BGC0000935: esmeraldin biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 29,897 nt. (total: 29,897 nt).
This entry is originally from NCBI GenBank JF417969.1.

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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000935
Short description esmeraldin biosynthetic gene cluster from Streptomyces antibioticus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The esmeraldin biosynthetic gene cluster was identified on a dispensable giant plasmid."
Biosynthetic class(es)
  • Other (Aminocoumarin)
  • Polyketide
Loci NCBI GenBank: JF417969.1
Compounds
  • esmeraldin
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
esmeraldin
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C38H28N4O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFB35615.1
  • esmT3
 152 - 1624 (+) Integrin-like protein
  • Regulation
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  • AFB35616.1
  • esmT4
 1695 - 2423 (+) Transcriptional regulation
  • Regulation
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  • AFB35617.1
  • esmT5
 2551 - 3999 (+) Exporter
  • Transport
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  • AFB35618.1
  • esmA1
 4154 - 4654 (+) AOCHC dimerization
  • Scaffold biosynthesis
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  • AFB35619.1
  • esmH1
 4703 - 5035 (+) Hypothetical
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  • AFB35620.1
  • esmA2
 5068 - 5703 (+) PDC formation
  • Scaffold biosynthesis
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  • AFB35621.1
  • esmB2
 5783 - 7204 (-) Function with EsmB1
  • Scaffold biosynthesis
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  • AFB35623.1
  • esmB1
 7204 - 8301 (-) PDC adenylase
  • Scaffold biosynthesis
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  • AFB35624.1
  • esmT1
 8314 - 9399 (-) Transcriptional activation
  • Regulation
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  • AFB35622.1
  • esmA3
 9770 - 10507 (+) DHHA isomerase
  • Scaffold biosynthesis
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  • AFB35625.1
  • esmT2
 10563 - 13358 (+) Quorum sensing
  • Regulation
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  • AFB35626.1
  • esmA5
 13803 - 15731 (-) ADIC synthase
  • Scaffold biosynthesis
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  • AFB35627.1
  • esmA4
 15728 - 16396 (-) DHHA synthase
  • Scaffold biosynthesis
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  • AFB35628.1
  • esmD3
 16422 - 16673 (-) 6-methylsalicylyl carrier protein
  • Scaffold biosynthesis
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  • AFB35629.1
  • esmD2
 16712 - 18415 (-) 6-MSA adenylase
  • Scaffold biosynthesis
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  • AFB35630.1
  • esmD1
 18518 - 19555 (-) Esterification
  • Scaffold biosynthesis
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  • AFB35631.1
  • esmA8
 19651 - 20187 (-) Shikimate kinase
  • Scaffold biosynthesis
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  • AFB35632.1
  • esmA7
 20199 - 21383 (-) Chorismate synthase
  • Scaffold biosynthesis
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  • AFB35633.1
  • esmA6
 21427 - 22842 (-) DAHP synthase
  • Scaffold biosynthesis
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  • AFB35634.1
  • esmB3
 23336 - 23743 (+) PDC carrier protein
  • Scaffold biosynthesis
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  • AFB35635.1
  • esmB4
 23736 - 26510 (+) KS-AT-ACP
  • Scaffold biosynthesis
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  • AFB35636.1
  • esmB5
 26523 - 27314 (+) Thioesterase
  • Scaffold biosynthesis
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  • AFB35637.1
  • esmC
 27311 - 28384 (+) 6-acetyl-PCA reductase
  • Scaffold biosynthesis
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  • AFB35638.1
  • esmH2
 28479 - 28916 (+) Hypothetical
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  • AFB35639.1
  • esmT6
 28885 - 29847 (-) Transcriptional regulation
  • Regulation
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
esmB1
+
esmB4 		Synthase subclass:
Module 0
Genes: esmB1
Core domains: Adenlyation
Module 1
Specificity: Malonyl-CoA
Genes: esmB4
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: VQJTWYI3STDVOHG36EUY4LM4, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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