BGC0000841

BGC0000841: alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064

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Location: 1,152,119 - 1,163,141 nt. (total: 11,023 nt).
This entry is originally from NCBI GenBank CM000914.1.

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General

Compounds

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History

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000841
Short description	alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status	Minimal annotation: no A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: complete Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	Other (Non-NRP beta-lactam)
Loci	NCBI GenBank: CM000914.1
Compounds	alanylclavam 2-hydroxymethylclavam 2-formyloxymethylclavam clavam-2-carboxylate clavulanic acid
Species	Streptomyces clavuligerus ATCC 27064 [taxonomy]
References	Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus. Jensen SE et al., Antimicrob Agents Chemother (2000) PMID:10681345 The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. Tahlan K et al., J Bacteriol (2004) PMID:15342599 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus. Tahlan K et al., Chem Biol (2007) PMID:17317567 Carboxyethylarginine synthase genes show complex cross-regulation in Streptomyces clavuligerus. Kwong T et al., Appl Environ Microbiol (2013) PMID:23104404 Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus. Tahlan K et al., Antimicrob Agents Chemother (2004) PMID:14982786 5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus. Kwong T et al., Antimicrob Agents Chemother (2012) PMID:22751548 Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene. Jensen SE et al., Antimicrob Agents Chemother (2004) PMID:14742203 Alanylclavam biosynthetic genes are clustered together with one group of clavulanic acid biosynthetic genes in Streptomyces clavuligerus. Zelyas NJ et al., J Bacteriol (2008) PMID:18931110

Chemical products information

alanylclavam

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C₈H₁₂N₂O₄

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PubCHEM

2-hydroxymethylclavam

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C₆H₉N₁O₃

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PubCHEM

2-formyloxymethylclavam

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C₇H₉N₁O₄

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PubCHEM

clavam-2-carboxylate

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C₆H₇N₁O₄

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PubCHEM

clavulanic acid [synonyms: clavulanate]

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C₈H₉N₁O₅

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NPAtlas
PubCHEM

List of genes involved in compound(s) production

Identifiers	Position	Product	Functions	Evidence	Extra
SCLAV_p1074 EFG04560.1 ceaS1	1152119 - 1153762 (+)	Carboxyethyl arginine synthase isoenzyme 1	Precursor biosynthesis	Knock-out	copy AA seq copy Nt seq
SCLAV_p1075 EFG04561.1 bls1	1153786 - 1155369 (+)	Beta-lactam synthetase isoenzyme 1	Precursor biosynthesis	Knock-out	copy AA seq copy Nt seq
SCLAV_p1076 EFG04562.1 pah1	1155366 - 1156739 (+)	Proclavaminate amidinohydrolase	Precursor biosynthesis	Knock-out	copy AA seq copy Nt seq
SCLAV_p1077 EFG04563.1 oat1	1156931 - 1158289 (-)	Probable glutamate N-acetyltransferase 1	Precursor biosynthesis	Knock-out	copy AA seq copy Nt seq
SCLAV_p1078 EFG04564.1 cvm6P	1158740 - 1160263 (-)	Putative pyridoxal phosphate-dependent aminotransferase	Scaffold biosynthesis	Knock-out	copy AA seq copy Nt seq
SCLAV_p1079 EFG04565.1 cvm7P	1160394 - 1163141 (-)	Putative transcriptional regulator	Scaffold biosynthesis	Knock-out	copy AA seq copy Nt seq

Annotation changelog

MIBiG version	Submitter	Notes
1.0	Hidden contributor (ID: FHMX74FQXDJKCZZPHECQNTZR, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4 Updated compound(s) information (NPAtlas curation)
3.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Cleaned up synonym list Updated bioactivity data
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

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