Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000891.1:
Cluster 1Other111263

BGC0000891, bromophenols / bromopyrroles biosynthetic gene cluster from Pseudoalteromonas luteoviolacea. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: pentabromopseudilin
SMILES string: Copy to clipboard
Molecular formula: C10H4Br5NO
Exact molecular mass: 547.61 Da (None)
Molecular activity: Antibacterial, Cytotoxic, Inhibitor
Molecular target: myosin ATPase, IspD

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Aminocoumarin

Gene cluster description

bromophenols / bromopyrroles (BGC0000891). Gene Cluster 1. Biosynthetic class = Other. GenBank AUSV01000133, positions 32483-43745. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Prof. Bradley S. Moore (Scripps Institution of Oceanography, UCSD)

Literature references

1. Agarwal V et al. (2014) Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. Nat Chem Biol 10(8):640-7. doi: 10.1038/nchembio.1564. Epub 2014 Jun
2. Fedorov R et al. (2009) The mechanism of pentabromopseudilin inhibition of myosin motor activity. Nat Struct Mol Biol 16(1):80-8. doi: 10.1038/nsmb.1542. Epub 2009 Jan
3. Kunfermann A et al. (2014) Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD. Angew Chem Int Ed Engl 53(8):2235-9. doi: 10.1002/anie.201309557.
4. Laatsch H et al. (1995) Structure-activity relationships of phenyl- and benzoylpyrroles. Chem Pharm Bull (Tokyo) 43(4):537-46.