LOCUS       BGC0000891             11263 bp    DNA     linear   BCT 05-NOV-2013
DEFINITION  Pseudoalteromonas luteoviolacea 2ta16 Pl2ta16__Contig158, whole
            genome shotgun sequence.
ACCESSION   BGC0000891
VERSION     BGC0000891
KEYWORDS    .
SOURCE      Pseudoalteromonas luteoviolacea 2ta16
  ORGANISM  Pseudoalteromonas luteoviolacea 2ta16
            Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
            Pseudoalteromonadaceae; Pseudoalteromonas.
COMMENT     Bacteria available from Eric Allen, Scripps Institution of
            Oceanography, 9500 Gilman Dr., MC0202, La Jolla, CA 92093-0202,
            USA.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 14:22:58
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 32482
            Orig. end    :: 43745
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1248)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 123.6; E-value: 1.3e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PL2TA16_01232"
                     /product="NAD(FAD)-dependent dehydrogenase"
                     /protein_id="ESP90841.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.1e-65, bitscore:
                     209.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRCVIIGGGHAGAQACTSLRREGWTGQIILLTDEDSLPYHRPPL
                     SKTYLQNKVSAQQLLIRPLNAYRKDDVEVKLNTRVERIEPAIQSIVLQTGERLSYDKLL
                     ICTGSRARKADCMGADLNNVFYIKTLKDIEKLSASINSEKGKPNKRRIVMVGGGYIGLE
                     TAAVLKKMGHDVSIIERESRLLARVTAQSISSFYHKLHKSNGIKIFTDTNVIAFQGKDT
                     VSTVLCEDKVIPADIVVVGIGAKTNVELAKSAGLLIENDGIVINELCQTTDNNIYAAGD
                     CTIGIEHHSGLATRIESVPNALEQAKTAAATICGKHKPVTAVPWFWSDQFDCKIQIAGL
                     NQGYDETILRQCNEQALSLWYLKQGKVIAADCINCAKEFMAAKKIIALKLPIPKETLLN
                     TDIDLFQALAQLTQPS"
     subregion       1..11263
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11263
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1248)
                     /locus_tag="PL2TA16_01232"
     gene            complement(1260..1580)
                     /locus_tag="PL2TA16_01233"
     CDS             complement(1260..1580)
                     /codon_start=1
                     /locus_tag="PL2TA16_01233"
                     /product="ferredoxin"
                     /protein_id="ESP90842.1"
                     /transl_table=11
                     /translation="MPEITFIDFAGNETKVDVPNGTSLMQAAMENMVEGIEAECGGSGS
                     CATCHCYLTTDWQGKIAEPNSNESDMLELVAEPKDLSRLSCQVMVSDEHHGLQVHLPKS
                     QY"
     gene            complement(1591..2181)
                     /locus_tag="PL2TA16_01234"
     CDS             complement(1591..2181)
                     /codon_start=1
                     /locus_tag="PL2TA16_01234"
                     /product="hypothetical protein"
                     /protein_id="ESP90843.1"
                     /transl_table=11
                     /translation="MKQGNNHLVTPVERAATPHLEPIYQAIENNLGFIPNGILTMAKNP
                     MLAQAFGQLFGCLSRFEHINSELKWAIATISSNAAGCQYCQGHFSHIASRVNVNRAKVL
                     AAFEFETNVLFDDAERAALRFAFACSTSPAHLEKSHYETLGKHYSEEAVIEIAAVIAIC
                     GFLNRWNTAMDSQLEADPAAILDEINQITKFTV"
     gene            2467..3543
                     /locus_tag="PL2TA16_01235"
     CDS             2467..3543
                     /NRPS_PKS="Domain: PP-binding (10-72). E-value: 3.6e-08.
                     Score: 25.7. Matches aSDomain:
                     nrpspksdomains_PL2TA16_01235_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036:alpha/beta hydrolase fold protein (Score: 76.3;
                     E-value: 5.2e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PL2TA16_01235"
                     /product="putative hydrolase or acyltransferases
                     (alpha/beta hydrolase superfamily)"
                     /protein_id="ESP90844.1"
                     /sec_met_domain="PP-binding (E-value: 6.5e-09, bitscore:
                     25.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.8e-16, bitscore:
                     50.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.9e-13, bitscore: 40.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEELIEFINQDLLEGAAPDLDQHTPLLELGILNSLSMVRLLAHV
                     DQRYGAKIPEHDITPVHFENIETLCALIKVLSTEEQSQTQEASSELDRLVKLQQSYGIQ
                     SELVQAGSGFKQHTLRVKGDGPLWILLPALGNPSTSWSSTLRSVQGRHNAVALDLAGFG
                     LSESENDSPSYVDHVEYTLQYLETLEEKDWVLVANSAGSMIATEIARRHPDKVKALVCT
                     GFGLVEDVESWWGDLKKMSANPEQFLAAAYYHPPKMTPALEDLLNDVLSRPAYHAFLDE
                     YAKKSMATTFDNVTVPTLFVAGNHDQIIPPEWSEKAAEKLENATVTRLSRCGHFSASER
                     PEEFVWVVEDFLTKVDMA"
     aSDomain        2497..2682
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PL2TA16_01235_PP-binding.1"
                     /evalue="3.60E-08"
                     /label="PL2TA16_01235_PP-binding.1"
                     /locus_tag="PL2TA16_01235"
                     /protein_end="72"
                     /protein_start="10"
                     /score="25.7"
                     /tool="antismash"
                     /translation="QDLLEGAAPDLDQHTPLLELGILNSLSMVRLLAHVDQRYGAKIPE
                     HDITPVHFENIETLCAL"
     gene            3540..4760
                     /locus_tag="PL2TA16_01236"
     CDS             3540..4760
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 271.4; E-value: 2.6e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PL2TA16_01236"
                     /product="Dehydrogenases (flavoprotein)"
                     /protein_id="ESP90845.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-09, bitscore:
                     26.9, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Trp_halogenase (E-value: 2.1e-16,
                     bitscore: 49.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEFKSYDVVIIGSGPAGSLCGIECRKKGLSVLCIEKDEFPRFHI
                     GESLTGNAGQIIRDLGLAEEMDAAGFPDKPGVNVIGSLSKNEFFIPILAPTWQVKRSDF
                     DNMLKRKALEHGVEYQQGLVKDVIKHDGKVVGAIYKADDMEHQVRSKVLVDASGQNTFL
                     SRKGIAGKREIEFFSQQIASFAHYKGVERDLPPFSTNTTILYSKQYHWSWIIPISPDTD
                     SLGIVIPKDLYYKECKNPDDAIEWGMENISPEIRRRFQNAERIGDSQSMADFSYRIEPF
                     VGDGWLCIGDAHRFLDPIFSYGVSFAMKEGIRAADAIKQAIDGNDWKTPFYAYRDWSNG
                     GQQIAADLIRYFWIYPIFFGYQMQNPDLRDEVIRLLGGCCFDCEGWKAPTIFRNAIEEY
                     DRKQMVG"
     gene            4803..5945
                     /locus_tag="PL2TA16_01237"
     CDS             4803..5945
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 306.9; E-value:
                     3.4e-93)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PL2TA16_01237"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="ESP90846.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.2e-19, bitscore:
                     58.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 8.4e-22, bitscore:
                     66.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.6e-35, bitscore:
                     111.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFEWNEDQLELFEHALSFAQDLDFSKLPQGEFPMDAWRALGEFG
                     YFGLPIDSKYSPSGSGFDILTTVKVLEGLGQGCADTGILFAGAAHTFACAMPIYEHGSE
                     QLKQQLLPLLASGEKIAANAISEAEAGSNIAKLTTKAWREGDYYIIQGAKSYVTNGGVA
                     DYFVLYATTNAKFGYLGQTAFVVPADLPGIEVGNSYKKLGLNSAQLNQVFFDEVKVHKD
                     YVLGSEGQGARIFAASMDWERCCLFALFIGVMQRDLERCIDYANTRKQGDQTISKFQAV
                     SHRIADMEVRLQSARLLLYFAAWQKSQNVDNTKAVASSKLAISEAFVQSGIDSIRVHGA
                     LGYLQESGVDSSIRDALGSVLFSGTSDIQRELICNRLGLL"
     gene            5942..7498
                     /locus_tag="PL2TA16_01238"
     CDS             5942..7498
                     /NRPS_PKS="Domain: AMP-binding (17-418). E-value: 5.9e-90.
                     Score: 293.6. Matches aSDomain:
                     nrpspksdomains_PL2TA16_01238_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     290.2; E-value: 4e-88)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PL2TA16_01238"
                     /product="amino acid adenylation domain protein"
                     /protein_id="ESP90847.1"
                     /sec_met_domain="AMP-binding (E-value: 5.2e-102, bitscore:
                     330.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILSDVLHKGLCKGGDNALAVADNNESYSYGDLSLAVTQIAVLL
                     QSKGLKAGDRVGIWADKSCRALAAMLAVTKMGGVYVPIDPMNPMVRVDIIRTDCTMKAM
                     FTTQTKLAQYRDTRADDCLFVVLDSDGELSAAATQACELNSVCTWHDIEVCQPSRFKSD
                     SDVRAHDLAYMLYTSGSTGVPKGVRISHANALAFVQWVIDKIKPIASDRFSNHAPWHFD
                     LSVLDIYVALATGASVHLVSELDSYVPKKLVNFIAEREITIWYSVPTALTMMMNADPQF
                     GQKCKQLHTIIFAGEAFDTKSLSLLRAQFPLSDLFNFYGPTETNVCSYYKVPDSVPEEL
                     PIGYAASGARIAICDQQGNGVEIGERGFITVVGPTVFDGYWGKELRQQAAYNTGDIGYI
                     NEFGELMYIGRQDHMVKVKGYRVHLGEVERALYQHPEIKECLVELDENKNLIAHIACGS
                     QPPSLLTLKMHCAKRLPKYMLPEHVVYWDALPRNGNGKLSRRSLSETRPRHGSNTVQSG
                     A"
     aSDomain        5993..7195
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PL2TA16_01238_AMP-binding.1"
                     /evalue="5.90E-90"
                     /label="PL2TA16_01238_AMP-binding.1"
                     /locus_tag="PL2TA16_01238"
                     /protein_end="418"
                     /protein_start="17"
                     /score="293.6"
                     /tool="antismash"
                     /translation="NALAVADNNESYSYGDLSLAVTQIAVLLQSKGLKAGDRVGIWADK
                     SCRALAAMLAVTKMGGVYVPIDPMNPMVRVDIIRTDCTMKAMFTTQTKLAQYRDTRADD
                     CLFVVLDSDGELSAAATQACELNSVCTWHDIEVCQPSRFKSDSDVRAHDLAYMLYTSGS
                     TGVPKGVRISHANALAFVQWVIDKIKPIASDRFSNHAPWHFDLSVLDIYVALATGASVH
                     LVSELDSYVPKKLVNFIAEREITIWYSVPTALTMMMNADPQFGQKCKQLHTIIFAGEAF
                     DTKSLSLLRAQFPLSDLFNFYGPTETNVCSYYKVPDSVPEELPIGYAASGARIAICDQQ
                     GNGVEIGERGFITVVGPTVFDGYWGKELRQQAAYNTGDIGYINEFGELMYIGRQDHMVK
                     VK"
     CDS_motif       6152..6193
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PL2TA16_01238_0001"
                     /evalue="5.80E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="PL2TA16_01238"
                     /protein_end="84"
                     /protein_start="70"
                     /score="13.3"
                     /tool="antismash"
                     /translation="LAVTKMGGVYVPID"
     CDS_motif       6455..6514
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PL2TA16_01238_0002"
                     /evalue="1.20E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="PL2TA16_01238"
                     /protein_end="191"
                     /protein_start="171"
                     /score="30.2"
                     /tool="antismash"
                     /translation="AYMLYTSGSTGVPKGVRISH"
     CDS_motif       7160..7225
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PL2TA16_01238_0003"
                     /evalue="3.80E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="PL2TA16_01238"
                     /protein_end="428"
                     /protein_start="406"
                     /score="28.8"
                     /tool="antismash"
                     /translation="YIGRQDHMVKVKGYRVHLGEVE"
     gene            7610..9157
                     /locus_tag="PL2TA16_01239"
     CDS             7610..9157
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) PBDE:
                     FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 277.6; E-value: 3.9e-84)"
                     /gene_kind="biosynthetic"
                     /locus_tag="PL2TA16_01239"
                     /note="involved in K+ transport"
                     /product="putative flavoprotein"
                     /protein_id="ESP90848.1"
                     /sec_met_domain="FMO-like (E-value: 2.5e-83, bitscore:
                     269.6, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.4e-12, bitscore:
                     35.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTIAVIGAGLSGIAAVKQLTDGGHQVTCFEKAESFGGVFADKK
                     IYDDLHLTISNYFMAYSDYVPNHQKLKFWSKKEYINYLGEYIERFDIAKHIHYDHEVCC
                     VQKQGDKWLVTYKNADTEQTKEFDMVAVCSGHFQKPKLPDLPGLDMYQGNIEHSNDYRD
                     KHNYAGKRVLCVGLGESSADITSEISQVARKCILSLRRYPAVAPRYMAFQEDPYFTIDT
                     SWLTSRIVNKLPHRYHGGITKGIFNKYVTSRNDHVRIRGEWLKKSGPSHHQAVTKNERL
                     FRPIADGKVTPNIGGIERFEKNAVVFKDGTREEIDAVVFCTGYQLSFPFLDVSIANMRD
                     LYKQMFIPEMGHSLSFIGFVRPQQGGIPVIAEMQCRYLSKLASGEAQLPTLSEMHDVIK
                     YDTKHWQTEYKITPHVASLVNYCHYMDSVAKLVGCMPQIPSLFKDPMLRVKLLHNPQFA
                     AQYRLDGPNNMTHTAREFLLSFPNISSWPRIIHFEVALAAQKLLSRLRLDGLREISK"
     gene            9176..9784
                     /locus_tag="PL2TA16_01240"
     CDS             9176..9784
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) PBDE:
                     DUF98"
                     /gene_kind="biosynthetic"
                     /locus_tag="PL2TA16_01240"
                     /product="4-hydroxybenzoate synthetase (chorismate lyase)"
                     /protein_id="ESP90849.1"
                     /sec_met_domain="DUF98 (E-value: 1.5e-13, bitscore: 40.4,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRLSDESLCNLDDSLSTQAYNLSNLSYLQKIILGTDGTVTQLLE
                     SIVGEKIVVDKLLEAEVGVVPHEEEMHCQRRVITLNGDQTGLPYLYADSLVYHGNMNVN
                     FSRALTETRIPIGKAWEKFQIETYKTLLAWGFEYANELSQHFAIEPKDLVLYRTYLVYS
                     QGRKIFRITEKFPLAWYMQSEQFDNQFATPELSTLVSGI"
     gene            9788..11263
                     /locus_tag="PL2TA16_01241"
     CDS             9788..11263
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) PBDE:
                     p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 176.2; E-value: 1.9e-53)"
                     /gene_kind="biosynthetic"
                     /locus_tag="PL2TA16_01241"
                     /product="cytochrome P450"
                     /protein_id="ESP90850.1"
                     /sec_met_domain="p450 (E-value: 1.1e-74, bitscore: 241.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNTDTAEALPQSKLNLDELTPTIPHISFDSEDGQQFFWGEDFHL
                     IIESLSKKYGDIYSVETAKGPIVALNGYQYVREALVAQNDVFNVRADYEILQIAPQKHF
                     LELEAGEQWQVHRKVFANAMREYFSTRWDQIETWMTTEVNDIAAVWKAQGDVSFDPNRE
                     VSLKLASFLHKVMFDDRFGEFEVSIFDEKSLSWLPNGFINSTRHELMPTDLQERYYQQY
                     GDAIEKFSSNLNGLDQYVSFNVNRRKEDYVAGEYRDLCDYLFAANDSVDDATKAGLNIG
                     EKEIVVGSLTQVAGAGGGVGAFAMRWALLYLAAFPEYQARVQKELDEVVGDDEVPLNKH
                     KADLPYTQAFIAEVLRHCSITSMPAANYATSKDTLLDGYFIPEGTPLVINNYSITRDET
                     LWENPDEFIPERFLDDNGELSKKQQGKAFPFGLGQRRCLGELFGKYIIHTLFAQLAHKF
                     EFSIPEGKQVNLKAISGVFLVPEEVDIKAKSRL"
ORIGIN
        1 ctagcttggc tgtgtgagtt gggccagtgc ttgaaatagg tcaatgtcgg tattaagtaa
       61 tgtttctttg ggtatgggta actttagtgc aatgattttc tttgcggcca taaactcttt
      121 ggcgcaattg atgcaatctg cggcaatgac tttaccttgt ttgaggtacc acagtgacag
      181 tgcttgctcg ttgcattgac gtaaaatggt ttcgtcataa ccttgattaa gtccggcaat
      241 ttgaatttta caatcgaatt gatcagacca aaaccaaggc actgctgtga caggtttatg
      301 tttaccgcat atcgtcgcgg cggctgtttt tgcttgctct agagcattgg gcacggattc
      361 tatcctagtg gccaatccac tatgatgctc tatacctatt gtgcaatcgc ctgcggcata
      421 aatattgtta tctgtggttt gacagagttc attaatgaca attccgtcat tttcaattaa
      481 taaccctgca ctttttgcca gctcgacgtt ggttttagca ccaattccaa caaccacaat
      541 atcagcaggg atcactttgt cttcgcataa cacggtacta acggtgtctt tgccctgaaa
      601 agcaatgacg ttggtatcgg tgaatatttt tatgccattg cttttatgta gcttgtgata
      661 aaaggatgaa atactttgag ctgtcaccct agccaatagt cttgattccc gctcgataat
      721 agatacatca tggcccattt tcttaagcac cgcagccgtt tccaatccga tgtagcctcc
      781 accgaccatg acaattctac gtttattcgg tttccctttt tcggaattta ttgatgcgga
      841 tagcttttca atatctttga gggtttttat ataaaaaaca ttgttaagat cagctcccat
      901 gcagtccgct ttccttgcgc ggctgccagt acaaattaat aacttgtcgt aacttaggcg
      961 ctcgccggtt tgtaacacaa tactttgtat ggcgggctcg atacgctcaa cacgcgtatt
     1021 taattttact tcgacgtcgt cctttctata cgcatttagc ggccggataa gtaactgctg
     1081 ggcactgact ttgttttgta gataggtttt tgacagtggt gggcgatgat acggcaagct
     1141 gtcttcatcg gttagtaata tgatctgacc cgtccatcct tctcttcgta agctggtaca
     1201 cgcttgggcg cccgcatgac ctccaccgat aatgacacac ctttgcatct ttagctcctt
     1261 tagtattgcg attttggtaa gtggacttgc aagccatgat gttcatctga aaccataact
     1321 tggcagctta gcctacttag atcctttggc tcagcaacca attccaacat atcgctttca
     1381 ttgctgttgg gttcggcaat ttttccttgc caatcagtcg tcaagtaaca gtgacaagtg
     1441 gcgcagctac ctgagcctcc gcattcagct tcaatgccct cgaccatatt ttccatggca
     1501 gcttgcatca atgatgtgcc atttggtaca tctaccttgg tttcgttccc tgcaaaatct
     1561 ataaatgtaa tctcaggcat aatgttgtcc ttatacggta aatttagtga tctgatttat
     1621 ttcgtcgaga atggcagctg gatccgcttc aagttggcta tccatggcgg tgttccagcg
     1681 gttaaggaag ccacaaatgg caatcacagc agcaatttca attacagcct cttctgagta
     1741 atgtttgccc aatgtctcgt agtgtgattt ttcaaggtgt gcaggtgaag tactgcatgc
     1801 aaaagcaaag cgcagtgcag cacgttctgc gtcatcaaaa agcacgtttg tttcaaattc
     1861 aaatgccgcc aaaaccttag ctctattgac gtttacacga ctggcgatgt gagaaaagtg
     1921 gccttggcag tattggcacc ccgcagcatt actactgatg gttgcaattg cccatttaag
     1981 ctcgctgtta atgtgctcga atctactcaa acagccaaat agttgtccaa atgcttgtgc
     2041 aagcattggg tttttagcca tggtgagaat gccatttggg ataaacccaa gattgttttc
     2101 aatagcttga tagattggtt ccagatgtgg cgttgcagct ctttctactg gagttaccaa
     2161 atggttatta ccctgtttca tattcccttg tttcctaact tagtgatcat gccaacaaag
     2221 taagtttttt actcattgct gcctatagtc cgttcggacc aaagggatag tccactgggg
     2281 ctatgttgta aaaaactaga tagcgataga gtttttatag gcgaacgaat taagcacaag
     2341 cacacagtca aggttgcttg agttgagtgc caaaagaaaa tctgcctgat gatacgcaaa
     2401 accaaatttt ggttttgaat gttttttgag ggttaacaat attgccagac tagataggaa
     2461 actaggatga ttgaagaact tattgaattt ataaatcaag acttactaga aggggcggca
     2521 cccgatctag atcaacatac cccattactg gaacttggaa ttttaaactc tttatccatg
     2581 gtcaggctgc tcgctcatgt tgaccagcgt tatggtgcca aaatcccaga gcatgatatt
     2641 acgccagtac actttgaaaa tattgagacc ctatgcgctt taatcaaagt gttaagcact
     2701 gaggagcaaa gccagacaca agaagcaagc tctgagctag accgcttagt taaactgcag
     2761 caaagctacg gtattcaaag tgaattggtg caagcgggca gtggctttaa acagcataca
     2821 ttacgcgtca aaggagacgg tcctctgtgg attttgcttc cagcattagg taacccttcg
     2881 acgtcttggt cttctacact gcgctccgtt cagggacgtc acaacgctgt tgcacttgat
     2941 ttagcagggt ttggcctaag cgagagtgaa aacgactctc cttcatatgt tgaccacgta
     3001 gaatatacgt tgcaatatct tgaaacactg gaagaaaaag attgggtatt ggttgcgaac
     3061 tctgccggca gcatgattgc aacggaaatt gctaggcgcc accctgacaa agttaaagca
     3121 ttggtctgca ccggatttgg tttggttgaa gatgtagaga gctggtgggg agatttgaaa
     3181 aaaatgtctg ctaaccccga acagtttttg gccgcagcgt attaccatcc accaaaaatg
     3241 acaccagctt tggaagactt gctaaatgat gtgctgtctc gcccggcata tcacgccttc
     3301 ctagatgaat atgcgaaaaa gtcgatggca acgacatttg ataatgtcac tgttccgacc
     3361 ttgtttgttg caggaaacca cgaccaaatt attccacctg aatggagcga aaaagccgcc
     3421 gaaaaacttg aaaatgccac tgtcactcgg ttatctcgat gtggtcactt ttcggcatct
     3481 gagcgtccag aagagtttgt ctgggttgtt gaagacttct taactaaggt ggacatggca
     3541 tgagcgaatt taagagttac gatgtagtta ttattggcag tggtcctgct ggaagcttat
     3601 gtggcattga atgtcgtaaa aaaggtctgt cagttttatg cattgaaaaa gatgaatttc
     3661 cgcgcttcca tattggcgag tcgctgacag gaaacgctgg tcagatcatc agagacttag
     3721 gtctggcaga agaaatggat gcagctggtt ttcctgataa accgggtgta aatgttatcg
     3781 gatcattgtc taaaaacgag ttcttcattc caattttggc acctacttgg caagttaaac
     3841 gcagtgactt tgacaatatg ctcaagcgta aggcgttaga acatggtgtt gaataccaac
     3901 aaggcttagt taaggatgtg atcaagcatg acggcaaagt tgttggcgct atatacaaag
     3961 ctgatgatat ggaacaccaa gtgcgttcaa aagtgttggt cgatgccagt ggacaaaata
     4021 ccttcttatc gagaaagggc atcgcaggaa agcgtgagat tgagttcttt tcccagcaga
     4081 ttgcttcatt tgcacactat aagggggttg aacgtgattt gccgccgttt tcgacaaaca
     4141 ccaccatttt gtattcaaaa caataccact ggtcatggat cattcctatt tcaccagata
     4201 ctgacagctt agggatagtg atcccaaaag acctctacta caaagaatgt aaaaacccag
     4261 atgatgctat cgaatgggga atggaaaata ttagcccaga gatcagacgt cgcttccaaa
     4321 atgctgagcg tatcggtgat tctcagtcca tggctgactt ttcataccgc attgaaccct
     4381 ttgttggtga cggctggctg tgtattggtg atgcgcacag attcttggac ccaattttct
     4441 cttacggtgt gtcttttgct atgaaggagg ggatccgtgc tgcggatgca atcaagcaag
     4501 ccatcgatgg aaatgattgg aaaaccccat tttatgctta tcgagactgg agtaacggtg
     4561 ggcagcaaat tgcagcagat ttgatccgct acttctggat ctacccaatt ttctttggtt
     4621 atcagatgca aaaccctgat ctacgtgacg aagttattcg acttctgggt ggctgctgtt
     4681 ttgattgtga gggctggaaa gcgccaacaa tcttcagaaa tgccattgaa gagtacgatc
     4741 gcaagcaaat ggtagggtaa aggaaaagca ctgcgctttt ccttctaagg gaaggattga
     4801 ttatgaactt tgagtggaat gaggatcagc tcgagttgtt tgagcatgca ctgagctttg
     4861 cacaagactt agatttttct aagttgccgc agggggagtt cccaatggat gcatggcgtg
     4921 cgcttggcga gtttggctac tttggactac caatcgacag caagtattcg ccatctggga
     4981 gcggctttga cattttgaca acggtcaaag tcctagaagg cttgggtcaa ggctgcgcag
     5041 ataccggtat tttatttgcg ggtgcagcac acacgtttgc ctgtgcgatg ccgatttatg
     5101 agcatggcag tgaacaatta aaacagcagt tactgccttt attggcaagc ggagaaaaga
     5161 ttgctgccaa tgcgatttct gaagcagaag ctggttctaa catcgcaaag ttaacaacta
     5221 aggcatggcg tgagggtgat tattacatca ttcagggcgc gaagtcgtat gtgacaaacg
     5281 gcggtgtggc tgactacttt gtactgtatg ccactacgaa tgctaaattc ggttacctgg
     5341 gccaaaccgc ttttgtggtg cctgcggatt taccaggcat tgaagtaggg aatagctata
     5401 aaaaactggg cttaaactca gcgcaactta atcaagtttt tttcgatgaa gttaaagtgc
     5461 acaaagatta tgtacttggc agtgaggggc aaggtgcgag aatttttgcc gcgtcaatgg
     5521 actgggaacg ttgctgctta tttgctttat ttattggcgt gatgcagcgt gatttagagc
     5581 gctgtattga ctatgcaaat acgcgtaagc aaggtgatca aaccatcagc aaatttcaag
     5641 ctgtatctca ccgtattgcc gatatggaag tccgtctaca aagtgcccgt ttgctgctgt
     5701 actttgcagc ttggcaaaag tcacaaaatg ttgataacac caaagccgtt gcttcaagca
     5761 agcttgcgat cagtgaagct tttgtacagt cagggataga ctcgatccgt gtgcatggtg
     5821 ctctaggtta tctgcaagaa agtggtgtgg actcgagtat tcgcgacgca ttggggtcag
     5881 tgctgttttc agggacttca gacattcaac gagaacttat ctgtaatcgg ttgggcttgc
     5941 tatgaaaata ctcagtgatg ttttacacaa gggactctgc aaaggaggtg ataacgcact
     6001 ggcggtggcc gataataacg agtcatatag ctatggtgat ttatctcttg cagtgacaca
     6061 aatagccgta cttttgcaaa gcaaaggcct aaaagcgggt gatcgggttg gcatttgggc
     6121 tgataaatca tgtcgcgctt tagctgctat gttggccgtg accaagatgg gtggtgtata
     6181 tgtgcccatt gaccccatga accccatggt ccgtgttgat attattcgca ccgactgcac
     6241 gatgaaagca atgtttacga cccaaacgaa attagcgcaa tatcgcgata cacgtgctga
     6301 tgactgtctg tttgtcgtgc ttgatagtga tggggagctt agcgctgcgg caacacaagc
     6361 ctgtgaactg aattcagttt gcacttggca tgatatagaa gtttgtcagc cctcgaggtt
     6421 taaaagcgac tctgatgtgc gcgctcacga cttagcctac atgctttaca cctcgggctc
     6481 aacgggcgta ccaaaagggg ttcgtattag tcatgccaat gctttggcat ttgtacagtg
     6541 ggtgatcgac aagatcaaac ccattgcatc tgacaggttt tcaaatcatg cgccatggca
     6601 ctttgatttg tctgtactgg atatttacgt ggcattggca acaggtgcga gtgtgcacct
     6661 tgtctctgag ctggacagct atgtgcctaa aaagttagtt aattttattg ctgagcgaga
     6721 aattactatt tggtattcag tgccaacggc attaaccatg atgatgaatg cagaccctca
     6781 gtttggtcaa aagtgtaagc agcttcatac cattattttt gcaggtgaag cttttgacac
     6841 taagtcgctc tccttattgc gagcgcagtt tcccttaagt gacttattta atttttacgg
     6901 gccaactgaa accaatgtat gcagctacta caaagtacca gacagtgtac ctgaagaatt
     6961 acctatcggt tatgccgcaa gtggggctcg tatcgccatt tgtgatcaac aaggtaatgg
     7021 cgttgagata ggtgaaagag gatttataac tgtcgttggt ccaactgttt ttgatggcta
     7081 ttggggcaaa gagttacgcc agcaagcagc atataacacg ggtgatattg gttatatcaa
     7141 tgaatttgga gagttgatgt atatcggccg tcaagaccat atggtgaagg ttaaaggcta
     7201 cagagtgcat ttgggtgagg ttgaacgcgc cttgtatcag catcctgaaa taaaggaatg
     7261 tttggtagag ctggatgaaa ataaaaacct tatcgcgcac atcgcatgtg gctcccagcc
     7321 cccgtcattg ctgacgttaa aaatgcattg cgccaaacga ttgccgaaat acatgctacc
     7381 agaacatgtt gtttattggg atgcattacc acgcaatggt aacggcaaat tatcgcgtcg
     7441 aagcttatca gaaactcgcc cacggcacgg gagtaatact gtgcaaagtg gtgcgtaacc
     7501 agtttacaca aagtaaacat taacctcgga attgtacaaa tatcatatgg ctttatgcag
     7561 agccgttatg gctgtggtgt gcagttcctt gctatacacg gagagaatta tgaacaagac
     7621 aatagcagtg ataggtgctg gtttatctgg tattgccgcc gtcaaacagc taacagatgg
     7681 cggccatcaa gtaacttgtt ttgaaaaagc agaaagtttt ggaggtgttt tcgcagataa
     7741 aaaaatctat gacgacttac acctgactat ttcaaactat tttatggcct actcagacta
     7801 tgtgcccaac catcaaaagt tgaaattttg gtcaaaaaaa gagtatatca actacttggg
     7861 cgaatatatt gaacgttttg atatagctaa gcatattcat tatgaccatg aagtatgctg
     7921 tgttcaaaag caaggtgata aatggctcgt cacctacaag aatgccgata ccgaacaaac
     7981 aaaagagttt gatatggttg cagtttgctc aggacatttc caaaagccta agttaccaga
     8041 cttacctggt ttggatatgt atcaaggaaa cattgagcac tcgaatgatt atcgcgacaa
     8101 acataactat gctggcaaac gggtattatg tgttggctta ggcgaaagct cggcagacat
     8161 cacatcagaa atttcgcaag tggcgagaaa gtgtatttta tcgctgcgtc ggtatcctgc
     8221 ggtggcgcct cgatatatgg ctttccaaga agatccgtac ttcacaatag atacatcatg
     8281 gctcacatca cggatcgtaa ataaattacc gcatagatac cacggtggga tcaccaaggg
     8341 cattttcaat aagtatgtga cgagccgcaa cgaccatgtg cgtattcgcg gtgagtggct
     8401 gaaaaagtcc ggaccatctc atcatcaagc tgtgactaaa aatgaacgat tatttcgtcc
     8461 tattgccgac ggtaaggtta cgccaaatat tggtggtata gaacggtttg agaaaaatgc
     8521 agtagtattt aaagacggga cgcgtgaaga gattgatgcg gttgtctttt gcacaggtta
     8581 tcagctgagc ttcccgtttt tggatgtcag tattgccaac atgcgtgacc tctacaaaca
     8641 aatgtttata cctgaaatgg ggcattcact atcatttatt ggctttgtca ggccacaaca
     8701 aggcggcatt cctgttatcg cagagatgca atgccgttat ttgtccaagc tcgcaagtgg
     8761 tgaggcgcag ttgccaacac tatcagaaat gcatgacgtg attaagtacg atacgaaaca
     8821 ttggcaaact gagtacaaga tcacaccaca tgtcgcttct cttgtgaact attgtcacta
     8881 catggactca gtggcgaagc tggttggttg tatgcctcaa attcccagct tatttaaaga
     8941 ccctatgtta cgtgtaaagt tgttacacaa tccgcagttt gcagcccaat accgtcttga
     9001 tgggccaaat aacatgactc acacggcaag agaatttttg cttagctttc caaacataag
     9061 ttcctggccg cgaattattc attttgaagt ggcactggcc gcacagaaat tattgtctcg
     9121 cttgcgttta gacgggttac gcgagatcag caagtaaata gtacgaggaa aggacatgat
     9181 tcgattgtca gatgaaagcc tgtgcaattt agacgatagt ttaagcacgc aagcgtataa
     9241 cctgagtaac ctcagctacc tacaaaaaat tattctaggt actgatggaa ctgtaaccca
     9301 gctgctagaa agcattgttg gggaaaaaat tgtcgtcgac aaattgctcg aagcggaagt
     9361 tggagtagta ccacatgaag aagagatgca ttgccagcgg cgtgtgatca cgcttaatgg
     9421 tgaccaaact gggttgcctt atttgtatgc agactcttta gtgtaccacg gcaatatgaa
     9481 tgtgaatttt tctcgtgcat taactgaaac acgtattccc attggcaaag catgggaaaa
     9541 atttcaaata gaaacgtata agacattgct cgcttggggc tttgagtatg caaatgagct
     9601 gtctcagcat tttgccatag agcccaaaga tcttgtgttg taccgcactt acttagtgta
     9661 ttcacaaggt agaaaaattt ttcgcattac cgagaaattt ccacttgctt ggtacatgca
     9721 gtcagagcaa ttcgacaatc aatttgcaac accagaatta tcaaccttag tcagtgggat
     9781 ttgaccaatg aaaaacaccg atacagcaga agctttacca caaagcaaat taaatctaga
     9841 cgaattaact ccgacaattc ctcatatttc atttgacagt gaggatggac agcagttttt
     9901 ttggggtgag gattttcacc taataatcga atctctgtcg aaaaaatatg gagatatcta
     9961 ctcggtagaa acagccaagg gcccaatagt ggcgctgaat ggttatcaat atgtacgcga
    10021 agcattggtc gctcaaaacg atgtatttaa tgttcgagcg gactatgaaa ttttgcaaat
    10081 cgcaccacaa aagcactttt tagaattaga agccggagaa cagtggcagg tccaccgaaa
    10141 agtgtttgca aacgcaatgc gtgagtattt ttcaacccgt tgggaccaaa tcgaaacttg
    10201 gatgaccaca gaggttaacg acattgccgc cgtgtggaaa gcgcaaggag atgtatcatt
    10261 tgaccccaat cgcgaggtgt cgttaaagct cgccagtttt ttacataaag tcatgtttga
    10321 tgatcgcttt ggtgaatttg aagtgagtat cttcgatgaa aagagtctga gttggttgcc
    10381 caatggtttt ataaacagca cacgccatga attaatgcct acggatttac aagaaaggta
    10441 ctatcaacaa tatggtgatg cgatcgagaa gtttagctct aacctcaatg gtctagatca
    10501 atatgtttca tttaacgtga atcgccgtaa agaagactat gtggccgggg agtatcgcga
    10561 tttatgtgat tatttgttcg cagcgaatga tagtgttgat gatgcgacta aagcgggctt
    10621 aaatatcgga gaaaaagaaa ttgtcgtagg atctttaacc caagttgcgg gtgctggcgg
    10681 tggcgttggg gcattcgcga tgcgctgggc cttgttatat cttgccgctt tccctgaata
    10741 ccaagcgcgt gtgcaaaagg agctagatga agttgttggg gatgatgagg taccgctcaa
    10801 taagcacaaa gctgacttac cttatacaca agcatttatc gctgaagtgc tacgtcactg
    10861 ttctattacg tctatgccag cggcgaatta tgcaactagc aaagatactt tgttagacgg
    10921 ttattttatt ccagaaggca cgccgctggt gattaataat tacagtatta cccgtgacga
    10981 gacgctgtgg gaaaacccag atgaatttat ccccgagcgt tttttagatg acaatggtga
    11041 actgagtaaa aagcaacagg gcaaggcatt tccatttggt ctaggtcagc gtcgttgttt
    11101 gggggagcta tttggtaagt atattattca cactttattt gctcagttgg cacataagtt
    11161 tgaattttct atacccgaag gtaaacaggt aaatctaaaa gcaatttctg gcgtattttt
    11221 agtacctgaa gaagtggata ttaaagctaa atcgagatta tag
//
