LOCUS       BGC0000933              5189 bp    DNA     linear   BCT 24-JUN-2014
DEFINITION  Streptomyces xiamenensis strain MCCC 1A01550 xiamenmycin
            biosysthesis gene cluster, complete sequence.
ACCESSION   BGC0000933
VERSION     BGC0000933
KEYWORDS    .
SOURCE      Streptomyces xiamenensis
  ORGANISM  Streptomyces xiamenensis
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 21:06:02
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5189
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1563
                     /NRPS_PKS="Domain: AMP-binding (23-395). E-value: 2.9e-69.
                     Score: 225.4. Matches aSDomain:
                     nrpspksdomains_AGY49247.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     271.1; E-value: 2.5e-82)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyltransferase"
                     /product="XimA"
                     /protein_id="AGY49247.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-69, bitscore:
                     222.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQEHRVDIPENLTRRWAEHAREKGWSERTAFHADGRAWTFAEVF
                     DGAARVAAGYRSHGLRTGDRVLLALPDSVEMVWCLLGAWQAGLVAVPVNVQMSRMDLTR
                     DVVTAEPALVVVDPETAGWLGDSGPAPTTEVVPLVAAEPEEAFATGGNAAALAVFTSGT
                     TGAPKLCFFRHRDLGAPRAPGLVSGPDTVGLSVSRMYFVGGLSASVFTTLETGQVAVLS
                     RPRATPAAAVELMRRHNVTVLFAQPSFLARLLLEPGHAEVLGNVRQAFCAGEVFTARLR
                     EQLVPIMGPRLLNTYGTTEAGAVAVGPPAVYDVPSAVGPPLPGRPVRVVDADGHELPTG
                     SMGELHIRVPIATRGVAHGSLGPDILTDVWWPTGDLASIDENGVVHAHGRLDDIEVIGG
                     QNLVPSEVERLLESHPRVLEAAVSSVWRPAGDTSLRAYVVAAAAPGSSDEGPVRGDDAL
                     AAELVELARSTLSWYKVPQDVVWLDTLPRNGNGKLLRRVLRAQGDEFIQPHRHYPASNA
                     PRT"
     source          1..5189
                     /db_xref="taxon:408015"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces xiamenensis"
                     /strain="MCCC 1A01550"
                     /type_material="type strain of Streptomyces xiamenensis"
     misc_feature    1..5189
                     /note="xiamenmycin biosysthesis gene cluster"
     subregion       1..5189
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5189
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        70..1185
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AGY49247.1_AMP-binding.1"
                     /evalue="2.90E-69"
                     /label="AGY49247.1_AMP-binding.1"
                     /locus_tag="AGY49247.1"
                     /protein_end="395"
                     /protein_start="23"
                     /score="225.4"
                     /tool="antismash"
                     /translation="KGWSERTAFHADGRAWTFAEVFDGAARVAAGYRSHGLRTGDRVLL
                     ALPDSVEMVWCLLGAWQAGLVAVPVNVQMSRMDLTRDVVTAEPALVVVDPETAGWLGDS
                     GPAPTTEVVPLVAAEPEEAFATGGNAAALAVFTSGTTGAPKLCFFRHRDLGAPRAPGLV
                     SGPDTVGLSVSRMYFVGGLSASVFTTLETGQVAVLSRPRATPAAAVELMRRHNVTVLFA
                     QPSFLARLLLEPGHAEVLGNVRQAFCAGEVFTARLREQLVPIMGPRLLNTYGTTEAGAV
                     AVGPPAVYDVPSAVGPPLPGRPVRVVDADGHELPTGSMGELHIRVPIATRGVAHGSLGP
                     DILTDVWWPTGDLASIDENGVVHAHGRLDDIE"
     CDS_motif       463..522
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AGY49247.1_0001"
                     /evalue="1.20E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="AGY49247.1"
                     /protein_end="174"
                     /protein_start="154"
                     /score="15.0"
                     /tool="antismash"
                     /translation="ALAVFTSGTTGAPKLCFFRH"
     CDS             1788..2729
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /note="4-hydroxybenzoate geranyltransferase"
                     /product="XimB"
                     /protein_id="AGY49248.1"
                     /sec_met_domain="ubiA (E-value: 3.1e-41, bitscore: 129.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDISAQPSQQSTRYRFVVPSIAASVVPSAPKAVLPYLQLARMHA
                     PIGSWLYLLPGLWGIALASAGLPDWRQVLLFTVGGVLVRGFGCVVNDLADRKFDARVAR
                     TVGRPLVAGTVTVTGALVFAVVQAVAGLLVLAAASVPAAVFVAASYPLVVAYPFMKRIT
                     YWPQAWLGMVFGCYILAGWLAVAGRIETPALLLFVAGVFWTLGYDTIYAHQDKADDVQV
                     GVKSLALRLGRATRPWVAGFYGATVVGIVAAGAVADLHWTFYALFLPGVAHLLWQVVTV
                     DIDSPADCREKFMANRFFGWLVLVAIVAGRVF"
     CDS             2795..3385
                     /codon_start=1
                     /note="chorismate lyase"
                     /product="XimC"
                     /protein_id="AGY49245.1"
                     /transl_table=11
                     /translation="MRTESRSLAQFVALLREPASLATEVLEEWCGAPVTAEIRHRADGQ
                     LLVPPAERTFGGGSAQAERAPFLPPERVAELMRLSTGARVQFRTVYLRAGTEKVVTAGA
                     VVALERISPEEHAVLSTTNAPLGPVLAAGGGVRRVMVTSEPTRLDPAVRPPCDADAPVL
                     TVTALLCRGTMPVGLVREAFLPCLLDRDAVHDA"
     CDS             3394..4815
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246:monooxygenase FAD-binding (Score: 318.2; E-value:
                     1.5e-96)"
                     /gene_kind="biosynthetic-additional"
                     /note="oxidoreductase subunit A"
                     /product="XimD"
                     /protein_id="AGY49246.1"
                     /transl_table=11
                     /translation="MPNSPAAVFERLTTTVPPVRIEVRLGTACVLGGGVAGLVAARVLA
                     DHANRVVIIEPDLPEAALSGAARPGVPQGSQVHLLLPGGRAQLERFFPGVVAEALAGGA
                     VSCGPERTATYLDDIEQIATPNARFLGSSRPFLETLIRRRALALPNVELVSGRVIGLRY
                     ARGAVESVRYAVGGDHVVAPADFVVDASGRGSRLSDWLEQGGWPRPETQRLQTDIRYLS
                     ARFTRSADWDGPLSGISRYSPHFPKDIAGAAVNPIENQQWVVMLAHFGNGAEGRTADEF
                     VARCRELPPIFQEAVKGEIVGEVVPYRHPDSRWRHFEALDRFPARLAVLGDAVASFNPL
                     YGQGMSSAALHASCLSEFLRSGPDLDAPARHFLELEKVVVEAAWQTSTAGDAIRLGLAT
                     PPATDQGRRQAWALRQVREAAGRDEQVGTALRAVGFMTAHPASLMAPDLVLRAARVNGV
                     PEERIRQEYTMMETT"
     CDS             4815..5189
                     /codon_start=1
                     /note="oxidoreductase subunit B"
                     /product="XimE"
                     /protein_id="AGY49249.1"
                     /transl_table=11
                     /translation="MGQTTHTALDRYMELADRAVRDPSALAELPTIFAPDATVTLRDEP
                     VTGMPAIMEFYRVFVAAVAESKHYWTTTILEDGTIESHWVVAARRADGSLMTAAGVEHA
                     TVDTDGLITNLRNRYTRTPG"
ORIGIN
        1 atgagacagg agcatcgggt ggacataccc gagaacttga cgcgccgttg ggcggagcat
       61 gcgcgcgaga aggggtggag cgaacggacc gcgttccatg ccgacggccg ggcgtggacc
      121 ttcgcggagg tgttcgacgg ggcggcgagg gtggcggccg gataccggtc gcacggtcta
      181 cgcaccggtg accgggtgct gctcgccttg cccgacagtg tggagatggt ctggtgtctg
      241 ctcggcgcgt ggcaggcggg tctcgtcgcg gtgccggtga acgtccagat gagccggatg
      301 gatctgacgc gcgacgtggt cacggctgaa ccggcgcttg tcgtggtcga cccggagacc
      361 gccgggtggc tcggggacag cgggccggct cccaccaccg aggtcgttcc gctcgtggct
      421 gcagagccgg aggaggcatt cgccacgggc gggaacgccg ccgcgctggc tgtgttcacc
      481 tccggcacca ccggggcgcc gaagttgtgc ttcttccgcc accgcgacct cggcgcccca
      541 cgcgcgcctg gcctggtgag cggacccgac accgtcgggc tctcggtgtc gcgcatgtac
      601 ttcgtgggcg ggctgagcgc gtcggtgttc accaccctcg aaaccgggca ggtggccgtg
      661 ctgtcgcggc cccgcgcgac cccggccgcc gcggtcgagc tcatgcggcg ccacaacgtc
      721 accgtcctgt tcgcgcagcc gagcttcctg gcgcggctgc tgctcgaacc cggccatgcc
      781 gaggtactgg gtaacgtccg tcaggccttc tgcgccgggg aagtgttcac cgcgcgactg
      841 cgcgagcagc tggtcccgat catgggcccc cggctgctca acacctacgg aacgacggaa
      901 gccggtgccg tcgcagtcgg cccgcccgcg gtctacgacg tgccgtcggc ggtcggtccg
      961 cccctgcccg gcaggccggt gcgtgtcgtc gacgccgacg gacacgagct gcccacgggc
     1021 agcatgggcg agctgcacat ccgcgtcccc atcgccaccc gcggcgtcgc ccacggcagc
     1081 ctcggacccg acatcctgac cgacgtgtgg tggccgaccg gcgacctcgc ctccatcgac
     1141 gagaacggtg ttgtgcacgc gcatggccgg ctcgacgaca tcgaggtgat cggcggacag
     1201 aacctggtgc cgagcgaggt cgaacgcctg ctggagagcc acccgcgcgt gctggaggcg
     1261 gcggtcagct ccgtgtggcg cccggccggg gacacgagcc tgcgcgccta cgtcgtcgcc
     1321 gccgcggcac ccggctcgtc cgacgaaggg ccggtgcggg gtgacgacgc gctcgccgcc
     1381 gaattggtcg agctcgcccg atccaccctg tcctggtaca aggttccgca ggacgtcgta
     1441 tggctggaca cactgccccg caacggcaac ggcaaattgc tgcgcagggt actccgcgca
     1501 cagggcgacg agttcatcca gccccatcgt cactatccgg cgtcgaatgc gcctcgaacg
     1561 tgaacacggt tcggcaaaca ccgttaggac aaggcggcgt tgacgcaacg gcttactgcg
     1621 ccgccaacga atcgatggcc catcaggaag acaccacagc cgacaaattg aggataacgg
     1681 gacgagatcg gcgcggcgcg aacaaacgtg tccgagatca cggggaaacc gtgttagccg
     1741 aggtgggctt tctgcaagag tcacaacaat aaccctcgcc cggtcaggtg atcgatattt
     1801 ccgctcaacc ctcgcagcag agcacgcgat atcggttcgt cgtgccgagc atcgcggcgt
     1861 cggtcgtgcc gagtgcgccg aaggccgtcc tcccctatct acaactggcg cgtatgcacg
     1921 cgcccatagg cagttggctg tacctcctcc ccggcctgtg ggggatcgcg ctcgcctcgg
     1981 cggggctgcc cgactggcgc caggtgctgc tgttcacggt cggtggggtg ctggtgcgcg
     2041 gcttcggctg cgtcgtcaac gaccttgccg accgcaagtt cgacgcccgg gtggcacgta
     2101 ccgtcgggag gccgctcgtg gccggtacgg tcacggtcac gggagcgctt gtcttcgccg
     2161 tggtgcaggc ggtggcgggg ctgctcgtgc tggctgcggc cagcgttccg gcggcggtgt
     2221 tcgtggccgc ctcctatccg ctcgtggtcg cgtacccgtt catgaagcgg atcacctact
     2281 ggccgcaggc ctggctgggg atggtcttcg gctgctacat cctcgcgggt tggctcgcgg
     2341 tggccgggag gatcgagact cccgcgctcc tgctcttcgt cgccggtgtc ttctggacgc
     2401 tggggtacga cacgatctac gcccaccagg acaaggcgga cgacgtgcag gtgggggtga
     2461 agtccctcgc gctgcgcctc ggcagggcga cccggccctg ggtcgccggg ttttacgggg
     2521 cgaccgtggt cgggatcgtg gctgccggag ccgtcgccga tctgcactgg acgttctacg
     2581 cgctgtttct gccgggcgtg gcacacctgc tctggcaggt ggtgacggtg gacatcgaca
     2641 gccctgccga ctgccgggaa aagttcatgg caaaccgttt cttcgggtgg ctcgtgctcg
     2701 tcgccatcgt tgcggggaga gtcttttgag gcgcggccac gcggtcgcac cggagcgacg
     2761 gcggaggaga tacatgtatg caggcccctg gtccgtgcgc acggagtcgc gcagcctggc
     2821 ccagttcgtg gcgctcttgc gggagccggc gagtttggcc accgaggtgc tggaggagtg
     2881 gtgcggtgct ccggtcaccg cggagatccg ccaccgcgcg gatggccaat tactcgtccc
     2941 gccggctgag cggacattcg gcgggggttc ggcgcaggcg gagcgagccc ccttcttacc
     3001 gccggagcgg gtggccgaac tgatgcggct ctcgacgggt gcccgtgtgc agttccgcac
     3061 cgtttacctg cgcgccggga ccgaaaaggt cgtcaccgcg ggcgccgtcg tggcgctcga
     3121 gcgcataagc cccgaggaac acgccgtgct cagcaccacc aacgcaccgc tggggccggt
     3181 gctggccgcg ggcggtggag tgcggcgcgt gatggtcacg tccgaaccga cccgcctcga
     3241 ccccgccgtg cgaccgccct gcgacgccga cgctcccgtg ctgaccgtca ccgcgctgct
     3301 gtgtcgtgga accatgcccg tcggcctcgt gcgggaggct ttcctgccgt gtctcctcga
     3361 tcgagacgcc gtccacgacg catgagggat cccatgccga actctcccgc cgcggtcttc
     3421 gagcggctca ccaccaccgt cccgccggtc cgcatcgagg ttcgtctcgg caccgcctgc
     3481 gtgctcggcg gcggcgtcgc cggcctggtc gcggcccgcg tactcgcgga ccacgccaac
     3541 cgtgtcgtga tcatcgagcc cgacctgccg gaagccgcgc tcagcggcgc ggctcgtccc
     3601 ggcgtcccgc agggctccca ggtgcacctc ctgctgcccg gcggacgcgc gcagctcgaa
     3661 cgcttcttcc ccggtgtcgt ggcagaggcc ctcgccgggg gtgctgtgtc gtgcggtccg
     3721 gagcgcaccg ccacctacct cgacgacatc gagcagatcg ccacgcccaa cgcgcggttc
     3781 ctggggagca gtcgcccctt cctggagacg ctgatccgtc ggcgcgcgct cgcactgccc
     3841 aacgtcgagc tggtgagtgg acgcgtcatt gggctgcggt acgcgcgcgg cgccgtcgag
     3901 tcggtgcgct acgcggttgg cggcgaccac gtcgtcgccc cagccgactt cgtcgtcgac
     3961 gcctccggcc gcggcagcag gctgagtgac tggctggagc agggcggctg gccccgaccg
     4021 gagacgcaac ggctccagac cgacatccgc tacttgtctg cccgtttcac gcgctcggcc
     4081 gactgggacg gccccctcag cggcatctcc cgctacagcc cgcatttccc gaaggacatc
     4141 gccggagcgg cggtcaaccc gatcgagaac caacagtggg tggtgatgct cgcccacttc
     4201 ggcaacggcg ccgagggccg cacggccgac gagttcgtcg cccggtgccg tgagctgcca
     4261 ccgatcttcc aggaagccgt caagggcgaa atcgtcggcg aggttgtccc gtaccgccac
     4321 cccgacagca ggtggcgcca cttcgaggcg ctcgaccgct tccccgcccg cctggcggtc
     4381 ctcggcgacg ccgtcgcctc gttcaacccc ctgtacgggc aaggtatgtc ctcggccgcg
     4441 ctccacgcct cctgcctgtc ggagttcctg cgctctggcc ccgacctgga cgccccggcc
     4501 cggcacttcc tcgagctgga aaaggtcgtc gtcgaagccg cgtggcagac gtccacggcc
     4561 ggcgacgcca tccggctggg cctggcaacg ccaccggcca ccgatcaggg gcggcggcag
     4621 gcgtgggccc tgcgacaggt acgggaggca gcgggccggg acgagcaggt cggcacggcc
     4681 ctgcgggcgg tggggttcat gaccgcccat ccggcgtcgc tgatggcacc ggatttggtg
     4741 cttcgcgcgg cgcgggtcaa tggtgtgccg gaggagcgga tccggcagga gtacacgatg
     4801 atggagacga cgtgatgggc cagacgacgc acacagcact cgaccgctac atggagctcg
     4861 ccgaccgcgc cgtgcgggac ccctcggcgc tggcggagct ccccacgatc ttcgcgcccg
     4921 acgccaccgt gacgctgcgc gacgagccgg tgaccggcat gcccgccatc atggagttct
     4981 accgggtgtt cgtggcggcg gtggccgaga gcaagcacta ctggacaacc acgatcctcg
     5041 aggacggcac gatcgagtcg cactgggtcg tcgcggcgcg ccgggccgac ggcagcctga
     5101 tgaccgcagc cggggtcgag cacgcgaccg tcgacaccga tgggttgatc acgaacctgc
     5161 gcaaccggta cacccgtacg ccgggctga
//
