LOCUS       BGC0000849              1710 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0000849
VERSION     BGC0000849
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 14:19:01
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 6890527
            Orig. end    :: 6892237
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..648)
                     /gene="SCO6265"
                     /gene_synonym="SCAH10.30c"
                     /gene_synonym="scbR"
     CDS             complement(1..648)
                     /codon_start=1
                     /db_xref="GOA:Q7AKF1"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR011075"
                     /db_xref="InterPro:IPR015893"
                     /db_xref="InterPro:IPR023772"
                     /db_xref="UniProtKB/TrEMBL:Q7AKF1"
                     /gene="SCO6265"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 75.6; E-value: 1.1e-22)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCAH10.30c"
                     /gene_synonym="scbR"
                     /note="SCAH10.30c, scbR, gamma-butyrolactone binding
                     protein, len: 215 aa; identical to previously sequenced
                     TR:O86852 (EMBL:AJ007731) Streptomyces coelicolor
                     gamma-butyrolactone binding protein, 215 aa and to
                     TR:O24741 (EMBL:AB001683) Streptomyces sp. FarA, 221 aa;
                     fasta scores: opt: 771 z-score: 937.4 E(): 0; 57.2%
                     identity in 208 aa overlap. Contains match to Pfam entry
                     PF00440 tetR, Bacterial regulatory proteins, tetR family
                     and to Prosite entry PS01081 Bacterial regulatory proteins,
                     tetR family signature. Contains also a possible
                     helix-turn-helix motif at residues 30..51 (+3.66 SD)"
                     /product="gamma-butyrolactone binding protein"
                     /protein_id="CAB60184.1"
                     /transl_table=11
                     /translation="MAKQDRAIRTRQTILDAAAQVFEKQGYQAATITEILKVAGVTKGA
                     LYFHFQSKEELALGVFDAQEPPQAVPEQPLRLQELIDMGMLFCHRLRTNVVARAGVRLS
                     MDQQAHGLDRRGPFRRWHETLLKLLNQAKENGELLPHVVTTDSADLYVGTFAGIQVVSQ
                     TVSDYQDLEHRYALLQKHILPAIAVPSVLAALDLSEERGARLAAELAPTGKD"
     subregion       1..1710
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..1710
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    complement(469..609)
                     /gene="SCO6265"
                     /gene_synonym="SCAH10.30c"
                     /gene_synonym="scbR"
                     /note="Pfam match to entry PF00440 tetR, Bacterial
                     regulatory proteins, tetR family, score 55.50, E-value
                     1.1e-13"
     misc_feature    complement(481..573)
                     /gene="SCO6265"
                     /gene_synonym="SCAH10.30c"
                     /gene_synonym="scbR"
                     /note="PS01081 Bacterial regulatory proteins, tetR family
                     signature"
     regulatory      complement(654..658)
                     /regulatory_class="ribosome_binding_site"
     gene            766..1710
                     /gene="SCO6266"
                     /gene_synonym="SCAH10.31"
                     /gene_synonym="scbA"
     CDS             766..1710
                     /codon_start=1
                     /db_xref="InterPro:IPR005509"
                     /db_xref="InterPro:IPR029069"
                     /db_xref="UniProtKB/TrEMBL:Q7AKF0"
                     /gene="SCO6266"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCAH10.31"
                     /gene_synonym="scbA"
                     /note="SCAH10.31, scbA, len: 314 aa; identical to
                     previously sequenced TR:O86851 (EMBL:AJ007731) Streptomyces
                     coelicolor ScbA protein, 314 aa and to SW:AFSA_STRGR
                     (EMBL:M24250) Streptomyces griseus possible A-factor
                     biosynthesis enzyme AfsA, 301 aa; fasta scores: opt: 1345
                     z-score: 1570.4 E(): 0; 66.1% identity in 292 aa overlap"
                     /product="ScbA protein"
                     /protein_id="CAB60185.1"
                     /sec_met_domain="AfsA (E-value: 5.1e-29, bitscore: 87.5,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEAVVLINSASDANSIEQTALPVPMALVHRTRVQDAFPVSWIPK
                     GGDRFSVTAVLPHDHPFFAPVHGDRHDPLLIAETLRQAAMLVFHAGYGVPVGYHFLMAT
                     LDYTCHLDHLGVSGEVAELEVEVACSQLKFRGGQPVQGQVDWAVRRAGRLAATGTATTR
                     FTSPQVYRRMRGDFATPTASVPGTAPVPAARAGRTRDEDVVLSASSQQDTWRLRVDTSH
                     PTLFQRPNDHVPGMLLLEAARQAACLVTGPAPFVPSIGGTRFVRYAEFDSPCWIQATVR
                     PGPAAGLTTVRVTGHQDGSLVFLTTLSGPAFSG"
ORIGIN
        1 tcagtccttc ccggtcggtg ccagttcggc cgcgaggcgt gctccgcgct cctcggagag
       61 atcgagcgcg gccagcacgg agggaaccgc gatggcgggc aggatgtgct tctgcagcag
      121 cgcgtagcgg tgttcgaggt cctggtagtc gctgaccgtc tgggacacga cctgtatccc
      181 ggcgaacgtg cccacgtaga gatcggccga gtcggtggtg accacatggg gcagcaactc
      241 accgttctcc ttggcctggt tcagcagctt caggagtgtc tcgtgccagc gacggaaggg
      301 tcctcggcga tcgagaccgt gcgcctgctg gtccatggag aggcgcacgc cggcccgggc
      361 cacgacgttc gtgcgcaagc ggtgacagaa caacatgccc atgtcgatga gttcttgcag
      421 ccggaggggt tgctccggaa cggcctgtgg tggttcctgg gcgtcgaaga cgcccagcgc
      481 cagttcttcc ttggactgga agtggaagta gagggctccc ttggtcaccc cggccacctt
      541 gaggatctcc gtgatcgtgg cagcttggta gccctgcttc tcgaagacct gcgccgcggc
      601 gtccaggatc gtctgccgcg tgcggatcgc ccggtcctgc ttggccatgc ctgcctcctt
      661 gttcatgtct cccccgggaa ggatagaaaa aaaaccgctc agtctgtatc ttaacgttcg
      721 cgcatacaga acagctcggc atcacatgat tcctgggggg gacccatgcc cgaagcagta
      781 gttttgatca attctgcgtc cgatgccaac tcgatcgaac aaaccgcatt gccggttccg
      841 atggcgcttg tccaccggac cagggtgcag gacgcgttcc cggtcagctg gataccgaag
      901 ggcggtgacc ggttctcggt caccgccgtc ctgccccacg accacccgtt cttcgcaccg
      961 gtccacgggg accgacacga tccgctgctg atcgccgaga ccctgcgtca ggcggcgatg
     1021 ctcgtcttcc acgccggcta cggcgtgccg gtgggctacc acttcctgat ggccacgctg
     1081 gactacacct gccacctcga ccacctcggc gtgtcgggcg aggtcgcgga gctggaggtg
     1141 gaagtggcct gttcccagct gaagttccgc ggcgggcagc ccgtacaggg acaggtggac
     1201 tgggccgtgc gccgcgccgg acggctcgct gccacgggga ctgccacgac gcgcttcacc
     1261 agtcctcaag tctaccggcg gatgcgcggc gacttcgcga ctcccaccgc atcggtgccc
     1321 gggaccgcgc ccgtgcccgc ggcgcgcgcc ggtcgcaccc gcgacgagga cgtggtcctg
     1381 tcggcgagtt cgcagcagga cacgtggcga ctgcgggtgg acaccagtca cccgaccctc
     1441 ttccagcgcc ccaacgacca cgtaccgggc atgctgctgc tcgaggcggc acggcaggcg
     1501 gcgtgcctcg tgaccggtcc ggcgcccttc gtgccgtcga tcggcggcac ccggttcgtc
     1561 cggtacgcgg agttcgacag cccgtgctgg atccaggcga cggtccggcc ggggccggcg
     1621 gcggggctga ccaccgtgcg ggtcaccggg catcaggacg gcagcctcgt cttcctcacc
     1681 acgctgtccg gccccgcgtt ctccggctga
//
