BGC0000841: alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 1,152,119 - 1,163,141 nt. (total: 11,023 nt).
This entry is originally from NCBI GenBank CM000914.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
Operons
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000841
Short description alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (non-nrp beta-lactam)
Loci
CM000914.1
1152119 - 1163141
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • alanylclavam
  • 2-hydroxymethylclavam
  • 2-formyloxymethylclavam
  • clavam-2-carboxylate
  • clavulanic acid
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
alanylclavam Evidence:
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C8H12N2O4
Chemical database entries
PubCHEM
2-hydroxymethylclavam Evidence:
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C6H9N1O3
Chemical database entries
PubCHEM
2-formyloxymethylclavam Evidence:
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C7H9N1O4
Chemical database entries
PubCHEM
clavam-2-carboxylate Evidence:
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C6H7N1O4
Chemical database entries
PubCHEM
clavulanic acid Evidence:
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C8H9N1O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_p1074
  • EFG04560.1
  • ceaS1
 1152119 - 1153762 (+) Carboxyethyl arginine synthase isoenzyme 1
  • Precursor biosynthesis
  • Knock-out
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  • SCLAV_p1075
  • EFG04561.1
  • bls1
 1153786 - 1155369 (+) Beta-lactam synthetase isoenzyme 1
  • Precursor biosynthesis
  • Knock-out
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  • SCLAV_p1076
  • EFG04562.1
  • pah1
 1155366 - 1156739 (+) Proclavaminate amidinohydrolase
  • Precursor biosynthesis
  • Knock-out
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  • SCLAV_p1077
  • EFG04563.1
  • oat1
 1156931 - 1158289 (-) Probable glutamate N-acetyltransferase 1
  • Precursor biosynthesis
  • Knock-out
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  • SCLAV_p1078
  • EFG04564.1
  • cvm6P
 1158740 - 1160263 (-) Putative pyridoxal phosphate-dependent aminotransferase
  • Scaffold biosynthesis
  • Knock-out
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  • SCLAV_p1079
  • EFG04565.1
  • cvm7P
 1160394 - 1163141 (-) Putative transcriptional regulator
  • Scaffold biosynthesis
  • Knock-out
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Biosynthesis information
Operons
Genes Evidence
ceaS1, cvm7P, bls1, cvm6P, oat1, pah1
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Cleaned up synonym list
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Updated bioactivity data
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2019-10-16
Updated compound(s) information (NPAtlas curation)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: FHMX74FQXDJKCZZPHECQNTZR)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Similar known gene clusters from MIBiG 4.0
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