LOCUS       BGC0000910              1420 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0000910
VERSION     BGC0000910
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 21:02:02
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2943455
            Orig. end    :: 2944875
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..867)
                     /gene="SCO2700"
                     /gene_synonym="melC2"
                     /gene_synonym="SCC61A.21c"
     CDS             complement(1..867)
                     /codon_start=1
                     /db_xref="GOA:Q9KYH2"
                     /db_xref="InterPro:IPR002227"
                     /db_xref="InterPro:IPR008922"
                     /db_xref="UniProtKB/TrEMBL:Q9KYH2"
                     /gene="SCO2700"
                     /gene_synonym="melC2"
                     /gene_synonym="SCC61A.21c"
                     /note="SCC61A.21c, melC2, tyrosinase (monophenol
                     monooxygenase), len: 288 aa; strongly similar to many eg.
                     SW:P06845 (TYRO_STRGA) tyrosinase from Streptomyces
                     glaucescens (273 aa) fasta scores; opt: 682, z-score:
                     837.0, E(): 0, 52.0% identity in 277 aa overlap. Contains
                     Pfam match to entry PF00264 tyrosinase, Common central
                     domain of tyrosinase Prosite match to PS00497 Tyrosinase
                     CuA-binding region signature and Prosite match to PS00498
                     Tyrosinase and hemocyanins CuB-binding region signature."
                     /product="tyrosinase (monophenol monooxygenase)"
                     /protein_id="CAB92266.1"
                     /transl_table=11
                     /translation="MAYTRKDVSTLTRTEKRRFVNALLEIKRRGEYDEFVRTHIEYYVS
                     DGENGLRTAHMAPSFLPWHRRFLLDLEEALRRVDPSVTVPYWDWTKDRSAKSAPWTADL
                     LGGTGRRSDHRVTTGPFAHAGGNWTIKVNVTDTEYLTRDLGRAADPLGLPTKSDLEWAL
                     DDPKYDTSPYDSTVRKGFRNKLEGWGAGRGSVSWRNHNRVHRWVGGAMVGGASVNDPVF
                     WLHHAFIDLQWSRWQARHRGARYLPAEPPGRGSAQRGRIVARHEKLPPWDVTPDELEDV
                     GRIYRYA"
     subregion       1..1420
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..1420
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    complement(115..714)
                     /gene="SCO2700"
                     /gene_synonym="melC2"
                     /gene_synonym="SCC61A.21c"
                     /note="Pfam match to entry PF00264 tyrosinase, Common
                     central domain of tyrosinase, score 144.70, E-value
                     2.1e-40"
     misc_feature    complement(178..213)
                     /gene="SCO2700"
                     /gene_synonym="melC2"
                     /gene_synonym="SCC61A.21c"
                     /note="PS00498 Tyrosinase and hemocyanins CuB-binding
                     region signature"
     misc_feature    complement(652..705)
                     /gene="SCO2700"
                     /gene_synonym="melC2"
                     /gene_synonym="SCC61A.21c"
                     /note="PS00497 Tyrosinase CuA-binding region signature"
     gene            complement(851..1420)
                     /gene="SCO2701"
                     /gene_synonym="melC1"
                     /gene_synonym="SCC61A.22c"
     CDS             complement(851..1420)
                     /codon_start=1
                     /db_xref="GOA:Q9KYH1"
                     /db_xref="InterPro:IPR010928"
                     /db_xref="UniProtKB/TrEMBL:Q9KYH1"
                     /gene="SCO2701"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /gene_synonym="melC1"
                     /gene_synonym="SCC61A.22c"
                     /note="SCC61A.22c, melC1, tyrosinase co-factor, len: 189
                     aa; similar to others from Streptomyces spp. e.g. SW:P55047
                     (TYRT_STRGA) tyrosinase co-factor from Streptomyces
                     glaucescens (134 aa) fasta scores; opt: 304, z-score:
                     323.4, E(): 1.5e-10, 44.4% identity in 133 aa overlap"
                     /product="tyrosinase co-factor"
                     /protein_id="CAB92267.1"
                     /sec_met_domain="melC (E-value: 1e-55, bitscore: 175.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGNAGATANGAEREYATEDPARGGPASGTRRQVMRGLFAPALAV
                     GLAPLIAASRPSGAAEAATTGPLPAHPGPHAAESAESVEGAAEGVEGAAFDETYRGRRI
                     RGIRSAAGRAVGAGTWQVTVDGRPLHLMRRADGSWLSMVDHYRSYPTPLAAARGAVDEL
                     GPGEHLRDTPSTDHGRHSGGRHGVHA"
     regulatory      complement(869..877)
                     /gene="SCO2701"
                     /gene_synonym="melC1"
                     /gene_synonym="SCC61A.22c"
                     /regulatory_class="ribosome_binding_site"
ORIGIN
        1 tcaggcgtag cggtagatcc ggccgacgtc ctccagttcg tccggtgtca cgtcccacgg
       61 cggcagcttc tcgtgccgtg cgacgatccg tccgcgctgt gcgctgcccc ggccgggcgg
      121 ctcggcgggc aggtagcggg cgccgcggtg gcgggcctgc cagcgggacc actggaggtc
      181 gatgaaggcg tggtgcagcc agaacaccgg gtcgttgacg gaggcgccgc cgaccatggc
      241 cccgccgacc cagcggtgga cccggttgtg gttgcgccag gacacgctgc cgcggcccgc
      301 cccccacccc tccagcttgt tgcggaaccc cttgcggacc gtggagtcgt agggcgaggt
      361 gtcgtacttc gggtcgtcca gcgcccactc caggtcgctc ttggtgggca ggccgagggg
      421 gtcggcggca cgtcccaggt cccgggtgag gtactcggtg tcggtgacgt tcaccttgat
      481 ggtccagttc cccccggcgt gggcgaaggg gccggtggtc acccggtggt cggaccgtcg
      541 cccggtgccg ccgaggaggt ctgcggtcca gggcgccgac ttggcgctgc ggtccttcgt
      601 ccagtcccag tacggcaccg tgaccgacgg gtcgacccgg cgcagcgcct cctccaggtc
      661 cagcaggaac cggcggtgcc agggcaggaa ggacggcgcc atgtgcgccg tacgcaggcc
      721 gttctcgccg tcggagacgt agtactcgat gtgggtgcgc acgaactcgt cgtactcccc
      781 gcgtcgtttg atctccagca gcgcgttgac gaaccgccgc ttctcggtgc gggtcagcgt
      841 gctgacgtcc ttacgcgtgt acgccatgcc gccccccgga gtgccggccg tggtccgtgg
      901 acggcgtgtc gcgcaggtgc tcgccggggc cgagttcgtc gacggcgccg cgggccgcgg
      961 cgagcggggt ggggtacgac cggtagtggt cgaccatgct cagccagctg ccgtccgccc
     1021 ggcgcatcag gtgcagcggc ctgccgtcca cggtgacctg ccaggtaccg gcgcccaccg
     1081 cccgccccgc ggccgagcgg atgccccgga tgcgccggcc gcggtaggtc tcgtcgaagg
     1141 cggcgccctc gaccccctcg gctgcccctt caacggactc ggcggactcg gcggcgtgcg
     1201 gcccgggatg ggcgggcagc ggtccggtgg tggcggcctc cgcggccccg gagggtcgcg
     1261 aggcggcgat caggggcgcc aggccgacgg cgagggccgg ggcgaacagc ccccgcatca
     1321 cctgccgtcg ggtgccggac gccggcccgc ctctcgccgg gtcctccgtc gcgtactccc
     1381 gctcggcgcc gttcgccgtc gcgcccgcgt tgccgaccat
//
