BGC0000875: caprazamycin biosynthetic gene cluster from Streptomyces sp. MK730-62F2
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Location: 1 - 28,072 nt. (total: 28,072 nt).
This entry is originally from NCBI GenBank FJ490409.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000875
Short description caprazamycin biosynthetic gene cluster from Streptomyces sp. MK730-62F2
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Caprazamycins are a mixture of derivatives containing different fatty acyl chain lengths, saturation and branching. Non-glycosylated and sulfated derivatives can be found in the extracts too."
Biosynthetic class(es)
  • other (nucleoside)
  • saccharide (hybrid/tailoring)
Loci
FJ490409.1
via Knock-out studies, Heterologous expression, Enzymatic assays
Compounds
  • caprazamycin
  • caprazamycin aglycon
Species Streptomyces sp. MK730-62F2 [taxonomy]
References
Chemical products information
caprazamycin Evidence:
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C54H89N5O22
Chemical database entries
PubCHEM
caprazamycin aglycon Evidence:
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C45H73N5O18
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACQ63617.1
  • cpz9
 103 - 1149 (+) AraC family transcriptional regulator
  • Regulation
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  • ACQ63618.1
  • cpz10
 1299 - 1847 (+) beta-hydroxylase
  • Scaffold biosynthesis
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  • ACQ63619.1
  • cpz11
 1867 - 2499 (+) SAM-dependent methyltransferase
  • Tailoring
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  • ACQ63620.1
  • cpz12
 2496 - 3065 (+) TmrB-like kinase
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    • ACQ63621.1
    • cpz13
    		 3136 - 4461 (+) amino-cyclopropyl transferase
    • Scaffold biosynthesis
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    • ACQ63622.1
    • cpz14
    		 4466 - 5740 (+) transaldolase
    • Scaffold biosynthesis
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    • ACQ63623.1
    • cpz15
    		 5822 - 6646 (+) Fe(II)-dependent UMP dioxygenase
    • Scaffold biosynthesis
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    • ACQ63624.1
    • cpz16
    		 6643 - 7344 (+) nucleotidyltransferase
    • Precursor biosynthesis
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    • ACQ63625.1
    • cpz17
    		 7344 - 8477 (+) glycosyltransferase
    • Scaffold biosynthesis
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    • ACQ63626.1
    • cpz18
    		 8474 - 9748 (+) aminotransferase
    • Scaffold biosynthesis
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    • ACQ63627.1
    • cpz19
    		 9745 - 11127 (+) pyrimidine-nucleoside phosphorylase
    • Scaffold biosynthesis
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    • ACQ63628.1
    • cpz20
    		 11120 - 12184 (+) acyl-CoA synthase
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      • ACQ63629.1
      • cpz21
      		 12184 - 13686 (+) acyltransferase
      • Scaffold biosynthesis
      • Activity assay
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      • ACQ63630.1
      • cpz22
      		 13683 - 17399 (+) ABC multidrug resistance transporter
      • Transport
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      • ACQ63631.1
      • cpz23
      		 17396 - 18430 (+) acyltransferase
      • Scaffold biosynthesis
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      • ACQ63632.1
      • cpz24
      		 18716 - 20512 (+) hypothetical protein
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        • ACQ63633.1
        • cpz25
        		 20604 - 21629 (+) acyl-CoA dehydrogenase
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          • ACQ63634.1
          • cpz26
          		 21682 - 22935 (+) SAM-dependent methyltransferase
          • Tailoring
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          • ACQ63635.1
          • cpz27
          		 22932 - 23510 (+) TmrB-like kinase
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            • ACQ63636.1
            • cpz28
            		 23591 - 24781 (+) sugar O-methyltransferase
            • Tailoring
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            • ACQ63637.1
            • cpz29
            		 24825 - 25622 (+) sugar O-methyltransferase
            • Tailoring
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            • ACQ63638.1
            • cpz30
            		 25619 - 26878 (+) sugar O-methyltransferase
            • Tailoring
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            • ACQ63639.1
            • cpz31
            		 26882 - 28072 (+) rhamnosyltransferase
            • Tailoring
            • Activity assay
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            Biosynthesis information
            Annotation changelog

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Remove duplicated citations
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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