LOCUS       BGC0000909              6625 bp    DNA     linear   BCT 11-OCT-2001
DEFINITION  Streptomyces avermitilis putative melanin biosynthetic gene cluster.
ACCESSION   BGC0000909
VERSION     BGC0000909
KEYWORDS    .
SOURCE      Streptomyces avermitilis
  ORGANISM  Streptomyces avermitilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 14:24:45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6625
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..264
                     /codon_start=1
                     /product="putative secreted protein"
                     /protein_id="BAB69180.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSMVLAGAVAPAAAHAATEVPPASLTGAVNQLTK
                     GPVNLSPLHADNKGSALGTVKGAADSLTQQGNARLIGGLPLG"
     source          1..6625
                     /db_xref="taxon:33903"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces avermitilis"
     subregion       1..6625
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6625
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1061..1447
                     /gene="melC1'"
     CDS             1061..1447
                     /codon_start=1
                     /gene="melC1_"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /product="putative tyrosinase co-factor protein"
                     /protein_id="BAB69181.1"
                     /sec_met_domain="melC (E-value: 1.1e-47, bitscore: 150.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLAPVLAASGSAGPEEARFDETYRGRRIVGDRYDAQRSGDAYSG
                     AWHVTVDGRPLHLMRRADGSWMTMVDHYRSYPTVLAAARAAVDELGPTARLGVPHGGGG
                     HMDDSGTPGGRKGAERDHGSGVHA"
     gene            1434..2297
                     /gene="melC2'"
     CDS             1434..2297
                     /codon_start=1
                     /gene="melC2_"
                     /product="putative tyrosinase"
                     /protein_id="BAB69182.1"
                     /transl_table=11
                     /translation="MYTRKDVSTLTRSERRRLVAALLEVKRRGEYDEFVRMHIKYYVAD
                     GETGLRAAHMAPSFLPWHRMFLLDLERVLRRVDESVTMPYWDWTRSRSRTAAPWTEDLL
                     GGTGRQSDRQVTTGPFAYRHGGWPIKEGITDAEYLMRDLGRSRDPIALPTARDLQGALD
                     DPVYDTAPWNSTSAKGFRNRLEGWGPGRGAASWRNHNRVHRWVGGHMVSGASVNDPVFW
                     MHHAFVDLLWSRWQQRHQGARYLPEQQPARGDAQRGRIVARHERMPPWDVTPDQLEDHS
                     GIYRYA"
     CDS             2850..4454
                     /codon_start=1
                     /product="possible ATP-binding protein"
                     /protein_id="BAB69183.1"
                     /transl_table=11
                     /translation="MTLDVRPQLLDALSALRDRVAAASFPLPLAGAPRARANRDELLAQ
                     LDDYLVPRLRDPEAPLLAVIGGSTGAGKSTLVNSLVGRRVSEAGVLRPTTRTPVLVCHP
                     EDHHWFSGMRVLPDLTRVWVPHQEPGDDLHALVERGERTLRIETAETLPPGLALLDAPD
                     VDSLVADNRVLAAELICAADIWIMVTTAARYADAVPWYLLRTAKENKATLVTVLDRVPH
                     QVVSEVSRQYGALLAKAGLGDVPRFTVPELPESAWGGGLLPATAVATLRTWLIQQVQDP
                     AARQQAMARTAYGVLDSLKSRMPELAGAAAAQYAAALRLTAAVDGAYDSEYARVKGRLQ
                     AGAVLAGDALKRWRAYPLDCTAGELLDALVESLGSLLLCAVTAADERVDEAWRREPASG
                     APELTDRDPTLESAEHRIGMAARRWRRVLEEYAEEEVRNLDKSLAPDAEVVAALVATAL
                     LGGRRARAAGEGLAERIGAHGALRLRDRGGRLLSEYVDTTLHIERERRLAPLDALDVHA
                     EPQAELIAALSVLQKER"
     CDS             4757..6625
                     /codon_start=1
                     /product="putative ATP-binding membrane protein"
                     /protein_id="BAB69184.1"
                     /transl_table=11
                     /translation="MKRGFPPPSAADADASGRTESTEPADSTESGEPWGDGLIARRVSE
                     TADGQQEVAALLETRSKAVQPPEPLAYDGSLRSRLDALRELVGLSRTRLDSRTLAEAGR
                     VLDEAVARRRLSGEHTVVAIAGATGSGKSQLFNVLAGVTISETGVRRPTTAAPIACSWS
                     DGAAPLIDRLGIPGRLRRRPLQSPEGEAQLRGLVLVDLPDHDSAAVQHREQVDRILALV
                     DAVIWVVDPEKYADAVLHERYLRPMAGHAEVTFVVLNQVDRLPGEAAHQVLDDLRRLLD
                     EDGIALGEYGEPGATVLALSALTGDGVGELRESLGQFLAERGAAARRISADVEAAGARL
                     RPVYATGRRTGLSEEARDDFAGRLADAVGATAAGEAAERAWLRNANRACGTPWLRLWRW
                     YQDRSEPTTGRLRVGAPADEEATARQRVEQAVRTVADRAAVGLPAPWAQAVREAAVRGS
                     QGLPEALDELVVRTGSPAGRPPRPGWWPVAVLAQASMTLLQVFGGLWLLGQVIGFMSPN
                     LGVPVLLMVAGIVGGPVVEWSCRLAARGPARRYGLEAERRLREAAGGCGRARVLDPVAA
                     ELLRYREVREQYAKVMGAGAGAGAGAAGVGAGAGAGTGAGVQARVG"
ORIGIN
        1 atgaagtctc tgaaggctgc cgccgtcgtt gccggttcca tggttctggc cggtgcggtc
       61 gcgcccgccg ctgcccacgc cgccacggag gtcccgcccg ccagcctcac cggagcggtg
      121 aaccagctca ccaagggccc cgtcaacctg tcgccgctgc acgcggacaa caagggttcc
      181 gcgctcggca cggtcaaggg ggcggcggac tccctcaccc agcaggggaa cgcccggctg
      241 atcggcggac ttcccctggg ctgagcggtt cgggcgctct tcggtctcag gcctttactc
      301 ggaggccgtc ccgggctttc actccggctt tctgccggac ttgcgcctca agagcctgtg
      361 gacgaactgg ggtcgattcc gccgcatgcg ggatcggccc ttgctctcgg cttttcatgg
      421 cggcccgtcg gtttgtccgg cgggccgctt cgatgtcacg gccttgccga ggggaaacag
      481 taactccact tgcatttagg ggaagttatg ggtcggcggc cctgccgggc gggcggaggc
      541 cggaggtgcg ggctgtccgg actgctcggc ctgttcggtc tgctcggtcg gttcagtctg
      601 ttcggtgttc ggtgttcggt gttcggtctg ttcggctgtg ggtggtcgga gaatccctca
      661 ttcgtgtggt cgtgttggcg cgggtggtcc gctcgggtga acgagcgcat gggtatgttc
      721 cggtgcgtcg atacagttcc gcggtgacct caaccaccag cgaaacgtgc ccttttcgag
      781 ccgccgacct gccgcccctc aaggcccggt gcgccacgcc ggcggaggga ccggcctcct
      841 tcggtcatcc gcgctcaccg ggtctgactc cgggagagcc gtggccgggc ctgcggtcgc
      901 cgaggtcgcg tccgggggag cggtgaccgg ggcggtgaac acagcggccg actccgcgag
      961 ccctgtggcc gactccatgt gtccgcggcc cgccgtcagc cccacggagg tcacgggacg
     1021 gcggcgggtg ctgcgggtgc tgttcgcgct gggggccgga gtgacgctgg cgccggtctt
     1081 ggcggcgtcg gggtcggccg gcccggagga ggcgcggttc gacgagacgt atcgcgggcg
     1141 ccgtatcgtc ggcgacaggt acgacgccca gcggtccggg gacgcctact ccggcgcgtg
     1201 gcacgtcacc gtggacgggc ggccgctgca cttgatgcgc cgggccgacg gcagctggat
     1261 gaccatggtc gaccactacc ggtcgtatcc gacagtgctc gccgccgcgc gcgcggccgt
     1321 cgacgaactc ggccccaccg cacggctggg cgtgccgcac ggcggtggcg gccacatgga
     1381 cgacagcggt acgccgggcg ggcgcaaggg agccgagagg gatcatggca gtggtgtaca
     1441 cgcgtaagga cgtcagcacg ctcacccggt ccgagcggcg tcggctcgtc gccgcactgc
     1501 tcgaggtcaa acgccgcggc gagtacgacg agttcgtgcg catgcacatc aagtactacg
     1561 ttgccgacgg cgagaccggc ctgcgcgccg cccacatggc accctccttc ctgccctggc
     1621 accgcatgtt tctgctggac ctggagcggg tgctgcgccg ggtggacgag tcggtgacca
     1681 tgccgtactg ggactggacg cgcagccgca gccggacggc cgcaccgtgg accgaggacc
     1741 tgctcggcgg caccgggcgg caatccgacc gccaggtcac caccggcccc ttcgcctacc
     1801 gtcacggtgg gtggcccatc aaggagggga tcaccgacgc cgagtacctc atgcgtgacc
     1861 tgggccgctc ccgggacccg atcgcgctgc cgacggccag ggatctgcag ggcgccctcg
     1921 acgatcccgt ctacgacacg gccccgtgga actccacgtc cgccaaagga ttccgcaaca
     1981 ggctggaggg gtggggtccg gggcggggag ccgcttcgtg gcgcaaccac aaccgggtcc
     2041 accgttgggt cggcggccac atggtgagcg gcgcctccgt caacgacccc gtcttctgga
     2101 tgcaccacgc cttcgtcgac ctcctctggt cccgctggca gcagaggcac cagggcgccc
     2161 gctatctccc cgagcagcag cccgcccggg gcgacgccca gcgtggccgc atcgtcgcgc
     2221 ggcacgagag gatgccgccg tgggacgtga caccggacca gctggaggat cacagcggga
     2281 tctaccggta cgcgtagcac gtacgagcac ggggaagccc ctggcggtcg cgtaccgtcg
     2341 ggggcttctc ggctgtggtg ccggctcgga cgccggttca tcgaggacgc gcttggtctc
     2401 agcgctgcgc gaaccggaca cgaagaagcc ccatcggcgt ttccgctggt gaggctgggt
     2461 ttgcgccccc ggcaggactc gaacctgcgg ccaagcgctt agaaggcgcc tgctctatcc
     2521 actgagctac gggggccggg tgtggtggcc tctgtcctgg tgcccgggtg tgggcgggat
     2581 ccgcgacctt gccgggacaa ggatagggct cccgggtcct tgtccctggc gcttcccctc
     2641 cgtggctcga tgtggaggtt cagtgaagcg gtcctgataa tcgcaggcag gtacgaatcg
     2701 tgcaccgctt ttggcgtctg gcgcaccggg tgttgtgcac tcgttatgcc tgcgccccag
     2761 tcgtcccttc cgtcccctgt gtcctgtcgg cgcgcagaca tgtctatatg cttcagaaag
     2821 cctccaaaat tgggcattct tcgcatgtgg tgaccttgga cgtacggcct cagctgctcg
     2881 acgcactctc cgccctgcgc gaccgtgtcg ccgccgcaag ctttccgctg cccctggcgg
     2941 gggctccacg cgcgcgtgcc aaccgcgacg agcttctcgc gcagctcgac gactacttgg
     3001 tgccccggtt gagggacccc gaagcgccgt tgctggccgt catcggggga tccaccgggg
     3061 ccggcaagtc gaccctcgtc aactccctcg tcgggcgcag ggtcagcgag gcgggcgtgc
     3121 tgcggccgac cacccgtacg ccggtgctcg tatgccatcc ggaggaccat cactggttca
     3181 gcgggatgcg cgtactgccc gacctcacgc gcgtgtgggt gccccatcag gaacccgggg
     3241 acgatctgca cgccctggtc gaacgggggg agcggacgct gcgtatcgag accgccgaga
     3301 cgctgccgcc cgggctcgcc ctcctcgacg cgcccgacgt cgactccctc gtcgccgaca
     3361 accgtgtcct cgccgccgag ctgatctgcg ccgcggacat ctggatcatg gtcaccacgg
     3421 ccgcccgcta cgccgacgcg gtgccgtggt atctgctgcg taccgccaag gagaacaagg
     3481 cgaccctggt caccgttctc gaccgggtgc cccatcaggt ggtgtccgag gtctcgcggc
     3541 agtacggggc cctgctcgcc aaggccgggc tcggcgacgt cccccggttc accgtgcccg
     3601 agctgcccga gtccgcgtgg ggcggggggc ttcttccggc caccgcggtg gcgaccctgc
     3661 ggacctggct catccagcag gtgcaggacc ccgccgcccg gcagcaggcc atggcccgta
     3721 cggcgtacgg agtcctcgac tcgctcaagt cgcgcatgcc cgagctggcc ggcgcggcgg
     3781 ccgcacagta cgccgccgcg ctgcgcctca ccgcggccgt cgacggggcg tacgacagcg
     3841 agtacgcgcg cgtgaagggg cgtttgcagg ccggggccgt gctcgcgggt gacgcgctga
     3901 agcgatggcg cgcctatccg ctggactgca ccgccggcga actgctcgac gcgctcgtcg
     3961 aaagcctcgg ctcgctcctg ctgtgcgccg tcacggccgc ggacgagcgc gtcgacgagg
     4021 cctggcggcg cgagcccgcc tcgggtgccc cggagctgac ggaccgtgat cccacgctgg
     4081 agagcgccga acaccggatc gggatggccg cgcgacgctg gcggcgcgtc ctcgaggagt
     4141 acgccgagga agaggtccgc aacctcgaca agagcctcgc gccggacgcc gaggtggtgg
     4201 ccgccctcgt cgccacggcg ctgctgggtg gccggcgggc gcgggccgcc ggagaggggc
     4261 tcgccgagcg gatcggcgcg cacggcgccc tcagactgcg cgaccggggc ggacggctgc
     4321 tctccgagta cgtcgacacg acactgcaca tcgaacgcga gcgccgtctc gcccccctcg
     4381 acgcgctcga cgtgcacgcc gagccacagg ccgaactcat cgccgcgctg tccgtactgc
     4441 agaaggagag gtgaccgcgg tgactgccgt cactgaccac acggatcacg ccgatcatcc
     4501 cgaggacgag cccacggcgg ccgagcgcat ggggggtgac ggcgcgaggg gcgagggcga
     4561 aggcacggga gacgtagcta cgggaggcga aggtacgcgg gatgaacccg tgacggaccg
     4621 gcccgggaag gaccgatcgg ggaaggaccg gcccgggaag gatgagccga cgggggaggg
     4681 ctccggcggg gacaacgccg ccggtgacgc agacggcggg cacgcacgtg tggagcgcga
     4741 tgcgcttcac acacgcgtga agcgcggttt cccgcccccg tcggccgccg acgccgacgc
     4801 gtcgggccgt acggagtcca cggaacccgc ggattccacg gagtccggcg agccctgggg
     4861 cgacgggctg atcgcccggc gcgtgtccga gacggccgac gggcaacagg aggtggccgc
     4921 cctcctggag accaggagca aggccgtcca gccgcccgag cccctcgcgt acgacgggtc
     4981 gttgaggtcg cggttggacg ccctgcgcga gctggtgggg ctgtcgcgga cccggctgga
     5041 cagccggacg ctcgcagagg caggccgggt actggacgag gcggtggcgc ggcgccggct
     5101 gtccggggag cacaccgtcg tcgccatcgc gggcgcgacc ggcagcggca agtcccagct
     5161 cttcaacgtg ctcgccggag tgaccatttc ggaaaccggc gtacgcaggc cgaccaccgc
     5221 ggcgcccatc gcgtgcagct ggagcgacgg cgcggccccg ctcatcgacc ggctcggcat
     5281 ccccggacgg ctgcgcaggc gccccctcca gagccctgaa ggagaggcac aactgcgcgg
     5341 gctcgtcctg gtggacctgc ccgaccacga ttcggcggcc gtgcagcacc gcgaacaggt
     5401 cgaccggatc ctggcgctcg tcgacgcggt catctgggtc gtcgacccgg agaagtacgc
     5461 ggacgccgtc ctccatgagc gctatctgcg gcccatggcg ggacacgccg aggtcacctt
     5521 cgtcgtcctc aaccaggtgg accggctgcc cggcgaggcc gcacaccagg ttctcgacga
     5581 cctcaggagg ctgctcgacg aggacgggat cgctctgggg gagtacggcg agccgggcgc
     5641 gaccgtgctc gcgctgtccg ccctcaccgg ggacggcgtc ggcgaactgc gcgagtcgct
     5701 cgggcagttc ctggccgagc gcggggccgc cgcgcgccgc atctccgccg atgtggaagc
     5761 ggccggtgcg cgcctgcggc ccgtctatgc gaccggtcgg cgtaccggcc tcagcgagga
     5821 ggcgcgcgac gacttcgccg gccggctcgc ggacgcggtg ggtgcgaccg ctgcgggcga
     5881 ggccgccgag cgcgcgtggc tgcgcaacgc caaccgagcg tgcggcacgc cctggctgcg
     5941 gctgtggcgg tggtaccagg accggagcga acccaccacg ggtcgcctca gggtgggcgc
     6001 gcccgcggac gaggaggcga ccgcccgaca gcgcgtggag caggccgtac gtacggtggc
     6061 ggaccgggcc gcggtagggc tgcccgcgcc gtgggcacag gcggtgcgcg aggcggccgt
     6121 acgggggtcg caggggctgc cggaggcgct ggacgagctt gtggtgcgta cggggtcgcc
     6181 ggcggggcgg ccgccgcggc cgggctggtg gccggtcgcc gtgctcgctc aggcgtcgat
     6241 gacgctcctc caggtcttcg gcggcctgtg gctgctgggg caggtgatcg ggttcatgtc
     6301 gccgaatctc ggggtgccgg tgctgttgat ggtcgcgggc atcgtcgggg gacccgttgt
     6361 ggagtggagt tgcaggctgg cggcgcgggg gccggcccgg cggtacggac tcgaggccga
     6421 gcgccggctg agggaggcgg ccggggggtg cggcagggcg cgggtgctgg atccggtggc
     6481 ggcggagctg ctgcggtatc gggaggtgcg ggagcagtac gcgaaggtca tgggggccgg
     6541 ggctggggct ggggccggcg cggctggggt cggcgcggga gccggagccg ggacgggagc
     6601 gggggtgcag gctcgggtgg ggtga
//
