Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000938.1:
Cluster 1Other131799

BGC0000938, fosfomycin biosynthetic gene cluster from Streptomyces fradiae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Fosfomycin
PubChem ID: 73491
SMILES string: Copy to clipboard
Molecular formula: C3H5Na2O4P
Average molecular mass: 182.022 Da
Molecular activity: Antibacterial, Inhibitor
Molecular target: UDP-GlcNAc enolpyruvyltransferase (MurA)

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Aminocoumarin

Gene cluster description

fosfomycin (BGC0000938). Gene Cluster 1. Biosynthetic class = Other. GenBank EU924263. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Wilfred Van Der Donk (University of Illinois at Urbana-Champaign)

Literature references

1. Woodyer RD et al. (2006) Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol 13(11):1171-82. doi: 10.1016/j.chembiol.2006.09.007.
2. Woodyer RD et al. (2007) New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (4):359-61. doi: 10.1039/b614678c. Epub 2006 Nov
3. Kahan FM et al. (1974) The mechanism of action of fosfomycin (phosphonomycin). Ann N Y Acad Sci 235(0):364-86.