Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000892.1:
Cluster 1Other113187

BGC0000892, caryoynencin biosynthetic gene cluster from Burkholderia gladioli. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Caryoynencin
PubChem ID: 6474912
ChemSpider ID: 4976794
SMILES string: Copy to clipboard
Molecular formula: C18H16O3
Average molecular mass: 280.323 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
None

Gene cluster description

caryoynencin (BGC0000892). Gene Cluster 1. Biosynthetic class = Other. GenBank CP002599. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Proven expression in natural host, Sequence-based prediction
MIxS-compliance:Unknown
Comments:The experimental validation of function and structure was done in Burkholderia caryophylli strain DSM 50341, not in Burkholderia gladioli BSR3. The accession numbers of the experimentally targeted genes are: KJ815051, KJ815052, KJ815053, KJ815054, KJ815055, KJ815056, KJ815057, KJ815058, KJ815059, KJ815060.
Contact for this cluster:Keishi Ishida (Leibniz Institute for Natural Product Research and Infection Biology)

Literature references

1. Ross C et al. (2014) The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria. Angew Chem Int Ed Engl 53(30):7794-8. doi: 10.1002/anie.201403344.
2. Fritsche K et al. (2014) Biosynthetic genes and activity spectrum of antifungal polyynes from Collimonas fungivorans Ter331. Environ Microbiol 16(5):1334-45. doi: 10.1111/1462-2920.12440. Epub
3. Yamaguchi M et al. (1995) Chemistry and antimicrobial activity of caryoynencins analogs. J Med Chem 38(26):5015-22.