LOCUS       BGC0000914             19342 bp    DNA     linear   BCT 06-FEB-2015
DEFINITION  Streptomyces coelicolor plasmid SCP1.
ACCESSION   BGC0000914
VERSION     BGC0000914
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
COMMENT     On or before Apr 14, 2010 this sequence version replaced
            AL590463.1, AL590464.1.
            Notes:
            Streptomyces coelicolor sequencing at The Sanger Centre is funded
            by the BBSRC and Beowulf Genomics
            Details of S. coelicolor sequencing at the Sanger Centre are
            available on the World Wide Web.
            (URL; http://www.sanger.ac.uk/Projects/S_coelicolor/) The more
            significant matches with motifs in the PROSITE database are also
            included but some of these may be fortuitous. The length in codons
            is given for each CDS.
            Usually the highest scoring match found by fasta -o is given for
            CDS which show significant similarity to other CDS in the database.
            The position of possible ribosome binding site sequences are given
            where these have been used to deduce the initiation codon. Gene
            prediction is based on positional base preference in codons using a
            specially developed Hidden Markov Model (Krogh et al., Nucleic
            Acids Research, 22(22):4768-4778(1994)) and the FramePlot program
            of Bibb et al., Gene 30:157-66(1984).
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:25:28
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..525)
                     /gene="mmyF"
                     /gene_synonym="SCP1.228c"
     CDS             complement(1..525)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36752"
                     /db_xref="EnsemblGenomes-Tr:CAC36752"
                     /db_xref="GOA:Q7API8"
                     /db_xref="InterPro:IPR002563"
                     /db_xref="InterPro:IPR012349"
                     /db_xref="UniProtKB/TrEMBL:Q7API8"
                     /gene="mmyF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 145.2; E-value: 2.3e-44)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.228c"
                     /note="SCP1.228c, mmyF, possible oxidoreductase, len:
                     174aa; previously sequenced and annotated as TR:Q9JN75
                     (EMBL:AJ276673). Similar to many oxidoreductases eg.
                     N-terminal region of SW:P54990 (NTAB_CHEHE)
                     nitrilotriacetate monooxygenase component B (EC 1.14.13.-)
                     from Chelatobacter heintzii (322 aa) fasta scores; opt:
                     419, z-score: 522.1, E(): 1.3e-21, 41.4% identity in 169 aa
                     overlap and SW:Q02058 (DIM6_STRCO) actinorhodin polyketide
                     dimerase from Streptomyces coelicolor (177 aa) fasta
                     scores; opt: 295, z-score: 373.9, E(): 2.3e-13, 31.0%
                     identity in 158 aa overlap. Contains Pfam match to entry
                     PF01613 Flavin_Reduct, Flavin reductase like domain."
                     /product="putative oxidoreductase, MmyF"
                     /protein_id="CAC36752.1"
                     /transl_table=11
                     /translation="MATDVTTATAKPPLATIDSAHFRRVLGHFPTGVVVITAMADGEPA
                     GLAVGSFASVSLDPPMVGFFPGKSSTSWPLVQRAGSFVVNVLGDHQQDVCRAFATSGGD
                     KFTGIPWRRASNGAPALHDVIAWIECDIDTVTDAGDHWFVLGRVRDLALSTNTESPLLF
                     FQGRYARVGAA"
     protocluster    1..19342
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[4734:13706]"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4735..13706
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
     cand_cluster    1..19342
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(mmyO or AvrD)"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="furan"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..19342
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000914"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19342
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="furan"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="(mmyO or AvrD)"
                     /rules="AfsA"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    complement(10..450)
                     /gene="mmyF"
                     /gene_synonym="SCP1.228c"
                     /note="Pfam match to entry PF01613 Flavin_Reduct, Flavin
                     reductase like domain, score 188.10, E-value 1.4e-52"
     regulatory      complement(531..536)
                     /regulatory_class="ribosome_binding_site"
     gene            complement(556..1017)
                     /gene="mmyY"
                     /gene_synonym="SCP1.229c"
     CDS             complement(556..1017)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36753"
                     /db_xref="EnsemblGenomes-Tr:CAC36753"
                     /db_xref="GOA:Q7API7"
                     /db_xref="UniProtKB/TrEMBL:Q7API7"
                     /gene="mmyY"
                     /gene_synonym="SCP1.229c"
                     /note="SCP1.229c, mmyY, hypothetical protein, len: 153aa;
                     previously partially sequenced and annotated as TR:Q9JN76
                     (EMBL:AJ276673)."
                     /product="hypothetical protein, MmyY"
                     /protein_id="CAC36753.1"
                     /transl_table=11
                     /translation="MTDQQLRDRYAIIELCTRMAWHLDHCEWDQLVDLFTDEIRLDYTS
                     LNGGEPVTLPRKDVIGKWRSNREGLQATQHLLSNHLVTVDGATAHTTAMFQATHLLPNP
                     FGGPTWTLGGEYRYGLVRTADGWRISALTMNILWADGNRHIRDLALQDG"
     regulatory      complement(1022..1029)
                     /regulatory_class="ribosome_binding_site"
     regulatory      1240..1243
                     /regulatory_class="ribosome_binding_site"
     gene            1248..2189
                     /gene="mmyB"
                     /gene_synonym="SCP1.230"
     CDS             1248..2189
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36754"
                     /db_xref="EnsemblGenomes-Tr:CAC36754"
                     /db_xref="GOA:Q9ACS4"
                     /db_xref="InterPro:IPR001387"
                     /db_xref="InterPro:IPR010982"
                     /db_xref="UniProtKB/TrEMBL:Q9ACS4"
                     /gene="mmyB"
                     /gene_synonym="SCP1.230"
                     /note="SCP1.230, mmyB, possible DNA-binding protein, len:
                     313aa; previously sequenced and annotated as TR:Q9JN77
                     (EMBL:AJ276673). Similar to many from Streptomyces
                     coelicolor eg. TR:Q9RDF4 (EMBL:AL136503) putative
                     DNA-binding protein (294 aa) fasta scores; opt: 670,
                     z-score: 810.9, E(): 0, 43.1% identity in 255 aa overlap.
                     Contains helix-turn-helix motif at residue 52-73 (Score
                     1329 (+3.71 SD)). Contains a TTA encoded leucine at residue
                     23, possible target for bldA regulation."
                     /product="putative DNA-binding protein, MmyB"
                     /protein_id="CAC36754.1"
                     /transl_table=11
                     /translation="MASVDGVAKDSTVCSPKRQREALRHFLRSRRARLSPDDVGLLATG
                     RRHTPGLRREEVAVIAGVSASWYTWLEQGRDIKVSDGVLNAISQALRLDDTERAHLYRL
                     AGVNPPQSVPATAGQTETSRLQLIVDGWLPAPAFVVDRYWNTLAANQAARSALGVGAGD
                     QNYLAAFFTEPTARARYLDWDKLATRLVGQFRVQAARFPEDPRFDRIARQLCATDHAFA
                     DLWARHETCDTAMTSVRVRPPGEESMRFEHLILALLENADLRLMLYMPRGAHISAEAGL
                     RLVPADPLTRNSLLQLPGRPMTSRPVERHIHP"
     misc_feature    1314..1316
                     /gene="mmyB"
                     /gene_synonym="SCP1.230"
                     /note="tta leucine codon, possible target for bldA
                     regulation."
     misc_feature    1314..1316
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     regulatory      2262..2269
                     /regulatory_class="ribosome_binding_site"
     gene            2276..2929
                     /gene="mmyQ"
                     /gene_synonym="SCP1.231"
     CDS             2276..2929
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36755"
                     /db_xref="EnsemblGenomes-Tr:CAC36755"
                     /db_xref="GOA:Q7API6"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR028939"
                     /db_xref="UniProtKB/TrEMBL:Q7API6"
                     /gene="mmyQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.231"
                     /note="SCP1.231, mmyQ, hypothetical protein, len: 217aa;
                     previously sequenced and annotated as TR:Q9JN78
                     (EMBL:AJ276673). Similar to TR:Q9L1E0 (EMBL:AL157916)
                     hypothetical protein from Streptomyces coelicolor (220 aa)
                     fasta scores; opt: 314, z-score: 377.8, E(): 1.4e-13, 35.2%
                     identity in 199 aa overlap."
                     /product="hypothetical protein, MmyQ"
                     /protein_id="CAC36755.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 5.3e-09, bitscore:
                     26.1, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTSTSLRIGVLGAGNIGRPIGRHWAVAGHEVAFGSRTPDQLTE
                     FAGALRPAARATTLAEAVETSDVLLLSVPYSAWDDLLQAVGDRLAGKLVIDATNPMGLS
                     EEGRIISTLDQGITQGRNSAKLLPEATVVRAFTHIMDELLWSRGTQQKHFWGMAYAGDD
                     VDAKEVVARLIHDAGFSPVDLGGLDDSAALDPGGAIFPHMFTPADLRAAAGLSA"
     gene            2999..4162
                     /gene="mmyE"
                     /gene_synonym="SCP1.232"
     CDS             2999..4162
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36756"
                     /db_xref="EnsemblGenomes-Tr:CAC36756"
                     /db_xref="GOA:Q7API5"
                     /db_xref="InterPro:IPR001155"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="UniProtKB/TrEMBL:Q7API5"
                     /gene="mmyE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     323.2; E-value: 3.2e-98)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.232"
                     /note="SCP1.232, mmyE, possible enoyl reductase, len:
                     387aa; previously sequenced and annotated as TR:Q9JN79
                     (EMBL:AJ276673). Similar to SW:P77258 (NEMA_ECOLI)
                     N-ethylmaleimide reductase (EC 1.-.-.-) from Escherichia
                     coli (365 aa) fasta scores; opt: 507, z-score: 566.6, E():
                     4.3e-24, 31.6% identity in 380 aa overlap. Contains Pfam
                     match to entry PF00724 oxidored_FMN, NADH:flavin
                     oxidoreductase / NADH oxidase family."
                     /product="putative enoyl reductase, MmyE"
                     /protein_id="CAC36756.1"
                     /transl_table=11
                     /translation="MHVPSTAPPPATAAPLFGPFTVGSLALENRIVMAPMTRELSPGGV
                     PGPEVAAYYARRARNGVGLIITEGAAIGHPSSERRAAVPRIHSADALAGWTRVTQAVHA
                     AGGRIAAQLMHVGLDPLLWGMTPAEMDAASPAGFELLSPSGVDPSQPAAATVGREMSDV
                     DISSVIEAYARAAAEARQAGFDAIELHAAHGYLIDQFFWAVTNRRKDRYGGDLSARTRF
                     GADVVRACRHAVGEDFPIFLRFSQWKVGHYAARLADSPDELAAVLGPLVQAGVDAFHCS
                     TRRFWQPEFEGSDLNLAGWTKKVTGRPVIAVGSVGLKDSDFLSYLDGKGADVGDVSVVA
                     DRLAQGEFDLVAVGRALIADPAWPAKVRGGRSADLIPFDARMLTSLH"
     misc_feature    3041..4120
                     /gene="mmyE"
                     /gene_synonym="SCP1.232"
                     /note="Pfam match to entry PF00724 oxidored_FMN,
                     NADH:flavin oxidoreductase / NADH oxidase family, score
                     250.80, E-value 1.8e-71"
     regulatory      4726..4730
                     /regulatory_class="ribosome_binding_site"
     gene            4735..5754
                     /gene="mmyD"
                     /gene_synonym="SCP1.233"
     CDS             4735..5754
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36757"
                     /db_xref="EnsemblGenomes-Tr:CAC36757"
                     /db_xref="GOA:Q7API4"
                     /db_xref="InterPro:IPR008799"
                     /db_xref="UniProtKB/TrEMBL:Q7API4"
                     /gene="mmyD"
                     /gene_functions="biosynthetic (rule-based-clusters) furan:
                     AvrD"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCP1.233"
                     /note="SCP1.233, mmyD, hypothetical protein, len: 339aa;
                     previously sequenced and annotated as TR:Q9JN80
                     (EMBL:AJ276673). Similar to TR:Q52426 (EMBL:L11334) AvrD,
                     avirulence protein from Pseudomonas syringae (311 aa) fasta
                     scores; opt: 253, z-score: 309.5, E(): 9e-10, 31.4%
                     identity in 334 aa overlap."
                     /product="hypothetical protein, MmyD"
                     /protein_id="CAC36757.1"
                     /sec_met_domain="AvrD (E-value: 1.9e-146, bitscore: 478.0,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVSGSLSQKLFHRSVDDVLGPRERRFFGEGFKRAEHRLRHIFVT
                     YGPEGRAQADARVSVDYPSDWSRKGDADQRPHLSTVDVLVIGAQLSEVHLAHVLGLSPD
                     QRARAVLQRVRIKAGRSPVEEDLAGFAASAQLVATIPSDRVVGLFLSTVECVVGTLRMR
                     CEIRHEAGVPHQAAGSYDSLRGLLGDPRLRLFGEGFTSRRQLVEDVVIDPQARQAAAAV
                     RVIRDEDAPSPATGLEGAHHDRASAIDAFVIGLQLGQVLLYTLDEVPRAQSNTLWMRET
                     ILELDPLRPPLPATAPVTTRLDRCKRLETGKGDIWRSADIVGEFLGVRLRCSVAHRLP"
     gene            5866..6570
                     /gene="mmyX"
                     /gene_synonym="SCP1.233A"
     CDS             5866..6570
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36758"
                     /db_xref="EnsemblGenomes-Tr:CAC36758"
                     /db_xref="GOA:Q7API3"
                     /db_xref="UniProtKB/TrEMBL:Q7API3"
                     /gene="mmyX"
                     /gene_synonym="SCP1.233A"
                     /note="SCP1.233A, mmyX, possible ATP/GTP-binding protein,
                     len: 234aa; previously sequenced and annotated as TR:Q9JN81
                     (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.236
                     MmyK, putative ATP/GTP-binding protein (206 aa)(previously
                     sequenced as TR:Q9JN85 (EMBL:AJ276673) hypothetical
                     protein) fasta scores; opt: 538, z-score: 647.7, E():
                     1.3e-28, 42.7% identity in 199 aa overlap. Contains Prosite
                     match to PS00017 ATP/GTP-binding site motif A (P-loop)."
                     /product="putative ATP/GTP-binding protein, MmyX"
                     /protein_id="CAC36758.1"
                     /transl_table=11
                     /translation="MNLAISGTYSVGKTLTTMAVSHLTGLPRSAAKTMRELLPISVPGK
                     TLEECTASEIIMLIMRRNQERAVNESHLPRGFVSDGSSLHEWCYGTVRVLVGINPNDSV
                     NLENVEMTDDIRFFSQVMDQMGVPAKQHAKASYNSFVHLPIEFPLVEDGHRPVNERFRS
                     LADEMLLKVLDELQIPVHIVGGTIPERLQKIMDIYDFTPQMSIDEAITRAQEDYAKIDT
                     TSETDRAPVAAA"
     misc_feature    5884..5907
                     /gene="mmyX"
                     /gene_synonym="SCP1.233A"
                     /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
     gene            6567..7565
                     /gene="mmyC"
                     /gene_synonym="SCP1.233B"
     CDS             6567..7565
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36759"
                     /db_xref="EnsemblGenomes-Tr:CAC36759"
                     /db_xref="GOA:Q9JN82"
                     /db_xref="InterPro:IPR004655"
                     /db_xref="InterPro:IPR013747"
                     /db_xref="InterPro:IPR013751"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /gene="mmyC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 357; E-value: 1.4e-108)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.233B"
                     /note="SCP1.233B, mmyC, possible acyl carrier protein
                     synthase, len: 332aa; previously sequenced and annotated as
                     putative condensing protein TR:Q9JN82 (EMBL:AJ276673).
                     Similar to many predicted acyl carrier protein synthases
                     eg. TR:O54151 (EMBL:AL021409) putative
                     3-oxoacyl-[acyl-carrier-protein] synthase from Streptomyces
                     coelicolor (335 aa) fasta scores; opt: 1184, z-score:
                     1362.6, E(): 0, 57.8% identity in 332 aa overlap."
                     /product="putative acyl carrier protein synthase, MmyC"
                     /protein_id="CAC36759.1"
                     /sec_met_domain="fabH (E-value: 7.1e-110, bitscore: 357.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGAGVLAGLGTALPARLVTNEELSRHLDTDDEWIRSRTGIGQRY
                     WSDGASTGDLAVEAGQRALKAAGTDTVDLVVLATTTPDHPCPATAPDVADRLGLSGVAA
                     YDIAAVCSGFIYGLASAVAHITAGLVGSALVIGAETYSTILDPLDRTTSVIFGDGAGAV
                     VLRSGSVDERGAFLGFDLGSDGALKDLIVIPGGGSRERAAAERPQPAGAYFTMQGKPVF
                     RHAVTRMTSSAGALLDRTGWSPASVDRFVGHQANARILHAVADQLRIDGARTVIDLDRV
                     GNTSAASIPLALSRACGEGLLSPGDRVLLSAFGGGLTWGSTALLWPDITAL"
     regulatory      7617..7622
                     /regulatory_class="ribosome_binding_site"
     gene            7629..7877
                     /gene="mmyA"
                     /gene_synonym="SCP1.234"
     CDS             7629..7877
                     /NRPS_PKS="Domain: PP-binding (7-71). E-value: 1.4e-14.
                     Score: 46.2. Matches aSDomain:
                     nrpspksdomains_mmyA_PP-binding.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36760"
                     /db_xref="EnsemblGenomes-Tr:CAC36760"
                     /db_xref="GOA:Q7API2"
                     /db_xref="InterPro:IPR003231"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:Q7API2"
                     /gene="mmyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.234"
                     /note="SCP1.234, mmyA, possible acyl carrier protein, len:
                     82aa; previously sequenced and annotated as hypothetical
                     protein TR:Q9JN83 (EMBL:AJ276673). Similar to many acyl
                     carrier proteins eg. TR:Q54497 (EMBL:AJ224512) acyl carrier
                     protein from Streptomyces nogalater (86 aa) fasta scores;
                     opt: 146, z-score: 218.3, E(): 0.00011, 41.0% identity in
                     78 aa overlap. Contains Pfam match to entry PF00550
                     pp-binding, Phosphopantetheine attachment site."
                     /product="putative acyl carrier protein, MmyA"
                     /protein_id="CAC36760.1"
                     /sec_met_domain="PP-binding (E-value: 5.4e-15, bitscore:
                     46.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESTVARIIAIICEHFDTGDTEVSAATDFESLEFDSLVLVELAV
                     ILTREFGVEVTDDELADGRTIGEAAAVVARKSTALAR"
     misc_feature    7647..7847
                     /gene="mmyA"
                     /gene_synonym="SCP1.234"
                     /note="Pfam match to entry PF00550 pp-binding,
                     Phosphopantetheine attachment site, score 37.10, E-value
                     1.3e-08"
     aSDomain        7650..7841
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mmyA_PP-binding.1"
                     /evalue="1.40E-14"
                     /label="mmyA_PP-binding.1"
                     /locus_tag="mmyA"
                     /protein_end="71"
                     /protein_start="7"
                     /score="46.2"
                     /tool="antismash"
                     /translation="RIIAIICEHFDTGDTEVSAATDFESLEFDSLVLVELAVILTREFG
                     VEVTDDELADGRTIGEAAA"
     stem_loop       7918..7962
                     /note="Score 51: 17/17 (100%) matches, 0 gaps, 11 base
                     loop"
     regulatory      7992..7996
                     /regulatory_class="ribosome_binding_site"
     gene            8001..8699
                     /gene="mmyP"
                     /gene_synonym="SCP1.235"
     CDS             8001..8699
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36761"
                     /db_xref="EnsemblGenomes-Tr:CAC36761"
                     /db_xref="GOA:Q7API1"
                     /db_xref="InterPro:IPR006383"
                     /db_xref="InterPro:IPR006385"
                     /db_xref="InterPro:IPR023214"
                     /db_xref="UniProtKB/TrEMBL:Q7API1"
                     /gene="mmyP"
                     /gene_synonym="SCP1.235"
                     /note="SCP1.235, mmyP, hypothetical protein, len: 232aa;
                     previously sequenced and annotated as TR:Q9JN84
                     (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.245
                     mmfP (previously sequenced as TR:Q9JN92 (EMBL:AJ276673))
                     fasta scores; opt: 453, z-score: 556.3, E(): 1.6e-23, 38.9%
                     identity in 234 aa overlap."
                     /product="hypothetical protein, MmyP"
                     /protein_id="CAC36761.1"
                     /transl_table=11
                     /translation="MPDVPRSAAFFDIDGTLTATTTMFDFLAHHLSLHGRPSEYAALHG
                     RLRAMTEAGAGRADRCRAYYRVYAGVEERGLLAEGERWFLDRVRTPGFFHEPARAAFDA
                     HAAAGDLTVLVSGSFDACLEPLAEHLGADVLLCSRPEVHDGRYTGALTTPMIGAAKAAA
                     VSALVAERSLSLKDSHAYGDHVSDVPFMELVGHPVVVGRDPRMRCHARAHGWRCLEDSP
                     LPGTAGGSRS"
     gene            8696..9316
                     /gene="mmyK"
                     /gene_synonym="SCP1.236"
     CDS             8696..9316
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36762"
                     /db_xref="EnsemblGenomes-Tr:CAC36762"
                     /db_xref="GOA:Q7API0"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:Q7API0"
                     /gene="mmyK"
                     /gene_synonym="SCP1.236"
                     /note="SCP1.236, mmyK, possible ATP/GTP-binding protein,
                     len: 206aa; previously sequenced and annotated as TR:Q9JN85
                     (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.233A
                     MmyX, putative ATP/GTP-binding protein (234 aa) (previously
                     sequenced as TR:Q9JN81 (EMBL:AJ276673) hypothetical
                     protein) fasta scores; opt: 538, z-score: 647.7, E():
                     1.3e-28, 42.7% identity in 199 aa overlap. Contains Prosite
                     match to PS00017 ATP/GTP-binding site motif A (P-loop)."
                     /product="putative ATP/GTP-binding protein, MmyK"
                     /protein_id="CAC36762.1"
                     /transl_table=11
                     /translation="MTLNRPMRIAVVGAYGNGKTTLTTELSRRLGLPRTHGAAMRDPAG
                     GSGKSLEECTDPELIQLAVRRFTERVVDEARCSRGFVSDGSVLHEWIYTKVRLVLGRLP
                     GPSARLEPVIRSAATAAYEEVIDQIGLLTQQHAFDTYDLVVHLQADVPLPEGHRPISEH
                     FRRVSDQLLRDTLEAWRIPCHVVTGSVQERVRRCRELVDTRSA"
     misc_feature    8732..8755
                     /gene="mmyK"
                     /gene_synonym="SCP1.236"
                     /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
     gene            complement(9379..10806)
                     /gene="mmr"
                     /gene_synonym="SCP1.237c"
     CDS             complement(9379..10806)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36763"
                     /db_xref="EnsemblGenomes-Tr:CAC36763"
                     /db_xref="GOA:P11545"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR016196"
                     /db_xref="InterPro:IPR020846"
                     /gene="mmr"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 329.9; E-value:
                     3.2e-100)"
                     /gene_kind="transport"
                     /gene_synonym="SCP1.237c"
                     /note="SCP1.237c, mmr, methylenomycin A resistance protein,
                     len: 475aa; previously sequenced and annotated as
                     hypothetical protein SW:P11545 (MMR_STRCO) (EMBL:AJ276673).
                     Similar to many others eg. SW:P39886 (TCMA_STRGA)
                     tetracenomycin C resistance and export protein from
                     Streptomyces glaucescens (538 aa) fasta scores; opt: 797,
                     z-score: 882.3, E(): 0, 32.7% identity in 425 aa overlap.
                     Contains multiple possible membrane-spanning hydrophobic
                     regions."
                     /product="methylenomycin A resistance protein, Mmr"
                     /protein_id="CAC36763.1"
                     /transl_table=11
                     /translation="MTTVRTGGAQTAEVPAGGRRDVPSGVKITALATGFVMATLDVTVV
                     NVAGATIQESLDTTLTQLTWIVDGYVLTFASLLMLAGGLANRIGAKTVYLWGMGVFFLA
                     SLACALAPTAETLIAARLVQGAGAALFMPSSLSLLVFSFPEKRQRTRMLGLWSAIVATS
                     SGLGPTVGGLMVSAFGWESIFLLNLPIGAIGMAMTYRYIAATESRATRLAVPGHLLWIV
                     ALAAVSFALIEGPQLGWTAGPVLTAYAVAVTAAALLALREHRVTNPVMPWQLFRGPGFT
                     GANLVGFLFNFALFGSTFMLGLYFQHARGATPFQAGLELLPMTIFFPVANIVYARISAR
                     FSNGTLLTAFLLLAGAASLSMVTITASTPYWVVAVAVGVANIGAGIISPGMTAALVDAA
                     GPENANVAGSVLNANRQIGSLVGIAAMGVVLHSTSDWDHGAAISFLAVGLAYLLGGLSA
                     WRLIARPERRSAVTAAT"
     protocluster    10526..19342
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[15525:16587]"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      15526..16587
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     cand_cluster    10526..19342
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     regulatory      complement(10816..10820)
                     /regulatory_class="ribosome_binding_site"
     regulatory      11008..11013
                     /regulatory_class="ribosome_binding_site"
     gene            11023..11358
                     /gene="mmyJ"
                     /gene_synonym="SCP1.238"
     CDS             11023..11358
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36764"
                     /db_xref="EnsemblGenomes-Tr:CAC36764"
                     /db_xref="GOA:Q7APH9"
                     /db_xref="InterPro:IPR001845"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="UniProtKB/TrEMBL:Q7APH9"
                     /gene="mmyJ"
                     /gene_synonym="SCP1.238"
                     /note="SCP1.238, mmyJ, hypothetical protein, len: 111aa;
                     previously sequenced and annotated as TR:Q52517
                     (EMBL:AJ276673). Similar to many others eg. TR:O31480
                     (EMBL:Z99106) hypothetical protein from Bacillus subtilis
                     (104 aa) fasta scores; opt: 279, z-score: 375.5, E():
                     1.9e-13, 45.4% identity in 97 aa overlap."
                     /product="hypothetical protein, MmyJ"
                     /protein_id="CAC36764.1"
                     /transl_table=11
                     /translation="MAARITTERITDHPDADAITLQGVLDALVDPVRRSIVRQLAKAPE
                     DIACGTFDITVSRSTGTHHFKVLRQAGIIRQYYIGTSKMNTLRTDDLDQAFPGLLTAIV
                     DAAARES"
     gene            complement(11321..12502)
                     /gene="mmyG"
                     /gene_synonym="SCP1.239c"
     CDS             complement(11321..12502)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36765"
                     /db_xref="EnsemblGenomes-Tr:CAC36765"
                     /db_xref="GOA:Q9ACS3"
                     /db_xref="InterPro:IPR000683"
                     /db_xref="InterPro:IPR004104"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9ACS3"
                     /gene="mmyG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 172.9; E-value: 1.9e-52)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.239c"
                     /note="SCP1.239c, mmyG, possible oxidoreductase, len:
                     393aa; previously sequenced and annotated as TR:Q9JN86
                     (EMBL:AJ276673). Similar to many eg. TR:Q9RK99
                     (EMBL:AL117322) putative oxidoreductase from Streptomyces
                     coelicolor (371 aa) fasta scores; opt: 675, z-score: 754.9,
                     E(): 0, 36.4% identity in 357 aa overlap. Contains Pfam
                     match to entry PF01408 GFO_IDH_MocA, Oxidoreductase
                     family."
                     /product="putative oxidoreductase, MmyG"
                     /protein_id="CAC36765.1"
                     /transl_table=11
                     /translation="MATEPIRIGVVGASPDRGWAADAHLPALQHLPQYKITAVGTRRAD
                     SAHRAARRYGATHAFTDPRSLAAHPDVELVAIVVKVPDHARLVEAALAAGKHVLCEWPL
                     ARTTEEAAQLTAAAHGAGVVNAVGLQARHTPTVVRARELIRQGYVGRVTSVTVYSTRGV
                     AAGGRLPAAFAYTLDSTNGAGTLEVAGGHTLDAVQYLLGREMTGLSAALSVQHPRITLD
                     EDARQTGATSPDHVALHATLEGGAALVVHIHDAKNSGAGTRIEISGTQGELAIVSTGPR
                     SGSGLQISELALLGAQGTEPSGQELPFPGSWGTAVPADGLDAAQHTMAVQYAALAADIR
                     EGGSRVPRFADGIELHRLLDAVRLSSATGCRLERRAGERWPVSSPWPRRRRSR"
     misc_feature    complement(11702..12487)
                     /gene="mmyG"
                     /gene_synonym="SCP1.239c"
                     /note="Pfam match to entry PF01408 GFO_IDH_MocA,
                     Oxidoreductase family, score 134.40, E-value 2.1e-36"
     regulatory      complement(12518..12521)
                     /regulatory_class="ribosome_binding_site"
     gene            complement(12585..13706)
                     /gene="mmyO"
                     /gene_synonym="SCP1.240c"
     CDS             complement(12585..13706)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36766"
                     /db_xref="EnsemblGenomes-Tr:CAC36766"
                     /db_xref="GOA:Q7APH8"
                     /db_xref="InterPro:IPR011251"
                     /db_xref="UniProtKB/TrEMBL:Q7APH8"
                     /gene="mmyO"
                     /gene_functions="biosynthetic (rule-based-clusters) furan:
                     mmyO"
                     /gene_functions="other (smcogs) SMCOG1251:luciferase family
                     protein (Score: 159.1; E-value: 2.7e-48)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCP1.240c"
                     /note="SCP1.240c, mmyO, possible monooxygenase, len: 373aa;
                     previously sequenced and annotated as putative alkanal
                     monooxygenase TR:Q9JN87 (EMBL:AJ276673). Similar to weakly
                     similar to SW:P07740 (LUXA_VIBHA) alkanal monooxygenase
                     alpha chain (EC 1.14.14.3) from Vibrio harveyi (355 aa)
                     fasta scores; opt: 215, z-score: 254.6, E(): 1e-06, 22.1%
                     identity in 272 aa overlap. Contains Pfam match to entry
                     PF00296 bac_luciferase, Bacterial luciferase."
                     /product="putative monooxygenase, mmyO"
                     /protein_id="CAC36766.1"
                     /sec_met_domain="mmyO (E-value: 2.9e-211, bitscore: 691.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYPETLGFGAFLSPMHPLGENPTLQFQRDLELIELLDRLDYNEFW
                     VGEHHSMGWNTIGSPELMVAAAAERTRRITLATGVMTLPYHHPFMVASRAVHLDHLTRG
                     RFVLGVGAGGIPTDARMIGREMSELRTMFGEALEAVVALVNGEERVTKKTSWFTLKDAK
                     LQLSPYRASGLEIAAASVASGNSMRLAGRYGISTVSFGAPRPGHPRPDMRTQWSYAEEA
                     AAEQGTTVDRRNWRITLPVYVAETREQALADVREGYDRWAYGYWGDIRGLDVSVPGVKR
                     AQALEAAVDAGSAIVGSVEDVVAGVERLREEVGGFGTLLVYAQDWADWEKTKRSYDLLA
                     RYVAPHFTGSTRRLYESVQWYQDNRDLFPQLIP"
     misc_feature    complement(13308..13619)
                     /gene="mmyO"
                     /gene_synonym="SCP1.240c"
                     /note="Pfam match to entry PF00296 bac_luciferase,
                     Bacterial luciferase, score 11.30, E-value 0.0048"
     regulatory      complement(13713..13718)
                     /regulatory_class="ribosome_binding_site"
     gene            complement(13737..14546)
                     /gene="mmyT"
                     /gene_synonym="SCP1.241c"
     CDS             complement(13737..14546)
                     /NRPS_PKS="Domain: Thioesterase (1-237). E-value: 7.1e-26.
                     Score: 83.9. Matches aSDomain:
                     nrpspksdomains_mmyT_Thioesterase.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36767"
                     /db_xref="EnsemblGenomes-Tr:CAC36767"
                     /db_xref="GOA:Q9ACS2"
                     /db_xref="InterPro:IPR001031"
                     /db_xref="InterPro:IPR012223"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:Q9ACS2"
                     /gene="mmyT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 141.6; E-value: 3.5e-43)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.241c"
                     /note="SCP1.241c, mmyT, possible thioesterase, len: 269aa;
                     previously sequenced and annotated as TR:Q9JN88
                     (EMBL:AJ276673) - note difference in predicted
                     translational start site. Similar to many others eg.
                     SW:P14686 (GRST_BACBR) gramicidin S biosynthesis GrsT
                     protein (EC 3.1.2.-) from Bacillus brevis (256 aa) fasta
                     scores; opt: 289, z-score: 338.3, E(): 2.2e-11, 29.7%
                     identity in 256 aa overlap. Contains Pfam match to entry
                     PF00975 Thioesterase, Thioesterase domain"
                     /product="putative thioesterase, MmyT"
                     /protein_id="CAC36767.1"
                     /transl_table=11
                     /translation="MRLFCFHHAGGQGTAFLGWQKRLGARAEVIPVRLPPPEDVSAETA
                     DGSGMSMTLVVASLDHELGPMLRRPFLFYGHSMGALVAYHLTRLRQSRGRPLPERLLIG
                     AYPAPHLPHRLAHCTHLPDEDLLALLPPHPAGHSRLLRQAPGLATATAARLRLHLGLCD
                     SAAPAAPNPAQHTGHGSPQGRSEPLRCPVDVFTGISDPLVTDAEAAAWRHHTRAGCRIH
                     RIPGGHFFTRETPESRAAFFDRLCTVLAGPSEWAAGASGPLPVTVAS"
     misc_feature    complement(13800..14546)
                     /gene="mmyT"
                     /gene_synonym="SCP1.241c"
                     /note="Pfam match to entry PF00975 Thioesterase,
                     Thioesterase domain, score 79.40, E-value 7.3e-20"
     aSDomain        complement(13836..14543)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mmyT_Thioesterase.1"
                     /evalue="7.10E-26"
                     /label="mmyT_Thioesterase.1"
                     /locus_tag="mmyT"
                     /protein_end="237"
                     /protein_start="1"
                     /score="83.9"
                     /tool="antismash"
                     /translation="RLFCFHHAGGQGTAFLGWQKRLGARAEVIPVRLPPPEDVSAETAD
                     GSGMSMTLVVASLDHELGPMLRRPFLFYGHSMGALVAYHLTRLRQSRGRPLPERLLIGA
                     YPAPHLPHRLAHCTHLPDEDLLALLPPHPAGHSRLLRQAPGLATATAARLRLHLGLCDS
                     AAPAAPNPAQHTGHGSPQGRSEPLRCPVDVFTGISDPLVTDAEAAAWRHHTRAGCRIHR
                     IPGGHFFTRETPES"
     CDS_motif       complement(14283..14342)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mmyT_0002"
                     /evalue="1.40E-05"
                     /label="NRPS-te1"
                     /locus_tag="mmyT"
                     /protein_end="88"
                     /protein_start="68"
                     /score="17.6"
                     /tool="antismash"
                     /translation="RPFLFYGHSMGALVAYHLTR"
     CDS_motif       complement(14514..14540)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mmyT_0001"
                     /evalue="4.40E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="mmyT"
                     /protein_end="11"
                     /protein_start="2"
                     /score="10.1"
                     /tool="antismash"
                     /translation="LFCFHHAGG"
     regulatory      complement(14561..14564)
                     /regulatory_class="ribosome_binding_site"
     gene            complement(14687..15331)
                     /gene="mmfR"
                     /gene_synonym="SCP1.242c"
     CDS             complement(14687..15331)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36768"
                     /db_xref="EnsemblGenomes-Tr:CAC36768"
                     /db_xref="GOA:Q7APH7"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR011075"
                     /db_xref="InterPro:IPR015893"
                     /db_xref="UniProtKB/TrEMBL:Q7APH7"
                     /gene="mmfR"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 93.8; E-value: 3e-28)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCP1.242c"
                     /note="SCP1.242c, mmfR, possible
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid-dependent
                     transcriptional regulator (TetR-family), len: 214aa;
                     previously sequenced and annotated as hypothetical protein
                     TR:Q9JN89 (EMBL:AJ276673). Similar to many
                     lactone-dependent transcriptional regulators eg.TR:Q54189
                     (EMBL:D49782) A-factor receptor from Streptomyces griseus
                     (276 aa) fasta scores; opt: 342, z-score: 422.0, E():
                     4.9e-16, 33.0% identity in 182 aa overlap. Contains Pfam
                     match to entry PF00440 tetR, Bacterial regulatory proteins,
                     tetR family and helix-turn-helix motif at residue 50-71
                     (Score 1532 (4.40 SD))."
                     /product="putative
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid-dependent
                     transcriptional regulator (TetR-family), MmfR"
                     /protein_id="CAC36768.1"
                     /transl_table=11
                     /translation="MTSAQQPTPFAVRSNVPRGPHPQQERSIKTRAQILEAASEIFASR
                     GYRGASVKDVAERVGMTKGAVYFHFPSKESLAIAVVEEHYARWPAAMEEIRIQGFTPLE
                     TVEEMLHRAAQAFRDDPVMQAGARLQSERAFIDAELPLPYVDWTHLLEVPLQDAREAGQ
                     LRAGVDPAAAARSLVAAFFGMQHVSDNLHQRADIMERWQELRELMFFALRA"
     misc_feature    complement(15092..15232)
                     /gene="mmfR"
                     /gene_synonym="SCP1.242c"
                     /note="Pfam match to entry PF00440 tetR, Bacterial
                     regulatory proteins, tetR family, score 76.30, E-value
                     6.5e-19"
     regulatory      complement(15338..15344)
                     /regulatory_class="ribosome_binding_site"
     regulatory      15509..15514
                     /regulatory_class="ribosome_binding_site"
     gene            15526..16587
                     /gene="mmfL"
                     /gene_synonym="SCP1.243"
     CDS             15526..16587
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36769"
                     /db_xref="EnsemblGenomes-Tr:CAC36769"
                     /db_xref="GOA:Q7APH6"
                     /db_xref="InterPro:IPR005509"
                     /db_xref="UniProtKB/TrEMBL:Q7APH6"
                     /gene="mmfL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCP1.243"
                     /note="SCP1.243, mmfL,
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid biosynthesis
                     protein, len: 353aa; previously sequenced and annotated as
                     hypothetical protein TR:Q9JN90 (EMBL:AJ276673). Similar to
                     many others eg. TR:O86851 (EMBL:AJ007731) ScbA
                     gamma-butyrolactone biosynthesis protein from Streptomyces
                     coelicolor (314 aa) fasta scores; opt: 336, z-score: 389.2,
                     E(): 3.3e-14, 28.7% identity in 310 aa overlap. Contains a
                     TTA encoded leucine at residue 8, possible target for bldA
                     regulation."
                     /product="2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid
                     biosynthesis protein, MmfL"
                     /protein_id="CAC36769.1"
                     /sec_met_domain="AfsA (E-value: 2.4e-25, bitscore: 79.0,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHTNRLLLPAPHDLLFDGCPPLSFARPLPPADVHKAAAAEVLLT
                     DARPLGENRFAVAALWPRNTFLAHRATSSPCDPLLAAETIRQSAIHLSHTFCDVPIGHH
                     FVLSGLDLDLDLPVWDSGPLPVVLDVTSTKTTTNPRRMARALNADVYVAGLHRGRCAIR
                     FEVLAPRRYAMIRDRARRAERPAQQAAAGAATALPPETVGFHDDLHVLLATAQGLPDTA
                     WQLRLRRDHPVLFDHESDHISGMALLEACRQAATALTPPAPGAFGPRQVALTAVASSYQ
                     AFGELDSPVTITTLPAAHGHSPDSGTRTLQLTARQGSRTLITATVTTTTTAGTGSPGPT
                     VPHHGDQTKAVAS"
     misc_feature    15547..15549
                     /gene="mmfL"
                     /gene_synonym="SCP1.243"
                     /note="tta leucine codon, possible target for bldA
                     regulation."
     misc_feature    15547..15549
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     regulatory      16575..16579
                     /gene="mmfL"
                     /gene_synonym="SCP1.243"
                     /regulatory_class="ribosome_binding_site"
     gene            16584..17786
                     /gene="mmfH"
                     /gene_synonym="SCP1.244"
     CDS             16584..17786
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36770"
                     /db_xref="EnsemblGenomes-Tr:CAC36770"
                     /db_xref="GOA:Q7APH5"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013107"
                     /db_xref="InterPro:IPR013786"
                     /db_xref="UniProtKB/TrEMBL:Q7APH5"
                     /gene="mmfH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 327.8;
                     E-value: 1.2e-99)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCP1.244"
                     /note="SCP1.244, mmfH, possible oxidoreductase involvedin
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid
                     biosynthesis, len: 400aa; previously sequenced and
                     annotated as hypothetical protein TR:Q9JN91
                     (EMBL:AJ276673). similar to many possible oxidoreductases
                     eg. TR:O68921 (EMBL:AF058302) putative enoyl reductase,
                     FrnT from polyketide antibiotic frenolicin biosynthetic
                     cluster of Streptomyces roseofulvus (396 aa) fasta scores;
                     opt: 867, z-score: 921.4, E(): 0, 48.0% identity in 329 aa
                     overlap."
                     /product="putative oxidoreductase involved in
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid
                     biosynthesis, MmfH"
                     /protein_id="CAC36770.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.3e-09, bitscore:
                     27.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPLREFSRDGVEHAVALAHRDHGVQETHRRLTDDVARAVTDVG
                     FPRHFVPRRFGGRAGTFGELLTAATTLARTCAATAWCATLYAAHGRLASYLPEKAQREL
                     WHSSPDARIAAAIMPPSGEANLEPGGWRLTGRWGFASGVDHADWVLLASWTPGRNVPER
                     HRLFAVPRDELTVTDTWHTLGMRGTGSNTVEADGVLVPRHRTCTLSDLLLPLPGSARCH
                     TVPYAMVGALMFAFPVLGAARGALDAWTHAATERQGTAVPPASNTLTRAAARIRAAGLL
                     LEAAAERADHAPVTPLLVAEGQRDAAAAVELCSEAVDQLLRASGSRGQAEDDPVQRHWR
                     DITTAATHRALSIDAAAGAYTPALFDRADPSTGVGPAEPGGPAGPPGRTATAPDTERRT
                     A"
     gene            17783..18580
                     /gene="mmfP"
                     /gene_synonym="SCP1.245"
     CDS             17783..18580
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36771"
                     /db_xref="EnsemblGenomes-Tr:CAC36771"
                     /db_xref="GOA:Q7APH4"
                     /db_xref="InterPro:IPR006383"
                     /db_xref="InterPro:IPR006385"
                     /db_xref="InterPro:IPR023214"
                     /db_xref="UniProtKB/TrEMBL:Q7APH4"
                     /gene="mmfP"
                     /gene_synonym="SCP1.245"
                     /note="SCP1.245, mmfP, putative phosphatase involved in
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid
                     biosynthesis, len: 265aa; previously sequenced and
                     annotated as TR:Q9JN92 (EMBL:AJ276673). Similar to
                     SW:O33611 (IMD_STRCN) inhibition of morphological
                     differentiation protein from Streptomyces cyaneus
                     (Streptomyces curacoi) (277 aa) fasta scores; opt: 329,
                     z-score: 384.0, E(): 6.4e-14, 32.0% identity in 225 aa
                     overlap. Also similar to neighbouring CDS SCP1.235 mmyP
                     (previously sequenced as TR:Q9JN84 (EMBL:AJ276673)) fasta
                     scores; opt: 453, z-score:556.3, E(): 1.6e-23, 38.9%
                     identity in 234 aa overlap."
                     /product="putative phosphatase involved in
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid
                     biosynthesis, MmfP"
                     /protein_id="CAC36771.1"
                     /transl_table=11
                     /translation="MMPEPPRERRTAANRSPAIRPIAFFDVDETLITAKSMLDFARQAP
                     HSLRDDITAQASGQRHSADADLTAMRRRGASRVEMNRVYYRRYAGVSLARLQEAGRDWY
                     HAYRTRPDGYVRAGLAALARHRRAGHTIVLISGSARPLLTPLAQDLGADRILCTEQFAD
                     AQGVLTGEVNRPMIGEAKAEAVTEVMAKRGVVPADCFAYGDHESDFGMLQAVGNPVVVG
                     TDLVLVRHAQGSNWPVLPADAGPRCACARRPGPLGHDDPSAIG"
     gene            18731..19342
                     /gene="mmyR"
                     /gene_synonym="SCP1.246"
     CDS             18731..19342
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CAC36772"
                     /db_xref="EnsemblGenomes-Tr:CAC36772"
                     /db_xref="GOA:Q7APH3"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR011075"
                     /db_xref="InterPro:IPR015893"
                     /db_xref="UniProtKB/TrEMBL:Q7APH3"
                     /gene="mmyR"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 93.6; E-value: 3.4e-28)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCP1.246"
                     /note="SCP1.246, mmyR, possible
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid-dependent
                     transcriptional regulator (TetR-family), len: 203aa;
                     previously sequenced and annotated as hypothetical protein
                     TR:Q9JN93 (EMBL:AJ276673). Weakly similar to many
                     lactone-dependent transcriptional regulators eg. CprS
                     protein from Streptomyces coelicolor (215 aa) fasta scores;
                     opt: 240, z-score: 299.2, E(): 3.3e-09, 26.9% identity in
                     193 aa overlap. Contains Pfam match to entry PF00440 tetR,
                     Bacterial regulatory proteins, tetR family and
                     helix-turn-helix motif at residue 29-50 (Score 1129 (3.03
                     SD))."
                     /product="putative
                     2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid-dependent
                     transcriptional regulator (TetR-family), MmyR"
                     /protein_id="CAC36772.1"
                     /transl_table=11
                     /translation="MKQARAMRTRDQVLDAAAEEFALHGYAGTNLATVAVRTGMTKGAL
                     YGHFPSKKALADELVSQSTETWNTIGRSIAETACAPETALRALVLAVSRQMKHDIRFRA
                     ALRLAADCTMPAGGAPDLLDRIRREMAAAARDTQQQQAPYSPLATQPPDVVVHLLLTVA
                     YGLSFAAERGAPGRSPATTDKVWELLLTALQLEDISTCHN"
     misc_feature    18767..18907
                     /gene="mmyR"
                     /gene_synonym="SCP1.246"
                     /note="Pfam match to entry PF00440 tetR, Bacterial
                     regulatory proteins, tetR family, score 63.30, E-value
                     5.4e-15"
ORIGIN
        1 tcatgcggcg ccgacccgtg cgtaccgacc ctgaaagaag agcagcgggc tctccgtgtt
       61 cgtcgaaaga gccaggtcgc gcacacggcc caggacgaac cagtgatccc cggcgtcggt
      121 gaccgtatcg atgtcgcact cgatccaggc gatgacgtcg tggagggcag gtgcgccgtt
      181 ggaggcacgg cgccagggga tgccggtgaa tttgtcgccg ccactggtgg cgaaggcgcg
      241 gcagacgtcc tgctggtggt cgccgaggac attcaccacg aaggagccgg cacgttggac
      301 gagtggccag ctggtcgagg acttgccggg gaagaagccg accatgggcg gatcgaggga
      361 cacggaagcg aaggacccca cggctaggcc ggccggctcg ccgtcggcca tggcggtgat
      421 cacgaccact ccggtgggga agtggcccag gacccggcgg aaatgggcgg agtcgatcgt
      481 cgcgagcggc ggcttggcgg ttgccgtggt cacatccgta gccatgcgga ctccctggag
      541 gagaagggga aacagtcagc catcctggag ggccaggtcc ctgatgtggc ggttcccgtc
      601 ggcccagagg atgttcatgg tcagcgcgct gatgcgccag ccgtctgccg tgcgcactag
      661 gccgtagcgg tactcgccgc ccagagtcca ggtcgggcca ccgaaggggt tgggcagcag
      721 gtgggtggcc tggaacatcg cggtggtgtg agcggtggct ccgtcgacgg tgaccaggtg
      781 gttggagagc aagtgctgtg tggcttgcag gccttcacgg ttgctgcgcc acttgccgat
      841 gacgtccttg cgcggaagcg tcaccggctc cccgccgttg aggctggtgt agtccagccg
      901 gatctcgtcg gtgaacaggt cgacgagctg gtcccattcg cagtggtcca ggtgccacgc
      961 catgcgggtg cacagctcaa tgatcgcgta gcggtcacgg agttgctgat cggtcacggt
     1021 gaactccttc ggcgagtggt tcggatcgct ggcgagtatc ggcagggtcg tgcgaaggct
     1081 gccagagcga acttctgcta ggggcctcag acgtggtgtt ctcagcacca gggccccgcc
     1141 gagttgcggt ccaaacaccg aggccccgcc gctctcgtaa gccccggttt aactctccgt
     1201 tacgagtcat aaaaaacctt cgggaaggtt tgacactgtg aggcgccatg gctagcgtcg
     1261 atggcgtggc caaagattcg acggtgtgca gtcctaaaag gcagcgcgag gcgttacgcc
     1321 acttcctgcg gtcccgcaga gcacggcttt cacccgacga cgtcgggttg cttgctaccg
     1381 gtcggcggca cacgccggga ctgcgccgtg aggaagtcgc agtcatcgcc ggagtcagcg
     1441 cctcctggta cacgtggctc gagcagggga gggatatcaa agtctcggac ggcgtgctga
     1501 acgcgatcag tcaggccctg agactcgatg acaccgaacg ggcacacctc taccggctgg
     1561 ctggggtcaa tccgccgcag tcggtgccgg cgaccgcggg gcagacagag acgtccagac
     1621 ttcagctcat cgtggacggc tggctgccgg cacccgcttt cgtcgtcgac cgctactgga
     1681 acaccctggc cgccaatcag gcggcacggt ctgcgctggg cgtgggagcg ggcgaccaga
     1741 actacctcgc ggcgttcttc accgagccga ccgcccgcgc ccgctacctc gactgggaca
     1801 agctggcgac ccggttggtc ggccagttcc gtgtccaggc agcacgcttt ccggaagatc
     1861 cgcggttcga caggatcgct cgccagctgt gcgccaccga ccatgccttc gccgacctgt
     1921 gggccaggca cgaaacctgt gacacggcga tgacgagtgt gcgggtacga ccgccgggcg
     1981 aggagagcat gcgcttcgag cacctgatcc tggcgcttct cgagaacgcg gatctacggc
     2041 tcatgctcta catgcccagg ggcgcgcaca tctccgcaga ggccggtctg cggctggtgc
     2101 cagctgaccc cctgacgcga aattccctac tccaactccc tggtcgtccg atgacgtcac
     2161 gacctgtcga gcggcacatc catccctgat cccgtgggcc tgcgcggctg cagcaacagg
     2221 caaacgcgtg tgcatacctg cggaaagcca ggaagtatcc caaggagttc tccccatgac
     2281 caacaccagt acgtcactgc gcatcggtgt ccttggtgca ggcaatatcg gtcgccccat
     2341 cgggcggcac tgggcagtgg ccggtcacga ggtggcgttc gggtcgcgca cccccgatca
     2401 gctcacggag ttcgcaggcg ccctccgccc ggccgcgcgg gccacgacac tggccgaggc
     2461 cgtggagacg agcgatgtcc tcctgctgtc ggtgccctac tccgcctggg acgacctcct
     2521 gcaggcggtc ggtgaccggc tggccggcaa gctcgtcatc gacgccacca accccatggg
     2581 cctgtccgag gaaggccgca tcatctccac cctcgaccag ggcatcactc aaggccgaaa
     2641 ctccgcgaag ctgctgccgg aggccacggt ggtacgggcg ttcacgcaca tcatggacga
     2701 actcctgtgg tcgcgcggca cacagcagaa acacttctgg gggatggcgt acgccggtga
     2761 cgacgtcgat gcgaaggagg tcgtcgcccg cctgatccac gacgcgggat tcagccccgt
     2821 cgatctggga gggcttgacg actccgccgc actcgacccg ggcggtgcca tcttccccca
     2881 catgttcact ccggccgacc tgcgcgctgc ggcgggcctc agcgcgtgag caggcgaggg
     2941 ccgtccggca accgtgccgg acggcccccc accgggaacc agtcatccga agggacagat
     3001 gcacgtgccc agcacagctc cgcctcctgc cacggcagcg ccactgttcg ggcccttcac
     3061 cgtgggttca ctggcgctgg agaaccggat cgtcatggcg ccgatgacac gagagctctc
     3121 ccctggagga gtacccgggc ccgaggtggc tgcgtactac gcgcgccgcg cccgaaacgg
     3181 cgtgggtctg atcatcaccg agggagcggc catcgggcac ccctcttccg agcgtcgtgc
     3241 cgcagttccc cggatccaca gtgctgacgc gctggccgga tggacgagag tgacccaggc
     3301 agtccatgcg gccggcggcc ggatcgcggc ccaactcatg cacgtgggac tggatccgct
     3361 gttgtggggg atgactcccg cggagatgga cgccgcctca ccggccgggt tcgagctgct
     3421 cagtccgtcg ggcgtcgatc catcacagcc cgcggcggcc accgtggggc gcgagatgag
     3481 cgacgtggac atctcgagtg tgatcgaggc ctatgctcgt gctgcagcgg aggcccggca
     3541 ggccgggttc gacgcaatcg agttgcacgc cgctcacggc tacctcatcg accagttctt
     3601 ctgggcggtc accaatcggc gcaaagaccg ctacggcggg gatctgtcgg cccgcacgcg
     3661 tttcggcgcc gatgtcgtgc gggcctgccg gcacgcagtg ggagaggact tcccgatctt
     3721 cctgcgattc tcgcagtgga aggtcggcca ctacgcagcg cggctcgccg acagtccgga
     3781 cgagcttgca gccgtgctcg gcccgctggt gcaggcgggg gtggacgcct tccactgctc
     3841 gacgcgccgg ttctggcagc ccgaattcga gggatcggac ctcaatctgg cgggctggac
     3901 gaagaaggtg acgggccggc ctgtcatcgc ggtcggctcg gtcgggctga aggacagcga
     3961 cttcctctcc tatcttgacg gcaagggagc cgatgtcgga gatgtgagtg tggtggccga
     4021 caggctcgca cagggcgagt tcgatctcgt cgctgtgggg cgtgccctga tcgccgatcc
     4081 cgcgtggccc gccaaggtgc ggggcgggcg ctcggccgac ttgattccct tcgacgcgcg
     4141 catgctcacc agcctgcact gacgccgtgc agggcggtga caccacggcc cgggtccgct
     4201 cctcacgggg gcgggcccgg gccacgcgct gagggagcgt gcagggccgt tgggtgtcgc
     4261 ccgctcatgc ttctggccgg cctcggccag cggcaacccg tatccgccac cggcgcgagc
     4321 cgcccccacc gtccaactcg gtgaggcaag cgaccatcgc agcacggatg gcgaacgtcc
     4381 atgaccacgt catccgtgcc gagagccacc agtcggccgt gccggcccac aggcggtctc
     4441 tgccaccttc gccccgaggg ctttgccgac ctgcaccgcg agatggccga caccaccagc
     4501 ggcgccgtgc accaggacgt gctgctctga cgcagctccg cgcggtccgt tccggaaacc
     4561 catacgcgaa aagcgttgtc acgcccgctc cagggcggaa cagaccggcg ctcctggtgt
     4621 ccccaccacc accaggggcc gtaccagcag aatttcgctc tggaaatccg tccggcaatg
     4681 acgaaatagt ggcatcacat cgattgcacc tgtcgggaaa aaactggagg gtgcatgcca
     4741 gtcagcggtt ccctatcgca gaaactgttc catcgctctg tcgacgacgt tctgggcccc
     4801 cgcgaaagac gattcttcgg tgagggcttc aaacgggccg agcatcgctt gcggcacatc
     4861 tttgtcacct acgggcccga gggaagggcg caggccgatg cccgcgtcag cgtggactat
     4921 ccctcggact ggtcacgcaa gggcgacgca gaccaacgcc ctcacctgtc cacggtcgac
     4981 gtcctggtga tcggcgctca gctcagcgaa gtgcacctgg cgcatgtcct cgggctgagc
     5041 ccggaccagc gcgcgcgggc cgtgcttcag cgggtccgta tcaaagccgg gaggtctccg
     5101 gtcgaggagg acctggccgg gttcgcggcc agcgcccagt tggtggcgac catcccctcc
     5161 gaccgggtgg tcggcctctt cctcagcacc gtggaatgcg tggtcggcac tctgcggatg
     5221 cggtgtgaga tccgccatga ggcgggcgtt ccccaccagg ccgccggctc ctacgactcg
     5281 ctgcgtggcc tgctcggtga cccgcgcctg cggctgttcg gcgagggctt caccagccgc
     5341 aggcagctcg tcgaggatgt cgtgatcgac ccgcaggctc ggcaggccgc cgccgccgtg
     5401 cgcgtaatca gggacgagga cgctccctcg cccgcgaccg gactcgaagg cgcgcaccac
     5461 gaccgcgcgt ccgcgatcga cgcgttcgtc atcgggctgc aactgggcca agtactgctc
     5521 tacacgctcg atgaagtgcc acgggcccag agcaacacgc tgtggatgcg cgaaacgatc
     5581 ctcgaactcg atccgctgcg gccgccactg cctgcgaccg cgcccgtgac cacgcggctc
     5641 gaccgctgca agcggctcga aaccggtaag ggggacatct ggcggtcggc ggacatcgtc
     5701 ggcgagttcc tgggtgtgcg gctgcgctgc tcggtcgccc accgcctgcc ttgacccact
     5761 gtccaccgtc ggcctgccct gcaggacacg tggccctcac caaccaccac tcctcattcc
     5821 attggatccc ccgggatccg cagactcgaa gaaagcagaa ctcctatgaa cctggccatt
     5881 tctggtacgt actcggtggg aaagaccctg accaccatgg ccgtctccca tctgaccgga
     5941 cttccgcgca gtgccgcgaa gacgatgcgt gaattgctgc cgatctccgt gcccgggaaa
     6001 accctcgaag agtgcacggc atccgagatc atcatgctga tcatgcggcg caaccaggag
     6061 cgcgcggtca acgagagcca cctgccccga ggtttcgtct ccgacggatc ctcgctccac
     6121 gagtggtgct acggcaccgt ccgcgtcctg gtgggcatca acccgaacga ctcggtgaac
     6181 ctcgagaacg tcgagatgac ggacgacatc cggttcttct cccaggtcat ggaccagatg
     6241 ggcgtccccg ccaagcagca cgccaaggcc tcgtacaact ccttcgtcca tctgcccatc
     6301 gagttcccgc tggtcgagga cggccaccgg cccgtcaacg agcgcttccg ctcgctggcg
     6361 gacgagatgc tgctgaaggt cctcgacgaa ctgcagatcc cggtgcacat agtcggcggc
     6421 acaatcccgg aacggctgca gaagatcatg gacatctacg acttcacacc gcagatgtcc
     6481 atcgacgaag ccatcacccg ggcccaggag gactacgcga agatcgacac gaccagcgag
     6541 accgaccgtg cgccggtcgc ggcggcatga gcggcgcggg cgttctcgcc gggctgggga
     6601 ccgctctgcc ggcgcggctg gttaccaacg aggagctgtc ccggcacctg gacacggacg
     6661 acgagtggat ccggtctcgg accggcatcg ggcagcgcta ctggagtgac ggcgcgtcca
     6721 cgggtgacct ggccgtcgag gcgggacagc gtgcgctgaa ggctgcggga acggacacgg
     6781 tggacctggt ggtgctggcc accaccacac ccgaccaccc gtgccccgcc acggctccgg
     6841 acgtcgcgga ccgactgggc ctgagcggtg tcgcggccta cgacatcgct gcggtgtgca
     6901 gcggtttcat ctacggactc gcctctgcgg tcgcgcacat caccgccggc ctcgtgggca
     6961 gcgccctggt catcggtgcc gagacgtatt ccaccatcct cgatccgctg gaccggacca
     7021 cgtccgtcat cttcggcgac ggcgccggtg cggtcgtact gcggtcgggg tccgtcgacg
     7081 agaggggagc gttcctcggg ttcgacctcg gcagcgacgg ggcgctgaag gacctgatcg
     7141 tgataccggg cggcggatca cgcgagcggg ccgcggcgga gcgcccgcag ccggccgggg
     7201 cctacttcac catgcagggc aagccggtgt tccggcacgc ggtgacgagg atgacttcat
     7261 cggccggcgc gctgctcgac cgtaccggct ggtcgccggc gtccgtcgac cggttcgtgg
     7321 ggcaccaggc gaacgcgcgg atcctgcatg ccgtcgccga tcagctccgc atcgacggcg
     7381 cacgcaccgt gatcgatctc gaccgagtcg gcaacacctc agcggcctcc atccccctgg
     7441 cgctgtcgcg agcctgcgga gaggggctgc tgtcgccggg tgaccgggtc ctgctcagcg
     7501 cgttcggcgg cggactgacc tggggatcca cggcactgct gtggcccgac atcaccgccc
     7561 tgtgaggtcc gcgcagccca tccgagcaac ggccggatca ctcaccccct gatgcgaagg
     7621 agaacggcat gaccgagtcc acggtcgcgc gcatcatcgc gatcatctgc gaacacttcg
     7681 acaccggtga caccgaggtg tcggcggcca ccgacttcga gtccttggag ttcgactcgc
     7741 tggtcctcgt ggaactggcc gtcatcctca cccgtgagtt cggtgtcgag gtgaccgacg
     7801 acgaactcgc cgacggcagg accatcggcg aagccgcagc cgtcgtggcc cgcaagagca
     7861 ccgctctggc ccggtgagcc cgcggcggtc ccacgtctcc cgcaaggagc gatgaccgac
     7921 ccgggtgggg agggtgccgg tggtgccctc cccacccggg tcttccttct accgaccact
     7981 tcccgccaga caggagagac gtgcccgacg tcccacgctc cgcggccttc ttcgacatcg
     8041 acggaacgct gacggccacc accaccatgt tcgacttcct cgcccaccat ctgtccctcc
     8101 acggcagacc ttccgagtac gccgcactgc acggccggct gcgcgccatg acggaggccg
     8161 gtgcgggccg tgccgaccgg tgccgtgcct actaccgcgt gtatgcgggg gtggaggagc
     8221 gaggtctcct cgccgaaggc gaacgatggt tcctcgaccg ggtccggaca cccggcttct
     8281 tccacgagcc cgcacgtgcc gcgttcgacg cccacgctgc cgcgggcgat ctgaccgtcc
     8341 tcgtatcggg ttcgttcgac gcctgcctgg aaccgctcgc cgagcacctc ggtgccgacg
     8401 tactgctgtg ctcgcgcccc gaggtgcacg acggccgcta cacaggcgcc ctcacgacac
     8461 cgatgatcgg cgcggccaag gcagctgcgg tgtccgctct cgtcgccgag cgctcactgt
     8521 ctctgaagga ctcccacgcg tacggggacc acgtgtccga cgttccgttc atggagctcg
     8581 tcggccatcc ggtcgtcgtc ggtcgtgacc cccgaatgcg ctgccatgcc cgcgcacacg
     8641 gctggcggtg cctggaggac tccccgttgc cggggacggc aggggggagc aggtcatgac
     8701 tctcaaccgc cccatgcgga tcgccgtcgt gggcgcgtac ggcaacggca agacaactct
     8761 caccaccgaa ctgtcccggc ggctcggact cccgcgcacc cacggcgcgg ccatgcgcga
     8821 cccggcgggc ggatcgggca agtccttgga ggagtgcaca gacccggagc tgatccagct
     8881 cgccgtccgg cggttcaccg aacgagtggt ggacgaggcc cgctgctcac gcggattcgt
     8941 ctccgacgga tcggtcctgc acgagtggat ctacacgaag gtgcgtctgg tgctcggccg
     9001 cctgcccggt ccctctgccc ggctcgaacc cgtcatacgg tcggccgcga ccgcggcgta
     9061 cgaagaagtc atcgaccaga tcggcctgct gacccagcag cacgctttcg acacgtacga
     9121 cctggtggtg cacctgcagg ccgacgtgcc tctgccggaa ggccaccgtc cgatcagcga
     9181 gcacttccgt cgcgtgtccg accaactcct gcgggacacc ctggaggcgt ggcgcatccc
     9241 gtgccacgtt gtcactggca gtgtccagga gcgggtccgc cggtgccggg aactggtcga
     9301 tacccggagt gcgtgagcag ggacagaagc aggggccccg accgtgtcgg ggcccctgca
     9361 cgggttgcgg gcgtgcggtc aggtggccgc cgtgacggcg ctgcggcgtt cggggcgggc
     9421 gatgagccgc caggcgctga ggccgccgag gaggtaggcg aggccgacgg cgaggaagga
     9481 gatcgcggcg ccgtggtccc agtcgctggt ggagtgcagg accacgccca tggccgcgat
     9541 gccgacgagt gagccgatct gccggttggc gttgaggacc gagccggcca cgttggcgtt
     9601 ctccggtccg gcggcgtcca ccagggcggc ggtcatgccg ggggagatga tgccggcccc
     9661 gatgttggcg acgccgaccg ccacggccac gacccagtag ggggtggacg ccgtgatggt
     9721 gaccatggac agggaggcgg cgccggcgag gagcaggaag gcggtcagca gggtgccgtt
     9781 ggagaaccgt gcggagatgc gtgcgtagac gatgttggcc accgggaaga agatcgtcat
     9841 gggcagcagt tcgagcccgg cctggaaggg ggtggctccg cgggcgtgct ggaagtacag
     9901 gccgagcatg aaggtcgacc cgaacagtgc gaagttgaac aggaagccga cgaggttggc
     9961 tcccgtgaat ccagggccgc ggaacagctg ccagggcatg accgggttgg tgacacggtg
    10021 ctcgcggagg gcgagcagcg cggcggcggt caccgccacc gcgtaggcgg tgagcaccgg
    10081 gcctgcggtc cagcccagtt gcggcccttc gatcagggcg aagctcacgg cggccagtgc
    10141 gacgatccag agcaggtggc cgggaacggc gaggcgggtg gcgcggcttt ccgtggcggc
    10201 gatgtagcgg taggtcatgg ccatgccgat ggcgccgatc ggcaggttga gcaggaagat
    10261 ggattcccag ccgaaggcgc tgaccatgag cccgccgacg gtcggtccca ggcctgacga
    10321 ggtggcgacg atcgccgacc acagtcccag catgcgggtg cgctgccgct tctccgggaa
    10381 ggagaagacc agcagggaca gggaactggg catgaagagg gccgcgcccg cgccctggac
    10441 gagccgggcg gcgatcagag tttcggcggt gggagccagg gcgcaggcca gggaggcgag
    10501 gaagaagacg cccatgcccc acaggtagac ggtcttcgcg ccgatccggt tggccagtcc
    10561 gcccgcgagc atcagcagtg aggcgaaggt caggacgtat ccgtcgacga tccaggtcag
    10621 ctgggtcagc gtggtgtcca ggctctcctg gatggtggct ccggcgacgt tcaccacggt
    10681 gacgtccagg gtcgccatga cgaatcccgt ggccagagcg gtgatcttca ccccgctggg
    10741 gacatcgcgc cggccgcccg ccgggacttc ggcggtctgc gccccgcctg ttcggacagt
    10801 ggtcatgctg ttctgctcct gtgggggtcg ggtatgggcc gcgtcctgag gagtggccgg
    10861 cagagggcgg ccggggggga tggcggccgc ccaactgcgc cggaattacc gtgcgttctc
    10921 actgaagctc atatgacgac ggctgtcaaa ctttgatggc cgtcaacatt tgatggctgt
    10981 cgtaccatgg tggaacgaca cgcgacgagg aggcggacag ccgtggcggc acggatcacg
    11041 acagagcgca tcaccgacca tccggacgct gacgccatca ccctccaggg cgtcctggac
    11101 gcgctggtcg atccggtgcg ccgcagcatc gtccggcagc tggctaaggc acccgaggac
    11161 atcgcctgcg gcaccttcga catcaccgtc tcccgctcga ccggcactca ccacttcaag
    11221 gtgttgcgcc aggccgggat catcaggcag tactacatcg gcacctcgaa gatgaacacg
    11281 cttcgcaccg atgatctcga tcaggccttc cccggcctgc tcaccgcgat cgtcgacgcc
    11341 gcggccaggg agagctgacc ggccaccgct cgcccgcacg gcgctccagc cggcagccgg
    11401 ttgcggagga cagccgtacg gcgtccagca gccggtgcag ctcgatcccg tcggcgaaac
    11461 gaggcacacg actgccgccc tcgcggatgt ccgcggccag agccgcgtac tgcacagcca
    11521 tggtgtgctg ggccgcatcg agaccgtccg ctggcacggc cgtgccccag gagccgggaa
    11581 agggcagctc ctgcccggac ggctctgtcc cctgcgctcc gagcagggcc agttcgctga
    11641 tctgcagccc gctgccgctt cgtggtccgg tggatacgat ggccagctcc ccttgcgtgc
    11701 cggagatctc gatgcgggtg cccgcgccgc tgttcttggc atcgtggatg tggaccacca
    11761 gcgcggcgcc gccttccagc gtcgcgtgca gcgcgacatg atcggggctg gtcgcccccg
    11821 tctgccgggc gtcctcgtcg agtgtgatcc gcggatgctg aacggacagc gcagccgaca
    11881 ggccggtcat ctccctgccg agcaggtact gcaccgcgtc gagcgtgtgc ccgccggcga
    11941 cctcgagggt gccggcgccg ttcgtggagt cgagggtgta ggcgaaggcg gcgggcagcc
    12001 gccccccggc cgcgaccccc cgcgtgctgt acacggtgac cgaggtgacc cggccgacgt
    12061 acccctgcct gatcagttcc cgggcccgga cgaccgtcgg ggtgtgccgc gcctggaggc
    12121 cgacggcgtt caccacaccg gctccgtgag cggccgccgt tagctgggcg gcctcctcgg
    12181 tggtccgggc aaggggccac tcgcacagga catgcttgcc cgccgcgagc gccgcctcca
    12241 ccagccgcgc atggtccggc actttcacga cgatcgcgac cagttccacg tcgggatgtg
    12301 cggcgaggct gcgggggtcg gtgaaggcgt gggtcgcccc gtaccggcga gcggcccggt
    12361 gcgcactgtc cgcccggcgg gtgccgaccg cggtgatctt gtactgcggc aggtgctgca
    12421 gggccggcag gtgtgcgtcg gcggcccagc cccggtccgg ggaggcgccg accacgccga
    12481 tgcgtatcgg ttcggtggcc atggggtgtc gctgtcactc cagggaggga tgccgagccg
    12541 tgcctggagc tgcccgtggc gccggcaggc acggcgtgca cggtttacgg gatgagctgc
    12601 ggaaacaggt cgcggttgtc ctggtaccac tgcaccgact cgtacagtcg ccgggtggag
    12661 ccggtgaagt gcggggcgac gtagcgggcc agcaggtcat agctccgctt cgtcttctcc
    12721 cagtcggccc agtcctgcgc gtagacgagc agggtcccga agccgccgac ctcctcacgg
    12781 agccgctcga cgccggccac cacgtcctcg acggagccga cgatggcgct gcccgcgtcc
    12841 acggcagcct ccagagcctg cgcacgcttg acgccgggga cgctgacgtc gaggccgcgg
    12901 atgtcgcccc agtatccgta ggcccagcgg tcgtaaccct cccggacatc ggcaagggcc
    12961 tgctcgcgcg tctctgccac gtataccggc agggtgattc gccagttcct gcggtccacc
    13021 gtggtgccct gttcggccgc agcctcctcc gcatacgacc actgggtacg catgtcgggt
    13081 cggggatgac caggccgcgg cgcaccgaag gagacggtgc tgatcccgta gcggccggcc
    13141 agccgcatgc tgttgccgga ggcgacgctg gcagcggcga tctccagccc tgatgcacgg
    13201 tacggggaca gctggagctt ggcgtccttc agcgtgaacc acgaggtctt cttggtcacc
    13261 cgctcctcgc cgttgaccag cgcgacgacc gcctccagtg cctcgccgaa catggtgcgc
    13321 agttcgctca tctcacggcc gatcatgcgg gcgtcggtcg ggatgccgcc cgcgcccaca
    13381 ccgagcacga accggccacg ggtcagatgg tcgaggtgca ccgcacggct cgccaccatg
    13441 aacgggtggt ggtacggcag cgtcatcaca ccggtggcca gggtgatacg acgggtccgc
    13501 tcggcggcag ccgcaaccat cagctccggg ctgccgatgg tgttccagcc catggagtga
    13561 tgctcgccga cccagaattc gttgtagtcg agccggtcga ggagttctat cagctcaagg
    13621 tcgcgctgaa attgcagcgt gggattctcg cccagcggat gcatggggga gaggaaagca
    13681 ccgaatccga gcgtctcggg gtacatgaac gtcctcctgg gttgcgggaa acgcttttac
    13741 gaagcgacgg tgacagggag gggacccgat gctccggccg cccattccga cggccctgca
    13801 agcaccgtgc acagccggtc gaagaacgcg gccctagatt ccggggtctc gcgcgtgaag
    13861 aaatgcccgc cggggatgcg gtgtatacgg cagcctgcgc gggtgtggtg ccgccatgcg
    13921 gctgcctcgg cgtccgtcac cagcggatcg ctgatcccgg tgaacacatc caccggacac
    13981 ctcagcggtt cactcctccc ctgcggggaa ccgtggccgg tgtgctgcgc ggggttcggt
    14041 gccgccggcg cggcgctgtc acacaggccg aggtgcaggc gcagccgcgc cgcagtcgct
    14101 gtcgccaggc cgggcgcctg gcgcagcagg cgagagtggc cggcagggtg cggcggcagc
    14161 agcgcgagca ggtcctcgtc aggcaagtgc gtgcagtggg cgagccggtg cggcagatgg
    14221 ggggccgggt aggcgccgat gagcaaccgc tccggcaggg gccggccgcg ggactggcgc
    14281 aggcgggtga ggtggtaggc cacgagagcg cccatgctgt gcccgtagaa caggaagggc
    14341 cgccgcagca ttgggccgag ttcgtgatcg agggaagcga ctacgagggt catcgacatt
    14401 ccgctcccgt ccgctgtctc tgcagagacg tcctcgggcg ggggcagccg gacgggaatc
    14461 acctccgccc gcgctcccag tctcttctgc catccgagga atgctgttcc ctggcctcct
    14521 gcatgatgaa aacagaacag acgcaacgct gcggccgggg ctcccgtccg cgcgctggtc
    14581 gtcgcggtgt ccgcaatcat gcagagaacg taatcggtgc tggagcgcag ggaaaagagg
    14641 gagattctcc tatcagtggc accaccagtt ttgcggacgc tccccgtcag gcgcggagag
    14701 cgaagaacat cagctcccgc agctcctgcc accgctccat gatgtccgct cgctggtgca
    14761 gattgtcgga gacgtgctgc atgccgaaga aggcggccac cagggaacgg gcagctgctg
    14821 cgggatcgac gcccgcccgc aactggccgg cctcacgggc gtcctgcaac ggcacctcca
    14881 gcaggtgggt ccagtccacg tagggcaggg gcagctccgc gtcgatgaag gcgcgctcac
    14941 tctgcagccg ggcaccggcc tgcatcacgg ggtcgtcgcg gaaggcctgc gccgcgcgat
    15001 ggagcatctc ctcgaccgtc tccagcggtg tgaagccctg gatgcggatc tcttccatcg
    15061 ctgcgggcca gcgcgcgtag tgctcctcca ccacggcgat ggccagtgat tccttgctgg
    15121 ggaagtggaa gtacaccgcg cccttggtca tgccgacacg ctcggcaacg tccttgacgg
    15181 aggcccctcg gtagccgcgc gacgcgaaga tctccgacgc cgcctccagg atctgggccc
    15241 gggtcttgat cgaccgctcc tgctgcgggt gaggtccacg cggcacgttg gaccggaccg
    15301 cgaaaggcgt gggttgttgg gcgctcgtca tggctgcctt ccttcgtgtg tgcgggccct
    15361 gcgggcgcca tgctggtgcg acccgggtcg gcacggaaac ccattgcata ataccttccc
    15421 gcaggtatat ttctctcggt cagcttaccg atcccggctg tcttgcagcg cggcaagcca
    15481 gccggtggtc ccgtacgagg acacaccggg agatgtagcg cccctatgaa ccatacaaac
    15541 cgtcttttac tgcccgcccc ccacgacctc ctgttcgacg gctgccctcc gctctccttc
    15601 gcgcgccccc tgccgccggc cgacgtacac aaggctgccg cggcagaagt actcctcacc
    15661 gacgcgcgac cgctgggcga gaaccggttc gccgtcgccg ccctgtggcc ccgaaacacc
    15721 ttcctcgcgc accgcgcgac atcgagcccg tgcgaccccc tcctagccgc ggagaccata
    15781 cgacagtcgg cgatccacct ctcacacacc ttctgtgacg tgcccatagg ccaccacttc
    15841 gtgctgtcgg gcctcgatct tgatctcgat ctccctgtct gggactccgg cccgctgcct
    15901 gtcgtcctgg acgtcacgag tacgaagacc accacgaacc cgcgccggat ggccagggcg
    15961 ttgaacgccg acgtgtacgt ggccggactc caccgcggcc gctgcgccat ccgcttcgag
    16021 gtcctcgccc cccggcggta cgcgatgatc cgcgatcgcg ccaggcgggc agagcgcccc
    16081 gcacagcagg cagccgcagg cgcggcgacc gcccttcctc ccgaaaccgt cggcttccac
    16141 gacgacctgc acgtcctgct tgccaccgcg caaggcctgc ccgatacagc ctggcaactg
    16201 cggctgcgcc gggaccatcc ggtcctcttc gaccacgaat cggaccacat ttccggcatg
    16261 gcactgctgg aggcctgccg tcaggccgcc acagccctca ccccacccgc gcccggagcc
    16321 ttcggcccgc ggcaggtggc cctcacggcc gtcgcaagtt cctaccaggc attcggcgaa
    16381 ctcgactccc ctgtcaccat caccaccctc cccgccgccc acgggcacag cccggacagc
    16441 ggcacacgta cgctgcaact caccgcccgg caaggcagcc gcacgctcat caccgcgacc
    16501 gtcaccacga cgacgacagc cgggacggga agccccgggc ccaccgtccc gcaccacggc
    16561 gaccagacga aggcggtggc ctcatgaccg cgccgctcag ggagttttcc cgcgacgggg
    16621 tggaacacgc cgtggctctc gcgcaccggg accacggagt ccaggagaca caccgacgac
    16681 tcacagacga cgtggcccgg gcggtcaccg acgtcggctt tccacgccac ttcgtccccc
    16741 ggcgcttcgg cggccgcgcc gggaccttcg gcgaactgct cacggcggcg accacgctcg
    16801 cccggacctg cgccgccacc gcctggtgcg ccacgctgta tgcggcccat gggcggctgg
    16861 cctcgtacct gcccgaaaag gcccaacgcg aactgtggca ctcctcgccc gacgcccgta
    16921 tcgccgcggc catcatgccc ccgtcgggcg aggccaacct cgagccgggc ggctggcggc
    16981 tcaccgggcg ctggggattc gccagcggcg tcgaccacgc cgactgggtg ctgctcgcaa
    17041 gctggacacc gggccggaac gttcccgagc ggcaccggct gttcgccgtc cccagggacg
    17101 agctgacggt caccgacacc tggcacaccc tcggcatgcg cgggaccggc agcaacaccg
    17161 tcgaggcgga cggggtgctg gttccccgcc accgcacctg caccttgtcg gacctgctgc
    17221 tccccctgcc cggctcggcc cgctgccaca cggtgcccta cgccatggtg ggcgcgctga
    17281 tgttcgcctt tccggttctc ggggcggccc gcggagctct tgacgcctgg acacacgccg
    17341 ccacagaacg acagggcacc gcagtgcccc cggcgtccaa caccctgacc agagcagcag
    17401 cacgcatacg cgccgcaggc ctgctcctgg aggcagcggc agagcgggcc gaccacgcgc
    17461 cagtgacccc gctcctcgtc gccgaggggc agcgggacgc cgccgcggct gtggaactgt
    17521 gctccgaagc cgtcgaccaa ctgctgcgcg cctcgggatc acgtggccag gcagaagacg
    17581 acccggtaca gcgccactgg cgggacatca ccaccgctgc cacgcacagg gccctgagca
    17641 tcgacgcagc agccggcgca tacacgcctg ctctcttcga ccgtgcggac ccatcgaccg
    17701 gcgtcggccc cgccgagccg ggcggcccgg ccggcccacc cggcagaacc gcgaccgcac
    17761 cagacacaga aagacgtacg gcgtgatgcc cgagcccccg cgcgaacgtc gcacagccgc
    17821 gaaccggtcg cccgccatac gccccatcgc cttcttcgat gtggacgaga cactgatcac
    17881 cgccaagagc atgctcgact tcgcacggca ggcgccgcac agcttgcggg acgacatcac
    17941 cgcgcaggcg agcgggcaac gccacagtgc tgatgccgat ctgacggcga tgcggcgccg
    18001 aggggcgagc cgggtggaga tgaaccgcgt ctactaccgg cgctacgccg gtgtttccct
    18061 ggctcgcctg caggaggccg gccgcgactg gtaccacgct taccgcacgc ggccggacgg
    18121 ctacgtcagg gccggcctgg cggcactcgc tcggcaccgc cgggccggcc acacgatcgt
    18181 tctgatctcg ggctcggccc ggccactgct cacgcccctg gcgcaggacc tcggcgcgga
    18241 ccggattctg tgcaccgagc agttcgccga cgcccagggc gtcctcaccg gcgaggtgaa
    18301 tcgcccgatg atcggcgaag cgaaggctga ggccgtgacc gaagtgatgg cgaagagggg
    18361 ggtggtgccg gcagactgct ttgcctacgg ggaccacgag agcgacttcg gcatgctgca
    18421 ggccgtgggg aacccggtcg tggtcggcac ggacctcgtg ctggtgcgcc acgcccaggg
    18481 gtccaactgg ccggtgctgc ccgccgacgc gggaccccgc tgtgcatgcg cacggcgtcc
    18541 aggcccgcta ggccacgacg atccgtcggc catcggttga atcctgccgc gcggtagccg
    18601 tgctgcctcc acttttgcgc cgatgactgg gacatcgtcc acgtgcgccg accgccccca
    18661 ctaacatacc ttcccgaggg tatgttttcc gggcccgttg gctcacgacc ttgagaggac
    18721 tcgggcgttg gtgaagcagg caagggcgat gcgcacccgg gaccaggtgc tggatgcggc
    18781 ggctgaagag ttcgccctgc acggctatgc aggcaccaat ctggcaacgg tcgccgtacg
    18841 cacaggcatg acgaagggcg ctctctacgg gcacttccca tccaagaagg cgctcgccga
    18901 cgaactggtg agccagtcga cagagacatg gaacaccatc ggccgctcca tcgccgagac
    18961 cgcctgcgcg cccgaaaccg ccttgcgtgc cctcgtgctg gccgtaagcc gtcaaatgaa
    19021 gcacgacatc cggttccgtg cggcgctgcg gctggcagcg gactgcacca tgcccgcggg
    19081 cggggcgccg gatctcctgg accgcatccg ccgcgagatg gccgcggccg cccgtgacac
    19141 ccagcaacag caagccccct actcaccctt ggccacgcag ccaccggacg tggtggtcca
    19201 cctgctgctg accgttgcct atgggttgtc gttcgcggct gaacgagggg cgccgggacg
    19261 ctcacctgcc acgactgaca aggtgtggga actcctgctt actgcgctgc agttggagga
    19321 catttcaacc tgccacaact ga
//
