Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000915.1:
Cluster 1Other163728

BGC0000915, mitomycin biosynthetic gene cluster from Streptomyces lavendulae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: mitomycin
SMILES string: Copy to clipboard
Molecular formula: C15H18N4O5
Exact molecular mass: 334.1277 Da ([M+H]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Aminocoumarin

Gene cluster description

mitomycin (BGC0000915). Gene Cluster 1. Biosynthetic class = Other. GenBank AF127374, positions 1-63728. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Mao Y et al. (1999) Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chem Biol 6(4):251-63. doi: 10.1016/S1074-5521(99)80040-4.