LOCUS       BGC0000918              4994 bp    DNA     linear   BCT 11-OCT-2001
DEFINITION  Streptomyces avermitilis ochronotic pigment biosynthetic gene
            cluster.
ACCESSION   BGC0000918
VERSION     BGC0000918
KEYWORDS    .
SOURCE      Streptomyces avermitilis
  ORGANISM  Streptomyces avermitilis
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 21:03:45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4994
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..513)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120:AsnC family
                     transcriptional regulator (Score: 146.3; E-value: 8.3e-45)"
                     /gene_kind="regulatory"
                     /product="asnC-family transcriptional regulatory protein"
                     /protein_id="BAB69149.1"
                     /transl_table=11
                     /translation="MYRMTTGGAAVAIDHLDGRLLVLLAREPRIGVLEMSRRLGVARGT
                     VQARLDRLQSNGVIRGFGPQVDPAALGYPVTAFATLEIRQGQGPDVRAHLTTVPEVLEL
                     HTTTGSGDMLCRLVARSNADLQRVIDRVVGFDGIVRAATAIVMENPVPLRIIPLVEQAA
                     EDRDRRE"
     source          1..4994
                     /db_xref="taxon:33903"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces avermitilis"
     subregion       1..4994
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000918"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..4994
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            606..1751
                     /gene="hpd"
     CDS             606..1751
                     /codon_start=1
                     /gene="hpd"
                     /product="4-hydroxyphenylpyruvate dioxygenase"
                     /protein_id="BAB69150.1"
                     /transl_table=11
                     /translation="MTQTTHHTPDTARQADPFPVKGMDAVVFAVGNAKQAAHYYSTAFG
                     MQLVAYSGPENGSRETASYVLTNGSARFVLTSVIKPATPWGHFLADHVAEHGDGVVDLA
                     IEVPDARAAHAYAIEHGARSVAEPYELKDEHGTVVLAAIATYGKTRHTLVDRTGYDGPY
                     LPGYVAAAPIVEPPAHRTFQAIDHCVGNVELGRMNEWVGFYNKVMGFTNMKEFVGDDIA
                     TEYSALMSKVVADGTLKVKFPINEPALAKKKSQIDEYLEFYGGAGVQHIALNTGDIVET
                     VRTMRAAGVQFLDTPDSYYDTLGEWVGDTRVPVDTLRELKILADRDEDGYLLQIFTKPV
                     QDRPTVFFEIIERHGSMGFGKGNFKALFEAIEREQEKRGNL"
     CDS             complement(1897..3486)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1272:TPR
                     repeat-containing protein (Score: 45.9; E-value: 7.2e-14)"
                     /gene_kind="other"
                     /product="hypothetical protein"
                     /protein_id="BAB69151.1"
                     /transl_table=11
                     /translation="MEIEQQQPLPSERGLSPVARRALIGAITGCFVLGGVLMLLPPAGR
                     EPAAPPAPAAGPMAGPVAQAKAAVGAGVPVALPALAALVTDHETHLRAHPRDARSWAVL
                     GAAYVAQGKGTADAAYFPKAEEALRTSLNVAPRRNAEALGALAALANARGDYREAKQWG
                     EAAVKMAPKQWPAYAQLIDAYDGLGDYKATGKTLDKLLGLRAGPAAAARAAQVYRARGW
                     REDAAAAIADATARAGSPAEQAVYWQQAGELAWERGEPEQALRYFETALRTDPDRHAAL
                     AGQGRALAALGRTSDAVNAYRAALAKQPLAAYAVELGELYESQGLGGAAQVQYYLVRER
                     VRQDAAGGVNNRLVVGQFEADHGDAEVAVRELREEWKRQPSIRVADALGWALHRAGQDQ
                     EALGFATKAMDKEHGGGVRSALYAYHRGEIERALDQLAPARRHLAEALRINPHFSPWFA
                     PMAKETLAELGEPPAEGLPGDEEVEAAEAEAAEAAEAAQTPEAAESVDPAQTEQVPPPG
                     ASTPVPQEPEAR"
     CDS             3585..4994
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261:hypothetical
                     protein (Score: 457.1; E-value: 1e-138)"
                     /gene_kind="other"
                     /product="putative oxidoreductase"
                     /protein_id="BAB69152.1"
                     /transl_table=11
                     /translation="MSRSETSPDEDPPATGNLVDRLLSGLPAEALLTDPDVTASYANDM
                     ASFCAAGTPAVVVLPRTVEQVQHVMRTATELRVPVVPQGARTGLSGAANASDGCIVLSL
                     TKMDHILEISPVDRIAVVEPGVINATLSRAVGEHGLYYPPDPSSWEMCTIGGNIGTASG
                     GLCCVKYGVTAEYVLGLDVVLADGRLMSTGRRTAKGVAGYDLTRLFVGSEGSLGIVVRA
                     TLALRPQPPQQLVLAAEFASTAAACDAVCRIMAGGHVPSLLELMDRTTVKAVNAMAHMG
                     LPETTEALLLAAFDTLDPAADLAAVGALCEAAGATQVVPADDAAESELLLQARRLSLTA
                     LEAVKGTTMIDDVCVPRSRLGAMLEGVERIAEKYALTIGVCAHAGDGNTHPTVCFDAAD
                     PEESRRARESFDEIMALGLELGGTITGEHGVGVLKKEWLAREIGPVGVEMQRAIKTTFD
                     PLGILNPGKLF"
ORIGIN
        1 tcactcccgt cggtcgcggt cctccgcggc ctgctccacc agcgggatga tccgcagcgg
       61 aacggggttc tccatgacga tcgccgtggc ggcccggacg atgccatcaa agccgacaac
      121 ccggtcgatc acacgctgga gatcggcgtt cgagcgggcc accagccggc acagcatgtc
      181 gccgctgccc gtggtcgtat gcagctccag cacctccggc acggtcgtca agtgcgcccg
      241 tacgtcgggc ccttgcccct gccggatctc gagcgtcgcg aaggccgtca ccggatatcc
      301 gagcgccgcc gggtccacct gcggtccgaa gccgcggatg actccattcg actgaagccg
      361 gtcgagccgc gcctgcacgg tgccgcgcgc gaccccgagc cgccgggaca tctcgagcac
      421 tccgatgcgc ggctcccgcg ccagcagcac caggagccgg ccgtccagat gatcgatcgc
      481 cacggcagcc cctccagtgg tcatcctgta catgcagccc cacgccatgg gcggtgcact
      541 gaacacattg tccagcggac aagccaacta ttgcgcacct tgcggaacgg agcgaccctg
      601 ccgccatgac gcagaccaca caccacactc ccgacaccgc ccggcaggcc gaccccttcc
      661 cggtgaaggg aatggacgcg gtcgtcttcg ccgtaggcaa cgccaagcag gccgcgcact
      721 actactccac cgccttcggc atgcagcttg tggcgtactc cggaccggag aacggcagcc
      781 gcgagaccgc ttcgtacgtc ctcaccaacg gctcggcacg cttcgtcctc acctccgtca
      841 tcaagcccgc caccccctgg ggccacttcc tcgccgacca tgtggccgag cacggcgacg
      901 gcgtcgtcga cctcgccatc gaggtcccgg acgcccgcgc cgcccacgcg tacgcgatcg
      961 agcacggcgc ccgctcggtc gccgagccgt acgagctgaa ggacgagcac ggcacggtcg
     1021 tcctcgccgc gatcgccacc tacggcaaga cccgccacac cctcgtcgac cggaccggct
     1081 acgacggccc ctacctcccc ggctacgtgg ccgccgcccc gatcgtcgaa ccgcccgccc
     1141 accgcacctt ccaggccatc gaccactgcg tcggcaacgt cgagctcggc cggatgaacg
     1201 aatgggtcgg cttctacaac aaggtcatgg gcttcacgaa catgaaggag ttcgtgggcg
     1261 acgacatcgc gaccgagtac tcggcgctga tgtcgaaggt cgtggccgac ggcacgctca
     1321 aggtcaagtt cccgatcaac gagcccgccc tcgccaagaa gaagtcccag atcgacgagt
     1381 acctggagtt ctacggcggc gcgggcgtcc agcacatcgc gctgaacacg ggtgacatcg
     1441 tcgagacggt acgcacgatg cgcgccgccg gcgtccagtt cctggacacg cccgactcgt
     1501 actacgacac cctcggggag tgggtgggcg acacccgcgt ccccgtcgac accctgcgcg
     1561 agctgaagat cctcgcggac cgcgacgagg acggctatct gctccagatc ttcaccaagc
     1621 cggtccagga ccgcccgacg gtcttcttcg agatcatcga acgccacggc tcgatgggat
     1681 tcggcaaggg caacttcaag gccctgttcg aggcgatcga gcgggagcag gagaagcggg
     1741 gcaacctgta ggcggcgcgg cccgggacgc ccgggaggag ctggcggcgc cggtcacccg
     1801 caacgccctg atcggcacgg ccgcggtctg actccggccg gcaccgaggg ggctgccgcg
     1861 ggttcggcac cgccggcccg tcggcggccc ccgggctcag cgggcctccg gctcctgcgg
     1921 aaccggcgtc gacgcgcccg ggggcggcac ctgctccgtc tgcgcgggat ccaccgactc
     1981 cgcggcctcc ggcgtctgcg cggcctccgc ggcctcggcg gcctcggcct cagcggcctc
     2041 cacttcctcg tcacccggca gcccctccgc gggcggctcc ccgagttcgg ctagtgtctc
     2101 cttcgccatc ggagcgaacc agggcgagaa gtgagggttg atccgcagcg cctcggccag
     2161 atggcgccgc gccggtgcca gctggtcgag cgcccgttcg atctcgccgc ggtggtacgc
     2221 gtacagggcg ctgcgcaccc cgcccccgtg ctccttgtcc atcgccttcg tggcgaagcc
     2281 gagcgcctcc tggtcctgcc ccgcccggtg cagcgcccac cccagcgcgt ccgccacccg
     2341 gatgctcggc tgccgcttcc actcctcccg caactcccgt accgccacct ccgcatcccc
     2401 gtggtcggcc tcgaactgcc cgaccaccag gcggttgttc acgccgcccg ccgcgtcctg
     2461 ccgcacccgc tcccgcacca ggtagtactg cacctgcgcc gcacccccga gcccctgcga
     2521 ctcgtacagc tcgcccagct ccaccgcgta cgcggccaac ggctgcttcg cgagagcggc
     2581 ccggtacgcg ttcaccgcgt ccgacgtccg ccccagcgcg gccagcgccc gcccctgccc
     2641 ggccagcgcc gcgtgccggt cgggatccgt ccgcaacgcc gtctcgaagt accgcagcgc
     2701 ctgctccggc tccccgcgct cccacgccag ctcgcccgcc tgctgccagt acacggcctg
     2761 ctccgccgga ctgcccgccc gcgccgtcgc gtccgcgatc gccgccgccg cgtcctcgcg
     2821 ccagccccgc gcccggtaca cctgagcggc ccgcgccgcc gccgccggcc ccgcgcgcag
     2881 gccgagcagc ttgtccagcg tcttccccgt ggccttgtag tcgccgaggc cgtcgtacgc
     2941 gtcgatcagc tgcgcgtacg ccggccactg cttcggcgcc atcttcaccg ccgcctcccc
     3001 ccactgcttc gcctcgcggt agtccccgcg cgcgttcgcc agcgcggcga gagcgcccag
     3061 cgcctcggcg ttccggcgcg gcgccacgtt cagtgacgta cgcagcgcct cctcggcctt
     3121 cgggaagtac gcggcgtcgg ccgtcccctt cccctgcgcg acgtacgcgg ccccgagcac
     3181 cgcccacgac cgcgcgtccc gcggatgggc ccgcagatgt gtctcgtgat ccgtgacgag
     3241 cgccgccagc gcgggcagcg cgacgggcac cccggccccc acggccgcct tcgcctgcgc
     3301 caccggcccc gccatcgggc ccgccgcagg cgccggcggc gccgcgggtt cccgcccggc
     3361 cggcggcagc agcatcagca ccccgccgag gacgaaacac ccggtgatcg cgccgatcag
     3421 ggcacgcctg gcaacagggg acaggccccg ctcggagggc aacggctgtt gctgttcgat
     3481 ctccatgccg ctcactgtgc gtcaatacga agaccacatc ccgggacacg aagagcaccg
     3541 cggacggggt tcacaccgat ggccccgggt gcgaacctgt gatcatgagc cgtagcgaaa
     3601 cgtcgcccga cgaagatcca ccagcgaccg gcaacctcgt ggaccgcctg ctgagcggtc
     3661 tgcccgcaga ggccctcctc accgacccgg acgtcacggc ctcctacgcg aacgacatgg
     3721 cgagcttctg cgcggcgggc accccggccg tcgtggtcct gccccgcacg gtggaacagg
     3781 tccagcacgt catgcgcacc gccaccgagc tgcgcgtccc ggtcgtcccg caaggcgccc
     3841 gcaccggcct gtcgggcgcc gccaacgcct cggacggctg catcgtgctg tccctcacca
     3901 agatggacca catcctcgag atcagtcccg tcgaccggat cgccgtcgtc gaaccgggcg
     3961 tgatcaacgc gacgctctcc cgcgccgtgg gcgaacacgg cctgtactac ccgccggacc
     4021 cgtcgagctg ggagatgtgc accatcggcg gcaacatcgg cacggcctcc ggcggcctgt
     4081 gctgcgtgaa gtacggggtg accgccgagt acgtcctcgg cctggacgtc gtcctggcgg
     4141 acgggcggct gatgagcacc ggccgccgta ccgcgaaggg cgtcgccggg tacgacctca
     4201 cccgcctctt cgtcggctcc gagggctccc tcggcatcgt cgtacgggcc accctggcac
     4261 tgaggccgca gccgccccag cagctggtgc tggccgccga gttcgcgtcg accgccgccg
     4321 cctgcgacgc ggtctgccgg atcatggcgg gcggacacgt accgtccctc ctcgaactga
     4381 tggaccgtac gacagtgaag gccgtcaacg ccatggcgca catgggcctc cccgagacca
     4441 ccgaggcgct gctgctcgcc gccttcgaca ccctcgaccc ggccgccgac ctcgccgcgg
     4501 tcggcgcgct ctgcgaggcc gcgggcgcca cccaggtcgt ccccgccgac gacgccgccg
     4561 agtccgaact cctgctccag gcgcggcggt tgtccctcac cgcactcgaa gcggtcaagg
     4621 gcacgacgat gatcgacgac gtgtgcgtac cacgctcgcg gctcggggcc atgctcgagg
     4681 gcgtcgagcg gatcgccgag aagtacgccc tgaccatcgg ggtctgcgcc cacgcgggcg
     4741 acggcaacac gcaccccacc gtctgcttcg acgccgccga ccccgaggag tcccggcgcg
     4801 cccgcgagtc cttcgacgag atcatggccc tcggcctgga gctcggcggc acgatcaccg
     4861 gggagcacgg cgtgggcgtc ctgaagaagg agtggctggc ccgcgagatc ggcccggtgg
     4921 gagtggagat gcagcgggcg atcaagacga cgttcgaccc gctgggcatc ctcaacccgg
     4981 gcaagctgtt ctga
//
