BGC0000887: saxitoxin biosynthetic gene cluster from Dolichospermum circinale AWQC131C
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Location: 1 - 30,991 nt. (total: 30,991 nt).
This entry is originally from NCBI GenBank DQ787201.1.

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core biosynthetic genes
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000887
Short description saxitoxin biosynthetic gene cluster from Dolichospermum circinale AWQC131C
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Alkaloid (Purine)
Loci NCBI GenBank: DQ787201.1
Compounds
  • saxitoxin
  • gonyautoxin 2
  • gonyautoxin 3
  • toxin C2
  • toxin C3
  • gonyautoxin 5
  • decarbamoylsaxitoxin
  • decarbamoylgonyautoxin 2
  • decarbamoylgonyautoxin 3
Species Dolichospermum circinale AWQC131C [taxonomy]
References
Chemical products information
saxitoxin [synonyms: saxitoxin hydrate]
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C10H17N7O4
Chemical database entries
PubCHEM
ChEBI
ChEMBL
ChemSpider
gonyautoxin 2 [synonyms: gonyautoxin ii]
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C10H17N7O8S1
Chemical database entries
PubCHEM
ChEBI
ChemSpider
gonyautoxin 3 [synonyms: gonyautoxin iii]
(no structure information available)
Chemical database entries
ChemSpider
toxin C2 [synonyms: gonyautoxin 8, gonyautoxin viii]
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C10H17N7O11S2
Chemical database entries
PubCHEM
ChemSpider
toxin C3
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C10H17N7O12S2
gonyautoxin 5 [synonyms: gonyautoxin v]
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C10H17N7O7S1
Chemical database entries
PubCHEM
ChemSpider
decarbamoylsaxitoxin
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C9H16N6O3
Chemical database entries
PubCHEM
ChemSpider
decarbamoylgonyautoxin 2 [synonyms: decarbamoylgonyautoxin ii]
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C9H17N6O7S1
decarbamoylgonyautoxin 3 [synonyms: decarbamoylgonyautoxin iii]
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C9H17N6O7S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABI75122.1
  • sxtB
 1817 - 2794 (-) cytidine deaminase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75123.1
  • sxtA
 2800 - 6504 (-) polyketide synthase-related protein
  • Scaffold biosynthesis
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  • ABI75124.1
  • sxtE
 6750 - 7226 (-) chaperone-like protein
  • Unknown
Sequence-based prediction
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  • ABI75125.1
  • sxtD
 7741 - 8499 (-) sterole desaturase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75126.1
  • sxtP
 8576 - 10024 (+) putative saxitoxin-binding protein
  • Unknown
Sequence-based prediction
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  • ABI75127.1
 10049 - 10825 (+) Unknown
  • Unknown
Sequence-based prediction
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  • ABI75128.1
  • sxtR
 10836 - 11639 (+) acyl-CoA N-acyltransferase
  • Unknown
Sequence-based prediction
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  • ABI75129.1
 14474 - 15361 (+) transposase
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  • ABI75130.1
 15960 - 16916 (-) permease
  • Transport
Sequence-based prediction
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  • ABI75131.1
 17125 - 17751 (+) hypothetical protein
  • Unknown
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  • ABI75132.1
  • sxtS
 18030 - 18755 (+) phytanoyl-CoA dioxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75133.1
  • sxtT
 18851 - 19870 (+) phenylpropionate dioxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75134.1
  • sxtU
 20019 - 20768 (+) short-chain alcohol dehydrogenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75135.1
  • sxtN
 20821 - 21690 (+) sulfotransferase
  • Tailoring (Sulfation)
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  • ABI75136.1
  • sxtG
 21809 - 22942 (+) amidinotransferase
  • Scaffold biosynthesis
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  • ABI75137.1
  • sxtH
 23005 - 24024 (+) phenylpropionate dioxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75138.1
  • sxtM
 24071 - 25528 (+) sodium-driven multidrug and toxic compound extrusion protein
  • Transport
Sequence-based prediction
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  • ABI75139.1
  • sxtI
 25516 - 27354 (+) NodU/CmcH-related carbamoyltransferase
  • Scaffold biosynthesis
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  • ABI75140.1
  • sxtJ
 27397 - 27801 (+) hypothetical protein
  • Unknown
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  • ABI75141.1
  • sxtK
 27801 - 27965 (+) hypothetical protein
  • Unknown
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  • ABI75142.1
  • sxtL
 27976 - 29256 (+) GDSL-lipase
  • Unknown
Sequence-based prediction
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  • ABI75143.1
  • sxtO
 29274 - 29843 (+) adenylylsulfate kinase
  • Activation / processing
Sequence-based prediction
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  • ABI75144.1
 30059 - >30991 (-) SMF protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: EI7LXM427LE4WIOQ5U54V3BB, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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