LOCUS       BGC0000923              6397 bp    DNA     linear   BCT 12-JUL-1999
DEFINITION  Pseudomonas aeruginosa pyoverdine chromophore biosynthesis gene
            cluster including PvcA (pvcA), PvcB (pvcB), PvcC (pvcC), and PvcD
            (pvcD) genes, complete cds, and transcriptional activator PtxR
            (ptxR) gene, complete cds.
ACCESSION   BGC0000923
VERSION     BGC0000923
KEYWORDS    .
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
COMMENT     On Jun 12, 1998 this sequence version replaced gi:2501839.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:26:06
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6397
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..6397
                     /db_xref="taxon:208964"
                     /map="66-70 mn"
                     /mol_type="genomic DNA"
                     /organism="Pseudomonas aeruginosa PAO1"
                     /strain="PAO1"
     subregion       1..6397
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000923"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6397
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            944..1927
                     /gene="pvcA"
     CDS             944..1927
                     /codon_start=1
                     /gene="pvcA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DIT1_PvcA"
                     /gene_kind="biosynthetic-additional"
                     /product="PvcA"
                     /protein_id="AAC21671.1"
                     /sec_met_domain="DIT1_PvcA (E-value: 2e-81, bitscore:
                     261.9, seeds: 112, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYAIAEDTLPARVLKELLLYRRRYPEHRQSASEADEIRRIEQVQL
                     PRIAAFIEAGEPIEFVLPAFPAKSPNPGKVLDSRPDMAERLSLSFLNHLCQRIQLFYAP
                     GAKITVCSDGRVFGDLVRIGDAHISAYQDALRLMIEEIGATHIGVFNLEDVRAFEAQRD
                     NHEQLRQLLIGGYAEPLESIRETLLASEEGLLLYRAITRFLYEDGLTPDYQGSKTALQR
                     DAKERAYGVIQRSWAWGALLADQFPRAIRLSIHPQPADSLKFGIHMMPTRDWLTPWHGV
                     AVNTEDRFVLMKRSEVLELGGELVQINGQPSHYRLPARAARRAAVA"
     gene            1945..2820
                     /gene="pvcB"
     CDS             1945..2820
                     /NRPS_PKS="Domain: TauD (42-275). E-value: 6.8e-42. Score:
                     135.9. Matches aSDomain: nrpspksdomains_pvcB_TauD.1"
                     /codon_start=1
                     /gene="pvcB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121:dioxygenase, TauD/TfdA (Score: 65.1; E-value:
                     9.6e-20)"
                     /gene_kind="biosynthetic-additional"
                     /product="PvcB"
                     /protein_id="AAC21672.1"
                     /sec_met_domain="TauD (E-value: 6.1e-43, bitscore: 135.9,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAYLSDQPVRLSPLRDEQGNQPRFGLLLEPGRPGMHVGELPAQW
                     LKGLARSHHLLLLRGFAAFADAESLTRYCHDFGEVMLWPFGAVLELVEQEGAEDHIFAN
                     NYVPLHWDGMYLETVPEFQVFHCVDAPGDTDGGRTTFSSTPAALQLADSSELELWRRAS
                     ARYQRSAAHYSSRSAAPIVERHPRREFPILRFCEPPVEGDASFINPSEFHYDGIAPEQR
                     GELLASLRRCLYHPQAHYAHRWRSDDLVIADNLTLLHGREAFAHRAPRHLRRVHIHAEP
                     ALRNPHLQRD"
     aSDomain        2071..2769
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvcB_TauD.1"
                     /evalue="6.80E-42"
                     /label="pvcB_TauD.1"
                     /locus_tag="pvcB"
                     /protein_end="275"
                     /protein_start="42"
                     /score="135.9"
                     /tool="antismash"
                     /translation="AQWLKGLARSHHLLLLRGFAAFADAESLTRYCHDFGEVMLWPFGA
                     VLELVEQEGAEDHIFANNYVPLHWDGMYLETVPEFQVFHCVDAPGDTDGGRTTFSSTPA
                     ALQLADSSELELWRRASARYQRSAAHYSSRSAAPIVERHPRREFPILRFCEPPVEGDAS
                     FINPSEFHYDGIAPEQRGELLASLRRCLYHPQAHYAHRWRSDDLVIADNLTLLHGREAF
                     AHRAPRHLRRV"
     gene            2872..4374
                     /gene="pvcC"
     CDS             2872..4374
                     /codon_start=1
                     /gene="pvcC"
                     /product="PvcC"
                     /protein_id="AAC21673.1"
                     /transl_table=11
                     /translation="MSHSVPNALMTGADYLDSLRDGRQVYLNGERVADVTRHRAFRNAC
                     RSIAGLYDGLHGEQRDVLTRVDAQGRRSHRFFTPAQNAEDLLGAREAIGCWSRMTYGFM
                     GRTPDYKAAFMSGLEAGAGFYGDYRHNACAWHRAFADRGLFFNHAIINPPLDRSKAIHE
                     MRDVFVHVERETDQGIVVSGAKMLATGSAITNATFVAPVASAQMEAGKAEDFAVVFFAR
                     MDNPGLRLMCRPSYEERASSPFDYPLSSRFDENDSVLLFDKALIPWEDVLVYRDLRRAT
                     GFYAESGFANLYNFQSGIRLGVKLELMIGLLSLGVRANGTQSFRGIQAALGELIALQHL
                     LQALTTAMARDPERNAAGSAVPRLEYANALRIQVPQIWKRVRELLESALGGAPLVTVSG
                     AADLRDGEARRLVDSYYRGAELEPEQRLKLFKLIWDATGSEFGARHAVYESHYSGNAEQ
                     IRLDSLAWASRRGHLAYCEAMVQRCMADYDIHGWLRGPWQHD"
     gene            4367..5014
                     /gene="pvcD"
     CDS             4367..5014
                     /codon_start=1
                     /gene="pvcD"
                     /product="PvcD"
                     /protein_id="AAC21674.1"
                     /transl_table=11
                     /translation="MTERKRWLAGCLSALLSLPLAAAVPGPDAPADLARGKAMAQKMCS
                     RCHDDDGNGGPRPNRSYPKLAGLDREYLYKQIYDLKTQRRRNPATNGRGEELSAADVVN
                     VSAWFAAQRMSAGEQTLADPRQRERGRQLFENGLAQRGVPPCVTCHGPAAQGLAALKAP
                     RLAGQWAEYLATQLHGFRDGKRGNSATMRAVAGGLEDSHIQALAGYLGSLGP"
     gene            5122..6060
                     /gene="ptxR"
     CDS             complement(5122..6060)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 287.4; E-value: 2.1e-87)"
                     /gene_kind="regulatory"
                     /note="LysR-type transcriptional activator; regulates pvc
                     gene cluster expression"
                     /product="transcriptional activator PtxR"
                     /protein_id="AAC21675.1"
                     /transl_table=11
                     /translation="MSAALERLNHLNLNHLYAFVAVAEHNSFTAAAEALGLSKSLLSEQ
                     LRRLEADLGIQLLTRTTRRMTLTDRGELLFGVAQRMLGELDGALSDVRDLQGEPSGRLR
                     ITAPQDFVKWHISSVSAAFIRQFPKVQVEMLADDQFSDLVGQRIDLAVRIGWPRDSGLH
                     ASKLCDFQQVAVATPGYLAGLPPVLQPHDLARCEWIGHTRLSTPWTWTFERQRERATVQ
                     TRGRLLANNTLAVYRLVLDGAGVSVLPSFLVAREIARGRLVRLLFGWRLPQGGIYALYP
                     SARYMPVRVRAFIESLREHLGREPFRLAQNE"
ORIGIN
        1 tgctgctcct gcacggcacc gacaccctgg cctacagcgc cgcggcgctg tccttcctgc
       61 tcctcgacct gccgatcccg gtgctgctga ccggctccat gctgccggcc ggcgcgccgg
      121 gcagcgatgc ctgggacaac ctggtcggcg ccctgcgcgt cctccaggag ggccacgcgc
      181 gcggcgtaca ggtctatttc aacgatgccc tgctgcacgg cgcgcgagtc agcaagctgc
      241 gcagcgacgc gttcgacgcc ttcgccgaac tgccgcgacc gcgccacgcc gagcatgcgc
      301 cggtgcctgc ggcgctcggc taccgccagc cgcgccggga agtgaacctc gccgtgctgc
      361 cgctctatcc agggctgcgc gccgcgcacc tgcgcgggct gctcgacagc ggcgtggaag
      421 cgctgctgct ggaatgctat ggcagcggca ccggcccgtc cgacgacgag gagctgctgg
      481 cgctgctgcg cgaagcccac gcccgcggcg tgctgctcgc cgcggtcagc cagtgcgcct
      541 acggccaggt cgagttcggc gtctacgccg ccggcagccg cctgcgcgac gccggcctgc
      601 tctcggctgg cggaatgacc cgcgaggcgg ccctgggcaa gctcttcggc ctgctcggcg
      661 ccggcctcgg acgcgacgaa gcgcaacgct ggttcgccct cgacctgtgc ggcgagaacg
      721 ccgactgacc gcccttgcgg ccgcccgccg gcggtcgctt ccttcagccc tccccgcgat
      781 acgcgacaac gccggcggcc cgcccgtgcc cggcgcccat cgtcaagctt cagcgaacag
      841 tgtttccggc cttccccggt ttatcccccg gcggcgagtc cacaggatgt cgccttccgc
      901 tgccggcccc gccggcatcc gcccacaagg aggaaacacc tgcatgtacg ccatcgccga
      961 agacaccctt cccgcacgcg tattgaaaga actgttgctc tatcgccgcc gttaccccga
     1021 gcatcgccag agcgccagcg aagcggacga gatccgccgc atcgaacagg tccagttgcc
     1081 gcgcatcgcc gccttcatcg aagccggcga gcccatcgaa ttcgtcctgc cggcgtttcc
     1141 ggccaagtcg ccgaaccccg gcaaggtcct cgacagccgt ccggacatgg ccgagcgcct
     1201 gtcgctgtcg ttcctcaacc acctgtgcca gcgcatccag ctgttctatg caccgggcgc
     1261 gaagatcacc gtctgctccg acggccgggt gttcggcgac ctggtgagga tcggcgatgc
     1321 gcacatcagc gcctaccagg atgccttgcg cctgatgatc gaggagatcg gcgccaccca
     1381 tatcggcgtg ttcaacctgg aggacgtacg cgccttcgag gcccagcgtg acaaccacga
     1441 gcagctccgc cagttgctga tcggcggcta cgccgagccg ctggaaagca tccgcgagac
     1501 cctgctggcc agcgaagaag gcctgctgct gtaccgcgcc atcacccgtt tcctctacga
     1561 ggacggcctg acccccgact accagggttc gaagactgcc ctgcaacgcg acgccaagga
     1621 gcgcgcctac ggggtgatcc agcgcagctg ggcctggggc gcgctgctgg ccgaccagtt
     1681 cccccgcgcg atccgcctgt ccatccatcc gcagccggcg gacagtctga agttcggcat
     1741 ccacatgatg ccgacccgcg actggctgac gccctggcac ggcgtggcgg tgaacaccga
     1801 ggaccgcttc gtgctgatga agcgcagcga ggtgctggaa ctcggcggcg agctggtgca
     1861 gatcaacggc cagcccagtc actaccgcct gccggccagg gccgcccggc gcgccgccgt
     1921 ggcctgagcc cgaggagcca gacgatgaac gcctatctca gcgatcaacc ggtacgtctc
     1981 tcgccgctgc gcgacgaaca gggcaaccag ccgcgcttcg gcctgctgct ggagcccggc
     2041 cgccccggca tgcacgtcgg cgagctgccg gcgcagtggc tcaagggcct ggctcgcagc
     2101 caccacctgc tgctcctgcg cggcttcgcc gccttcgccg acgccgagag cctgacccgc
     2161 tactgccacg acttcggcga agtcatgctg tggccgttcg gcgcggtgct cgagctggtg
     2221 gaacaggaag gcgccgagga ccacatcttc gccaacaact acgtgccgct gcactgggac
     2281 ggcatgtacc tggagacggt cccggaattc caggtgttcc actgtgtcga cgcgcccggc
     2341 gacacggacg gcggccgcac caccttcagc tcgaccccgg cggcgctgca actggccgac
     2401 agtagcgagc tggaactctg gcgccgcgcc agcgcgcggt accagcgcag cgcggcgcac
     2461 tacagcagcc gctcggcggc gccgatagtc gagcgccacc cgcgccgcga attccccatc
     2521 ctgcgtttct gcgaaccgcc ggtcgagggc gacgccagct tcatcaaccc ctccgagttc
     2581 cactacgacg gcatcgcccc ggaacagcgc ggcgaactgc tcgccagcct gcgccgctgc
     2641 ctgtaccacc cacaggcgca ctacgcccac cgctggcgca gcgacgacct ggtgatcgcc
     2701 gacaacctga ccctgttgca cggtcgcgag gccttcgccc accgcgcgcc gcgccacctg
     2761 cggcgggtgc atatccacgc cgagccggcg ctgcgcaacc cgcacctgca gcgcgactga
     2821 ccgccccgcc ggccgtgcgc gccacggccg gcgtcccgac aaggaaccag catgagccat
     2881 tctgtcccca acgcgctgat gaccggcgcc gactatctcg acagcctgcg cgacggtcgc
     2941 caggtctacc tcaacggcga acgggtcgcc gacgtcaccc ggcacagggc gttccgcaac
     3001 gcctgccgca gcatcgccgg gctctacgac ggcctccacg gcgagcagcg cgacgtcctc
     3061 acccgggtcg atgcccaggg ccgccgcagc caccgcttct tcacccccgc gcagaacgcc
     3121 gaggacctgc tcggcgcgcg cgaggcgatc ggctgctggt cgcgcatgac ctacggcttc
     3181 atggggcgta ccccggacta caaggcggcg ttcatgtccg ggctggaggc cggcgccggc
     3241 ttctacggcg actaccggca taacgcttgc gcctggcacc gcgctttcgc cgaccgcggg
     3301 ctgttcttca accacgcgat catcaatccg ccgctggacc gcagcaaggc gatccacgag
     3361 atgcgcgacg tgttcgtcca cgtcgaacgc gagaccgacc agggtatcgt cgtcagcggg
     3421 gcgaagatgc tcgccaccgg cagcgccatc accaacgcca ccttcgtcgc cccggtcgcc
     3481 tcggcgcaga tggaggccgg caaggccgag gacttcgctg ttgtgttctt cgcccgcatg
     3541 gacaaccccg gcctgcgcct gatgtgccgg ccatcctacg aggagcgcgc gagcagtccc
     3601 ttcgactatc cgctgtccag ccgcttcgac gagaacgaca gcgtgctgct gttcgacaag
     3661 gcgctgattc cctgggagga cgtcctggtc taccgcgacc tgcgccgcgc caccggcttc
     3721 tatgccgagt cgggcttcgc caacctgtac aacttccagt ccggcatccg cctcggggtg
     3781 aagctggagc tgatgatcgg cctgctttcc ctcggcgtgc gcgccaatgg cacccagagc
     3841 ttccgcggga tacaggctgc cctcggcgag ctgatcgccc tgcagcacct gctgcaggcg
     3901 ctgaccaccg ccatggcccg cgacccggag cgcaacgccg ccgggtcggc ggtgccgcgc
     3961 ctggagtacg ccaatgccct gcgcatccag gtgccgcaga tctggaagcg ggtccgcgag
     4021 ctgctggaaa gcgccctcgg cggcgccccg ctggtcaccg tctcgggcgc cgccgacctg
     4081 cgcgacggcg aggcgcggcg gctggtggac agctactacc gcggtgccga gctggagccg
     4141 gagcagcgcc tgaagctgtt caagctgatc tgggacgcca ccggcagcga gttcggcgcg
     4201 cgccacgcgg tctatgagag ccattattcc ggcaatgccg agcagatccg cctcgactcg
     4261 ctggcctggg ccagccgtcg cgggcacctg gcctactgcg aagcgatggt ccagcgctgt
     4321 atggccgact acgacatcca cggctggctg cgggggccct ggcagcatga ctgagcgcaa
     4381 acgctggctg gccggctgcc tctcggccct gctttccctg ccgctggccg ccgccgtgcc
     4441 gggcccggac gcgcccgccg acctggcgcg cggcaaggcg atggcgcaga aaatgtgctc
     4501 gcgctgccac gacgacgacg gcaacggcgg gccgcggccg aaccgcagct acccgaagct
     4561 cgccgggctc gaccgggaat acctgtacaa gcagatctac gacctcaaga cccagcgccg
     4621 gcgcaacccg gccaccaacg gccgcggcga ggagctgagc gcggcggacg tggtcaacgt
     4681 ctccgcctgg ttcgccgccc agcgcatgag tgccggcgag cagaccctgg ccgacccgag
     4741 gcaacgcgaa cgcggccgcc agctcttcga gaacggcctg gcgcagcgcg gcgtaccgcc
     4801 ctgcgtcacc tgccacgggc ccgccgccca gggcctggcg gcgctgaagg cgccgcgcct
     4861 ggccgggcaa tgggcggaat acctggcaac ccagttgcac ggcttccgcg acggcaagcg
     4921 cggcaacagc gcgaccatgc gcgcggtcgc cggcggcctg gaggatagcc acatccaggc
     4981 gctcgccggc tacctgggca gcctggggcc gtagggcgaa taaccgctcg cggttatccc
     5041 gccgcctatc cacgacgtcg gcggcggata acgcctgtgg cgttattcgc cctacagccc
     5101 ccccagcacg gatgcccagc ttcattcgtt ctgcgccagg cggaacggct cgcgaccgag
     5161 atgctcgcgc agcgactcga tgaacgccct gacccgcacc ggcatgtagc gcgccgaggg
     5221 gtacagggca tagatgccgc cctgcggcag gcgccaacca aacagcagcc ggaccagccg
     5281 tccgcgggcg atctcgcggg ctaccaggaa gctcggcagc acgctgacgc cggcaccgtc
     5341 gagcaccagg cggtacaccg ccagggtgtt gttcgccagc aggcgccctc gggtctgtac
     5401 cgtggcacgc tcgcgctggc gttcgaaggt ccaggtccag ggcgtgctca ggcgggtatg
     5461 gccgatccat tcgcaacgcg ccaggtcgtg cggctggagc accggcggca ggccggcgag
     5521 gtatcccggc gtcgccacgg caacctgctg gaagtcgcac agcttgctgg catgcaggcc
     5581 ggagtcgcgc ggccagccga tacgtactgc gagatcgatg cgctggccga ccagatcgct
     5641 gaactggtca tcggccagca tttccacctg gaccttggga aactgccgga tgaacgccgc
     5701 ggaaacgctg ctgatgtgcc acttgacgaa gtcctgcggc gcggtgatgc gcaaccggcc
     5761 actgggctcg ccctgcaggt cgcgcacatc ggagagcgcg ccgtccagct cgccgagcat
     5821 gcgctgggcc acgccgaaca gcagttcgcc gcgatcggta agggtcatgc gacgggtggt
     5881 acgggtcagc aactggatcc cgaggtcggc ctccaggcgt cgcaactgct cgctgagtag
     5941 cgatttcgac aagcccaggg cctccgccgc ggcggtgaag ctgttgtgtt cggcgacggc
     6001 gacgaaggca tacaagtgat tcaggttcag atgattcaat cgctccaggg cggcgctcat
     6061 cctgtcattc cttagccggg aagtgggtcc ggacgggtct tgtcgaaaaa tcctgctgcg
     6121 acggaacggc ggcattcgac aggacccgca acgatcggtg agcgtgatga cgcgaccggg
     6181 cggtcaggtc gtcgataaag accgccaggc gcgcataagt ttcagcgcgc caccttcgtt
     6241 ttccgataaa tgagaactgc ttcagacggt cggccgggtg cttttcatgt cagcgaagct
     6301 cgcctgatga tcgctttcta ccgacaaaac cttcttaaag tagtttctca agtattggac
     6361 aaacttcctt ttattatgga gatatggcac attcatc
//
