Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000843.1:
Cluster 1Other123666

BGC0000843, clavams biosynthetic gene cluster from Streptomyces clavuligerus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Alanylclavam
PubChem ID: 194618
ChemSpider ID: 168852
SMILES string: Copy to clipboard
Molecular formula: C8H12N2O4
Average molecular mass: 200.194 Da
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
Other biosynthetic class:
Non-NRP beta-lactam

Gene cluster description

clavams (BGC0000843). Gene Cluster 1. Biosynthetic class = Other. GenBank CM000913, positions 3437628-3461293. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
Contact for this cluster:Kapil Tahlan (Memorial University of Newfoundland)

Literature references

1. Goomeshi Nobary S, Jensen SE. (2012) A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tu1718 and Streptomyces clavuligerus. Can J Microbiol 58(4):413-25. doi: 10.1139/w2012-012. Epub 2012 Mar 21.
2. Marsh EN et al. (1992) Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry 31(50):12648-57.
3. Mosher RH et al. (1999) Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus. Antimicrob Agents Chemother 43(5):1215-24.
4. Salowe SP et al. (1990) Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis. Biochemistry 29(27):6499-508.
5. Tahlan K et al. (2004) Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus. Can J Microbiol 50(10):803-10. doi: 10.1139/w04-070.
6. Tahlan K et al. (2007) 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus. Chem Biol 14(2):131-42. doi: 10.1016/j.chembiol.2006.11.012.