LOCUS       BGC0000870              3890 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv complete genome.
ACCESSION   BGC0000870
VERSION     BGC0000870
KEYWORDS    .
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
COMMENT     On or before Feb 1, 2013 this sequence version replaced BX842572.1,
            BX842573.1, BX842574.1, BX842575.1, BX842576.1, BX842577.1,
            BX842578.1, BX842579.1, BX842580.1, BX842581.1, BX842582.1,
            BX842583.1, BX842584.1, AL123456.2.
            On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:53:39
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..906)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0642c"
                     /db_xref="EnsemblGenomes-Tr:CCP43385"
                     /db_xref="GOA:Q79FX8"
                     /db_xref="InterPro:IPR003333"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="PDB:2FK7"
                     /db_xref="PDB:2FK8"
                     /db_xref="PDB:3HA3"
                     /db_xref="PDB:3HA5"
                     /db_xref="PDB:3HA7"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mmaA4"
                     /locus_tag="Rv0642c"
                     /note="Rv0642c, (MTCY20H10.23c), len: 301 aa. MmaA4,methoxy
                     mycolic acid synthase 4 (methyltransferase) (see citations
                     below). Equivalent to AAC44876|AAC44876.1|cmaA methyl
                     transferase (mycolic acid modification protein) from
                     Mycobacterium bovis BCG strain Pasteur (298 aa);
                     NP_302280.1|NC_002677 methyl mycolic acid synthase 4 from
                     Mycobacterium leprae (298 aa); and highly similar to others
                     from Mycobacteria e.g. downstream ORF
                     P72027|mmaA3|Rv0643c|MTCY20H10.24c putative methoxy mycolic
                     acid synthase 3 from Mycobacterium tuberculosis (293 aa).
                     Phosphorylated in vitro by PknJ|Rv2088 (See Jang et
                     al.,2010)."
                     /product="Methoxy mycolic acid synthase 4 MmaA4 (methyl
                     mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid
                     synthase)"
                     /protein_id="CCP43385.1"
                     /transl_table=11
                     /translation="MTRMAEKPISPTKTRTRFEDIQAHYDVSDDFFALFQDPTRTYSCA
                     YFEPPELTLEEAQYAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRRAVERFDVNVIGLTL
                     SKNQHARCEQVLASIDTNRSRQVLLQGWEDFAEPVDRIVSIEAFEHFGHENYDDFFKRC
                     FNIMPADGRMTVQSSVSYHPYEMAARGKKLSFETARFIKFIVTEIFPGGRLPSTEMMVE
                     HGEKAGFTVPEPLSLRPHYIKTLRIWGDTLQSNKDKAIEVTSEEVYNRYMKYLRGCEHY
                     FTDEMLDCSLVTYLKPGAAA"
     subregion       1..3890
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000870"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..3890
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..906)
                     /gene="mmaA4"
                     /locus_tag="Rv0642c"
     gene            complement(971..1852)
                     /gene="mmaA3"
                     /locus_tag="Rv0643c"
     CDS             complement(971..1852)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0643c"
                     /db_xref="EnsemblGenomes-Tr:CCP43386"
                     /db_xref="GOA:P0CH91"
                     /db_xref="InterPro:IPR003333"
                     /db_xref="InterPro:IPR029063"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mmaA3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 58.5; E-value:
                     1.1e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Rv0643c"
                     /note="Rv0643c, (MTCY20H10.24c), len: 293 aa. MmaA3,methoxy
                     mycolic acid synthase 3 (methyltransferase) (see citations
                     below). Equivalent to AAC44875|AAC44875.1|cmaB methyl
                     transferase (mycolic acid modification protein) from
                     Mycobacterium bovis BCG strain Pasteur (289 aa); and highly
                     similar to others from Mycobacteria e.g. upstream ORF
                     P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy mycolic
                     acid synthase 4 from Mycobacterium tuberculosis (301 aa)."
                     /product="Methoxy mycolic acid synthase 3 MmaA3 (methyl
                     mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid
                     synthase)"
                     /protein_id="CCP43386.1"
                     /transl_table=11
                     /translation="MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFE
                     RDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKN
                     QHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNA
                     MPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVT
                     KAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRM
                     GYIDCNQFTLAK"
     gene            complement(2000..2863)
                     /gene="mmaA2"
                     /locus_tag="Rv0644c"
     CDS             complement(2000..2863)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0644c"
                     /db_xref="EnsemblGenomes-Tr:CCP43387"
                     /db_xref="GOA:Q79FX6"
                     /db_xref="InterPro:IPR003333"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="PDB:1TPY"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mmaA2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 61.2; E-value:
                     1.8e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Rv0644c"
                     /note="Rv0644c, (MTCY20H10.25c), len: 287 aa. MmaA2,methoxy
                     mycolic acid synthase 2 (methyltransferase) (see citations
                     below). Equivalent to AAC44874|AAC44874.1|cmaC methyl
                     transferase (mycolic acid modification protein) from
                     Mycobacterium bovis BCG strain Pasteur (287 aa); and highly
                     similar to others from Mycobacteria e.g. upstream ORF
                     P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy mycolic
                     acid synthase 4 from Mycobacterium tuberculosis (301 aa).
                     Note that alternative start is at position 739247."
                     /product="Methoxy mycolic acid synthase 2 MmaA2 (methyl
                     mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid
                     synthase)"
                     /protein_id="CCP43387.1"
                     /transl_table=11
                     /translation="MVNDLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTL
                     EEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAAHVQ
                     KSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGV
                     LLLHTITGLTRQQMVDHGLPLTLWLARFLKFIATEIFPGGQPPTIEMVEEQSAKTGFTL
                     TRRQSLQPHYARTLDLWAEALQEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVN
                     QFTLAK"
     gene            complement(3030..3890)
                     /gene="mmaA1"
                     /locus_tag="Rv0645c"
     CDS             complement(3030..3890)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0645c"
                     /db_xref="EnsemblGenomes-Tr:CCP43388"
                     /db_xref="GOA:P9WPB1"
                     /db_xref="InterPro:IPR003333"
                     /db_xref="InterPro:IPR029063"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="mmaA1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 58.3; E-value:
                     1.3e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Rv0645c"
                     /note="Rv0645c, (MTCY20H10.26c), len: 286 aa. MmaA1,methoxy
                     mycolic acid synthase 1 (methyltransferase) (see citations
                     below). Equivalent to NP_302279.1|NC_002677 methyl mycolic
                     acid synthase 1 from Mycobacterium leprae (286 aa); and
                     highly similar to others from Mycobacteria e.g. upstream
                     ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy
                     mycolic acid synthase 4 from Mycobacterium tuberculosis
                     (301 aa)."
                     /product="Methoxy mycolic acid synthase 1 MmaA1 (methyl
                     mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid
                     synthase)"
                     /protein_id="CCP43388.1"
                     /transl_table=11
                     /translation="MAKLRPYYEESQSAYDISDDFFALFLDPTWVYTCAYFERDDMTLE
                     EAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGLTLSRNHYERSKD
                     RLAAIGTQRRAEARLQGWEEFEENVDRIVSFEAFDAFKKERYLTFFERSYDILPDDGRM
                     LLHSLFTYDRRWLHEQGIALTMSDLRFLKFLRESIFPGGELPSEPDIVDNAQAAGFTIE
                     HVQLLQQHYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINVAQ
                     FTMTK"
ORIGIN
        1 ttaggccgcg gcacccggct tgaggtaggt caccaggctg cagtcgagca tctcgtcggt
       61 gaagtagtgc tcgcagccac gcaaatactt catgtagcgg ttgtagacct cttcggaggt
      121 gacctcgatg gccttgtcct tattggactg cagcgtgtcc ccccagatcc gcagcgtctt
      181 gatgtaatgc gggcgcaacg agagcggctc cgggacggtg aaaccggcct tctcgccgtg
      241 ttcgaccatc atctcggtgg acggcaggcg gccgccggga aatatctcgg tgacgatgaa
      301 cttgatgaaa cgcgccgtct cgaagctcag cttcttaccg cgggccgcca tctcgtaggg
      361 gtggtagctg acgctgctct ggacggtcat ccggccgtcg gcgggcatga tgttgaaaca
      421 ccgcttgaag aagtcgtcgt agttctcgtg cccgaagtgc tcgaaggctt cgatcgacac
      481 aatccggtcg acgggttcgg cgaaatcctc ccagccttgc agcagcactt gacgtgagcg
      541 gttggtgtcg atcgaagcca gcacttgctc gcagcgggcg tgctggttct tggacaacgt
      601 caggccgatg acgttaacgt cgaaccgctc gacggcgcgc ctcatggtgg tgccccaacc
      661 gcacccaatg tccagcagcg tcatgcccgg cttgaggtcc agcttgtcca ggttgaggtc
      721 gaccttggcg tattgggctt cttcgagcgt gagctccggt ggctcgaagt aggcacagct
      781 gtaagttcgg gtcgggtcct ggaacagggc gaagaaatca tcggagacgt cgtagtgcgc
      841 ttggatgtct tcgaagcgtg tccgtgtctt ggttgggcta atcggtttct cggccattct
      901 cgtcatgttc tcctggatgg tgtcagttac cggtggctgt gcacccatag cccgtcggtg
      961 gcacgaaagt ctacttggcc agcgtgaact ggttgcagtc gatgtagccc attcggaacg
     1021 ccttggcgca gccggtcagg tatttcatgt accgctcgta tacctctgcg gactggatct
     1081 cgatggcctc gtccttgtgc gcttgaagcg cctcggccca caggtcaaga gtcctggcga
     1141 agtgcggttg cagggactgg atatcggtaa tggtgaaacc ggccttcgtc acatgctcct
     1201 cgatcgtctc gatcgtcggc aaccggccgc ccgggaagat gtcggtcacg atgaaccgga
     1261 tgaatttggc catctccatg gtcaacggta tgccgcgctc gatgacctgc tttacgtgca
     1321 agccggtgat cgagtgcagc agcatcacgc cgtccgcggg catcgcgttg taggcgaact
     1381 tgaagaagtc atcgtagcgc tcgaaaccga agtgctctat cgcttcgatg gttacgatgc
     1441 ggtccaccgg ctcgctgaag ttggcccagt cgctcagcag tacccggtgc gagcggttgg
     1501 tgtcgacctt gtcgagcact tgctggcagt aggcgtgctg atttttcgac agggtcaagc
     1561 cgacgacgtt gacgtcgtag cgctcgacgg cacgcttcat gaccgaaccc cagccgcagc
     1621 ccacgtcgag cagtgtcatt cccggttcta gccccagctt gcccagggtt aggtccagct
     1681 tggcgacctg tgcttcgtgc aaggtcatgt cgtcgcgctc gaagtaggcg cagctgtagg
     1741 tccgagtcgg atcctggaac agcgcgaaga acgcatctga aaggtcgtaa tgggcttgga
     1801 cgtcgtcgac attggaccga gactttgtgg tgcccgttga gttatcagac atgtgtcctc
     1861 ccactgtgag gggcaccttc agcaggtggc catccccggc accctacacg gtgcatggca
     1921 catcgcccgc attcgcgctc gcatgcgccg gtctttctcg atcgggattt gccagatatc
     1981 accctggccg gcgcaatcac tacttcgcca gcgtgaactg gttgacgtcg atgtagccga
     2041 cccggaacag cttggcgcag ccggtcaggt atttcatgta ccgctcgtag acctcttcgg
     2101 actggatcgc gatggcctcg cttttgtgtt cctgcagcgc ctcggcccac aggtcgaggg
     2161 tcctggcgta atgcggctgc agcgactggc ggcgagtcag cgtgaaaccc gtcttcgccg
     2221 actgttcctc aaccatttca atcgtcggag gttggccccc cgggaagatt tcggtcgcga
     2281 tgaacttgag aaagcgggcc agccacaacg tgagcggcaa gccgtggtcg accatctgct
     2341 gcctggtcag gccggtgatc gtgtgcagca gcaacacgcc atcgggcggc aggattttgt
     2401 gggcccgggc gaagaagtcg gcgtgacgat cgtggccgaa gtgctcgaac gcgccgatcg
     2461 acacgatgcg gtcgacgggc tcgttgaact gctcccatcc cgccagcaac actcgcctgt
     2521 cgcgcggggt gtccatctcg tcgaacgact tctgcacatg ggcggcctgg ttcttcgaca
     2581 atgtcaggcc gacgacgttg acgtcatact gcgcgatcgc gcgccgcatg gtggcgcccc
     2641 agccgcaacc gatatcgagc agcgtcatgc cgggctgcag acctagcttg cccagcgcca
     2701 ggtcgatctt ggcgatctgg gcctcttcca gcgtcatgtc ctcgcgttcg aaatgcgcgc
     2761 agctgtaggt ctgggtcgga tccaggaaca gccggaagaa gtcgtcggac aggtcgtagt
     2821 gtgcctgcac gtcctcgaag tgcggcgtta ggtcgttgac catgaggtgt aatgcctttc
     2881 cggaccctag gtggcctttc ggtgcttgca cggaacgcac cgatgcttcc ccctccccgc
     2941 atgctcgagg catgctatcc gatacagggc cgccgcacta aaccgcgatc gaatttgccc
     3001 aggtcaggga acggatatga gcggacgagc tacttggtca tggtgaactg ggcgacgttg
     3061 attaggcctc tgcggaagcg ctccgcgcat ccggtcagat agtgcatgaa gttgttgtag
     3121 acctcttcgg actgtacggc gatggcgcgt tcgcgggcag cctgtaggtt ggcggcccat
     3181 gcatcgagag tccgtgcgta gtgctgctgc agcagctgga catgctcgat ggtgaagccc
     3241 gcggcctgcg cattgtcgac aatgtcgggc tccgatggca gctcgccgcc cgggaagatc
     3301 gactcccgca ggaatttgag gaatcgaagg tcgctcatcg tcagcgcaat gccctgttcg
     3361 tgcagccacc tgcggtcgta ggtgaacagg ctgtgcagta gcatccgccc gtcatcgggc
     3421 aggatgtcgt aggagcgttc gaagaacgtc agataccgct cctttttgaa cgcgtcgaat
     3481 gcctcaaagc tgacgatccg gtcgacgttc tcttcaaact cttcccagcc ctgcagccgg
     3541 gcctcggcgc gccgttgcgt tccgattgcg gccaggcggt ctttgctgcg ttcatagtga
     3601 ttccggctga gcgtgaggcc gatgacattg acgtcgtact tctccacggc ccgaacgagc
     3661 gccccgcccc acccgcaacc cacgtcgagt agcgtcatcc ccggttcgag gttcagcttg
     3721 tccaacgcca gatccacctt ggccagttgc gcctcttcca gcgtcatatc gtcacgctcg
     3781 aaataggcgc aggtgtagac ccaggtggga tcgaggaaca acgcgaagaa gtcatccgaa
     3841 atgtcgtaag ccgactgtga ctcttcgtaa tatggtctca gcttggccat
//
