BGC0000935: Esmeraldin biosynthetic gene cluster from Streptomyces antibioticus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 29,897 nt. (total: 29,897 nt).
This entry is originally from NCBI GenBank JF417969.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
other genes
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000935
Short description Esmeraldin biosynthetic gene cluster from Streptomyces antibioticus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The esmeraldin biosynthetic gene cluster was identified on a dispensable giant plasmid."
Biosynthetic class(es)
  • Other (Aminocoumarin)
Loci NCBI GenBank: JF417969.1
Compounds
  • Esmeraldin
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
Copy SMILES
Esmeraldin
Molecular Formula C92N6O7
Chemical database entries PubCHEM  
List of genes involved in compound(s) production
Identifiers Position Product Functions Extra
  • AFB35615.1
  • esmT3
152 1624 + Integrin-like protein
  • Regulation (evidence: K)
copy AA seq
copy Nt seq
  • AFB35616.1
  • esmT4
1695 2423 + Transcriptional regulation
  • Regulation (evidence: K)
copy AA seq
copy Nt seq
  • AFB35617.1
  • esmT5
2551 3999 + Exporter
  • Transport (evidence: K)
copy AA seq
copy Nt seq
  • AFB35618.1
  • esmA1
4154 4654 + AOCHC dimerization
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35619.1
  • esmH1
4703 5035 + Hypothetical
copy AA seq
copy Nt seq
  • AFB35620.1
  • esmA2
5068 5703 + PDC formation
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35621.1
  • esmB2
5783 7204 - Function with EsmB1
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35623.1
  • esmB1
7204 8301 - PDC adenylase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35624.1
  • esmT1
8314 9399 - Transcriptional activation
  • Regulation (evidence: K)
copy AA seq
copy Nt seq
  • AFB35622.1
  • esmA3
9770 10507 + DHHA isomerase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35625.1
  • esmT2
10563 13358 + Quorum sensing
  • Regulation (evidence: K)
copy AA seq
copy Nt seq
  • AFB35626.1
  • esmA5
13803 15731 - ADIC synthase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35627.1
  • esmA4
15728 16396 - DHHA synthase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35628.1
  • esmD3
16422 16673 - 6-methylsalicylyl carrier protein
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35629.1
  • esmD2
16712 18415 - 6-MSA adenylase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35630.1
  • esmD1
18518 19555 - Esterification
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35631.1
  • esmA8
19651 20187 - Shikimate kinase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35632.1
  • esmA7
20199 21383 - Chorismate synthase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35633.1
  • esmA6
21427 22842 - DAHP synthase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35634.1
  • esmB3
23336 23743 + PDC carrier protein
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35635.1
  • esmB4
23736 26510 + KS-AT-ACP
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35636.1
  • esmB5
26523 27314 + Thioesterase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35637.1
  • esmC
27311 28384 + 6-acetyl-PCA reductase
  • Scaffold biosynthesis (evidence: K)
copy AA seq
copy Nt seq
  • AFB35638.1
  • esmH2
28479 28916 + Hypothetical
copy AA seq
copy Nt seq
  • AFB35639.1
  • esmT6
28885 29847 - Transcriptional regulation
  • Regulation (evidence: K)
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass
Cyclic? no
Polyketide-synthases
Genes Properties Modules
AFB35623.1
+
AFB35635.1
Synthase subclass:
Module 0
Specificity: Unknown
Evidence for specificity: ?
Genes: AFB35623.1
Core domains: Adenlyation
KR-domain stereochemistry: Unknown
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: ?
Genes: AFB35635.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Notes
2.0
  • Migrated from v1.4
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only