Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000880.1:
Cluster 1Nucleoside111994

BGC0000880, tunicamycin biosynthetic gene cluster from Streptomyces chartreusis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Tunicamycin B1
ChemSpider ID: 27471420
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial, Antifungal, Cytotoxic
Molecular target: MraY

Class-specific details

Biosynthetic class(es):
Nucleoside

Gene cluster description

tunicamycin (BGC0000880). Gene Cluster 1. Biosynthetic class = Nucleoside. GenBank HQ172897, positions 8616-20609. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Comments:The core sugar components of tunicamycin are identical to corynetoxin, however between the two variations in lipid side chain exist.
Contact for this cluster:David Widdick and Juan Pablo Gomez-Escribano (John Innes Centre)

Literature references

1. Wyszynski FJ et al. (2012) Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates. Nat Chem 4(7):539-46. doi: 10.1038/nchem.1351.