Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000934.1:
Cluster 1Other125554

BGC0000934, endophenazines biosynthetic gene cluster from Kitasatospora sp. HKI. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: 5-Acetyl-5,10-dihydrophenazine-1-carboxylic acid
SMILES string: Copy to clipboard
Molecular formula: C15H12N2O3
Exact molecular mass: 269.0925 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Phenazine

Gene cluster description

endophenazines (BGC0000934). Gene Cluster 1. Biosynthetic class = Other. GenBank KJ207079. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Keishi Ishida (Leipniz Institute for Natural Product Research and Infection Biology)

Literature references

1. Heine D et al. (2014) Genomics-guided discovery of endophenazines from Kitasatospora sp. HKI 714. J Nat Prod 77(4):1083-7. doi: 10.1021/np400915p. Epub 2014 Mar 11.
2. Haagen Y et al. (2006) A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042. Chembiochem 7(12):2016-27. doi: 10.1002/cbic.200600338.
3. Bringmann G et al. (2007) Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042. J Org Chem 72(11):4198-204. doi: 10.1021/jo0703404. Epub 2007 May 3.
4. Haagen Y et al. (2007) A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. FEBS Lett 581(16):2889-93. doi: 10.1016/j.febslet.2007.05.031. Epub