BGC0000938: fosfomycin biosynthetic gene cluster from Streptomyces fradiae
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Location: 1 - 31,799 nt. (total: 31,799 nt).
This entry is originally from NCBI GenBank EU924263.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000938
Short description fosfomycin biosynthetic gene cluster from Streptomyces fradiae
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Other (Aminocoumarin)
Loci NCBI GenBank: EU924263.1
Compounds
  • fosfomycin
Species Streptomyces fradiae [taxonomy]
References
Chemical products information
fosfomycin
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C3H7O4P1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACG70810.1
 105 - 1385 (+) putative membrane protein
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  • ACG70811.1
  • bioH
 1478 - 2260 (+) pimeloyl-CoA synthesis protein-like protein
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  • ACG70812.1
 2291 - 2788 (+) hypothetical protein
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  • ACG70813.1
  • fomR
 3250 - 4083 (+) transcriptional regulator
  • Regulation
Sequence-based prediction
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  • ACG70814.1
 4146 - 5405 (-) hypothetical protein
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  • ACG70815.1
 5380 - 6471 (-) mandelate racemase-like protein
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  • ACG70816.1
 6547 - 7224 (-) demethylmenaquinone methyltransferase-like protein
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  • ACG70817.1
 7221 - 8570 (-) hypothetical protein
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  • ACG70818.1
 8545 - 9483 (-) branched-chain amino acid aminotransferase-like protein
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  • ACG70819.1
 9470 - 10237 (-) putative coenzyme PQQ synthesis protein c
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  • ACG70820.1
 10239 - 11240 (-) HMG-CoA lyase-like protein
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  • ACG70821.1
 11575 - 12339 (-) succinyl-diaminopimelate desuccinylase-like protein
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  • ACG70822.1
 12336 - 13658 (-) Unknown
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  • ACG70823.1
 13682 - 15001 (-) putative antibiotic transport protein
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  • ACG70824.1
  • fomF
 15002 - 16411 (-) fomF
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  • ACG70825.1
  • fomE
 16408 - 17094 (-) fomE
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  • ACG70826.1
  • fom3
 17478 - 19082 (+) SAM-dependent methyltransferase
  • Other enzymatic
Sequence-based prediction
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  • ACG70827.1
  • fom4
 19099 - 19695 (+) epoxidase
  • Other enzymatic
Activity assay
Sequence-based prediction
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  • ACG70828.1
  • fomD
 19790 - 20413 (+) fomD
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  • ACG70829.1
  • fomA
 20417 - 21217 (+) kinase
  • Resistance/immunity
Activity assay
Sequence-based prediction
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  • ACG70830.1
  • fomB
 21230 - 22222 (+) fomB
  • Resistance/immunity
Activity assay
Sequence-based prediction
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  • ACG70831.1
  • fom1
 22254 - 23561 (+) phosphoenolpyruvate phosphomutase
  • Other enzymatic
Activity assay
Sequence-based prediction
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  • ACG70832.1
  • fom2
 23558 - 24712 (+) phosphonopyruvate decarboxylase
  • Other enzymatic
Activity assay
Sequence-based prediction
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  • ACG70833.1
  • fomC
 24709 - 25857 (+) group III metal-dependent alcohol dehydrogenase
  • Other enzymatic
Activity assay
Sequence-based prediction
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  • ACG70834.1
 25841 - 26767 (-) putative dienelactone hydrolase
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  • ACG70835.1
 26910 - 27644 (+) putative transcriptional regulator
  • Regulation
Sequence-based prediction
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  • ACG70836.1
  • phnD
 27739 - 28707 (+) phosphonate-binding periplasmic protein
  • Transport
Sequence-based prediction
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  • ACG70837.1
  • phnC
 28745 - 29542 (+) ATP-binding phosphonate ABC transporter PhnC
  • Transport
Sequence-based prediction
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  • ACG70838.1
  • phnE
 29539 - 31263 (+) ABC-type phosphonate permease
  • Transport
Sequence-based prediction
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZMZXFLPDGFEHMQPX76IB4OQ3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: H5KVDLSVQ3TJW7SKCDNBDEVC, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for fosfomycin
  • Removed gene names of 'No gene ID'
  • Removed duplicate gene names
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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