LOCUS       BGC0000904             15076 bp    DNA     linear   BCT 03-OCT-2008
DEFINITION  Streptomyces rubellomurinus FR900098 biosynthetic gene cluster,
            complete sequence; and dxrB (dxrB) gene, complete cds.
ACCESSION   BGC0000904
VERSION     BGC0000904
KEYWORDS    .
SOURCE      Streptomyces rubellomurinus
  ORGANISM  Streptomyces rubellomurinus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:24:23
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..15076
                     /db_xref="ATCC:31215"
                     /db_xref="taxon:359131"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces rubellomurinus"
                     /strain="ATCC 31215"
                     /type_material="type strain of Streptomyces rubellomurinus"
     protocluster    1..15076
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5273:6104]"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5274..6104
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="1"
     protocluster    1..15076
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3900:11339]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      3901..11339
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="2"
     cand_cluster    1..15076
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /detection_rules="(LmbU or Neocarzinostat or bcpB or frbD
                     or mitE or vlmB or prnB or CaiA or bacilysin or
                     orf2_PTase)"
                     /kind="chemical_hybrid"
                     /product="phosphonate"
                     /product="other"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..15076
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000904"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15076
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /product="other"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /rules="(LmbU or Neocarzinostat or bcpB or frbD or mitE or
                     vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(117..2777)
                     /gene="frbA"
     CDS             complement(117..2777)
                     /codon_start=1
                     /gene="frbA"
                     /product="FrbA"
                     /protein_id="ABB90390.1"
                     /transl_table=11
                     /translation="MRDLLRDLRLPDRNARYVSLAAAEEMGLVGISSAPRSLRVLVENT
                     LRAAAAAKAGSTGDSLRQAVLSANSLIAAATANGPVSEVEFRPTRLVLQDHSGIPVLAD
                     LASLRSIMADRGLDPRLARPALPVDLVVDHSVEVASWARPDALSLNMRREYELNGERYR
                     FLRWAQQEISGLRVVPPGRGIVHQMHLEHLARVVLPDGDGLIAPDTVLGTDSHTPMVGA
                     LGVLGWGVGGIEAETVLLGHSVSLLSPQVIGVRLTGELPVGSTATDLALTMTEFLRNVG
                     VVGRFVEFFGPGVCALSVPDRATLSNMAPEYGCTVAFFPVDDTTLRYLELTGRGAEEIR
                     LVEAYCKEQGLFAGADASADPEFARVLDFDLSAVEPSAAGPRRPQDRLPLGTVPASFPE
                     PSGAALAGAAEGRRELADGAVAIAAITSCTNTANPHSMVTAGLVARKAVQRGLAVPSWV
                     KTSLAPGSRAVVHYLEAAGLLPDLEKLGFSVAGFGCTTCIGNSGGLAPEAEERARTEGV
                     RLAAVLSGNRNFEGRIHPDVAAAYLASPALVVAYALAGTVLTDLTARPVGTDPDGAEVF
                     LADLWPTPEEIDAAVGLVAREHFASEKESLFTGGPEWTSLEHPSGPVYDWPAESDYLLR
                     SPFFDGLTHAPLSDLSGARVLVLTGDSTTTDHISPAGAIGADSPAGRYLRALGVEPALF
                     NSYGCRRGNHEVLVRGTFANPKFRNLLTPDVQGSSTLHVPTGERMSVHEAALAYAAEQV
                     PVVVVGGRDYGFGSSRDWAAKGPALLGVRAVLAKSFERIHRSNLIGMGIVPLEFLPDQD
                     AGTLGLTGHEALDVIGLDGLVPRGTVTVRARSAEGEPVAEWRMLARVDTAGELEYVRRG
                     GFLRSVASDLLDAEA"
     misc_feature    117..12985
                     /note="FR900098 biosynthetic gene cluster"
     misc_feature    complement(2763..2765)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2826..3884
                     /gene="frbB"
     CDS             2826..3884
                     /codon_start=1
                     /gene="frbB"
                     /product="FrbB"
                     /protein_id="ABB90391.1"
                     /transl_table=11
                     /translation="MTVSQYPDVAVRSDSPRPEASVLPAALELLESAGLTANWRIVAGQ
                     APDGDGGRKPEAGLLPPFAEPGASAYGLARAARRAWGGTFSVIERRGPLVRSDGTVNVL
                     LFRYELDMSDTGMEFESNSGEQLALVKTAAELGPREIPEQAALGIQAIAPDRVSEFVRT
                     AVGMCRRLDVDDLVVAHKGNSIKHTDGLFALTAAETLESLAGAAGIAWRSLIIDHMAAE
                     LVRNPLDYRAILTHSSFADLLAAALAGQMTTDQLGVCTTYDPAGRPLFGHDPALDTSAP
                     DADPERWRVRRLASTLAAGAALAEHLRLPPAGRALRRAAAELVRRDGGPIGWDQAVTTA
                     RKSLRAEGPARS"
     gene            complement(3901..5022)
                     /gene="frbC"
     CDS             complement(3901..5022)
                     /codon_start=1
                     /gene="frbC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 331.6;
                     E-value: 1.4e-100)"
                     /gene_kind="biosynthetic"
                     /product="FrbC"
                     /protein_id="ABB90392.1"
                     /sec_met_domain="HMGL-like (E-value: 1.5e-74, bitscore:
                     240.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNDLVLEDTTLRDGEQTPGVAFSKETKTAILNALIEAGVTSIEI
                     GIPAMGGEELDFIKSVVDRQDEARLVVWHRGVREDVERSLDLGFTSVHVGLPTSAGHLK
                     ASVRKDRTWLLATARDMVKMAKDRGAFVSISAEDIARTEISFLQEYAGVVAEAGADRLR
                     LSDTVGLLGPEAYGERVAAVLSAADIDVQCHAHNDFGLATANTLAGLKAGARYFHVTVN
                     AIGERAGMADLAQVVVALKKLYDRDLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNV
                     FAHESGIHANGMFRDTSSFEPFPPEHVGGERRYVLGKHSGRALVAWALEQEGITPREEL
                     LPHCLEEVRALSIRIGGAVSHEQLVEIYNKAAA"
     misc_feature    complement(5008..5010)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5274..6104
                     /gene="frbD"
     CDS             5274..6104
                     /codon_start=1
                     /gene="frbD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters) other:
                     frbD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 247.1;
                     E-value: 3.7e-75)"
                     /gene_kind="biosynthetic"
                     /product="FrbD"
                     /protein_id="ABB90393.1"
                     /sec_met_domain="frbD (E-value: 6.3e-184, bitscore: 598.7,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 7.4e-115,
                     bitscore: 372.1, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.4e-103, bitscore:
                     335.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 4.8e-65, bitscore:
                     208.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKRTMLRRAIARGGMSIAAGVHDGLSARIAQDAGFDVLWASGLG
                     ISAAHAVPDDSILTMTEFLEAARVMNDSTDLPVLADCDTGFGDERNVARMVERYERAGI
                     AGVCIEDKVFPKRNSLGDGAQDQETIEGFAAKLAAAKKAQQTDDFVVVARIETFIAGGV
                     KEDAIARADAYVAAGADAILIHSKSRDGLEILDFGRSWQRKDVPLVAVPTTYPAVTADD
                     LHEAGFSLAIYANQALRASITSMRESLRQITHDRSSLRIEPKVAKLSEVFELQR"
     misc_feature    5292..5294
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6192..7289
                     /gene="frbE"
     CDS             6192..7289
                     /codon_start=1
                     /gene="frbE"
                     /product="FrbE"
                     /protein_id="ABB90394.1"
                     /transl_table=11
                     /translation="MRKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRPAG
                     QGALRSVGELLPASTLDSIRRNGVALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVR
                     VWPGAGAVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLK
                     PITPGGSRRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTA
                     TVPVTVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDRTAVFEA
                     THGSAPEFAGSNRLNPTALILSGCMLLDHLGEAPTAARIRAAVRSVLEEGRSVTFDLLP
                     PDRAARAVTTTAYAEAVIERLRDIG"
     gene            7286..8146
                     /gene="frbF"
     CDS             7286..8146
                     /codon_start=1
                     /gene="frbF"
                     /gene_functions="resistance (resist) AAC3 (Score: 196.7;
                     E-value: 2.5e-60)"
                     /gene_kind="resistance"
                     /product="FrbF"
                     /protein_id="ABB90395.1"
                     /transl_table=11
                     /translation="MIRHIDARREDLEPDRQDRELVTRDRLASDLAALGVRPGGVLLVH
                     ASLSALGWVCGGAQAVVLALQDAVGKEGTLVMPTFSGDLSDPSTWRRPPVPEDWWPVIR
                     EQMPPFDPDLTPTRGMGAVAECFRRAAGAVRSGHPQNSFAAWGAHAEQVVAEHGLTERL
                     GRGSPLEQVYRLDGQVLLLGCGFESNTSFHLAEYRTAYPGRRSHRRRVPVPEGDRVRWV
                     EQEDIVYFEEDFQTMGESCLTRTPGHSRGTVGEAAAVLYGQRAFVDLACEWMTAHRDLA
                     RAVGA"
     gene            8143..9456
                     /gene="frbG"
     CDS             8143..9456
                     /codon_start=1
                     /gene="frbG"
                     /product="FrbG"
                     /protein_id="ABB90396.1"
                     /transl_table=11
                     /translation="MTHYATVICGGGPAGVSAVVAAAVQGRLEEFLDRGVLLVEATGRA
                     GSGSIPHYGIRANSLGSAFLECLDGPAGSGLLAGLADSAEARELRGWADEYPPLPVVGA
                     FLTLVGERVVDALRRHPRCDALLGHRVVEVRTGPERATVLLSGPDGELSHTGDRVLLTM
                     GGRERTELAPDALAALVERRPGLRVLSSGEVITDPSWHPDAASPHRALGSIAVLGGAHS
                     AWAVAAHLARLARAGWFAGPVEVTVVERRLPPIFYFSAAEARAEGYRWDEADVCGPSGR
                     VHRFGGLRGPARELARQVMGLAAEKAPDGFGQVVLDGPWTAEALEAAVGDADLVITALG
                     YDARLPRLLGADGRELELARPRGAVDTGRDGLPGLAAGGRAERLVMYGLGAGLVPSEET
                     GGEPGYRGRLDGVWVYQHDIGAVILRALLANDRTEDGR"
     gene            9453..11339
                     /gene="frbH"
     CDS             9453..11339
                     /NRPS_PKS="Domain: Aminotran_1_2 (326-606). E-value:
                     5.8e-23. Score: 73.4. Matches aSDomain:
                     nrpspksdomains_frbH_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="frbH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 83.9; E-value: 1.8e-25)"
                     /gene_kind="biosynthetic"
                     /product="FrbH"
                     /protein_id="ABB90397.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.6e-22, bitscore:
                     69.4, seeds: 297, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.2e-23, bitscore:
                     73.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENRTFATPDAVPVRAVVLAAGLGSRLGEPSSRRPKPLTPVAGR
                     PILAHTLGHLAGVGVQEVVLVVGHLREAVRELAGGEYAGMKIHYVVNPDPSTTNNLRSV
                     RLAREFLDQDVFLLEGDVVFEPAVLERLAAAPEASAVAASRPLRPLAGTVVRADADGVL
                     TDYVDDRRQAGAFDHPGALKTANLYLLREAFLRERFLPALEELDRRLAGQGYYDYAVSD
                     GLAAGGHAWRVADISDLAWYEVDDPGDQRQADFRFSPPREQQRILESLHGGYWRYGVTD
                     HALLYNVHFPPAEMMEILRSDFDAVLRNYPSAHAPLTELAATIAARRPEEVVLANGSSE
                     IIKILARLRGNWTVPVPGFNEYENVVGAERVHRYQLDAPDFRLPVEDYAAFVRRSGVDT
                     AVVVSPNNPTSVGVPLADLRRLADLVGPDVLLVIDESFVDFAPAPIASIGPFLDRHRNV
                     LLLKSISKVYGVGGIRLGYAATADTELARTLRAELPIWDINGFAEEFLRVLPHFRRAFA
                     DSCRQMRQNTLALAEGLAALPGIRVVPPDANFVFVELTGGIRAPELAHELFRRFRILTK
                     ECSGKSMPGGDAYLRVSSRSRAENEVVVAAVAEIVGGPRGAATTEGAGRADG"
     aSDomain        10431..11270
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_frbH_Aminotran_1_2.1"
                     /evalue="5.80E-23"
                     /label="frbH_Aminotran_1_2.1"
                     /locus_tag="frbH"
                     /protein_end="606"
                     /protein_start="326"
                     /score="73.4"
                     /tool="antismash"
                     /translation="RRPEEVVLANGSSEIIKILARLRGNWTVPVPGFNEYENVVGAERV
                     HRYQLDAPDFRLPVEDYAAFVRRSGVDTAVVVSPNNPTSVGVPLADLRRLADLVGPDVL
                     LVIDESFVDFAPAPIASIGPFLDRHRNVLLLKSISKVYGVGGIRLGYAATADTELARTL
                     RAELPIWDINGFAEEFLRVLPHFRRAFADSCRQMRQNTLALAEGLAALPGIRVVPPDAN
                     FVFVELTGGIRAPELAHELFRRFRILTKECSGKSMPGGDAYLRVSSRSRAENEVVVAA"
     gene            11353..11973
                     /gene="frbI"
     CDS             11353..11973
                     /codon_start=1
                     /gene="frbI"
                     /product="FrbI"
                     /protein_id="ABB90398.1"
                     /transl_table=11
                     /translation="MRWLGRGERVVHDSRFLTVSVADVELPGGETVEHHFVRAPGAAII
                     VVQDERQRILMMYRHRFVSDLWGWELPGGLVDDREDPAVTAAREAEEETGYRPRNVRHL
                     LTYQPMAGMVDSPHHIYLADGADLVGGPTECTEAQETRWMPLDEAAELLRSGRTVTSGT
                     AIGLLAVLGLGGARQQPGGVQEQPGGAQQQGMNESHSGRTVRG"
     gene            11966..12985
                     /gene="frbJ"
     CDS             11966..12985
                     /NRPS_PKS="Domain: TauD (72-311). E-value: 9.2e-32. Score:
                     102.7. Matches aSDomain: nrpspksdomains_frbJ_TauD.1"
                     /codon_start=1
                     /gene="frbJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /product="FrbJ"
                     /protein_id="ABB90399.1"
                     /sec_met_domain="TauD (E-value: 1.8e-32, bitscore: 102.7,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEILKKPVTGRSVWQRAQVEDASQWTYVLDEGMRAEILEAAERI
                     NEQGLTVWDLDRKAVPLERAGKLVAQCVEQLEHGFGLAMLRGVPTEGLTVAESQVVMGV
                     VGLHLGTAVAQNGHGDRVVSIRDYGKGRLNSKTIRGYQTNESLPWHSDAPDIAALLCLT
                     QAKHGGEFHVASAMHIYNTLLQEAPELLGLYYAGVFFDYRGEEPPGEPPAYRNAIFGYH
                     NGQLSCRYFLRNFADSGTAKLGFEQPEVEKLALDTFEEIASRPENHVSMRLEPGDMQLV
                     DDNVTVHRRGAYSDEEDGSTDSSRHLLRLWINVENGRQFPTSLSTHRWGMKAAAKPTH"
     aSDomain        12182..12898
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_frbJ_TauD.1"
                     /evalue="9.20E-32"
                     /label="frbJ_TauD.1"
                     /locus_tag="frbJ"
                     /protein_end="311"
                     /protein_start="72"
                     /score="102.7"
                     /tool="antismash"
                     /translation="VEQLEHGFGLAMLRGVPTEGLTVAESQVVMGVVGLHLGTAVAQNG
                     HGDRVVSIRDYGKGRLNSKTIRGYQTNESLPWHSDAPDIAALLCLTQAKHGGEFHVASA
                     MHIYNTLLQEAPELLGLYYAGVFFDYRGEEPPGEPPAYRNAIFGYHNGQLSCRYFLRNF
                     ADSGTAKLGFEQPEVEKLALDTFEEIASRPENHVSMRLEPGDMQLVDDNVTVHRRGAYS
                     DEEDGSTDSSRHLLRLW"
     gene            13088..14341
                     /gene="dxrB"
     CDS             13088..14341
                     /codon_start=1
                     /gene="dxrB"
                     /product="dxrB"
                     /protein_id="ABB90400.1"
                     /transl_table=11
                     /translation="MTGRHGIRDTLTIVTSLSNDPRSVVILGSTGSIGTQAIDVIQRNR
                     ARFRVRALSAGGGNLSLLAAQALDLEVEQVGLADSGAVEDFRAALRDEAAKRGLKSGDF
                     KLPDLLHGPEASTELAALPCDSVLNGITGSVGLEPTLAALKSGSRLILANKESLIVGGP
                     LVKKVAAPGQILPVDSEHSALFQCLQGGKEQDVRKLVVTASGGPFHGRGRAEMAAVTPE
                     QALAHPVWNMGPVITINCANLVNKGLEVIEAHLLFDIPFSRIEVVVHPQVMVHSMVEFT
                     DGSTLAQVSPPDIRLPLSLGLGWPDRVPDAAPSCDWTKASTWEFFPVDGDAFPGVQLAY
                     EVGEAGGTVPAVFNAANEELVAAFVAGRLPFLGIVDTLGKIVGEHDRVPNEAMTLEAIA
                     EADRWARARAKELVGLSD"
ORIGIN
        1 ctgaccaccg gtccgcgcgg ggcgccgccc ggtgggtggt gtcgggtggt tcgtcggccc
       61 ggacgcggcc ggagcaccgg aggcccggcc ctccggccgc gtccaggggc ggacggtcag
      121 gcctcggcgt cgagcaggtc cgacgccacc gagcgcagga acccgccgcg gcggacgtac
      181 tccagctcgc ccgcggtgtc cacccgggcc agcatccgcc attcggccac cggctcgccc
      241 tcggcggagc gggcccggac ggtcacggtg ccgcgcggca ccagcccgtc cagcccgatc
      301 acgtccaggg cctcgtgccc ggtgaggccg agcgtcccgg cgtcctggtc gggcaggaac
      361 tccagcggga cgatgcccat cccgatcagg ttgctgcggt ggatccgctc gaagctcttc
      421 gcgagcaccg cccggacgcc cagcagcgcc gggcccttgg cggcccagtc ccgggagctg
      481 ccgaagccgt agtccctgcc gccgacgacc acgaccggga cctgctcggc ggcgtaggcg
      541 agcgcggcct cgtggacgct catccgctcg ccggtgggga cgtgcagggt gctgctgccc
      601 tggacgtcgg gggtgagcag gttgcggaac ttcgggttgg cgaaggtccc ccggaccagc
      661 acctcgtggt tgccgcgccg gcagccgtag gagttgaaca gcgccggctc cacgccgagc
      721 gcccgcaggt agcgcccggc gggcgagtcg gccccgatgg cgccggccgg ggagatgtgg
      781 tccgtcgtgg tggagtcgcc ggtgagcacc aggacgcggg ccccggacag gtcggacagc
      841 ggcgcgtgcg tcagcccgtc gaagaacggg gagcgcagca ggtagtcgga ctcggccggc
      901 cagtcgtaca ccgggccgga ggggtgctcc agggacgtcc attcggggcc gccggtgaac
      961 agcgactcct tctccgacgc gaagtgctcc cgggcgacga gcccgaccgc cgcgtcgatc
     1021 tcctcgggcg tgggccacag gtccgcgagg aagacctcgg cgccgtccgg gtcggtgccg
     1081 acgggccggg ccgtcaggtc ggtgagcacc gtcccggcga gggcgtacgc gaccaccagg
     1141 gccggcgagg ccaggtaggc cgccgcgacg tccgggtgga tccggccctc gaagttgcgg
     1201 ttgccggaga gcaccgccgc cagccggacg ccttcggtgc gggcccgctc ctcggcctcc
     1261 ggggcgaggc cgcccgagtt cccgatgcag gtggtgcacc cgaaacccgc caccgagaag
     1321 cccagcttct ccaggtcggg gagcaggccg gccgcctcca ggtagtggac gacggcacgc
     1381 gagcccggcg ccagactggt cttcacccag gacgggacgg ccaggccgcg ctgcacggcc
     1441 ttcctggcca ccagaccggc ggtcaccatc gagtgcgggt tcgcggtgtt ggtgcagctg
     1501 gtgatcgccg cgatggcgac ggcgccgtcc gcgagctcgc gccggccctc ggcggccccg
     1561 gcgagcgcgg ccccggacgg ctcggggaag ctggccggga cggtgccgag cggcagccgg
     1621 tcctgcggcc gccgcggccc ggccgcgctc ggctccacgg cggacaggtc gaagtcgagc
     1681 acccgggcga actccgggtc ggccgacgcg tcggcgcccg cgaacaggcc ctgctccttg
     1741 cagtacgcct cgaccagccg gatctcctcg gcgccgcgcc cggtcagttc gaggtagcgc
     1801 agggtggtgt cgtcgaccgg gaagaaggcc accgtgcagc cgtactcggg cgccatgttg
     1861 gacagggtgg cccggtcggg gacggagagc gcgcagacgc ccggcccgaa gaactcgacg
     1921 aaccggccga ccacgccgac gttgcgcagg aactcggtca tggtgagcgc gaggtcggtc
     1981 gcggtgctgc cgaccgggag ctcgccggtc agccggaccc cgatcacctg cgggctgagc
     2041 agcgagaccg agtggcccag cagcacggtc tcggcctcga tgccgccgac gccccagccg
     2101 agcacgccga gtgcgccgac catcggcgtg tgggagtcgg tgccgaggac ggtgtccggg
     2161 gcgatcagcc cgtcgccgtc cggcagcacg acccgggcca ggtgctccag gtgcatctgg
     2221 tgcacgatgc cccgcccggg cggcaccacc cgcaggccgc tgatctcctg ctgggcccag
     2281 cgcaggaacc ggtagcgctc gccgttgagt tcgtactcac ggcgcatgtt cagcgagagc
     2341 gcgtcgggcc gcgcccagct ggccacctcc accgagtggt ccaccaccag gtcgaccggg
     2401 agcgcgggcc gggccagccg cggatcgaga ccgcggtccg ccatgatgga ccgcagcgag
     2461 gccagatccg ccagcaccgg aattcccgaa tggtcctgca ggacgagtcg ggtgggccgg
     2521 aattcgacct cgctgaccgg gccgttcgcg gtggccgccg ctatcaggga gttcgccgac
     2581 agaacggcct gacgaagcga atccccggta ctcccggcct ttgctgcggc cgccgcccgt
     2641 agggtattct ccaccagcac ccggaggctg cgcggtgcgc tggatatgcc gaccagcccc
     2701 atttcttccg cggccgccag actgacgtag cgggcgttcc ggtcgggcag ccgcaggtcc
     2761 cgtaacaggt cgcgcatgtc tgagtctctt tttctcttcg gatcttcaac gaaatcgagg
     2821 gtgagatgac tgtttcccag tacccggacg tcgccgtccg gagcgactcg ccgcgcccgg
     2881 aggccagcgt gctgccggcc gccctggagc tgctggagtc ggccggcctg accgcgaact
     2941 ggcggatcgt cgccggtcag gcgccggacg gggacggagg gcggaagccg gaggcaggcc
     3001 tgctgccgcc cttcgccgag ccgggggcgt cggcgtacgg tctggcccgc gccgcccggc
     3061 gcgcctgggg cgggacgttc agcgtgatcg agcgccgcgg ccccctggtg cgttccgatg
     3121 gcaccgtgaa cgtcctcctg ttccgctacg agctcgacat gagcgatacc gggatggaat
     3181 tcgagagcaa ttccggggaa cagctcgcgc tggtcaagac ggctgccgaa ctcgggcccc
     3241 gggagatacc ggagcaggcc gccctgggaa ttcaggcgat cgctccggac cgggtttccg
     3301 agttcgtccg gacggcggtc ggaatgtgcc gccgactgga tgtcgacgac ctcgtggtgg
     3361 cgcacaaggg gaattcgatc aaacacaccg acgggctttt cgcactgacc gcggccgaga
     3421 ccctggagag cctcgccggt gcggccggga tcgcctggcg gagcctgatc atcgatcaca
     3481 tggccgccga gttggtccgg aacccgctcg actaccgggc gatcctcacg cacagctcgt
     3541 tcgccgatct gctcgccgcc gcgctggccg gccagatgac caccgaccag ctcggcgtct
     3601 gcaccaccta cgacccggcc ggccggccgc tgttcggcca cgaccccgcc ctggacacca
     3661 gtgccccgga cgcggacccc gaacggtggc gggtccgccg gctcgcctcg acgctggcgg
     3721 caggcgcggc gctcgccgag cacctgcgcc tgccgccggc cggccgcgcc ctgcgccgag
     3781 cggcggccga actcgtgcgc cgggacggcg gcccgatcgg ttgggaccag gcggtgacca
     3841 cggcccggaa gtcgctccgg gccgagggcc ccgcccggtc ctgaccggtc gtcaacaagg
     3901 tcaggcggcg gccttgttgt agatctcgac gagctgctcg tgcgagacgg cgccgccgat
     3961 cctgatcgac agggcccgga cctcctccag gcagtgcggc agcagctcct cgcgcggggt
     4021 gatgccctcc tgctccagcg cccaggcgac cagcgcccgg ccggagtgct tgccgagcac
     4081 gtaccggcgc tcgccgccga cgtgctccgg cgggaagggc tcgaaggagg aggtgtcgcg
     4141 gaacatgccg ttggcgtgga tgcccgactc gtgcgcgaac acgttgtcgc cggtgatcgg
     4201 ctgccagggg aggacctggt ggccggccgc ctccgccacc agccggctga ccttcttcag
     4261 cttggtcagg tcgatgccca ggtcgcggtc gtacagcttc ttcagggcga ccacgacctg
     4321 cgcgaggtcg gccatgccgg cccgctcgcc gatggcgttc acggtgacgt ggaagtaccg
     4381 cgccccggcc ttgaggccgg ccagcgtgtt ggcggtggcc aggccgaagt cgttgtgcgc
     4441 gtggcactgc acgtcgatgt cggccgcgct cagcaccgcg gccacccgct cgccgtaggc
     4501 ctccgggccg agcaggccca cggtgtcgga gagccggagg cggtccgcgc cggcctcggc
     4561 gaccaccccg gcatactcct gcaggaagga gatctcggtc cgggcgatgt cctcggcgct
     4621 gatcgagacg aacgcgcccc ggtccttggc catcttgacc atgtcgcggg ccgtcgcgag
     4681 gagccaggtg cggtccttgc gcacgctggc cttgaggtgg ccggccgagg tcggcaggcc
     4741 gacgtggacg gacgtgaagc ccaggtcgag ggagcgttcg acgtcctcgc ggacaccacg
     4801 gtgccacacc accaggcggg cttcgtcctg ccggtcgacg acggacttga tgaagtccag
     4861 ttcctcgccg cccatggcgg ggatgccgat ctcgatcgac gtcaccccgg cctcgatgag
     4921 cgcgttgagg atcgccgtct tcgtttcctt cgagaacgcc acgcccgggg tctgttcccc
     4981 gtcgcgcaga gtggtgtcct cgagcactaa gtcgttgcgc atcttgcgga atcctccttg
     5041 agggacaact tggataccgg tgccgatagc aaggcaagat cagcggaatc ggacataacg
     5101 ggccgcggat gatacagggc cggactccgg ccgccttcga atctccttgc caacccctgt
     5161 gacgggtggt tagctagcat agctcgtgtg gtcggtggcg tacatggggt tgactgtccc
     5221 ccgacaccag gtgaacggtt agcgcatcat ccatcttcgg actgggagat tccttgacca
     5281 agcgaaccat gttacgcagg gccatcgcac gcggcggaat gtcgatcgcc gccggtgtgc
     5341 acgacggtct gagcgcgcga atagcccagg acgcgggatt cgatgttctg tgggcgagcg
     5401 gtctgggaat ttccgccgca cacgccgtcc cggacgacag catcctgacg atgacggaat
     5461 tcctggaagc ggccagggtc atgaacgaca gcaccgacct cccggtgctg gccgactgcg
     5521 acaccgggtt cggcgacgaa cgcaacgtgg cccggatggt cgagcggtac gagcgggccg
     5581 gcatcgccgg cgtctgcatc gaggacaagg tcttcccgaa gcgcaactcg ctcggtgacg
     5641 gggcccagga ccaggagacg atcgagggct tcgccgccaa gctcgcggcg gccaagaagg
     5701 cccagcagac cgacgacttc gtggtcgtgg cgcggatcga gaccttcatc gccggcggcg
     5761 tcaaggagga cgcgatcgcg cgggccgacg cctacgtcgc ggccggcgcg gacgccatcc
     5821 tgatccactc caagtcgcgg gacggcctgg agatcctgga cttcggccgc agctggcagc
     5881 gcaaggacgt gccgctggtc gccgtcccga ccacgtaccc cgcggtgacc gcggacgacc
     5941 tccacgaggc cggcttctcg ctcgcgatct acgccaacca ggcgctgcgg gcctccatca
     6001 cctcgatgcg cgagagcctg cgtcagatca cgcacgaccg ctccagcctg cggatcgagc
     6061 cgaaggtcgc gaagctctcc gaggtcttcg agctccagcg ctgagccgcc gccgcccacc
     6121 cacggcgtcg agaggtgcgg cgccgtccac ccacggcgtc gagcggtgtg gcgccgcaga
     6181 cacgagaagc catgcgtaaa cacacagtca ctctgatcgc gggagacggc agcggcccgg
     6241 agctggtcgc cgccgcccgg acggtactgg acaccgcggc gggctccgcg ggcttccacc
     6301 tcgactggga cgtccggccg gccggccagg gcgcgctccg gtcggtgggg gagctgctgc
     6361 ccgcgagcac gctcgattcg atccggcgca acggggtggc cctgaagggg ccgaccacga
     6421 cgccgatcgg ggtgggccac cggtcggtga acatcacgat ccgccgggag ctcgacctgt
     6481 acgcgtgcgt ccggccggtg cgggtctggc cgggcgccgg ggcggtcgat tccggcatcg
     6541 acgtcgtggt cgtccgggag aacaccgagg acgtctattc cgggctggag tacccggcgg
     6601 attcggacgg ggcggcggtg gtttcggcca ccctgtcgga attcggtcac gccgacccgg
     6661 gaatcgcctt ctcgctgaag ccgatcactc cgggcggaag ccgccggatc gtcgccttcg
     6721 cgctcgacca cgcccggaag aacggccgga gaaaggtcga ggtgggtgcc gacgtctatc
     6781 gttacccgag aaccgagggg cttttcttcg aggcggcccg ggaactcggc ccggagtatc
     6841 cggacatcgt cacggcgacc gttccggtca ccgttctctg cgattccctg gtccgcgatc
     6901 cggcggaccg cgacgtcctc gtcctgccca atctgtacgg cgacgtgatc tccgacgtca
     6961 ccgccgcact ggtcggcgga ctggggatgg caccgggcgc caatatcggt gaccggacgg
     7021 ccgtgttcga agcgacccac ggttccgccc cggaattcgc cggaagcaat cggctcaatc
     7081 ccacggccct gatcctgtcc ggctgcatgc tgctggacca cctcggcgag gcaccgacgg
     7141 cggcccggat ccgggccgcc gtgcggagcg tgctcgagga gggccggtcc gtcaccttcg
     7201 acctgctgcc gcccgaccgg gcggcgcggg ccgtgaccac cacggcctac gccgaagccg
     7261 tcatcgagcg cctgcgggac atcggatgat ccgtcacatc gacgcgagga gggaagactt
     7321 ggagccggac cgtcaggacc gggagctcgt caccagggac cggctggcgt cggacctggc
     7381 cgcactgggg gtgcgccccg gcggcgtact gctggtccac gcgtcgctgt ccgcactcgg
     7441 gtgggtgtgc ggaggggccc aggccgtcgt gctcgccctg caggacgccg tcggcaagga
     7501 gggcacgctg gtcatgccga cgttctccgg cgacctgtcg gacccgtcca cctggcgccg
     7561 tcccccggtg ccggaggact ggtggccggt catccgggag cagatgccgc ccttcgaccc
     7621 cgacctgacg cccacccggg gcatgggggc ggtcgccgag tgcttccgcc gcgcggccgg
     7681 cgcggtgcgc agcggccacc cgcagaactc cttcgccgcc tggggcgcgc acgccgaaca
     7741 ggtcgtcgcc gagcacggcc tgacggagcg cctggggagg ggatcgccgc tggagcaggt
     7801 ctaccggctc gacggccagg tgctgctcct gggctgcggc ttcgagagca acacctcctt
     7861 ccacctcgcc gagtaccgca ccgcgtaccc cggccggcgg agccaccgca ggcgggtccc
     7921 ggtgccggag ggcgaccggg tgcgctgggt cgagcaggag gacatcgtct acttcgagga
     7981 ggacttccaa accatggggg agagctgcct cacccgtact ccgggacact cccgggggac
     8041 ggtcggcgag gccgctgccg tgctctacgg ccagcgcgcc ttcgtcgacc tggcctgcga
     8101 gtggatgacg gcgcaccggg acctcgcccg ggcggtgggc gcatgacgca ctacgcgacc
     8161 gtcatctgcg gcggtggccc cgcgggcgtc tccgcggtgg tggccgccgc ggtccagggg
     8221 cggctggagg agttcctcga ccggggcgtc ctgctggtcg aggccaccgg gcgagcggga
     8281 tcgggctcca tcccgcacta cgggatccgc gccaactcgc tgggctcggc cttcctggag
     8341 tgcctggacg gccccgccgg gagcggcctg ctggccgggc tggcggacag cgccgaggcc
     8401 cgggagctca ggggctgggc cgacgagtac ccgccgctgc cggtggtcgg cgccttcctg
     8461 accctggtcg gcgagcgggt cgtcgacgcc ctgcgccgac acccgcgctg cgacgccctt
     8521 ttggggcacc gggtggtcga ggtcaggacc gggccggagc gcgcgacggt gctgctctcc
     8581 gggccggacg gcgagctctc gcacaccggc gaccgggtcc tgctgaccat gggcgggcgc
     8641 gagcggaccg agctggcccc ggacgcgctg gcggccctcg tggagcgccg gcccgggctg
     8701 cgggtgctgt cctccggcga ggtcatcacc gacccgtcct ggcaccccga cgccgcatcc
     8761 ccgcaccgcg cgctcggcag catcgccgtc ctcggcggcg cccacagcgc ctgggcggtc
     8821 gccgcccacc tggcccggct ggcccgcgcg ggctggttcg ccgggccggt ggaggtcacg
     8881 gtggtcgagc gccggctgcc gccgatcttc tacttctcgg cggccgaggc ccgggccgag
     8941 ggctaccgct gggacgaggc cgacgtctgc gggcccagcg gccgggtgca ccggttcggc
     9001 gggctccgcg ggccggcccg ggaactggcg cggcaggtca tgggcctggc cgcggagaag
     9061 gcgccggacg gcttcggcca ggtcgtcctg gacggcccct ggacggcgga ggcgctggag
     9121 gccgccgtcg gcgacgcgga cctggtcatc accgcgctcg gctacgacgc gcggctgccc
     9181 cggctgctcg gcgcggacgg ccgggagctc gaactggccc gcccccgtgg cgcggtggac
     9241 accggccggg acggcctgcc cggcctggcc gcgggcggcc gcgccgaacg gctggtgatg
     9301 tacggactgg gcgccgggct cgtcccgtcg gaggagaccg gcggcgagcc ggggtaccgg
     9361 gggcgcctcg acggcgtctg ggtgtaccag cacgacatcg gcgccgtgat cctccgcgcc
     9421 ctgctcgcca acgatcgtac ggaggatggg cgttgaacga gaaccggacc ttcgccacgc
     9481 cggacgcggt gccggtcagg gccgtcgtgc tggcggcggg actcgggtcg cggctggggg
     9541 agccctcctc ccggcggccc aagccgctca ccccggtggc cggccgcccg atcctggccc
     9601 acaccctcgg ccacctggcc ggcgtcggcg tccaggaggt ggtcctcgtc gtgggccacc
     9661 tgcgggaggc cgtacgggag ctcgcgggcg gcgagtacgc cggaatgaag atccattacg
     9721 tggtcaaccc ggacccctcg acgaccaaca acctccgatc ggtccggctg gcccgcgagt
     9781 tcctcgacca ggacgtcttc ctgctggagg gcgacgtggt gttcgagccg gccgtgctgg
     9841 agcggctggc ggccgccccg gaggccagcg cggtggcggc gagccgaccg ctgcggccgc
     9901 tcgccggcac cgtggtccgg gccgacgcgg acggcgtgct caccgactac gtcgacgacc
     9961 gccggcaggc cggggcgttc gaccaccccg gcgcgctcaa gacggccaac ctctacctgc
    10021 tgcgcgaggc cttcctgcgg gagcggttcc tgcccgccct ggaggagctc gaccggcggt
    10081 tggccggcca gggctactac gactacgccg tcagcgacgg cctggccgcc gggggccacg
    10141 cctggcgggt cgccgacatc agcgacctcg cctggtacga ggtggacgac ccgggcgacc
    10201 agcgccaggc cgacttccgg ttcagcccgc cgcgcgagca gcagcggatc ctggagtcgc
    10261 tgcacggcgg ctactggcgc tacggggtga cggaccacgc cctgctctac aacgtgcact
    10321 tcccgcccgc cgagatgatg gagatcctgc gctcggactt cgacgcggtg ctgcgcaact
    10381 acccctcggc ccacgcgccg ctcaccgagc tggccgcgac catcgccgcc cggcggccgg
    10441 aggaggtcgt gctggccaac gggagctcgg agatcatcaa gatcctggcc cgcctgcgcg
    10501 ggaactggac cgtcccggtc cccggcttca acgagtacga gaacgtcgtc ggcgccgaac
    10561 gggtgcaccg gtaccagctc gacgcgcccg acttccggct cccggtggag gactacgccg
    10621 ccttcgtccg gcgcagcggg gtcgacacgg cggtcgtggt gagccccaac aacccgacct
    10681 cggtcggcgt cccgctggcc gatctgcgcc ggctcgccga cctggtgggc cccgacgtgc
    10741 tgctggtgat cgacgagtcc ttcgtcgact tcgcgcccgc gccgatcgcc tcgatcggcc
    10801 cgttcctgga ccggcaccgc aacgtgctgc tgctcaagag catcagcaag gtctacggcg
    10861 tcggcgggat ccggctgggg tacgcggcca ccgcggacac cgagctcgcc cggaccctgc
    10921 gggcggagct gccgatctgg gacatcaacg ggttcgcgga ggagttcctg cgggtgctgc
    10981 cgcacttccg ccgggccttc gcggacagct gccggcagat gcggcagaac acgctcgcgc
    11041 tggccgaggg gctggcggcg ctccccggga tccgggtggt gccgccggac gcgaacttcg
    11101 tcttcgtcga gctcaccggc gggatccggg cgcccgagct ggcccacgag ctgttccgcc
    11161 ggttccggat cctcaccaag gagtgctccg ggaagtccat gccgggcggg gacgcctacc
    11221 tgcgggtctc cagccgcagc cgcgcggaga acgaggtggt ggtcgccgcg gtcgccgaga
    11281 tcgtcggcgg cccgcggggc gccgcgacga ccgagggggc gggccgtgcc gacggctgag
    11341 gacggcgcgc aggtgcgctg gctggggcgg ggcgagcggg tcgtccacga cagccgcttc
    11401 ctgaccgtgt cggtggccga cgtcgagctg ccgggcggcg agacggtcga gcaccacttc
    11461 gtccgggcgc cgggcgcggc gatcatcgtc gtgcaggacg agcggcagcg gatcctgatg
    11521 atgtaccggc accgcttcgt ctccgacctg tggggctggg agctgcccgg cggcctggtc
    11581 gacgaccggg aggatccggc ggtgacggcc gcccgcgagg cggaggagga gaccggctac
    11641 cgccccagga acgtccgcca cctcctcacc taccagccga tggcgggcat ggtcgacagc
    11701 ccgcaccaca tctacctggc ggacggcgcg gacctggtcg gcgggccgac cgagtgcacc
    11761 gaggcgcagg agacgcggtg gatgccgctc gacgaggctg ccgaactcct gcgctccgga
    11821 cgcaccgtga cgtccggtac ggccatcggc cttctggcgg tgctggggct cggcggggcg
    11881 cggcagcagc ccggcggggt gcaggagcag cccggcgggg cgcagcagca gggaatgaac
    11941 gaatcgcact caggaaggac agttcgtggt tgagattctg aagaagcccg tcaccggccg
    12001 cagcgtctgg cagcgtgcgc aggtcgagga cgcctcgcag tggacctacg tcctcgacga
    12061 ggggatgcgg gccgagatcc tggaggccgc cgagcggatc aacgagcagg gcctgacggt
    12121 ctgggacctc gaccgcaagg ccgtcccgct ggagcgggcc gggaagctcg tggcgcagtg
    12181 cgtcgagcag ttggagcacg gcttcggcct ggccatgctc aggggcgtgc ccaccgaggg
    12241 cctgaccgtg gccgagtcgc aggtggtgat gggcgtcgtc ggcctgcacc tgggcaccgc
    12301 ggtggcccag aacgggcacg gcgaccgggt cgtgtcgatc cgcgactacg gcaagggccg
    12361 gctgaactcc aagaccatcc gcggctacca gaccaacgag tcgctgccct ggcacagcga
    12421 cgccccggac atcgccgcgc tgctgtgcct gacgcaggcc aagcacggcg gcgagttcca
    12481 cgtggcgagc gccatgcaca tctacaacac cctgctgcag gaggcccccg aactgctcgg
    12541 gctgtactac gccggggtgt tcttcgacta ccgcggcgag gagccgcccg gtgagccgcc
    12601 ggcctaccgc aacgccatct tcggctacca caacggccag ttgagctgcc gctacttcct
    12661 gcgcaacttc gccgactccg gcacggcgaa gctcggcttc gagcagccgg aggtggagaa
    12721 gctcgccctc gacaccttcg aggagatcgc ctcccggccg gagaaccacg tctcgatgcg
    12781 cctggagccc ggcgacatgc agctcgtgga cgacaacgtc accgtgcacc ggcgcggcgc
    12841 gtacagcgac gaggaggacg gcagcaccga cagctcccgc cacctcctgc ggctgtggat
    12901 caacgtggag aacggccggc agttccccac ctcgctgtcc acccaccgct ggggcatgaa
    12961 ggcggcggcg aagccgacgc actgacggaa gtccgcgcga ggccggcccg gggcgccccg
    13021 ggccggcctc gcggtgctgc tcgcggtcgt gtgcggaagg tgccgatcac ccgggagagt
    13081 cggccgggtg acgggccgtc acgggattcg cgatacgctg acgatcgtga cttctctctc
    13141 gaacgaccct cgcagcgtcg tcatcctggg ctcgacgggg tccatcggaa cgcaggccat
    13201 cgacgtcatc cagcgcaacc gcgcgcggtt ccgggtgcgg gcgctctcgg ccggcggcgg
    13261 caacctgtcc ctgctggccg cccaggcgct cgacctcgag gtcgagcagg tgggtctggc
    13321 ggacagcggc gccgtcgagg acttccgggc cgccctgcgc gacgaggccg ccaagcgcgg
    13381 cctgaagtcg ggcgacttca agctgccgga cctgctccac ggcccggagg cctcgaccga
    13441 gctcgcggcc ctgccgtgcg actcggtgct gaacggcatc accggctcgg tcggcctgga
    13501 gccgaccctc gcggcgctga agtcgggcag caggctcatc ctggcgaaca aggagtcgct
    13561 gatcgtcggc gggccgctgg tcaagaaggt ggccgcgccc ggtcagatcc tcccggtcga
    13621 ctccgagcac tccgcgctgt tccagtgcct ccagggcggc aaggagcagg acgtccgcaa
    13681 gctggtggtc accgcgagcg gcggcccgtt ccacggccgc ggccgggccg agatggccgc
    13741 cgtcacgccg gagcaggccc tggcccaccc ggtgtggaac atggggccgg tcatcaccat
    13801 caactgcgcg aacctggtga acaagggcct ggaggtgatc gaggcgcacc tgctcttcga
    13861 catcccgttc agccgcatcg aggtcgtggt ccacccgcag gtgatggtcc actcgatggt
    13921 cgagttcacg gacgggtcca ccctggcgca ggtgagtccg ccggacatcc ggctgccgct
    13981 gtccctcggg ctcggctggc cggaccgggt gccggacgcg gcgccctcct gcgactggac
    14041 caaggcgtcg acctgggagt tcttcccggt ggacggcgac gcgttcccgg gcgtccagct
    14101 cgcctacgag gtcggcgagg ccggcggcac cgtgcccgcc gtgttcaacg ccgccaacga
    14161 ggagctggtg gcggccttcg tcgcgggccg gctgcccttc ctcggcatcg tggacacgct
    14221 cggcaagatc gtcggggagc acgaccgggt gccgaacgag gcgatgacgc tggaggcgat
    14281 cgccgaggcg gaccgctggg cgcgggcccg ggcgaaggag ctcgtcggcc tgtccgactg
    14341 acgcgagtga gtcatgtgaa caagtgacgc gcgctgaagc ggtgtcaccc gtccccgggt
    14401 ctccggggcg tgggtggcac cgcttccgtg tgtcgcggcg cgggcccggg gcgggccggt
    14461 cgcgtcactc gcccggcagg tgaccggggc gcccggagcc gatggtgtcg gcgagggcgc
    14521 ggaagacgag cgtggtcgag gcggcgcccg ggtcctggtg cccgatggtg cgcaacccca
    14581 ggtaggaggc ccggcccttc cgggcccgca gcgtgatggt ggtgtccagg gcggtctccg
    14641 cggcctcggc ggcggccctg gcggccgcga ggaagccccc gtgggcgagg acggtgtccc
    14701 ggaacgcggc gacggccggg gcgtaggcgt cgaccatggt cttgtccccg ggatccgcgg
    14761 cccccagttc ctggagcacg tcgagcccgg cctggagcgc ctcggcgaag cgggcctcgt
    14821 cggtctcggc ggtgtcgccg agcgccgtgc ccatggcccg gaacgcgctg ccgtagaggg
    14881 ggccggcggc gcctccgacg gtggagatca gcaccccgcc ggtgaagtcc agcaggccgc
    14941 cgacggtttc gtccgagcgg ggtgccgctc cgagttcgag ggcggcccgg gtgaagccgc
    15001 ggaccaggtt gactccgtgg tccccgtctc cgatgactga atcgagttcc gtcagacggt
    15061 cacggtgttc ttcgag
//
