BGC0000842: carbapenem MM4550 biosynthetic gene cluster from Streptomyces argenteolus
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Location: 1 - 43,761 nt. (total: 43,761 nt).
This entry is originally from NCBI GenBank KF042303.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000842
Short description carbapenem MM4550 biosynthetic gene cluster from Streptomyces argenteolus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "UV spectrometry was used as further evidence that cabapenem MM 4550 was in fact the product of the BGC in question. Structure was drawn in chemdraw. Other cabapenem compounds are produced by orthologous genes in other Streptomycin species, but cabapenem MM 4550 is the only secondary metabolite product of this BGC."
Biosynthetic class(es)
  • other (non-nrp beta-lactam)
Loci
KF042303.1
1 - 43761
via Knock-out studies
Compounds
  • carbapenem MM4550
Species Streptomyces argenteolus [taxonomy]
References
Chemical products information
carbapenem MM4550 Evidence: NMR, Mass spectrometry
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C13H18N2O9S2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGU42409.1
 991 - 1668 (-) hypothetical protein
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    • AGU42410.1
    		 3166 - 4593 (+) arabinofuranosidase
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      • AGU42411.1
      • cmmSu
      		 5660 - 6700 (-) CmmSu
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        • AGU42412.1
        • cmmE
        		 6867 - 7715 (+) CmmE
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          • AGU42413.1
          • cmmF
          		 7747 - 8763 (-) CmmF
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            • AGU42414.1
            • cmmG
            		 8760 - 9551 (-) CmmG
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              • AGU42415.1
              • cmmH
              		 9784 - 10473 (+) CmmH
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                • AGU42416.1
                • cmmI
                		 10448 - 11848 (-) CmmI
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                  • AGU42418.1
                  • cmmJ
                  		 11969 - 13432 (-) CmmJ
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                    • AGU42417.1
                    • cmmK
                    		 13429 - 15471 (-) CmmK
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                      • AGU42419.1
                      • cmmL
                      		 15553 - 16725 (-) CmmL
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                        • AGU42420.1
                        • cmmM
                        		 16958 - 18337 (-) CmmM
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                          • AGU42421.1
                          • cmmN
                          		 18339 - 19448 (-) CmmN
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                            • AGU42422.1
                            • cmmO
                            		 19484 - 20887 (-) CmmO
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                              • AGU42423.1
                              • cmmP
                              		 20884 - 22332 (-) CmmP
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                                • AGU42424.1
                                • cmmQ
                                		 22757 - 23536 (+) CmmQ
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                                  • AGU42425.1
                                  • cmm17
                                  		 23533 - 24411 (+) Cmm17
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                                    • AGU42426.1
                                    • cmmR
                                    		 24387 - 25073 (-) CmmR
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                                      • AGU42427.1
                                      • cmmT
                                      		 25228 - 26394 (+) CmmT
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                                        • AGU42428.1
                                        • cmmS
                                        		 26387 - 27391 (-) CmmS
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                                          • AGU42429.1
                                          • cmmPah
                                          		 27704 - 28600 (+) CmmPah
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                                            • AGU42430.1
                                            • cmm22
                                            		 29339 - 30022 (+) Cmm22
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                                              • AGU42431.1
                                              • cmm23
                                              		 30019 - 31545 (+) Cmm23
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                                                • AGU42432.1
                                                • cmm24
                                                		 31482 - 32195 (+) Cmm24
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                                                  • AGU42433.1
                                                  • orf25
                                                  		 32511 - 35795 (-) Orf25
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                                                    • AGU42434.1
                                                    • orf26
                                                    		 36860 - 39949 (+) Orf26
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                                                      • AGU42435.1
                                                      • orf27
                                                      		 40883 - 41767 (-) Orf27
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                                                        • AGU42436.1
                                                        • orf28
                                                        		 42033 - 43220 (+) Orf28
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                                                          • AGU42437.1
                                                          • orf29
                                                          		 43246 - 43743 (-) Orf29
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                                                            Biosynthesis information
                                                            Annotation changelog

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Update compound structure (SMILES) for carbapenem MM4550
                                                            • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2019-10-16
                                                            Added compound information, update loci
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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