BGC0000938: fosfomycin biosynthetic gene cluster from Streptomyces fradiae
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Location: 1 - 31,799 nt. (total: 31,799 nt).
This entry is originally from NCBI GenBank EU924263.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000938
Short description fosfomycin biosynthetic gene cluster from Streptomyces fradiae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (aminocoumarin)
Loci
EU924263.1
via Heterologous expression
Compounds
  • fosfomycin
Species Streptomyces fradiae [taxonomy]
References
Chemical products information
fosfomycin Evidence: NMR [1]
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C3H7O4P1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACG70810.1
 105 - 1385 (+) putative membrane protein
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    • ACG70811.1
    • bioH
    		 1478 - 2260 (+) pimeloyl-CoA synthesis protein-like protein
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      • ACG70812.1
      		 2291 - 2788 (+) hypothetical protein
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        • ACG70813.1
        • fomR
        		 3250 - 4083 (+) transcriptional regulator
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          • ACG70814.1
          		 4146 - 5405 (-) hypothetical protein
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            • ACG70815.1
            		 5380 - 6471 (-) mandelate racemase-like protein
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              • ACG70816.1
              		 6547 - 7224 (-) demethylmenaquinone methyltransferase-like protein
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                • ACG70817.1
                		 7221 - 8570 (-) hypothetical protein
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                  • ACG70818.1
                  		 8545 - 9483 (-) branched-chain amino acid aminotransferase-like protein
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                    • ACG70819.1
                    		 9470 - 10237 (-) putative coenzyme PQQ synthesis protein c
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                      • ACG70820.1
                      		 10239 - 11240 (-) HMG-CoA lyase-like protein
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                        • ACG70821.1
                        		 11575 - 12339 (-) succinyl-diaminopimelate desuccinylase-like protein
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                          • ACG70822.1
                          		 12336 - 13658 (-) unknown
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                            • ACG70823.1
                            		 13682 - 15001 (-) putative antibiotic transport protein
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                              • ACG70824.1
                              • fomF
                              		 15002 - 16411 (-) FomF
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                                • ACG70825.1
                                • fomE
                                		 16408 - 17094 (-) FomE
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                                  • ACG70826.1
                                  • fom3
                                  		 17478 - 19082 (+) SAM-dependent methyltransferase
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                                    • ACG70827.1
                                    • fom4
                                    		 19099 - 19695 (+) epoxidase
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                                      • ACG70828.1
                                      • fomD
                                      		 19790 - 20413 (+) FomD
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                                        • ACG70829.1
                                        • fomA
                                        		 20417 - 21217 (+) kinase
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                                          • ACG70830.1
                                          • fomB
                                          		 21230 - 22222 (+) FomB
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                                            • ACG70831.1
                                            • fom1
                                            		 22254 - 23561 (+) phosphoenolpyruvate phosphomutase
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                                              • ACG70832.1
                                              • fom2
                                              		 23558 - 24712 (+) phosphonopyruvate decarboxylase
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                                                • ACG70833.1
                                                • fomC
                                                		 24709 - 25857 (+) group III metal-dependent alcohol dehydrogenase
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                                                  • ACG70834.1
                                                  		 25841 - 26767 (-) putative dienelactone hydrolase
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                                                    • ACG70835.1
                                                    		 26910 - 27644 (+) putative transcriptional regulator
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                                                      • ACG70836.1
                                                      • phnD
                                                      		 27739 - 28707 (+) phosphonate-binding periplasmic protein
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                                                        • ACG70837.1
                                                        • phnC
                                                        		 28745 - 29542 (+) ATP-binding phosphonate ABC transporter PhnC
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                                                          • ACG70838.1
                                                          • phnE
                                                          		 29539 - 31263 (+) ABC-type phosphonate permease
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                                                            Biosynthesis information
                                                            Annotation changelog

                                                            Entry version: next

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2024-05-02
                                                            MIBiG v4 annotathon
                                                            • (ID: EMAUK5TYS6O5PLPCDCIRFTNF)
                                                            • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Update compound structure (SMILES) for fosfomycin
                                                            • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Removed gene names of 'No gene ID'
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Removed duplicate gene names
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: ZMZXFLPDGFEHMQPX76IB4OQ3)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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