LOCUS       BGC0000897             20143 bp    DNA     linear   BCT 24-JUL-2016
DEFINITION  Streptomyces luridus strain NRRL 1510 putative transglycosylase
            gene, complete cds; and dehydrophos biosynthetic gene cluster,
            partial sequence.
ACCESSION   BGC0000897
VERSION     BGC0000897
KEYWORDS    .
SOURCE      Streptomyces luridus
  ORGANISM  Streptomyces luridus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:23:48
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..507
                     /codon_start=1
                     /note="Orf5"
                     /product="putative transglycosylase"
                     /protein_id="ACZ13451.1"
                     /transl_table=11
                     /translation="MRRRHRAPAGRSAAHGRSAGGMRNQHEGGCLRPRPAGTRRAAKVT
                     AVNGRSPRVVSVGHHCGSHHRPAGQARPTRAAAHPPLADGPAGYRRRCRRQCARQCVRC
                     ARHRWYRLDPPRVPDRHRRRPHRLRHPHVGPTARLTSPPAPQPRRSPGTGGAAVCHAPA
                     TSREN"
     source          1..20143
                     /clone="cosmid 17E11-4"
                     /db_xref="taxon:67320"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces luridus"
                     /strain="NRRL 1510"
     subregion       1..20143
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000897"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20143
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..15359
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3857:10359]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3858..10359
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..15359
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     misc_feature    91..93
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            607..1506
                     /gene="dhpA"
     CDS             607..1506
                     /NRPS_PKS="Domain: TauD (38-290). E-value: 2.8e-26. Score:
                     84.7. Matches aSDomain: nrpspksdomains_dhpA_TauD.1"
                     /codon_start=1
                     /function="responsible for hydroxylation of
                     2-hydroxyethylphosphonate to form
                     1,2-dihydroxyethylphosphonate"
                     /gene="dhpA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /note="DhpA"
                     /product="2-ketoglutarate dependent dioxygenase"
                     /protein_id="ACZ13452.1"
                     /sec_met_domain="TauD (E-value: 8.6e-27, bitscore: 84.7,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGGGHQTTPGQTLTDGFDAVRVAVAGPLRDHLTSAGESTADAGA
                     ARAELAALVGEHLDDGPGVLVLTGLPADREGGERAVLRATRLLGEPLPQNREGTLVREV
                     RDRGMSISQRGRTRYSDSRFGGDLHTDGAEAPLPAPDVFTLFCVRQSVHGGALQCLHVR
                     EVERALDPEVLATLRAPFRFDRRGDQEPGQDPTTAKPVLFSQRGRPAITYLRSYIEHGH
                     DHPGVPALTTGQRAALDALDALIASSPAVLTGKLREGELALFDNLSLLHGRTEFQDEPD
                     HTRLLLRTWVRRHSDERS"
     misc_feature    607..>20143
                     /note="dehydrophos biosynthetic gene cluster"
     aSDomain        721..1476
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_dhpA_TauD.1"
                     /evalue="2.80E-26"
                     /label="dhpA_TauD.1"
                     /locus_tag="dhpA"
                     /protein_end="290"
                     /protein_start="38"
                     /score="84.7"
                     /tool="antismash"
                     /translation="STADAGAARAELAALVGEHLDDGPGVLVLTGLPADREGGERAVLR
                     ATRLLGEPLPQNREGTLVREVRDRGMSISQRGRTRYSDSRFGGDLHTDGAEAPLPAPDV
                     FTLFCVRQSVHGGALQCLHVREVERALDPEVLATLRAPFRFDRRGDQEPGQDPTTAKPV
                     LFSQRGRPAITYLRSYIEHGHDHPGVPALTTGQRAALDALDALIASSPAVLTGKLREGE
                     LALFDNLSLLHGRTEFQDEPDHTRLLLRTW"
     gene            1503..2654
                     /gene="dhpB"
     CDS             1503..2654
                     /codon_start=1
                     /gene="dhpB"
                     /note="DhpB"
                     /product="1,2-dihydroxyethylphosphonate kinase"
                     /protein_id="ACZ13453.1"
                     /transl_table=11
                     /translation="MNRGPAPAAEIVVAPNCMRGYASAAEVAAALITGVRRVRPRVRAV
                     ARPLADGGDGTLDALYAACGGVRHPVAAVDVLGRTRKAHWLALDRRTAAVETAGVCGLG
                     ALRPRELRPLRATSAGAGQAVAAAVEAGATTVLVGLGGTAVVDGGAGALAALGARFLDR
                     DGHEVEPVPERLPDAVRVDLSAARRLLEGVTVRLLADVRTPLSGNLDSFGAQKGVTAEN
                     RPAAVRALQHLTSLLGQAGDLTAADRFRTPWFGAGGGIGFGLSAVAATTAESGTEALLD
                     ITDPGGSISTAALVITAEGAIDPGTWQGKLPGTIARLRRDRGLPTAMVAARAEADAATA
                     DPLVTVHLAADPPLDAPLVGPALHEGLARAAAAACRTWAVAAA"
     gene            2746..3861
                     /gene="dhpC"
     CDS             2746..3861
                     /codon_start=1
                     /gene="dhpC"
                     /note="DhpC"
                     /product="1-hydroxy-2-phosphorylethylphosphonate
                     dehydrogenase"
                     /protein_id="ACZ13454.1"
                     /transl_table=11
                     /translation="MYASDGTDRASVVGRKPLTDFVIEALTSVGAGEADAALTADVLVA
                     ADLAGVDSHGVARLRRYVEGLRNGTINGRARPRVEREHGGVSVVDAQNGLGQPALCFAV
                     DLAVERAREHGVAAVAVRRSNHIGIAGWYTERAARSGTFAMVTTNATPQVAPTGAAEPM
                     FGTDPVSYAVPTAGEPLCYDAATSIVPRGKLERLDREGKPMLPGWAVGPDGATSTDIPR
                     VVAGLKAREGYALLPVGGLGEEYGGHKGSGIGLLAELLCGPLTGASWSKHTYGPEGADL
                     GQFVLCLDLAALGDAGRITRDVDAMAAEIRAARRADEDVPVRLPGERRHRCAEERSARG
                     IPLLPPVVRDLGKIAELTGIKPLGARDGQDA"
     gene            3858..5051
                     /gene="dhpD"
     CDS             3858..5051
                     /NRPS_PKS="Domain: Aminotran_1_2 (22-382). E-value:
                     1.4e-53. Score: 174.2. Matches aSDomain:
                     nrpspksdomains_dhpD_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="dhpD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 224.2; E-value:
                     4.4e-68)"
                     /gene_kind="biosynthetic"
                     /note="DhpD"
                     /product="predicted aspartate transaminase"
                     /protein_id="ACZ13455.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.3e-54, bitscore:
                     174.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4.2e-12,
                     bitscore: 36.1, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSARGSSPAPSLAVREDTGPPVIDLSSGQILEPLPEAARAAIR
                     RATESPEASGYAPGPGRADLRTAVADHYARRTGAATDPDHVTVTAGARHGLFAAVAAAA
                     AGREVLVPAPHWSHYPTVIRQAGAVPVTVAGDPLHGLLVDPARLDAAWTPRTGAVLVNS
                     PVNPSGACYDEGRLRELRAWAAARNVRLIVDDIYWAYGSHIDTRLLPGPHEVVVGGASK
                     VYALAGLRIGWVWAEPALGAAVREIVEHTTGPVSGPAQAAAAAVLAYENGTGGTGAAVA
                     GAGVARRADRLARQRAEAVQAMAAVPYLRPVPPAGGIYLCLDASEALGLRLLGAGDDQE
                     LCRALRSGAGVGLRAGSTFGMPGFLRLCVAESHEVLLTAAHRLTTCLTAAAREVTHH"
     aSDomain        3924..5003
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_dhpD_Aminotran_1_2.1"
                     /evalue="1.40E-53"
                     /label="dhpD_Aminotran_1_2.1"
                     /locus_tag="dhpD"
                     /protein_end="382"
                     /protein_start="22"
                     /score="174.2"
                     /tool="antismash"
                     /translation="PVIDLSSGQILEPLPEAARAAIRRATESPEASGYAPGPGRADLRT
                     AVADHYARRTGAATDPDHVTVTAGARHGLFAAVAAAAAGREVLVPAPHWSHYPTVIRQA
                     GAVPVTVAGDPLHGLLVDPARLDAAWTPRTGAVLVNSPVNPSGACYDEGRLRELRAWAA
                     ARNVRLIVDDIYWAYGSHIDTRLLPGPHEVVVGGASKVYALAGLRIGWVWAEPALGAAV
                     REIVEHTTGPVSGPAQAAAAAVLAYENGTGGTGAAVAGAGVARRADRLARQRAEAVQAM
                     AAVPYLRPVPPAGGIYLCLDASEALGLRLLGAGDDQELCRALRSGAGVGLRAGSTFGMP
                     GFLRLCVAESHEVLLTAAHR"
     gene            5062..5952
                     /gene="dhpE"
     CDS             5062..5952
                     /codon_start=1
                     /gene="dhpE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 252.6;
                     E-value: 8e-77)"
                     /gene_kind="biosynthetic"
                     /note="DhpE"
                     /product="phosphoenolpyruvate phosphomutase"
                     /protein_id="ACZ13456.1"
                     /sec_met_domain="phosphonates (E-value: 1.4e-102, bitscore:
                     332.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 5.9e-129,
                     bitscore: 419.0, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.5e-64, bitscore:
                     205.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIASYGPSTLPGSRAATLRDAFANGRLVRVAGAHDGLSARLAEE
                     AGFDSVWASGLEISAAHGLPDVSLLGMAEYLSAAVAMQRSVSVPVVADCDTGFGGVLNA
                     AYTMMRYEEAGVAGVCIEDKIFPKRNSFVNSGQKLLDVDEFGRKLEAAKRAQVSSDTVL
                     IARTEAFICGLGLQEALTRCHHYVDAGADAVLVHSKAVDSGEVVSFMKEWNHRAPVVVV
                     PTTYADFSAAEAQEAGISMVIYANQGMRAAITAIRSTWATVLAEGSTAPVEPRIASVKD
                     IFAISGMDQWLDLDR"
     gene            5949..7094
                     /gene="dhpF"
     CDS             5949..7094
                     /codon_start=1
                     /gene="dhpF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 64.4;
                     E-value: 1.4e-19)"
                     /gene_kind="biosynthetic"
                     /note="DhpF"
                     /product="phosphonopyruvate decarboxylase"
                     /protein_id="ACZ13457.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-10, bitscore:
                     31.3, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.4e-20, bitscore:
                     62.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDRITAEEFVAALRAHGVQRVTGVPCGHLAGPWALFDGAGDLTP
                     AASEGAALALAAGWELAGRTSVVLCQNSGFGNLVNPLTSLLLPYRVPVLVVMTMRGWPD
                     PAEDEPQHAAMGTSTVALLETLDVPHAVLWPGKLEEALGQAADARAAGRPFFLLVPRGA
                     IGKAAGAYPAGAPADDRLTRPRAVAALMAELTDELMVTTTGYLSRQAHHERDRPDTFYM
                     QGSMGHASAVGLGLATARPERRTVVLDGDGAFLMHLGSGSTIGSSGARNLTHVVVDNGC
                     YESTGCQPTTSGGLDWASLGTGLGYRTVLTCDSTGDLTGSLRAALTAEGPVLLALTVVP
                     TPGEVHPRATASLGPELIAGRFREAAAAAAGGGAPEPERLP"
     gene            7091..8281
                     /gene="dhpG"
     CDS             7091..8281
                     /codon_start=1
                     /gene="dhpG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /note="DhpG"
                     /product="alcohol dehydrogenase"
                     /protein_id="ACZ13458.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.9e-67, bitscore: 217.7,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPLARGSGPRRDTVLLTGRGSFGRVPGLSEGRRVLVVASSRAL
                     LRAPVAAWLPPDAVTFTAFHPNPTVAQGVEAARLRRASGADLVVGIGGGSALDVAKAAR
                     VLPGDAGAADEVIAGRRPVPEGVPELLLVPTTAGTGSEVTQFATLYRGHRKVSLDTPAA
                     RADVAVVDPELTETCPADLTWTCAFDTLAHAVESLWSVRSTAESREHAVAALRSSLPVL
                     RCAGDLPSPAERDALSRAATLAGQAIDLTRTTAAHALSYPLTAHLGIPHGLACALNLAW
                     LAPLVEAAGPERVTDPRGHAAVREAVGTLRELFGADEQGTDLAGALRALLARRASFPYA
                     GAPDAPYDLLVAEGLSSDRMSGMPVRLERHEARAGLETVLGAGTERKRGTTCATTG"
     gene            8263..10359
                     /gene="dhpH"
     CDS             8263..10359
                     /NRPS_PKS="Domain: Aminotran_5 (17-320). E-value: 5e-38.
                     Score: 122.8. Matches aSDomain:
                     nrpspksdomains_dhpH_Aminotran_5.1"
                     /codon_start=1
                     /gene="dhpH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 85.8; E-value:
                     4.6e-26)"
                     /gene_kind="biosynthetic"
                     /note="DhpH"
                     /product="aminotransferase/oxidoreductase"
                     /protein_id="ACZ13459.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.9e-29, bitscore:
                     92.2, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.1e-08, bitscore:
                     22.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNYRVTGPVEVPDGTLAAMTTRMISHRSDGFRDLFGGIAPRLGA
                     LFGTAGTVLPLTCSGTGGLEAVAASLLRPGDRVLSVQLGYFGERFAEIAEHHGAVVDVL
                     AAPWGQVVDTALITERLAAGYDAVLLTHNETSTGVVAPLRAWAQAIRAVSDCLILVDVV
                     SSLAAVEIGFDELGLDAAVGVTQKALACPPGLSLVAVSERALARAAEPGEGSYYLSLAR
                     AAEHARAGTTTYTPALSVLYALDTALAAIEKEGVEAVWERHARTARRCRDALRARGLVV
                     VPDEAHSSPTVTAVRLPAGGAVRVREALAAEHDTWVSSGRGPWKDEVLRIGHMGPVEPA
                     GVDACAAAIAACLDGSAGGPAAGAPPAAGAALDVRGTDGADGLGPDWDGLVARLDAPVF
                     HTRAFLRAYEHHPVQRISEPRYLEVRRDGELVAAAPTYLQGDPLGLLGMADGEQALLSP
                     MWHSPDSRLLAADEDALDALTRAFAARAAELDAPQWGFANLGTDHPLVRALERKGFRRR
                     ELVPRWTLHRSDAPDGDAYLAGMRRSVRRDYQRQLRRYREQGHARVHRADHEGLVPLLE
                     LIAASATRTGSPKYYDPLKLAAFLRELDEPVRVVEVRENDGEPLAVAVCFLEDKRLQAW
                     AGGYVRGRADLRFSPYYALWWEIVELMWSAGTESIECGRLNESFKEKMLLRPQHLVAML
                     GPSL"
     aSDomain        8314..9222
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_dhpH_Aminotran_5.1"
                     /evalue="5.00E-38"
                     /label="dhpH_Aminotran_5.1"
                     /locus_tag="dhpH"
                     /protein_end="320"
                     /protein_start="17"
                     /score="122.8"
                     /tool="antismash"
                     /translation="AAMTTRMISHRSDGFRDLFGGIAPRLGALFGTAGTVLPLTCSGTG
                     GLEAVAASLLRPGDRVLSVQLGYFGERFAEIAEHHGAVVDVLAAPWGQVVDTALITERL
                     AAGYDAVLLTHNETSTGVVAPLRAWAQAIRAVSDCLILVDVVSSLAAVEIGFDELGLDA
                     AVGVTQKALACPPGLSLVAVSERALARAAEPGEGSYYLSLARAAEHARAGTTTYTPALS
                     VLYALDTALAAIEKEGVEAVWERHARTARRCRDALRARGLVVVPDEAHSSPTVTAVRLP
                     AGGAVRVREALAAEHDTWVSSG"
     gene            10400..11056
                     /gene="dhpI"
     CDS             10400..11056
                     /codon_start=1
                     /gene="dhpI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 63.7; E-value:
                     3.1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /note="DhpI"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="ACZ13460.1"
                     /transl_table=11
                     /translation="MTTSHGLIESQLSYYRARASEYDATFVPYMDSAAPAALERLRAGN
                     IRGDVLELASGTGYWTRHLSGLADRVTALDGSAEMIAEAGRHGLDNVEFRQQDLFDWTP
                     DRQWDAVFFAHWLAHVPDDRFEAFWESVRSAVAPGGVVEFVDVTDHERRLEQQDDSEPE
                     VAVRRTLQDGRSFRIVKVFRSPAELTERLTALGWSCSVDEVHPGFLYATCRPGPR"
     gene            11112..11804
                     /gene="dhpJ"
     CDS             11112..11804
                     /codon_start=1
                     /gene="dhpJ"
                     /note="DhpJ"
                     /product="predicted peptide aspartate dioxygenase"
                     /protein_id="ACZ13461.1"
                     /transl_table=11
                     /translation="MNGSLSINQPGVRKAINRYFLKASGGRNRFRIMSPYALFPESRKL
                     DYQFDQIKAEVTKLVETRDVRPYGDIDPLRAAEVSTDWRLYYAYMLGETNPAAYRDCPT
                     FVDFAERTPRVVNAIIAILEPGVTLKAHEGPYAGILRYHLPLTVPENNPPRLRVDQEMH
                     TWQEGQGILIDDTFEHEVYNESDGRRVMLIIDIRRPMGLVPDVVNRLSLRAKRKWSAQF
                     IKESGGDI"
     gene            11878..13146
                     /gene="dhpK"
     CDS             11878..13146
                     /codon_start=1
                     /gene="dhpK"
                     /note="DhpK"
                     /product="hypothetical protein"
                     /protein_id="ACZ13462.1"
                     /transl_table=11
                     /translation="MTEGMPVSEVRILSSVDEVGPAAWEELTKAADVDSSHGFLRFREY
                     VEPGRSVLFTLGPPERPRGALRGVVAVPGSGLTSDPWKFVGSQAVLRLDAGTDEAEAAS
                     LRRAQRDLVRAAADPAGRAGDDGGEPLWQALTRGLGACLVVREFDRSELLCHPEADAAE
                     ARSVAARLVRAAQTSAAEHGAGAVAFPFVSPRDTLLRSVLTEAGFRGGAMTGASWVETG
                     GYGSYEEFLAVLPSRRRRRYRLEEQRLLEAPDLTTAEVDPVRNAARIAELEARTLVKHG
                     GLADAEAIRRARIELADRLPDDAVVIPAVIRDGRIIACALHLRGPRSVVFMTYGCDYDV
                     EERGPAYPWAAFYHPIRTAIAHGASSVRLGLEGFEAKTRRGAVVEARELWVWTPDAAAL
                     ARLGDLLELVGERNTSYLGRFSQ"
     gene            13202..14470
                     /gene="dhpL"
     CDS             13202..14470
                     /codon_start=1
                     /gene="dhpL"
                     /gene_functions="transport (smcogs) SMCOG1184:major
                     facilitator transporter (Score: 296.3; E-value: 4.3e-90)"
                     /gene_kind="transport"
                     /note="DhpL"
                     /product="putative integral membrane transporter protein"
                     /protein_id="ACZ13463.1"
                     /transl_table=11
                     /translation="MTAGETAEEIQDPAAEDGGGPDRLLLSALAVGAFAIGTDSLVISG
                     LLNRIASDLSVSPATTGQLISVFALVYAVGAPVLATVTAGFDRRRLLLVALTVFIAANV
                     LGAVAPNYPVLLASRVLAAVGAGLYLPCAMVITVSVTPERWRGRGLAMVAGGMSAATAL
                     GVPLGTLIGAVGDWRATLVLVAVLATVAVAVLAKAVPRVAAPAAVTLGQRLRSAAHPQV
                     LIALLANALACAGEFTVMVYVAPLAEDVTGVGAAGVSAFLLVSGLAALAGSAVGGRAAD
                     RFGGRRAYNGAVAVLFGGLAALVLLTLADGRGSWVTAGVFALLLCVVSVASWALPPAQN
                     HAIAGLDIPEPTVALSLNGSSSYLGLAMGGVLGGLAMEHGSSTTLTAAGAAVELSALAL
                     LLTTAVVTAKRRRATAPGPRPGK"
     gene            complement(14406..15917)
                     /gene="dhpM"
     CDS             complement(14406..15917)
                     /codon_start=1
                     /gene="dhpM"
                     /note="DhpM"
                     /product="putative sodium/solute symporter"
                     /protein_id="ACZ13464.1"
                     /transl_table=11
                     /translation="MTVGPMAATLMAVIGGSSLLAVTARRLNPSSDLPSLGGWALADRS
                     LGTGWTWLLLGGSIFTSYTFTAVPGLVYGNGAPAFFALPYTIIVCPLAFVLLPRMWAVA
                     RKHGHVTAADFVRRRYDSAPLALVVALTGILATMPYLALQLLGIRAVLDAAGVPSRAAV
                     GDCVMIAIFAGLAIATYRHGLRAPAVISALKGVAVFGSAVAVCWLVLDRMNGPEGVFAA
                     AATRLSDSTANASLVLTPGQQPAFVTLAIGSALALLMYPHVLTAAFAASDAAVLRRVSI
                     ALPLWTVVLALFGLLGIAAIAMGVDTPENGAEAAVPMLTALLMPGPLVGLVFGAITVGA
                     LVPAAVMSIAAATSFVRNVYVEYVHPTATPKRQVRIARTVSLTAKLGAVVFVFGLRDQD
                     AINLQLLGGVWILQIFPAVAVGLYTARLRPAALLAGWSAGMLLGTALVVRGGFSAVVPL
                     GIPGSAGVYVGLVALLLNLVISLFLTFLAEARERWPGAASPSPRP"
     gene            16427..17989
                     /gene="dhpN"
     CDS             16427..17989
                     /codon_start=1
                     /gene="dhpN"
                     /note="DhpN"
                     /product="putative sodium/solute symporter"
                     /protein_id="ACZ13465.1"
                     /transl_table=11
                     /translation="MREEALLAAFLSVVGATSLWAVSARRFHARDTLPSLEGWALADRS
                     LGTLWTWLLLGGTVFTAYTFAAVPGLVYGDGASGFFALPYTVIVWPLAFVLLPRLWAMA
                     RAHGHITVADVVRGRYGSPSLALAVALTGILATLPYLALQLVGLRAVLTVSGLYPRGPT
                     GDLALIALFAVPALASYRYGLRAPTVISALKGILVFCSAFAVMALVLGRLGGPGPMFDA
                     AALHLAERAAPDAALVPGPHQQGAYATLALGSALALLMYPHVLTAGFAASSAGTLRRAS
                     VALPAWTAVLALFGLLGVAALAAGIHTPPGRAEEAVPLLVGSFLPALLAGLVLGALAVG
                     ALVPAAVMSIAAASLFVRNVYVEYVQPTATPKRQVRIARVVSLVVKVAAVAFAVGLRDQ
                     DAINLQLLGGVWILQVFPAVAGGLLTRRLHERALLAGWGTGMVAGTTLVVGHGFSSVVP
                     LPFGGRELEVYTGLAAFLLNVAVAVVLTTVFDRLGPPRGAATTALPQRPAAGRRTTRGT
                     SSP"
     misc_feature    16481..16483
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17986..18609
                     /gene="dhpO"
     CDS             17986..18609
                     /codon_start=1
                     /gene="dhpO"
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 102.8;
                     E-value: 2.6e-31)"
                     /gene_kind="regulatory"
                     /note="DhpO"
                     /product="putative sigma-24"
                     /protein_id="ACZ13466.1"
                     /transl_table=11
                     /translation="MKRTRQDVISSLPSTATRRALGEGDAPGAAQAPLVDLAELEREAG
                     LSRLFDLHYASMLRLATLLGADDPENIVAEAYYQIYRKWRKLRDSSSAEAYLRSVVCNL
                     TRMRIRHLQVVRKHVETPDASVVPTEASAASAEASALLRDDQRVLVAALRKLPTRQREA
                     LVLRHWLGLKESEIAEAMGISCGSVKTHTARGIAALTQAMEARR"
     gene            19127..>20143
                     /gene="dhpP"
     CDS             19127..>20143
                     /codon_start=1
                     /gene="dhpP"
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 297.2; E-value: 2.6e-90)"
                     /gene_kind="regulatory"
                     /note="DhpP"
                     /product="putative lacI family regulator"
                     /protein_id="ACZ13467.1"
                     /transl_table=11
                     /translation="MKRPTIADIARHAGVSKVAVSYALNDRPGVSDATRTSIKAIAEEL
                     GWRPNSAARALNGACAQAVGLVVRRPPSTLGVEPFFMELVSGIGSVLSAQSYALMLQMA
                     DSHEQELEVHRRWWGERRVDGVFLVDLHSDDARVPAVEALGLPVVAIAPPGTSGSLPAV
                     WSDDGESVREAVRYLAALGHRRIARVAGPAELAHTAVRDLALREACAEAGLPEPETVHT
                     DYTGEEGARATRHLLIAARRPTAMVFDNDIMAVAALSVAQELGLDIPADLSLVAWDESP
                     LTQVVRPPLSAVARDIPAYGATAARSLLALIAGESVGDVRGAPGRLVPRGSTRPPRTA"
ORIGIN
        1 gtgcgtcgac ggcaccgggc gccggcgggg cggagcgccg cgcacgggcg ctcagcgggc
       61 gggatgcgga atcaacatga aggcggatgc ttacggccgc gtccggcggg cacgcggagg
      121 gcagcgaagg tcacggcagt gaacggaagg agtcctcgtg tcgtttctgt gggccatcat
      181 tgcgggtctc atcatcggcc tgctggccaa gctcgtccta cccgggcggc agcccatccc
      241 cctctggctg acggtcctgc tgggtatcgt cggcgctgtc gccggcaatg cgctcgccag
      301 tgcgttcggt gtgcgcgaca ccggtggtat cgactggatc cgccacgtgt tccagatcgg
      361 catcgccgcc gtcctcatcg ccttcgtcac ccccatgtgg gcccgacggc acgcctgaca
      421 tctcctccgg ccccgcagcc ccgccggtcc cccgggaccg gcggggctgc cgtatgtcac
      481 gccccggcga cgtcccggga aaattgaggg aaacccgcgg tcaaccgaat cgggtacccg
      541 cacaactctc ctacagccac gggccgtccg gcccgcggca tccgcgcagg aagcaggggg
      601 gcgccagtga caggcggcgg gcaccagacc actccggggc agacgctgac cgacgggttc
      661 gacgcggtac gtgtggccgt ggcgggaccg ctccgtgacc atctgacgag cgccggcgag
      721 agcaccgccg acgccggtgc cgcgcgggcc gaactggccg ccctggtggg cgagcacctg
      781 gacgacgggc ccggtgtcct ggtgctcacg gggctgcccg ccgaccggga gggcggagag
      841 cgggccgtgc tgcgggccac gcggctgctg ggggaaccgc tgccgcagaa ccgggagggc
      901 accctggtcc gcgaggtgag ggaccgcggc atgagcatca gccagcgggg ccgcacccgc
      961 tactcggact cccgcttcgg cggcgacctg cacacggacg gcgcggaggc accgctgccg
     1021 gcgccggacg tgttcaccct cttctgcgta cgccagtccg tgcacggcgg cgccctgcag
     1081 tgcctgcacg tacgggaggt ggagcgggcg ctcgacccgg aggtgctcgc cacgctgcgg
     1141 gccccgttcc ggttcgaccg ccgcggcgac caggagcccg ggcaggaccc cacgacggcc
     1201 aagcccgtgc tcttcagcca gcgggggcgc ccggccatca cgtacctccg cagctacatc
     1261 gagcacggcc acgaccaccc gggggtgccc gcactgacca ccggtcagcg cgcggcgctg
     1321 gacgccctcg acgcgctgat cgcctccagc cccgccgtcc tgaccggcaa gctgcgggag
     1381 ggggagctcg ccctgttcga caacctctcg ctgctgcacg gccggaccga gttccaggac
     1441 gagcccgacc acacgcgcct gctgctgcgc acctgggtgc ggcgccactc cgacgagcgg
     1501 tcatgaaccg gggcccggca cccgccgcgg agatcgtggt ggcgcccaac tgcatgcgcg
     1561 gttacgcctc ggccgccgag gtggcggccg cgctgatcac cggcgtccgc cgggtgcggc
     1621 cgcgggtgcg ggcggtggcg cggcccctcg ccgacggggg cgacggcacc ctcgacgccc
     1681 tgtacgccgc gtgcggcggc gtccgccacc cggtggcggc cgtcgatgtg ctcggccgga
     1741 cgcggaaggc gcactggctg gcgctggacc ggcgcacggc cgcggtcgag acggccggcg
     1801 tctgcgggct gggggccctg cgcccccggg aactgcggcc gctgcgggcc acgtcggccg
     1861 gggcgggcca ggccgtcgcc gccgcggtcg aggccggggc caccacggtg ctggtcggcc
     1921 tgggcggcac cgccgtggtc gacgggggcg ccggggcgct ggccgcgctc ggcgcacggt
     1981 tcctggaccg cgacggccac gaggtggaac ccgtaccgga gcgcctcccc gacgcggtgc
     2041 gcgtggacct gagtgccgcg cggcggctgc tggagggggt gaccgtgcgg ctgctggccg
     2101 acgtgcgcac accgctgtcg ggcaacctgg actccttcgg cgcccagaag ggcgtcaccg
     2161 ccgagaaccg cccggccgcg gtccgggccc tgcagcacct gacctcgctg ctgggacagg
     2221 cgggggacct cacggcggcg gaccgcttcc gcacgccctg gttcggcgcg ggcggcggca
     2281 tcgggttcgg gctctccgcg gtggcggcca ccacggcgga gagcggcacg gaagcactgc
     2341 tggacatcac cgacccgggc ggcagcatca gtacggcggc cctggtcatc acggcggagg
     2401 gcgccatcga cccgggcacc tggcagggca aactgccggg caccatcgcc cggttgcgcc
     2461 gggaccgggg actgccgacc gccatggtcg ccgcacgcgc cgaggcggac gccgccacgg
     2521 cggacccgct ggtcaccgtc catctggccg ccgacccgcc gctggacgcc ccgctggtgg
     2581 ggcccgccct ccacgaggga ctggcacggg ccgcggccgc ggcctgccgc acctgggcgg
     2641 tcgccgccgc ctgacggccg agcaccacga agagcggcgg ggatccctgc ccaccgctcg
     2701 cgcaacgaca cgtccggaca acagacgtaa ggatgctgga gccctatgta cgccagtgac
     2761 ggcaccgacc gcgcatccgt ggtcggcagg aagccactga ccgatttcgt catcgaggcg
     2821 ctgacgtccg tcggcgccgg tgaggccgac gcggcgctca ccgccgacgt gctggtggcc
     2881 gccgacctcg ccggggtcga cagccacggc gtcgcccgcc tccgccgcta tgtggagggc
     2941 ctgcgcaacg gcaccatcaa cggccgcgcc cggccccgcg tcgagcggga gcacggcggt
     3001 gtcagcgtcg tcgacgccca gaacgggctg ggccagcccg ccctgtgctt cgccgtcgac
     3061 ctggccgtcg agcgcgcccg ggaacacggc gtggcggcgg tggcggtgcg ccgctccaac
     3121 cacatcggca tcgccggctg gtacacggaa cgcgccgcgc ggtccggcac cttcgccatg
     3181 gtgaccacca acgccacacc gcaggtcgcc ccgacgggcg ccgcggagcc catgttcggc
     3241 accgatcccg tcagttacgc cgtccccacc gcgggcgagc ccctgtgcta cgacgcggcg
     3301 acgagcatcg tcccgcgcgg caagctggag cggctggacc gcgagggcaa gccgatgctg
     3361 ccgggctggg cggtgggccc cgacggcgcc acttccaccg acatcccgcg ggtcgtggcg
     3421 gggctcaagg ccagggaggg ctacgccctg ctgccggtcg gcgggctcgg cgaggagtac
     3481 ggcggccaca aggggtccgg tatcggcctc ctcgccgaac tgctctgcgg accgctcacc
     3541 ggagcgagct ggagcaagca cacctacggc cccgaggggg cggacctcgg ccagttcgtg
     3601 ctgtgcctgg acctcgccgc gctgggcgac gccggccgga tcacccggga cgtcgacgcc
     3661 atggccgcgg agatccgcgc cgcccggcgc gccgacgagg acgtgccggt acggctgccc
     3721 ggcgagcgcc gccaccggtg cgcggaggaa cgctcggcgc gcggcatccc gctgctgccc
     3781 ccggtcgtcc gggacctggg gaagatcgcg gagctgaccg ggatcaagcc gctcggcgca
     3841 cgggacgggc aggacgcgtg accggctccg cgcgcggctc ctcgcccgcc ccttccctcg
     3901 ccgtccggga ggacaccgga ccgcccgtca tcgacctgtc gtccgggcag atcctggagc
     3961 ccctgccgga ggcggcgcgg gcggcgatcc gccgcgcgac ggagtcgccc gaggcgtccg
     4021 ggtacgcgcc cggtcccggc cgggcggatc ttcgcacggc cgtggcggac cactacgcgc
     4081 gccggacggg cgcggcgacc gacccggacc acgtcactgt caccgccggt gcccggcacg
     4141 ggctgttcgc ggccgtcgcc gcggcggcgg ccgggcgcga ggtcctcgtg cccgccccgc
     4201 actggagcca ctacccgacg gtgatccggc aggccggggc ggtgcccgtc accgtggccg
     4261 gcgacccgct gcacgggctg ctcgtcgacc cggcgcgcct cgacgcggcg tggacgccgc
     4321 gcaccggggc cgtgctggtc aacagcccgg tcaacccgtc gggggcctgc tacgacgagg
     4381 ggcggctgcg ggagctgcgc gcctgggccg cggcacggaa cgtccggctg atcgtcgacg
     4441 acatctactg ggcgtacggg tcgcacatcg acacccggct gctgcccggc ccgcacgagg
     4501 tcgtcgtggg cggtgcgtcg aaggtgtacg ccctggccgg gctgcgcatc ggctgggtgt
     4561 gggccgaacc ggcgctcggg gcggccgtgc gggagatcgt ggagcacacc acggggcccg
     4621 tgtcggggcc ggcccaggcc gccgcggcgg cggtcctcgc gtacgagaac ggcacgggcg
     4681 gcaccggcgc ggccgtcgcc ggggccgggg tcgcccggcg ggccgaccgg ctggcccggc
     4741 agcgcgccga ggcggtccag gcgatggccg ccgtcccgta cctgcggccg gttccgccgg
     4801 ccggcgggat ctatctctgc ctcgacgcct ccgaggccct ggggctccgg ctgctcggcg
     4861 ccggggacga ccaggagttg tgccgggccc tgcgcagcgg ggcgggggtc ggtctgcgcg
     4921 cgggctccac cttcggcatg ccggggttcc tgcggctgtg cgtcgccgaa agccatgagg
     4981 ttctgctgac cgccgcccac cgcctgacca cgtgtctgac ggctgcggcg cgcgaggtca
     5041 cccatcactg aggggatacc aatgaccatt gcttcgtatg gaccatccac cctgcccggc
     5101 tcgcgtgccg ccacgctgcg ggacgccttc gcgaacggcc ggctcgtccg ggtggccggc
     5161 gcgcacgacg ggctgtcggc ccgcctggcg gaggaggccg gcttcgactc cgtgtgggcc
     5221 tcggggctgg agatctccgc tgcccacggg ctgccggacg tgagtctcct cggcatggcc
     5281 gagtacctgt ccgccgccgt cgccatgcag cgctcggtgt cggtcccggt cgtcgccgac
     5341 tgcgacacgg gcttcggcgg cgtcctcaac gccgcctaca cgatgatgcg gtacgaggag
     5401 gcgggcgtcg ccggggtctg catcgaggac aagatcttcc ccaagcgcaa cagtttcgtg
     5461 aactccggcc agaagctgct ggacgtcgac gagttcggcc ggaagctgga ggcggccaag
     5521 cgcgcccagg tgtcctcgga caccgtgctg atcgcccgga ccgaggcgtt catctgcggg
     5581 ctgggcctgc aggaggcgct gacgcgctgc caccactacg tcgacgcggg ggccgacgcc
     5641 gtcctcgtcc actccaaggc ggtggactcc ggcgaggtcg tctccttcat gaaggagtgg
     5701 aatcaccggg cgccggtcgt ggtggtcccc acgacctacg cggacttctc cgccgccgag
     5761 gcgcaggagg cggggatctc catggtcatc tacgccaacc agggcatgcg ggcggccatc
     5821 accgccatcc gcagcacctg ggccacggtc ctcgccgagg gctcgaccgc gccggtggag
     5881 ccgcgcatcg cgtccgtcaa ggacatcttc gccatctccg gcatggacca gtggctggac
     5941 ctcgaccgat gagcgaccgg atcaccgcgg aggagttcgt cgcggcgctg cgcgctcacg
     6001 gggtgcagcg ggtgacgggt gtgccgtgcg gccacctcgc cgggccgtgg gcgctgttcg
     6061 acggtgccgg ggacctgacg cccgccgcct cggagggcgc cgccctcgcg ctggcggccg
     6121 gctgggagtt ggcgggccgc acctcggtcg tgctgtgcca gaactccggt ttcggcaacc
     6181 tcgtcaaccc gctcacctcg ctcctgctcc cctaccgggt gccggtcctc gtcgtcatga
     6241 ccatgcgcgg ctggcccgac ccggcggagg acgagccgca gcacgccgcc atgggcacct
     6301 ccaccgtcgc gctgctggag acgctcgacg tgccccacgc cgtgctatgg ccggggaagc
     6361 tggaggaggc gctggggcag gccgccgacg cacgggcggc cggcaggccg ttcttcctgc
     6421 tggtgccccg gggggccatc ggcaaggccg cgggcgcgta tcccgccggg gccccggccg
     6481 atgaccggct cacccggccg cgggccgtgg ccgccctcat ggcggagctg accgacgagc
     6541 tgatggtgac caccaccggc tacctgtccc gccaggcgca ccacgagcgg gaccgcccgg
     6601 acaccttcta catgcagggc tccatggggc acgccagtgc cgtcgggctc gggctggcca
     6661 cggcccgccc ggagcggcgc acggtcgtcc tggacggcga cggcgcgttc ctcatgcacc
     6721 tggggagcgg ctccaccatc ggctcctccg gcgcccgcaa cctcacccat gtcgtcgtgg
     6781 acaacggctg ctacgagtcc accggctgcc agccgacgac ctcgggcggt ctggactggg
     6841 cctcgctggg cacgggactg ggctaccgca cggtcctcac ctgcgactcc accggggacc
     6901 tcaccggaag cctgcgcgcg gcgctgaccg cggaggggcc cgtgctcctc gcgctcaccg
     6961 tcgtgccgac gcccggcgag gtgcaccccc gggcgaccgc gtccctcggc ccggagctca
     7021 tcgccggccg tttccgggag gcggccgcgg cggctgccgg cggcggtgcc cccgagccgg
     7081 agaggctgcc atgagccggc ccctggcgcg cggctccggt ccccggcgcg acacggtcct
     7141 gctgacgggg cggggcagct tcggccgggt ccccgggctg agcgagggcc gccgggtgct
     7201 ggtcgtcgcc agcagccggg ccctgctgcg ggcgccggtg gcggcgtggc tgccgccgga
     7261 cgcggtgacc ttcaccgcgt tccaccccaa ccccacggtg gcgcaggggg tcgaggcggc
     7321 ccggctgcgc cgggcgtccg gcgccgacct ggtggtgggc atcggcggcg gttcggccct
     7381 ggacgtggcc aaggccgccc gggtcctgcc gggcgacgcc ggggcggccg acgaggtgat
     7441 cgcgggccgc aggccggtgc cggagggggt gccggagctg ctgctcgtcc ccaccacggc
     7501 gggcaccggc agcgaggtga cgcagttcgc gacgctctac cgggggcacc gcaaggtctc
     7561 cctggacacc ccggcggccc gggccgacgt cgccgtcgtg gacccggagc tgaccgagac
     7621 gtgcccggcg gacctcacgt ggacgtgcgc cttcgacacg ctggcgcacg ccgtcgagtc
     7681 gctgtggtcg gtccggtcca ccgcggagtc ccgcgagcac gccgtggcgg cgctgcgctc
     7741 gtcgctgccg gtgctgcggt gcgccgggga cctgccgtcc ccggccgaac gcgacgccct
     7801 gagccgggcc gccaccctgg ccgggcaggc catcgacctc acgcgcacca ccgccgcgca
     7861 cgcgctgtcg tacccgctca ccgcgcacct gggcatcccg cacgggctgg cctgcgcgct
     7921 caacctggcc tggctcgctc cgctggtgga ggcggccggg ccggagcggg tgaccgaccc
     7981 gcgcggtcac gcggcggtgc gggaggcggt cggcacgctg cgggagctgt tcggggcgga
     8041 cgagcagggc acggacctgg ccggggcgct gcgggccctg ctcgcccggc gcgcctcctt
     8101 cccgtacgcc ggcgcgccgg acgccccgta cgacctgctc gtggcggagg ggctgtcctc
     8161 cgaccggatg tccgggatgc ccgtgcgtct ggagcgccac gaggcgcggg cggggctgga
     8221 gaccgtcctc ggcgccggca ccgagcgaaa gcgaggcacg acatgcgcaa ctacagggtg
     8281 acggggccgg tcgaggtgcc ggacggcacg ctcgccgcca tgacgacccg gatgatcagc
     8341 caccgttccg acggcttccg cgacctgttc ggcggcatcg cgccgcggct cggggcgctg
     8401 ttcggcaccg caggcacggt gctgcccctg acgtgctccg ggacgggcgg cctggaagcg
     8461 gtcgccgcgt ccctgctgcg gcccggggac cgcgtcctgt cggtccagct gggctacttc
     8521 ggcgagcggt tcgccgagat cgcggagcac cacggtgccg tggtggacgt gctggccgca
     8581 ccgtgggggc aggtggtgga caccgccctc atcaccgagc gcctggccgc ggggtacgac
     8641 gccgtcctgc tcacccacaa cgagacctcc accggtgtgg tggcaccgct gcgcgcgtgg
     8701 gctcaggcga tccgggcggt cagcgactgc ctgatcctcg tggacgtggt cagcagcctg
     8761 gccgccgtcg agatcggttt cgacgagctc gggctcgacg cggcggtggg ggtgacgcag
     8821 aaggccctgg cctgcccgcc cgggctgtcc ctcgtcgccg tctcggagcg ggcgctggcc
     8881 cgggcggccg aaccgggcga ggggtcctac tacttgagcc tcgcccgcgc ggccgagcac
     8941 gcccgggccg gcaccacgac gtacacgccg gccctgtcgg tgctgtacgc cctcgacacg
     9001 gcgctcgccg cgatcgagaa ggagggcgtc gaggcggtgt gggagcgcca tgcccgcacg
     9061 gcacggcggt gccgcgacgc cctgcgcgcc cgggggcttg tcgtcgtccc cgacgaggcg
     9121 cacagctccc ccacggtgac cgccgtacgg ctgccggccg ggggcgcggt gcgggtgcgc
     9181 gaggcgctgg ccgccgagca cgacacctgg gtgtcctccg gacgcggccc ctggaaggac
     9241 gaggtgctgc gcatcgggca catggggccc gtcgaaccgg ccggcgtcga cgcctgcgcc
     9301 gccgccatcg cggcctgcct ggacggttcg gccggcggcc ccgcggccgg ggcgccgccc
     9361 gcggccgggg cggcgctcga cgtgcgcggg acagacggtg ccgacggtct ggggccggac
     9421 tgggacgggc tggtggcgcg gctggacgcg ccggtgttcc acacccgggc gttcctgcgg
     9481 gcctacgagc accatcccgt ccagcggatc agcgagccgc gctacctgga ggtgcgccgc
     9541 gacggcgaac tggtcgccgc cgcgcccacc tacctgcagg gcgatccgct cggcctgctg
     9601 gggatggccg acggcgagca ggccctgctg tcgccgatgt ggcactcccc ggactcgcgg
     9661 ctgctggcgg ccgacgagga cgccctggac gcgctgacgc gtgcgttcgc cgcccgggcc
     9721 gccgaacttg acgccccgca gtgggggttc gccaacctgg gcaccgacca tccgctggtg
     9781 cgggccctgg agcggaaggg gttccggcgc cgggagctgg tgccccgctg gacactgcac
     9841 cggtccgacg caccggacgg cgatgcctac ctcgccggga tgcgccgttc ggtacggcgc
     9901 gactaccagc gccagttgcg caggtaccgg gagcaggggc acgcccgggt gcaccgggcg
     9961 gaccacgagg gcctggtgcc gctgctggag ctgatcgccg ccagcgccac ccggaccggc
    10021 tcgcccaagt actacgaccc gctgaagctg gcggcgttcc tgcgggaact cgacgagccg
    10081 gtacgggtcg tcgaggtgcg cgagaacgat ggcgagccgc tcgccgtggc cgtctgcttc
    10141 ctggaggaca agcgcctgca ggcatgggcc ggagggtatg tgcgcggccg cgccgacctg
    10201 cggttcagcc cgtactacgc cctgtggtgg gagatcgtcg agctcatgtg gtcggcgggc
    10261 accgagtcga tcgagtgcgg ccggctcaac gaatccttca aggagaagat gctcctccgc
    10321 ccgcagcacc tcgtggcgat gctcggccct tcgctctgac ccgcaccacc gtattcccag
    10381 caatcgagga agaggaccca tgaccacttc gcacggtctg atcgagagcc agctgtccta
    10441 ctaccgggcc cgggcctccg agtacgacgc gaccttcgtg ccgtacatgg actccgcggc
    10501 gcccgccgcg ctggagcggc tgcgcgccgg gaacatccgg ggcgacgtgc tggagctggc
    10561 cagcggcacc ggttactgga cgcgccacct gtccggcctg gccgaccggg tcaccgccct
    10621 ggacgggtcc gccgagatga tcgccgaggc cggccggcac gggctggaca acgtcgagtt
    10681 ccggcagcag gacctcttcg actggacccc cgaccggcag tgggacgcgg tgttcttcgc
    10741 ccactggctg gcccatgtgc ccgacgaccg gttcgaggcc ttctgggaga gcgtgcgcag
    10801 cgccgtcgcg ccgggcggcg tcgtggagtt cgtcgacgtc accgaccacg agcggcggct
    10861 ggagcagcag gacgactccg agcccgaggt cgccgtccgc cgcaccctcc aggacgggcg
    10921 cagcttccgc atcgtgaagg tcttccgcag cccggccgag ctgacggagc ggctgaccgc
    10981 cctcggctgg tcctgctccg tcgacgaggt ccaccccggc ttcctgtacg ccacgtgccg
    11041 ccccggaccg cggtgagccc ccggcccgcc ccgctgcccg gtccgtccgc cccaacgaag
    11101 gagacgcagt cgtgaacggt tccctcagca tcaaccagcc gggggtgcgc aaggcgatca
    11161 accggtactt cctgaaggcc agcggtggcc gcaaccggtt ccggatcatg tcgccgtacg
    11221 cgctcttccc cgagtcccgg aagctggact accagttcga ccagatcaag gccgaggtca
    11281 ccaagctcgt cgagacgcgg gacgtgcgtc cgtacggcga catcgacccg ctgcgcgcgg
    11341 cggaggtgtc caccgactgg cggctgtact acgcgtacat gctcggcgag acgaacccgg
    11401 ccgcctaccg ggactgcccc accttcgtgg acttcgccga gcggaccccg cgggtggtca
    11461 acgcgatcat cgcgatcctg gagcccgggg tgacgctgaa ggcccacgaa ggtccgtacg
    11521 cgggcatcct gcgctaccac ctgccgctga cggtgccgga gaacaacccg ccccggctgc
    11581 gcgtggacca ggagatgcac acgtggcagg agggccaggg catcctcatc gacgacacct
    11641 tcgagcacga ggtgtacaac gagagcgacg ggcgccgcgt catgctgatc atcgacatcc
    11701 gccggcccat gggcctcgtc ccggacgtgg tcaaccggct cagcctgcgc gcgaagcgca
    11761 agtggtccgc ccagttcatc aaggaatcgg gcggcgacat ctgatggtgg ccggagcggt
    11821 cgccgcgccc ggggcgccgg gacggcggcc gcaccggccg ccgccgggag gatcggggtg
    11881 acagaaggga tgccggtgtc ggaggtacgg atcctgagca gcgtggacga ggtcgggccc
    11941 gccgcctggg aggagctgac caaggcggcg gacgtcgact ccagccacgg cttcctgcgg
    12001 ttccgggagt acgtggaacc gggccgcagc gtgctgttca cgctcgggcc gcccgagcgg
    12061 ccgcgcggcg cgctgcgggg tgtggtcgcc gtaccggggt ccggtctgac cagcgatccg
    12121 tggaagttcg tcggttcgca ggccgtgctg cggctggacg ccggtacgga cgaggccgag
    12181 gccgcctcgc tccgccgcgc ccagcgcgac ctggtccgcg ccgccgcgga cccggcgggg
    12241 cgggcggggg acgacggcgg ggagccgctg tggcaggcgc tcacacgggg gttgggcgcc
    12301 tgcctcgtcg tccgggagtt cgaccgcagc gagctgctgt gccatccgga ggcggacgcg
    12361 gcggaggcgc ggagcgtggc cgcccggctg gtgcgtgccg cgcagacgtc ggcggcggag
    12421 cacggcgcgg gcgccgtggc cttcccgttc gtcagtcccc gcgacaccct gctgcgctcc
    12481 gtcctcaccg aggccgggtt ccggggcggg gcgatgacgg gcgcgtcgtg ggtggagacc
    12541 ggcgggtacg gctcctacga ggagttcctg gccgtgctgc cgagccggcg ccgccgccgc
    12601 taccgcctgg aggagcaacg gctcctggag gcaccggacc tcacgacggc cgaggtggat
    12661 ccggtgcgca acgcggcgcg gatcgccgag ctggaggcgc ggacgctggt caagcacggg
    12721 gggctggcgg acgccgaggc gatccggcgg gcgcggatcg agctcgcgga ccggctgccg
    12781 gacgacgcgg tggtcatccc cgccgtgatc cgggacggcc ggatcatcgc gtgcgcgctg
    12841 cacctgcggg ggccgcggag cgtggtcttc atgacctacg gctgcgacta cgacgtcgag
    12901 gagcggggcc cggcgtaccc gtgggccgcc ttctaccatc ccatcaggac ggcgatcgcc
    12961 cacggcgcct cgtcggtgcg gctcggcctg gaggggttcg aggcgaagac ccgccggggg
    13021 gcggtggtgg aggcgcggga gctgtgggtg tggacgccgg acgccgcggc gctggcgcgg
    13081 ctgggggacc tgctggagct cgtgggagag cggaacacct cgtacctggg ccggttctcg
    13141 cagtgaccgg caccgtccac caccggccgc ggccggacga acagggagca gtgcggctgt
    13201 catgaccgcc ggagaaaccg ccgaggagat ccaggacccg gccgccgagg acgggggcgg
    13261 gccggaccgg ttgctgctgt cggcgctggc cgtcggcgcc ttcgccatcg gcacggacag
    13321 cctcgtcatc agcggcctgc tgaaccggat cgcctccgat ctgagcgtct cccccgcgac
    13381 gacgggccag ttgatcagtg tcttcgcgct ggtctacgcc gtcggggcac cggtcctggc
    13441 cacggtcacg gccgggttcg accgcaggcg gctgctgctg gtggccctga cggtgttcat
    13501 cgccgcgaac gtgctggggg ccgtggcccc gaactacccg gtgctgctgg cgtcccgggt
    13561 gctggcggcc gtgggggcgg ggctctatct gccctgcgcc atggtgatca cggtgagcgt
    13621 cacgccggag cgctggcggg gccgggggct cgccatggtc gcgggcggga tgtccgcggc
    13681 caccgcgctg ggcgtgccgc tcggcaccct gatcggtgcc gtcggcgact ggcgggccac
    13741 cctggtgctg gtggcggtgc tggccacggt cgcggtggcg gtgctggcga aggccgtgcc
    13801 acgggtggcg gccccggcgg cggtgaccct ggggcagcgg ctgcggtcgg ccgcgcaccc
    13861 gcaggtgctc atcgccctgc tggcgaacgc cctggcgtgc gcgggcgagt tcaccgtcat
    13921 ggtgtacgtg gctccgctcg ccgaggacgt caccggcgtg ggggcggccg gggtgagcgc
    13981 cttcctgctg gtgtcgggcc tcgccgcgct cgccggcagc gcggtcgggg ggcgggcggc
    14041 ggaccggttc ggcggccggc gcgcctacaa cggggccgtc gccgtgctgt tcggcgggct
    14101 ggccgccctg gtgctgctca ccctggcgga cgggcgcggg tcctgggtca ccgcgggggt
    14161 cttcgcgctg ctgctgtgcg tcgtcagcgt cgcgtcgtgg gcgctgcccc cggcgcagaa
    14221 ccacgcgatc gccggactgg acatccccga gccgaccgtc gccctgtcgc tgaacggctc
    14281 ctcgtcctac ctgggcctgg cgatgggcgg cgtgctgggc ggtctggcca tggagcacgg
    14341 ttcgagcacc acactcaccg cggcgggcgc ggccgtcgaa ctgtcggcgc tggcgctgct
    14401 gctgactacg gccgtggtga cggcgaagcg gcgccgggcc accgctcccg ggcctcggcc
    14461 aggaaagtga ggaacagcga gatgacgagg ttgagcagca gggcgaccag tcccacgtag
    14521 acgcccgccg agccggggat gccgagcggt acgacggcgg agaagccgcc gcgtaccacc
    14581 agggccgtac cgaggagcat ccccgcgctc cagccggcca gcagcgcggc ggggcgcagg
    14641 cgcgccgtgt acaggccgac ggcgacggcc gggaagatct ggaggatcca gacgccgccg
    14701 agcagctgga ggttgatggc gtcctggtcg cgcagcccga agacgaagac gaccgcgccg
    14761 agcttggcgg tgagcgacac cgtccgcgcg atccgcacct gccgtttggg ggtggccgtg
    14821 gggtggacgt actcgacgta gacgttgcgg acgaacgagg tggcggccgc gatcgacatc
    14881 acggcggccg ggacgagcgc gccgaccgtg atggccccga acaccagccc caccagcggg
    14941 ccgggcatca gcagggccgt cagcatcgga acggccgcct cggcgccgtt ctcgggggtg
    15001 tccacgccca tggcgatggc ggcgatgccg agcaggccga agagcgccag gaccaccgtc
    15061 cacaggggca gggcgatgct gacccggcgc aggacggccg cgtcggaggc ggcgaacgcc
    15121 gcggtgagga cgtgcgggta catcagcagg gcgagcgccg agccgatcgc gagcgtgacg
    15181 aaggcgggct gctgccccgg ggtgaggacc agggaggcgt tggccgtcga gtccgacagc
    15241 cgggtggcgg ccgcggcgaa gacgccctcg gggccgttca tccggtccag caccagccag
    15301 cagacggcca ccgccgagcc gaagacggcg acgcccttga gcgcggagat gacggcgggg
    15361 gcgcgcagcc cgtgccggta ggtggcgatg gccagcccgg cgaagatggc gatcatcacg
    15421 caatcaccca ccgcggcccg ggacggtacg cccgccgcgt ccagcaccgc gcgtatgccg
    15481 agaagttgca gcgccaggta cggcatggtg gcgaggatgc cggtcagcgc gaccacgagg
    15541 gccagcgggg ccgagtcgta ccgccggcgg acgaagtcgg cggcggtgac gtgcccgtgc
    15601 ttccgcgcca ccgcccacat ccggggcagc aggacgaacg ccagggggca gacgatgatc
    15661 gtgtacggca gggcgaagaa ggccggtgcg ccgttgccgt acaccaggcc gggcacggcg
    15721 gtgaaggtgt acgaggtgaa gatgctgccg cccagcagca gccaggtcca gccggtgccc
    15781 aggctccggt ccgccagcgc ccacccgccg agcgacggca ggtcgctgct ggggttcagc
    15841 cggcgcgccg tgaccgcgag cagcgaggaa ccgccgatga cggccatgag cgtcgcggcc
    15901 atcgggccta cagtcatcgt cgctgcctct ggtggtgtgg gggtcccttg cctgactgac
    15961 gaggtgtgcg agagcgccgg ccgggtgggg ggacggtagg gtcttgcggt gctgtcaacc
    16021 ggcgcacggg caacggcaac tcttacacaa accaacagga ttgaggagag tccgggtgga
    16081 acagctcggg gacgtaccgc gccgtcggcc gtggtcatgg cgcagatgcg tcgccgccgt
    16141 cgtcctgctc gcgcccgtcg tggcactgtc gtgggttccg tggtacgccc aggaccggcc
    16201 acggctggcc ggagtgccgt tcttctactg gtaccagctc gcgtggatcc ccgggtgcgc
    16261 cttcgccatg ctcgccgcgc acctgctcac ccgggcccgg ccgcggcgcc ggtgacgtcc
    16321 gccggccgtt tcccggtttt ccgtcctctt cctgtcctct ggttgatacg ttcacgcaac
    16381 ccgtaagcaa cagggggttg ggtcgacgac cggggggcgg gcggggatgc gtgaagaggc
    16441 gctgctcgcg gccttcctct cggtcgtcgg cgcgacgtcc ttatgggcgg tgtcggcgcg
    16501 gcggttccac gcccgcgaca cccttccctc gctggagggc tgggccctcg ccgaccgctc
    16561 cctgggcacg ctgtggacct ggctgctgct gggcggcacg gtgttcaccg cctacacctt
    16621 cgccgccgta ccgggtctgg tgtacggcga cggggcctcc ggcttcttcg ccctgccgta
    16681 cacggtgatc gtctggccgc tggccttcgt cctgctgccc cggctgtggg cgatggcccg
    16741 cgcccacggc cacatcacgg tggccgacgt cgtccggggc cgctacggct cgccgtccct
    16801 ggcgctcgcg gtggccctga ccggcatcct ggccacgctg ccctatctgg cgctgcaact
    16861 ggtgggtctg cgcgcggtgc tgacggtgag cgggctctat ccccgcggcc ccacgggtga
    16921 tctcgcgctg atcgcgctgt tcgcggtgcc ggccctggcg tcgtaccgct acgggctgcg
    16981 ggcccccacc gtcatctcgg ccttgaaggg catcctggtc ttctgctccg cattcgccgt
    17041 catggcgctc gtcctggggc ggctgggcgg tcccggcccg atgttcgacg ccgcggcgct
    17101 gcacctcgcg gagcgggcgg cgccggacgc cgcgctggtg ccgggcccgc accagcaggg
    17161 cgcgtacgcc acgctggccc tcggctcggc gctggccctg ctgatgtacc cgcacgtcct
    17221 caccgccggt ttcgccgcgt cgagcgcggg caccctgcgc cgggcgtcgg tcgcgctgcc
    17281 ggcctggacc gctgtgctcg ccctgttcgg gctgctgggc gtcgcggccc tggcggccgg
    17341 catccacacg ccgcccggcc gcgccgagga ggccgtaccg ctgctggtcg gctccttcct
    17401 gccggcgctc ctggcggggc tggtgctggg ggcgctggcc gtgggggcgc tggtcccggc
    17461 cgccgtgatg tcgatcgccg ccgcgtccct gttcgtgcgc aacgtctacg tcgagtacgt
    17521 gcagccgacc gccacgccga agcggcaggt gcggatcgcg cgcgtggtgt cgctcgtggt
    17581 gaaggtcgcc gcggtggcct tcgccgtcgg actgcgcgac caggacgcca tcaacctgca
    17641 actgctcgga ggagtctgga tccttcaggt cttccccgcc gtcgccggcg gactgctgac
    17701 gcggcggctg cacgaacgcg ccctgctggc cggatggggc acggggatgg tcgccggcac
    17761 cactctcgtc gtgggccacg ggttctcctc cgtggtgccc ctccccttcg gcggccggga
    17821 gctggaggtc tacaccggcc tcgccgcctt cctgctcaat gtcgcggtcg ccgtggtcct
    17881 caccacggtg ttcgaccgcc tcggtccacc ccgcggtgcc gcaaccaccg ccctgccgca
    17941 acgcccggcc gccgggcgcc gcacgacgag aggaacgagc agcccatgaa gcggacccgc
    18001 caggacgtca tctcctcgtt gccgtcgacc gccacccgga gggcgctcgg agaaggcgat
    18061 gcgcccgggg ccgcccaggc gcccctggtc gacctggccg aactggagcg ggaggccggg
    18121 ctgtcccggc tgttcgacct ccactacgcc tcgatgctgc gtctggccac cctcctcggt
    18181 gccgacgacc cggagaacat cgtggccgag gcgtactacc agatctaccg aaaatggcgt
    18241 aagttgcggg attccagctc cgcggaggca tacctgcgct ccgtcgtgtg caatctcacc
    18301 cgcatgcgga tccgccacct ccaggtcgtc cggaagcacg tggagacacc ggacgcgtcc
    18361 gtcgtcccca ccgaggcctc ggcggcctcc gcggaggcgt ccgccctgct ccgtgacgac
    18421 cagcgcgtgc tcgtggccgc cctgcgcaag ctgccgacgc ggcagcgcga ggcgctcgtc
    18481 ctgcggcact ggctcgggct gaaggagtcg gagatcgcgg aggcgatggg tatatcgtgc
    18541 ggttctgtca agacgcatac cgcacgcgga attgccgccc tcacccaggc gatggaggcc
    18601 cgacgatgag cgattccccc tcgccgacct ctgccgccga caccgagcga cagctccgcg
    18661 aggccctcgc ggcactggcc ggcgacgtcc accccgcgcc gagcgcctac cgcgcggcac
    18721 gcggcgactg gctgcgccgg gagcgccgcc gccgcgtggt cctcgccgcg ctgatcaccg
    18781 tgctgttcac cctggtgacc ctggtggggc tgtgggtgct gaaccaggtc ccctcccggc
    18841 ccggcgtcat cttcgacgac gccccgcgca ccgggcagca ccagccggcg aaccgcggcg
    18901 gggccccgta gccctccggg ccccgccccg acgccgcatc gccggcagga gcacacggca
    18961 ccaccccgga cccgtgaccg caccggtgga ccgggagcgg cccgcccgcc ggtccgcggg
    19021 acgacgggac caccgcgccg gcctcaccac gacggcacga cgggcgcggg caccggacgg
    19081 tagggtcacg gcgtccgagg aaccgcacac agcccggggg tgacgcgtga agcggccgac
    19141 catcgcggac atcgcccgcc acgccggcgt ctccaaggtg gccgtctcct acgccctcaa
    19201 cgaccgcccc ggagtgtccg acgcgacccg cacctcgatc aaggcgatcg cggaggagct
    19261 cggctggcgt cccaacagtg ccgcacgggc cctcaacggc gcctgcgccc aagcggtcgg
    19321 cctcgtggtg cgccggcccc cctccacgct cggcgtggag cccttcttca tggagctcgt
    19381 cagcggcatc gggagcgtcc tctccgcgca gtcctacgcg ctgatgctgc agatggccga
    19441 ctcccacgag caggagctgg aggtccaccg ccgctggtgg ggggagcgcc gggtggacgg
    19501 cgtgttcctg gtcgacctgc actccgacga cgcccgcgtc cccgcggtcg aagccctcgg
    19561 cctgcccgtc gtcgccatcg caccgcccgg gacctcggga agcctgccgg ccgtctggtc
    19621 cgacgacggc gagagcgtac gggaggcggt gcgctacctc gccgcgctgg gccaccgccg
    19681 catcgcccgg gtggcaggac ccgcggagct cgcgcacacc gccgtccgcg acctcgcgct
    19741 gcgggaggcg tgcgcggagg ccggactgcc cgagccggag accgtccaca ccgactacac
    19801 cggcgaggag ggggcccgcg ccacccgcca cctgctcatc gccgcgcggc gccccaccgc
    19861 gatggtcttc gacaacgaca tcatggcggt ggcggcgctg tccgtcgccc aggaactcgg
    19921 cctggacatc cccgccgacc tgtcgctcgt cgcctgggac gagtcgcccc tcacccaggt
    19981 cgtccggccg cccctgtccg ccgtggcgcg ggacatcccc gcctacgggg cgaccgccgc
    20041 ccggtcgctg ctggcgctca tcgcggggga gagcgtcggc gacgtccggg gggcgcccgg
    20101 gaggctcgta ccgcggggca gcacccgccc gccgcgcacg gcg
//
