Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000841.1:
Cluster 1Other111023

BGC0000841, alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: alanylclavam
PubChem ID: 194618
SMILES string: Copy to clipboard
Molecular formula: C8H12N2O4
Average molecular mass: 200.194 Da
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Non-NRP beta-lactam

Gene cluster description

alanylclavam (BGC0000841). Gene Cluster 1. Biosynthetic class = Other. GenBank CM000914, positions 1152119-1163141. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Kapil Tahlan (Memorial University of Newfoundland)

Literature references

1. Jensen SE et al. (2000) Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus. Antimicrob Agents Chemother 44(3):720-6.
2. Tahlan K et al. (2004) The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. J Bacteriol 186(18):6286-97. doi: 10.1128/JB.186.18.6286-6297.2004.
3. Tahlan K et al. (2007) 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus. Chem Biol 14(2):131-42. doi: 10.1016/j.chembiol.2006.11.012.
4. Kwong T et al. (2013) Carboxyethylarginine synthase genes show complex cross-regulation in Streptomyces clavuligerus. Appl Environ Microbiol 79(1):240-9. doi: 10.1128/AEM.02600-12. Epub
5. Tahlan K et al. (2004) Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus. Antimicrob Agents Chemother 48(3):930-9.
6. Kwong T et al. (2012) 5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus. Antimicrob Agents Chemother 56(9):4845-55. doi: 10.1128/AAC.01090-12.
7. Jensen SE et al. (2004) Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene. Antimicrob Agents Chemother 48(2):514-20.
8. Zelyas NJ et al. (2008) Alanylclavam biosynthetic genes are clustered together with one group of clavulanic acid biosynthetic genes in Streptomyces clavuligerus. J Bacteriol 190(24):7957-65. doi: 10.1128/JB.00698-08. Epub 2008 Oct