BGC0000901 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000901 (Aspergillus niger)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	23,114	ferrichrome	other:other	100%

BGC0000901 - Region 1 - NRPS

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Location: 1 - 23,114 nt. (total: 23,114 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,115
Label		BGC0000901

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000901	1.00	Other	ferrichrome	Aspergillus niger
BGC0000900	0.34	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.34	NRP	dimethylcoprogen	Alternaria alternata
BGC0001261	0.30	NRP	AM-toxin	Alternaria alternata
BGC0000342	0.26	NRP	enniatin	Fusarium equiseti
BGC0001132	0.25	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002199	0.25	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0001128	0.25	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002710	0.25	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000293	0.25	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000901	1.00	Other	ferrichrome	Aspergillus niger
BGC0000900	0.67	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0001261	0.63	NRP	AM-toxin	Alternaria alternata
BGC0000342	0.60	NRP	enniatin	Fusarium equiseti
BGC0001132	0.59	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002199	0.59	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0001128	0.58	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002710	0.58	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000293	0.58	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 23114:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu) + (Arg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_orf000000

Search NORINE for peptide: strict or relaxed

AMP-binding (28..433): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DVSDVGPPTK
Nearest Stachelhaus code(s):: Arg DVSDTGAPTK (79% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1685..2080): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSDVGPPTK
Nearest Stachelhaus code(s):: Arg DVSDTGAPTK (82% 8Å match)
Stachelhaus code match:: 80% (moderate)

ctg1_orf00001

Search NORINE for peptide: strict or relaxed

AMP-binding (0..344): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVCIHILTFK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

AMP-binding (883..1166): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ---LTGSPTK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

AMP-binding (2115..2512): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSDVGPPTK
Nearest Stachelhaus code(s):: Arg DVSDTGAPTK (79% 8Å match)
Stachelhaus code match:: 80% (moderate)