BGC0000935: esmeraldin biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 29,897 nt. (total: 29,897 nt).
This entry is originally from NCBI GenBank JF417969.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000935
Short description esmeraldin biosynthetic gene cluster from Streptomyces antibioticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The esmeraldin biosynthetic gene cluster was identified on a dispensable giant plasmid."
Biosynthetic class(es)
  • other (aminocoumarin)
  • PKS (Unknown)
Loci
JF417969.1
via Knock-out studies
Compounds
  • esmeraldin
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
esmeraldin Evidence:
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C38H28N4O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFB35615.1
  • esmT3
 152 - 1624 (+) Integrin-like protein
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    • AFB35616.1
    • esmT4
    		 1695 - 2423 (+) Transcriptional regulation
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      • AFB35617.1
      • esmT5
      		 2551 - 3999 (+) Exporter
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        • AFB35618.1
        • esmA1
        		 4154 - 4654 (+) AOCHC dimerization
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          • AFB35619.1
          • esmH1
          		 4703 - 5035 (+) Hypothetical
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            • AFB35620.1
            • esmA2
            		 5068 - 5703 (+) EsmA2
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              • AFB35621.1
              • esmB2
              		 5783 - 7204 (-) EsmB2
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                • AFB35623.1
                • esmB1
                		 7204 - 8301 (-) EsmB1
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                  • AFB35624.1
                  • esmT1
                  		 8314 - 9399 (-) EsmT1
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                    • AFB35622.1
                    • esmA3
                    		 9770 - 10507 (+) EsmA3
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                      • AFB35625.1
                      • esmT2
                      		 10563 - 13358 (+) EsmT2
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                        • AFB35626.1
                        • esmA5
                        		 13803 - 15731 (-) EsmA5
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                          • AFB35627.1
                          • esmA4
                          		 15728 - 16396 (-) EsmA4
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                            • AFB35628.1
                            • esmD3
                            		 16422 - 16673 (-) EsmD3
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                              • AFB35629.1
                              • esmD2
                              		 16712 - 18415 (-) EsmD2
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                                • AFB35630.1
                                • esmD1
                                		 18518 - 19555 (-) EsmD1
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                                  • AFB35631.1
                                  • esmA8
                                  		 19651 - 20187 (-) EsmA8
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                                    • AFB35632.1
                                    • esmA7
                                    		 20199 - 21383 (-) EsmA7
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                                      • AFB35633.1
                                      • esmA6
                                      		 21427 - 22842 (-) EsmA6
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                                        • AFB35634.1
                                        • esmB3
                                        		 23336 - 23743 (+) EsmB3
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                                          • AFB35635.1
                                          • esmB4
                                          		 23736 - 26510 (+) EsmB4
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                                            • AFB35636.1
                                            • esmB5
                                            		 26523 - 27314 (+) EsmB5
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                                              • AFB35637.1
                                              • esmC
                                              		 27311 - 28384 (+) EsmC
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                                                • AFB35638.1
                                                • esmH2
                                                		 28479 - 28916 (+) EsmH2
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                                                  • AFB35639.1
                                                  • esmT6
                                                  		 28885 - 29847 (-) EsmT6
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                                                    Biosynthesis information

                                                    Biosynthetic modules

                                                    Name
                                                    1
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    esmB4
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                    Annotation changelog

                                                    Entry version: next

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2024-03-19
                                                    MIBiG v4 annotathon
                                                    • (ID: YMNBNYWEKI2BEKVVGTVE6OUH)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 4

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2015-06-12
                                                    Submitted
                                                    • (ID: VQJTWYI3STDVOHG36EUY4LM4)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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