BGC0000841: alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,143,786 - 1,165,369 nt. (total: 21,584 nt).
This entry is originally from NCBI GenBank CM000914.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
Operons
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000841
Short description alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (non-nrp beta-lactam)
Loci
CM000914.1
1152119 - 1163141
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • alanylclavam
  • 2-hydroxymethylclavam
  • 2-formyloxymethylclavam
  • clavam-2-carboxylate
  • clavulanic acid
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
alanylclavam Evidence:
Copy SMILES
C8H12N2O4
Chemical database entries
PubCHEM
2-hydroxymethylclavam Evidence:
Copy SMILES
C6H9N1O3
Chemical database entries
PubCHEM
2-formyloxymethylclavam Evidence:
Copy SMILES
C7H9N1O4
Chemical database entries
PubCHEM
clavam-2-carboxylate Evidence:
Copy SMILES
C6H7N1O4
Chemical database entries
PubCHEM
clavulanic acid Evidence:
Copy SMILES
C8H9N1O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_p1073
  • EFG04559.1
 1151887 - 1152120 (-) Hypothetical protein
    copy AA seq
    copy Nt seq
    • SCLAV_p1074
    • EFG04560.1
    • ceaS1
    		 1152119 - 1153762 (+) Carboxyethyl arginine synthase isoenzyme 1
    • Precursor biosynthesis
    • Knock-out
    copy AA seq
    copy Nt seq
    • SCLAV_p1075
    • EFG04561.1
    • bls1
    		 1153786 - 1155369 (+) Beta-lactam synthetase isoenzyme 1
    • Precursor biosynthesis
    • Knock-out
    copy AA seq
    copy Nt seq
    • SCLAV_p1076
    • EFG04562.1
    • pah1
    		 1155366 - 1156739 (+) Proclavaminate amidinohydrolase
    • Precursor biosynthesis
    • Knock-out
    copy AA seq
    copy Nt seq
    • SCLAV_p1077
    • EFG04563.1
    • oat1
    		 1156931 - 1158289 (-) Probable glutamate N-acetyltransferase 1
    • Precursor biosynthesis
    • Knock-out
    copy AA seq
    copy Nt seq
    • SCLAV_p1078
    • EFG04564.1
    • cvm6P
    		 1158740 - 1160263 (-) Putative pyridoxal phosphate-dependent aminotransferase
    • Scaffold biosynthesis
    • Knock-out
    copy AA seq
    copy Nt seq
    • SCLAV_p1079
    • EFG04565.1
    • cvm7P
    		 1160394 - 1163141 (-) Putative transcriptional regulator
    • Scaffold biosynthesis
    • Knock-out
    copy AA seq
    copy Nt seq
    Biosynthesis information

    No biosynthesis information available for this record.

    Operons
    Genes Evidence
    ceaS1, cvm7P, bls1, cvm6P, oat1, pah1
    Annotation changelog

    Entry version: 4

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Cleaned up synonym list
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Updated bioactivity data
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2019-10-16
    Updated compound(s) information (NPAtlas curation)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2015-06-12
    Submitted
    • (ID: FHMX74FQXDJKCZZPHECQNTZR)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Similar known clusters from MIBiG 4.0
    Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
    Detailed help and explanations are available here.

    Click on reference genes to show details of similarities to genes within the current region.
    Double click on a reference drawing to reverse the display of the genes.

    Click on an accession to open that entry in the MIBiG database.


    Location:

    Identifier
    Identity
    Coverage