LOCUS       BGC0000916             13903 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Staphylococcus carnosus NarQ-like protein gene, partial cds;
            galactose operon, complete sequence; and molybdenum cofactor
            biosynthetic gene cluster, complete sequence.
ACCESSION   BGC0000916
VERSION     BGC0000916
KEYWORDS    .
SOURCE      Staphylococcus carnosus
  ORGANISM  Staphylococcus carnosus
            Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
COMMENT     On Jan 17, 2000 this sequence version replaced AF022796.1.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 21:03:29
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(<1..158)
                     /codon_start=1
                     /note="Orf1; similar to Bacillus subtilis NarQ in
                     Swiss-Prot Accession Number P39756"
                     /product="NarQ-like protein"
                     /protein_id="AAF25546.1"
                     /transl_table=11
                     /translation="MNKDINNDIDVMTDQNIVRYEDGKLFETTDSYVTEFPLTIMVNGE
                     EFATVIC"
     source          1..13903
                     /db_xref="taxon:1281"
                     /mol_type="genomic DNA"
                     /organism="Staphylococcus carnosus"
                     /strain="TM300"
     subregion       1..13903
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000916"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13903
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            304..1302
                     /gene="galR"
     CDS             304..1302
                     /codon_start=1
                     /gene="galR"
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 169.6; E-value: 1.8e-51)"
                     /gene_kind="regulatory"
                     /note="repressor protein; LacI/GalR family"
                     /product="GalR"
                     /protein_id="AAF25547.1"
                     /transl_table=11
                     /translation="MASIRDIAKAAGVSPGTVSRILNEDPTLSVADKTRQRVLKVAEEM
                     AYQKATRMNRQVQIITYASRRREMADPFHRELRLAIETEIKRLNLTLKKTIRVESEMKK
                     QDWTEVKKAGALLVIGNFSKTALETIYQYNPNMVVINNPEVPDFIDSVYSDLEKTMLKL
                     LDRIIQKHQKAQITYFGGMREEMSLDGSITYNNDVRYQAYVQWCKSHDKTPDAHLVGWT
                     REDGEQEIESLSQLPDIVIAGNDMVAIGVIQGLQKNGKHIPSDVKVIGFNDLDVNQYVT
                     PSLTSVQIDIEQFGKSAVAMAEDRVKKVRSNALHTIVQTRLILRESYAEKE"
     gene            304..5082
                     /gene="galactose operon"
     misc_feature    310..372
                     /gene="galR"
                     /note="involved in DNA binding; Region: helix-turn-helix
                     motif"
     gene            1392..2558
                     /gene="galK"
     CDS             1392..2558
                     /codon_start=1
                     /gene="galK"
                     /note="galactokinase"
                     /product="GalK"
                     /protein_id="AAF25548.1"
                     /transl_table=11
                     /translation="MLTSMKSKFDTLFNTQPEVAAFAPGRINLIGEHTDYNGGYVFPAA
                     IELGTYGLASKRNDNKICLYSNNFESTGTIEFSLDELQFDTTHSWANYPKGMVKFLKES
                     GYQIDSGFNILIEGNIPNGASLSSSASIEILMGWLLKALFNLEVERLELIELGRKVENQ
                     FIGVNSGIMDQFIVGMGRKDQAILLDTATLEYHYVPTEFGDYVISIMNTNKRRELAESK
                     YNERLKECQSALALLQQELDVDALGHIDVTTFEKHAYLIEEDVLLRRARHAITENARVK
                     EAHAALNRKDFIEFGRLLNASHASLKNDYEVTGIELDTLAETAQQVEGVLGARMTGAGF
                     AGCAIALVHKDRIKDLEEEVTKIYKDKIGYEPSFYHVDIGDGVKYIKI"
     gene            2579..3568
                     /gene="galE"
     CDS             2579..3568
                     /NRPS_PKS="Domain: NAD_binding_4 (40-188). E-value:
                     4.7e-10. Score: 30.8. Matches aSDomain:
                     nrpspksdomains_galE_NAD_binding_4.1"
                     /codon_start=1
                     /gene="galE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     265.4; E-value: 1.2e-80)"
                     /gene_kind="biosynthetic-additional"
                     /note="UDP-glucose-4-epimerase"
                     /product="GalE"
                     /protein_id="AAF25549.1"
                     /transl_table=11
                     /translation="MSVLVLGGAGYIGSHAADQLIEQGYDVAVVDNLGTGHRQAVPETA
                     RFYEGDIRDKAFLNHVFEQENVEGVFHFCAYSLVGESVEKPLEYFNNNVYGMQVLLEVM
                     KAHDVNEIIFSSTAAVYGEPEIIPIQEDAPKAPTNPYGESKLMMEKMMHWCHNAYGVNY
                     AALRYFNVAGAKEDGSIGEDHNPETHLIPIVLQAALGQRDAITIFGTDYDTEDGSCVRD
                     YLHVTDLIAAHILAYQYLKDGGESGAFNLGSSQGYSVIEIVEAARKATGIDIKAEIGER
                     RAGDPSKLVASSDKAQRVLGWKPKHDDIHEIIETAWNWHQSHPNGYSN"
     CDS_motif       2582..2650
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_galE_0001"
                     /evalue="1.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="galE"
                     /protein_end="24"
                     /protein_start="1"
                     /score="11.4"
                     /tool="antismash"
                     /translation="SVLVLGGAGYIGSHAADQLIEQG"
     aSDomain        2699..3142
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_galE_NAD_binding_4.1"
                     /evalue="4.70E-10"
                     /label="galE_NAD_binding_4.1"
                     /locus_tag="galE"
                     /protein_end="188"
                     /protein_start="40"
                     /score="30.8"
                     /tool="antismash"
                     /translation="VPETARFYEGDIRDKAFLNHVFEQENVEGVFHFCAYSLVGESVEK
                     PLEYFNNNVYGMQVLLEVMKAHDVNEIIFSSTAAVYGEPEIIPIQEDAPKAPTNPYGES
                     KLMMEKMMHWCHNAYGVNYAALRYFNVAGAKEDGSIGEDHNPET"
     gene            3586..5082
                     /gene="galT"
     CDS             3586..5082
                     /codon_start=1
                     /gene="galT"
                     /note="galactose-1-phosphate uridylyltransferase"
                     /product="GalT"
                     /protein_id="AAF25550.1"
                     /transl_table=11
                     /translation="MNLNRQYVNRFIDDAIQYGDYEREDNYYLQNLILEITKAESIDET
                     KNNNGLVNPTSNEIAQFWIQQMLNNGLLEDVVYQKEIVETKLLDLITPKPSTINREFWK
                     RYESHPEKATGYFYQICKRNHYVKEDAIAKNIHYYTETEYGDLEITINLSKPEKDAKEI
                     AKAREAKQSSYPANALCMENEGFVGSVTQAARRNHRIVRLNLNHQPWGFQFSPYAYFPE
                     HSIVLSEAHEPMKIEKQTFSNLLQFVQKFPHYFAGSNADLPIVGGSILSHNHYQTGRHT
                     FPMDHAPEMKQFKMEQFPDVQAAILKWPMSVIRLKGEDLDEMTEAADHIFETWKSYTDE
                     KLDIRAYSQDGTRHHTVTPIARFNQTTSEYELDLVLRDNQTSTQYPDGIFHPHNDVHHI
                     KKENIGLIEVMGTAILPGRLKKELLEVERYVLGDINAEPGSHKKWADKMKEKYNFNNEN
                     AKNIIHQEVGRIFKRVLEDSGVFKQSTEGQKGFEKFIQTL"
     gene            5242..6027
                     /gene="modA"
     CDS             5242..6027
                     /codon_start=1
                     /gene="modA"
                     /note="molybdate-binding lipoprotein of the
                     molybdate-specific ABC transporter ModABC"
                     /product="ModA"
                     /protein_id="AAC83133.1"
                     /transl_table=11
                     /translation="MKIKHFLIALVAICLVLAGCSNSDSGDKKDSKKSDSNDKKQELQI
                     SAAASLTDVSKDLEKEFKKDHPDAKITFNYGGSGALRQQIEKGAPVDVFMSANTKDVDA
                     LKDKKKAHDTYNYAKNKLVLIGEKDSDIKSVKDLKDGQKLAIGEAKSVPAGKYATQYLQ
                     DNGLYDGVKDKLVYAKDVRQVLNYVEKGNAQLGYVYKTDLYPNKTKNDKVREIEQVKLK
                     KPIVYEAGATSDNKLAKDWMKFLKSDKAKKIMKEYKFEN"
     gene            6039..6710
                     /gene="modB"
     CDS             6039..6710
                     /codon_start=1
                     /gene="modB"
                     /gene_functions="transport (smcogs)
                     SMCOG1214:binding-protein-dependent transport systems
                     (Score: 137; E-value: 1.2e-41)"
                     /gene_kind="transport"
                     /note="integral membrane-spanning protein of the
                     molybdate-specific ABC transporter ModABC"
                     /product="ModB"
                     /protein_id="AAC83134.1"
                     /transl_table=11
                     /translation="MPDLTPFWISIKVAVISTIIVSILGIIISRLLYRYRGRIVTLLES
                     IIILPIVLPPTVMGFLLLIVFSPKSPVGAFFTNVLHLPVVFTLTGAVIASVVVSFPLMY
                     QHTIQGFRGINNKMLNTARTMGASENKIFFRLILPLSKRSILSGIMMAFARAIGEFGAT
                     LMVAGYIPNKTNTLPLEIYFLVEQGKENEAWLWVLVLVAFAITVIGTINMINRDKYLEV
                     D"
     gene            6711..7319
                     /gene="modC"
     CDS             6711..7319
                     /codon_start=1
                     /gene="modC"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 154.1; E-value:
                     7.9e-47)"
                     /gene_kind="transport"
                     /note="ATP-binding protein of the molybdate-specific ABC
                     transporter ModABC"
                     /product="ModC"
                     /protein_id="AAC83135.1"
                     /transl_table=11
                     /translation="MLTIQIEYQLRDHFIQLDINDDQPKIYAIRGPSGIGKTTVLNMIA
                     GLRKADRAYIKIDDHLLTDTEHDVNVKIQERGIGYLFQDYQLFPNMTVMQNITFMAKPS
                     EHIDELMRQLNIVHLTKQYPARLSGGESQRVALARALSTRPDILLLDEPFSSLDDATKE
                     ESMHLVKRMFDDWQIPIIFVTHSNYEAEQLADEIITIGS"
     gene            7471..8472
                     /gene="moeB"
     CDS             7471..8472
                     /codon_start=1
                     /gene="moeB"
                     /note="similar to the molybdopterin synthase sulfurylase
                     MoeB of Escherichia coli"
                     /product="MoeB"
                     /protein_id="AAC83136.1"
                     /transl_table=11
                     /translation="MNERYSRQILFKNIGVEGQEKISQKHVLIIGMGALGTHLADGLVR
                     AGVRKLTIVDRDYIEFSNLQRQTMYTENDAKEALPKVIAAKERLTEIRSDIEIDAYIDQ
                     VNPPFLEEHAQHVDLILDATDNFDTRLLVNDFAYKYNIPWIYGGVVQSTYIEAAFIPGQ
                     TPCFNCVMPQLPVINMTCDTVGVIQPAVTMTTSLQLRDALKILTDTPFTPKLTYGDIWE
                     GTHYTFGFSRMFDSTCTTCGPNPTYPHLHQTDQQYATLCGRDTVQYSNENITQEMLKQY
                     LDAHHIHYHANPYMLRFEFNGHRIVSFSGGRMLIHGMTKPTEAIKLMNQLLG"
     gene            8504..9016
                     /gene="moaB"
     CDS             8504..9016
                     /codon_start=1
                     /gene="moaB"
                     /note="similar to MoaB of Escherichia coli"
                     /product="MoaB"
                     /protein_id="AAC83137.1"
                     /transl_table=11
                     /translation="MTKNEHVNVKLDRDIQCAVLTVSDTRTPETDKGGNLAKELLSEIN
                     VEIKPEHYAIVKDDKQAITEQLQQWLAEDVDVIITTGGTGIAQRDVTIEAVTPLLSKEI
                     EGFGELFRYLSYAEDVGTRALLSRAVAGTVGEQLIFSVPGSTGAVKLAMNKLIKPELNH
                     LIHELTK"
     gene            complement(9200..9685)
                     /gene="moaC"
     CDS             complement(9200..9685)
                     /codon_start=1
                     /gene="moaC"
                     /note="similar to MoaC of Escherichia coli"
                     /product="MoaC"
                     /protein_id="AAC83138.1"
                     /transl_table=11
                     /translation="MSEFTHINEQGNAKMIDVSEKEITKRTATAHSSITVNQDIYQQIV
                     DHTNKKGNVLNTAQIAGIMAAKNTSTIIPMCHPLSLTGIDIAFEWDTTSSYTLNIEATV
                     STSGKTGVEMEALTAASATALTVYDMTKALDKGMVIGETYLLTKSGGKSGDYRRESK"
     gene            9750..11009
                     /gene="moeA"
     CDS             9750..11009
                     /codon_start=1
                     /gene="moeA"
                     /note="similar to MoeA of Escherichia coli"
                     /product="MoeA"
                     /protein_id="AAC83139.1"
                     /transl_table=11
                     /translation="MPVEKRNPIPVREAIKRVVEQDIETEVQNVPLNKSLGYVLAEDIV
                     ATYEIPRFNKSPYDGFALRSEDTVGASGDNRIEFEVIDHIGAGSVSDKTVGPNQAVRIM
                     TGAEVPAGADAVVMLEQTKEGDHTFTIRKTFSHNENVSLKGEETEVGDVVLKKGQRINA
                     GGIAVLATFGYTEVPVRKLPSAAIIATGSELLDVGDELEPGKIRNSNGPMIEGLLNQFG
                     LDGEVYKIQEDDLESSIAVVKQAMETHDMVITTGGVSVGDFDYLPEIYKALDAEVLFNK
                     VQMRPGSVTTVAVAHGKYLFGLSGNPSACYTGFQLFVKTGVLNMMGANEKFPQVVKATL
                     MEDFKKANPFTRFIRSKATLNGMEATVVPSGFNKSGAVVAIAHSNAMVMLPSGTRGFHA
                     GNTVDVILTETDVFEEELLL"
     gene            11006..11488
                     /gene="mobB"
     CDS             11006..11488
                     /codon_start=1
                     /gene="mobB"
                     /note="similar to MobB of Escherichia coli"
                     /product="MobB"
                     /protein_id="AAC83140.1"
                     /transl_table=11
                     /translation="MILQIVGYKDSGKTTLLAETVKFLKNKGYRVVTIKHHGHGAEDIT
                     LQENTVDHMKHFEAGADQSIVQGHELRETITRTSEASLSQIIDSAVTIEYDIILAEGFK
                     NADYDKVVIYKNPEELSSLSALSHVQYKLPFQKLSDLEPFKNWLESWIDIKKDESE"
     gene            11485..11937
                     /gene="moaE"
     CDS             11485..11937
                     /codon_start=1
                     /gene="moaE"
                     /note="similar to MoaE of Escherichia coli"
                     /product="MoaE"
                     /protein_id="AAC83141.1"
                     /transl_table=11
                     /translation="MKQFEIVTEPIQTEQHRDFTLNPHQGAVVVFTGHVREWTKGIRTE
                     HLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPLKISDIAVLIAVSSPHRKDA
                     YAANEYAIDRIKEVVPIWKKEIWEDGAEWIGHQRGYHDDAVERGQN"
     gene            11937..12170
                     /gene="moaD"
     CDS             11937..12170
                     /codon_start=1
                     /gene="moaD"
                     /note="similar to MoaD of Escherichia coli"
                     /product="MoaD"
                     /protein_id="AAC83142.1"
                     /transl_table=11
                     /translation="MKVLYFAEIKEILQKDTDQFQIDDEMTVEAFKQYLFEKYPEIDGK
                     KFQIALNEEFVQPHEKINQSDVVALIPPVSGG"
     gene            12175..12765
                     /gene="mobA"
     CDS             12175..12765
                     /codon_start=1
                     /gene="mobA"
                     /note="similar to MobA of Escherichia coli"
                     /product="MobA"
                     /protein_id="AAC83143.1"
                     /transl_table=11
                     /translation="MKAIILAGGQSERFGAPKAFAEIDGKMFYEQIITVLDSMNMFNEI
                     IISSNETLASEFKGARVIVDDSEHKNKGPLSGIYSVMKQDLNQNYFCDFCGYAAYYRKA
                     ISQLYQFMVEHVIEDQLDIAGFKEGNHPIPTIAFYSPNCLPIIARALESDDYSMRHVYQ
                     QTASDWIDVSSVDDDTEWYKNINYPQDLESIKK"
     gene            12824..13846
                     /gene="moaA"
     CDS             12824..13846
                     /codon_start=1
                     /gene="moaA"
                     /note="similar to MoaA of Escherichia coli"
                     /product="MoaA"
                     /protein_id="AAC83144.1"
                     /transl_table=11
                     /translation="MVKQITDKLGRPIRDLRLSVTDRCNFRCDYCMPKEIFGDDFVFLP
                     KDELLSFSEMERIARVYTHLGVKKIRITGGEPLMRRDLYKLIAALNEIEGVEDIGLTTN
                     GLLLKKHGQKLYDAGLRRINVSLDAIDNELFQSINNRNIKADTILEQIDYAVSIGFKVK
                     INVVVQKGVNDDQIIPMVQYFKDKNIQVRFIEFMDVGNDNGWDFSKVVSKDEMLSMIQE
                     EFDIEAVEPKYYGEVAKYYRHKDNGAQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFS
                     TVDGFNVKEFMRSGVSDDELQAKFEELWNIRDDRYSDERTEQTVAIRKRKKINMNYIGG
                     "
ORIGIN
        1 ctgcagatga cggttgcaaa ctcttctcca ttgaccataa ttgttaaagg aaattcagtc
       61 acataactgt ctgtagtttc gaacaacttt ccatcttcat aacggacaat attttgatcc
      121 gtcattacat ctatatcatt atttatatct ttattcataa gcattgactc cttactaaaa
      181 gaatatacta tattattcct cttttcaaaa aagatttgga catttatctg tataaaagga
      241 aatttaagtt gagacgaggc atttataata gtaaactcaa agtaaacaaa aggaggcggg
      301 tgtatggcaa gtattagaga tattgcaaaa gcagcaggcg tcagtccagg tacagtttct
      361 cgtatattaa acgaagaccc gacattgtca gtagctgata aaacaagaca gcgtgtgctt
      421 aaagtagcag aagaaatggc ttatcaaaag gcgacacgca tgaatcgtca agttcaaatt
      481 attacttatg cttctagaag acgagaaatg gcagatccgt ttcatcgtga attgcggtta
      541 gcaattgaaa cagaaatcaa acggttaaat cttactttaa agaagaccat tcgagttgaa
      601 tcagaaatga aaaaacaaga ttggactgag gttaaaaaag caggtgcact gttggtcatc
      661 ggtaattttt ccaaaacagc actagaaaca atttatcaat ataatcccaa tatggttgtt
      721 attaataatc ctgaggtacc tgattttatt gattcggttt attcagattt agagaaaaca
      781 atgctgaaat tactcgatag aattatacaa aagcatcaaa aagctcaaat aacatacttc
      841 ggcggcatgc gagaagaaat gtctttagac ggcagtatta cctataataa cgatgtgcga
      901 tatcaagctt atgtgcaatg gtgcaaatct catgataaaa caccggatgc acatttggtt
      961 ggttggacgc gtgaagatgg agaacaagaa attgaatctt tatctcaatt gccggatatt
     1021 gtaatagcgg gcaatgatat ggttgctatt ggtgttattc aaggtctgca aaaaaatggc
     1081 aaacacattc ctagtgatgt gaaagtcatt ggatttaatg atttagatgt aaatcaatat
     1141 gtaacgcctt ctttgactag tgtccaaatt gacattgaac aatttggaaa aagcgctgtc
     1201 gcaatggctg aagatagagt taaaaaagtc cgttcaaatg ctttgcatac gattgtacaa
     1261 acgcgtttga ttttacgaga gtcatatgct gaaaaagaat aaaatatatt ttgacaaaac
     1321 atttagtaaa cagataaact ttaattgtgt ttactaagat tatttactgt tttgtgagag
     1381 gagaaagtcc gatgttgaca tcaatgaaat caaaattcga tactttattc aatacgcaac
     1441 ctgaagtcgc tgcttttgca cctggacgaa ttaatttaat cggagaacat acagactata
     1501 atggtggcta tgtttttcca gcagccattg aacttggcac atatggttta gcaagtaaga
     1561 gaaatgataa taagatttgt ctatactcga ataattttga atcaacagga acgattgaat
     1621 tttcacttga tgaattacaa ttcgatacaa cacatagctg ggcgaactat ccaaaaggga
     1681 tggttaaatt tctaaaagaa tctggttatc aaatagattc tgggttcaat atactgatag
     1741 aaggaaacat accaaatggc gcaagtctat cttcatctgc atctatcgaa attttgatgg
     1801 ggtggttatt aaaggcactg ttcaatttag aagttgaaag attagaattg attgaacttg
     1861 gtcgtaaagt tgaaaatcaa tttattggcg taaattctgg tattatggat caattcatcg
     1921 taggtatggg acgcaaagac caagcaatac ttttagatac tgctacgtta gagtatcatt
     1981 atgtaccaac agaattcgga gattatgtta tttcgattat gaataccaat aagcgtcgtg
     2041 aattagctga atctaaatat aatgaacgtt taaaagagtg tcagagcgca ttggcattat
     2101 tacaacaaga attagatgtg gatgctttag gacatataga tgtgactaca tttgaaaaac
     2161 atgcttattt aatagaagaa gatgttttat tacgccgtgc acgtcatgcg ataactgaaa
     2221 atgcacgtgt taaagaagca catgcggctt tgaatcgaaa agatttcata gaattcggca
     2281 gactgttgaa tgcttctcat gcttcattaa aaaatgatta tgaagtaacc ggaattgaat
     2341 tggatacttt agctgaaaca gctcaacaag tagaaggtgt tctaggcgca cgtatgactg
     2401 gtgctggatt tgctgggtgt gcaattgcat tggtacataa agaccgcatt aaagatttag
     2461 aagaggaagt aaccaaaatc tataaagata aaattggata tgaaccctca ttttatcacg
     2521 ttgatattgg tgatggagta aagtatataa agatatgaaa taaggaagga tgaataaaat
     2581 gtcagtttta gtgttaggtg gagcagggta catcggcagt catgctgctg atcaattgat
     2641 agaacaagga tatgatgtag cagttgtaga taatcttgga acaggtcatc gtcaagctgt
     2701 cccggaaaca gcacgttttt atgaagggga tattagagat aaagcatttt taaatcacgt
     2761 ttttgaacaa gaaaatgtcg aaggtgtttt tcatttttgt gcatattctt tagtaggaga
     2821 atctgttgag aagccattag aatattttaa taacaatgtc tatggcatgc aagtattatt
     2881 agaagtgatg aaagcacatg atgttaatga aataattttt tcttctacag cagcagtata
     2941 cggagaacct gaaattattc caattcaaga agatgcacca aaagctccaa cgaacccata
     3001 tggtgaaagt aaacttatga tggaaaaaat gatgcattgg tgtcataacg catacggtgt
     3061 gaattatgct gcattacgtt attttaatgt tgcaggtgca aaagaggatg gaagtatcgg
     3121 tgaagaccat aacccagaaa cgcacttaat tccaatcgta ttgcaagctg cattaggaca
     3181 gcgtgatgct atcactattt tcggtacaga ttatgataca gaagacggtt catgtgttcg
     3241 cgattattta catgttacag atttgattgc ggcacatatt ttagcgtatc aatatttaaa
     3301 agacggtgga gaaagcggcg cgtttaatct aggaagcagc caaggatatt ctgtcattga
     3361 aattgtagaa gctgcacgta aagcaacagg aattgatatc aaagcagaaa ttggtgaaag
     3421 acgtgctggg gatccaagta aattggtagc atctagtgat aaagcacaac gtgtacttgg
     3481 ttggaaacct aaacatgatg atattcatga aattattgaa acagcatgga actggcatca
     3541 atcacatcca aacggatatt caaattaatt acaggaggcc ctattatgaa tttgaatcgg
     3601 caatacgtca atcgatttat tgacgatgca atacaatatg gtgattatga aagagaagat
     3661 aattattatc ttcaaaatct aatattagag attacaaaag ctgaaagtat tgatgaaact
     3721 aaaaataata atggattagt aaatccaacg tcaaatgaga ttgctcaatt ttggattcaa
     3781 caaatgctga ataatggttt actagaagat gttgtttatc aaaaagaaat agttgaaacg
     3841 aaattattag atttaattac acccaaacca tcaactatca atcgtgaatt ttggaaacga
     3901 tatgaatcgc atccggaaaa agcaacgggt tatttttatc aaatctgtaa acgtaatcac
     3961 tatgtaaaag aagatgctat tgccaaaaat atccattact atacagaaac tgagtatggt
     4021 gatttagaaa ttactatcaa tttatctaag cctgaaaaag atgctaaaga aattgccaaa
     4081 gcacgtgaag caaaacaatc gagttatcca gcgaatgcgt tatgtatgga aaatgaaggc
     4141 tttgtcggat ctgttactca agctgcacgc cgtaatcatc gtattgtgag attgaattta
     4201 aatcatcaac cttggggctt tcaattttct ccatatgcat acttccctga acatagtatt
     4261 gttttatcag aagcgcatga gcctatgaaa attgagaaac aaactttcag taatctttta
     4321 caatttgttc agaaattccc tcactatttt gcaggttcca atgctgattt gcctatcgta
     4381 ggtggttcta ttctgtctca taaccattac caaaccggcc gacatacttt cccgatggat
     4441 catgcacctg aaatgaaaca atttaaaatg gaacaatttc ctgatgtaca ggctgcaatc
     4501 ttgaaatggc cgatgagtgt tatccgattg aaaggcgaag atcttgatga aatgacggaa
     4561 gcggcagatc atatttttga aacatggaaa tcatacactg atgaaaaact ggatatcaga
     4621 gcgtatagtc aagatggcac acgtcatcac acggtaactc caattgcacg ttttaatcaa
     4681 acaactagtg aatatgaatt ggatttagtg ttaagggata atcaaacttc aacacaatat
     4741 ccagatggta tcttccatcc acacaacgat gtacatcata ttaaaaaaga aaatattggt
     4801 ttgattgaag tgatgggaac agctatttta cctggaagat tgaaaaaaga acttctagaa
     4861 gtagaacgtt atgttctagg agatattaat gctgaaccag gctcgcacaa aaagtgggca
     4921 gacaaaatga aagaaaaata taatttcaat aatgaaaatg ccaaaaatat aattcatcaa
     4981 gaagtaggaa gaatttttaa gcgtgtatta gaagattctg gtgtatttaa acaaagcacc
     5041 gaaggtcaaa aaggatttga aaaattcata caaacactgt gaagtcggct tttgacagct
     5101 tttttattac aaaaaactaa aagataacta cctgttaacc tttgcaataa aaaaattaaa
     5161 taaattttta atatatcgtg aaatttattg gatatagggg tataatcaaa agtgaaatca
     5221 ttttttttag gaggttttgt aatgaaaatc aaacattttt tgattgcatt agtagcgatt
     5281 tgtttagtgt tagcaggttg ttctaattca gacagcggag acaaaaagga cagtaaaaag
     5341 tctgacagca atgacaaaaa acaagaacta caaatttcag cagcagcgag tttaacagat
     5401 gtatctaaag atttggaaaa agaattcaag aaagatcatc cagatgctaa aatcacattt
     5461 aactatggtg gttctggtgc tttaagacaa caaattgaaa aaggtgcacc agttgatgta
     5521 tttatgtcag caaatactaa agacgttgat gcattaaaag acaagaaaaa agcacatgat
     5581 acttataact acgctaaaaa caaattagta cttatcggtg aaaaagattc agatattaaa
     5641 tctgttaaag atttaaaaga tggtcaaaaa ttagcaattg gagaagctaa atctgtacca
     5701 gccggtaaat atgctactca atacttacaa gacaatggtt tatatgatgg tgttaaagac
     5761 aaattagttt atgctaaaga cgttcgtcaa gtattgaact atgttgaaaa aggtaatgct
     5821 caattaggtt atgtttataa aacagattta tatcctaaca aaactaaaaa tgacaaagta
     5881 agagaaatcg aacaagtcaa attgaaaaaa ccgattgttt atgaagcagg tgcaacatct
     5941 gataataaat tagctaaaga ttggatgaaa ttcttaaaat ctgataaagc taaaaaaatt
     6001 atgaaagaat ataaattcga aaactaggag gaacgtaaat gcctgattta acgccatttt
     6061 ggatatccat aaaagtggct gtaatcagca cgattatcgt ttcgatactg ggcattatta
     6121 tctccagact tttatatcgt tatcgaggtc gcatagtaac tcttctagaa agtatcatta
     6181 tactgccgat tgttctgcct ccgacagtaa tggggttctt actcttaatc gtattttctc
     6241 caaaaagtcc ggtaggcgca ttcttcacaa atgttctgca tttgccggta gtatttacat
     6301 tgacgggcgc tgttatagcg tccgttgttg taagttttcc tttaatgtat caacatacga
     6361 tacaaggatt tcgcggtatc aataataaaa tgttgaatac tgcgcgaact atgggagcaa
     6421 gtgagaataa aatattcttt cgtttgattt tacctttatc taaacgttct attttatcag
     6481 gaataatgat ggcatttgca agagcaattg gggaattcgg tgcaacgctt atggttgcag
     6541 gttacattcc gaataaaacc aacaccttgc cattggaaat ttatttctta gtagaacaag
     6601 gaaaagaaaa tgaagcatgg ttatgggtgc tggtacttgt cgcctttgca atcacagtta
     6661 tcggtacaat taatatgatt aaccgtgata aatatttgga ggtggattaa atgcttacca
     6721 tccaaataga atatcaactg cgtgatcatt ttatccaact tgatattaat gatgaccaac
     6781 caaagattta tgcaatcagg ggaccgtctg gtatcggtaa aaccactgtg ctgaatatga
     6841 ttgcaggatt acgtaaagca gaccgagcat atattaagat agatgatcat ttattaacag
     6901 atactgaaca tgatgttaat gttaaaattc aagaacgtgg tattggttat ctgttccaag
     6961 attatcaact ctttccgaat atgacagtca tgcagaatat tacgtttatg gccaaacctt
     7021 cagagcatat agatgaactg atgcgtcaac tgaatattgt gcatttaact aaacaatatc
     7081 ctgcacgttt atcaggggga gaatcacaac gtgtagcgct tgcgagagcg ttaagcacac
     7141 gacctgatat cctgctttta gacgaacctt tttcaagtct agatgatgct acgaaagaag
     7201 aaagtatgca tttagttaag agaatgtttg atgattggca gattccaatt atttttgtta
     7261 cacattcaaa ctatgaagct gagcagcttg cagatgagat tattacaata ggttcatagc
     7321 ttattttgaa acataacccg acatcgtgct gaaagaattc agtgcatgtc gggtttgttg
     7381 tatcttttaa aaagtttagt ttggaaaatt gtgtcgtgct cagaatcatc atataataaa
     7441 agtaatgtac tttagaaagg ataaaaaaat atgaatgaac gctattcacg acaaatatta
     7501 tttaaaaata ttggagtgga aggtcaagaa aaaatatcac aaaaacatgt tttgattatc
     7561 gggatgggag ctttaggtac acatcttgct gatggcttag tacgtgctgg ggtacgtaaa
     7621 ttgactatcg tggatcgtga ttatattgaa ttcagcaatc tgcagcgtca aacaatgtat
     7681 acagaaaatg atgctaaaga agcattgcct aaagtaatag ctgcaaaaga aagattgaca
     7741 gaaattcgta gtgatattga aatagatgca tatatcgatc aagttaaccc gccattttta
     7801 gaagaacatg cacaacatgt ggatttaata ttagatgcaa cagataattt tgatacgcgt
     7861 ttattggtaa atgattttgc ctataaatat aatatacctt ggatatatgg gggcgttgta
     7921 caaagcacgt acattgaagc agcctttatt ccaggacaaa caccttgttt taattgtgtg
     7981 atgccgcaat tgccagtcat taatatgact tgtgatactg taggtgtaat tcaaccagct
     8041 gtcacaatga caacgagttt acagttaaga gacgcgttga aaatactgac ggacacaccc
     8101 tttacaccta aattaactta tggtgacata tgggaaggta cacattatac atttggtttc
     8161 agccgaatgt ttgattctac ttgtacaact tgcggaccga accctacgta tcctcattta
     8221 catcaaactg atcagcaata tgcgacactt tgcgggagag acaccgtaca atacagtaat
     8281 gaaaatatta cccaggaaat gttgaaacaa tatttagatg cgcatcatat ccattatcat
     8341 gcaaatccat atatgcttcg ttttgaattt aatgggcatc gtattgtgag tttctcaggt
     8401 ggaagaatgt taattcatgg tatgactaag ccgactgagg ctattaaatt aatgaatcaa
     8461 ctgttaggct agaagtagat tataaataac ggaggtcaat cgaatgacaa aaaatgaaca
     8521 tgtaaacgtt aagctagata gagatattca atgtgcggtg ttgacagtat cagatacgag
     8581 aacaccggaa acagataaag gcggcaactt agcaaaagaa ttattatctg aaattaatgt
     8641 agaaatcaaa ccagaacatt atgcgattgt taaagatgat aaacaagcga ttacagagca
     8701 attacaacaa tggttggctg aagatgtaga tgtcattatc acaactggtg gcacaggaat
     8761 tgcacaacgc gatgttacaa tagaagctgt aacaccattg ctttcaaaag aaattgaagg
     8821 tttcggagaa ttgttcagat atttaagtta tgctgaagat gttggtacac gtgctttact
     8881 ttcacgtgca gtagcaggca cagttggaga acaacttatt ttctcagtac caggttcaac
     8941 gggtgcagtg aagcttgcaa tgaataaact aattaaacca gaattaaatc atttaattca
     9001 tgaactgaca aaataaatca tccttataga cgattatcat atgatgattg aggtttataa
     9061 ttaatatatg atacgaaaaa acggaatcat tgagcagaca ttttatgtta aataaaaaat
     9121 gttgttgctc aacaattccg tattttgttc tgtttaaatt aaataactca gaacgggtat
     9181 ataatttaaa taaagaatat tatttagatt ctcggcgata gtcgccagat ttaccaccag
     9241 atttagttag aagatacgtt tctccgatga ccattccttt atctaaagct ttggtcatat
     9301 cataaaccgt taatgcagta gcagaagctg cagttaaggc ttccatctct actccggttt
     9361 taccagacgt tgaaacagta gcttcaatgt ttagagtata agatgatgtt gtatcccatt
     9421 cgaaagcaat atcaatacca gtaagtgaga gcggatggca cattggaata attgtggatg
     9481 tgtttttggc agccataatt ccagcaatct gtgcagtgtt cagcacatta cctttcttat
     9541 ttgtatgatc gacaatttgc tgataaatat cttgattgac ggtaatactt gaatgagcgg
     9601 tagcagtacg tttcgtgatt tctttttcag aaacatctat catcttcgca ttaccttgtt
     9661 cgttgatatg agtaaattca gacatgctat tcctcctcgc ttaaattatt atagcacgaa
     9721 ataaattgaa tgttaggagc agataaatta tgccagttga aaaaagaaat ccaattcctg
     9781 ttagagaagc tatcaaacgt gttgtagaac aagatattga aactgaagta caaaatgtac
     9841 cattaaataa aagtttaggg tacgtacttg cagaagatat tgtagcaaca tatgaaattc
     9901 ctagatttaa taaatcacct tatgatggtt ttgctttgag aagtgaagat acagtaggtg
     9961 caagcggtga taaccgtatt gaattcgaag tgattgatca catcggtgca ggttcagttt
    10021 cagataaaac tgtaggtcct aatcaagctg ttcgaatcat gacaggtgca gaagttccag
    10081 caggtgcaga tgctgtggtt atgctagaac aaacaaaaga aggcgaccat acatttacga
    10141 ttcgtaaaac attctctcac aatgaaaatg tttcattaaa aggcgaagaa acagaagtgg
    10201 gcgatgttgt attgaaaaaa ggacaacgta ttaatgccgg cggtattgca gtgcttgcaa
    10261 cattcggcta cacagaagtt ccagttcgta aattaccatc tgctgcaatt atcgcaacag
    10321 gcagtgaatt attagatgtc ggtgatgaat tagaaccagg taaaattcgt aattctaacg
    10381 gacctatgat tgaagggtta ttaaatcaat ttggtttaga tggagaagtt tataaaattc
    10441 aagaagatga cttagaaagt agtattgccg ttgtaaaaca agcgatggaa acacatgaca
    10501 tggtcattac tacaggcggc gtttcagtag gtgattttga ttatctgcct gaaatctata
    10561 aagctttaga tgctgaagta ttatttaata aagtacagat gagaccaggc agtgttacaa
    10621 ctgtagcggt tgcacatggt aaatatttat tcggtttatc cggaaatcca tcagcttgtt
    10681 atacaggttt ccaattattt gttaaaacag gcgtattgaa tatgatgggt gctaatgaaa
    10741 aattccctca agttgtgaaa gcaactttaa tggaagattt caaaaaagcc aatccattca
    10801 cacgttttat tagatcaaaa gctactttaa atggaatgga agcaacagtt gtaccttcag
    10861 gatttaataa atcaggtgcc gttgtagcaa ttgcacatag taatgcaatg gtgatgctgc
    10921 caagtggtac aagaggattc catgctggta atacagtaga tgttatctta acagaaacag
    10981 atgtatttga agaggaactt ttactatgat tttgcaaatc gtgggatata aagattcagg
    11041 caaaactaca ttgttagctg aaacggttaa gtttttaaaa aataaaggtt atcgtgtagt
    11101 cacaatcaaa catcatggtc atggtgcaga ggatattaca ttgcaggaga acactgttga
    11161 ccatatgaaa cattttgaag cgggagcaga tcaaagtatc gtacaaggac acgaactcag
    11221 agaaacgata acccgcacgt ctgaagcgtc tttatcccaa attattgatt cagctgttac
    11281 aattgaatat gacatcattt tagctgaagg gtttaaaaat gccgactatg ataaagttgt
    11341 catttataaa aatcctgaag aattatcttc tttatcagcg ctcagtcatg tacaatataa
    11401 gttgccgttt caaaaattaa gtgatttaga gccttttaaa aattggcttg aatcgtggat
    11461 tgatataaaa aaggatgagt cagaatgaaa cagtttgaga ttgtaacaga accgatacaa
    11521 acagaacagc atcgagactt tacacttaat ccgcaccaag gagcagtggt tgtatttaca
    11581 ggacatgtcc gagaatggac taaagggata cgcactgaac atttagaata tgaagcttat
    11641 attccaatgg ctgagaagaa actcgcacaa atcggtgatg aaattaatga acagtggcca
    11701 ggtacaattg taagtattgt acatcgaatc gggccattaa aaatttcaga tatagctgtg
    11761 ttgattgcgg tatcttctcc gcatagaaaa gatgcatacg ctgctaatga gtatgcaata
    11821 gatcgtatta aagaagttgt tcccatttgg aaaaaagaaa tttgggaaga tggagctgag
    11881 tggattggcc atcaacgcgg ctaccacgat gatgcagttg aaagggggca aaattaatga
    11941 aagtccttta ttttgctgaa atcaaagaga ttttgcaaaa agatactgat caatttcaga
    12001 ttgatgatga aatgactgtg gaagcattta aacaatattt atttgaaaaa tatccagaga
    12061 tagatggaaa gaaatttcaa attgctttaa acgaagaatt tgtacaacct cacgaaaaaa
    12121 tcaaccaatc agatgttgtt gctttgattc caccagtaag tggaggttaa tgaagtgaaa
    12181 gccattatat tagcaggagg gcaatcagaa cgttttgggg cgcctaaagc atttgcagaa
    12241 atagatggga aaatgttcta tgaacaaata attactgtat tagatagcat gaatatgttc
    12301 aatgaaatta ttataagttc aaacgaaaca cttgcatctg aatttaaagg tgcacgtgtt
    12361 attgtggacg attcagaaca caaaaataaa ggacctttat ctgggattta ttctgttatg
    12421 aaacaagatt tgaatcagaa ttatttttgt gatttctgtg gatacgccgc ttattaccgt
    12481 aaagcaatca gccaattgta tcaattcatg gtagaacatg tgattgaaga tcaattagac
    12541 attgctggtt ttaaagaagg taaccatcct attccgacaa ttgcctttta cagccctaat
    12601 tgtttgccga ttattgcacg tgctttagag tcagatgact atagtatgcg tcatgtttat
    12661 caacaaaccg catctgattg gatagatgta agtagtgtag acgatgatac agaatggtat
    12721 aagaatatta attatcccca agatttagag agcataaaga aataataatc aacgtttaac
    12781 gagatgtgtt aagcgattaa tatagataga agggggtcaa aagatggtaa aacagataac
    12841 ggataaactt ggacgtccaa ttcgtgattt aagattatct gtgacagacc gttgcaattt
    12901 ccgatgtgat tattgcatgc cgaaagaaat attcggtgac gattttgtct ttttacccaa
    12961 agatgaatta ctgagtttca gcgaaatgga acgaattgct cgcgtatata cacacttagg
    13021 tgtgaaaaaa atccgtatta caggcggaga accattaatg cgcagagatt tatataaatt
    13081 aattgcagcc ttgaatgaga ttgaaggtgt agaagatatt ggtttaacaa ccaatggttt
    13141 attactgaaa aaacatggac agaaattata tgatgcaggt ttaagacgta ttaatgtcag
    13201 tctagatgct attgataatg aactgttcca atctattaac aaccgtaata tcaaagcaga
    13261 tacaatttta gaacaaattg attatgctgt ttctattggt tttaaagtga aaatcaatgt
    13321 tgttgttcaa aaaggtgtga acgatgacca aattattcct atggttcaat atttcaagga
    13381 taagaatatt caagtcagat ttattgaatt catggatgtt ggtaatgata acggttggga
    13441 ttttagtaaa gttgtatcga aagatgaaat gctttcaatg attcaagaag aatttgatat
    13501 tgaagcggta gaacctaaat attatgggga agttgcgaaa tattaccgcc ataaagataa
    13561 tggcgcacaa tttggattga ttacaagtgt gtcacaatca ttctgctcta cttgtacaag
    13621 agcgagacta tcatctgacg gtaagtttta tggctgcttg ttcagtaccg ttgatggttt
    13681 taatgttaaa gaatttatgc gttcaggtgt ttcagatgat gaacttcaag cgaagttcga
    13741 agaattatgg aatattcgag atgatcgtta ttcagatgaa cgtacagaac aaactgtcgc
    13801 aattcgaaaa cgtaaaaaaa ttaatatgaa ctatattggc ggttaaagat acgaagaccc
    13861 gaatctcttt tctaaatagg aatgagattc gggtcttttt tat
//
