LOCUS       BGC0000844             13901 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptomyces clavuligerus clavulanic acid biosynthetic gene cluster,
            partial sequence.
ACCESSION   BGC0000844
VERSION     BGC0000844
KEYWORDS    .
SOURCE      Streptomyces clavuligerus
  ORGANISM  Streptomyces clavuligerus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     On Nov 13, 2003 this sequence version replaced AY258009.1.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:48:15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13901
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..13901
                     /db_xref="taxon:1901"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces clavuligerus"
     subregion       1..13901
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000844"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13901
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             <1..128
                     /codon_start=3
                     /note="ferridoxin"
                     /product="Orf11"
                     /protein_id="AAP13500.1"
                     /transl_table=11
                     /translation="DQDPETGIAVLLDATPPPELHESARLCAELCPCEAITVTEG"
     CDS             362..1738
                     /codon_start=1
                     /note="beta-lactamase like protein"
                     /product="Orf12"
                     /protein_id="AAP13501.1"
                     /transl_table=11
                     /translation="MMKKADSVPTPAEAALAAQTALAADDSPMGDAARWAMGLLTSSGL
                     PRPEDVAARFIPTFAAAGNFAETVREWRSKGPFTVRAYHPVAHKGWVVLSAPAGVRYIL
                     SLTLDSSGLIRILTLKPETVIPDMVTWNDVEETLHTPGVQHSVYAVRLTPDGHEVLHAS
                     APERPMPTGSAYKLYLMRALVAEIEKGTVGWDEILTLTPELRSLPTGDMQDLPDGTRVT
                     VRETAHKMIALSDNTGADLVADRLGREVVERSLAAAGHHDPSLMRPFLTSHEVFELGWG
                     DPERRAEWVRQDEAGRRELLEKMAGVMTVRGSDLGATVHQLGIDWHMDAFDVVRVLEGL
                     LQDSGRDTSGTVEEILTAYPGLLIDEERWRRVYFKAGSSPGVMMFCWLLQDHAGISYVL
                     VLRQSADEQRLIGDGLFLRGIGAKIIEAEAKLLSSGERRGAGTAAAGDDRASAGEAARR
                     "
     CDS             1735..2757
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 262.1; E-value: 1e-79)"
                     /gene_kind="transport"
                     /note="export pump"
                     /product="Orf13"
                     /protein_id="AAP13502.1"
                     /transl_table=11
                     /translation="MSVRDRLLACFVAVLWGLNFLAVRIGLDYYPPVFLSAMRFVVVAV
                     PVILFVPRPKVPLRWLLVYGLGFGVIQFGLLFLAIDIGMPSGQASVVVQAAAPFTMLLG
                     LLLGERISRRQAGGIVLAVAGMSAIAVERAQDAALLPLVLTLVAAFGWAMGNIASRQAR
                     PDHPLRFALWMCVLPPIPLLGLSAALEGPTAGWRALGDSLTSGDLTGPVALLYTALAGS
                     VVGSGIWNTLMKRYEAGTVAPFSMLVPVVAVAVATIWLDERLTLWSAVSGAAVVLGVLV
                     GTTRSRAAREAGPPPAAGRPPKAPAERGRMLRRRPPGPGDTGPDQSDGPASAVQNTQRS
                     "
     CDS             complement(2709..3728)
                     /codon_start=1
                     /note="acetyltransferase"
                     /product="Orf14"
                     /protein_id="AAP13503.1"
                     /transl_table=11
                     /translation="MNDTAGELEFVPLAANDDETVGQWLDLMALAAETGPRAAPPCNVD
                     MVGSLRFAPPATALDDWVVRSGGRVVGALRLALPDGAPTARVDQLLVHPGRRRRGIGRA
                     LWAHARELARKHDRTTLTATVVESLPSGPAQDPGPAAFAAAMGAHRSDIPAGTHQWLDL
                     DRHDPLADGVPAVPAGYSLVTWGTITPDEYAVPVSELELSLGAGPVDRAAQEVRTSYAR
                     QFETMRVGRGRRAYHTGAVHDATGALAGYTSVSKTTGNPAYALQGMTVVHREHRGHALG
                     TLLKLANLEYVLRHEPEVRLVETANAEDNHPMIAVNAALGFEPYDRWVFWTAEAGPSD"
     CDS             complement(3822..5510)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:extracellular
                     solute-binding protein family 5 (Score: 338.1; E-value:
                     1.7e-102)"
                     /gene_kind="transport"
                     /note="peptide transport protein"
                     /product="Orf15"
                     /protein_id="AAP13504.1"
                     /transl_table=11
                     /translation="MTTAARRPAPTTAGAGWDAGVGALVNPSRRRGGTLRLVSSADVDS
                     LDPARTYYVWVWLLQRLLNRTLMAYPTDPGPAGLVPAPDLAEGPGEVSDGGRTWTYRLR
                     RGLRYDDGTPITSDDVRHAVQRVFAQDVLPGGPTYLIPLLDDPERPYPGPYRTDEPLRS
                     VLTPDEHTIVFRLTRPFSDFDHLMAQPCAAPVPRRSDTGADYGRDPRSSGPYRVARHEP
                     DTLLHLERNPHWDRATDPIRPALPDRVELTIGLDVDVLDARLIAGEFDINLEGRGLQHA
                     AQRRATADEVLRSHTDNPRTSFLHFVAMQPHIPPFDNVHVRRAVQYAADKILLQDARGG
                     PVNGGDLTTALFPPTLPAHQDLDLYPTGPDLRGDLDAARAELAAAGLPDGFRAVIGTQR
                     GKFRLVADAVVESLARVGIELTVKELDVATYFSLGAGHPETVREHGLGLLVTDWGADFP
                     TEYGFLAPLVDGRQIKRNGGNWNLPELDDPEVNALIDETLHTTDPAARAELWRAVERRV
                     MEHAVLLPLVHDKTLHFRNPWVTNVYVHPAFGLYDIQAMGLAEED"
     CDS             complement(5507..6712)
                     /codon_start=1
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="hypothetical protein"
                     /product="Orf16"
                     /protein_id="AAP13505.1"
                     /transl_table=11
                     /translation="MSGDATLPVTDALPHTAADAVTDVVAVPDAAALPTSGWPDLVGPE
                     DFFQTPRWLAVQERNSGTTMDFLVRRRAGRPVAALVTAWGDDSVPWLLARPDAMLTRAL
                     EGEGEHPEAEARLADTAGGDPASLLPSLVCGGRHLGRTRPLAAPDALPSDVEALVAEAE
                     RLAKERGAATVCFPHVDDRDGALIGLLRSRGYVSHPSAHYAWLDIPPGGWDEFLADMTK
                     HRRRRVRLERRALDAAGIEVRIEPLTQEIVPRLGELDCNLLRKYGNPASPEHSAGLLSW
                     IAQVMGDDVMVSVARKDGVIIGFGMVLRSRARGREEWFGHRAGFDYEAQGRLPLYYDVL
                     YYRVLEAAAREGVTVLHAGIGSVEAKLARGCLASQEHSFLLRLPRTGETGTTDTDQKRT
                     AP"
     CDS             complement(6709..8022)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 181.8; E-value: 3.9e-55)"
                     /gene_kind="biosynthetic-additional"
                     /note="carboxylase"
                     /product="Orf17"
                     /protein_id="AAP13506.1"
                     /transl_table=11
                     /translation="MTTPLADYAKFAGKRIAIVEHMQNHPFVLGLHQAREHGLEVWLLT
                     GDRSWYTHGHDWDSHPLAAAVDRVVDVDTTDLAAVLAAVTDESGQCLVDGLTSFSDYHT
                     VIAAQAAQRLSLPGPDPEAVETANEKDRLRLALGDVPYNIPHARVSSREQLDEAVRKLG
                     FPMIAKPPAEAISYGVRRVDTMAELVEAYEELSGVRHSLRGQPRSGDVLLETYVEGVEV
                     SVETMTVDGYTHVFGVTSKDLFGDPAYIECGHTFPVPLSDEEREALYAAVRGTLEAIGY
                     RHGPCHTEVRRTETGWRIIEANPRTPSSCMTMLVTDVTGRSPILDAWLLTIGEAPPIEP
                     VVHNGGAAVRMIYPTRKGTLTRVDGIEAAAAVPGVQVLLHVEKGDKLLQRMDNSSCVGF
                     TYCAGADREEAQALADRAAGYLDFVVEEDERGERGGES"
     CDS             complement(8295..9779)
                     /codon_start=1
                     /note="penicillin binding protein"
                     /product="Orf18"
                     /protein_id="AAP13507.1"
                     /transl_table=11
                     /translation="MNRPLRHIAIFCGLLTLALLLRANWLQYVDAEELATHERNRRVQI
                     NQFATPRGDIIVGGGTSITGSKAVDGTDFKYQRTYKNGPMYAPVTGYASQSMGMSLLEN
                     TFDSVLSGQDDRLAIQRFTDVVTGKDRRGGNVITTIDPKAQQAAYKGLTALDARGSAVA
                     LDPKTGKVLALVSTPSYDPGVFAGNSLKESKRFRDLDKDKGKPLANRALRETFPPGSTF
                     KILTAAAALEHGVIDDIDAKTDAVSPYPLPQSTNTVGSEAGNAACDKVSLKTAMQHSCN
                     NVFLDAAVKLGVDKMRDTAEKFGFNEDVYSDAFGDMRAVKSLYPKELDKPGTALTGMGQ
                     GSLTSTPLQMAMVTAAIANNGKLMQPYIVDEVQSPDLSTLEKNEPREMSQAVSEETAGK
                     VREMMEFTAREGSARKALIDGVTVGGKTGTAQRGVDVREQVPYGWFVSYGEKDGQSVAV
                     AVFIDPTAMDISREDISGGGLGAPIARSVMKAVLEK"
     CDS             10386..12539
                     /codon_start=1
                     /note="penicillin binding protein"
                     /product="Orf19"
                     /protein_id="AAP13508.1"
                     /transl_table=11
                     /translation="MSNIPETGRTPRVRIRLVVVQILVVSLLLTLGGRLWHLQIREGER
                     YAEKASGNRVQRVVQPAVRGAILDARGAPIADNETRLVVSASRTELLKAPDRGRAVLTR
                     LAGVLGLPARELMDKVRLCDSKTPRPCWNGSPYQPIPLTDEATARQALQIRERSEQFPG
                     ITAEPTAVRRYPGPGGANTAQVLGYLSPVTDEELRAAQTSDSPYLRSDQVGRSGLERQY
                     DDILRGRAGITEYEVDHLGRVIGRSGDTPATPGANLITSIDARVQRIAEYELNEAMKAA
                     RKDWDRNTRRNYEADSGAVVVMEARTGRIVAMASNPSYDPNAWVGGISAKDYRKLTGEN
                     SNHPLLNRAIQGVAAPGSIFKVIPTVAAVNAGYPFDGRYECSSSYSIGGRSFGNFESKA
                     YGPIDLGRALEVSCDTVYYRLAHEEWRKDGGLTPKKGAKDWFYRTAHQFGLGKTTGVDL
                     PNEVTGRVPDHRWKQEYWEANKDSWCEHGKRDGTMLEQFSWENCRQGNQVRAGDSVNYS
                     IGQGDTLTTPIQMATIYAALANGGTLYTPSVGKAVVSADGRKIREIEPKAHGKLPMDRV
                     TRDKMDQALAGVATARGTAGWRFVGWPQEQIPIRAKTSTAEVFGKQTTSWFATYTDDYA
                     VVLTISQGGTGSGGSAPAVRKIYNALYGVAEDGTIDRSRALLPTPQRKLPAIRPDGSID
                     APRIRAYRPGAEGPAERPLRREP"
     CDS             12735..>13901
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 398.1; E-value:
                     6.8e-121)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative cytochrome P450"
                     /product="Orf20"
                     /protein_id="AAR16180.1"
                     /transl_table=11
                     /translation="MQTVPDYPGHTFAGSPVPLPREPVARVRLPSGDTVWLVTGYEEVR
                     TALTHPLLSRQVGADDPQVGSAGVIGGARGGVRTLQSDGAAHGAVRRLAARPFTPRRVA
                     RLRERIQGITDGLLDTMERSGSPADLVSSFAYPLPITVICELFAVPEGDRARFGVWSDR
                     IVTLLGISEQEVADARDALQGYLHELVTARRAEPGDDVVSGWLTADENGDRLTDDEVVR
                     LSQTVIIGGYETTVNSISAGMWRLFQHPEQLAAVRADPGLLRGTVEEILRYQPQGLFFL
                     IMVARGDLELGGVTIREGDGVMPLPNAANRDAARFADPARFDIHRPPGGHVAFGHGAHA
                     CLGSALARIELEVALGTLLGRFPGLRPAVADLDELAWRGDRLVCGLREL"
ORIGIN
        1 tcgaccagga ccccgagacg gggatcgccg tcctgctcga cgccactccc ccgcccgagc
       61 tgcacgagtc ggcccggctc tgtgccgagc tgtgcccgtg cgaggccatc acggtcaccg
      121 agggctaggt cgtgtcgtca aaatcccgtc tgcgtcgcga cgccttgcac gcacatctgc
      181 cgcgttgtcg tcagtcgccg atgctccgca tggactccct cctccgcctt gcatctgcac
      241 gcaccatgcg ccgcaccgcc cgtcctccgg acggacgacg ctattttgac gacactccct
      301 tgacagcctt ggcgccgttc cgcgcgcctc ccgcaccgtg gccgagggcc gacaaggagc
      361 gatgatgaag aaagctgatt ccgtcccgac cccggctgag gcggccctcg ccgcccagac
      421 cgcgctcgcg gccgacgact cccccatggg cgacgcggcc cgctgggcga tggggctgct
      481 gacctcgtcc ggactgcccc ggccggagga tgtggccgcg cgcttcatcc ccaccttcgc
      541 ggcggcgggg aacttcgcgg agaccgtgcg ggagtggcgg tcgaagggcc ccttcacggt
      601 ccgggcctac caccccgtcg cgcacaaggg ctgggtcgtg ctgtcggccc cggccggggt
      661 gcggtacatc ctgtcgctga cgctggactc cagcgggctg atccgcatcc tcaccctgaa
      721 gcccgagacc gtcatacccg acatggtcac gtggaacgat gtcgaggaga ccctccacac
      781 cccgggtgtg cagcactccg tgtacgcggt gcggctgacg cccgacgggc acgaggtgct
      841 gcacgcgtcg gcgccggagc ggccgatgcc gaccgggtcg gcgtacaagc tctatctgat
      901 gcgcgcgctc gtcgccgaga tcgagaaggg gacggtgggc tgggacgaga tcctcacgct
      961 cacgcccgag ctgcgcagcc tgcccacggg cgatatgcag gacctccccg acggcacccg
     1021 ggtgaccgtg cgggagaccg cgcacaagat gatcgcgctg agcgacaaca ccggcgccga
     1081 tctggtcgcg gaccggctgg gccgggaggt cgtggagcgc tccctggcag ccgcgggcca
     1141 ccacgacccg tccctgatgc gcccgttcct caccagccac gaggtcttcg agctgggctg
     1201 gggcgacccg gagcggcgcg cggagtgggt ccggcaggac gaggcgggcc gccgggagct
     1261 gctggagaag atggccgggg tgatgaccgt ccgcggctcc gacctgggcg cgacggtcca
     1321 tcagctcggc atcgactggc acatggacgc cttcgacgtg gtccgggtgc tggaggggct
     1381 gctccaggac agcggacggg acaccagcgg cacggtcgag gagatcctca ccgcctaccc
     1441 cggtctgctg atcgacgagg agcgctggcg ccgggtctac ttcaaggccg gttccagccc
     1501 cggtgtgatg atgttctgct ggctgctcca ggaccacgcg ggcatctcgt acgtcctcgt
     1561 cctgcggcag tcggccgacg agcagcggct catcggcgac ggtctgttcc tgcgcgggat
     1621 cggcgccaag atcatcgagg ccgaggcgaa gctgctcagc tccggtgagc gccgcggtgc
     1681 cgggaccgcg gcggccgggg acgaccgcgc gagcgccgga gaagccgccc ggcgatgagc
     1741 gtcagagacc ggctcctcgc ctgcttcgtg gcggtgctgt ggggcctgaa cttcctcgcc
     1801 gtgcgcatcg gcctcgacta ctaccctccg gtgttcctct ccgcgatgcg gttcgtggtc
     1861 gtggccgtgc cggtgatcct cttcgtgccc cggcccaagg tgcccctgcg ctggctgctg
     1921 gtgtacggac tgggcttcgg tgtgatccag ttcgggctgc tcttcctcgc catcgacatc
     1981 ggcatgccct cggggcaggc gtccgtggtg gtgcaggcgg cggccccgtt caccatgctg
     2041 ctcgggctgc tgctggggga gcgcatctcc cggcggcagg cgggcggcat cgtgctggcc
     2101 gtggccggga tgagcgccat cgcggtggaa cgggcgcagg acgcggccct gctgccgctg
     2161 gtgctgaccc tggtggcggc gttcggctgg gcgatgggca atatcgcgag ccggcaggcc
     2221 cgcccggacc atccgctgcg cttcgcgctc tggatgtgtg tgctgccgcc gatcccgctg
     2281 ctgggcctgt cggccgccct ggagggcccg acggcgggct ggcgggccct cggcgactcg
     2341 ctcacctccg gcgacctcac cggtccggtg gcgctgctgt acacggccct cgcgggctcc
     2401 gtggtcggct ccgggatctg gaacaccctg atgaaacggt acgaggcggg caccgtggcg
     2461 ccgttctcga tgctggttcc ggtggtcgcc gtcgcggtcg ccacgatctg gctggacgag
     2521 cggctgaccc tctggtcggc ggtgtccggc gcggccgtgg tgctgggcgt gctggtgggg
     2581 acgacccggt cgcgcgcggc ccgggaggcg ggcccgcccc cggccgccgg aaggccgccg
     2641 aaggccccgg cggaacgcgg ccggatgctg cggcggcgcc caccggggcc cggggacacg
     2701 ggtcccgatc agtcggacgg accggcctcg gcggtccaga acacccagcg gtcgtagggc
     2761 tcgaagccca gcgcggcgtt gacggcgatc atcgggtggt tgtcctcggc gttcgccgtc
     2821 tccacgagcc gcacctccgg ctcgtgccgc agcacgtact ccagattggc cagcttcagc
     2881 agggttccca gggcgtggcc gcggtgctca cggtgcacca cggtcatgcc ctggagcgcg
     2941 tacgcggggt tcccggtggt cttggagacg ctggtgtacc cggcgagagc gccggtggcg
     3001 tcgtggacgg cgccggtgtg gtacgcccgc cggccgcggc cgacccgcat ggtctcgaac
     3061 tgccgggcgt agctcgtcct gacctcctgc gcggccctgt cgacgggccc ggcgccgagc
     3121 gagagttcca gctcggagac cggcaccgcg tactcgtcgg gggtgatggt gccccaggtg
     3181 acgagggagt acccggcggg gaccgcgggg acgccgtccg ccagcgggtc gtgccggtcg
     3241 aggtcgagcc actggtgggt gcccgccggg atgtccgagc ggtgcgcgcc catcgcggcg
     3301 gcgaaggcgg ccgggcccgg gtcctgggcc gggccggagg gcagggactc gacgacggtc
     3361 gcggtgaggg tggtccggtc gtgcttgcgg gccagttccc gggcgtgggc ccagagcgcg
     3421 cggccgatgc cgcggcggcg ccgcccgggg tggaccagga gctggtcgac gcgggcggtc
     3481 ggggcgccgt cgggcagggc cagccgcagc gcgcccacca cccggccccc gctgcggacg
     3541 acccagtcgt cgagggcggt cgcgggcggg gcgaagcgca gcgagccgac catgtcgaca
     3601 ttgcaggggg gcgcggcccg ggggccggtc tcggcggcga gggccatcag gtcgagccac
     3661 tggccgaccg tttcgtcgtc gttcgccgcg agggggacga actccagttc gccggcggtg
     3721 tcgttcatgc gggtcccttg tgagtcggtc gggttcggtg ccgcgggccg ggcccggcgg
     3781 gggacgggtg cgccgtcccc cgccgggccc gggtgatgga cctagtcttc ttcggcgagg
     3841 cccatcgcct ggatgtcgta gaggccgaag gccgggtgga catagacgtt ggtgacccac
     3901 gggttgcgga agtgcagcgt cttgtcgtgg acgaggggca gcagcacggc gtgctccatc
     3961 acccggcgct ccacggcccg ccacagctcc gcgcgcgcgg cggggtcggt ggtgtgcagg
     4021 gtctcgtcga tcagcgcgtt gacctcgggg tcgtccagct cgggcaggtt ccagttgccg
     4081 ccgttgcgct tgatctggcg gccgtccacg agcggggcga ggaagccgta ctcggtgggg
     4141 aagtcggcgc cccagtcggt gacgaggagt ccgagcccgt gctcccggac ggtctcgggg
     4201 tgcccggcgc cgaggctgaa gtaggtggcg acgtcgagtt ccttgacggt cagctcgatg
     4261 ccgacccggg cgagcgactc cacgaccgcg tcggcgacca gccggaactt gccccgctgg
     4321 gtgccgatca ccgcccggaa gccgtccggg aggcccgccg ccgccagctc ggcccgcgcc
     4381 gcgtccaggt cgccgcggag gtccggcccc gtggggtaca gatccaggtc ctggtgggcg
     4441 gggagggtgg gcgggaagag cgccgtggtc aggtcgccgc cgttgaccgg gccgccgcgg
     4501 gcgtcctgga gcaggatctt gtccgccgcg tactgcaccg cgcggcgtac gtgcacattg
     4561 tcgaacgggg ggatgtgcgg ctgcatcgca acgaagtgga ggaagctcgt ccgggggttg
     4621 tccgtgtgcg agcgcagcac ctcgtccgcg gtggcccggc gctgggccgc gtgctggagc
     4681 ccccggccct ccaggttgat gtcgaactcc ccggcgatca gccgggcgtc caggacatcg
     4741 acgtccagac cgatggtcag ctccacccgg tccggcagcg cgggcctgat cgggtccgtc
     4801 gcccggtccc agtgcggatt gcgctccagg tggagcaggg tgtccggctc atggcgggcg
     4861 acccggtagg ggcccgacga gcgcgggtcg cggccgtagt cggcgccggt gtccgagcgc
     4921 cggggcacgg gcgccgcgca gggctgggcc atcagatggt cgaagtcgga gaacggccgg
     4981 gtcagccgga agacgatcgt gtgctcgtcg ggggtgagga ccgaccgcag cggctcgtcc
     5041 gtccggtacg gaccggggta gggccgctcg gggtcgtcca gcagcgggat gagataggtg
     5101 gggccgccgg gcagcacgtc ctgcgcgaac acccgctgca cggcgtggcg cacatcgtcc
     5161 gacgtgatcg gggtgccgtc gtcgtagcgc agcccccggc gcagccggta ggtccaggtc
     5221 cggccgccgt cgctgacctc gccggggccc tcggccaggt ccggggccgg gaccagtccg
     5281 gcggggccgg ggtcggtcgg ataggccatg agcgtacggt tcagcagccg ctggagcagc
     5341 cacacccaga cgtagtaggt gcgggccggg tcgagggagt cgacgtcggc cgaggagacg
     5401 agccgcaggg tcccgccgcg ccgccgcgag gggttcacca gcgcccccac cccggcgtcc
     5461 cagccggctc cggcggtcgt cggggccggt cgtcgcgcgg cggtggtcat ggtgcggtcc
     5521 tcttctgatc ggtgtcggtg gtgccggtct ccccggtgcg cggcaggcgc agcaggaacg
     5581 agtgctcctg gctggccaga cagccgcggg ccagcttcgc ctcgacgctg ccgatcccgg
     5641 cgtgcagcac ggtcacgccc tcgcgggcgg cggcctccag cacccggtag tacaggacgt
     5701 cgtagtagag cggcagcctg ccctgggcct cgtagtcgaa tccggcgcgg tggccgaacc
     5761 actcctcgcg gccccgggcc cgggagcgca gcaccatgcc gaagccgatg atcaccccgt
     5821 ccttgcgggc cacggagacc atcacgtcgt cgcccatgac ctgggcgatc cagctcagca
     5881 gccccgcgga gtgctcgggg ctcgccgggt tgccgtactt gcgcagcaga ttgcagtcga
     5941 gttcgccgag ccggggcacg atctcctggg tcagcggctc gatccgcacc tcgatgcccg
     6001 ccgcgtccag cgcccggcgc tccagccgga cccggcggcg gcggtgcttg gtcatgtcgg
     6061 ccaggaactc gtcccagccg ccgggcggga tgtcgagcca ggcgtagtgc gccgaggggt
     6121 gcgagacata gccgcgcgag cgcagcagcc cgatcagggc gccgtcgcgg tcgtcgacgt
     6181 gcgggaagca gacggtggcc gcgccccgct ccttcgcgag ccgctcggcc tcggcgacca
     6241 gcgcctccac gtcggacggc agcgcgtcgg gcgcggcgag cgggcgggtg cggcccagat
     6301 gccggccgcc gcacaccagc gagggcagca gcgaggcggg gtctcccccg gccgtgtcgg
     6361 cgagccgggc ctcggcctcg gggtgctccc cctcgccctc cagcgcccgg gtgagcatcg
     6421 cgtccgggcg ggccagcagc cagggcacgg agtcgtcgcc ccacgcggtc accagggccg
     6481 cgacgggacg gcccgcgcgg cggcggacca ggaagtccat cgtggtgccg gagttgcgct
     6541 cctgcaccgc cagccagcgg ggcgtctgga agaagtcctc cgggccgacg agatccggcc
     6601 agccgctggt ggggagggcg gcggcgtcgg gcaccgccac cacgtccgtc accgcgtccg
     6661 ccgccgtgtg cggcagcgcg tccgtcaccg gcagggtggc gtctccgctc acgactcccc
     6721 gccccgctcg ccccgctcgt cctcctcgac gacgaagtcc aggtatccgg ccgcgcggtc
     6781 cgcgagggcc tgggcctcct cccggtccgc cccggcgcag taggtgaagc cgacgcacga
     6841 ggagttgtcc atgcgctgga gcagcttgtc gcccttctcc acgtgcagca gcacctggac
     6901 cccgggcacc gcggccgcgg cctcgatgcc gtcgacccgg gtgagggtgc ccttccgggt
     6961 cgggtagatc atgcgcacgg cggcgccgcc gttgtggacg acgggctcga tcggcggggc
     7021 ctcgccgatc gtcagcagcc aggcgtcgag gatcgggctg cgcccggtga catcggtgac
     7081 cagcatcgtc atacagctcg acggggtgcg cgggttggcc tcgatgatcc gccagccggt
     7141 ctcggtgcgc cgcacctcgg tgtggcaggg gccgtgccgg tagccgatcg cctccagggt
     7201 gccccggacg gcggcgtaca gcgcctcgcg ctcctcgtcg gagaggggca ccgggaaggt
     7261 gtgcccgcac tcgatgtacg cggggtcgcc gaacaggtcc ttggaggtga ccccgaagac
     7321 atgggtgtac ccgtccacgg tcatcgtctc gacgctgacc tcgacgccct cgacataggt
     7381 ctccaggagg acatcgccgg agcgcggctg gccgcgcagg ctgtggcgga cgccggacag
     7441 ctcctcgtac gcctcgacca gctccgccat ggtgtcgacg cggcgcaccc cgtagctgat
     7501 ggcctcggcg ggcggcttgg cgatcatggg gaagccgagc ttccgtacgg cctcgtcgag
     7561 ctgctcgcgg ctgctgaccc gggcgtgcgg gatgttgtag gggacgtcgc cgagggcgag
     7621 gcgcagccgg tccttctcgt tcgccgtctc cacggcctcg gggtcggggc cgggcagcga
     7681 cagccgctgg gccgcctgcg cggcgatgac cgtgtggtag tcggagaacg aggtgagccc
     7741 gtcgaccagg cactgcccgc tctcgtcggt gacggccgcg agcacggccg ccagatcggt
     7801 ggtgtccacg tcgaccaccc ggtcgacggc cgccgcgagg gggtggctgt cccagtcgtg
     7861 cccgtgggtg taccaggacc ggtccccggt gagcagccag acctcaaggc cgtgctcacg
     7921 tgcctggtgg agccccagga cgaaggggtg gttctgcatg tgctcgacga tcgcgatgcg
     7981 cttgcccgcg aacttggcat agtcggccag gggtgtggtc atcgaaccgc ctccgtcatg
     8041 acgctgttca gtcgactcga ctcggataca caggctccag ttgaccgcgc cgatcacgtt
     8101 cgggacacgg ttacggacgc ggtgtgcata ggctgtgagc gaggcgcata ggaaggcggc
     8161 cggcggggcc cgcgcgggcc gcgcggcatg ccggaaaagc ccgatggctc ccgccctcgg
     8221 ggggtgggag ccatcgtcgt cggaaagccg ggccgcgggg cccgggaacg ggccgggggc
     8281 cggggccccg ggggtcactt ctccaggacg gccttcatca cactgcgggc gatgggcgcg
     8341 cccagaccgc cgccggagat gtcctcacgg gagatgtcca tcgcggtcgg gtcgatgaag
     8401 acggccaccg ccacggactg gccgtccttc tccccgtagg agacgaacca gccgtacggg
     8461 acctgctcgc gcacatcgac accgcgctgc gcggtaccgg tcttgccgcc caccgtgacg
     8521 ccgtcgatca gcgccttgcg ggcgctgccc tccctggcgg tgaactccat catctcccgg
     8581 accttgcccg cggtctcctc ggagacggcc tggctcatct cccggggctc gttcttctcc
     8641 agggtgctca gatcggggga ctgcacctcg tcgacgatgt acggctgcat cagcttgccg
     8701 ttgttggcga tggcggcggt gaccatggcc atctgcaagg gggtgctggt gaggctgccc
     8761 tgtcccatac cggtcagcgc ggtgcccggc ttgtccagtt ccttggggta caggctcttg
     8821 acggcccgca tgtcgccgaa ggcgtccgag tagacgtcct cgttgaaccc gaacttctcg
     8881 gcggtgtcgc gcatcttgtc cacgcccagc ttgaccgcgg cgtcgaggaa gacattgttg
     8941 caggaatgct gcatggcggt cttcagcgag accttgtcgc aggccgcgtt gcccgcctcg
     9001 ctgccgaccg tgttggtcga ctgcggcagc ggatacgggg acaccgcgtc ggtcttcgcg
     9061 tcgatgtcgt cgatcacccc gtgctccagg gccgccgccg ccgtgaggat cttgaacgtg
     9121 gagccgggcg ggaaggtctc ccgcagcgcg cggttggcca gcggcttgcc cttgtccttg
     9181 tccaggtccc ggaaccgctt gctctccttg aggctgttgc ccgcgaagac accggggtcg
     9241 taggacgggg tcgagaccag ggcgagcacc ttgcccgtct tcgggtcgag cgccacggcc
     9301 gagccccggg cgtccagggc ggtgagcccc ttgtacgcgg cctgctgcgc cttggggtcg
     9361 atcgtggtga tcacattgcc gccgcgccgg tccttgccgg tgacgacgtc ggtgaagcgc
     9421 tggatcgcga gccggtcgtc ctgcccgctc aatacgctgt cgaacgtgtt ctccagcagc
     9481 gacatgccca tggactgcga ggcgtacccg gtgacgggcg cgtacatggg gccgttcttg
     9541 taggtgcgct ggtacttgaa gtcggtgccg tcgacggcct tcgacccggt gatggaggta
     9601 ccgccaccca cgatgatgtc gccgcgcggg gtcgcgaact ggttgatctg gacccggcgg
     9661 ttgcgctcgt gcgtggccag ttcctcggcg tccacgtact gcagccagtt ggctctcagc
     9721 agcagcgcga gtgtcagcag cccgcagaag atggctatgt gccgcagcgg cctgttcatg
     9781 gagcacctcc tccggccgcc ggaacgctcc cggccggccg gccgtcgatc gcgaccgcct
     9841 gttccggcgg gagaaccggg cggacagggg tcagagtgga aagcaccata caagcacctt
     9901 agttgaacgg cccgggtgcc gaacgggtcc cccggccctg caccgcgggc gaaaaatacc
     9961 ggtcctccgg ggggctcggc gggccgtgcg gaggcggaat cgagaggacc cccaggacag
    10021 gatacgaagc ggcgaatggc gcgatatcgc gggtgtccgg ggagcggccg acgcggaacg
    10081 cggcccctca cctaggctct gtcccgaggg ccgccccgcc cggcccggga ggactccggg
    10141 attcccggga atcccggaga accgccggag ccccgggcgc atctttcccc ggggagccgg
    10201 aggacggcgg gggccggggc cgccgggaac cggaagggcg ggccctgtgg gctccgtcac
    10261 ttccgtacgc tgggacggac ggccggacag ccgggcggga agccggaccg gacgccggac
    10321 cggaccggcg ggggcgcccg gccggggcac cgagggcgac gagggcacac agcagggggc
    10381 agcagatgag caatatcccg gagaccggcc ggactccgag ggtccggata cggctcgtgg
    10441 tcgtccagat actggtggtc tccctgctgc tgaccctcgg cggccggctc tggcacctcc
    10501 agatccggga gggcgagcgg tacgcggaga aggcgtcggg gaaccgggtc cagcgggtcg
    10561 tccagcccgc cgtgcgcggc gccatcctcg acgcgcgcgg ggccccgatc gcggacaacg
    10621 agacccggct ggtcgtctcc gcctcccgga ccgagctgct gaaggcgccg gaccggggca
    10681 gggccgtgct gacccggctc gccggggtcc tcggcctgcc cgcgcgggag ctgatggaca
    10741 aggtccggct gtgcgacagc aagacccccc ggccctgctg gaacggctcg ccgtaccagc
    10801 ccatcccgct caccgacgag gccaccgccc ggcaggcgct ccagatccgc gagcgctccg
    10861 agcagttccc cggcatcacc gccgagccca ccgccgtgcg ccgctacccc ggccccggcg
    10921 gcgccaacac cgcgcaggta ctcggctacc tctcccccgt caccgacgag gaactgcggg
    10981 ccgcgcagac gtccgactcc ccctacctcc gctccgacca ggtggggcgc agcggtctgg
    11041 agcggcagta cgacgacatc ctgcgcggca gggcgggcat caccgaatac gaggtcgacc
    11101 atctcggccg ggtcatcggc cgctccggcg acacccccgc gacccccggc gccaacctga
    11161 tcaccagcat cgacgcccgg gtgcagcgga tcgccgagta cgagctgaac gaggccatga
    11221 aggccgcccg caaggactgg gaccgcaaca cccgcaggaa ctacgaggcc gactccggcg
    11281 cggtcgtcgt gatggaggcg aggacgggcc gcatcgtcgc catggcgtcc aatccgtcct
    11341 acgaccccaa cgcctgggtc ggcggcatat ccgccaagga ctaccggaag ctcaccggtg
    11401 agaactccaa ccacccgctg ctgaaccggg cgatccaggg cgtggcggcc cccggctcga
    11461 tcttcaaggt cataccgacg gtggccgccg tcaacgcggg ctaccccttc gacgggcggt
    11521 acgagtgctc cagctcgtac tcgatcggcg gccggtcctt cgggaacttc gagtccaagg
    11581 cgtacggccc catcgacctc ggccgcgccc tggaggtctc ctgcgacacc gtgtactacc
    11641 gcctcgccca cgaggagtgg cgcaaggacg gcggcctcac cccgaagaag ggcgcgaagg
    11701 actggttcta caggaccgcc caccagttcg gcctcgggaa gacgaccggc gtcgacctgc
    11761 cgaacgaggt caccggccgg gtccccgacc accggtggaa gcaggagtac tgggaggcga
    11821 acaaggactc ctggtgcgag cacggcaagc gcgacggcac catgctggag cagttctcct
    11881 gggagaactg ccgccagggc aaccaggtcc gcgccggtga ctccgtgaac tactccatcg
    11941 gccagggcga caccctcacc acccccatcc agatggcgac gatctacgcg gccctcgcca
    12001 acggcggcac cctctacacg ccgagcgtgg gcaaggcggt cgtcagcgcc gacggccgga
    12061 agatccggga gatcgagccg aaggcgcacg ggaagctgcc catggaccgg gtgacccgcg
    12121 acaagatgga ccaggccctg gccggggtcg cgaccgcccg gggcacggcg ggctggcggt
    12181 tcgtcggctg gccgcaggag cagatcccga tccgggccaa gacgagcacc gccgaggtct
    12241 tcggcaagca gaccacctcg tggttcgcca cctacaccga cgactacgcg gtcgttctga
    12301 cgatctccca gggcggtacg ggctccggcg gctccgcccc cgccgtccgc aagatctaca
    12361 acgcgctgta cggcgtcgcg gaggacggca ccatcgaccg ttcccgggcg ctgctcccca
    12421 ccccgcagcg gaagctgccc gcgatccggc ccgacggctc catcgacgcg ccgaggatcc
    12481 gggcgtaccg gcccggggcc gaggggcccg cggagcggcc cctgcggcgc gagccctgag
    12541 agccggggcg gacgcgccga tccggcacac ggtccgggcc cggggtctgg gatccgggct
    12601 caggtccggg gtctgaggtc cgggcctcgc ggggcccggc cggggtgaac cggccgggcc
    12661 cccggtccgt gggtgcgggc aaggagtccg cgctaccggc ggagcacccg cgcgcgggcg
    12721 gcgaaggagg ctcgatgcag acggtccccg actaccccgg ccacaccttc gccgggagcc
    12781 ccgtcccgct gccccgggaa cccgtggccc gggtgcggct gcccagcggc gacaccgtct
    12841 ggctggtcac cgggtacgag gaggtgcgca ccgcgctgac ccatccgctg ctctcccggc
    12901 aggtgggcgc ggacgatccg caggtgggct cggcgggggt gatcggcggc gcccggggcg
    12961 gcgtacggac cctccagagc gacggggccg cgcacggcgc ggtacggcgg ctggcggccc
    13021 ggccgttcac cccgcgcagg gtcgcccggc tgcgggagcg catccagggg atcaccgacg
    13081 gcctcctcga caccatggag cggtccggct ccccggcgga cctcgtctcc tcgttcgcgt
    13141 atccgctgcc gatcacggtg atctgcgagc tgttcgccgt gccggagggg gaccgggccc
    13201 gcttcggcgt ctggtcggac cggatcgtca ccctgctcgg catcagcgag caggaggtgg
    13261 ccgacgcccg ggacgccctc cagggctatc tgcacgagct ggtgaccgcc cggcgggccg
    13321 aacccggcga cgatgtcgtc agcggctggc tgacggccga cgagaacggc gaccggctca
    13381 ccgacgacga ggtggtccgg ctctcccaga cggtgatcat cggcggctac gagacgaccg
    13441 tgaactccat cagcgccggt atgtggcggc tcttccagca cccggagcag ctcgcggcgg
    13501 tgcgcgcgga ccccgggctg ctgcgcggca ccgtcgagga gatcctccgg tatcagccgc
    13561 aggggctctt cttcctgatc atggtggccc ggggcgatct ggagctgggc ggggtgacca
    13621 tccgggaggg ggacggggtc atgccgctgc ccaacgccgc caaccgggac gccgcccgct
    13681 tcgccgaccc ggcccgcttc gacatccacc ggccgcccgg cggacatgtc gccttcggcc
    13741 atggggcgca cgcctgtctg ggctccgcgc tggcccgcat cgagctggag gtggcgctcg
    13801 ggacgctgct cggccgcttc ccggggctgc ggcccgccgt cgccgacctg gacgagctgg
    13861 cctggcgcgg cgaccggctg gtgtgcgggc tgagggagct c
//
