BGC0000873 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000873 (Saccharothrix mutabilis subsp. capreolus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	arylpolyene,nucleoside	1	33,676	High	A-201A	other:other

BGC0000873 - Region 1 - arylpolyene,nucleoside

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Location: 1 - 33,676 nt. (total: 33,676 nt) Show pHMM detection rules used

Region on contig edge.

arylpolyene: (APE_KS1 or APE_KS2)
nucleoside: (LipM or LipV or LipU or TunD or pur6 or pur10 or nikJ or nikO or truD)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,677
Label		BGC0000873

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

ata4: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ataP10: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acylase aminotransferase glycosyltransferase methyltransferase

ata13: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

ata5: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

ata6: methyltransferase

smcogs: SMCOG1089: methyltransferase

ataP4: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

ataPKS1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: phosphatase

ataP3: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Lyases: dehydratase

ata12: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

ata17: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

ata18: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

ataPKS3: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000873.3	1.50	other (other)	A-201A	Saccharothrix mutabilis subsp. capreolus
BGC0000878.5	0.62	other (other)	puromycin	Streptomyces alboniger
BGC0001276.3	0.56	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.56	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.56	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001160.5	0.54	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000772.5	0.38	saccharide	lipopolysaccharide	Brucella melitensis
BGC0001138.5	0.36	other (nucleoside)	a201a	Marinactinospora thermotolerans
BGC0002171.2	0.34	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000873.3	0.99	other (other)	A-201A	Saccharothrix mutabilis subsp. capreolus
BGC0000878.5	0.66	other (other)	puromycin	Streptomyces alboniger
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001138.5	0.54	other (nucleoside)	a201a	Marinactinospora thermotolerans
BGC0000772.5	0.51	saccharide	lipopolysaccharide	Brucella melitensis
BGC0002171.2	0.51	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

ataPKS1: mmal

PKS_AT (104..391): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 70.8%; Propionyl-CoA: 66.7%; Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 113.2
Malonyl-CoA: 97.8
Isobutyryl-CoA: 87.3
Methoxymalonyl-CoA: 83.1
Ethylmalonyl-CoA: 68.9
Propionyl-CoA: 47.7
2-Methylbutyryl-CoA: 43.8
Benzoyl-CoA: 42.7
fatty_acid: 38.1
trans-1,2-CPDA: 35.9
Acetyl-CoA: 35.1
3-Methylbutyryl-CoA: 27.3
inactive: 27.1
CHC-CoA: 20.4

ata18: X

AMP-binding (17..369): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SYEQVAHQIK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor