BGC0000834: cathomycin biosynthetic gene cluster from Streptomyces niveus
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Location: 4,859 - 28,076 nt. (total: 23,218 nt).
This entry is originally from NCBI GenBank AF170880.4.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Saccharide
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000834
Short description cathomycin biosynthetic gene cluster from Streptomyces niveus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide (hybrid/tailoring)
  • Other (Aminocoumarin)
Loci NCBI GenBank: AF170880.4
Compounds
  • cathomycin
Species Streptomyces niveus [taxonomy]
References
Chemical products information
cathomycin
Copy SMILES
C31H36N2O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF67498.1
  • novE
4859 - 5512 (+) regulatory protein NovE
  • Regulation
Heterologous expression
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  • AAF67499.1
  • novF
5588 - 6676 (+) prephenate dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAF67500.1
  • novG
6782 - 7738 (+) regulatory protein CloG
  • Regulation
Heterologous expression
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  • AAF67501.2
  • novH
7934 - 9736 (+) peptide synthetase-like protein
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • AAF67502.1
  • novI
9740 - 10963 (+) cytochrome P450
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • AAF67503.1
  • novJ
10983 - 11771 (+) b-ketotyrosyl-reductase
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • AAF67504.1
  • novK
11768 - 12502 (+) b-ketotyrosyl-reductase
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • AAF67505.1
  • novL
12509 - 14092 (+) amide synthetase
  • Scaffold biosynthesis
Activity assay
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  • AAF67506.1
  • novM
14106 - 15245 (+) glycosyltransferase
  • Scaffold biosynthesis
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Heterologous expression
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  • AAF67507.2
  • novN
15274 - 17307 (+) carbamoyltransferase
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • AAF67508.2
  • novO
17538 - 18230 (+) methyltransferase
  • Tailoring (Methylation)
Activity assay
Heterologous expression
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  • AAF67509.1
  • novP
18275 - 19063 (+) O-methyltransferase
  • Tailoring (Methylation)
Activity assay
Heterologous expression
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  • AAF67510.2
  • novQ
19093 - 20064 (+) ABBA prenyltransferase
  • Scaffold biosynthesis
Activity assay
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  • AAF67511.1
  • novR
20061 - 20873 (+) alpha-ketoacid-dependent oxygenase
  • Scaffold biosynthesis
Heterologous expression
Sequence-based prediction
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  • AAF67512.1
  • novS
20870 - 21736 (+) dTDP-4-keto-6-deoxyhexose reductase
  • Scaffold biosynthesis
Heterologous expression
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  • AAF67513.1
  • novT
21770 - 22780 (+) dTDP-glucose 4,6-dehydratase
  • Scaffold biosynthesis
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  • AAF67514.2
  • novU
22832 - 24094 (+) C-methyltransferase
  • Scaffold biosynthesis
Heterologous expression
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  • AAF67515.1
  • novV
24156 - 25049 (+) dTDP-glucose synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAF67516.1
  • novW
25046 - 25669 (+) dTDP-4-keto-6-deoxyglucose 3,5-epimerase
  • Scaffold biosynthesis
Heterologous expression
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  • AFI47646.1
  • gyrB_R
26043 - 28076 (+) resistant DNA gyrase subunit B
  • Resistance/immunity
Heterologous expression
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Saccharide-specific information
Subclass hybrid/tailoring
Sugar-encoding genes
  • novS, novT, novU, novV, novW
Glycosyltransferases
novM
Specificity: L-noviose
Evidence:
  • Activity assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 6BNBMTTKZLI3ZE3JTCJWEZIV, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove duplicated citations
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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