BGC0000865 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000865 (Photobacterium profundum SS9)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	hglE-KS,PUFA	1	33,099	eicoseicosapentaenoic acid	other:other	100%

BGC0000865 - Region 1 - PUFA,hglE-KS

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Location: 1 - 33,099 nt. (total: 33,099 nt) Show pHMM detection rules used

Region on contig edge.

hglE-KS: (hglE or hglD)
PUFA: PUFA_KS

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,100
Label		BGC0000865

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000865	1.95	Other	eicoseicosapentaenoic acid	Photobacterium profundum SS9
BGC0002648	0.75	Polyketide	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000861	0.75	Other	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000863	0.65	Other	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000862	0.61	Other	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000284	0.49	Polyketide	phenolic lipids	Azotobacter vinelandii DJ
BGC0000869	0.48	Other	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0002483	0.46	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0000864	0.46	Other	eicosapentaenoic acid-like compound	Moritella marina ATCC 15381
BGC0001872	0.44	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000865	0.99	Other	eicoseicosapentaenoic acid	Photobacterium profundum SS9
BGC0002648	0.70	Polyketide	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000861	0.70	Other	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000863	0.66	Other	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000862	0.64	Other	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000284	0.58	Polyketide	phenolic lipids	Azotobacter vinelandii DJ
BGC0000869	0.57	Other	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0002483	0.56	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0000864	0.56	Other	eicosapentaenoic acid-like compound	Moritella marina ATCC 15381
BGC0001872	0.55	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33099:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AAL01056.1

AMP-binding (19..466): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: --FFIASPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

pfaA

PKS_AT (598..900): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 99.5
Methoxymalonyl-CoA: 31.9
inactive: 31.4
Methylmalonyl-CoA: 23.0
fatty_acid: 16.8
Isobutyryl-CoA: 13.6
Propionyl-CoA: 11.6
CHC-CoA: 10.5
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

pfaB

PKS_AT (326..630): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0