LOCUS       BGC0000903             12003 bp    DNA     linear   BCT 03-JUN-2006
DEFINITION  Streptomyces cattleya fluorometabolite biosynthesis gene cluster.
ACCESSION   BGC0000903
VERSION     BGC0000903
KEYWORDS    .
SOURCE      Streptomyces cattleya
  ORGANISM  Streptomyces cattleya
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 21:00:47
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12003
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..12003
                     /db_xref="taxon:29303"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces cattleya"
     subregion       1..12003
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000903"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12003
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(127..795)
                     /gene="flE"
     CDS             complement(127..795)
                     /codon_start=1
                     /db_xref="GOA:Q1EMW2"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="UniProtKB/TrEMBL:Q1EMW2"
                     /gene="flE"
                     /product="putative DNA binding regulatory protein"
                     /protein_id="CAJ20002.1"
                     /transl_table=11
                     /translation="MQRPAAVVHHVGVPAAIWLKLIETLPAILWVGFAAVVYFSLRQTI
                     VQRMVPRLTAVRALGVELELARELLDQAQEESPTTVTPTARRTALGRLEHAADLLRGGN
                     VLWVDDRPEGNSPLVELFRTAGMNVELALSTEEAVPLLRRRPYDIIISDFDRNGDSEAG
                     IKMLRLLEQYHIDVPVLIYTGRFDPERGVDHRIFAGTSAPVELVHYVVDLMERARLGSL
                     "
     gene            complement(854..1504)
                     /gene="flD"
     CDS             complement(854..1504)
                     /codon_start=1
                     /db_xref="GOA:Q1EMW1"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006402"
                     /db_xref="InterPro:IPR006439"
                     /db_xref="UniProtKB/TrEMBL:Q1EMW1"
                     /gene="flD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 142.4; E-value: 2.5e-43)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative dehalogenase/phosphatase"
                     /protein_id="CAJ20003.1"
                     /transl_table=11
                     /translation="MRVPPQLVIFDCDGILVDSEPLAIRAHVAVGAELGWPLTEDEVVD
                     LFVGRSNASVDELIAARLGAPAAATWRRRFEALHREAVDTELTAVPGITEALAAIPVPT
                     CVASSGTHAKMRHTLGRTGLYDHFAGRIYSATDVRHGKPAPDLFLHAAASMGVPPSACV
                     VVEDSHHGLQAARAAAIPALAYASGVTPEARLRGPGTVVFREMRELPGLLGVG"
     gene            1845..3038
                     /gene="flC"
     CDS             1845..3038
                     /codon_start=1
                     /db_xref="GOA:Q1EMW0"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR016196"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="UniProtKB/TrEMBL:Q1EMW0"
                     /gene="flC"
                     /product="putative MFS permease"
                     /protein_id="CAJ20004.1"
                     /transl_table=11
                     /translation="MGAGGRAPGPRPWVRVALAMFAVGWGANQFSPMLLVYHEQRRLSQ
                     VVLAAMFGCYALGLIPALLVAAALSDRMGRRRLMRPVLILSTVASLVLVAGAVATPALF
                     AGRLLAGVASGTAFAPGSAWVKELSADAPGGSGARRATVALSAGFGGGPLVAGAVAQWL
                     PYPQVLPYLVHIAVMLVVAPLAWRAPETVTPGRRAGGGPGRGGVRAAVAHPVFLRTVVP
                     TAPWVFATATVGFAVLPGLVIRGGDGLVLSGATAGLVLGTGVLVQPLARRVERWRAGAV
                     LVAGVLVAAAGLLLAAVTAATAEPTLLIPAAVVLGAAYGLLLVAGLGRVQALAPPEDLA
                     GVTAVFYCLIYLGFAAPYVVAAAGALLSPAALFCVAAGAVTATLPLLLGTGGVRAPR"
     gene            complement(3053..3952)
                     /gene="flB"
     CDS             complement(3053..3952)
                     /codon_start=1
                     /db_xref="GOA:Q1EMV9"
                     /db_xref="InterPro:IPR000845"
                     /db_xref="InterPro:IPR001369"
                     /db_xref="InterPro:IPR010044"
                     /db_xref="InterPro:IPR018099"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="catalyses phosphorolytic cleavage of
                     5'-fluoro-5'-deoxy-adenosine"
                     /gene="flB"
                     /product="5'-fluoro-5'-deoxy-adenosine phosphorylase"
                     /protein_id="CAJ20005.1"
                     /transl_table=11
                     /translation="MRARKSGNEQRNADLGIIGGSGLYEFPGLTDPEEFPVETPYGPPS
                     APPVVGTVGGRWVAFLARHGTGHRIPPSRIPVRANLYALKALGVTEVVSVSAVGSLREE
                     YAPGHLVVPDQIIDRTRGGRPATFFSSGVVVHVSLADPYCPRLRAALTDAARAAHPTVH
                     PAGTYLCMEGPQFSTRAESQLYRAWGMDVIGMTAQPEAKLAREAELCYAGLSLVTDYDC
                     WHTGHDSVDARTVAEVMAANVIAARAVLSGLAHATAPADCACHHALDGAVLTDPLAAAQ
                     VPEEEVPALLRKGFARRG"
     gene            4172..5071
                     /gene="flA"
     CDS             4172..5071
                     /codon_start=1
                     /db_xref="InterPro:IPR002747"
                     /db_xref="PDB:1RQP"
                     /db_xref="PDB:1RQR"
                     /db_xref="PDB:2C2W"
                     /db_xref="PDB:2C4T"
                     /db_xref="PDB:2C4U"
                     /db_xref="PDB:2C5B"
                     /db_xref="PDB:2C5H"
                     /db_xref="PDB:2CBX"
                     /db_xref="PDB:2CC2"
                     /db_xref="PDB:2V7T"
                     /db_xref="PDB:2V7U"
                     /db_xref="PDB:2V7V"
                     /db_xref="PDB:2V7W"
                     /db_xref="PDB:2V7X"
                     /db_xref="UniProtKB/TrEMBL:Q70GK9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="synthesis of 5'-fluoro-5'-deoxy-adenosine"
                     /gene="flA"
                     /product="5'-fluoro-5'-deoxy-adenosine synthase"
                     /protein_id="CAJ20006.1"
                     /transl_table=11
                     /translation="MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCH
                     SMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWA
                     GSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVA
                     IPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHR
                     TDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAAS
                     LAYPYHLKEGMSARVEAR"
     gene            5196..5753
                     /gene="flF"
     CDS             5196..5753
                     /codon_start=1
                     /db_xref="GOA:Q1EMV7"
                     /db_xref="InterPro:IPR001387"
                     /db_xref="InterPro:IPR010982"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR013096"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV7"
                     /gene="flF"
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 80.8; E-value: 2.4e-24)"
                     /gene_kind="other"
                     /product="putative DNA binding regulatory protein"
                     /protein_id="CAJ20007.1"
                     /transl_table=11
                     /translation="MERAEGVGVTVGAQVRRLREFRGLSVAELSRLSGVSRATLSMLES
                     GRGNPTIETVSAIAVALRLPLGDLLVDPTPPEPVLRPGTPRPQTSRQDLLDRIGAGGHS
                     EIWRLRLCGAGRRVDSPPHTRGTLERVVALRGRLRLGPVDRPVVLATGDFVVFPADEPH
                     FYEAVDDEDVDAVIVMTYPAAS"
     gene            complement(5947..6651)
                     /gene="flG"
     CDS             complement(5947..6651)
                     /codon_start=1
                     /db_xref="GOA:Q1EMV6"
                     /db_xref="InterPro:IPR000792"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="InterPro:IPR011990"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR016032"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV6"
                     /gene="flG"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 104.9; E-value:
                     5.8e-32)"
                     /gene_kind="regulatory"
                     /product="putative DNA binding regulatory protein"
                     /protein_id="CAJ20008.1"
                     /transl_table=11
                     /translation="MTLHRGAATAAVRRQQAAIRLAVVDDNVFLRTGLAHVLAAEPALE
                     VVAESAHVREGLSALRARQPHVVLLGVASGGREPYGDVAELRRATPVSRIVAMLAHDDP
                     GAVRRLLAAGAQAAIAQYSSPEELIGTIRGVAGHRDRVVLSVSQRTLAGLRETGPHLLT
                     ARELQVVALVARGLRNSQIARELVITEGTVKRHLSNVYAKLDAACRTEAVRKAVERGMV
                     RTPVPITDYDLA"
     gene            complement(6648..8051)
                     /gene="flH"
     CDS             complement(6648..8051)
                     /codon_start=1
                     /db_xref="GOA:Q1EMV5"
                     /db_xref="InterPro:IPR006153"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV5"
                     /gene="flH"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 240.2; E-value:
                     6e-73)"
                     /gene_kind="transport"
                     /product="putative Na+/H+ antiporter"
                     /protein_id="CAJ20009.1"
                     /transl_table=11
                     /translation="MSLTTVELAHVLIALGLLTVLAHAGAQIFQLLRQPPVIGEIVGGL
                     VLGPTVLGALWPTAETWLFPAKGATGEVLGAFYSIGMLLLVYLTGAELRGHVARSDRRT
                     MVWVAGAGLFVPFAAGLLVANSVSLPGLSGPHGNPASLALVFGMAIAVTSVPVISRIML
                     DLGILRTVFARVVLAVAVLEDVVLYALLAVVLGIAQARAGDSYGVGGALSRVSLPWAVV
                     FFSLVPVVFFGLFLWRGRAAFDALRSGRWNVLERRSPTAFRIAYLFALCLACSGLGIDP
                     MFGALAAGLSAGGPVPGEERAAPAVPEAAADAAPGSYQTLRAISLAFFVPVYFAVVGLK
                     LDLIRHFDPVFFLWFLALACVVKSAGVWAGARLAGQDAASAGNIAVAMNARGGPGIILA
                     SVTYAAGVISEDFFTSLVVLSIVTSQAAGVWLGRTVRRHRPLMSQRRPTGGERGTPDPE
                     TTRRKAETA"
     gene            8317..9786
                     /gene="flI"
     CDS             8317..9786
                     /codon_start=1
                     /db_xref="GOA:Q1EMV4"
                     /db_xref="InterPro:IPR000043"
                     /db_xref="InterPro:IPR015878"
                     /db_xref="InterPro:IPR020082"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="catalyses reversible hydrolysis of
                     adenosyl-homocysteine"
                     /gene="flI"
                     /product="adenosyl-homocysteine hydrolase"
                     /protein_id="CAJ20010.1"
                     /transl_table=11
                     /translation="MAVVPSGSGAQRPVPEFKVADLSLAEFGRKEITLAEHEMPGLMAM
                     RAEYAGSRPLRGARVSGSLHMTVQTAVLIETLTALGASVRWASCNIFSTQDHAAAAVVV
                     GPHGTPEEPRGVPVFAWKGESLEEYWWCTRQALTWPEGGPQLIVDDGGDATLLVHLGVE
                     YEKAGAVPDPATAGSEEEAVILRLLAGTLREQPRLWTTVARDVIGVSEETTTGVHRLYE
                     RERDGTLLFPAINVNDSVTKSKFDNRYGVRHSLVDGINRGTDVLIGGKVAVVCGYGDVG
                     KGCAEALRGQGAKVTVTEVDPICALQAAMDGYPVATLEDMLPTADIVITATGNRDIVRV
                     EHMAAMKHLAIVGNIGHFDNEIDMAGLAGFPGIRRVNIKPQVDQWTFPDGHAVLVLSEG
                     RLLNLGNATGHPSFVMSNSFANQVIAQLELFTRAEEYPVGVHRLPKRLDEKVARLHLSA
                     LGARLTKLTKRQADYIGVPVEGPYKPDHYRY"
     gene            9802..10197
                     /gene="flJ"
     CDS             9802..10197
                     /codon_start=1
                     /db_xref="InterPro:IPR003793"
                     /db_xref="InterPro:IPR011322"
                     /db_xref="InterPro:IPR015867"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV3"
                     /gene="flJ"
                     /product="putative regulatory protein"
                     /protein_id="CAJ20011.1"
                     /transl_table=11
                     /translation="MEAPRPRPAGALRRLTVFTDLADRCAGRPRYAEIVRLGRQRGLRG
                     MSVLRGIGGYGRSGVVREGGLLRPPRDLPVMVVAVDTAEAIESFLPVLERIAPENLIVL
                     DEVRAVRFPAPGRGPGPDPLSRPGSSA"
     misc_feature    9928..9930
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10172..10591)
                     /gene="flK"
     CDS             complement(10172..10591)
                     /codon_start=1
                     /db_xref="PDB:3KUV"
                     /db_xref="PDB:3KUW"
                     /db_xref="PDB:3KV7"
                     /db_xref="PDB:3KV8"
                     /db_xref="PDB:3KVI"
                     /db_xref="PDB:3KVU"
                     /db_xref="PDB:3KVZ"
                     /db_xref="PDB:3KW1"
                     /db_xref="PDB:3KX7"
                     /db_xref="PDB:3KX8"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="catalyses hydrolysis of fluoroacetyl coenzyme A"
                     /gene="flK"
                     /product="fluoroacetyl coenzyme A thioesterase"
                     /protein_id="CAJ20012.1"
                     /transl_table=11
                     /translation="MKDGMRVGERFTHDFVVPPHKTVRHLYPESPEFAEFPEVFATGFM
                     VGLMEWACVRAMAPYLEPGEGSLGTAICVTHTAATPPGLTVTVTAELRSVEGRRLSWRV
                     SAHDGVDEIGSGTHERAVIHLEKFNAKVRQKTPAG"
     gene            complement(10696..11373)
                     /gene="flL"
     CDS             complement(10696..11373)
                     /codon_start=1
                     /db_xref="GOA:Q1EMV1"
                     /db_xref="InterPro:IPR000792"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR016032"
                     /db_xref="UniProtKB/TrEMBL:Q1EMV1"
                     /gene="flL"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 151.8; E-value:
                     2.5e-46)"
                     /gene_kind="regulatory"
                     /product="putative DNA binding regulatory protein"
                     /protein_id="CAJ20013.1"
                     /transl_table=11
                     /translation="MVTTIALCDPNLLIRGGLRAILAGEPDIEVVAEVADGEQALRTVR
                     RLRPDLLFTALDLPGGHGFEVARALARAPETRSTGVVFLAQSFDPALAVQGLMAGGRAF
                     VSTGDPPRRLVTAARAVAAGYAVLPPAVLADGPWLTGSGGAARPGAAPGVPGLTGRELE
                     VLRLMAAGMSNAEIAGHLSLGEATVKSHVSRLLGKLGLRNRSQAIACAYRTGLVTVPVP
                     GRG"
ORIGIN
        1 tgcgggaaga gcccttgccg ccgcttacgg catacacacg ggacgccaaa gaacgccgtc
       61 tggccggtca agacgcgact caaagcaacg caggtcctgg tcccgcctcg ggatcctcgg
      121 acggcatcac aacgagccca gacgggcacg ctccataagg tcgacaacat aatggaccag
      181 ttctaccggc gccgaagtac cggcgaagat cctgtggtcg actcctcgct caggatcgaa
      241 tctgccggtg tagatcaata cgggtacgtc gatgtggtat tgctcaagca gacggagcat
      301 tttgattccc gcctcgctgt cgccattccg atcgaagtcg ctgatgatga tgtcgtacgg
      361 tctccgccga agcagcggca cggcctcctc ggtggacagg gcgagttcta cgttcatgcc
      421 ggcggtccgg aagagttcga ccagcgggga gttgccctcc gggcggtcgt cgacccacag
      481 cacgttgcca ccccgcagca ggtcagcggc gtgttcgagc ctgcccaacg ccgtgcgcct
      541 ggcggtgggc gtgacggttg tcgggctctc ttcctgggcc tggtcgagca gttcacgtgc
      601 gagttcgagt tcgacaccca gcgcccgtac ggcagtcagc cggggcacca tgcgctgcac
      661 aatcgtctgc cgtagcgaga aatacacgac agcggcgaac cccacccaga ggatggccgg
      721 aagtgtctcg atcagcttga gccagatggc ggcgggcacg ccgacatgat ggacgacggc
      781 agccggacgc tgcattcact tcgggaaatt cggctcaagc gaggatgccc ccgcgcccgc
      841 tcagcacccc ccctcacccc acccccaaca accccggcaa ctccctcatc tcgcggaaca
      901 ccaccgtccc cgggcccctc agccgggcct ccggggtgac gccggaggcg taggcgaggg
      961 cggggatggc ggcggcgcgg gcggcttgga ggccgtggtg gctgtcttcg acgacgacgc
     1021 aggcggacgg ggggacgccc atggaggcgg cggcgtggag gaagaggtcg ggggcgggtt
     1081 tgccgtggcg gacatcggtg gcgctgtaga tgcggccggc gaagtggtcg tacaggccgg
     1141 tgcggcccag ggtgtggcgc atcttggcgt gggtgccgct ggaggcgacg caggtgggga
     1201 cggggatggc ggccagggcc tcggtgatgc cggggacggc ggtcagctcg gtgtcgacgg
     1261 cctcgcggtg cagcgcctcg aagcgccggc gccaggtggc ggcggccggg gcgccgaggc
     1321 gggcggctat cagctcgtcc accgaggcgt tggagcggcc cacgaagagg tcgacgacct
     1381 cgtcctcggt cagcggccag ccgagttcgg cgccgacggc gacatgggcg cggatggcga
     1441 gcggttcgct gtcgaccagg attccgtcgc agtcgaatat gaccagctgg ggcggcacac
     1501 gcatgccgca accctaggcc ctgtcgtcaa aaaatctcgc ctgccccgcg gggtccggca
     1561 cgcgcgctcg cggcgttgtc ggtcgtcggc ccgcacggtc gggctccgcc cgggggtacc
     1621 cccggacccc gcgggacacc gccctccggg cggccggcga tctcttgacg acagggccgg
     1681 cgccgctccc ccggcgcgtc cggcgccgcc gccctacagt ggtgcgggca ccagtaacca
     1741 ttccaccggt taccgaggga gcggccatgc gagcccgccg gacgggtacg gaacggacgg
     1801 gtacggaacg gcaaagagag cgggaacggg aacgggcgct cgcggtgggc gccggggggc
     1861 gggcgccggg gccgcggccc tgggtgcggg tggcgctggc gatgttcgcg gtggggtggg
     1921 gggccaacca gttctcgccg atgctgctcg tctaccacga gcagcggcgg ctgtcccagg
     1981 tggtgctggc ggcgatgttc ggctgctacg cgctcgggct gatccccgcg ctgctggtgg
     2041 ccgcggcgct gtcggaccgg atgggacggc ggcggttgat gcggccggtg ctgatcttgt
     2101 cgacggtggc ctcgctggtg ctggtcgccg gggcggtggc gacgccggcg ctcttcgcgg
     2161 ggcggctgct ggccggggtg gcctcgggga cggcgttcgc gccgggcagc gcgtgggtca
     2221 aggagctgtc ggcggacgcg cccgggggca gcggggcgcg gcgggcgacg gtggcgctct
     2281 ccgcggggtt cggcggcggg ccgctggtgg ccggggcggt ggcgcagtgg ctgccgtatc
     2341 cgcaggtgct gccgtatctg gtgcacatcg cggtgatgct ggtggtggcg ccgttggcgt
     2401 ggcgggcgcc ggagacggtg accccggggc ggcgggcggg cggtggtccg ggccgcggcg
     2461 gggtacgggc ggccgtggcc catccggtct tcctgcggac cgtggtgccg accgcgccgt
     2521 gggtgttcgc caccgccacg gtgggtttcg cggtactgcc ggggctggtg atacgcggcg
     2581 gtgacgggct ggtgctcagc ggggcgacgg cggggctggt gctgggcacc ggggtgctgg
     2641 tgcaaccgct ggcccggcgg gtggaacggt ggcgggcggg ggccgtgctg gtggccgggg
     2701 tgctggtggc ggcggccggg ctgctgctgg ccgcggtgac cgccgccacc gccgagccga
     2761 cgttgctgat cccggcggcc gtggtgctcg gggcggcgta cgggttgctg ctggtggcgg
     2821 ggctgggccg ggtgcaggcg ctggcgccgc cggaggacct ggccggggtg accgcggtct
     2881 tctactgcct gatctacctg gggttcgccg cgccgtacgt ggtggcggcg gccggcgccc
     2941 tgctctcccc ggcggcgttg ttctgcgtgg cggccggggc ggtgaccgcc accttgccgc
     3001 tgctgctggg taccggaggc gtccgggccc cgcgctgacc gccgggccgc cctcagccgc
     3061 gccgggcgaa ccccttgcgc agcagcgccg gcacctcctc ctcggggacc tgggccgcgg
     3121 cgagcggatc ggtcagcacg gcgccgtcca gcgcgtggtg gcaggcgcag tcggctgggg
     3181 cggtggcgtg ggcgaggccg gagagcacgg cgcgggcggc gatgacgttg gcggccatca
     3241 cctcggcgac ggtgcgggcg tccaccgagt cgtgtccggt gtgccagcag tcgtagtcgg
     3301 tgaccaacga cagcccggcg tagcacagtt cggcctcgcg ggcgagtttc gcctcgggct
     3361 gggcggtcat gccgatgacg tccatgcccc aggcgcggta cagctgggac tcggcccggg
     3421 tggagaactg cgggccctcc atgcacaggt aggtgccggc cgggtggacg gtggggtggg
     3481 cggcccgggc ggcgtcggtg agggcggcgc gcagccgggg gcagtagggg tcggccagcg
     3541 agacgtggac gacgacgccg gaggagaaga aggtcgcggg ccggccgccc cgggtgcggt
     3601 cgatgatctg gtcggggacg acgaggtggc cgggggcgta ctcctcgcgc aggctgccga
     3661 ccgcgctgac gctgacgacc tcggtgaccc cgagcgcctt gagcgcgtag aggtttgccc
     3721 gcaccgggat gcgggagggc ggtatgcggt ggccggtgcc gtggcgggcc aggaaggcca
     3781 cccagcgtcc gccgacggtg ccgacgaccg gcggtgcgct gggcgggccg tacggcgtct
     3841 cgaccgggaa ttcctcgggg tcggtcaggc ccgggaattc gtacagtccg ctgccgccga
     3901 tgatgccgag atcggcgttc cgctgctcgt tccccgattt ccgtgcccgc atgcgcgcac
     3961 ctccggtcgt agctgatcgc ggatccgcgc aatctaacag gcggcggctg cgggcgacag
     4021 cgccggaatt cgcaacctgt gccggggaac catgccgact acacccttcg gtgcagggtt
     4081 ggtgtgccct tgggccgatt tcccttgtcg ttcccggcat ttatggtcga tcgggtctga
     4141 tccaccagga gcgatcgcag gaggaattca cgtggctgcg aacagcacac gtcgccccat
     4201 catcgcgttc atgagcgacc tggggaccac ggacgactcc gtcgcccagt gcaaggggct
     4261 catgtacagc atctgcccgg acgtcacggt ggtggacgtc tgccactcga tgacgccctg
     4321 ggacgtcgag gagggcgccc gctacatcgt ggaccttccg cgcttcttcc ccgagggaac
     4381 ggtcttcgcc accaccacct atccggcgac cggcaccacc acccgctcgg tggcggtgcg
     4441 catcaagcag gccgccaagg gcggtgcccg cggccagtgg gcgggctcgg gggccggctt
     4501 cgagcgcgcc gagggctcgt acatctacat cgcgcccaac aacgggctgc tgaccaccgt
     4561 gctggaggag cacggctacc tggaggcgta cgaggtcacc tcgccgaagg tcatccccga
     4621 gcagcccgaa ccgaccttct acagccggga gatggtggcc atcccctccg cgcacctggc
     4681 cgccggcttc ccgctgtccg aggtcggccg tccgctggag gaccacgaga tcgtccgctt
     4741 caaccgcccg gccgtcgagc aggacgggga ggcgctggtg ggcgtggtct ccgccatcga
     4801 ccacccgttc ggcaacgtgt ggaccaacat ccaccgcacc gacctggaga aggcgggcat
     4861 cggctacggc gcccggctgc ggctgacgct ggacggcgtg ctgccgttcg aggcgccgct
     4921 gaccccgacg ttcgccgacg ccggtgagat cggcaacatc gccatctacc tcaacagccg
     4981 cggttacctg tccatcgcgc gcaacgcggc cagcctcgcc tacccgtacc acctcaagga
     5041 gggcatgtcc gcccgggtcg aggcccgctg acccccttcc ggccgtcccg tccgcgccgg
     5101 cgggcggggc ggccggaacg cgcgacgacg taccctcgtg cggcgtgagg gacggcgtgg
     5161 cggacggtgt ggcgggacgg gtacgggggc gcgggatgga gcgggccgag ggggtcgggg
     5221 tgaccgtcgg tgcgcaggtg cgccggctgc gggagttccg cgggctgtcg gtggcggagt
     5281 tgtcccggct gtcgggggtg agccgggcga cgttgtcgat gctggagtcg gggcggggca
     5341 acccgacgat cgagacggtc tcggcgatcg cggtggcgct gcggctgccg ctgggcgatc
     5401 tgctggtgga ccccaccccg ccggagccgg tgctgcggcc gggcacgccg cgtccgcaga
     5461 ccagccggca ggacctgctg gaccggatcg gggcgggcgg gcacagcgag atatggcggc
     5521 tgcggctgtg cggggcgggc cgccgggtcg acagcccgcc gcacacccgc ggcaccctgg
     5581 agcgggtggt ggcgctgcgc ggccggctgc ggctgggccc ggtggaccgc ccggtggtgc
     5641 tggccaccgg tgacttcgtg gtcttcccgg cggacgaacc gcacttctac gaggcggtgg
     5701 acgacgagga cgtggacgcg gtgatcgtga tgacctatcc ggcggcgtcg taggccctgt
     5761 cgtcgaaagg tcgccgcccg cccggagggc ggtgccccgc ggcttccacg ggggtccccc
     5821 caggtgaggc ggagcccgac cgtgcgggcc gacggccgac aacgccgcga gcgcgcgggg
     5881 cagacgtcgc ggggcagacg tcgcggggca gacgtcgcgg ggcaggcgac atgttgacga
     5941 cagggcctag gccaggtcgt agtcggtgat cggtaccggg gtgcggacca tgccgcgttc
     6001 caccgccttg cggacggcct cggtgcggca ggcggcgtcc aacttggcgt agacgttgga
     6061 cagatggcgt ttgacggtgc cctcggtgat gaccagttcg cgggcgatct gtgagttgcg
     6121 caggcccctg gcgaccaggg cgacgacctg gagttcgcgg gcggtcagca ggtgcgggcc
     6181 ggtctcgcgc agcccggcca gggtgcgctg ggagaccgag agcaccaccc ggtcgcggtg
     6241 gccggccacc ccgcggatgg tgccgatcag ttcctcgggg ctgctgtact gggcgatcgc
     6301 ggcctgggcg ccggccgcca ggagtctgcg gaccgcgccg gggtcgtcgt gggcgagcat
     6361 cgccacgatc cggctgaccg gggtggcccg gcgcaactcg gcgacgtcgc cgtagggttc
     6421 ccggccgccg gaggcgacgc cgagcagcac gacgtggggc tggcgggcgc gcagcgcgga
     6481 gagcccctcg cgtacgtggg ccgactcggc gactacttcg agggcgggtt cggcggcgag
     6541 cacgtgggcc agtccggtgc gcaggaagac gttgtcgtcg acgacggcga gccggatcgc
     6601 cgcctgctgc cggcggactg cggccgtcgc ggcgccgcgg tggagggtca tgcggtttcc
     6661 gcctttcgcc tggtggtctc ggggtccggc gtcccccgtt caccgccggt cggtcggcgt
     6721 tgcgacatca gcgggcggtg gcggcgcacg gtgcggccga gccagacgcc cgcggcctgg
     6781 gaggtgacga tggagagcac caccaggctg gtgaagaagt cctcgctgat gacgccggcc
     6841 gcgtaggtga ccgacgccag gatgatgccg gggccgccgc gggcgttcat ggccaccgcg
     6901 atgttcccgg ccgacgcggc gtcctgcccg gccaaccgtg cccccgccca caccccggcc
     6961 gacttgacca cgcaggccag cgccaggaac cacaggaaga acaccgggtc gaagtggcgg
     7021 atcaggtcga gcttgaggcc gacgacggcg aagtagacgg ggacgaagaa ggcgagcgag
     7081 atggcccgca gggtctggta cgaccccggg gcggcgtccg cggcggcctc cggcacggcg
     7141 ggcgccgcgc gttcctcgcc gggcaccggg ccgccggcgc tcagcccggc cgccagcgcg
     7201 ccgaacatcg ggtcgatgcc gaggccggag caggccaggc agagcgcgaa gaggtaggcg
     7261 atccggaacg cggtcgggct gcgccgttcc aggacgttcc agcggccgga gcgcagcgcg
     7321 tcgaaggcgg cccggccgcg ccacaggaag agcccgaaga agaccaccgg gacgagggag
     7381 aagaagacca ccgcccacgg cagcgacacc cggctgagcg ccccgccgac gccgtaggag
     7441 tcgcccgccc tggcctgggc gatgccgagg acgacggcga gcagcgcgta gagcaccacg
     7501 tcctccagga ccgcgacggc gagcaccacg cgggcgaaga cggtgcgcag gatgcccagg
     7561 tcgagcatga tccgggagat caccgggacg ctggtgacgg cgatcgccat gccgaagacg
     7621 agggcgaggc tggccgggtt gccgtgcggc ccggaaaggc cgggcaggga tacggagttg
     7681 gccaccagca gcccggcggc gaacgggacg aagaggccgg cgccggccac ccagaccatg
     7741 gtgcgccggt cggagcgggc gacgtggccg cgcagttcgg cgccggtgag gtagaccagc
     7801 agcagcatcc cgatgctgta gaaggcgccg agcacctcgc cggtggcgcc cttggccggg
     7861 aagagccacg tctcggcggt gggccacagc gcgccgagca cggtggggcc cagcaccagg
     7921 ccgccgacga tctcaccgat caccggtggc tgccgcaaca gttggaagat ctgggcgccg
     7981 gcgtgggcca gcaccgtcaa cagcccgagg gcgatgagga catgggcgag ttcgacggtt
     8041 gtcagggaca ccgggcacct cccgaaggcc gggccgaaac cgcatcaggt gaattcctat
     8101 cggagcggtt cgccggtgtc catcgcccgg tcggctattc cttgcgggct ttccgttccg
     8161 ccgtgcggat tccgtctccg ggtggagttc gcggggcgtt caccacctgg cggcggaggg
     8221 cgactttccg catcgcgacg gatgcgccag ggcaccggtc gcggcaggct ggcccggaca
     8281 accacacagg caccaccggc agtcgaaggc tggagcatgg cagtcgtacc atccgggtcc
     8341 ggggcgcagc ggccggttcc ggaattcaag gtggccgatc tttccctggc ggaattcgga
     8401 cgcaaggaaa tcacgctggc cgagcatgaa atgccggggc tgatggcgat gcgggcggaa
     8461 tacgccggga gccggccgct gcgcggggcg cgggtcagcg gttcgctgca catgacggtg
     8521 cagacggcgg tgctgatcga gacgctgacc gcgctgggcg cctcggtgcg ctgggcgagc
     8581 tgcaacatct tctccaccca ggaccacgcc gcggcggccg tggtggtggg cccgcacggc
     8641 acccccgagg aaccgcgcgg ggtgccggtg ttcgcgtgga agggggagag cctggaggag
     8701 tactggtggt gcacccggca ggcgctgacc tggccggagg ggggcccgca gctgatcgtg
     8761 gacgacggcg gcgacgccac cttgctggtg cacctggggg tggagtacga gaaggcgggc
     8821 gcggtgcccg acccggccac cgccggctcg gaggaggagg cggtgatcct gcggctgctc
     8881 gccggcacgc tgcgcgaaca gccgcggctg tggacgacgg tggcccggga cgtcatcggg
     8941 gtctcggagg agaccaccac cggggtgcac cggctctacg agcgggagcg cgacggcacg
     9001 ctgctgttcc cggcgatcaa cgtcaacgac tcggtgacca agtcgaagtt cgacaaccgc
     9061 tacggggtgc gccactcgct ggtggacggg atcaaccggg gcaccgatgt gctcatcggc
     9121 ggcaaggtgg cggtggtctg cggctacggg gacgtgggca aggggtgcgc ggaggcgctg
     9181 cgcggccagg gcgccaaggt gacggtgacc gaggtcgacc cgatctgcgc gctccaggcg
     9241 gccatggacg gctacccggt ggccaccttg gaggacatgc tgcccaccgc ggacatcgtg
     9301 atcaccgcca ccggcaaccg ggacatcgtg cgggtggagc acatggccgc gatgaagcac
     9361 ctggcgatcg tgggcaacat cggccacttc gacaacgaga tcgacatggc cgggctcgcc
     9421 ggcttcccgg ggatccgccg cgtgaacatc aagccgcagg tggaccagtg gacgttcccg
     9481 gacggccacg cggtgctggt gctcagcgag ggccggctgc tcaacctggg gaacgccacc
     9541 gggcatccga gcttcgtgat gtccaacagc ttcgccaacc aggtgatcgc gcagctggag
     9601 ttgttcaccc gggccgagga gtacccggtg ggcgtccacc ggctgcccaa gcggctcgac
     9661 gagaaggtgg cccggctcca cctgtcggca ctgggcgccc ggctgactaa gctgaccaag
     9721 cgtcaggccg actacatcgg ggtccccgtg gagggcccgt acaagccgga ccactaccga
     9781 tactgagggg ggacgcccgg gatggaagcg ccccgtcccc ggccggccgg cgcgttgcgc
     9841 cgcctgaccg tcttcacgga tctggccgac cggtgcgcgg ggcgcccgcg gtacgccgag
     9901 atcgtccgcc tcggccgtca gcgcgggtta cgcgggatga gcgtgctgcg cggcatcggc
     9961 ggctacggcc gctccggggt ggtgcgcgag ggcgggctgc tgcgcccgcc ccgcgacctg
    10021 ccggtgatgg tggtggcggt ggacaccgcc gaggccatcg agtcgttcct gccggtgctg
    10081 gagcggatcg cgccggagaa cctgatcgtg ctggacgagg tgcgggcggt gcgcttcccg
    10141 gcgccggggc gcgggccggg gccggatccg ctcagccggc cggggtcttc tgcctgacct
    10201 tggcgttgaa cttctccagg tggatcacgg cgcgctcgtg ggtgccggag ccgatctcgt
    10261 ccaccccgtc gtgggcgctg acccgccagc tgagccgccg tccctcgacc gagcgcagtt
    10321 cggcggtgac ggtgacggtc aggcccggcg gggtggcggc ggtgtgggtg acgcagatgg
    10381 cggtgccgag gctgccctcg ccgggttcga ggtagggcgc catggcccgc acgcacgccc
    10441 actccatcag ccccaccatg aacccggtgg cgaacacctc gggaaattcg gcgaattcgg
    10501 gggactcggg gtacaggtgg cgcaccgtct tgtgcggcgg gaccacgaag tcgtgggtga
    10561 accgctcgcc gacccgcatg ccgtccttca tgggccactc ctcactggtg ccggggcgaa
    10621 gggaccgatc tcgccgttcc catggtgccc cgggggcccg ctccggcggt ggctttccgg
    10681 ccgggtggcg gccggtcagc cccggccggg gacggggacg gtgaccagtc cggtgcggta
    10741 ggcgcaggcg atggcctggg agcggttgcg caggcccagt ttgcccagca ggcgggagac
    10801 gtgggacttg acggtggcct cgccgaggga gaggtggccg gcgatctcgg cgttggacat
    10861 cccggcggcc atcagccgca gcacctccag ttcgcggccg gtcagcccgg ggacgccggg
    10921 ggcggcaccg ggccgggcgg cgccgccgga tccggtcagc cacggcccgt ccgccagcac
    10981 cgccgggggc agcacggcgt acccggcggc caccgcgcgg gccgccgtca ccaggcggcg
    11041 cggcgggtcg ccggtggaga cgaaggcccg gccgccggcc atcagcccct gcaccgccag
    11101 cgccgggtcg aagctctgcg cgaggaagac caccccggtg ctgcgggtct ccggggcgcg
    11161 ggcgagggcg cgggccacct cgaagccgtg gccgccgggc aggtcgaggg cggtgaagag
    11221 caggtcgggg cggagccgcc ggaccgtccg cagcgcctgt tccccgtcgg ccacctcggc
    11281 gaccacctcg atgtccggct cgccggccag gatggcgcgc agcccgccgc ggatgaggag
    11341 gttggggtcg cacagcgcga tggtggtcac catgggtccc tccggacgag ggcgggggcc
    11401 gggcctggcc cggaggtggc atccgccgta cgccaagtgg tgtacacacg gcgtgccatg
    11461 gcgaatatgc cgtaagcaac agagggccac aacgcgcatt ccggacagtc tcggcggtcc
    11521 cggcctcccc agccggtggc ccgtgccaca gccgccgtgc cccgcgcgcc ggtgacgacc
    11581 gcccgacgag cgggtatccg ccctgtgcgg gggagcgtgc cggtggcgtg ttccggaccg
    11641 ttccggccgg gccgggacgg cggggcgggc ccggctcggc gatgctgtgg acgccggacc
    11701 ggaaccgtcc gtgacgacac cggaaggttg cccttcccga tcggccgtga ccgcggtacg
    11761 tccccaacat gaccggccac cgctgtccgc cgtgcggggt cccccacgcc gaaggcggaa
    11821 gtacccgatg agcgctcgca aaccgttgtc gtgggtcgcc gccgtgctcg accagctcac
    11881 cgaccggctg gcgggcgcgg ccggcggcca tccggcggcc tggggcgggg ccgaccggcg
    11941 tccgcccagc ctcggcgaac tcgacctgca tttgatcggc cgcggccggc acgagcggct
    12001 gtg
//
