BGC0000880: tunicamycin B1 biosynthetic gene cluster from Streptomyces chartreusis NRRL 3882
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Location: 8,616 - 20,609 nt. (total: 11,994 nt).
This entry is originally from NCBI GenBank HQ172897.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000880
Short description tunicamycin B1 biosynthetic gene cluster from Streptomyces chartreusis NRRL 3882
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The core sugar components of tunicamycin are identical to corynetoxin, however between the two variations in lipid side chain exist."
Biosynthetic class(es)
  • other (nucleoside)
Loci
HQ172897.1
8616 - 20609
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • tunicamycin B1
Species Streptomyces chartreusis NRRL 3882 [taxonomy]
References
Chemical products information
tunicamycin B1 Evidence:
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C38H62N4O16
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADP94221.1
  • tunA
 8616 - 9581 (+) tunA
  • Precursor biosynthesis
  • Activity assay
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  • ADP94222.1
  • tunB
 9581 - 10597 (+) tunB
  • Precursor biosynthesis
  • Knock-out
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  • ADP94223.1
  • tunC
 10601 - 11557 (+) TunC
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    • ADP94224.1
    • tunD
    		 11557 - 12981 (+) TunD
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      • ADP94225.1
      • tunE
      		 12978 - 13682 (+) TunE
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        • ADP94226.1
        • tunF
        		 13679 - 14662 (+) tunF
        • Precursor biosynthesis
        • Activity assay
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        • ADP94227.1
        • tunG
        		 14664 - 15275 (+) TunG
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          • ADP94228.1
          • tunH
          		 15272 - 16819 (+) TunH
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            • ADP94229.1
            • tunI
            		 16822 - 17736 (+) TunI
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              • ADP94230.1
              • tunJ
              		 17720 - 18508 (+) TunJ
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                • ADP94231.1
                • tunK
                		 18548 - 18793 (+) TunK
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                  • ADP94232.1
                  • tunL
                  		 18790 - 19479 (+) TunL
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                    • ADP94233.1
                    • tunM
                    		 19487 - 20137 (+) TunM
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                      • ADP94234.1
                      • tunN
                      		 20151 - 20609 (+) TunN
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                        Biosynthesis information
                        Annotation changelog

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: Q466Z24KJDYPHZY2353Y4FFQ)
                        • (ID: RJXZFYIPTBJ27AV3IUUT4BRL)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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