat ccatttcgcg gcctcacggc ttcgccgcgt gacggtctcg aagggattgc
      721 gggagatcaa tgcgcacggc cgtgataatc gggaccggaa tgatcggcac atccatcggt
      781 ctggcgctgc ggaagcaagg cgtcgactcc tacctcatgg acaccagtcc cgtcgcactg
      841 cgcatcgccg aagcagtcgg cgccgggacg gccgaggaac cgccggaaac ggtggacctg
      901 gcggtggtcg ccgtaccacc ggtccacgtg gcaccggtga tcgcctccca ccagtcgagg
      961 ggaaccgccc gcttctacgt cgacgtggcc ggtgtgaagg tctccacccg gcgtgaactg
     1021 gacgcactgg gctgtgacct tgccacggtg gtgggcggtc atccgctggt gggacggccg
     1081 gggtcgggcc ccctggcggc gcggggcgac ctgttcgacg gacggccgtg ggcgctcgtc
     1141 cccgcggtgg gaacagacgc cgccgcactg aaccgcgctc tcgaactggt cgccgcctgc
     1201 ggcgcgatac cggtcgtcct ggacgccgag gcgcacgaca gggcgatcgc tctcggcaca
     1261 ctcgtccccc agatcgccct cactctcgtc gccgctcgcc tcacggaggc ggacagtggc
     1321 gcgttacggt tgctgggcag cgtgtggtcg gagatacctc agctcgtcgg ggtcgactcc
     1381 gccacctcgt ggacacaggt cctcgccgcg aacgcggctc cggtcgtggg tgaactggag
     1441 aagctgagcc gggacttggc gagcctgttg gagacgctca gaggtgtcgc cgacggggac
     1501 ggctcgctcg cggagcccga cgggcgactg ctggagttca tccagcgtgg catcgacggc
     1561 tccaaccgcg ttcccggaag gtacgggatc cccacggaga ccgcgctcgc ggacgtcgac
     1621 gtgtccgtgg acgaccggcc ggccgagctg gcccgcctct tcgacgacgt ggccggcgcc
     1681 ggggtggtga tgcgcggcat cgacatctcg cagcggcccg acagccccga ccgtacggtc
     1741 accatttcgg tcaccccgcg cgacgccgag aacctcctgc acgaactgcg ccgcaggaag
     1801 tggccggcga actcctgacg tcgggaaggg cgttgccgcc cggcggtgga tgggcgatga
     1861 acgtgctttg atgctgatga gcgtgccgat ccggaccaga ccattaagtc ctatgggggt
     1921 tacatgacca acagcggcga tgaggagata acgccggctt cgctcaaggc aaccagaaag
     1981 ggggaacggg tctcgatcgg ttcactatta ccgccgtccg aactggtacg gtccggcgaa
     2041 agcaccgaac acattcgagt gctcgccgaa acggacgagg atctgccacc cattgtcgtg
     2101 caccgtggga cccggcgggt cgtcgacgga atgcaccggc tgtgggcggc tcgtttccga
     2161 ggcgacgaat cgatcgaggt cgtattcgtc gacggctccc cggccgatgt gttcgttctc
     2221 gcggtcgagt tgaaccgtgc gcacggcctg ccgctcacgc tggacgagcg caaatccgcc
     2281 gccgcccaga tcatggattc acacccgcac tggtccgacc gcaagatcgc acggaccacc
     2341 ggactggcgg ccagcaccgt cgcgtcgctg aggtcgtcgt ccaccgccgg cacggtcggg
     2401 cgcaggaccg gccaggacgg ccggagccgg cccaacgacg gtacggacgg acggcagcgc
     2461 gccgccgccc tgctggcccg gaatccgaac gcgtcgcttc gcgaggtgac cagagccgcg
     2521 gggatctcgg tcggcaccgc cagcgatgtg cgcgccagac tgcggcgggg ggagccggcg
     2581 ctcaccgccc ggcagcaggc cgtgatgaaa ctgcgccccg ccgcggctca gcggagcggc
     2641 ccggactacg gccgcgtact ggaaaacctg cgcaaggacc cgtcgctgcg cttcaccgac
     2701 ctcggccggc gcctgctccg cctgctcgac ggctccgtcc ccggcagtgt cgagcagatc
     2761 gcccagatcg cggacggcgt gccggaacac tgccggaccg tggtggtcga catggcccgc
     2821 gagtgcgccg ccgcctggca gcatctcgcc gaccagctcg ccgaccggga caccgcctga
     2881 cgttcaactg ctcgaatcat tcggttgaac accaccgcat ggcatttgcc tcttgaaccg
     2941 tcccggtgcg atgcggagga tgtttccggg gcggttgtcg gtgcgagctg tcccgggagt
     3001 cgccttttcg cgcagaattc cccttcggtc atccggggag tacgttccaa tgtcatggag
     3061 acttaagggg gaagtttgtt caacacacgt gcgaacaaag cttctgatca gtcgccgaca
     3121 ataccgacgg aatcggccac cctggccgaa ctctgggagc ggacggtacg aagtcggccg
     3181 agcagcccgg caattgtcac caacggcgag accctgtcct acgacgaggt caacgccagg
     3241 gcgaaccggc tggcacgact gctgctcgac gagggggcgg gcccgggccg tctggtggca
     3301 ctggcgctgc cccgctccag tcatctggtg atcagcgtgc ttgccgtggc caaggccggc
     3361 gcggtgttcc tgccgctgga cgtcaaccac ccgcgggagc ggctctcgta ccaactcgcc
     3421 gatgcccggc ccgcgttgct gtgcaccgtc cgaagcgccg ccgcgagact gccggacggc
     3481 atcgagatgc cgcgggtgct gctggactcg cccgagcgca ccgccgtact cgacgcactg
     3541 cccgacaccg acctgaccga cgacgaacgc ggcggaccgc tcgccgcgac ggacctggcc
     3601 tacgtgatct acacctccgg ctcgacaggc cggccgaaag gcgtcgcgct gaccggcgcc
     3661 gggttgccgg ccctggcagc ggccaaggtc gccgcgatgc gggtcaccgg ggacagccgg
     3721 gtgctccagt tcgcgtcgcc gggcttcgac gcctacctga ccgaactgct ggccgcgttc
     3781 accgccggtg ccactctcgt ggtgccggga acggacacgc tcgccggtga cccgctgcga
     3841 agggccttgc gggacggccg ggtgagccac gctgtgctgc cgcccgcggc ggtcgcgacc
     3901 atgtccccgg acgcggtgcc cgacctgcgc gtgctggtgg tggcgggcga ggcgtgcccg
     3961 gccggcctgg tcgaacggtg ggcgcccggc cgccttctga tcaacgccta cggtccgacc
     4021 gagtgcacgg tgtgcgcgac catgaccggc ccgctcaccc cgacggacga ggtcaccatc
     4081 ggccggccga ttcccggcgt gtccgtgtac atcctcgacg ccgaacgacg cccggccgcg
     4141 cccggagaga tcggcgagtt gtacctcagc ggtgccgggc tggcccaggg ctacctcaac
     4201 agccccgacc tgacggccca gatgttcgta cccaacccgt tcgccgccga cggcgaacgg
     4261 atgtaccgca cgggcgatct ggcctccagg cgggccgacg gcgacatcct cttccacggc
     4321 cggatcgatg atcaggtcga actgcgcgga ttccgcgtcg agttgggaga ggtggagtcc
     4381 gtactcagcc aacatccgga cgtggcacag gcggtggccg cgctgtggac cgatccggcc
     4441 gaggggccgc agttggtgac gtacgtcgtc ccggcacccg gcaccacgcc gtcggcgggc
     4501 gaactgcgtg agcacgccgg ccgcttcctg cccgacttca tggtgccgtc ggcattcacg
     4561 accatcgacg ccgttcccct gactcccggc ggaaagacgg accgggccgg gctgccggat
     4621 ccggtgaaag ccacccagcc tgccggactt ggcccgcgta ctcctgccga gaaggtcctc
     4681 tgtgacatat tccgggacct gttcgacctt gttgagatcg acgtgcgcag taatttcttc
     4741 gaaatgggcg ggaacagcat tctggctgtc gacctcattc agcgagcgca agaagccggc
     4801 ttgacgctca tgccgaggac cgtgatcgac caccccacca tcgagcaact ggccgcgata
     4861 gcgaccctcg aggagtgaga gatgagcacc cgtcccacgg tgtcccccag cgaactcgaa
     4921 cagatcgacc tggcatcacc ggtcctgcac gccgagtacg aactggacga gatcttccgc
     4981 cacctgcgcg ccgatgagcc ggtgtactgg cagcagccac ggaacgagca gcccggcttc
     5041 tgggtgatca gtcgccacgc cgacgtgaac gaggtgtaca aggacaagga gcacttcacg
     5101 acggagcacg gcaacgcgct ggccactttg ctgaccggcg gtgactctgc ctcgggcgcc
     5161 atgctcgccg tcaccgacgg agtgcgccac catcaggtgc gcaacgtgtt gtccaggggc
     5221 ttctcggcgc ggatgctcga cctcatcgcc cacacgctgc aggaaaccgt ggacggtctg
     5281 ctgctggcgg cactggagcg aggcgaatgc gacgccgcgc aggacatcgc ggcggacgtg
     5341 ccactcgggg cgatctgcga cctgctggag attccccacg cggaccggaa gtacctgctc
     5401 ggtctgacct cgcacgcgtg gagcacggac tacgcggacg agcctcccga ggagagctgg
     5461 gtcgccaaga acgagatcct gctgtacttc agcaagctgc tcaaggagcg tcgcggtgga
     5521 gtccgggagg acatggtcag cctgctggcg aactgccgga tcgacggcga tccgctcaag
     5581 gcggccgagc agatggccaa ctgctacggg ctgatgatcg gcggcgacga gaccggcagg
     5641 cacgccatca ccggcacgat cctcgcgttg atccagaacc ccgaccagtg gcgtgcgctg
     5701 aagaacggcg acgtcgatct gaacacggcg accgaggagg ccctgcgctg gaccgtgccg
     5761 tcgctgcacg gaggccggaa ggcgaccgga gacgtcgtga tcaacggccg gcggatcaac
     5821 gccggcgatg tggtcagtgt gtggatctcc tcggccaacc gtgacgagac cgtcttcgac
     5881 gcgccggacg agttcaacct cgcccgcacc ccgaacaagc acttcacctt cgcgtacggc
     5941 tcgcactact gcctcggcca ctacctcggc cggatggagg tctacgccgt gctcgacggg
     6001 ctgcgccggc tggtgggcga cctggagcag atcggcgagg agcgatggat ctactccagc
     6061 atcctgcacg ggatgagctc actgccgatc aggatcacgg gctgaggggc ggggaggcgt
     6121 gcggatgacg agcccggccg atgcgaccac cgaagtcgct gtgtctcagg agtcggtcgc
     6181 catggtcacc ggagccggcc ggggcatcgg cgcggccacg gccgagcgcc tcgccgccga
     6241 gggcatggcg gtgatcgtcg tggaccgcac cgaacaggac acccgggcca cggtcgcggc
     6301 cattcgcacg gccggcggac gggcccgcgg gatcggctgt gacgtcgccg tggcccaggc
     6361 cgtgacggcc gcggtcgcca cggccgtcga ggagttcggc cgcatcgacg tactggtgaa
     6421 ctgcgccggg atcaaccggg accggctgct gctcaccatg ggcgatcagg agtgggacac
     6481 ggtcctggac gtcaacctcg gcggcaccat gcgatgttcg ttcgccgtcg gccggcacat
     6541 gcgccggcag gggcacggcc ggatcatcaa cttcagctcc gtggccgcgc gcggcaatgc
     6601 cggccagacc aactacgcga ccgccaaagg cgcgatcgcc gggttcaccc gtacgctcgc
     6661 ggccgaactg ggcccgcacg gcgtgacggt caacgccatc gcaccgggct tcgtggccac
     6721 gccgatggtg gacgagctgg ccgaacggct cggcggggac cgggactcgg tcatgtcgga
     6781 ggcggcgaag tcctcggcag tgggccggat cgggacgccc gaggaaatcg ccgcgaccgt
     6841 ggtcttcgtc gcccggccgg aatcgggcta cctcaccggc gagaccgttc acgtcgacgg
     6901 cggtcggcca tgacacgagt ggcggtcgtg gccggcggcg gcgagcacac ggggcccgcg
     6961 gtcgcgctca ggctggcggc ggggggcttc gacgtcgccc tgctgggctc cgagttcacg
     7021 tcggccgaca agacggtcag gcgcgtcgag gagtacggca ggcaatgcgt caccgtgcgg
     7081 gccgagttga gcgacgccag atccgtcgcg gtcgccttcg gccgggtacg tacggcgttg
     7141 agcggcccgg ccgtactggt cacctgcgtc ggaccgcagc cgctgccgga cgggttgccc
     7201 gaggacgaga gcgcggacga acagcgctac acggcggtac ggcgggcgct gcgcccggtg
     7261 ttcgtgtgct gccaggccgg ggccggccag ctgctgcgcc accggtgggg acggatcatc
     7321 atcgtcaccg agccggccga cgccgacggg aacacctggc gcaccagccg gccggtgctc
     7381 gacgggctga tcggtttcac ccggtccgcg gcgctggagc tggcgaggtc cgggaccacc
     7441 gtgaacctcg tcgctccggc cgaccgcgcc gccgacagcc gggccccggc ccaccgggcg
     7501 gcgggcgacg acagcgcggg ctcctacgcg gacggggtcg cgcacgtgac ggagttcctg
     7561 gtcgacgagc gagccgtcgg aatcaccggg caggcgatcc gtgtcgccgc ccgggcggac
     7621 gtacctctac ttcgcgaaag gtagccactg gtggcgaaca aggatcacgc accggagcac
     7681 tacgtcaccc gcatcctcgc cgaggcgacc cttgacggcg cgcgaccggt cgtccggtgg
     7741 cgggacacgg tcatcaccgg cacccaactc gaccgatcgg tacggcgcgt cgtgacggca
     7801 ctgcgcgagg caggtgtggc acgcgatcac gcggtggccg tcctgaccca ggtcaacagt
     7861 ccatggatgc tgatcgtccg ctacgccgcg cacctggtgg gcgcgtcggt cgtgtacatc
     7921 accggcgcca accacggcat cgtgacgcac gaactgccgg tggccacccg ggtccggatg
     7981 ctgcgtgaag cgggcgcgtc ggtgctggtg ttcgacgaga gcaacgccca actcgccgag
     8041 accgtcgacg agacggtgcg ggacaagctg gtgctgtgcg gcctcggtca tccggcgtcc
     8101 ggcacggtga gcgtcgacgg ccggcctgtc gatgacgtct cggtggactt cacgcccgag
     8161 gcgcccgagc tggccatggt gctctacacc agcggcacca ccggtcaacc caagggcgtg
     8221 tgccggtcgt tcgggtcgtg gaacgcggcg gcgctccgcg gggcggcgta tccccggccg
     8281 gtcttcctga caatgaccgc ggtgagccag acagtcgcga tgatcgtcga cacggtgctg
     8341 gccgccggcg ggagcgtgct gctgcgcgag aggttcgatc ccgccgactt cctgcgggat
     8401 gtcggagagc accgcgtcac cgagacgttc atgggcgtgg cgcagctcta cgcgatcctc
     8461 gggcacccgg acgctcgtac cgcggacctg tcctcgttgc gccacgtgtt gtatctcggc
     8521 tgccccgcgt caccggaacg cctgcgggag gcggccgcac tgctgcccgg cgtactggcc
     8581 cagtcgtacg gctccaccga ggccggccgg atcacggtgc tccgcgcggc cgaccacgaa
     8641 cgtccggaac tgctggccac cgtgggccgg gcggtgccgg gggtcaccat cgccatccgc
     8701 gacccggaaa caggacacga cctgccggtc ggcgagatcg gcgaggtcgt ggtgcacggc
     8761 ccggaggtca tggccggcta tgtcgccgat cccgagcaca ccgcgcgggt gatccgggac
     8821 ggctgggtgc acaccggcga cttcggttcc gtcgacgaac gcgggtacgt gcggctgttc
     8881 ggccggatgc gcgaggtggt caaggtgcag gacacgcggg tcagtccgac cgaggtggag
     8941 aaggtgctcg tcggctgtcc cggtgtggtc gacgcgtgcg tgtacggcca ccgcgggccg
     9001 gacctcatcg aggaactgca cgccgccgtc gtactgggca ccgagggcgc tccgagcttt
     9061 gacactctgc gcgaccacgt cgcccgggcc atgaccccga cacacgcccc gatccggttc
     9121 gtacggtggc ggcggttccc gatcaacaac accggcaagg tgaatcggct gcgggtccga
     9181 gaggtcagcg ccgaggcccg cggtgacagc ccggacgtcc tggtggacag gtgaggtggg
     9241 tcattcgatg agagtgctgt tgacgagtct gcccggcatc ggccacctgt ttcccatggt
     9301 gccgctgggc tgggcgctcc aggcggccgg gcacaccgtc ctggtcgcca cggaccggga
     9361 gttcctcccg gtggtgaccg gggcgggact gtccgccacg gccgtactgg acccggtcga
     9421 cccggtcgag ctgttcaaac cggtcgaacc gttcggcgat ccgctgagcc cggccgagcg
     9481 gaccgggcac cggtgcgccg aggccggtgt ccgggcgctg cccgccatgc gcgcactcgt
     9541 ggacgtgtgg cacccggacc tggtgatcgc cgagcccatg gagctggccg ggcccgccgc
     9601 ggcgacgaat gccggggtgc cctgggtacg gcactcctac gggctgatcc cgccggggcc
     9661 gctgctgagc gtcgcggccg aggttctgga cgccgaactg gcggtactgg ggctctccgc
     9721 gctggcgaaa ccggcgagga cgatcgacgt gtgccccgac agcctccggc cttcggacgg
     9781 agtggcgacc gtgcccatgc ggtacgtgcc ctacaacggc ccggccggcg tacccgactg
     9841 gctgttggcc gggccccctg cccggccccg ggtctgcctg acgctgggca cgtccctgcc
     9901 ccggcgtgat ccgcacgtgg caccgctgtg gcggctgctg ctggatgaac tggtggccct
     9961 gggccaagag gtggtcatcg ccatcgacga gagccaccgg cccctgctgg gccacctgcc
    10021 cgacggcgtg cgcgccgccc ggatcccgct ctgcgacctg ctgccgacgt gcaccgcgat
    10081 cgtgcaccac ggtggctcgg ggagcaccat ggcggcggcc tccttcggtg tgccgcagct
    10141 ggtggttccg cacttcgcgg accacttcac caacgcggag cgactcaccg ccgtcggcgc
    10201 gggtctgagc ctgccgcacg acaccgacga cctggcacgg atcagcgcgg cctgcgagct
    10261 gatcaccgga gacggcccgc accgcgcgat ctcacgccgt ctcgccgacg agaacgcccg
    10321 ccgaccgacc ccggccgtgg tggccgaggg cctggcggcc gaacaacggt caatgactcc
    10381 cgcgtgaaag cgccgtgctc gcagattgga acgacatgct cattcttggc ctgaacggga
    10441 atgtgtccgc agcgggcgcc gatgtggtgc cgaacctcaa cgagctctac atgcacgacg
    10501 ccgccgccac actggtccgc gacggagttc tcgtggcggc ggtggaggag gagcggctca
    10561 accggatcaa gaagacgacg aaattcccca gcaacgcgat ccgggaatgc ctcgccgccg
    10621 cgggtgcgaa accggcggac gtcgacgcga tcgcctacta cttccccgaa gacttcttcg
    10681 acgacatatt ccagcagctc tacaccgagc atccgagcgt gccgacgcgg tactcgcgcg
    10741 agatgatcct ggagcgtctt cgcgtcgacc tcggctgggc ggctccgccg gacatcctcc
    10801 actacgtgcc gcaccacctg gcccacgcga tgtcgacgta ctaccggtcg ggcatgcgcg
    10861 aggcactggt cgtcgtcatg gacggggcgg gtgagcgcaa ctgcaccacg atctaccggt
    10921 cggacggggc cgagctgttc gagatcgcgt cgtacccggt gccgaagtcg ctcggcatgt
    10981 tctacctgta cgggaccaga cacctcggct acggcttcgg cgacgagtac aaggtgatgg
    11041 gcctcgcccc gtacggcgac ccgtccacct accgcgacgt cttctcgacc ctgtactcgc
    11101 tcggtccgaa cggcacctac gagttgatcc cgcgcggggg agtggtcttc aggatgacca
    11161 cgatcctgcg ggagcacggt ctccaacccc gccgtcgcgg tgagccgttc acccaggcgc
    11221 acatggactt cgcggcgagt gtgcaggaga ccaccgagca gatcgcgatg cacgtgatcg
    11281 gctactgggc acgctccacg ggcctgcgga acctggcctt cggtggcggc gtcgcccaca
    11341 actcgacgct caacggccgc atcctcacct ccggcctgtt cgacgaggtg ttcgtccatc
    11401 cggcgtcgca cgacgccgga tccagcgagg gcgccgcact cgtggtcgcg cgggaacgcg
    11461 gcgaacgcgt atggccgctg ccccggttga cgaacgcgag cctcggcccg gatctgggcg
    11521 acgtcgactc gctggagcgg acgctcaagt cgtggagccc gctcgtcgac gtcgagcgtc
    11581 ccgacgacat cgtcgaggcc accgcgcacc tgctcgctgc cggcgaggcg atcggctggg
    11641 cgcacggccg ctcggagttc gggccgcgcg cgctgggcaa ccgcagcatc ctcgccgacg
    11701 cgcgccccaa ggagaaccag acgcgcatca acgccatggt gaagaagcgc gagagcttcc
    11761 gcccgttcgc cccggtcgtg accgcggagg cggccggtga ctacttcgat ctgccggaga
    11821 ccgtgggaca ccacgacttc atgtcgttcg tcgtgcaggt gcgggcggac cgccgggagt
    11881 tgctcggcgc ggtgacccat gtcgacggca gcgcgcgcgt ccaggtcgtc accgaggaga
    11941 cgaacccgcg attccaccgg ctcgtcacgc gcttcggtga gttgaccggc acccccgtgc
    12001 tgctcaacac ctcgttcaac aaccacgccg agccgatcgt gcagtccgtc gatgacgtcc
    12061 tcacgagcta tctcacgacg agcctcgacg tgctcgtgat cgaggacttc gtggttcgca
    12121 ggcggaccga actgccgctg gcgctggagg acttcaccat cggctttcgc ccggtgacca
    12181 ggctcgtccg ccggctcgcc gacgtgtcgg cgggcaggcc gggcgctccc gaggtctcgc
    12241 acgagatcta cctcgaccac acctccggac cgcgtgcgac gatctcggcc gccatgtacg
    12301 agctgctcac ccacgccgac ggtgtcaccc cgctgggcag cctcggcatc gagctgaccg
    12361 gagagctcct gacagagctg tacgacctgt ggcaggggcg cttcgtcacc gtcgcccccg
    12421 tgggggacgg tgccggatcc gcaccgtgaa tggtgcggat ccgggccggg aatgggccgt
    12481 cgcggccgta caactgccct ttcatttcgg aatacaccgg ccctgtgtcc gtgtaggctc
    12541 aattcaggat ttatcggcgg cggtcggagg aagtcggcga gtgtggaatg tcagccaccg
    12601 ccgacctcaa tttcccccac cgtgatctac gccaatcatg ttcagatcag ctcactgacc
    12661 caacacgagg ggcatcgaga tgaagattga agcgattacg ggatccgagg ccgaagcatt
    12721 tcaccggatg gggtcccagg cgtcccacag gtacgacgaa ttcgtggatc tgcttgtcgg
    12781 ggccggcatc gccgacggcc agaccgtggt cgacctgtgc tgtggctcgg gcgagctgga
    12841 agtcatcctc agctcccggt tcccctcgct gaatctggtc ggtgtcgacc tctcggagga
    12901 catggtccgt atcgcccggg agtacgcggc cgagcagggc aaggcgctcg aattccggca
    12961 cggcgacgcg caactcctgg ccggtatgga ggatctggcc gggaaagcgg acctggtggt
    13021 ctcgcggaac gcgttccacc ggctcacccg gctgccggcg gcgttcgaca ccatgctgcg
    13081 cctggccaag ccgggagggg ccgtcctcaa ctgctccttc atacacccga gcgacttcga
    13141 cgagtccggg ttccgggcgt gggtcacgtt cctcaaccag cggccctggg actcggagat
    13201 gcagatcgtc tgggcgctgg ctcaccatta cgcgccccgg ctcgacgact accgcgaggc
    13261 cctggcccag gcggcccgtg agacgccggt gtccgagcag cgcgtctgga tcgacgacca
    13321 gggatacggc gttcccacgg tcaaatgctt cgcccgccgg gccgccgcct gagcggcgga
    13381 attgtcccga acagagcgcc tggacccgag tgaggggtgg cacctatcgt ggaaaccgcg
    13441 aaggaaacga acagcgactc atcgctgtat ctggacctca tgatcaaagt gctggccggg
    13501 acggtgtacg aggatcccgc gcaccgggag aacttctcgc accgcgattc gacgtaccgg
    13561 gaagaagtcc gcaacgaggg acgcgactgg cccgcgaacg cacacacgat gatcggaatc
    13621 aaacgcctcg agaacatccg gcaatgtgtc gaggacgtca tcggcaacaa cgtacccggc
    13681 gacctcgtgg aaaccggcgt atggcgtggg ggagcctgca tcctcatgcg gggaattctg
    13741 cgcgcccatg acgtgcggga ccgcacagtc tgggtcgccg actccttcca gggcattccc
    13801 gacgtcggtg aggacggcta cgccggcgac cggaagatgg cgctgcaccg gcgaaactcg
    13861 gtgctcgcgg tctccgagga agaggtccgg cgcaacttcc gcaactacga cctgctggac
    13921 gaacaggtcc ggttccttcc cggctggttc aaggacacgc tgcccaccgc gccgatcgac
    13981 acgctcgccg tgctgcggat ggacggggac ctgtacgaat ccacctggga caccctgacc
    14041 aatctctacc cgaaggtgtc cgtcggtggc tatgtcatcg tcgacgacta catgatgtgc
    14101 ccgccgtgca aggacgcggt cgacgaatac cgcgcgaagt tcgacatcgc cgacgaactg
    14161 atcacgatcg accgcgacgg tgtctactgg caacgcaccc ggtaattcac tgtgagttga
    14221 tcacggagga attcatgccc gcactcccga tgaatcaaga attcgaccgc gaacgctttc
    14281 gcgtcgattt acgcgccacc gccgccgcga tcggcgcgcc cgtcaccccc cgtgtcaccg
    14341 acacggtcct cgagaccttc cgtgacaact tcgcccaggg cgccaccctg tggaagacca
    14401 ccagccagcc cggggaccag ctgtcgtacc ggttcttctc ccgtctcaag atggacaccg
    14461 tcggccgggc cgtcgacgcc gggctgctcg acggcacaca tccgaccgtg cccatcgtcg
    14521 aggactggag cgacctctac ggcggcacgc ccgtgcagtc ggccgacttc gacgccgggc
    14581 ggggaatggc caagacctgg ctgtacttcg gcggcctgcg gccggccgag gacatcctct
    14641 ccgtccccgc actgccggcg ccggtacagg cccggctgaa ggacttcctc ggactgggcc
    14701 tggcacatgt ccggttcgcg gcggtggact ggcgccaccg gagtgcgaac gtctacttcc
    14761 gcggtcaagg ccccctggac accgctcagt tcgcccgcgt ccacgccctg tccggcggca
    14821 caccacccgc cgcggatgtc gtggcggagg tcctcgcgta cgtgcccgag gactactgcg
    14881 tcgccatcac cctcgacctg cacaccggcg ccatcgaccg ggtgtgcttc tacgccctga
    14941 aggtccccaa ggacgcgcgg ccacgcgtcc ccgcccgcat cgccacgttc ctcgaggtcg
    15001 cgcccagcca cgacccggag gagtgcaacg tcatcggctg gtcgttcggc cgcagcggcg
    15061 actacgtcaa ggccgaacgc agctacaccg ggaacatgac ggagatcctg tccggctgga
    15121 actgcttctt ccacggcgag gaaggccgcg accacgacct gcgcgcgctt caagacaccg
    15181 gatcgatcac cggaggtgcc cgatgagcga ggctctggcg aacatgcccg gagacgacta
    15241 cttccgtcag ccgccggtgt tcgacaccta cgccgagcac cgcgcctatc tcaagttccg
    15301 gcacgccgtc gcgctgcggc acttcgcccg cctcggcttc gaccaggacg gcctcgccgg
    15361 actgatcacc gtcgccgacc cggaacacgc cgacacctac tgggccaatc cgctggccca
    15421 ccccttctcc accatcacac cggcggacct gatccgcgtc gacggcgaca gcgccgagac
    15481 cgtcgaaggc caacgccggg tcaacatcgc cgcgttcaac atccacgccg agatccaccg
    15541 cgcacgcccc gacgtccagg ccgtcatcca cctgcacacc gtctacggcc gagccttctc
    15601 cgccttcgcc cgcaagctcc ctccgctgac ccaggacgcg tgcccgttct tcgaggacca
    15661 cgaggtgttc gacgacttca cgggtctggt gctcgccaag gacgacgggc gcaggatcgc
    15721 gaaacagctg cgcgggcaca aggcgatcct gctgaagaac cacggtctgg tcaccgtcgg
    15781 ggagacactc gacgcggccg cctggtggtt cacgctcctg gacacctgct gccatgtcca
    15841 gctgctggcg gacgcggccg ggaagccgga ggagatcccc gcggaggtcg cacgcctgac
    15901 gggccggcag ctcggctcgc acctgctggg ctggaacagc taccagcccc tgcacgaggc
    15961 agccctggcc cgtgaccccg acctggcgac catggagccc gcgctcccgt catgacggat
    16021 cgctggctgg tcaccggtgc ggcgggaatg ctcgggcgag atctggtggc gctcctgcga
    16081 gggctgaacg aaccggtggt cgccatcacc cggcacgatc tcgacatcac cgaccgcctc
    16141 tcggtccggg ccgttgtcga caggcaccgg ccgacgacca tcgtcaactg cgccgcctgg
    16201 acacgattcg gcgaggcgga ggccggcgaa tcggcggccc ttctcgtcaa cggaggaggg
    16261 gcccgggagc tggccgcggt atgccgtgat cgatcgatac ggctggtcca cctctccacc
    16321 gattacgtct tcgacggcac gagccgccgc ccctacgccg aaagcgcggt cacgagcccg
    16381 atcaacgcgt acggccggac gaagcaggcc ggcgaacagg cggtgctcga cctgctgccg
    16441 gacgacggca cgatcgtacg aaccgcctgg ctgtacgggc ggcacggcat gaacttcatc
    16501 cgcaagatgg tccggctgga gcagctgcgc gagaccgtgg acgtggtgga cgaccagtgg
    16561 ggccagccga cctggaccgt ggatctggca cagcagatcg tggcactcgt ccggcacggt
    16621 gcgtccggcg tgttccacgg aacgagcgcg ggcgaggcca cctggtacga cctcgcccgc
    16681 atgaccttcc ggctgctcgg cgcggacccc ggacgagtgc gcccggtgcc cagcgaccgg
    16741 atcgccggcg gtgaactgcg gccccggtac acggtgttgg ggcatgacgc ctggcgggag
    16801 gccgggctga caccgatccg gcactggacc accgctctga cgcaggcgtt ccccctgctg
    16861 aacgccgatg aatcgtagta gtcctcgacc gagagaaagg aggggccgca gatgcgaatt
    16921 ctggtgacgg gcggcgccgg cttcatcggc tcggaattcg tccgggccac cttgcgcgga
    16981 actctgccgg gctcatcggg aactcaggtc accgttctgg acaagttgac gtactccggc
    17041 aacgtgctga acctcgcgcc gatcgcggac ctgcgcaact accgtttcgt gcggggcgac
    17101 atctgtgatc aggacctggt ggacgacgtg gtcgccggtc acgacgcgat cgtgcacttc
    17161 gccgccgaga cacatgtgga ccgctcgatc ggcagcgccg cctcgttcgt ccgcacgaac
    17221 gcgatgggca cccaggtact gctcgaagcg gcctcccgcc accggctggg acggttcgtt
    17281 cacatctcga ccgacgaggt gtacggatcg atccccgagg gcgcctggga cgaggagtcc
    17341 ccggtggccc cgaacgcccc gtacgcggcg gccaaggcgg cgggagacct gctggcgctg
    17401 gcctggcacc ggacccacgg gctcgacgtc gtggtcacca ggtgcaccaa caactacggg
    17461 ccgtaccagt atccggagaa gctgatcccg ctgttcacga ccaacgtgat ggacggtcag
    17521 caggtcccgg tgtacggcga gggccacaac cgccggcagt ggctgcacgt ctcggaccac
    17581 tgccgcgcca tccagctggt gctcctcggt ggccgggccg gggaggtcta ccacatcggc
    17641 ggtggcaccg agttgaccaa tctcgaactg gccgaacaga tcctgaagtc ctgcggtgcc
    17701 ggctgggaca tggtccggca cgtgccggac aggccggggc acgatttccg ctactccctg
    17761 gacaccacca agatccgtac agaactcggt ttctcgcccc gggtcgcgtt cgcggacggg
    17821 ctggtggaga ccgtggagtg gtatcgcgac aaccgggcct ggtgggaacc gctcaagagt
    17881 cccgacgaag ccacgggttc acccggcgac gccggcagat gacggcgtga ccgggaaagg
    17941 ccggcgggtt tcgtccatga ggggaaggaa gaaatgcagg acatagtgcg gcccatcgac
    18001 gagtgccggg tgtgcggaca cgacgattgg ctcgatgtcg tctcgttcgg gtcgacgcca
    18061 ctggccggaa acctgctcgg cgacgaagac gacgcggggg gcgagaccct gttcccgctg
    18121 gacgtcgtgg tgtgccggcg atgctggctg atgacgctgc gccatgtcat cgaaccggac
    18181 gtcctcttcg gtcactaccg ttacgtcgcc tcggacgcgg gctcgatcat ccagcacatg
    18241 cggaagctcg tcgacctgtg tgtcgagcgg atcggactga ccgacggaga cctcgtcgtg
    18301 gagttcggca gcaacaccgg cgcgcatctg gagctgttcc ggcaggccgg cccccgggtg
    18361 gtcggcgtcg atcccgcgcg caatctcgcg ggtgtcgcca acgaccgcgg cgtggaaacg
    18421 atccccgccg gtttcaccgc cgaagtcggt gaggagatcg cgaccaggca cggcctggca
    18481 cgactggtgt acgggcgcca gtgcttcgcc catatcccgg acatccacga agtcctcaac
    18541 ggggtatcgg ccctgctggc tccagacggt ctgttcttcg tggaagttcc ctatctggtg
    18601 gaactgctca agaacaatca gttcgacacc atcttccacg aacacttctc ctacttttcg
    18661 ctcggctccc tgtgcacgct gttcgagtcg cacggcctgc gcgtcgtgga cgtccatacg
    18721 gccgatgtgc acggcggctc gatcgtggtc ttcgccgccc cggccgccgc cgaccacgag
    18781 gtgcggccgg ccgtcgccga gatgctcgcg gaagagcgga gccagggcat cgcggaggag
    18841 cggacctacc gggagttcgc cgatcgtacg gaacgggtgc gcgcacagat ccgggaactg
    18901 gtacgcggcg tggtggcgga cggcaagacc gtggcgggat acggcgcacc gaccaagggc
    18961 agcgcactgc tggccgcctg cgggctcgga catcaggaga tccggttctg cagcgacaca
    19021 accgttctca agcaggggaa aatacttccg gggtccagaa ttccgatctg gtcaccggaa
    19081 caggcggccg gccatgtacc ggactactac ctgctgttgg cctggaacta cgcaccggag
    19141 atcatcgaca acgagaagga attcctggag aacggcggcc gattcatcgt tcccataccc
    19201 gaaccgcggg tgatatcggc ggagtcgacg ctgtgacatc gaaggccgcg ccgacggcga
    19261 ggttcagatg gtgccggatc gccgaggggg tcgctggttg aggggaatcc tgctcgcggg
    19321 cggtaccggc tccaggctgt ggccggtcac ccgcgccatc tccaagcagc tgataccggt
    19381 cttcgacaag ccgatgatct actacccgct gaccacgctg atgatggccg gcgtacgcga
    19441 gatactcgtg atcacgcgcc ccgacgacca gcgccagttc cgtcatctcc tcggcgacgg
    19501 ctcgcaactg ggcctgcgcc tcgagtacgc cgtccaggag cggcccgagg gcatcgcgca
    19561 ggcgttcgtc ctgggcgccg agttcatcgg cgaccagtcg gtggccctgg tcctcgggga
    19621 caacatcttc cacggcgcgg gcctgggaac ccggctgcgg cagtacaacg accccgccgg
    19681 ggcccggatc ttcgcctacg tcgtggccga ccccaaggcg tacggggtgg tggagttcga
    19741 cgaggccgga agggccgtct ccatagagga gaagccggcg cgtcccaagt cgcggtacgc
    19801 cgtaccgggg ttgtacttct acgacaaccg ggtgctggat gtcgtccacg gcctggtgcc
    19861 gagccggcgc ggcgaactgg agatcaccgc cgtcaacgaa acgtatctga agtggggcca
    19921 gttgcgggtc accacgctcg accggggcac cgcctggctg gacacgggaa cgttcgcctc
    19981 cttggtccag gcatcggagt acgtacgagt cgtggaggaa cggcagggcc tcaagatcgg
    20041 ctgcgtggag gaggtcgcct ggcgctgcgg cttcatcggg aacgaccagt tgcgggatct
    20101 cagccgcccg ctgctcaaga gcggctacgg ccggtacctc ctcgatctgc tcgccgatca
    20161 cgaggagttg aaggaggtga agccgtcgtg agacttcgcc cgctcggtat cgagggtgtc
    20221 tgggagatca cccccgagca gcgcgccgat ccgcgggggg tcttcctgga ctggtatcac
    20281 gtcgaccggt tcgccgaggc gatcggccgc cccctgcggc tggcccaggc caatctgtcg
    20341 gtgtccgtcc gcggggtggt gcgcggcatc cacttcgtcg atgtgccgcc ggggcaggcc
    20401 aagtacgtga cgtgtgtgcg cggcgcggtg ttcgacgtgg tggtggacct gcgcgtcggc
    20461 tcgccgacgt acgggtgctg ggaaggcacc cggctcgacg atgtcagccg tcgtgccgtc
    20521 tacctctcgg agggcatcgg gcacggcttc tgcgcgatct cggacgaggc cacgctgtgc
    20581 tatctgtctt cggggaccta cgacccggcg accgagcacg gtgtgcaccc gctcgatccc
    20641 gaactggcca tcgactggcc caccgggacg ccgctgctgt ccccccgcga ccaggacgcg
    20701 ctcctgctcg ccgaagcccg ggacgccggc ctgttgccga cctacgcgac ctgtcaggcc
    20761 gtcacggtgc cttcaccggc gccgggttcg gtcggagacc cgggcccgtg atctgacgca
    20821 gcgcgactgg cgactgcgga gggtcatgtc ggaaatagtg tccgggacgc tgtccggcaa
    20881 ggcgtcaggg aacccttcag gcggccctct cccgtctttt cgacagggga aggcaggggg
    20941 gatcgactta tgtggtgcgg gagccgcacg gcggcgcgca gaggtgctct cgttccggcg
    21001 gcaaggggtg gcgtcggtat tgtcttcagc gtcccgatgg tcggcggcgg ccggcgtccc
    21061 gagggtttcg cgagccccgg ggcccaggtc gggctgccgt gccgcgcctc tcccccccag
    21121 ttctccggct gcttcccgca cgtggtgcgg gagccgggtc tgccatgccc gaaagagagt
    21181 ttccgtgact tcttacgaca cccgcaccgc caccgacacc cccggacccc aactgcccgg
    21241 ccaggtgggg acggcgtcgt acgacgccga cgcgatcacc gtgctggacg gcctggacgc
    21301 cgtacgcaag cggcccggga tgtacatcgg ctccacgggg gagcgggggc tccatcacct
    21361 ggtgcaggaa ctcgtggaca actcggtgga cgaggcactc gcgggggtgg ccgaccggat
    21421 cgacgtgacg gtcctggccg acggcggggt gcgggtggtc gacaacggcc gcggcatccc
    21481 ggtggggatg cacccggtgg agaagcggcc ggccgtcgag gtcgtactga ccgtgctgca
    21541 cgcgggcggg aagttcgggg gcggcgggta cacggtctcc ggcggactgc acggcgtggg
    21601 tctgtcggtg gtcaacgccc tgtcggccag gctgtcggcg gagatctgga cggacggcca
    21661 ccgctggacg caggactacc gggacggcgc tcccaccgcc ccactggtcc gccgggaggc
    21721 cacctcccgc acgggcacct cactgacctt ctgggcggac ggctccatct tcgagaccac
    21781 cgactactcc ttcgagacgc tggccaggcg tttccaggag atggccttcc tcaaccgtgg
    21841 gctcacgctg accctcaccg acgaacgggc ctccgcgcgc gccacggccg cgaccgacga
    21901 ggtccacccg gacccggcgg cgaagacggt ctcctaccgc tacgacggcg gcatcaccga
    21961 cttcgtcgcg tatctcaact cccgcaaggg cgaaccggtc catccctcgg tcgtcaccat
    22021 cgccgccgac gacacggagc ggctgctgtc ggccgagatc gcgctccagt ggaacggcca
    22081 gtacaccgac agcgtgtact cgtacgccaa cgcgatccac acccacgagg gcggcaccca
    22141 cgaggagggc ttccgtacgg ccctgaccac cgtggtcaac cgctacgcgc gggacaagaa
    22201 gctgctgcgg gagaaggacg cgaacctcgc cggcgaggac atccgtgagg ggctgaccgc
    22261 gatcatctcg gtcaagctca gagaaccgca gttcgagggc cagaccaaga ccaaactcgg
    22321 caacacggag gtgcgcacct tcgtccagaa ggtcgtccac gagcatctga ccgactggtt
    22381 cgaccgcaac ccgaacgagg ccgcggacat cgtgcgcaag gccgttcagg ccgccacggc
    22441 ccgggtcgcg gcccgtaagg cgcgggatct gacccgccgt aagggcctgc tggagacggc
    22501 gtcgctgccg ggcaagctgt cggactgtca gtcgaacgac ccggcgatgt cggagatctt
    22561 catcgtcgag ggagactccg ccggcggctc ggccaaatcc ggccgcaatc cgcagtacca
    22621 ggcgatcctc ccgatccggg ggaagatcct caatgtcgag aaggcgcgga tcgacaggat
    22681 tttgcagaac caggagatcc aggcgctcat ctccgcgttc ggcacgggta tgcacgagga
    22741 cttcgacatc gccaagctcc gctaccacaa ggtcatcttg atggcggacg ccgacgtcga
    22801 cggccagcac atcaacaccc tgctgctgac cgtcctgttc cgcttcatgc ggccactgat
    22861 cgaggagggg cacgtctacc tctcgcgccc gccgctctac aagatcaagt ggagccggga
    22921 ccacgtcgag tacgcctact ccgaccgcga acgcgacacg ctgctggaac tgggccgtcg
    22981 ggacggccgc agggtcaggg acgactccat ccagcgcttc aagggcctcg gcgagatgaa
    23041 cgccgaggaa ctgcgcgtca ccaccatgga ccccgaccac cgggtgctgg ggcgggtcgc
    23101 cctcgacgac gcggccgtcg ccgacgacct cttctcggtt ctgatgggtg aggacgtgga
    23161 agcccgccgc cacttcatcc agcgcaacgc caaggacgtc cgcttcctcg acatctga
//
