BGC0000843: alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 3,437,628 - 3,461,293 nt. (total: 23,666 nt).
This entry is originally from NCBI GenBank CM000913.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000843
Short description alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (non-nrp beta-lactam)
Loci
CM000913.1
3437628 - 3461293
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • alanylclavam
  • 2-hydroxymethylclavam
  • 2-formyloxymethylclavam
  • clavam-2-carboxylate
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
alanylclavam Evidence:
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C8H12N2O4
Chemical database entries
PubCHEM
ChemSpider
2-hydroxymethylclavam Evidence:
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C6H9N1O3
Chemical database entries
PubCHEM
ChemSpider
2-formyloxymethylclavam Evidence:
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C7H9N1O4
Chemical database entries
PubCHEM
clavam-2-carboxylate Evidence:
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C6H7N1O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_2920
  • EFG07991.1
 3437628 - 3439310 (-) Putative serine-threonine protein kinase
  • Activation / processing
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  • SCLAV_2921
  • EFG07992.1
  • cvm9
 3439374 - 3439922 (-) DNA-binding protein
  • Activation / processing
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  • SCLAV_2922
  • EFG07993.1
  • cvm6
 3440280 - 3441638 (-) Putative pyridoxal phosphate-dependent aminotransferase
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    • SCLAV_2923
    • EFG07994.1
    • cvm5
    		 3441923 - 3443107 (+) Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase
    • Scaffold biosynthesis
    • Knock-out
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    • SCLAV_2924
    • EFG07995.1
    • cvm4
    		 3443162 - 3444148 (+) Alpha/beta hydrolase
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      • SCLAV_2925
      • EFG07996.1
      • cas1
      		 3444600 - 3445574 (-) Clavaminate synthase 1
      • Scaffold biosynthesis
      • Knock-out
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      • SCLAV_2926
      • EFG07997.1
      • cvm1
      		 3446153 - 3447187 (+) Aldo/keto reductase
      • Scaffold biosynthesis
      • Knock-out
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      • SCLAV_2927
      • EFG07998.1
      • cvm2
      		 3447624 - 3448079 (+) Hypothetical protein
      • Scaffold biosynthesis
      • Knock-out
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      • SCLAV_2928
      • EFG07999.1
      • cvm3
      		 3448076 - >3448586 (+) Flavin reductase-like protein
      • Precursor biosynthesis
      • Knock-out
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      • SCLAV_2929
      • EFG08000.1
      • cvm7
      		 3448733 - 3452077 (-) DnrI/RedD/AfsR-family transcriptional regulator
      • Activation / processing
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      • SCLAV_2930
      • EFG08001.1
      • cvm11
      		 3452469 - 3453119 (-) Putative translocator
      • Activation / processing
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      • SCLAV_2931
      • EFG08002.1
      • cvm12
      		 3453420 - 3454757 (+) Putative transcriptional regulatory protein
      • Activation / processing
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      • SCLAV_2932
      • EFG08003.1
      • cvm13
      		 3454884 - 3456056 (+) Beta-aspartyl-peptidase
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        • SCLAV_2933
        • EFG08004.1
        • cvmH
        		 3457202 - 3458158 (+) LanU-like protein
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          • SCLAV_2934
          • EFG08005.1
          • cvmP
          		 3458289 - 3460352 (-) putative protein-arginine deiminase
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            • SCLAV_2935
            • EFG08006.1
            • cvmG
            		 3460571 - 3461293 (+) Hypothetical protein
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              Biosynthesis information
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Updated bioactivity data
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: FHMX74FQXDJKCZZPHECQNTZR)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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