LOCUS       BGC0000861             20498 bp    DNA     linear   BCT 06-NOV-2009
DEFINITION  Shewanella sp. BR-2 eicosapantaenoic acid synthesis gene cluster,
            complete sequence.
ACCESSION   BGC0000861
VERSION     BGC0000861
KEYWORDS    .
SOURCE      Shewanella sp. BR-2
  ORGANISM  Shewanella sp. BR-2
            Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
            Shewanellaceae; Shewanella.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:51:00
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 20498
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..894)
                     /NRPS_PKS="Domain: ACPS (125-187). E-value: 1.3e-15. Score:
                     49.3. Matches aSDomain: nrpspksdomains_ACI12946.1_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 237.2;
                     E-value: 2.3e-72)"
                     /gene_kind="biosynthetic-additional"
                     /product="4'-phosphopantetheinyl transferase"
                     /protein_id="ACI12946.1"
                     /transl_table=11
                     /translation="MTDSLTSSKNGVNVDLFFIPLNDMSAAQTSLAESWLSDDELAKVR
                     RYRDPKAQIKGLQVRAALRAVLSRYADLSPHEWCFEYGAKGKPSLTATLQQQTGLEFNL
                     SHSGDWLLIGVAQFDGVESVLFGVDIERSRPKTDIYPILNHYFSPQETVALLALADEAS
                     QRQRFFDLWALKESYIKATGLGLAQSLKSFAFELKPFEQLAAESLELSCQDAGLRQACG
                     VASMLNVYPHISLKIPLQIPIHTLDLADSLLWQTHFGRLTEEYRFAISLAHAGNAALPI
                     TLTAQLSSIEVLLADY"
     source          1..20498
                     /db_xref="taxon:563072"
                     /host="Sardinops melanostictus (sardine)"
                     /isolation_source="intestine of marine fish"
                     /mol_type="genomic DNA"
                     /organism="Shewanella sp. BR-2"
                     /strain="BR-2"
     misc_feature    1..20498
                     /note="eicosapantaenoic acid synthesis gene cluster; EPA
                     gene cluster"
     subregion       1..20498
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20498
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        complement(334..519)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACI12946.1_ACPS.1"
                     /evalue="1.30E-15"
                     /label="ACI12946.1_ACPS.1"
                     /locus_tag="ACI12946.1"
                     /protein_end="187"
                     /protein_start="125"
                     /score="49.3"
                     /tool="antismash"
                     /translation="FGVDIERSRPKTDIYPILNHYFSPQETVALLALADEASQRQRFFD
                     LWALKESYIKATGLGLA"
     CDS             1546..2415
                     /codon_start=1
                     /product="transcriptional regulator"
                     /protein_id="ACI12947.1"
                     /transl_table=11
                     /translation="MATRDSQSKAPSYAPKSTTPAAQKDSTPRHRNATTTPEMRLFIQQ
                     SDLSVSQLAKILNITEATVRKWRKRESISNSSNTPHHLNTTLTPMEEYVVVGLRYQLRL
                     TLDRLLHVTQTYINPNVSRSGLARCLKRYGISRLDEFEAPQVPERYFNQLPVTQGSDIQ
                     TYTVNPETLAKALALPSTDGDTVVQVVSLTIPPQLTEQAPSSVLLGIDTASDWIYLDIY
                     QDSNTQATNRYIAYVLRHGPFHLRKLLVRNYHTFLARFPGAHGTPKTNAAEPQNKVTVS
                     RSTRGDSL"
     gene            2412..10490
                     /gene="pfaA"
     CDS             2412..10490
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (28-482). E-value:
                     9e-116. Score: 379.0. Matches aSDomain:
                     nrpspksdomains_pfaA_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (607-925). E-value: 2.2e-62.
                     Score: 202.9. Matches aSDomain:
                     nrpspksdomains_pfaA_PKS_AT.1"
                     /NRPS_PKS="Domain: PP-binding (1272-1340). E-value: 1e-12.
                     Score: 40.3. Matches aSDomain:
                     nrpspksdomains_pfaA_PP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (1373-1441). E-value: 1e-12.
                     Score: 40.3. Matches aSDomain:
                     nrpspksdomains_pfaA_PP-binding.2"
                     /NRPS_PKS="Domain: PP-binding (1480-1547). E-value:
                     1.8e-12. Score: 39.5. Matches aSDomain:
                     nrpspksdomains_pfaA_PP-binding.3"
                     /NRPS_PKS="Domain: PP-binding (1582-1650). E-value:
                     4.4e-13. Score: 41.5. Matches aSDomain:
                     nrpspksdomains_pfaA_PP-binding.4"
                     /NRPS_PKS="Domain: PP-binding (1689-1756). E-value:
                     1.7e-12. Score: 39.6. Matches aSDomain:
                     nrpspksdomains_pfaA_PP-binding.5"
                     /NRPS_PKS="Domain: PKS_KR (2059-2280). E-value: 5.5e-47.
                     Score: 151.9. Matches aSDomain:
                     nrpspksdomains_pfaA_PKS_KR.1"
                     /codon_start=1
                     /gene="pfaA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hglE-KS: hglE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 178.7; E-value: 3.5e-54)"
                     /gene_kind="biosynthetic"
                     /note="EPA synthase"
                     /product="PfaA"
                     /protein_id="ACI12948.1"
                     /sec_met_domain="PP-binding (E-value: 4.8e-14, bitscore:
                     41.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2.4e-63, bitscore: 202.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="hglE (E-value: 5e-234, bitscore: 764.8,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHTPSVPNSATESKKDKRLNKRLKDMPVAIVGMASIFANSRYLN
                     KFWDLISEKIDAITDIPDTHWRAEDYYDADKSKADKSYCKRGGFLPEVDFNPMEFGLPP
                     NILELTDTSQLLSLIVAKEVLADANLPTDYDRDRIGITLGVGGGQKISQSLNSRLQYPV
                     LKKVFKSSGLSDEDSEMLIKKFQDQYIHWEENSFPGSLGNVIAGRIANRFDFGGMNCVV
                     DAACAGSLAAMRMALTELTEGRSDMMITGGVCTDNSPSMYMSFSKTPAFTTNETIQPFD
                     IDSKGMMIGEGIGMVALKRLEDAERDGDRIYAVIKGVGASSDGKFKSIYAPRPEGQAKA
                     LERAYDDAGFAPHSIGLVEAHGTGTAAGDVAEFNGLKSVFAQGNDTNQHIALGSVKSQV
                     GHTKSTAGTAGVIKAALALHHKVLPATINVSQPNPKLNIESSPFYLNTETRPWFQRADA
                     TPRRAGVSSFGFGGTNFHLVLEEYKPEHSRDEQYRQRSVPQTLLFAAANKAALLSELKA
                     ALSQSVNTNANKSSAASLNAIAQQYPLRTLASTDARLGFVAKDIAQLQAQLNQSIAHLE
                     TNAIEVWQLPSGISYRSHALVAKNESKKVAALFAGQGSQYLNMGRELACHFPEMRQQVM
                     ASDKAFAHHGQTPLSNILYPIPAFDADAVKAQEAALTNTLFAQSAIGAISMAQYSLLTQ
                     AGFAPDMVAGHSFGELSALCAAGVISNEDYVELAFARGHAMAQVPSDTASKAADTGTQT
                     DLGTMFAIILKQKNDIDALNSCLAQFDGVKIANYNAPTQLVIAGGTEQTQLAAKAISEL
                     GFKAIALPVSGAFHTPLVGHAQKPFAKAIDKAKFSAPSVALYANGTGQLHPTDGKAIKA
                     EFKQHMLQSVRFSEQLQAMYDAGARVFVEFGPKNILQKLVENTLGEHLNELCLVSMNPN
                     PKGDSDSQLRLAAVQLAVAGVALTEVDPYQAITSQEIAEREAPSAMNIKLTATNHISAA
                     TKAKMAKSLATGSVTSQVQYVDRIVETVVEKEVEKIVEKQVIVEKVVEKIIEVEANQVA
                     AVEMKQTSPSVVQGLSNHQQQATAQLSPNTPNISSDALTAFFSAQSHVAQLHQQFLAIP
                     QQYGDTFTTLMTEQAKMASQGITIPESLQRSMEMFHQHQAQTLQSHAEFMQLQSSSSQA
                     ALAMLNNAPINFTPAVASQPRVTAPAPAPVAASTVAHNAAPVAAQAVATRPAVSTPIPP
                     VVQTAPVAFAPAVTVQVAPAAPVLVMPEMTSVAPATSSLSAALVQQTMMAVVADKTGYP
                     TEMLELGMDMEADLGIDSIKRVEILGTVQDELPGLPELSPEDLAECRTLGEIVDYMNSK
                     LPAAGQVVVSTTAPTAPAANGLSAALVQQTMMAVVADKTGYPTEMLELGMDMEADLGID
                     SIKRVEILGTVQDELPGLPELSPEDLAECRTLGEIVDYMNSKLPVVSVVAVAPPANVEA
                     TPAQIPANNGLSAALVQQTMMAVVADKTGYPTEMLELGMDMEADLGIDSIKRVEILGTV
                     QDELPGLPELSPEDLAECRTLGEIVNYMNSKLPAVGSVIVATHVTAAAPAASGLSAALV
                     QQTMMAVVADKTGYPTEMLELSMDMEADLGIDSIKRVEILGTVQDELPGLPELNPEDLA
                     ECRTLGEIVDYMNSKLPVISAVAVAPAANVEATPAQVPANNGLSAEKVQQTMMAVVADK
                     TGYPTEMLELSMDMEADLGIDSIKRVEILGTVQDELPGLPELNPDDLAECRTLGEIVSY
                     MQGKLGQNVAPISAVAAEPAIDLPPHDLPPHSEVVLKKLPAAAELTQQSAQKALPRVFA
                     KDACIIISDDGHNAGVLAEKLHAQGLTVAVVRSPESLVASASPLNSHIASFTLAAIDDA
                     SISAVINEIKSLGQVAGFIHLQPQHKTSADAKGLVLSSAAKASVEQAFLFAKHLQPLLT
                     TAATANTDSSFISVSRIDGGFGYLNHSQIARSELNQAALAGLTKTLSHEWPSVHCRALD
                     IAPALDAKQLANAVIAELFATDKLLEVGVSESSVSEAGATETLARVTLVAGKADTRHGA
                     ANLTSADKILVTGGAKGVTFECALSLAKRSKAHFILAGRSSQQAIPAWAQGKNNSELKA
                     AAIAHIQSLGEKPTPKQVDALVWPVQSSQEIAAALQAFTAVGASAEYLSLDVNNPDAIA
                     STIVPITELSPITGIIHGAGVLADKHIQDKTLDELARVYGTKVTGISNLLAALDLDKVK
                     LIALFSSAAGFYGNTGQSDYAMSNDILNKAALQLAQQLPNAKVMSFDWGPWDGGMVNPA
                     LKKMFIDRGVYVIPLKAGAELFASQLLSDTGAQLLVGTDMQGSAPHDDTSNKLQETEGS
                     NLKKPEADLTTDSSGPHALLNALNPSAVNISAVKLQRTLDPKAMIFIEDHCINGNPVLP
                     TVCAIQWMREAAFDVLKQPVKVQSYKLLKGIIFDAVTLENGAPITLELELAPIALTDKA
                     AKDTDECLSGPFSALISFEGRPQYQAILVIDDAVDDAANDYLATNSKATAFDAQSLAGL
                     SAITTASSLYSDGTLFHGPRLQGIESVVKFDDASLVAKVSLPHFALADCGSFVPNLAPK
                     GSQAFAEDLLLQAMLVWARLKYGAASLPSSIGEFISHAPFAFGDTGYLVLEVVKHSGRA
                     LEANIALYHQDGRLSCEMNNAKVTISKNLNGAFLANKVANKSIESVEAKVE"
     aSDomain        2496..3857
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PKS_KS.1"
                     /domain_subtype="Hybrid-KS"
                     /evalue="9.00E-116"
                     /label="pfaA_PKS_KS.1"
                     /locus_tag="pfaA"
                     /protein_end="482"
                     /protein_start="28"
                     /score="379.0"
                     /tool="antismash"
                     /translation="VAIVGMASIFANSRYLNKFWDLISEKIDAITDIPDTHWRAEDYYD
                     ADKSKADKSYCKRGGFLPEVDFNPMEFGLPPNILELTDTSQLLSLIVAKEVLADANLPT
                     DYDRDRIGITLGVGGGQKISQSLNSRLQYPVLKKVFKSSGLSDEDSEMLIKKFQDQYIH
                     WEENSFPGSLGNVIAGRIANRFDFGGMNCVVDAACAGSLAAMRMALTELTEGRSDMMIT
                     GGVCTDNSPSMYMSFSKTPAFTTNETIQPFDIDSKGMMIGEGIGMVALKRLEDAERDGD
                     RIYAVIKGVGASSDGKFKSIYAPRPEGQAKALERAYDDAGFAPHSIGLVEAHGTGTAAG
                     DVAEFNGLKSVFAQGNDTNQHIALGSVKSQVGHTKSTAGTAGVIKAALALHHKVLPATI
                     NVSQPNPKLNIESSPFYLNTETRPWFQRADATPRRAGVSSFGFGGTNFHLVLEEY"
     aSModule        2496..6431
                     /complete
                     /domains="nrpspksdomains_pfaA_PKS_KS.1"
                     /domains="nrpspksdomains_pfaA_PKS_AT.1"
                     /domains="nrpspksdomains_pfaA_PP-binding.1"
                     /locus_tags="pfaA"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       3483..3527
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pfaA_0001"
                     /evalue="5.90E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="pfaA"
                     /protein_end="372"
                     /protein_start="357"
                     /score="9.5"
                     /tool="antismash"
                     /translation="VEAHGTGTAAGDVAE"
     aSDomain        4233..5186
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PKS_AT.1"
                     /evalue="2.20E-62"
                     /label="pfaA_PKS_AT.1"
                     /locus_tag="pfaA"
                     /protein_end="925"
                     /protein_start="607"
                     /score="202.9"
                     /tool="antismash"
                     /translation="LFAGQGSQYLNMGRELACHFPEMRQQVMASDKAFAHHGQTPLSNI
                     LYPIPAFDADAVKAQEAALTNTLFAQSAIGAISMAQYSLLTQAGFAPDMVAGHSFGELS
                     ALCAAGVISNEDYVELAFARGHAMAQVPSDTASKAADTGTQTDLGTMFAIILKQKNDID
                     ALNSCLAQFDGVKIANYNAPTQLVIAGGTEQTQLAAKAISELGFKAIALPVSGAFHTPL
                     VGHAQKPFAKAIDKAKFSAPSVALYANGTGQLHPTDGKAIKAEFKQHMLQSVRFSEQLQ
                     AMYDAGARVFVEFGPKNILQKLVENTLGEHLNELCLV"
     CDS_motif       4236..4280
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pfaA_0002"
                     /evalue="1.20E-04"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="pfaA"
                     /protein_end="623"
                     /protein_start="608"
                     /score="14.9"
                     /tool="antismash"
                     /translation="FAGQGSQYLNMGREL"
     CDS_motif       4497..4616
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pfaA_0003"
                     /evalue="2.50E-14"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="pfaA"
                     /protein_end="735"
                     /protein_start="695"
                     /score="45.3"
                     /tool="antismash"
                     /translation="GFAPDMVAGHSFGELSALCAAGVISNEDYVELAFARGHAM"
     aSDomain        6228..6431
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PP-binding.1"
                     /evalue="1.00E-12"
                     /label="pfaA_PP-binding.1"
                     /locus_tag="pfaA"
                     /protein_end="1340"
                     /protein_start="1272"
                     /score="40.3"
                     /tool="antismash"
                     /translation="MMAVVADKTGYPTEMLELGMDMEADLGIDSIKRVEILGTVQDELP
                     GLPELSPEDLAECRTLGEIVDYM"
     aSDomain        6531..6734
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PP-binding.2"
                     /evalue="1.00E-12"
                     /label="pfaA_PP-binding.2"
                     /locus_tag="pfaA"
                     /protein_end="1441"
                     /protein_start="1373"
                     /score="40.3"
                     /tool="antismash"
                     /translation="MMAVVADKTGYPTEMLELGMDMEADLGIDSIKRVEILGTVQDELP
                     GLPELSPEDLAECRTLGEIVDYM"
     aSDomain        6852..7052
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PP-binding.3"
                     /evalue="1.80E-12"
                     /label="pfaA_PP-binding.3"
                     /locus_tag="pfaA"
                     /protein_end="1547"
                     /protein_start="1480"
                     /score="39.5"
                     /tool="antismash"
                     /translation="MMAVVADKTGYPTEMLELGMDMEADLGIDSIKRVEILGTVQDELP
                     GLPELSPEDLAECRTLGEIVNY"
     aSDomain        7158..7361
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PP-binding.4"
                     /evalue="4.40E-13"
                     /label="pfaA_PP-binding.4"
                     /locus_tag="pfaA"
                     /protein_end="1650"
                     /protein_start="1582"
                     /score="41.5"
                     /tool="antismash"
                     /translation="MMAVVADKTGYPTEMLELSMDMEADLGIDSIKRVEILGTVQDELP
                     GLPELNPEDLAECRTLGEIVDYM"
     aSDomain        7479..7679
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PP-binding.5"
                     /evalue="1.70E-12"
                     /label="pfaA_PP-binding.5"
                     /locus_tag="pfaA"
                     /protein_end="1756"
                     /protein_start="1689"
                     /score="39.6"
                     /tool="antismash"
                     /translation="MMAVVADKTGYPTEMLELSMDMEADLGIDSIKRVEILGTVQDELP
                     GLPELNPDDLAECRTLGEIVSY"
     aSDomain        8589..9251
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaA_PKS_KR.1"
                     /evalue="5.50E-47"
                     /label="pfaA_PKS_KR.1"
                     /locus_tag="pfaA"
                     /protein_end="2280"
                     /protein_start="2059"
                     /score="151.9"
                     /tool="antismash"
                     /translation="ILVTGGAKGVTFECALSLAKRSKAHFILAGRSSQQAIPAWAQGKN
                     NSELKAAAIAHIQSLGEKPTPKQVDALVWPVQSSQEIAAALQAFTAVGASAEYLSLDVN
                     NPDAIASTIVPITELSPITGIIHGAGVLADKHIQDKTLDELARVYGTKVTGISNLLAAL
                     DLDKVKLIALFSSAAGFYGNTGQSDYAMSNDILNKAALQLAQQLPNAKVMSFDWGPWD"
     CDS_motif       8592..8684
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pfaA_0004"
                     /evalue="9.70E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="pfaA"
                     /protein_end="2091"
                     /protein_start="2060"
                     /score="18.3"
                     /tool="antismash"
                     /translation="LVTGGAKGVTFECALSLAKRSKAHFILAGRS"
     CDS_motif       9105..9179
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pfaA_0005"
                     /evalue="3.30E-08"
                     /label="PKSI-KR_m4"
                     /locus_tag="pfaA"
                     /protein_end="2256"
                     /protein_start="2231"
                     /score="26.1"
                     /tool="antismash"
                     /translation="LFSSAAGFYGNTGQSDYAMSNDILN"
     CDS_motif       9585..9662
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pfaA_0006"
                     /evalue="2.00E-03"
                     /label="PKSI-DH_m2"
                     /locus_tag="pfaA"
                     /protein_end="2417"
                     /protein_start="2391"
                     /score="10.8"
                     /tool="antismash"
                     /translation="FIEDHCINGNPVLPTVCAIQWMREAA"
     gene            10592..12754
                     /gene="pfaB"
     CDS             10592..12754
                     /NRPS_PKS="Domain: PKS_AT (344-661). E-value: 5.5e-19.
                     Score: 60.4. Matches aSDomain:
                     nrpspksdomains_pfaB_PKS_AT.1"
                     /codon_start=1
                     /gene="pfaB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_kind="biosynthetic-additional"
                     /note="EPA synthase"
                     /product="PfaB"
                     /protein_id="ACI12949.1"
                     /sec_met_domain="PKS_AT (E-value: 6e-20, bitscore: 60.4,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLGDAVNLDSHSAQVLGTFAERERVQICAADANQLTVHGPIAHE
                     PKVYEQRSLTALLGQATTAIEQGKLVELKFEDGNLPQYLYLLDGLRAAKLRLHAHAFIA
                     GFAAGNGTTGVANAAAIANAALAAAKRSPAQTVQHQTVANTLNEAFVALRQGVTALATR
                     TQAPLKGTTDIKQTNNTNHQAGYWFSDQHQARVLCLNLVAKTSHQADESRNLSQSLVLT
                     QGTQLAAPKALVDENRLFVPISGDSINELKAKLFQLLSSPDIGAPEWSFASHQLAFWFE
                     RYNTNAPLALVLMAASSDDLKLEAKAMLTALENDAIRHHGQPFKTPAGSCFTAKPLEDA
                     GLTFVYPGVGTVYANMFNNLHEYFPALYHQLEREGDLSAMLQSPQIYAADVKTAAGMSL
                     SQQAISGVGASYLFTKLLTQVFNIKPKMALGYSMGEAAMWASLDVWQTPHGMINATENS
                     DIFNHAISGELTAVRRAWQLADDEAIVWNSFVVRADSNEIKALLPEFPRAYLAITQGDT
                     CVIAGCETSCKALLASLGKRGIAANRVTAMHTAPAMLVHGQVQDFYTQALKPEALKPKA
                     LKAAAQDSSIRFISAAQTAPVIVDSHSIGRAIADTFCSPLDFSALIQNATEQGARLFVE
                     VGADRQTSTLIDKISHAHASQSTANAATAAIACNAKGADAITSLLKCLAQLISHRVPLS
                     LAPLIQPLSANAAPLSSAVSPEGEPQ"
     aSDomain        11624..12574
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaB_PKS_AT.1"
                     /evalue="5.50E-19"
                     /label="pfaB_PKS_AT.1"
                     /locus_tag="pfaB"
                     /protein_end="661"
                     /protein_start="344"
                     /score="60.4"
                     /tool="antismash"
                     /translation="VYPGVGTVYANMFNNLHEYFPALYHQLEREGDLSAMLQSPQIYAA
                     DVKTAAGMSLSQQAISGVGASYLFTKLLTQVFNIKPKMALGYSMGEAAMWASLDVWQTP
                     HGMINATENSDIFNHAISGELTAVRRAWQLADDEAIVWNSFVVRADSNEIKALLPEFPR
                     AYLAITQGDTCVIAGCETSCKALLASLGKRGIAANRVTAMHTAPAMLVHGQVQDFYTQA
                     LKPEALKPKALKAAAQDSSIRFISAAQTAPVIVDSHSIGRAIADTFCSPLDFSALIQNA
                     TEQGARLFVEVGADRQTSTLIDKISHAHASQSTANA"
     gene            12751..18732
                     /gene="pfaC"
     CDS             12751..18732
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (28-488). E-value:
                     6.9e-96. Score: 313.5. Matches aSDomain:
                     nrpspksdomains_pfaC_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (511-913). E-value:
                     2.1e-16. Score: 51.7. Matches aSDomain:
                     nrpspksdomains_pfaC_PKS_KS.2"
                     /codon_start=1
                     /gene="pfaC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hglE-KS: hglE"
                     /gene_functions="biosynthetic (rule-based-clusters) PUFA:
                     PUFA_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 28; E-value:
                     1.8e-08)"
                     /gene_kind="biosynthetic"
                     /note="EPA synthase"
                     /product="PfaC"
                     /protein_id="ACI12950.1"
                     /sec_met_domain="hglE (E-value: 1.1e-20, bitscore: 62.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="PUFA_KS (E-value: 2.6e-205, bitscore:
                     670.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSQHSPTIDKTTVPTIASNRASKSASKIAIVGLATQYPDADNPQ
                     TFWQNLLDKKDSRTQISREKLNANPADYQGVQGQSDRFYCDKGGYIQHFQFDAKGYQLP
                     ESAFDGLDESFLWALDCSRKALKDAGIAPSDAVLARTGIVMGTLSFPTARSNELFLPLY
                     HQTVEKALQNKLNQSAFQLADFNQAHADKALNVEQVLNVANGAVAHTASKLVSDALGLG
                     GTQLSLDAACASSVYALKLACDYLTTGKADMMLAGAVSGADPFFINMGFSIFHAYPDHG
                     ISAPFDSNSKGLFAGEGAGVLVLKRLEDAERDGDNIYAVVSGIGLSNDGKGQFVLSPNS
                     KGQVQAFERAYSAANTQPANIEVIECHATGTPLGDKVELASMERFFEDKLAGSAVPLIG
                     SAKSNLGHLLTAAGMPGIMKMIFAMRAGRLPPSINLSAPISSPKGLFSEKNLPTELHAW
                     PDKAGNSRRHAGVSVFGFGGCNAHLLLESYAANTNKKNEQPAAAVSYQHTPLNIIGLAS
                     HFGPLSSINALDNTISAKQDAFIPLPAKRWKGLDKHPDILANFGLTGTGLAAAPQGAYI
                     DQFDFDFLRFKVPPNEDDRLISQQLLLIKVADEAIRDANLKPGGKVAVLVAMETELELH
                     QFRGRVNLHTQLADSLKKQGITLTQAEYLALEKIAMDSVLDAAKLNQYTSFIGNIMASR
                     IASLWDFNGPAFTISAAEQSVARCIDVAENLLSQESLDAVVIAAVDLSGSLEQVILKNA
                     VSPVAFNATDTGWKVGEGAGALVLTTTQSSAAQPGTAADNTNSNSYGDCYGHISGQVFG
                     AMCDMQGNSNTARICDDLLTQAKVNSSQISLIETSIAVEQRADSELVLNTLLPSVSERS
                     QAANTIGHNFAAAGMASILSALLQLKNHGQLKNHGQLKNQAQPQANQVQHALVATFSQG
                     KCSQLLLSQSATQAHSLQQRLEQDLTLSEQKHLIKQVTLGGRDIYQHILDTPLADIDAI
                     QQKAQAITALPKRSQRKHLAQIASKDTSGFATSSPTTALQKETLSSMPMNALSTPNDNA
                     AQTELKDAAFIRNQQLAREAHLAFLQSRALGLKLADALMKAQLASELAVNGQAAPVQQQ
                     AIVQASATAVLPHPALYPNHAKVPLYTPPTPINKPCIWDYADLVEYAEGDIANVFGQDY
                     AIIDSYSRRVRLPTTDYLLVSRVTKLNAQMNQYQPCTMTTEYDIPVDAPYLVDGQIPWA
                     VAVESGQCDLMLISYLGIDFENKGERVYRLLDCTLTFLGDLPRGGDTLRYDISINHFAR
                     NGDTLLFFFSYECFVGDKLILKMDGGCAGFFTDKELADGKGVIHTEAEIKARNLALNNP
                     NKPRFNPLLDCAQNQFDYSQIHKLLGADIGGCFGGAHAAHQAQYGLQPSLCFASEKFLM
                     IEQVSNLEVHGGAWGLGSVQGHKQLEADHWYFPCHFKGDQVMAGSLMAEGCGQLLQFFM
                     LHIGMHLGVKDGRFQPLENASQKVRCRGQVLPQSGLLTYRMEITEIGMSPRPYAKANID
                     ILLNGKVVVDFQNLGVMIKEEAECTRYLADNDASTAAKNAASAATLVSKTPASFAAPLM
                     AQLPDLTAPTNKGVVPLKHVPAPIAPADSKYANRVPDTLPFTPYHMFEFATGDIENCFG
                     PDFSIYRGLIPPRTPCGDLQLTTRVIAIDGKRGELKKPSSCIAEYEVPATAWYYDKNSH
                     HAVMPYSVLMEISLQPNGFISGYMGTTLGFPGQELFFRNLDGSGKLLRHVDLRGKTIVN
                     DSRLLSTVIAGSNIIQNFSFELSCDGEPFYQGKAVFGYFKGDALKNQLGIDNGKITQPW
                     HVQNDIAADSQINLLDKQHRSFNAPEGQPHYRLAGGQLNFIDKAEIVTAGGKAGLGYLY
                     AERTIDPSDWFFQFHFHQDPVMPGSLGVEAIIELMQTYAIDQDLGAGFKSPKFGQILSD
                     IKWKYRGQINPLNKQMSLDVHITSVTDDNGKRIIMGDANLSKDGLRIYEVKDIAICIEE
                     A"
     aSDomain        12835..14214
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaC_PKS_KS.1"
                     /domain_subtype="Hybrid-KS"
                     /evalue="6.90E-96"
                     /label="pfaC_PKS_KS.1"
                     /locus_tag="pfaC"
                     /protein_end="488"
                     /protein_start="28"
                     /score="313.5"
                     /tool="antismash"
                     /translation="IAIVGLATQYPDADNPQTFWQNLLDKKDSRTQISREKLNANPADY
                     QGVQGQSDRFYCDKGGYIQHFQFDAKGYQLPESAFDGLDESFLWALDCSRKALKDAGIA
                     PSDAVLARTGIVMGTLSFPTARSNELFLPLYHQTVEKALQNKLNQSAFQLADFNQAHAD
                     KALNVEQVLNVANGAVAHTASKLVSDALGLGGTQLSLDAACASSVYALKLACDYLTTGK
                     ADMMLAGAVSGADPFFINMGFSIFHAYPDHGISAPFDSNSKGLFAGEGAGVLVLKRLED
                     AERDGDNIYAVVSGIGLSNDGKGQFVLSPNSKGQVQAFERAYSAANTQPANIEVIECHA
                     TGTPLGDKVELASMERFFEDKLAGSAVPLIGSAKSNLGHLLTAAGMPGIMKMIFAMRAG
                     RLPPSINLSAPISSPKGLFSEKNLPTELHAWPDKAGNSRRHAGVSVFGFGGCNAHLLLE
                     SY"
     CDS_motif       13840..13884
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pfaC_0001"
                     /evalue="4.40E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="pfaC"
                     /protein_end="378"
                     /protein_start="363"
                     /score="9.8"
                     /tool="antismash"
                     /translation="IECHATGTPLGDKVE"
     aSDomain        14284..15489
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pfaC_PKS_KS.2"
                     /domain_subtype="Trans-AT-KS"
                     /evalue="2.10E-16"
                     /label="pfaC_PKS_KS.2"
                     /locus_tag="pfaC"
                     /protein_end="913"
                     /protein_start="511"
                     /score="51.7"
                     /tool="antismash"
                     /translation="IIGLASHFGPLSSINALDNTISAKQDAFIPLPAKRWKGLDKHPDI
                     LANFGLTGTGLAAAPQGAYIDQFDFDFLRFKVPPNEDDRLISQQLLLIKVADEAIRDAN
                     LKPGGKVAVLVAMETELELHQFRGRVNLHTQLADSLKKQGITLTQAEYLALEKIAMDSV
                     LDAAKLNQYTSFIGNIMASRIASLWDFNGPAFTISAAEQSVARCIDVAENLLSQESLDA
                     VVIAAVDLSGSLEQVILKNAVSPVAFNATDTGWKVGEGAGALVLTTTQSSAAQPGTAAD
                     NTNSNSYGDCYGHISGQVFGAMCDMQGNSNTARICDDLLTQAKVNSSQISLIETSIAVE
                     QRADSELVLNTLLPSVSERSQAANTIGHNFAAAGMASILSALLQLKNHGQLKNHGQLKN
                     QAQ"
     gene            18852..20498
                     /gene="pfaD"
     CDS             18852..20498
                     /codon_start=1
                     /gene="pfaD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 574.3; E-value: 5.2e-174)"
                     /gene_kind="biosynthetic-additional"
                     /note="EPA synthase"
                     /product="PfaD"
                     /protein_id="ACI12951.1"
                     /transl_table=11
                     /translation="MTSHTLDQFNSNNEKLSPWPWQVNDAELSFDIDSLGKKLKDLSQA
                     CYLVNHSEKGLGIAQTAEVTTSDSQAPLGSHPVSAFAPALGTQSLGDSNFRRVHGVKYA
                     YYAGAMANGIASEELVIALGQAGILCSFGAAGLIPSRVEAAITRIQAALPNGPYAFNLI
                     HSPSEPALERGSVELFLKHKVRTVEASAFLGLTPQIVYYRAAGLSRDEHGEIVIGNKVI
                     AKISRTEVATKFMEPAPAKILQQLVSDGLISQDQMAMAQLVPMADDITAEADSGGHTDN
                     RPLVTLLPTILALKDEIQAKYQYKTPIRVGAGGGVGTPDAALATFNMGAAFIVTGSINQ
                     ACVEAGASEHTRKLLATTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYEIYT
                     RYDSIDAIPADERKKLEEQVFRSSLDDIWAGTVAHFNERDPKQIERALDNPKRKMALIF
                     RWYLGLSSRWSNTGEVGREMDYQIWAGPALGAFNAWAKGSYLDDYKARNAVDLAKHLMV
                     GAAYQSRINLLLSQGASIPVTLLRWKPLNRF"
ORIGIN
        1 ttaataatca gcaagtaaga cttctatgct gctcagctgc gcggttagcg ttatgggaag
       61 cgcggcatta ccggcatgcg ctaagctaat ggcaaagcga tactcctcgg tcaaacgacc
      121 aaagtgcgtc tgccaaagca aggagtcagc taaatccagt gtgtgtattg ggatttgtag
      181 cgggattttt agcgagatat gtggataaac attaagcatt gaagctacgc cgcaggcttg
      241 cctcaatccg gcatcttggc atgataactc aagcgattct gccgccaatt gctcaaacgg
      301 cttaagctca aaggcaaagg atttgagcga ctgcgctaaa cctaaaccag tcgccttaat
      361 ataggactcc tttagcgccc ataaatcgaa aaagcgctgc cgctgactcg cttcatcggc
      421 gagggcgagc aaggccacgg tttcttgcgg agaaaaatag tgatttagga ttggatagat
      481 atccgtcttc ggccgtgacc tttcaatatc gaccccaaat aaaacagact caacaccatc
      541 aaactgagcc acaccaatca ataaccaatc gccgctatgg cttaaattaa actcaagccc
      601 cgtttgctgt tgcaatgtcg ccgttaaact cggtttgccc ttagcgccat attcaaaaca
      661 ccactcgtgt ggcgataaat ccgcatagcg agataatacg gcccgcagcg ccgccctcac
      721 ctgtaatccc tttatttgcg ccttgggatc gcgatagcgc ctgacctttg cgagttcatc
      781 atcacttaac caagactcgg caagtgatgt ttgcgccgct gacatatcgt tcagtggaat
      841 aaaaaataga tccacattca cgccgttttt gctagatgtt agagagtcgg tcattcgaga
      901 gcctagctgt acaaagccct gcggctgatg agttatcatt ggctggcttt ttggggagca
      961 cttagcaaca ttcttatctg gttcattatt gtctaggttc ctcattatct gagttcatta
     1021 tgcatcttaa atagtttcaa ctaagcccta tttcaattct tagccgcact ctaataagag
     1081 caattcttag aacgactatt aactctatcc taagcgcaaa tttttgctgc aattgcgcca
     1141 agattccccc aaaaattagc aggtttagcc gcatagcctc attcatgacg aaaaggactt
     1201 aggccaatat tgggctattt taccccgata actcaaaaaa gctgccttca tcgccgctac
     1261 aaataatatt cttccactat caaagtatta aacagtccaa gcagtaagcg aaaacccaac
     1321 ataacgcaca gaaaatacca ttactcaacg aaagctaata aattccagtc ccagatgatt
     1381 gtatcgctcc gaaacctcag gtaatctgca tccccattaa gtgacacaga tgataagcac
     1441 aggttttacg atgagtgtca cgacattagt cataaatgtc agtcgtgact cagccaaaat
     1501 cgcttatcag tcccaataga ttatgtcgga tgataattat ttttaatggc aactcgcgac
     1561 tctcaatcta aagcgccgtc ttacgccccc aagagcacga ctccagcggc gcaaaaagac
     1621 agcacacctc ggcatcgcaa cgccaccact acgcctgaaa tgcgactctt tatccaacaa
     1681 tcggatctga gcgtcagcca actggcaaaa attttaaata ttaccgaggc aacggtgcgt
     1741 aagtggcgta agcgtgagtc catcagcaac agttcgaaca cgccccacca tctcaacacg
     1801 acgctcacgc cgatggaaga atatgtggtg gtgggattac gctaccaact cagactcacc
     1861 ttagatagat tgctccacgt cacccaaacc tacattaatc ccaatgtgtc gcgctccggc
     1921 cttgctcgtt gcttaaagcg ctacggcata tcgcggctcg atgagtttga agcaccacaa
     1981 gtacccgaac gctattttaa tcaattacct gtgactcaag gcagcgatat ccaaacctat
     2041 acggtcaatc cagaaacctt ggccaaggcg ctggctctgc caagtaccga cggtgatact
     2101 gtggtgcaag tggtctcact caccataccg ccgcagctta ctgagcaagc tccaagctca
     2161 gtgctattag gcatagatac ggcaagtgat tggatttacc tcgatattta tcaagacagc
     2221 aatactcaag cgaccaatag atatatcgcc tatgtcctcc gacatgggcc gtttcattta
     2281 cgaaagttgc tcgttcgcaa ctatcacacc ttcttagccc gttttcccgg tgcccatggc
     2341 acgccaaaga caaacgcggc tgaaccccaa aacaaggtca ccgtatccag gtcgacccgt
     2401 ggagactctt tatgagccat accccttctg tacctaattc tgcgactgag tcaaaaaaag
     2461 ataaacgact caacaaacgt ttgaaagata tgcccgttgc cattgtcggc atggccagca
     2521 tcttcgctaa ctcgcgttat ttaaataaat tttgggattt aatcagcgaa aaaatcgatg
     2581 ccattactga catcccagac acccattggc gcgccgaaga ttattacgat gcagacaaaa
     2641 gcaaagccga taaaagctac tgtaaacgcg gtggtttttt gcctgaagtc gactttaacc
     2701 ccatggaatt tggtctgccg cccaatattc ttgagctgac agatacctcg caactgctgt
     2761 cgctgattgt cgccaaagaa gtgctcgccg atgccaatct gcccaccgat tatgatcgcg
     2821 atcgtatcgg catcacgcta ggcgtaggcg gtggtcaaaa aatcagtcaa agcttaaact
     2881 cgcgcctgca atatccagtg cttaaaaaag tattcaaaag cagcggcctg agcgatgaag
     2941 acagcgaaat gctgatcaaa aagttccaag accaatatat ccactgggaa gaaaactctt
     3001 tcccagggtc cttaggcaac gtgattgcag gccgtatcgc caaccgtttt gattttggcg
     3061 gcatgaactg cgtggtcgat gctgcctgtg cgggctcgct ggccgctatg cgtatggcgc
     3121 tgacagaact gaccgaaggc cgcagcgaca tgatgatcac cggcggcgtc tgtactgaca
     3181 actcgccgtc catgtacatg agcttctcaa aaacgccggc cttcaccact aacgaaacca
     3241 ttcaaccctt tgatatcgat tcaaaaggca tgatgatcgg cgaaggtatt ggcatggtcg
     3301 cgcttaaacg ccttgaagat gccgagcgcg atggtgaccg gatttatgcc gtcatcaaag
     3361 gcgttggcgc ctcatctgac ggtaagttta agagtattta tgcgccgcgc cctgagggcc
     3421 aagctaaagc actcgaacgc gcttacgacg atgcaggttt tgccccgcac agcattggct
     3481 tagttgaagc ccacggcacc ggcacagctg caggtgatgt ggctgaattt aatggcttaa
     3541 aatcggtatt tgcccaaggc aacgacacaa atcagcatat cgcgttaggt tcagtgaaat
     3601 cccaagtggg ccacactaaa tcaacagcgg gtactgccgg ggttatcaaa gccgcgctgg
     3661 cactgcatca caaggtattg cctgcgacca ttaacgtcag ccagcctaat ccaaaactga
     3721 atatcgaaag ttcgccattt tatttaaata ccgaaacgcg cccatggttc caacgcgcag
     3781 atgcaacacc gcgccgtgct ggcgtcagct cctttggttt tggcggcact aacttccatc
     3841 ttgtattaga agaatacaaa cctgagcata gccgtgacga gcaatatcgt cagcgcagtg
     3901 tgccgcagac actattgttt gccgccgcca ataaagccgc gctgcttagc gagttaaaag
     3961 ctgcgctgag ccaaagtgtg aacacgaacg cgaataagag cagcgctgcg agtctgaacg
     4021 ctatcgctca gcaatatccg ctacgcacac tggcaagcac agatgcccgt ttaggttttg
     4081 tggctaagga tatcgcacag ctgcaagctc agttaaatca atcgattgcg catttagaaa
     4141 ccaatgcaat tgaagtgtgg caattacctt ctggtatcag ctaccgctct catgccttag
     4201 tggctaagaa tgaatcaaag aaagtagccg ccctgtttgc cggtcaaggt tcacagtacc
     4261 tgaacatggg ccgcgaactc gcctgccatt tccctgaaat gcgccaacaa gtgatggcca
     4321 gcgataaagc atttgctcac cacggccaaa caccgttatc caacatcctt taccctattc
     4381 cggcattcga tgccgatgcg gtgaaagccc aagaagcggc gctaaccaat accctgttcg
     4441 cccaaagcgc cattggcgca atttcaatgg cgcaatattc gctattaact caagcgggtt
     4501 ttgcccccga tatggtggca ggtcacagct ttggtgaact gtcagccctt tgcgcggcag
     4561 gcgtgatttc caatgaagat tacgtcgaac tggccttcgc ccgcggacat gccatggcgc
     4621 aagtgccgag cgataccgcg agtaaagccg cagacactgg gactcaaact gacttaggga
     4681 caatgttcgc catcattctt aagcaaaaga atgatatcga tgcgctcaat agctgtttag
     4741 cccagtttga tggcgttaaa attgccaact acaacgcgcc gacacaatta gtcattgcag
     4801 gtggcacaga gcaaactcag ctggccgcta aagccattag cgaactgggc tttaaagcga
     4861 ttgccctgcc cgtctctggc gcgttccata ccccattggt tggacacgca caaaagccat
     4921 ttgctaaagc cattgataaa gctaaattca gcgcaccttc tgtcgcactt tatgccaacg
     4981 gcacgggtca attacaccca accgatggca aagcgattaa agcagaattc aaacaacaca
     5041 tgctgcaatc ggttcgcttt agcgaacaac tgcaggccat gtatgacgct ggcgcccggg
     5101 tatttgttga gtttggtcct aaaaacatac tgcaaaagtt agttgaaaat accttaggtg
     5161 aacacttaaa tgagctttgc cttgtcagca tgaacccgaa tcctaagggc gacagtgaca
     5221 gtcaattacg cttagccgca gtgcaactcg cggtagccgg tgtggcatta actgaagttg
     5281 atccctatca agccattacg tcacaagaga ttgccgaacg tgaagcgcca tcagcaatga
     5341 acatcaaact caccgccact aaccatatta gtgctgcgac caaagctaag atggccaaat
     5401 ccctcgccac aggcagcgtg actagccaag tgcaatatgt ggatcgcatc gttgaaacgg
     5461 ttgtcgaaaa agaagtcgaa aaaatcgttg agaaacaagt catcgtcgaa aaagttgttg
     5521 agaaaataat agaagtggaa gcgaatcaag tggcagctgt tgaaatgaaa caaacatccc
     5581 caagcgttgt gcaaggctta agcaatcacc agcagcaagc gacggcgcag ttaagcccaa
     5641 acacacctaa catcagcagc gatgcgttaa cggcattttt cagcgcacaa tctcacgtgg
     5701 cgcagttaca tcaacagttt ttagccatcc cgcagcaata tggcgatacc ttcacgacgc
     5761 tgatgacaga acaagccaag atggcgagcc aaggcattac aatcccagaa agtctgcaac
     5821 gctcaatgga aatgttccac cagcatcaag cgcaaaccct gcaaagccac gccgaattta
     5881 tgcagctaca aagcagtagc agccaagcgg cattggccat gttaaacaat gcgccgatta
     5941 actttacccc agcggttgca agtcagccac gagtaactgc gccggctcct gcacctgttg
     6001 ctgcatcgac agtggcgcac aatgccgcac cagtagcggc tcaggctgtt gcgacgagac
     6061 cagcagttag cacacccatt cctcctgttg tgcaaacggc tccggttgct tttgcacctg
     6121 cggtgacagt acaagttgcg ccagcagctc ctgttttagt tatgccagag atgacatctg
     6181 tggcaccagc aacaagcagc ttaagtgctg cacttgttca acaaactatg atggctgtgg
     6241 ttgccgacaa aacaggctac cccactgaaa tgctggaact tggcatggat atggaagccg
     6301 atctaggtat cgattcgatt aagcgcgttg aaattttagg cacagtacaa gacgaactgc
     6361 cgggcttacc tgaactcagc ccagaagatc tggccgagtg ccgtacctta ggtgaaatcg
     6421 ttgactatat gaactctaaa ctgcctgcgg ctggccaagt tgtagtttct acaacagcgc
     6481 caacagctcc tgccgccaac ggtttaagcg ctgcgttagt gcaacaaacc atgatggctg
     6541 tggtggctga caagacaggc tatccgactg aaatgctaga acttggcatg gatatggaag
     6601 ccgatctagg tatcgattcc ataaagcgcg ttgaaatctt aggcacagta caagacgaac
     6661 tgccgggttt accagaactc agcccagaag atctggccga gtgtcgcacc ttaggtgaaa
     6721 tcgttgacta catgaacagc aaattgccag tagttagcgt ggtagcagtt gcaccaccgg
     6781 caaacgttga agcaacgcct gcacaaattc cagcgaataa cggtttaagc gctgccttag
     6841 tgcaacaaac catgatggct gtggtggctg acaagactgg ctatccgact gaaatgctgg
     6901 aacttggcat ggatatggaa gccgatctag gtatcgattc aattaagcgc gttgaaatct
     6961 taggcacagt gcaagacgag ctgccgggtt tacctgagct cagcccagaa gatttggccg
     7021 agtgtcgcac cttgggtgaa atcgttaatt acatgaacag caaactgcca gctgtgggat
     7081 cagttatcgt agcaactcat gtgacagctg ccgcgcctgc cgccagcggt ttaagcgctg
     7141 cgttagtgca acaaaccatg atggcagtgg tggccgacaa aacaggctat cccactgaaa
     7201 tgctggaact cagcatggat atggaagccg atctaggtat cgattctatc aagcgcgttg
     7261 aaatcttagg tacagtgcaa gatgagctac cgggcttacc tgagctgaat cctgaagatc
     7321 tggccgagtg tcgcacctta ggcgaaatcg ttgactacat gaacagcaaa ttgccagtaa
     7381 ttagcgcggt agcagttgca ccagcggcaa acgttgaagc aacgccagca caagttccag
     7441 cgaataacgg tttaagcgct gaaaaagtcc aacaaaccat gatggctgtg gtggccgaca
     7501 agacgggcta ccccactgaa atgctggaac tcagcatgga tatggaagcc gatttaggta
     7561 ttgattcgat caagcgcgtt gaaatcttag gcacagtaca agacgagcta ccaggcttac
     7621 ctgagctgaa tcctgacgat ctggccgagt gtcgcacctt aggtgaaatc gttagttata
     7681 tgcaaggtaa gctaggccag aatgtagcgc caattagcgc tgtcgcggct gaaccagcta
     7741 tcgatttgcc accccatgat ttaccacccc atagcgaggt agtgctaaaa aagttgccag
     7801 cggcggctga gctaacgcag caatcagcac aaaaagctct gccacgtgtt tttgctaaag
     7861 atgcctgcat tatcattagc gatgatggtc acaatgctgg cgtacttgcc gagaaattgc
     7921 atgctcaagg tctaacggtt gcggttgtgc gctcgccaga aagccttgta gccagtgcat
     7981 caccgctcaa tagccacatt gccagcttca cattggcggc gattgacgat gccagtatca
     8041 gcgcagtgat taatgagatc aaaagcttag gtcaggttgc aggctttatt catctgcaac
     8101 cacaacataa aacctcagcc gatgcgaaag gtttagtgtt atcgagtgcc gccaaagcgt
     8161 cggtcgagca agcgttcttg ttcgccaaac acttacaacc gcttttaaca acagcagcaa
     8221 cggcaaatac tgatagcagc tttatcagcg tcagtcgtat cgacggtggt tttggttatc
     8281 ttaaccacag ccaaattgcc cgcagcgagt taaaccaagc ggcattggca ggtctgacta
     8341 aaaccttgag ccacgagtgg ccaagcgtgc attgccgcgc cttagatatc gcgccagcac
     8401 ttgatgccaa gcaactggcc aatgcggtca tcgctgagtt atttgcaacc gataagctat
     8461 tagaagtcgg tgtgagtgaa agtagtgtga gtgaagctgg cgcaacagaa acactggcac
     8521 gcgtgacctt agttgcaggc aaggcagata cccgccacgg cgcagctaac ttaacgagtg
     8581 ctgataaaat tctggtgact ggcggcgcaa aaggcgtgac ctttgaatgt gccttgagtc
     8641 tggcaaaacg cagcaaggcg cactttatcc ttgccggcag aagcagccaa caagccattc
     8701 ctgcttgggc acagggtaag aataacagtg aacttaaagc cgcagctatt gcccatattc
     8761 aaagcttggg cgagaaaccc accccaaaac aagtggatgc cttagtatgg ccagttcaaa
     8821 gcagccaaga aattgcagca gcactgcaag cctttaccgc agtaggcgcg agtgccgagt
     8881 acttaagcct cgatgttaac aatccagacg cgatcgccag cactatagtg ccgatcaccg
     8941 agttatcacc tattaccggc atcatccatg gtgcgggcgt actcgccgat aaacacatcc
     9001 aagacaaaac cttagatgag ttagcacggg tgtatggcac taaggtcaca ggcattagca
     9061 atctgcttgc cgcactggat ttagataaag taaaactgat tgccctgttc tcttcggcgg
     9121 cgggttttta cggcaatacc ggccaaagcg attacgccat gtccaacgac atactcaaca
     9181 aagccgcact gcaactggcg cagcaactgc caaatgctaa agtaatgagc ttcgattggg
     9241 gtccgtggga cggcggcatg gtgaatcctg cgctgaaaaa gatgtttatc gatcgcggtg
     9301 tttatgtgat cccgttaaag gcgggtgctg agttatttgc gagccaatta ctgagcgaca
     9361 caggcgcaca attgctggtc ggtactgaca tgcaaggcag cgcacctcat gacgacactt
     9421 ctaataaatt gcaagagact gaaggtagca atctaaaaaa gcctgaagcg gatctgacca
     9481 ctgactcgtc gggtccgcat gctttgctta acgctttaaa tccaagcgca gtaaatataa
     9541 gcgctgtaaa actgcagcgc acactggacc ctaaggcaat gatctttatt gaagatcact
     9601 gcattaacgg taatcccgta ttaccgactg tgtgcgcgat tcagtggatg cgtgaagccg
     9661 cctttgatgt gctcaagcag cctgtcaaag tgcaaagcta caagctgttg aagggcatta
     9721 ttttcgacgc tgtgacgtta gaaaacggtg cgcccatcac gctagaactt gagcttgcac
     9781 cgattgcgtt aacggataaa gccgcgaaag acacagacga gtgcttgagt ggaccattca
     9841 gtgccttaat cagctttgaa ggtcgtccgc aatatcaagc catcttagtg attgatgatg
     9901 ctgttgatga cgcggctaac gattacttag ccactaacag caaagcaacc gcctttgacg
     9961 cgcaaagctt ggcaggactt tctgccatca caaccgcgag cagcctttac agcgacggca
    10021 cgcttttcca cggcccaaga ctgcaaggta ttgagtctgt ggtgaagttt gacgatgcga
    10081 gcttagtcgc caaggtgagt cttccccatt ttgcgttagc ggactgcggg agttttgtgc
    10141 ccaatctggc ccctaaaggc tcacaagctt ttgcagaaga tttgttgctg caggcgatgc
    10201 tggtatgggc aagactcaaa tatggcgcgg cgagtttgcc atcaagcatt ggtgagttta
    10261 tctcccatgc gccgtttgcc tttggcgata cagggtatct agtgctcgag gtggtaaaac
    10321 actctggccg tgcccttgaa gccaatattg cactttatca tcaagatggc cgcttgagct
    10381 gcgagatgaa caacgccaaa gtcaccatca gcaaaaacct taacggtgca ttcttagcta
    10441 ataaagttgc taataaaagc attgaaagcg tggaggcaaa agtcgagtga acttagcccc
    10501 ccctttagca acgacccata acggccaagc tgaaacgtcg atagctgaca agactattgc
    10561 agaaaaaagc gccaagccac tgcgtattgc agtgttgctt ggcgatgccg tcaaccttga
    10621 ctctcactca gcccaagtat tagggacgtt tgcagaacgt gaaagagttc agatttgcgc
    10681 tgccgatgcc aaccaattaa cagtacatgg gccgatagct catgaaccaa aagtgtatga
    10741 gcaaaggtcg ctcactgcct tgttaggcca agcaacaaca gccattgagc aaggcaagct
    10801 cgttgaactt aaatttgagg atggtaatct accccagtat ctgtatttgc ttgatggttt
    10861 acgcgccgcc aaactgcgtc ttcacgccca cgcgtttatt gctggctttg ccgctggcaa
    10921 tggcactaca ggtgttgcaa atgcggcggc tattgcaaat gcagcgttag cggcggcaaa
    10981 gcgcagccca gctcaaaccg ttcaacatca gactgtcgcc aacacactca acgaggcatt
    11041 tgttgcgctg cgccaaggcg taaccgccct cgccacgcga acacaagcgc cgcttaaagg
    11101 cactactgat ataaaacaga caaacaacac caatcatcaa gctggctatt ggtttagcga
    11161 ccaacatcaa gcgcgggtgt tgtgtctaaa tcttgtagca aagacgtcac atcaagcgga
    11221 tgagtctcga aatctaagcc aaagcctagt gctgacccaa ggcacacaac tcgccgcgcc
    11281 caaagccctt gttgatgaaa accggctgtt tgtgccgata agtggtgaca gtattaatga
    11341 gttaaaagca aaactgtttc agttgcttag ttcaccagac attggcgcac cagaatggtc
    11401 atttgcatca catcaactcg cattctggtt tgaacgctat aataccaacg cgcctctggc
    11461 gttagtcttg atggcggcat caagtgatga tctcaaactt gaagctaagg ccatgcttac
    11521 ggcgcttgaa aatgatgcta ttcgtcatca cggtcaaccc tttaagacac cagcgggcag
    11581 ttgctttacc gctaagccgc tagaggatgc gggacttacc tttgtatatc ccggcgttgg
    11641 cactgtttat gccaatatgt tcaacaactt gcatgagtat ttccccgcgc tgtatcacca
    11701 gctagaacgt gaaggcgatt taagcgccat gctgcaatca ccgcagattt atgcggcaga
    11761 tgttaaaacc gcagctggca tgagcttaag ccaacaagcg attagtggcg tgggggccag
    11821 ttatctattc actaaactgt tgacccaagt ctttaatatt aaacctaaaa tggcgctcgg
    11881 ttactctatg ggcgaagcgg ccatgtgggc cagcctagat gtgtggcaaa caccgcacgg
    11941 gatgattaac gccactgaaa atagcgatat tttcaaccat gcgatttctg gtgagctaac
    12001 cgcagtccgc cgagcgtggc agcttgcgga tgatgaagcc atagtgtgga acagctttgt
    12061 ggtgcgcgct gatagcaatg aaatcaaggc attattgcca gagtttcctc gcgcctactt
    12121 agccatcacc caaggtgata cttgcgtcat tgcaggctgc gaaacaagct gcaaagccct
    12181 gcttgcctcg ttaggcaagc gcgggattgc cgccaatcgc gtcacggcaa tgcataccgc
    12241 gccagccatg ttagtccatg ggcaagtaca agacttctat actcaagcgc taaaacccga
    12301 ggcactgaaa cctaaggcgc tgaaagcggc ggcgcaagat tcgtctattc gctttattag
    12361 cgcagcgcaa actgcgccag taatcgtgga tagccacagc attggccgcg cgattgccga
    12421 taccttttgt tcgccactcg actttagtgc gctcattcaa aatgccactg agcaaggcgc
    12481 aaggctgttt gtcgaagtgg gcgccgatag gcaaaccagc acactcatag ataaaattag
    12541 ccacgcccac gcaagccaaa gcactgcgaa cgcggcgaca gccgccattg cttgcaatgc
    12601 caaaggtgct gacgcgatca ccagcttact caagtgttta gctcagctaa taagccacag
    12661 agtgccgctt tcgctcgcgc cgctcattca gccattaagt gctaacgcag cccctttatc
    12721 atcagcagta tcaccagaag gagaacccca gtgagttctc agcattcccc tactattgat
    12781 aaaactaccg tgcctaccat tgcgtcaaac cgcgcatcaa aaagtgcgtc aaaaattgcg
    12841 attgtcggtc tcgcgactca gtatcctgac gccgataatc cacaaacctt ctggcaaaat
    12901 ctgttggata aaaaagactc acgcacccaa attagccgcg aaaagctcaa tgctaatccc
    12961 gccgattacc aaggtgtgca gggtcagtct gaccgttttt actgtgataa aggcggctac
    13021 atccaacact tccagtttga tgccaaaggt tatcaactgc ctgagtctgc ctttgacggt
    13081 ttagatgaaa gctttttatg ggcactcgat tgcagtcgta aagccctcaa agacgcaggg
    13141 attgctccaa gcgatgccgt actggcgcgc acaggtatcg tgatgggaac cttgtcgttc
    13201 ccgaccgccc gctccaatga attatttttg cctctgtatc atcaaaccgt tgaaaaggcg
    13261 ctgcaaaaca aacttaatca aagcgctttt cagttggctg attttaacca agctcacgcc
    13321 gacaaagcgt taaacgtcga gcaagtatta aacgtcgcca atggcgccgt tgcccacaca
    13381 gcttcaaagc tagtcagcga tgcactcggt ttaggtggta ctcagttaag tctggacgcc
    13441 gcctgcgcta gctcggttta tgcactcaaa cttgcctgcg attacctaac cacaggcaag
    13501 gccgatatga tgcttgcagg cgcagtatcg ggcgcagatc ctttctttat caacatggga
    13561 ttctcgattt ttcacgccta cccagatcac ggtatatcgg cgccctttga tagcaacagc
    13621 aagggcttat tcgccggaga aggcgcaggg gtgttagtct taaaacgctt agaagatgcc
    13681 gagcgtgatg gcgataatat ctatgccgtc gtcagcggca ttggtttatc gaacgacggt
    13741 aaaggccagt ttgtattaag ccccaacagc aagggccaag tgcaagcctt cgagcgcgcc
    13801 tatagcgcgg caaacactca gcctgccaat atcgaagtga ttgaatgcca tgccacaggc
    13861 acgccgctcg gggataaggt cgagctcgcc tcgatggagc gcttcttcga ggacaaactc
    13921 gcgggctctg cagtgccgct gatcggttca gcaaaatcca acttaggcca tttactcacc
    13981 gccgcaggaa tgccggggat catgaagatg atttttgcca tgcgcgcggg tcgactgccg
    14041 ccaagtatta acttatcagc gccgatatcc tcgcctaagg gcttgtttag cgaaaaaaat
    14101 ctgccaacag aattacatgc ttggcccgat aaagccggaa actcccgccg ccacgccggt
    14161 gtttccgtgt ttggttttgg cggctgtaat gcgcatttgt tgctggaatc ctatgctgcc
    14221 aatacaaaca aaaagaatga acaacctgca gccgctgtaa gttatcagca cacgccatta
    14281 aatatcattg gtttagcgtc gcactttggg cctttatcct ccattaatgc actggataac
    14341 acgataagcg caaagcaaga tgccttcatc ccgctgcccg ctaagcgctg gaaaggctta
    14401 gataaacacc ctgatattct agccaacttt ggtttaaccg gaactggcct cgcagccgca
    14461 ccacagggcg cgtatatcga ccagttcgat tttgactttc tgcgctttaa agtgccgccc
    14521 aatgaagacg accgcctgat ctcccagcaa ctgctgctga taaaagtggc cgatgaagcg
    14581 attcgtgatg cgaacttaaa gcccggtggc aaggttgcag tattagtggc gatggaaacc
    14641 gaactggaat tacaccagtt ccgtggccgc gtaaatctac acacacaact ggccgacagc
    14701 cttaaaaaac aaggaataac actcacacaa gctgagtatc tcgcccttga aaaaatcgcc
    14761 atggacagtg tgctcgatgc cgccaaactg aatcaataca ccagttttat tggcaacatc
    14821 atggcgtcac gtatcgcatc cctttgggac tttaacggcc cagcctttac catttcggcg
    14881 gcagagcaat cggtcgcccg ctgtatcgat gtggccgaaa acctcttgtc ccaagaatcc
    14941 ttagatgccg tagtgatcgc cgccgtcgat ttaagtggca gccttgagca agtgatcctc
    15001 aaaaacgccg tatcgccagt ggcatttaat gccactgaca ctggttggaa agtcggtgaa
    15061 ggtgcaggcg cattagtgct cacgacaaca caatcaagtg cagcccagcc aggcactgcc
    15121 gctgacaata ccaatagcaa cagctatggc gactgttatg gtcacatcag cggccaagtg
    15181 tttggtgcta tgtgtgacat gcaaggtaac agcaacacag cgcgcatttg cgatgacttg
    15241 ttaacccaag ccaaggtgaa tagcagccag attagcttga ttgaaaccag tattgctgtt
    15301 gagcaacgtg ccgattcaga gttggtactc aacaccctgc tgccgagtgt gagtgagcgc
    15361 agccaagccg ctaatactat tggtcacaac tttgctgctg cgggcatggc gagtattttg
    15421 agcgccctgc ttcagcttaa aaatcatggg caacttaaaa atcacgggca attaaaaaac
    15481 caagcacagc cacaagctaa tcaagtgcag cacgcgctcg ttgccacgtt tagccaaggt
    15541 aaatgctcgc agttattgct cagtcaaagt gcgacgcaag cacacagttt gcagcaaagg
    15601 cttgaacaag acttaacgct ttctgagcaa aaacacttaa taaaacaagt gacgcttggt
    15661 ggccgcgata tctatcagca tatccttgat acgccgctcg cggacatcga tgctatacag
    15721 caaaaagccc aagccatcac tgcattgcca aagcgcagcc aacgcaaaca tttggcccaa
    15781 atagcgagca aagacacgag tggctttgca acaagcagcc caaccacggc actacaaaaa
    15841 gagacattaa gcagcatgcc aatgaatgcc ctaagcacgc ccaatgacaa cgcagctcaa
    15901 acagagctaa aagacgctgc atttatacgt aatcagcaac tcgcccgtga agcacaccta
    15961 gcctttttac aaagccgtgc gctgggcctg aaactggccg atgccttgat gaaagcccag
    16021 cttgccagcg agttagccgt caatggccaa gctgcgccgg tacaacagca agccatcgtt
    16081 caagcatctg cgacagcggt tcttccacat cctgcgcttt atccaaacca tgcaaaagtg
    16141 cctctgtaca cgccgccaac accgataaac aagccttgta tttgggatta tgcggattta
    16201 gtcgagtacg ccgaaggcga tatcgctaac gtctttggcc aagattacgc cattatcgac
    16261 agctattcgc gccgtgtacg cctgccaacg actgactatt tactggtatc tcgagtaacg
    16321 aaattaaacg ctcagatgaa ccaatatcag ccttgcacta tgaccacaga atacgacatt
    16381 cctgtggacg cgccgtattt ggtcgatggt caaattccgt gggccgtggc cgttgaatcg
    16441 ggtcaatgcg acttaatgct gatcagctac ttaggtatcg actttgaaaa caagggcgag
    16501 cgcgtttatc gtctgctcga ttgcaccctg accttccttg gcgacttacc gcgcggtggc
    16561 gacaccctgc gctacgatat ttccatcaat cactttgccc gcaatggcga taccttgttg
    16621 ttcttcttct cctacgaatg tttcgtgggc gacaagctga tcctgaaaat ggatggcggc
    16681 tgtgccggct tcttcaccga caaggaactg gccgacggca aaggcgttat tcacaccgaa
    16741 gccgaaatca aagcgcgcaa cctcgccttg aacaatccga ataagccgcg ctttaatccg
    16801 ttacttgact gcgcgcaaaa ccaatttgat tacagccaaa ttcataaatt gctcggcgcc
    16861 gatatcggtg gctgttttgg cggcgcccat gcggcgcatc aagcccagta tggtttgcag
    16921 ccctctttat gttttgcatc cgaaaaattc ctgatgattg aacaggtcag caatcttgag
    16981 gtgcatggcg gcgcgtgggg cttaggttca gttcaaggcc ataaacagct cgaagccgat
    17041 cattggtatt tcccgtgtca tttcaagggc gaccaagtga tggcggggtc gttaatggcc
    17101 gaaggctgtg gtcaattact gcaattcttt atgctgcata ttggtatgca cctcggtgtt
    17161 aaagatggtc gtttccaacc gctcgaaaac gcatcacaaa aagtgcgctg tcgcggtcaa
    17221 gtgttgccgc aatctggcct gctcacctat cgcatggaaa tcaccgaaat cggtatgagc
    17281 ccgcgcccgt atgctaaggc gaatatcgat attttgctca atggcaaagt ggtcgtggat
    17341 ttccaaaacc ttggggtgat gatcaaagaa gaagccgaat gcacccgcta ccttgcggat
    17401 aatgatgcca gcacagcagc caaaaatgct gcttcggctg caacgctggt ttcaaaaaca
    17461 cctgcatcgt tcgccgcgcc gttgatggcg caactgccag atttaactgc gccaaccaac
    17521 aaaggcgtag tgccgctaaa gcatgtacct gcgccgattg cgccagcgga ttcaaagtac
    17581 gccaaccgcg tgcccgatac cctgccgttc acgccatacc acatgttcga atttgccact
    17641 ggcgatatcg aaaactgctt cggccctgat ttcagcatct atcgcggcct tattccaccg
    17701 cgcacgcctt gcggtgattt acagctcacg actcgtgtca ttgcgattga cggcaaacgc
    17761 ggcgagctga aaaagccctc ttcatgtatc gctgaatacg aagtgcccgc aactgcttgg
    17821 tattatgaca aaaatagtca tcacgccgtg atgccctatt ctgtgctgat ggaaatatca
    17881 ctgcagccaa acggctttat ctcaggctat atgggcacca ccttgggctt ccccggccaa
    17941 gagctatttt tccgtaactt agacggtagc ggtaagctgc tgcgccacgt ggatttacgc
    18001 ggcaaaacaa tcgtaaacga ctcacgtttg ttatcgactg tgattgccgg cagcaacatc
    18061 atccagaatt ttagcttcga gctaagttgt gatggcgagc ctttctacca aggtaaagcg
    18121 gtatttggtt acttcaaggg cgatgcgctg aaaaaccaac tcggcataga caacggcaag
    18181 atcacacagc cttggcatgt gcaaaatgac atagccgccg atagccaaat caatctgtta
    18241 gataaacagc atcgcagctt caacgcgcca gaaggtcagc cgcattaccg tttagcgggc
    18301 ggtcaactta actttatcga caaggctgaa atcgtaacag ccggcggtaa agcgggcctt
    18361 ggctatttat acgccgagcg caccattgac ccgagtgatt ggttcttcca attccacttc
    18421 catcaagatc cggtaatgcc aggctcatta ggggttgaag cgattatcga gctgatgcaa
    18481 acctatgcga ttgaccaaga ccttggcgct ggctttaaga gtccaaaatt cggccagata
    18541 ttatcggata tcaaatggaa gtatcgcggc caaattaacc cattaaacaa acagatgtcg
    18601 ctggatgtgc acattaccag cgtgacagac gacaatggca aacgcatcat tatgggcgat
    18661 gccaacttga gtaaagatgg cctgcgaatt tatgaagtca aagatatcgc catctgtatt
    18721 gaagaagctt aatgcggtaa attctattta ttgaataact taaaaataat cctgccgctg
    18781 cgttggcttt ttacacccga actttttact caagtaatag caacgcagca gcattaaaaa
    18841 cgagacccaa gatgactagc catactctag atcaattcaa tagtaataac gaaaaactca
    18901 gcccttggcc gtggcaagtc aacgatgcag agctgagctt tgatatcgac tcattaggca
    18961 aaaaactcaa agatttaagc caagcctgct acttagtcaa tcacagcgaa aaaggcttag
    19021 gcatagcgca aacggccgaa gtgaccacca gtgacagcca agcgccattg ggctcacatc
    19081 ctgtcagcgc ctttgcccct gcccttggca cccaaagttt aggcgacagt aattttcgcc
    19141 gcgtccacgg tgtcaaatac gcttactacg ccggcgcgat ggcaaacggt attgcctcgg
    19201 aagaactggt tatcgcccta ggccaagcgg gcattttgtg ctcatttggc gcggcggggt
    19261 taattccatc gcgcgttgaa gcagccatta cacgcattca agcagcgctg cccaatggcc
    19321 cctacgcctt taacttaatt cacagcccaa gcgagcccgc attagagcgc ggcagcgttg
    19381 agctgttttt aaaacataaa gtgcgcacgg tcgaagcctc agcattttta ggtttaacac
    19441 cgcaaatcgt ctattaccgt gcagcggggt tgagccgcga cgaacatggc gagatagtca
    19501 ttggcaataa agtcatagca aaaatcagcc gcaccgaagt cgcgactaag tttatggagc
    19561 cagcgcctgc caaaatcctc cagcaattag tgagtgatgg tcttatcagc caagatcaaa
    19621 tggcgatggc gcaactcgtg ccaatggcgg acgacatcac ggccgaagcc gactcaggcg
    19681 gccataccga caatcgtcca ttggtcacgc tattgccgac gattttggcg ctcaaagatg
    19741 aaatccaagc taagtatcaa tataaaacgc ccatccgtgt gggcgcaggc ggcggcgtcg
    19801 gcacacccga tgcagcatta gccaccttca acatgggcgc ggcctttatc gtcacaggtt
    19861 caatcaacca agcttgcgtc gaagcgggcg ccagcgaaca cacccgtaag ttactcgcca
    19921 ccacagaaat ggccgatgtg actatggcgc ctgccgctga tatgttcgaa atgggcgtga
    19981 aattacaagt ggttaagcgc ggcactttgt tcccgatgcg cgccaataag ctttatgaaa
    20041 tctacacccg ttacgattcg attgatgcca tccctgcgga cgagcgtaaa aagctcgaag
    20101 agcaagtgtt ccgctcatca ctcgatgaca tttgggctgg cacagtcgcc cactttaacg
    20161 agcgcgatcc taagcaaatc gagcgtgcac tggataaccc aaaacgtaag atggcgttga
    20221 ttttccgctg gtatttgggt ctgtcgagcc gctggtcaaa cacaggtgaa gtcggccgcg
    20281 aaatggatta ccaaatctgg gcaggcccag cactgggtgc atttaacgct tgggcgaaag
    20341 gcagttattt agatgactat aaggcccgta atgcggtgga tttagccaaa catttaatgg
    20401 tgggcgcagc atatcaatcc cggattaact tgctgttatc tcaaggtgcg agcattccgg
    20461 tcacactact acgctggaaa ccgctgaatc gtttttaa
//
