LOCUS       BGC0000836             15022 bp    DNA     linear   BCT 31-JAN-2014
DEFINITION  Escherichia coli CFT073, complete genome.
ACCESSION   BGC0000836
VERSION     BGC0000836
KEYWORDS    .
SOURCE      Escherichia coli CFT073
  ORGANISM  Escherichia coli CFT073
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
COMMENT     On or before Jan 19, 2006 this sequence version replaced
            AE016755.1, AE016756.1, AE016757.1, AE016758.1, AE016759.1,
            AE016760.1, AE016761.1, AE016762.1, AE016763.1, AE016764.1,
            AE016765.1, AE016766.1, AE016767.1, AE016768.1, AE016769.1,
            AE016770.1, AE016771.1, AE016772.1.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:17:44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15022
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1230)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (83-408). E-value:
                     2.1e-46. Score: 150.5. Matches aSDomain:
                     nrpspksdomains_c1186_PKS_KS.1"
                     /codon_start=1
                     /function="putative enzyme; Fatty acid biosynthesis: Fatty
                     acid and phosphatidic acid biosynth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 298.5; E-value:
                     1.4e-90)"
                     /gene_kind="biosynthetic"
                     /locus_tag="c1186"
                     /note="Escherichia coli O157:H7 ortholog: z4866"
                     /product="Putative beta-ketoacyl-ACP synthase"
                     /protein_id="AAN79648.1"
                     /sec_met_domain="APE_KS1 (E-value: 1.8e-207, bitscore:
                     679.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRVVITGMGGVTAFGENWQDVSARLLAYENAVRKMPEWQVYDG
                     LHTLLGAPVDDFTLPEHYTRKRIRAMGRVSQMSTRASELALEQAGLIGDPILTSGETGI
                     AYGSSTGSTGPVSEFATMLTEKHTNNITGTTYVQMMPHTTAVNTGLFFGLRGRVIPTSS
                     ACTSGSQAIGYAWEAIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSP
                     FDENRDGLVIGEGAGTLILEELEHAKARGATIYGEIVGFATNCDAAHITQPQRETMQYC
                     MEQSLKIAGLSAQDIGYISAHGTATDRGDMAESLATATIYGDNVPVSSLKSYFGHTLGA
                     CGALEAWMSLQMMREGWFAPTLNLNKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGI
                     NTSIIIKRWP"
     protocluster    1..15022
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:3597]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..3597
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..15022
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..15022
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000836"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15022
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1230)
                     /locus_tag="c1186"
     aSDomain        complement(7..981)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_c1186_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.10E-46"
                     /label="c1186_PKS_KS.1"
                     /locus_tag="c1186"
                     /protein_end="408"
                     /protein_start="83"
                     /score="150.5"
                     /tool="antismash"
                     /translation="LALEQAGLIGDPILTSGETGIAYGSSTGSTGPVSEFATMLTEKHT
                     NNITGTTYVQMMPHTTAVNTGLFFGLRGRVIPTSSACTSGSQAIGYAWEAIRHGYQTVM
                     VAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSPFDENRDGLVIGEGAGTLILEELEH
                     AKARGATIYGEIVGFATNCDAAHITQPQRETMQYCMEQSLKIAGLSAQDIGYISAHGTA
                     TDRGDMAESLATATIYGDNVPVSSLKSYFGHTLGACGALEAWMSLQMMREGWFAPTLNL
                     NKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGINTSIIIKRW"
     gene            complement(1227..1958)
                     /locus_tag="c1187"
     CDS             complement(1227..1958)
                     /EC_number="1.1.1.100"
                     /NRPS_PKS="Domain: PKS_KR (3-158). E-value: 4.5e-18. Score:
                     57.6. Matches aSDomain: nrpspksdomains_c1187_PKS_KR.1"
                     /codon_start=1
                     /function="enzyme; Fatty acid and phosphatidic acid
                     biosynthesis"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     213.2; E-value: 6.9e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="c1187"
                     /note="Escherichia coli K-12 ortholog: b1093; Escherichia
                     coli O157:H7 ortholog: z4865"
                     /product="3-oxoacyl-[acyl-carrier protein] reductase"
                     /protein_id="AAN79649.1"
                     /sec_met_domain="adh_short (E-value: 7.4e-38, bitscore:
                     120.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRSVLVTGASKGIGRAIACQLAADGFNIGVHYHRDAAGAQETLN
                     AIVANGGNGRLLSFDVANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDW
                     DAVIHTNLDSFYNVIQPCIMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGIIGA
                     TKALAIELAKRKITVNCIAPGLIDTGMIEMEESALKEAMSMIPMKRMGQAEEVAGLASY
                     LMSDIAGYVTRQVISINGGML"
     aSDomain        complement(1485..1949)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_c1187_PKS_KR.1"
                     /evalue="4.50E-18"
                     /label="c1187_PKS_KR.1"
                     /locus_tag="c1187"
                     /protein_end="158"
                     /protein_start="3"
                     /score="57.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SVLVTGASKGIGRAIACQLAADGFNIGVHYHRDAAGAQETLNAIV
                     ANGGNGRLLSFDVANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAV
                     IHTNLDSFYNVIQPCIMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKA"
     CDS_motif       complement(1491..1553)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_c1187_0002"
                     /evalue="3.30E-09"
                     /label="PKSI-KR_m4"
                     /locus_tag="c1187"
                     /protein_end="156"
                     /protein_start="135"
                     /score="29.3"
                     /tool="antismash"
                     /translation="ITLSSVSGVMGNRGQVNYSAA"
     CDS_motif       complement(1887..1949)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_c1187_0001"
                     /evalue="3.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="c1187"
                     /protein_end="24"
                     /protein_start="3"
                     /score="13.3"
                     /tool="antismash"
                     /translation="SVLVTGASKGIGRAIACQLAA"
     gene            complement(1958..2422)
                     /locus_tag="c1188"
     CDS             complement(1958..2422)
                     /codon_start=1
                     /locus_tag="c1188"
                     /note="Escherichia coli O157:H7 ortholog: z4864"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79650.1"
                     /transl_table=11
                     /translation="MSHYLSPGAYLPHDAPMLLLEDVVSVSDDSAVCRVTVSPSGVLAP
                     FLDPDGNLPGWFALELMAQTVGVWSGWHRHQQGKNSIELGMILGARELLCTAGILPAGQ
                     TLTITVKLLMQDDRFGSFECSINDGEATGRINTFQPTAEELTTLFQQGAS"
     gene            complement(2419..3597)
                     /locus_tag="c1189"
     CDS             complement(2419..3597)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (141-389). E-value:
                     2.7e-36. Score: 117.2. Matches aSDomain:
                     nrpspksdomains_c1189_PKS_KS.1"
                     /codon_start=1
                     /function="putative enzyme; Fatty acid biosynthesis: Fatty
                     acid and phosphatidic acid biosynth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 209; E-value:
                     2e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="c1189"
                     /note="Escherichia coli O157:H7 ortholog: z4863"
                     /product="Putative 3-oxoacyl-[ACP] synthase"
                     /protein_id="AAN79651.1"
                     /sec_met_domain="APE_KS2 (E-value: 2.6e-161, bitscore:
                     527.3, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDMIYISAVGMINALGNNLDEIATNLTRGVAPGMRPRAGWLQGH
                     PQAVLAGVDGELPLIPEKFAAHRSRNNQILLAALAQLQPQVDDAIAKYGRERIAIVLGT
                     STSGLHEGDTHVNLRTHGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSA
                     RAIISGRRLIEAGLVDAAIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGE
                     GAGLMLLTREPQPIALLGVGESSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYI
                     NLHGTATQLNDQIESMVVNALFGERVPCSSTKHLTGHTLGAAGITEAAISMLILQRDLP
                     LPAQDFSLSPRDPTLPPCGIIEKPQPLARPVILSNSFAFGGNNASILLGRVS"
     aSDomain        complement(2431..3174)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_c1189_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.70E-36"
                     /label="c1189_PKS_KS.1"
                     /locus_tag="c1189"
                     /protein_end="389"
                     /protein_start="141"
                     /score="117.2"
                     /tool="antismash"
                     /translation="LSHWLALDGPAYTLSTACSSSARAIISGRRLIEAGLVDAAIVGGA
                     DTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLGVGESS
                     DAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESMVVNALFG
                     ERVPCSSTKHLTGHTLGAAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEK
                     PQPLARPVILSNSFAFGGNNASILLG"
     CDS_motif       complement(3103..3150)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_c1189_0001"
                     /evalue="1.50E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="c1189"
                     /protein_end="165"
                     /protein_start="149"
                     /score="14.2"
                     /tool="antismash"
                     /translation="GPAYTLSTACSSSARA"
     gene            complement(3590..4174)
                     /locus_tag="c1190"
     CDS             complement(3590..4174)
                     /codon_start=1
                     /locus_tag="c1190"
                     /note="Escherichia coli O157:H7 ortholog: z4862"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79652.1"
                     /transl_table=11
                     /translation="MIKSTFWRALALTATLILTGCSHSQPEQEGRPQAWLQPGTLITLP
                     APGISPAVNSQQLLTGSFNGKTQSLLVMLNAEDQKITLAGLSSVGIRLFLVTYDAKGLR
                     AEQSIVVPQLPPASQVLADVMLSHWPISAWQPQLPTGWTLRDNGDKRELRNASGKLVTE
                     ITYLNRQGKRVPISIEQHVFKYHITIQYLGD"
     gene            complement(4171..6489)
                     /locus_tag="c1191"
     CDS             complement(4171..6489)
                     /codon_start=1
                     /locus_tag="c1191"
                     /note="Escherichia coli O157:H7 ortholog: z4861"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79653.1"
                     /transl_table=11
                     /translation="MTNTNVLPPSKRPALLWGLVCLVMAAALLILLPQSRLNSSVLAML
                     PKQVMGDIPPALNDGFMQRLDRQLVWLVSPGKEANPRVAQEWLTLLQKSAALGDVKGPM
                     DAASQQSWGAFFWQHRNGLIDPDTRARLQNGGEAQAQWILSQLYSAFSGVSGKELQNDP
                     LMLMRGSQLAMAKNGQRLRLMDGWLVTQDPQGNYWYLLHGELAGSSFDMQQTHQLITTL
                     NTLEKDLKTRYPQAQLLSRGTVFYSDYASQQAKQDISTLGVATLLGVILLIVAVFRSLR
                     PLLLCVISIGIGALAGTVATLLIFGELHLMTLVMSMSVIGISADYTLYYLTERMVHGND
                     VSPWQSLAKVRNALLLALLTTVAAYLIMMLAPFPGIRQMAIFAAIGLSASCLTVLFWHP
                     WLCRGLPVRPVPAMALMLRWLAAWRRNKKLSRGLSVALALFSLAGMSMLRVDDDISQLQ
                     ALPQHILAQEKAITALTGQSVDQKWFVVYGDSPQQTLRRLEKFTTSLEKAKKDGLISKY
                     RTIPLNSLARQEEDLHLLTTAAPTVTKALQNAGLTTVNPDLNAMPVKVDEWLASPASEG
                     WRLLWLTLENGASGVLVPVEGVKNSAALQEISSYYPCGIAWVDRKNTFDELFALYRYVL
                     TGLLLVALAVIACGAVARLGWRKGFISLVPSVLSLGCGLAVLAISGQAVNLFSLLALVL
                     VLGIGINYTLFFSNPRGTPLTSLLAITLAMLTTLLTLGMLVFSATQAISSFGIVLVSGI
                     FTAFLLSPLAMPDKKRTKK"
     gene            complement(6458..7063)
                     /locus_tag="c1192"
     CDS             complement(6458..7063)
                     /codon_start=1
                     /locus_tag="c1192"
                     /note="Escherichia coli O157:H7 ortholog: z4860"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79654.1"
                     /transl_table=11
                     /translation="MKFLPLLALLISPFVSALTLDDLQQRFTEQPVIRAHFDQTRTIKD
                     LPQPLRSQGQMLIARDQGLLWDQTSPFPMQLLLDDKRMVQVINGQPPQIITAENNPQMF
                     QFNHLLRALFQADRKVLEQNFRVEFADKGEGRWTLRLTPTTTPLDKIFNTIDLAGKTYL
                     ESIQLNDKQGDRTDIALTQHQLTPAQLTDDEHQRFAAQ"
     gene            complement(7060..7482)
                     /locus_tag="c1193"
     CDS             complement(7060..7482)
                     /codon_start=1
                     /locus_tag="c1193"
                     /note="Escherichia coli O157:H7 ortholog: z4859"
                     /product="Hypothetical protein"
                     /protein_id="AAN79655.1"
                     /transl_table=11
                     /translation="MLNDPRFTAEVELTIPFHDVDMMGVAWHGNYFRYFEVAREALLNQ
                     FNYGYRQMKESGYLWPVVDARVKYRHALTFEQRIRVRAHIEEFENRLRIGYQIFDAETG
                     KRATTGYTIQVAVDEQSRELCFVSPDILFERMGVKP"
     gene            complement(7486..9108)
                     /locus_tag="c1194"
     CDS             complement(7486..9108)
                     /codon_start=1
                     /function="putative"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 70.7; E-value: 2.5e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="c1194"
                     /note="Escherichia coli O157:H7 ortholog: z4858"
                     /product="Putative enzyme"
                     /protein_id="AAN79656.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.2e-18,
                     bitscore: 56.5, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMPGVLARLKPFNLPCIVVDDGSDAATQQQLDNLVSEQPGVTLIR
                     LAENAGKGAAVMRGLQAAADAGFSHAVQVDADGQHAIEDIPKLLALAEQHPAALISGQP
                     IYDDSIPRSRLYGRWITHVWVWIETLSLQLKDSMCGFRVYPVAPTLQLAKRATIGKRMD
                     FDTEVMVRLYWQGNTSYFVPTRVTYPLDGLSHFDALKDNVRISLMHTRLFFGMLPRIPS
                     LLMCHSSSHWARQSEVKGLWGMRLMLLVWRLLGRTAFTALLYPVVGVYWLTAARARKAS
                     QDWLARVRQQQPQAAKINSYQHFLRFGNAMLDKIASWRGELQLGRDVLFAPGAEAALDV
                     RDPRGKLLLASHLGDVEVCRALAKIQGYKTINALVFSENAQRFKQIMQEMAPQAGINLM
                     PVTDIGPETAILLKEKLDNGEWVAIVGDRIAVNPQRGGDWRVCWSPFMGQPAPFPQGPF
                     ILASILRCPVNLIFALRQHGKLHIHCETFADPLLLPRGERQQALQNAIDHYAARLEHYA
                     LQSPLDWFNFFDFWQLPEIQDKE"
     gene            complement(9080..9202)
                     /locus_tag="c1195"
     CDS             complement(9080..9202)
                     /codon_start=1
                     /locus_tag="c1195"
                     /product="Hypothetical protein"
                     /protein_id="AAN79657.1"
                     /transl_table=11
                     /translation="MTPATPPVAGRSAYVGKLFSLRVDPLLQPRRDDAGRAGAS"
     gene            complement(9153..9530)
                     /locus_tag="c1196"
     CDS             complement(9153..9530)
                     /codon_start=1
                     /locus_tag="c1196"
                     /note="Escherichia coli O157:H7 ortholog: z4857"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79658.1"
                     /transl_table=11
                     /translation="MRNYRSYFMIRHEIERHLVQPQEMEIVLYLDPMLYWFNGHFAVQP
                     LLPGVAQLDWVMHYATTLLAPGWRFRSIQNVKFLAPLIPETTVTLQLTWQETSQVLTFC
                     YQRHDGDARHTASSGKIRLCR"
     gene            complement(9493..10851)
                     /locus_tag="c1197"
     CDS             complement(9493..10851)
                     /NRPS_PKS="Domain: AMP-binding (23-285). E-value: 2e-17.
                     Score: 54.7. Matches aSDomain:
                     nrpspksdomains_c1197_AMP-binding.1"
                     /codon_start=1
                     /function="putative enzyme; Fatty acid biosynthesis: Fatty
                     acid and phosphatidic acid biosynth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 46.1;
                     E-value: 4e-14)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="c1197"
                     /note="Escherichia coli O157:H7 ortholog: z4856"
                     /product="Putative enzyme"
                     /protein_id="AAN79659.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-10, bitscore:
                     30.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQTLSLSQWLTASRPVTTPVAWLGEYTWTLGHLRHDVALLIDHL
                     RDQPGNRWALCFENSYLFIVALLATLHSGKIPVIPGHNRAALLNVQRSLFDCVLSDKRL
                     GWNGPQFVVSTSHQMTTSTIAFDDIASDAFIELFTSGSTGQPKQIAKPLISLDQEANML
                     ATHFADRLLGCRFVASVMPQHLYGLTFRIFLPMALGLPLHAAMLWYSEQLAALSHTYRY
                     AFVSSPAFLKRLDLHLTPPPVEMILSAGGMLPWQDVEKTSTWLNIWPDEIYGSTETGIL
                     AWRYRQQDNIPWFTFSDVHLSQESEGVRVFSPLIPAEGLVLDDMLQFNENGQFHLIGRR
                     GRVVKIEEKRISLVEIEQRLLALDGIMDVAAIPLIRNGRQAIGVVVVPNKEARQIWQCS
                     GGKTLELSWRKALLPWLEPVAVPRYWRIIDEIPVNNMNKRVYAQLQELFHDTP"
     CDS_motif       complement(9781..9843)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_c1197_0002"
                     /evalue="1.70E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="c1197"
                     /protein_end="357"
                     /protein_start="336"
                     /score="11.3"
                     /tool="antismash"
                     /translation="IGRRGRVVKIEEKRISLVEIE"
     aSDomain        complement(9997..10782)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_c1197_AMP-binding.1"
                     /evalue="2.00E-17"
                     /label="c1197_AMP-binding.1"
                     /locus_tag="c1197"
                     /protein_end="285"
                     /protein_start="23"
                     /score="54.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LGEYTWTLGHLRHDVALLIDHLRDQPGNRWALCFENSYLFIVALL
                     ATLHSGKIPVIPGHNRAALLNVQRSLFDCVLSDKRLGWNGPQFVVSTSHQMTTSTIAFD
                     DIASDAFIELFTSGSTGQPKQIAKPLISLDQEANMLATHFADRLLGCRFVASVMPQHLY
                     GLTFRIFLPMALGLPLHAAMLWYSEQLAALSHTYRYAFVSSPAFLKRLDLHLTPPPVEM
                     ILSAGGMLPWQDVEKTSTWLNIWPDEIYGSTETGILAWRY"
     CDS_motif       complement(10402..10443)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_c1197_0001"
                     /evalue="1.70E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="c1197"
                     /protein_end="150"
                     /protein_start="136"
                     /score="14.5"
                     /tool="antismash"
                     /translation="LFTSGSTGQPKQIA"
     gene            complement(10848..11432)
                     /locus_tag="c1198"
     CDS             complement(10848..11432)
                     /codon_start=1
                     /locus_tag="c1198"
                     /note="Escherichia coli O157:H7 ortholog: z4855"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79660.1"
                     /transl_table=11
                     /translation="MMSGIRSLPMIKLLTGLLLLVWPFLIWLGLVHNSLHWLLPLMALL
                     LLLRLRQPRRQTGPLQVVTKIVAVVGIVLCVSSFLLKTYQLLLFYPVVVNAVMLAVFGG
                     SLRSTMPIVERLARLQEPDLPEKAVRYTRRVTQVWCLFFIFNGSIALFTTLYGNMPLWT
                     AWNGIIAYLLIGFLTAGEWLIRRKMIKRKTP"
     gene            complement(11434..11685)
                     /locus_tag="c1199"
     CDS             complement(11434..11685)
                     /NRPS_PKS="Domain: PP-binding (9-76). E-value: 2.1e-15.
                     Score: 48.9. Matches aSDomain:
                     nrpspksdomains_c1199_PP-binding.1"
                     /codon_start=1
                     /function="putative carrier; Fatty acid biosynthesis: Fatty
                     acid and phosphatidic acid biosynth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="c1199"
                     /note="Escherichia coli O157:H7 ortholog: z4854"
                     /product="Putative acyl carrier protein"
                     /protein_id="AAN79661.1"
                     /sec_met_domain="PP-binding (E-value: 7e-16, bitscore:
                     48.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDQQTIYQEVSALLVKLFEIDPQDIKPEARLYEDLELDSIDAVD
                     MIVHLQKKTGKKIKPEEFKAVRTVQDVVEAVERLLQEG"
     aSDomain        complement(11458..11658)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_c1199_PP-binding.1"
                     /evalue="2.10E-15"
                     /label="c1199_PP-binding.1"
                     /locus_tag="c1199"
                     /protein_end="76"
                     /protein_start="9"
                     /score="48.9"
                     /tool="antismash"
                     /translation="EVSALLVKLFEIDPQDIKPEARLYEDLELDSIDAVDMIVHLQKKT
                     GKKIKPEEFKAVRTVQDVVEAV"
     gene            complement(11697..11954)
                     /locus_tag="c1200"
     CDS             complement(11697..11954)
                     /NRPS_PKS="Domain: PP-binding (7-81). E-value: 2.5e-11.
                     Score: 35.9. Matches aSDomain:
                     nrpspksdomains_c1200_PP-binding.1"
                     /codon_start=1
                     /function="putative carrier; Fatty acid biosynthesis: Fatty
                     acid and phosphatidic acid biosynth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="c1200"
                     /note="Escherichia coli O157:H7 ortholog: z4853"
                     /product="Putative acyl carrier protein"
                     /protein_id="AAN79662.1"
                     /sec_met_domain="PP-binding (E-value: 8.5e-12, bitscore:
                     35.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQALYLEIKNLIISTLNLDDLTPDDIDINAPLFGDGLGLDSIDAL
                     ELGLAVKNEYGIVLSAESEEMRQHFFSVATLASFIAAQRA"
     aSDomain        complement(11712..11933)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_c1200_PP-binding.1"
                     /evalue="2.50E-11"
                     /label="c1200_PP-binding.1"
                     /locus_tag="c1200"
                     /protein_end="81"
                     /protein_start="7"
                     /score="35.9"
                     /tool="antismash"
                     /translation="IKNLIISTLNLDDLTPDDIDINAPLFGDGLGLDSIDALELGLAVK
                     NEYGIVLSAESEEMRQHFFSVATLASFIA"
     gene            complement(11929..12768)
                     /locus_tag="c1201"
     CDS             complement(11929..12768)
                     /codon_start=1
                     /function="putative"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141:acyltransferase (Score: 63.4; E-value: 3.1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="c1201"
                     /note="Escherichia coli O157:H7 ortholog: z4852"
                     /product="Putative phospholipid biosynthesis
                     acyltransferase"
                     /protein_id="AAN79663.1"
                     /transl_table=11
                     /translation="MALEPQMSKLMSRLGWAWRLVMTGLCFVLFGLGGLLLSVVWFNIL
                     LVLVWDTSRRRRLARRSIAASFRLFLTVAKGLGVLDYRIDGAEILRQERGCLVVANHPT
                     LIDYVLLASVMPETDCLVKSALLKNPFLGGVVRAADYLINSEAETLLPRCQQRLAQGDT
                     ILIFPEGTRTKPGEKMTLQRGAANIAVRCTSDLRIVTIGCSEHLLDKQSKWYDVPPARP
                     FFTVEVHGRVEINKFYDATSQEPTLAARQLNRHLLLQLQQGCLPLSGINNASALSGN"
     gene            complement(12747..13493)
                     /locus_tag="c1202"
     CDS             complement(12747..13493)
                     /codon_start=1
                     /locus_tag="c1202"
                     /note="Escherichia coli O157:H7 ortholog: z4851"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79664.1"
                     /transl_table=11
                     /translation="MVYRGRALMKFALNITNWQALAPGLSDVQQWQAWSRQPWAIDPAA
                     PLAKLSELPMMTARRLSSGSKLAVECGLTMLRRHQPDAVLYTSRHGELERNYRIVHALA
                     TEQALSPTDFALSVHNSSVGNLTIVAKQPIVSSSLSAGRDSFQQGLCEVLSLLQAGYQR
                     VLMVDFDGFLPEFYHPQLPAEMPTWPYAVALVIEAGDDWQCETQQAIAVNETTLPQSML
                     FLQHYLQNADAFSLPGERVQWRWSRR"
     gene            complement(13510..14568)
                     /locus_tag="c1203"
     CDS             complement(13510..14568)
                     /codon_start=1
                     /function="putative"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 121.6; E-value:
                     7.2e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="c1203"
                     /note="Escherichia coli O157:H7 ortholog: z4850"
                     /product="Putative O-methyltransferase"
                     /protein_id="AAN79665.1"
                     /transl_table=11
                     /translation="MYEQDTLSALDAITEAQRIAFAPMLFQAALCLRNAGILDYLDQQG
                     KQGAPLNAITEHTVLNEYAVGVLLDMGLSGRIITCKEGIYYLAKIGHYLLHDTMTRVNM
                     DFTQDVCYQGLFFLADSLNEGKPSGLKVFGDWPTIYPALSQLPDAARDSWFAFDHYYSD
                     GAFNAALPYVFANNPTTLYDVGGNTGKWALRCCKFNENIAVTLLDLPQQIVLAKENIAN
                     AGFSDRIDFHAVDMLSDAPLPGEADIWWMSQFLDCFSPEQIISILSKIASVMKPGAKLC
                     IMELFWDAQRFEATSFSLNASSLYFTCMANGNSRFYSAEKFYDYLNKAGFQVAERHNNL
                     GVGHTLLICQKK"
     gene            complement(14633..15022)
                     /locus_tag="c1204"
     CDS             complement(14633..15022)
                     /codon_start=1
                     /locus_tag="c1204"
                     /note="Escherichia coli O157:H7 ortholog: z4849"
                     /product="Conserved hypothetical protein"
                     /protein_id="AAN79666.1"
                     /transl_table=11
                     /translation="MKRYIKWFAITIFISMLSACVRTAPVQQISTTVSVGHTQEQVKNA
                     ILKAGAQRKWIMTQVSPGVIKARYQTRNHVAEVRITYTATYYNIKYDSSLNLQASDGKI
                     HKNYNRWVRNLDKDIQVNLSTGATL"
ORIGIN
        1 tcagggccag cgcttaatga tgatggatgt attaatgccg ccaaaggcaa agttgttact
       61 ctgcaaaaac tcacaatcaa cctttcgggc ttcatgcatg atgtaatcca gcgcgccaca
      121 gttcgggtct ggtttattca ggtttagcgt aggcgcaaac caaccttcgc gcatcatttg
      181 cagactcatc caggcttcga gcgcgccaca ggcaccaagc gtatgaccaa aataactttt
      241 cagcgaggag accggcacat tatcaccgta aatggttgct gtcgccagac tttctgccat
      301 atcaccgcga tcggtcgccg taccatgcgc tgaaatatag ccgatatctt gtgcacttaa
      361 cccggcgatt ttcagcgatt gctccataca atactgcatg gtttcgcgct gtggctgggt
      421 aatatgtgcc gcgtcgcagt tagtcgcaaa gccgacgatt tcaccgtaaa tggtcgcgcc
      481 gcgcgctttg gcgtgctcca gttcttcgag gatgagcgta cctgcgcctt caccaatcac
      541 cagcccgtcg cggttttcat cgaacggtga aggtgtggtt ttcggcgcat cattgtgctg
      601 gctggtggca aaaagcgtat caaataccgc tgcttctgaa gggcataact cttcggcacc
      661 accggcaacc atcaccgttt gataaccatg gcgaatggct tcccacgcgt agccgatagc
      721 ctgactacct gacgtgcagg cgctggaggt cggaatcacc cgcccgcgca gtccaaaaaa
      781 cagcccggtg ttaacggcag tagtgtgcgg catcatctgc acataggtgg tgccagtgat
      841 gttgttcgtg tgcttttccg tcagcatggt ggcgaactcg cttaccgggc cggtactgcc
      901 ggtcgatgag ccgtatgcaa tgcccgtttc gccgctggtt aatatcggat cgccaatcaa
      961 ccctgcctgc tctaacgcca gctcgctggc acgggtcgac atttgcgaca cgcggcccat
     1021 cgcacggata cgcttgcggg tgtagtgctc cggcagcgtg aaatcatcaa caggcgcgcc
     1081 aagcagggtg tgcaggccgt cgtaaacctg ccactccggc attttgcgca ccgcattttc
     1141 atacgccagt aagcgtgcag aaacgtcctg ccagttttca ccaaaggcag tcacgccgcc
     1201 cattcctgta atcactacgc gacgtgtcat aacatccctc cattgatgga aataacctgg
     1261 cgggtgacgt aacccgcaat atcagacatt aaatagctgg caagcccggc aacttcttcc
     1321 gcctggccca tgcgtttcat ggggatcatc gacattgcct ctttcagagc gctctcttcc
     1381 atttcgatca tcccggtatc aataagccct ggcgcgatgc aattgacggt gattttgcgc
     1441 ttcgcgagtt cgatagccag tgcttttgtt gcgccgataa ttccggcttt ggcagcgctg
     1501 tagttcacct ggccgcgatt gcccattacg ccggaaaccg aggacagcgt gatgatgcgc
     1561 ccaccctggc gtgcgccgat catcggcata atgcacggct gaatgacgtt gtagaaactg
     1621 tcgaggttgg tgtggatcac cgcatcccag tcgtcattgc ttaaagccgg aaaagcggca
     1681 tcgcgggcga tcccggcgtt actgaccacg ccgtaccagg caccatgttg cgcgatctcg
     1741 tgctccagca cttcccgaca ctgttcgcgg tttgcgacgt cgaaactgag caaacgcccg
     1801 ttacccccgt tggcgacaat ggcgttcagc gtttcctgag cgcccgcggc gtcacggtga
     1861 tagtgaacgc caatgttaaa gccgtctgcc gccagttggc aggcgatggc gcgaccaatg
     1921 cctttgctgg caccggtaac cagaactgaa cgactcatca ggacgctcct tgttgaaaca
     1981 gggtggtaag ttcttccgcg gtcggctgga aggtgttaat gcggcccgtc gcctcgccgt
     2041 cgttgatgct gcactcaaaa ctgccgaagc gatcgtcctg catcagcagc ttgacggtaa
     2101 tagtcagcgt ctggcctgcg ggcagaatgc cagcggtgca aagcaattca cgcgcgccca
     2161 gtatcatccc taactcaata ctgtttttgc cctgctggtg gcgatgccag ccagaccaga
     2221 cgccgacggt ttgcgccatc agttcaaggg caaaccagcc agggagattg ccgtccgggt
     2281 cgagaaacgg tgccagtacg ccactgggcg aaaccgtcac gcggcacacc gcgctgtcat
     2341 cgctgacgct caccacgtct tccagcagta acatgggcgc gtcgtggggc agataagcgc
     2401 cgggggataa atagtggctc acgaaaccct cccgagcaga atgctggcgt tattgccgcc
     2461 aaaggcgaag gaattggaca ggatcaccgg acgtgccagc ggctgcggtt tttcgataat
     2521 gccacacggt ggcagcgtgg gatcgcgcgg cgacagactg aagtcctgag cgggcagcgg
     2581 taaatcacgc tgtaaaatca acatactaat tgctgcctcg gtaatgcccg ctgcgcccag
     2641 cgtgtgtccg gtcaaatgtt tggtggagct gcacggtacg cgttcgccaa acagggcgtt
     2701 aaccaccatt gattcaatct ggtcgttgag ctgtgtggcg gtgccgtgca ggttgatata
     2761 gccgacgtca tccggcgtaa gctgcgcatc ggtcagcgcc tgattaatag cgcggatcgc
     2821 tccttcgccc tgcggatgcg gggctgaaat atggtaagcg tcgctcgatt caccaacgcc
     2881 cagcaacgcg atgggctgcg gttcccgggt cagcagcatt agccccgccc cttcaccaat
     2941 ggtgatacct gcgcggtcac gaccaaacgg ctgacataag gttggcgaca gcgattcgag
     3001 gctgtgaaaa ccgttaatcg gcatccggct cagggtgtct gcgccaccca caatggcggc
     3061 atcgaccagc cccgcttcga taagcctgcg cccgctgatt atcgctctgg cgctggaaga
     3121 gcaggcggtt gaaagggtat aggccgggcc gtcgagcgcc agccagtggc tgagaaaacg
     3181 cgacggatcg ccgagttcct gttgcgcgta gtgccatgtg gtgctcggct gcccgtgggt
     3241 gcgcaggtta acgtgcgtgt cgccttcatg caggccggag gtgctggtgc caagtacaat
     3301 cgcgatgcgc tcgcgaccat atttcgctat agcgtcatca acctgcggct ggagctgcgc
     3361 cagcgccgcc agcaggatct gattgttgcg cgagcggtgc gcagcgaatt tttccgggat
     3421 aagcggaagc tcgccatcca cgccagccag gaccgcctgc ggatgcccct gcaaccagcc
     3481 tgcgcgcggg cgcattccgg gagcaacacc gcgagtcagg ttggttgcga tttcgtcaag
     3541 gttatttccc agggcgttga tcatgccgac ggcggaaata taaatcatat cagtcaccta
     3601 agtattgaat ggtgatgtgg tatttaaaga catgctgctc aatgctgatt ggcacgcgtt
     3661 ttccctggcg attcagatag gtgatttccg tgaccagttt gccgctggcg ttacgcagct
     3721 cgcgtttgtc gccgttgtcg cgaagcgtcc agcctgtggg aagttgcggt tgccaggcgc
     3781 taatcggcca gtggctgagc atcacgtcag ccagtacctg acttgcgggc ggtaactgtg
     3841 ggacgacgat ggattgctcg gcgcgtagcc cttttgcatc gtaggtcacc agaaacaggc
     3901 gaatgccgac cgacgacagc ccggcaaggg tgattttctg atcttcggca ttaagcatca
     3961 ctagcagaga ctgggttttg ccgttgaagc tgccggtcaa cagttgctgg gaattgactg
     4021 cgggtgaaat ccccggcgca ggcagcgtga tgagcgtacc aggttgcagc cacgcctgcg
     4081 ggcggccttc ctgttccggt tgcgagtggc tacagccagt gaggataagc gtagcggtca
     4141 gggcgagcgc tcgccagaat gtggatttga tcattttttt gttctctttt tatcgggcat
     4201 cgccagcggc gaaagcagga aggcggtgaa aataccgctc accagcacaa tgccaaaact
     4261 gctgatggcc tgggtggcgc tgaataccag cattcccagc gtcagcaagg tggtgagcat
     4321 tgccagcgtg atcgccagta gggaagttaa cggtgtaccg cgcggattac tgaaaaacag
     4381 cgtgtaattg atgccgatgc caagcaccag caccagcgcc agcagcgaaa agagattcac
     4441 cgcctgcccg ctaatcgcca gcacagccag accgcagccc agcgaaagca ccgaaggcac
     4501 caggctgata aaccctttgc gccagccgag gcgggccact gcgccgcagg caattactgc
     4561 cagcgccacc agcaacaagc cggttaacac ataacggtaa agtgcgaaca attcatcaaa
     4621 ggtgtttttg cgatcaaccc aggcaatgcc acaagggtaa tagctggaga tttcctgtag
     4681 cgccgcgcta tttttaaccc cttcaaccgg caccagcacg ccgcttgcgc cattttccag
     4741 cgtcagccac agcagacgcc agccttcact ggcggggctt gccagccatt catcaacctt
     4801 caccggcatg gcgttgagat ccgggttcac tgttgtcagc ccggcatttt gcagtgcttt
     4861 tgttactgtc ggggccgctg ttgtcagcag atgtaaatct tcctcctgcc gcgcaaggga
     4921 gttcagtgga atggtgcggt atttgctgat aagcccgtct tttttcgcct tctccagcga
     4981 ggtggtaaat ttctccagtc gccgtaatgt ttgctgtggg gagtcgccgt aaaccacgaa
     5041 ccatttttga tcgacgctct gcccggtcag ggcggtaatg gctttctcct gcgccagaat
     5101 atgctgcggc agcgcctgta actgcgagat atcgtcatcg acgcgtagca ttgacatccc
     5161 cgccagcgaa aacagcgcca gcgcgacgga cagaccccgc gacagttttt tattgcgccg
     5221 ccacgctgcc agccagcgta gcatcagcgc catcgccgga accggacgca ccggcaggcc
     5281 acggcacagc cacggatgcc agaacaggac ggtcagacag gaggcgctca acccgatggc
     5341 ggcaaaaatc gccatctggc ggataccggg gaagggggcg agcatcataa tcagatatgc
     5401 cgccacggtg gtgagcagcg ccagcagcag ggcattgcgt actttcgcca ggctttgcca
     5461 cggcgaaacg tcgttgccgt gcaccatccg ctcggtgaga taatagagcg tgtagtcagc
     5521 ggaaatgccg ataacgctca tgctcatcac cagcgtcatc aggtgtaatt caccgaaaat
     5581 caataaagtg gcgaccgttc ccgccagcgc gccgatgccg atggaaatca cgcaaagcaa
     5641 caatgggcgc aaagagcgga acaccgccac aatcagtaat atcaccccca gcagcgttgc
     5701 cacgcccagg gttgagatat cctgcttcgc ctgttgactg gcgtaatcgc tgtaaaatac
     5761 cgtgccgcgc gagagcaact gcgcctgtgg gtaacgcgtt ttcagatcct tttccagcgt
     5821 attcagggtc gtgatgagct ggtgggtttg ctgcatatca aacgacgatc ccgccagttc
     5881 accgtgcagc agataccagt agttgccctg gggatcctgc gtcaccagcc agccgtccat
     5941 cagccgcaaa cgctggccgt ttttcgccat cgccagctgc gagccgcgca ttaacatcag
     6001 cggatcgttt tgcagctcct tgccgcttac cccggagaat gcggaataaa gctgggagag
     6061 gatccactgc gcctgcgctt cgccgccgtt ttgcaggcgg gcgcgggtgt cggggtcaat
     6121 caggccgttg cggtgctgcc agaaaaacgc tccccacgat tgctggctgg cggcatccat
     6181 tggtccttta acgtcgccga gcgcagcgga tttttgcagc agcgtcagcc actcctgagc
     6241 gaccctggga ttagcctctt taccggggct gaccagccac accagttggc ggtccagacg
     6301 ctgcataaag ccgtcattca gcgctggggg aatatcgccc atcacctgtt tgggtaacat
     6361 agccagcacg ctactgttca gccgtgattg cggcagcagg atcagcaacg ccgccgccat
     6421 gaccaggcag actagccccc ataacagcgc ggggcgttta ctgggcggca aaacgttggt
     6481 gttcgtcatc ggtcagttgc gctggcgtca gttgatgttg ggtaagagca atatcggtgc
     6541 gatcgccctg tttatcatta agttgaatgc tctccagata ggttttcccg gcgagatcga
     6601 tggtgttgaa aattttatcc agcggcgtgg tggtcggcgt caggcgcagc gtccagcggc
     6661 cttcgccttt gtcagcaaat tcgacgcgga agttttgttc cagcactttg cgatcggcct
     6721 ggaacagcgc gcgcagcagg tggttaaact ggaacatctg cgggttgttt tctgccgtga
     6781 tgatttgcgg cggctgaccg ttgatcacct gcaccatgcg tttatcatcc agcaatagct
     6841 gcatggggaa cggtgaggtt tgatcccaca ataacccctg gtcgcgggcg atcaacatct
     6901 gaccctgaga tcgcagcggc tgcggcagat ctttaatcgt ccgggtttga tcaaaatggg
     6961 cgcggatcac cggttgttcg gtaaagcgtt gctgaagatc gtccagggtc agggcgctca
     7021 caaacgggct aatcagcagc gccagcagcg gtaaaaattt catggtttga ctcccatgcg
     7081 ttcaaacaga atatcggggc tgacaaagca cagttcgcga ctttgctcgt cgaccgcgac
     7141 ctgaatggtg tatccggtgg tggcgcgttt gcccgtttcg gcatcgaaaa tctgatagcc
     7201 aatccgcaga cggttttcga actcttcgat atgcgcacgc acgcggatgc gttgctcaaa
     7261 ggtgagggcg tggcgatatt tcacccgcgc atcgaccact ggccacaaat aaccggactc
     7321 tttcatctgc cgatagccgt aattgaactg gttgagcagc gcctcgcggg ccacttcaaa
     7381 gtagcgaaaa tagttaccgt gccaggccac gcccatcata tcgacgtcgt gaaagggaat
     7441 ggtcagctcg acttcagcgg taaatcgggg atcgttaagc accctttact ccttgtcctg
     7501 aatttccggc agttgccaga aatcgaaaaa attaaaccag tcgaggggcg actggagcgc
     7561 gtaatgttcc agacgcgcgg cgtagtggtc gatagcgttt tgcagcgcct gttggcgttc
     7621 gccacgcggc aacagcagcg ggtcggcaaa ggtttcgcag tgaatatgca gcttgccgtg
     7681 ctggcgtagg gcgaaaatca gattcaccgg gcagcgcaaa atagacgcga gaataaacgg
     7741 cccctgtggg aaaggcgcag gctggcccat aaacggactc cagcagacgc gccagtcgcc
     7801 gccgcgttgc gggttgacgg cgatgcggtc accgacaatc gccacccatt cgccgttatc
     7861 cagcttctct ttcagcagga tggcggtttc cgggccgata tctgttaccg gcatcaggtt
     7921 aatgcctgcc tgaggagcca tctcctgcat tatctgttta aagcgttggg cgttttcgct
     7981 aaacaccagc gcgttaatgg ttttgtagcc ctgaattttt gccagcgccc ggcacacttc
     8041 cacatcgcca agatgcgagg ccagcagcaa tttgccgcgc ggatcgcgga cgtcaagcgc
     8101 cgcttctgcg cctggcgcaa acagcacatc acgccccagt tgtagctcgc cgcgccagct
     8161 ggcgattttg tcgagcatgg cattaccgaa acgtagaaag tgctgatagc tgttgatttt
     8221 tgctgcctgt ggttgttgtt ggcgcacacg ggcgagccag tcttgcgacg ctttacgcgc
     8281 acgagcagcg gtgagccagt agacgcccac caccgggtaa agcagcgcgg taaacgccgt
     8341 tcttcccagc agacgccaga ccagcagcat caggcgcatt ccccataacc ctttaacttc
     8401 actctgccgc gcccagtggc tggaagagtg gcacatcagc agtgaaggaa tacgcggcaa
     8461 catgccgaaa aacagacgcg tgtgcatgag cgagatgcgg acgttatctt tcagggcatc
     8521 aaaatgcgaa agcccgtcca gcggataggt gacgcgggtc ggcacgaaat agctggtatt
     8581 tccctgccag tagaggcgca ccatcacttc ggtgtcgaaa tccatccgct tgccgatggt
     8641 ggcgcgtttt gccagttgca gcgtcggcgc aaccggataa acgcgaaaac cgcacatgct
     8701 gtctttcagt tgcagggaga gcgtttcgat ccatacccag acgtgggtga tccagcgccc
     8761 gtacagccgt gagcggggaa tggagtcatc gtaaattggc tgaccggaga tcagcgccgc
     8821 agggtgttgt tcagcgagtg ccagcagttt ggggatatct tcaatcgcat gttgaccgtc
     8881 agcatccact tgcaccgcat ggctgaaccc tgcgtctgcc gctgcctgca agccacgcat
     8941 caccgctgcg cctttacctg cgttttctgc caggcgaatt aaggtcacgc caggctgttc
     9001 gctaaccaga ttatccagtt gctgttgcgt ggcggcatcg ctgccgtcat ccaccacaat
     9061 acagggcaga ttaaatggct taagacgcgc cagcacgccc ggcatcatcg cgccgtggtt
     9121 gtagcagggg atcaacacgc agggagaaaa gtttaccgac ataggcggat cttcccgcta
     9181 ctggcggtgt ggcgggcgtc accgtcgtga cgctgatagc agaaagtgag tacctgactt
     9241 gtttcctgcc atgttaattg cagggtaaca gtcgtctcag gtataagtgg cgccagaaat
     9301 ttaacattct ggatactacg aaaacgccag cccggagcaa gcagcgtggt agcataatgc
     9361 attacccagt ccaactgggc cacgcctggt aacagaggct gtacggcaaa atgaccatta
     9421 aaccagtaga gcatcgggtc aaggtataga acgatttcca tctcctgcgg ttgaaccaga
     9481 tggcgctcaa tttcatggcg tatcatgaaa taactcctgt aattgcgcat agacacgctt
     9541 attcatattg tttactggta tttcatcaat aatgcgccag taacgaggta ctgcaacagg
     9601 ttcaagccat ggtaatagtg ctttgcgcca ggacaactcc agagttttcc ctccggagca
     9661 ttgccatatt tgacgggcct ctttatttgg tacaaccacg acaccgatag cctggcgacc
     9721 attgcgtatt aatggtattg cagcgacatc cataataccg tcaagtgcca gaagtcgttg
     9781 ttcgatttca accagtgata tccgcttctc ctctattttt accactcgac cacgtcgtcc
     9841 gatcaggtgg aactgaccgt tttcattgaa ttgcaacata tcgtcaagca ccaatccttc
     9901 agcagggatt agtggcgaaa agacacgaac cccctcactt tcctgtgaaa gatgaacatc
     9961 agaaaaagta aaccagggga tattatcctg ttgacggtaa cgccatgcga gaatacctgt
    10021 ttcggtacta ccatagattt catcgggcca tatattcagc caggtggaag ttttctctac
    10081 atcctgccat ggtagcatac cgccggcaga gagaatcatt tccactgggg gaggcgtcag
    10141 atgaaggtcg agtcgcttaa ggaacgccgg gctgctgaca aaggcatagc ggtaggtatg
    10201 gcttaatgcg gcaagttgct cagaatacca gagcattgcg gcatgcaatg gcaggccaag
    10261 tgccatgggt aaaaaaatac ggaaagtcag cccatacagg tgctgaggca tcacggatgc
    10321 tacaaaacga cagcccagta gtcggtctgc aaagtgagtt gccagcatgt ttgcttcttg
    10381 atcaaggctg ataagaggtt ttgcaatttg ttttggttgt ccggttgaac ccgatgtgaa
    10441 aagttcaata aacgcgtcag aagcaatatc atcaaaggct atcgtgctgg tcgtcatctg
    10501 gtgagatgtg cttacaacaa actgtggacc gttccagccc agccttttat cactcaggac
    10561 gcaatcaaac aaggagcgtt gtacatttaa caaagcggcg cgattatggc ccgggattac
    10621 cgggatttta cctgagtgta gcgtggccaa caacgctaca ataaaaagat agctgttttc
    10681 aaaacaaagt gcccagcgat tgcctggctg gtcgcgtaaa tggtcgatca aaagcgctac
    10741 atcatgccgc agatgcccca gtgtccaggt atattcccca agccaggcaa caggagttgt
    10801 tacagggcga gaggctgtca accactgtga aagagagaga gtctgattca tggtgttttc
    10861 cgtttgatca tcttacgacg tatcagccat tcccctgcag tcaggaaacc tatcagaagg
    10921 taagcaatga taccgttcca ggctgtccac aagggcatgt tgccatacaa ggtggtaaat
    10981 aacgcaatac tgccattgaa aataaaaaac aggcaccaga cctgcgttac gcggcgggta
    11041 tatcgcacgg ccttttccgg gaggtctggc tcctgcaaac gtgccagccg ctcaactatc
    11101 ggcattgtcg accgcagcga accgccaaaa accgccagca tgactgcgtt aaccactacc
    11161 gggtaaaaca gcagtaactg gtacgttttc aacagaaaac tggagacaca caatacaatg
    11221 cccacaacag caacgatttt tgtgacgacc tggagcggcc ccgtctggcg acggggctgg
    11281 cgcaggcgca ataaaagcaa cagcgccatc agcggcaaca gccagtgcag gctgttatgc
    11341 accaaaccta gccagattaa aaaaggccag acgagcagca ataatccggt cagcaactta
    11401 atcatcggta gcgagcgaat gcccgacatc aaattagcct tcttgtagca ggcgttctac
    11461 agcctcgaca acatcctgga ctgtacgcac tgctttaaac tcttccggct tgattttctt
    11521 accggttttc ttttgcaggt gcacaatcat gtcaacggcg tcgatgctgt ccagttccag
    11581 atcttcgtac agtcgcgctt caggtttgat gtcctgcgga tcgatttcaa acagcttaac
    11641 cagcagggct gagacttcct gataaatggt ttgttggtct gtcatgatgg ttttcctcag
    11701 gcacgttgcg cagcaatgaa agaggccaga gtggcgacgg agaaaaagtg ctgacgcatt
    11761 tcttcgcttt ccgcagagag cacgatgccg tactcatttt ttactgccag tcccagttcc
    11821 agtgcatcga tagagtccag ccctaaaccg tcgccaaaca gtggcgcatt gatatcaata
    11881 tcatcaggag tcaagtcgtc cagattgagg gtgctgatga tgaggttttt aatttccaga
    11941 taaagcgctt gcattattta ttcctgatag aggtaaacaa ccttgctgta attgaagcaa
    12001 aagatgccgg tttaactgtc ttgcagccag cgtcggctct tgtgaagttg catcgtaaaa
    12061 tttattgatt tctacccgcc catggacttc aaccgtaaaa aacggcctgg caggcgggac
    12121 gtcataccac ttactttgtt tatccagcag atgctcgcta cagccgatcg tcacgatgcg
    12181 taaatcgctg gtgcagcgca cggcaatatt cgctgcaccg cgctgtaacg tcattttttc
    12241 accgggcttc gttcgtgtgc cttcggggaa aatcaggata gtgtcaccct gtgccagtcg
    12301 ctgttggcag cggggtaaca gggtttctgc ttcgctgttg attaaataat ctgccgctcg
    12361 cacgacgccg ccaagaaaag gattttttaa cagcgcgctt ttcaccaggc agtcagtttc
    12421 tggcatgact gatgccagca gcacgtaatc gatcagcgtg ggatgattgg ctacgacgag
    12481 gcaaccgcgt tcctgacgta aaatttcagc gccatcaata cgataatcca gcacgccaag
    12541 ccctttcgcg acagttaaaa acaggcgaaa actggcggca atgctgcgac gtgccaaacg
    12601 acggcggcgg gaagtatccc acactaaaac taacaatatg ttaaaccaca cgactgaaag
    12661 cagcaggccg ccgagaccaa acaggacaaa acataacccg gtcatgacca gtcgccatgc
    12721 ccatcccagg cgcgacatca gcttactcat ctgcggctcc agcgccattg cacgcgctcg
    12781 ccaggcagtg aaaaagcatc tgcattttgt aaatagtgct gtaaaaacaa catgctttgc
    12841 ggcagtgttg tttcatttac cgcaatggct tgctgcgttt cacattgcca gtcatcgcca
    12901 gcttcaatca ccagcgcgac ggcgtacggc caggtaggca tttctgcggg cagttgcggg
    12961 tgataaaact caggtagaaa gccatcaaaa tcgaccatca acacgcgctg gtatcccgct
    13021 tgtagcaggc taagcacttc acacaaacct tgctggaaac tgtcgcgacc agccgaaagc
    13081 gatgacgaaa cgatcggctg tttggccaca atggtcaggt tacccacgga agagttgtgt
    13141 acggaaagcg cgaagtccgt cggagaaagc gcctgttcgg ttgccagtgc atgaacaatg
    13201 cggtaattgc gctccagttc gccatgacga ctggtataca aaacagcgtc tggctgatgg
    13261 cggcgtagca ttgtcagacc gcattcaaca gccagtttgc tgcctgaact gagacgacga
    13321 gcggtcatca ttggcagttc acttaatttt gccaacggcg cggcagggtc aatcgcccac
    13381 ggctggcgcg accatgcttg ccattgctgc acatcgctaa gtccaggcgc cagtgcctgc
    13441 cagttggtaa tatttaatgc aaatttcatc aacgcgcgcc cgcggtaaac caaaattatt
    13501 aagtgacgat tatttctttt ggcatatcaa aagtgtatgc ccaacgccta aattattgtg
    13561 acgctctgct acctggaatc ctgctttatt cagatagtcg taaaatttct ctgcactata
    13621 gaaacggctg ttaccgtttg ccatgcaggt aaaataaagt gaggatgcat tcaggctaaa
    13681 cgatgtcgct tcaaaccgct gtgcatccca gaacaactcc atgatgcaaa gttttgcgcc
    13741 aggcttcatt acgctggcaa ttttgctgag tatgctaatt atttgttcgg gtgaaaaaca
    13801 gtctaaaaat tggctcatcc accagatatc agcctcgcct ggtaatggtg catcgcttag
    13861 catatccacc gcatggaaat ctatgcgatc agaaaaacct gcattcgcga tattttcttt
    13921 cgccagtacg atttgttgtg gcagatctaa taacgtaacg gcgatgtttt cattgaattt
    13981 gcagcagcgc aaagcccact tacccgtatt gccacccaca tcgtacaagg ttgtggggtt
    14041 gttggcgaat acataaggca gtgcggcgtt aaatgcgcca tctgaatagt aatgatcaaa
    14101 cgcaaaccag ctatcacgtg cggcgtctgg taattgcgaa agtgccggat atatcgtcgg
    14161 ccagtcgcca aatactttta acccggaagg ttttccttca ttgagtgaat cggcaaggaa
    14221 gaagagcccc tggtaacaga catcctgggt gaaatccata ttcacgcgag tcatagtgtc
    14281 atgcaggagg taatgaccga ttttcgccag gtaataaatt ccctctttac aggtaataat
    14341 tcgcccgctt aagcccatat ccagtaacac acccacggca tattcattca ggactgtgtg
    14401 ctcagtaatc gcattaaggg gagctccctg tttaccctgt tgatccaaat aatctaatat
    14461 tcctgcattg cgcaggcaca aagctgcctg gaaaagcata ggagcaaagg caatccgctg
    14521 tgcttcggtg atggcatcca gtgcgctgag cgtgtcctgt tcgtacatat ataaccattc
    14581 ttatagagaa agttaaatac tatcgggcca ttccagcccg atatcagcat cactataacg
    14641 ttgctcctgt agataagtta acctgtatat ctttatccag gttacgcacc cagcggttat
    14701 agtttttatg aatttttcca tcagaagcct gcagattcag gctactgtca tatttgatgt
    14761 tatagtaggt agctgtatat gtaatacgaa cctctgcaac gtgatttcgt gtttgatagc
    14821 gagctttaat aactccaggg gacacttgcg tcataatcca cttgcgctgc gcacctgctt
    14881 tcaaaatggc atttttaacc tgctcctgag tatgacccac actgacagtg gtgcttatct
    14941 gttgcactgg ggccgtacgg acacaggcac tcaacatact gataaaaatt gtgatggcaa
    15001 accattttat ataacgtttc at
//
