LOCUS       BGC0000908              6497 bp    DNA     linear   BCT 11-OCT-2001
DEFINITION  Streptomyces avermitilis melanin biosynthetic gene cluster.
ACCESSION   BGC0000908
VERSION     BGC0000908
KEYWORDS    .
SOURCE      Streptomyces avermitilis
  ORGANISM  Streptomyces avermitilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 14:24:42
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6497
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..492)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAB69173.1"
                     /transl_table=11
                     /translation="MKPLTGSTTDQAPADPAATDDVLATQPIGYWSGLAHTAVTRQLRD
                     AMARIDVTQPQYWVLNRVHGGPAAPGREEVVTQLTPLADGPHEIARVVDQLLHRGWLRI
                     DAGQRLRLTDTGEAARKRLRELVTELRAVVHEGISDEEYVTALKVLRTMIANVEGDAGC
                     "
     source          1..6497
                     /db_xref="taxon:33903"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces avermitilis"
     subregion       1..6497
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6497
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             701..1411
                     /codon_start=1
                     /product="ribonuclease H"
                     /protein_id="BAB69174.1"
                     /transl_table=11
                     /translation="MIGGMSERVVAACDGASKGNPGPAGWAWVVADGEETPTRWAAGAL
                     GTATNNVAELTALERLLSAMDPDVPLEIRMDSQYAMKAVTTWLPGWKRKGWKTAAGKPV
                     ANQELVARIDELLDGRSVEFRYVPAHQVDGDRLNDFADRAASQAAIVQEPAGSEYGSPE
                     PPKSPDTVAAGSAGRGAPAKKRASARTAKTSTRTIKAKFPGRCVCGRPYAAGEPIAKNA
                     QGWGHPECRTADDV"
     gene            complement(1553..2377)
                     /gene="melC2"
     CDS             complement(1553..2377)
                     /codon_start=1
                     /gene="melC2"
                     /product="tyrosinase"
                     /protein_id="BAB69175.1"
                     /transl_table=11
                     /translation="MTVRKNQATLTADEKRRFVDALVALKRSGRYDEFVTTHNAFIMGD
                     TDSGERTGHRSPSFLPWHRRFLIEFEQALQAVDPSVALPYWDWSTDRTARASLWAPDFL
                     GGSGRSLDGRVMDGPFAASTGNWPVNVRVDSRTYLRRTLGGGGRELPTRAEVDSVLAMS
                     TYDMAPWNSASDGFRNHLEGWRGVNLHNRVHVWVGGQMATGVSPNDPVFWLHHAYIDRL
                     WAQWQSRHPGSGYVPTGGTPNVVDLNETMKPWNDVRPADLLDHTAHYTFDTV"
     gene            complement(2413..2769)
                     /gene="melC1"
     CDS             complement(2413..2769)
                     /codon_start=1
                     /gene="melC1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /product="tyrosinase co-factor protein"
                     /protein_id="BAB69176.1"
                     /sec_met_domain="melC (E-value: 1.5e-50, bitscore: 160.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELTRRHALGAAAALAAVAGTQALAAPSASAAGHHGGPQPFDEV
                     YQGRRIEGRATGGGHHHGSGYGVFIDGMELHVMQNVDGSWISVVSHYDPVATPRAAARA
                     AVVELQGAPLVPFN"
     CDS             complement(3051..3518)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAB69177.1"
                     /transl_table=11
                     /translation="MTHPPAGPVLAALVSRATGGRYWRLDRPGAGLDAEAMHIPPGAAA
                     EPPGDRSRDVLVIALDGGGRLRTPGGWLELAPPAAVWLPPAAGYRLHAGEAGLHCVTVR
                     PRRPAAPPALPTTGATGEPACLLHQVCAECGRMATESDARYCNRCGNPLER"
     CDS             3672..4877
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 110.3; E-value: 2.2e-33)"
                     /gene_kind="other"
                     /product="putative hydroxylase"
                     /protein_id="BAB69178.1"
                     /transl_table=11
                     /translation="MKIACVGGGPASLYFSILMKRQDPSHDITVHERNPAGSTYGWGVT
                     YWSGLLDKLRGSDPESALAVSENSVRWSDGVAHVRNRTTVHHGDEGFGIGRRRFLDVLA
                     DRARSLGVRIEYEHEIGADDPLPEADLVVAGDGVNSVLRGRYADHFGSETVLGRNRYIW
                     LGTTKVFDSFTFAFVESEHGWIWCYGYGFSDGHSTCVIECSPETWTGLGLDRASEADGL
                     ALLEKLFADVLDGHELIGRAQSDGAAQWLNFRTLTNRTWHRDNLVLIGDAAHTTHYSIG
                     AGTTLALEDAIALAEALSAHRDLPGALAAYERERKSALLHIQSAARLSAQWYENLPRYI
                     RLPPPQMFALLGQRHSPLLPYVPPQLYYRIDRAAGQLEALRRLKRWLGPRLARTVQART
                     GR"
     CDS             4941..6497
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 289.9; E-value:
                     4.3e-88)"
                     /gene_kind="transport"
                     /product="membrane transport protein"
                     /protein_id="BAB69179.1"
                     /transl_table=11
                     /translation="MNSYSPPFFTSAAAPGVTMVPISTPSDRSATPDGPAGRPGVRDRL
                     TVPVLAFGGILMAVMQTVVVPLLPDLPRLTGASAGAVSWMVTATLLSGAVLTPVLGRAG
                     DMYGKRRVLLAALALMTLGSLLCAVTSDIRVLIAARALQGAAAAVVPLSISILRDELPP
                     ERTGSAVALMSSTVGIGAALGLPIAAMIVQYADWHVMFWATTGLGAGGLALAWWAVRES
                     PVRQPGRFDTLGALGLAAGLVCLLLGVSQGGQWGWTSPRIVGLLVACVLVLTLWWFQQW
                     RAPRPLVDLKLASRPRVALPHVAALLTGFAFYGNSLVTAQLVQAPKATGYGLGLSIVQT
                     GLCLLPGGVIMLLFSPVSARISAARGPRVTLALGAAVIAVGYAVRIADSRDLWMIIVGA
                     TVIAVGTTLAYSALPTLILRAVPAGQTASANGVNVLMRTIGQAVCSAAVAAVLVHHTSL
                     VGGAPVPTLHGYLLAFAMAGTVAVMACAAALVIPGDPDSHGTRRARGRTRPSHDEALEG
                     A"
ORIGIN
        1 ctagcagccc gcatcgccct cgacgttggc gatcatcgtg cgcagcacct tgagcgcggt
       61 cacgtactcc tcgtcgctga tgccctcgtg gaccaccgcg cgcagctcgg tcaccagctc
      121 acgcagccgc ttcctggcag cctccccggt gtcggtgaga cgcaggcgct gtccggcgtc
      181 gatccgaagc cagccccggt gaagcagctg gtcgacgacc cgcgcgatct cgtgcggccc
      241 gtccgcgagg ggcgtcagct gggtgaccac ctcctcccgg cccggcgccg cgggcccgcc
      301 gtgcacgcgg ttgagcaccc agtactgcgg ctgtgtgacg tcgatcctgg ccatggcgtc
      361 ccgcagctgc cgggtgaccg ccgtgtgggc cagaccgctc cagtagccga tgggctgggt
      421 ggccaacacg tcgtcggtgg cggccggatc ggccggtgcc tggtcggtgg tgctgccggt
      481 caacggtttc atgatcgtga cgctaggtcc ccgtagcgtg cgtgaacacc gtcgaaccag
      541 gcaaggtctg gccgaaacct ccgcccctcc aggtggacca ccccgtgcgg cgcgaccttc
      601 gtccacgtcc cgacgcacgg tgatcgtgct gggggccagc ccctcctgga gggcgtcggc
      661 ggcgtcggac ccgggcccgg agcgcccggc ggagcgtggc atgatcgggg gcatgtctga
      721 acgtgtggtg gccgcctgtg acggggcgtc gaagggaaac cccggaccgg ccggatgggc
      781 ctgggtcgtc gccgacggcg aggagacccc gacccgctgg gcggccgggg cgctcggcac
      841 ggccacgaac aacgtggccg aactcaccgc gctggagcgc ttgttgagcg cgatggatcc
      901 ggacgtcccg ctggagatcc ggatggactc ccagtacgcg atgaaggccg tcacgacctg
      961 gctgcccggc tggaagcgca agggctggaa gacggccgcg gggaagccgg tcgccaacca
     1021 ggaactggtc gcccgcatcg acgaactgct cgacggacgc tccgtcgagt tccgttacgt
     1081 ccccgcgcac caggtcgacg gcgaccggct caacgacttc gccgaccgtg ccgccagcca
     1141 ggcggcgatc gtccaggaac cggcgggcag cgagtacggc tccccggagc cgccgaagtc
     1201 gcccgacacc gtcgcggccg gctccgcggg tcgcggcgct cccgccaaga agcgtgcctc
     1261 cgcgcgcacc gccaagacga gcacgcgcac gatcaaggcg aagttccccg gccgctgtgt
     1321 ctgcggccgc ccctacgcgg cgggcgagcc catcgccaag aacgcgcagg gctggggcca
     1381 cccggagtgc cgtaccgccg acgacgtcta ggacctcccc ggcggagcat gcccaaggac
     1441 gcgggggctg acaggccgtg cggcttttcc cgcccgcctg atccgccggc cctggatcac
     1501 gaccccggcg gcctcccacg agtggccgcc gggacctcga gcgcctcggc cgtcagacgg
     1561 tgtcgaacgt gtagtgcgcg gtgtggtcca gcaggtccgc ggggcgtacg tcgttccacg
     1621 gcttcatggt ctcgttcagg tcgacgacgt tcggcgtgcc gcccgtcggc acataaccgg
     1681 agcccgggtg gcggctctgc cactgggccc agagcctgtc gatgtaggcg tggtggagcc
     1741 agaagaccgg gtcgttgggg gagaccccgg tggccatctg gccgccgacc cagacgtgga
     1801 cgcggttgtg caggttcaca ccgcgccagc cctcgagatg gttgcggaac ccgtccgacg
     1861 cgctgttcca cggggccatg tcgtacgtgg acatcgcgag cacggagtcg acctccgccc
     1921 gggtcggcag ctcgcgcccg ccgccgccga gcgtgcgccg cagatacgta cggctgtcga
     1981 cccgcacgtt gaccggccag ttgccggtgg acgccgcgaa cggcccgtcc atcacccggc
     2041 cgtccaggct gcgtccgctg ccgccgagga agtcgggcgc ccacagggag gcacgcgccg
     2101 tgcggtcggt gctccagtcc cagtacggca gcgcgaccga cgggtcgacc gcctggagcg
     2161 cctgctcgaa ctcgatcaaa aatctgcggt gccagggcag gaaggaaggc gaacgatggc
     2221 ccgtgcgttc gccgctgtcg gtgtcgccca tgatgaaggc gttgtgggtc gtgacgaact
     2281 cgtcgtagcg gccactgcgc ttgagcgcca cgagcgcgtc gacgaagcgc cgcttctcgt
     2341 cggccgtcag ggtcgcctgg ttcttgcgta cggtcatgtg cgggtgactc cagaactcta
     2401 cgtgcgggac ggtcagttga aggggacgag cggcgcgccc tgaagctcca cgaccgcggc
     2461 gcgggcggcg gcgcgcgggg tggccacggg gtcgtagtgg ctgacgacgc tgatccagct
     2521 gccgtcgacg ttctgcatca cgtgcagttc catcccgtcg atgaacacgc cgtacccgga
     2581 gccgtggtga tgaccgcccc cggtcgcgcg gccctctatt cggcgcccct gatagacctc
     2641 gtcgaacggc tggggacccc cgtggtgccc ggccgcggac gcggacggag cggcaagggc
     2701 ctgagtgccg gccacggccg ccagggcggc ggcggccccg agggcatgac ggcgggtgag
     2761 ttcgggcatg cgaagtcctt ctgagtcgag gtgtgttgac gactcggcat gcctatccgc
     2821 ccggtcggga gccggagaaa tcgacgaaaa ccggttggct acgatccgga caattaccta
     2881 catgtcatac aggattgaac gaagatgatc ttgccgcccc gggtggccca cccggcggcg
     2941 gagggggaag ttccaccccg gatcggcgcc atcgcggtga tcttttgccg tcgatgcggg
     3001 gcgagtggtg cggctcacgt gcgcagactg gcgcgaactg gcgcctgccc tcaccgctcc
     3061 agggggttcc cgcagcgatt gcagtagcgg gcgtcgctct ccgtggccat acgtccgcac
     3121 tcggcgcaga cctggtgcag caggcatgcg ggctctccgg tcgcccccgt cgtcggcagg
     3181 gccgggggag cggccggacg gcgcgggcgt acggtcacgc agtgcagccc cgcctccccc
     3241 gcgtgcagcc ggtatccagc ggcggggggc agccacacgg cggccggggg tgccaactcc
     3301 agccatccgc ccggtgtccg gagccggccg cccccgtcga gggcgatcac gaggacgtcc
     3361 cgcgagcggt caccgggcgg ctcggccgcc gcacccggcg ggatgtgcat cgcctcggcg
     3421 tcgagaccgg cgcccggccg gtccagtcgc cagtagcggc ccccggtcgc ccgggagacg
     3481 agtgcggcca ggaccgggcc ggcgggcgga tgcgtcacag gggctcctgt cgtctgcggc
     3541 gggacgggcc gcgatcgtac gaccgccccc gcccgccgcg cggcggaaga ggccgggacg
     3601 gtcggtctgc acgatggcgc tgctaccctt cgtggtcaat tgaccgcttt gcgtaacata
     3661 ggggagtgcg cgtgaagatc gcgtgcgtcg gcggcggacc cgcaagcctg tacttctcga
     3721 tcctgatgaa gcgccaggac ccgtcccacg acatcaccgt ccacgagcgg aaccccgccg
     3781 gatcgaccta cggctggggc gtgacctact ggagcggcct gctcgacaaa ctccgcggga
     3841 gtgaccccga gtcggcgctc gccgtcagcg agaactccgt ccgctggagc gacggagtcg
     3901 cccacgtccg gaaccgcacc acggtccacc acggcgacga gggcttcggc atcggccgcc
     3961 gcagattcct cgacgtactg gccgaccggg cccggtccct gggcgtccgc atcgagtacg
     4021 agcatgagat cggcgccgac gacccactgc ccgaggccga tctggtcgtc gccggcgacg
     4081 gggtcaacag cgtgctgcgc ggccgctacg ccgaccactt cggcagcgag accgtgctcg
     4141 gccgcaaccg ctacatctgg ctcggcacca ccaaggtctt cgactcgttc accttcgcct
     4201 ttgtggagag cgaacacggc tggatctggt gctacggcta tggattcagc gacggccaca
     4261 gcacctgcgt catcgagtgc tccccggaaa cctggaccgg gctcggcctc gaccgggcca
     4321 gcgaggccga cggtctcgcc ctgctggaga agctcttcgc cgacgtcctc gacgggcacg
     4381 agctgatcgg ccgggcgcag agcgacggtg ccgcccagtg gctgaacttc cgcaccctca
     4441 ccaaccgcac ctggcatcgc gacaacctcg tcctgatcgg cgacgccgcc cacaccaccc
     4501 actactccat cggcgcgggc accaccctcg ccctggagga cgccatcgcc ctcgccgaag
     4561 ccctgagcgc gcaccgcgac ctgccgggcg cgctcgccgc ctacgagcgg gaacgcaagt
     4621 ccgcgctcct gcacatccag agcgcggccc ggctcagcgc ccagtggtac gagaacctcc
     4681 cgcgctacat ccgccttccg cccccgcaga tgttcgccct gctcggccag cgccattccc
     4741 cgctgctgcc gtacgtgcct ccgcagctct actaccggat cgaccgggcg gccggacaac
     4801 tggaggcgct gcgcaggctc aagcgctggc tggggccgcg actggcgcgt accgtccagg
     4861 cgcgcacggg ccggtaggcc ggccgccggc ggccgcgtcc gacggagaat tctgggtgaa
     4921 tgaccattca cccggctaag gtgaattcct attcacctcc cttcttcacg tcggctgccg
     4981 cccctggagt gaccatggtc ccgatatcca ccccgtccga ccggtccgcg acccccgacg
     5041 gaccggccgg acggccgggt gtccgcgacc ggctgacggt ccccgtcctg gcgttcggcg
     5101 gaatcctcat ggccgtcatg cagacggtcg tggtgccgct gctgcccgac ctgccgcgcc
     5161 tgaccggcgc ttccgcgggc gccgtctcct ggatggtcac cgccaccctg ctctccggcg
     5221 cggtgctgac cccggtgctc ggccgggccg gcgacatgta cggcaagcgg cgggttctgc
     5281 tcgccgccct cgcgctgatg accctgggct cgctgctgtg cgccgtcacc tccgacatcc
     5341 gcgtgctcat cgccgcgcgg gccctccagg gcgcggcggc cgccgtcgta ccgctgtcga
     5401 tcagcatcct gcgcgacgaa ctcccgcccg agcgcacggg ttccgcggtg gccctgatga
     5461 gttccaccgt gggcatcggc gccgcgctcg gtctgccgat cgccgcgatg atcgtgcagt
     5521 acgccgactg gcacgtcatg ttctgggcga ccaccgggct cggcgccggc ggactggcac
     5581 tggcgtggtg ggcggtgcgc gagtcgcccg tccggcagcc gggccgcttc gacacgctgg
     5641 gtgcgctggg gctggccgcg ggcctggtct gcctgctcct cggtgtgtcg cagggcgggc
     5701 agtggggctg gaccagtccg cggatcgtcg gcctgctcgt ggcctgcgta ctcgtactga
     5761 cgctgtggtg gttccagcag tggcgggccc cgcggcccct ggtggacctg aagctggcct
     5821 cccgcccccg ggtcgccctg ccgcacgtgg ccgcgctgct gaccggattc gccttctacg
     5881 gcaactcgct ggtcacggcg cagctggtgc aggcgcccaa ggccaccggc tacggactcg
     5941 ggctgtccat cgtgcagacc ggtctgtgcc tgctgcccgg cggcgtcatc atgctgctgt
     6001 tctcgccggt ctcggcgcgc atctcggccg cccgcggccc gcgcgtgacg ctggcactcg
     6061 gggccgcggt catcgccgtc ggctacgccg tgcgcatcgc ggacagccgc gacctgtgga
     6121 tgatcatcgt gggcgccacg gtcatcgcgg tcggcacgac cctcgcctac tcggccctgc
     6181 ccaccctgat cctgcgtgcc gtgcccgccg gacagaccgc ctccgccaac ggcgtcaacg
     6241 tcctgatgcg caccatcggc caagccgtgt gcagcgcggc ggtcgccgcc gtcctggtcc
     6301 accacaccag cctggtggga ggcgccccgg tacccaccct gcacggctat ctgctggcgt
     6361 tcgcgatggc gggtacggtc gcagtgatgg cctgcgccgc cgccctcgtc atccccgggg
     6421 accccgactc ccacggcacg cgacgggccc gcggccgtac ccggccgtcc cacgacgagg
     6481 cgctggaagg agcatga
//
