BGC0000893 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000893 (Streptomyces venezuelae ATCC 10712)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	22,006	chloramphenicol	NRPS:Type I	100%

BGC0000893 - Region 1 - NRPS-like

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Location: 1 - 22,006 nt. (total: 22,006 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 22,007
Label		BGC0000893

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000893	1.00	NRP	chloramphenicol	Streptomyces venezuelae ATCC 10712
BGC0002341	0.34	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000840	0.27	Other	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000131	0.24	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002474	0.22	NRP	agrobactin	Agrobacterium tumefaciens
BGC0002069	0.21	Other (Aminocoumarin)	styrolide A, styrolide B	Pseudomonas fluorescens
BGC0001366	0.21	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002443	0.21	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0001909	0.21	Polyketide	strobilurin A	Strobilurus tenacellus
BGC0002347	0.19	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000893	1.00	NRP	chloramphenicol	Streptomyces venezuelae ATCC 10712
BGC0002341	0.67	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000840	0.60	Other	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000131	0.57	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002474	0.55	NRP	agrobactin	Agrobacterium tumefaciens
BGC0002069	0.54	Other (Aminocoumarin)	styrolide A, styrolide B	Pseudomonas fluorescens
BGC0001366	0.54	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002443	0.54	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0001909	0.53	Polyketide	strobilurin A	Strobilurus tenacellus
BGC0002347	0.51	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 22006:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SVEN_0922

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AMP-binding (12..392): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASMECAVCK
Nearest Stachelhaus code(s):: Tyr DASTIAAVCK (74% 8Å match)
Stachelhaus code match:: 70% (weak)

SVEN_0927

AMP-binding (10..384): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IGNPTGTIAK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (59% 8Å match)
Stachelhaus code match:: 90% (moderate)