LOCUS       BGC0000939             16366 bp    DNA     linear   BCT 20-DEC-2011
DEFINITION  Grimontia hollisae gene cluster for aerobactin-mediated iron
            acqusition (hatC, hatD, hatB, iucA, iucB, iucC, iucD, iutA),
            complete cds.
ACCESSION   BGC0000939
VERSION     BGC0000939
KEYWORDS    .
SOURCE      Grimontia hollisae
  ORGANISM  Grimontia hollisae
            Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
            Vibrionaceae; Grimontia.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 21:07:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16366
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..16366
                     /db_xref="taxon:673"
                     /mol_type="genomic DNA"
                     /note="synonym: Vibrio hollisae"
                     /organism="Grimontia hollisae"
                     /strain="ATCC 33564"
                     /type_material="type strain of Grimontia hollisae"
     subregion       1..16366
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..16366
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(1835..3043)
                     /codon_start=1
                     /function="unknown"
                     /note="similar to ShiF protein"
                     /product="hypothetical protein"
                     /protein_id="BAE15998.1"
                     /transl_table=11
                     /translation="MRTPLSKNQERKGVKASATVIASIAALMGLGQGGLLVSLPVLVSE
                     TQLSLTVWSIVIATGSVFFLPASPYWGRQSDLNGPKPIVLQALVGFGMSFGLLYVFIRF
                     TNTSNLPDAWVIAGLVTARIVYGLTVAGMVPAAQHWAVLLKGEEKRLEAITTISAGMST
                     GRLLGPLLAIALLNIHPLAPLITLTMLPFIGLLIVKSLPDPGRQTHTQTKPSAPVLPPW
                     RAVPFLFIAMLGSAALALMQYTLTPMLQVATEWSVSDISNAVGMLLTVSAAITLTTQIL
                     VIKRQRLSARRMLVAGAVLMLSGYTLFLSLHWPVLVLAVGLVAAGGALFVPAYVSEATS
                     RTVAQQGTMAGYIAMSHTLGYGLSALLVMSLAFGVVIPIGINITLSGIILFVSVVLYLK
                     PRQ"
     gene            3163..3930
                     /gene="hatC"
     CDS             3163..3930
                     /codon_start=1
                     /gene="hatC"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 205.8; E-value:
                     1.3e-62)"
                     /gene_kind="transport"
                     /product="ATP-binding protein"
                     /protein_id="BAE15999.1"
                     /transl_table=11
                     /translation="MFSLNAVSYSVPEKTILHPVSLTIPAGRITTLLGHNGSGKSTLIK
                     LLSRNILPSSGDIQLAGMPLSAFSSRDYSRRVAYLPQDPPITDSITVYELVRLGRYPWK
                     GALGRYDEHDDDIIAQAMNAVGVSTLADRFVSTLSGGERQRVWVAMLLAQQSECLLLDE
                     PTSALDVAHQYELLSLIRKLNRERNLTVVMVLHDINLAARYSDTLVALHSGKIMAQGDA
                     QSLMSQPILEAIYDIPLGFFPHPENGQPIAYVR"
     gene            3956..4855
                     /gene="hatD"
     CDS             3956..4855
                     /codon_start=1
                     /gene="hatD"
                     /gene_functions="transport (smcogs) SMCOG1033:iron compound
                     ABC transporter, periplasmic (Score: 204.2; E-value:
                     3.6e-62)"
                     /gene_kind="transport"
                     /product="periplasmic binding protein"
                     /protein_id="BAE16000.1"
                     /transl_table=11
                     /translation="MRRVVCLSLFFFSHAFALTVKHDLGETEIPNIPQRVVALDWVSTE
                     TLLSLGITPFAIADTDGYRHWVAFPALPDTVKDVGSRREPNLESITALKPDLIVINEAH
                     AAVYPALAKIAPTVAFNVFNGEKKPLKALRTMTVTVGSIFGKEDVSHDVINAAQHIFQQ
                     NNAKLHEAGMANLPLVVIRFIGNTHVRIHGEGSLANDIVVELGLRNSWQEKTNNWGFSS
                     SGIEALAKHQQATVVYLESLDDAQRKAIFSTPLWKAMRFSRENNVIALPPIWTFGGLIS
                     AQRMSNEITANLIGNAEK"
     gene            4852..6843
                     /gene="hatB"
     CDS             4852..6843
                     /codon_start=1
                     /gene="hatB"
                     /gene_functions="transport (smcogs) SMCOG1011:transport
                     system permease protein (Score: 230.4; E-value: 4.6e-70)"
                     /gene_kind="transport"
                     /product="membrane permease"
                     /protein_id="BAE16001.1"
                     /transl_table=11
                     /translation="MNTLPYPNPANHPYRVTGMVVTILSLILLLIYTSAPYPLTATDWL
                     GAILSPDEEDYRQIIIHYSYLPRLAMAILCGAALAIAGCVMRFVLNNPLASPTTLGVAA
                     GAELGLVTGTLFFSATAGLSLYLSAFTGGLLATLLVFAITPRQSYSPLSLILSGMVTTL
                     FIGAVTMMLVLVNEQTLTHLFLWGAGALEQNDWQGVTRLLPFLIVPVLLLTGISRALSL
                     LQLGDTVAGSLGAKVVRVRLAALTLSVVMTASVVSEVGIIGFVGLVSPAIARILGARRL
                     PGQIALSACIGALLLLGADLLVQNLSHWVADVIPTGAVTALLGAPFMLYLLQRRLLGSA
                     LSSANTMHQPGKRLPFKPLALLLVLFFVFTVSVSMTWGQSDAGWVFGIDPALLSLRGFR
                     IAVAALAGASLAMAGCVIQRLTGNPMASPEVLGISAGCALAIVLAAAFGLALSRLEQLL
                     FGALGAVAVMALILWFSRKKTASPTHFILIGIAISAMADAIIRLTMASGQEGVKSLLSW
                     LSGSLYLADTMAVGLLIITLILFGSFTVAFSRWLDVINLGDTVSESLGLSVKATRKVLI
                     VIAAIMTSAATIAIGPLSFIGLLAPHMATSLGQHSARQQLMIAPILGAILLVMADWVGR
                     NLWFPWQFPAGLLASIIGAAYFLNLLRR"
     gene            6980..8812
                     /gene="iucA"
     CDS             6980..8812
                     /codon_start=1
                     /gene="iucA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /product="aerobactin synthetase"
                     /protein_id="BAE16002.1"
                     /sec_met_domain="IucA_IucC (E-value: 8.7e-59, bitscore:
                     188.2, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDQQHCYGLKGSDVAIACFLNAFLRECPKVGAKKTGEDHYQLQI
                     PVNDHYHIAYQISKYSTLGLHEYKMPAYLVTKDRATPLSFSDVLFKVVSEPALVGNLTE
                     QQKNAFVARVLESQRNTHNAITHQPNLEALFSTTLRFEQAEQGLLAGHSVHPAPKSREQ
                     FSQHDAKRYSPEFGGKFPLRWFAVAKWLTLSHYTGEDLGKEARESNGQNAPHHPVNALA
                     DADMALSEAARAIPDGFALFPAHPWQAEVLLKHPDIKNYQSRGLLLDLGEMGQYWYPLL
                     PPVPFTAPVCFPAEILLECKLTNSIRTLSLKEVMRGTRLNQIFQSAGFAQVDAALPDGF
                     EVMQEPGFLALLDTHGNVIDESLVALRDNLLAKTPDEEAVVLATLCQQHPFGRDSLLAA
                     RVKQLAAHLATTPENAAIKWFDNYCHQVVGSLFSLQGNGGIVCLAHQQNIVMRLQDGMP
                     VGMYYRDCQGTGYTDLAYTLFPDILIDDTQDLENHWEQEKVLRYFPYYLIINSTFSVIA
                     SLSLHCGVSEGALLERLRAYLKSLKGKLVDTHCLNYVLESPALCCKGNFYCYLQDLNEN
                     AIPDPKVIYFDLPNPLVCHATDNRPSSEKEAHYV"
     gene            8805..9743
                     /gene="iucB"
     CDS             8805..9743
                     /codon_start=1
                     /gene="iucB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     282.8; E-value: 8.1e-86)"
                     /gene_kind="biosynthetic-additional"
                     /product="N6-hydroxylysine acetyltransferase"
                     /protein_id="BAE16003.1"
                     /transl_table=11
                     /translation="MSDCQLSLSPTTDKHHLDDIFPLLEPEMLIAAGEKNSGDSLASAL
                     DHYFCVNPKSPAVQLPRERWNSHIAPSHWLYMFLDDVLTRSQFNQLPATGLCHMPTDRY
                     PALPVQSTKQSGFHPKRPASPKGYVYQRTDPLNGITVSYRLFEPEKDMPRFTRWMNCPR
                     VADFWEQAWSEEALLDYINGRLSDPHTLPLIGEFDGQPFGYIEAYWVSEDRLAPYYDSQ
                     PFDRGIHVLVGEEAFRGERYFNMWMRAITHYLFLDDCRTMRVVLEPRYDNTRLFNRIKS
                     VGYKQKFLFDFPHKRAALMMTSRYAFFREQW"
     gene            9743..11503
                     /gene="iucC"
     CDS             9743..11503
                     /codon_start=1
                     /gene="iucC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /product="aerobactin synthetase"
                     /protein_id="BAE16004.1"
                     /sec_met_domain="IucA_IucC (E-value: 3.4e-75, bitscore:
                     242.0, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQNALHRFWPAANRALVAKLISELEYEQAFKLEPVGQEHCLTLP
                     AGVRYRVKGKRNIWGQLNILPGSIRREDNGEHNLPVEASRFMLDCKTVLGLDDDTLAEH
                     LEDLYATLLGDCKLMQLREHLDADAFARLSLEKQQCLFDGHPKFVFNKGRRAWGSEDLR
                     HFAPESEEPFQLCWIAVNHTLVTGAISEYLNWNHLYQNALSDDDLASVRCDLEMLGLNP
                     ANFLLLPVHPWQWDNKLSLLFVAELARKEMVYLGTFGDAFLPQLSLRTLTNVSRPARYD
                     IKLPLTIMNTSCYRGMPSRYIQAGPQASAWLENTVKSDPLFISLGTDVLQEPAGLTVSH
                     TVYDSLEKAPYRYHELCGAIWRESASTKTRPGEQAILMAALMESDSAGNPLIGAYIRAS
                     GLSAKDWLSQLFRAVVIPYYHLLAKYGVSLIAHGQNVTLVLENSTPKRILLKDFQGDMR
                     LMQGDIPEQDSLPQAVKDVTVTLPPDLIIHDLQTGHFVTVLRFISPLAEKTGVSEHRFY
                     KLLAQELQAYMQSHPELEARIQLLDLFRPKIRRLGLNLAKFRHATENSADRMLPQMEHF
                     IDNPLYLVTH"
     gene            11517..12827
                     /gene="iucD"
     CDS             11517..12827
                     /codon_start=1
                     /gene="iucD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 379.1;
                     E-value: 4e-115)"
                     /gene_kind="biosynthetic-additional"
                     /product="lysine N6-monooxygenase"
                     /protein_id="BAE16005.1"
                     /transl_table=11
                     /translation="MTTTISSQVLDLAGIGAGPFNLSVAALLQQVPETKYCFFESRDSV
                     SWHPGMLLDDTHMQTTFLKDLVTPVFPQSPYSFLAYLVEKKRIYRFLTAELGCISRTEF
                     SDYLYWASEKLPNIAFSTCVEKIEFADGVFHIHTDKGTTLARNLCLGTGKSPHVPECMK
                     PYIGEHIFHAAEIALSPRDFTGKRVAIIGGGQSGADVFINALRGTWGKFAKLDWVSRRP
                     NYQPLDEAAFTNEYFTPDYVEAFLTLSPDVKAREVSMQKLTSDGVTQKALLEIYRELYQ
                     RFDVNNEEKWVRLLPHRTVTQLLSHKGGYELFLENGLANQLERLDADIIILATGYESRT
                     PRCLDGLRPLINADSEGRFQLNQYFEVEWAHSDTNRIFAVNVGMHSHGIAEPQLSLMAW
                     RSAQIINRLCQKPVFNTEAGPALIEWISPTSLVEAFA"
     gene            13704..15938
                     /gene="iutA"
     CDS             13704..15938
                     /codon_start=1
                     /gene="iutA"
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 172; E-value: 4.9e-52)"
                     /gene_kind="transport"
                     /product="ferric aerobactin receptor"
                     /protein_id="BAE16006.1"
                     /transl_table=11
                     /translation="MKLSRTFITNPFTLAICAAITTQSPVVSASTDTEGRAPLDTVVIT
                     GRSEKVISDIAGTVWVVDSEQIEQQYRGGKNLSEILASAVPALDVSSQGRTNFGQNMRG
                     RPMLVMIDGVSLNSSRSVSRQLDAIDPFNIASIEVLSGASSIYGAGATGGIINIVTFRA
                     DASELAFESYAGATSGFNGGEDFDYKIAQSVSGGNDKVKGRVSVVYGENKGAFDADGNI
                     NVPDITQGSLQFNEVVDVLGTLNITPDSAQSIQLLAQYYSSKQDSPYGIYFGENLAGAP
                     NNITGNPADTSLIETRKGFSSDRQGGTERLMLNANYHHNNVLGQDLFLQASFRREEFSF
                     IPFIYGSYLAASEQNTDVLTLRAAMVKSMDNLTLTYGIDSYLDKLTSNQALFDRNLSYQ
                     SGGLINRTEAKIGRYPGTEVASVAGFVQADYQLTDDWSLSGGYRYQWMQNTIDDFVAAS
                     VQQQIAQGNGTSADAVPGGSTDYTIGLFNLGTVYKLSKNAQIWANFSQGFDLADPAKYY
                     GQGNYSAPDANGHHTLTDSINVSSSKMQGIKTNSVEIGARQYLDALSWQAAAYISESDK
                     TLKYNRQTLNIDVNDAKKRIYGIEAEVAYWLTDNLQTGLTGHWVDSEEQDSEGKWSKMS
                     VNYASASKAGAWLGWYEDNYSVRLQNQTLFDLSDENNGKIDGYSLFDLIGTVELPKGRL
                     GFGIQNLLNEDYTTVWGQRAKGWYSYYGPEEMFDYRGRGRTYTLNYSLSY"
ORIGIN
        1 atcgatgaca tcgtcgactt actcgctatc gtgcaagacg acaacggcta cctcaatacg
       61 tatttcacca tcaaagagcc agagaatcgc tggaaagacc tgtgtgaatg ccacgagttg
      121 tattgcgcgg ggcatttgtt tgaggcggca gtggcttact atcaagcgac aggcaaagat
      181 aagctactta acatctcttg caagtttgcc gaccatatag ccgacacttt tggtcctgaa
      241 gaagaccaaa tacaaggcta tccaggtcac ccagaaatag aactggcgtt gatgcgtcta
      301 tacgaagtga caggcaacca acgttactct gatctggcaa acttctttat tgagcagcgc
      361 ggcaaagaac aaaacccgca tttctatgat caagaacaag ccaaacgtga tggtagttat
      421 cattacaacg accacggtcc gtcatggatg atcaaagaca aaacctacag ccaagcgcat
      481 aagcatttaa gcgaacaaaa agaggcgatt ggccacgcag ttcgcttcgt ttacttactg
      541 gcgggggtgg cgcatctggc gcgattgtcg aaagaccaag agaagttcag ttggtgtaag
      601 gacctgtggc gtaacgtcat cgacaaacag atgtacatta ctggcgcgat tggttctcaa
      661 agccgcggag aagcgttcac taccgactat gacttaccaa acgacaccgc atataccgag
      721 acctgtgcat cggtaggttt gctgatgttt gccaaccgta tgctgcaaat cgagagcgac
      781 ggcgagtacg gcgacatcat ggaacgcgcg ctgtacaaca ccatccttgc gggtatggcg
      841 ttagacggaa agcacttctt ctacgtcaat ccactggaag tcacgccgaa agtgattcat
      901 gcaaaccata agtatgatca cgtcaaaccg gtacgtcagg catggtttgg ctgttcatgc
      961 tgcccaacca acgtcgctcg tacactggcg tctttgggtc agtacatttt caccgtcaaa
     1021 gaagatgtgg cgctgttgaa cctgtttatc tccaatgaag ccaaactgga gctaaaccag
     1081 caacccatca cgctgagtat tgatgccaat atcccacaaa gcgataaagt gtcgataaac
     1141 gtgaaagacg ccaatcaggt caacggtacg attgcggtgc gcattccaag ctggtgcgcc
     1201 aatatgagcg cgacgttaat tggcaaagcc atcgacgtca acgccgacag taaacgtggg
     1261 tatctataca tcaccaacac ttggaatacc ggtgataaga ttgaagtgac gctacccatg
     1321 gaagcgttct ttatccaagc gaaccctctg ctaagcgcca actttggtaa agtcgccgtg
     1381 cagcgtgggc ctttcgttta ctgtatcgaa caagcagaca acggcgaagc gttacacact
     1441 attaaggttg acgccaaatc tggtctaaaa gaagttgatg gcgaagggtt gtttgccggc
     1501 agcgtattgc taaaagcaag tggatctaaa gtggtcattc aagacgcgcc tcatcaagcg
     1561 ttatatcacc aatatccata cacgccgcaa gagaaaacct gcgatatcac cttgataccg
     1621 tactacgcgt gggcaaatcg aggggaaggt gaaatgcgag tttggataaa cgaaaaataa
     1681 ctggctaaca tcaacgccaa aagacactct ggagtaatgc ctatcagtaa agccgccagc
     1741 gcagacggaa agttgcgctg gtggctttaa attcacttag tatgaggata agcaccggag
     1801 atatcaccca atatacgcgg catttaaaca aacattattg tcttggcttt aagtacaaca
     1861 ctacagaaac gaagagaatt attccgctca gggtaatatt tattcctata gggataacaa
     1921 ccccaaaagc caggctcatg accagcaacg cgctcagccc ataccccagg gtatgggaca
     1981 ttgcaatata ccccgccatt gtgccttgtt gggcgaccgt gcgggatgtt gcttcagaga
     2041 cataagcggg tacgaataac gctccaccag cagcaaccag acccactgcc agaaccagca
     2101 ctggccaatg caggctaaga aacaaggtgt agccagacag catcaacacg gcaccagcca
     2161 ctagcatccg gcgggctgaa aggcgttggc gttttatcac cagtatctgt gtcgtcaacg
     2221 ttatcgctgc acttactgtc aacagcatcc cgactgcgtt tgaaatatca gaaactgacc
     2281 actcggttgc cacttgcaac atgggggtaa gcgtatattg catcagcgca agggctgcgc
     2341 ttccaagcat cgcgataaac aaaaacggaa cggctcgcca aggcggtaaa actggcgcag
     2401 acggttttgt ctgtgtgtgg gtttgtcttc ccggatctgg caggcttttt acaatcaaca
     2461 acccaataaa aggcaacatc gtcagcgtga taagtggcgc taagggatgg atgtttaata
     2521 atgcaatcgc aagcagcggc ccaagcagcc gtccggtgct catcccggca ctgatggtgg
     2581 tgatcgcttc cagacgtttt tcttcccctt ttaacaacac cgcccaatgc tgcgccgcgg
     2641 gcaccattcc cgccacagtc agcccataca caatccgggc cgtaactaat cctgctatca
     2701 cccaggcatc tggaaggttt gatgtgtttg tgaaacggat aaagacatac agcaagccga
     2761 agctcatgcc aaaccccacc aacgcctgta acacaatcgg tttggggcca ttgaggtcac
     2821 tttgtcgccc ccaataaggg gaggcgggta ggaaaaacac actccctgtg gctatcacaa
     2881 tgctccagac agtcaggctc agttgcgttt ctgacactaa aacgggcaaa gagaccaata
     2941 atccgccctg ccctaatccc atcagcgcag caatactggc gatcaccgtg gctgaggctt
     3001 taaccccctt cctctcttgg tttttcgata acggtgtacg cataacatcg ctcaaacaat
     3061 cttttacatt gggtgacata tgatttaaat acaaatacaa tacacatgca aatcattatc
     3121 atttagattg gaaatcgtat tattccagat ggacgcactt ctatgttttc acttaacgcg
     3181 gtcagttatt cggtgccaga gaaaaccatt cttcacccgg tgtcactcac catcccggcg
     3241 ggaaggatta ccacactgct tggccacaac ggcagcggga aatcgacact gattaagcta
     3301 ttaagccgca acatattgcc ctccagtggc gacattcagc tggcaggtat gccattgagt
     3361 gcgttttctt cccgggacta ctcacgccgc gtcgcgtatt taccccaaga tccccctatc
     3421 acagacagca ttaccgtgta tgagttggtc aggcttggtc gctatccgtg gaaaggagca
     3481 ctcggcaggt acgacgaaca tgacgacgac attattgctc aagcgatgaa tgcggtgggt
     3541 gtcagcacct tggctgatcg gtttgtcagc acgctctcag gcggtgaacg ccagcgcgtc
     3601 tgggttgcca tgcttctcgc ccagcaaagc gaatgcctct tactcgacga gccaacctca
     3661 gcgctggatg tcgcccacca atatgaattg ctgtcactga taagaaagct caaccgggaa
     3721 cgtaacctaa ccgtcgttat ggtcttacac gacatcaacc tcgccgcccg ctacagcgac
     3781 acacttgttg ccttgcatag cggaaaaatc atggcgcaag gcgatgccca atccctgatg
     3841 agccaaccca tactcgaagc aatctatgac atccccctcg gcttttttcc ccatcctgaa
     3901 aatggccaac cgattgctta tgtccggtaa cccccactgt caatggagcg acattgtgag
     3961 acgcgttgtt tgcctatctt tattcttttt ttcccatgct tttgcgctca ccgttaaaca
     4021 tgaccttggt gagacagaaa tacccaacat accgcaacgg gtcgtcgccc ttgactgggt
     4081 aagtacagaa accctgctgt cgctcggcat cacacccttt gctatcgcag atacagacgg
     4141 ttaccggcat tgggtcgcgt ttcctgcctt gccggataca gtgaaagatg tcggttcacg
     4201 ccgcgagccg aatctggagt ccattacggc gttgaaaccc gatctcattg tgattaacga
     4261 agctcatgcc gccgtctatc cggcactggc aaagatagcc ccaacagtgg cattcaacgt
     4321 ctttaacgga gaaaagaaac ccttaaaagc actgagaacc atgacagtaa cggtgggaag
     4381 tatttttggc aaagaagacg tttcccacga cgtcatcaat gcagcacagc acatttttca
     4441 gcaaaataac gccaaactcc acgaagccgg tatggcaaac ctgcccctgg ttgttatccg
     4501 ctttatcggc aacactcatg tgcggatcca cggcgaaggt tcgctcgcca atgacattgt
     4561 tgttgagctc gggctaagga acagttggca ggaaaagacc aacaactggg gcttttcatc
     4621 atcagggatt gaggcactgg caaagcacca acaagcaaca gtggtgtatc tggagtcctt
     4681 ggatgacgcg cagagaaagg ccattttctc aacaccgctc tggaaagcca tgcgttttag
     4741 ccgggaaaac aacgtcattg cccttccccc aatctggacg tttggcggct tgatctcagc
     4801 ccagcggatg agcaatgaga tcacagcaaa cctgattggg aatgctgaga aatgaatacc
     4861 cttccctatc caaaccctgc caatcatcca tatcgcgtga caggaatggt agtgacgatc
     4921 ctttcactga ttcttctgct tatttacacc agcgcgccct atccccttac cgcaacagac
     4981 tggctgggcg ccattctgtc acccgacgaa gaagattacc ggcaaatcat catccactac
     5041 agttacctgc cacgtctggc aatggcgata ctatgtggtg cagcgttggc gatagccggt
     5101 tgcgtcatgc gctttgtgct caataaccct ctggcttccc ccaccacact gggcgtcgcc
     5161 gctggcgcgg agcttgggct ggtcacggga acactttttt tctctgccac ggcggggtta
     5221 agcctttatc tctctgcgtt cactggtggg ttgctcgcca ccttgctggt atttgcaatc
     5281 actccccgac aatcctattc accgctgtcc cttattctgt ccggcatggt gacaaccttg
     5341 tttattggtg ctgtgaccat gatgctggtg ttggtcaacg agcagacatt aacccacctt
     5401 ttcctatggg gcgcgggagc actggaacaa aatgactggc aaggcgtaac acgcctgttg
     5461 ccgtttttga ttgtcccagt gctcttactc accggaataa gccgcgcgct ctctttgctg
     5521 caattgggcg atactgttgc gggttcgctg ggcgcaaaag tggtgcgcgt gcggttggct
     5581 gcattaacgc tgtccgtcgt gatgaccgct tctgttgtca gcgaagtggg catcatcggc
     5641 ttcgtcggtc tggtatcacc ggcaatagca cgaatacttg gcgcacggcg tttgccgggc
     5701 cagatagcac tgtcggcatg catcggcgca ctgctgttgc ttggcgcaga tctgttagtg
     5761 caaaatctct cgcactgggt ggcagatgtg atccctaccg gtgcggtcac cgcgcttttg
     5821 ggcgcaccat ttatgctgta tctacttcag cgccggttgt tgggaagtgc cctttcctct
     5881 gcaaacacaa tgcatcagcc aggtaaacga ctccctttca aacctctggc gcttttgttg
     5941 gttctgtttt ttgttttcac ggtgtcagtg agcatgacat ggggacaatc agacgctggg
     6001 tgggtgttcg gcatcgatcc ggctttgctt tccctgcgtg ggtttcgcat cgccgttgct
     6061 gcattggctg gcgccagcct tgccatggcc ggttgtgtga tacagcgcct taccggtaac
     6121 cccatggcga gcccggaggt tttagggatc agtgcaggat gtgccctggc gattgttctg
     6181 gctgccgcat tcggcctcgc actgtcacgg ctggaacaac tgttgtttgg cgcacttggc
     6241 gctgttgccg tcatggcatt gattctctgg tttagccgaa agaaaaccgc ctcccctacc
     6301 cactttatcc tgattggcat tgcgataagc gcaatggcgg atgccatcat ccggctgacg
     6361 atggcatcgg gtcaggaagg cgtaaaatcg ctgctgagtt ggctgtctgg gtcactgtat
     6421 ctggctgata cgatggcggt gggtctattg attatcaccc ttatcctgtt tggcagtttc
     6481 accgtagctt tctcgcgctg gctggatgta atcaaccttg gcgacacagt gtcagaaagc
     6541 cttgggttgt ccgtcaaggc cacaagaaaa gtgcttattg tgatcgccgc catcatgaca
     6601 tcagccgcaa ccattgccat tgggccgctc agttttattg gtttactcgc gccacatatg
     6661 gcgacatcgc tcggtcagca cagcgccaga caacagctta tgattgcccc gatactggga
     6721 gcgatactgt tggtgatggc tgattgggta ggcagaaacc tttggtttcc ctggcaattt
     6781 ccggctggat tgctggcctc catcattggt gcagcctact ttctgaattt actccggcgt
     6841 tgacatcaaa ccagcccggc ctgagtcggg ctgcgtcctc cgcgttaaac ctcgcataaa
     6901 aaatgtgcga caaagccatt gcatgatcaa ataataatca ttatcattct caaaagaatc
     6961 gatagatgag aatgtgaaga tggaagatca acaacattgc tatggattga aaggctcaga
     7021 tgtcgcgatt gcctgctttc taaatgcctt cttgcgcgaa tgccctaagg ttggggcgaa
     7081 aaaaactggc gaagatcatt accagcttca gattccggtt aacgaccatt accatatcgc
     7141 ctatcagatc agcaaatact caacattagg cctccacgaa tacaaaatgc ctgcctatct
     7201 ggtcaccaag gatagggcta cacctctctc cttttcggat gttctgttca aggtggtatc
     7261 tgaaccggca ctggttggca acctgacgga acaacaaaaa aatgcctttg ttgcacgggt
     7321 attggagagc cagagaaata cacacaatgc catcacccat cagccaaatc tggaggctct
     7381 gttcagcact actttacgat tcgaacaagc cgagcagggg ttacttgccg gccactcagt
     7441 gcatcccgcg cccaaaagcc gcgagcaatt ttcacagcat gacgccaaac gctactcgcc
     7501 agagtttggt gggaaattcc ccttgcgctg gtttgcggtc gcgaaatggc tgaccctgag
     7561 ccactatact ggggaagatc tcgggaaaga ggccagagaa agcaacggac aaaacgctcc
     7621 ccatcaccct gtcaatgcgc tggccgatgc cgacatggca ctcagcgaag ccgcccgcgc
     7681 tatccccgac ggtttcgcgc ttttccccgc gcacccctgg caagccgaag tgttgttgaa
     7741 gcatccggat atcaaaaatt accaatcccg cggcttactc cttgatttgg gtgaaatggg
     7801 ccagtactgg tacccactac ttccacccgt tccgtttaca gccccggtct gctttccagc
     7861 tgaaattctc cttgagtgta agctgaccaa ctcgattcgt acgctgtctt tgaaagaagt
     7921 gatgcgcggt acccgcctca accagatttt ccagtcagcc ggattcgcac aggttgacgc
     7981 cgcccttcct gacggttttg aggtgatgca ggaacccggt tttctggcct tgttggatac
     8041 acatgggaac gtcattgatg aatctctggt tgccctgaga gacaacctgc tggcaaaaac
     8101 gccggatgaa gaagccgtgg tactggcgac cctctgccag caacacccct ttggtaggga
     8161 cagcctcttg gcggcacggg ttaaacagct tgcagcccac ttggcaacga cacccgaaaa
     8221 tgcggctatc aagtggtttg acaactattg tcatcaggta gtgggctcgc ttttctcttt
     8281 acagggaaac ggcggcattg tctgtctggc ccaccagcaa aacattgtca tgcgcctgca
     8341 agatggcatg ccggtgggga tgtattaccg ggattgtcag ggcaccggtt ataccgacct
     8401 tgcctacacc cttttcccgg acatattgat tgacgacacc caagatttgg aaaaccactg
     8461 ggagcaggaa aaggtactgc gctatttccc ttattacttg attatcaact ccacatttag
     8521 cgtcattgca tcactgtccc ttcattgcgg tgtgtctgaa ggcgcgttac tggaaaggct
     8581 gcgtgcctat ctgaaatcct taaaaggaaa gctggtagat acccattgtc ttaactatgt
     8641 gctggagagc ccagccctat gctgcaaagg taatttctac tgttatctgc aagatctgaa
     8701 tgaaaacgcc attcccgatc cgaaagtgat ctatttcgac ctgccgaatc cactggtatg
     8761 ccatgcaacc gacaaccgtc catcaagtga aaaggaagcc cactatgtct gattgccagc
     8821 tgtccctctc cccgactacc gacaagcatc acttagacga tatttttcct ttgctggagc
     8881 cagaaatgct gattgcagcc ggagaaaaaa acagtggaga tagccttgcc agcgccttag
     8941 atcactactt ttgcgtgaac cctaaatcac cggcagtgca attaccgcgt gagcgctgga
     9001 attctcacat tgccccttca cactggcttt acatgtttct tgatgatgtc ctgacccgct
     9061 ctcagtttaa tcaattaccc gcgacaggtc tttgtcatat gccgacggat cgctaccccg
     9121 cgttgccggt tcaaagcacg aagcaatcgg gttttcatcc caaacgtccg gcttctccaa
     9181 aaggttacgt gtaccagcgg actgaccctc tgaacggcat aacagtcagc tatcgtcttt
     9241 ttgaacctga aaaggatatg ccccgtttca cccgctggat gaactgccca cgggtggccg
     9301 atttctggga gcaggcatgg tcagaagaag cacttctcga ctatatcaat gggcggttgt
     9361 cagacccgca cactttgccg ctaatcggtg agtttgacgg ccaacccttt gggtacatcg
     9421 aagcgtattg ggtcagcgaa gacaggttgg ccccttacta tgacagccag ccttttgatc
     9481 gtggcatcca cgtgctggtc ggtgaagagg cgttccgtgg cgaacggtat ttcaatatgt
     9541 ggatgcgcgc catcacccat tacctgttcc ttgacgactg cagaacaatg cgtgtcgtgc
     9601 ttgagccgcg ttatgacaac acaaggctgt tcaaccgcat taaaagcgtc ggctacaaac
     9661 agaagttcct gttcgatttc ccccacaaac gcgcggcatt aatgatgact tcccgttatg
     9721 cttttttccg ggagcaatgg taatggaaca gaatgccctt caccgtttct ggcccgcagc
     9781 aaaccgggcg ttggttgcca agctcatcag cgagctggaa tacgaacagg cgttcaaact
     9841 cgaacctgtc ggtcaagaac actgccttac tctgcccgct ggcgtgcgtt accgggtgaa
     9901 aggcaaacgc aacatctggg gacagctcaa tatcctgccc gggagtattc gccgggagga
     9961 taacggggaa cataacctgc cagttgaagc aagccgcttt atgctggatt gcaaaaccgt
    10021 actgggattg gatgacgata cgctggcaga gcacctggaa gatctttacg ccaccctgct
    10081 gggcgattgc aagttaatgc agctcaggga gcatctcgac gctgatgcct ttgcccggtt
    10141 atcactcgaa aagcaacaat gcctgtttga cggccacccc aagtttgtct ttaacaaagg
    10201 gcggcgtgcc tggggaagtg aggatttacg ccattttgcg ccagaaagcg aagagccgtt
    10261 tcagctgtgc tggatagcgg taaaccacac cttagtcact ggcgctatct cagaatacct
    10321 taactggaac catctctatc aaaacgcgct ctctgacgac gatttggcct ctgtccgttg
    10381 tgatctggag atgcttggtc ttaacccggc aaacttcctg ttgcttccgg tgcatccatg
    10441 gcagtgggac aacaagctgt ctttgttgtt tgtggctgaa cttgccagaa aagaaatggt
    10501 ttaccttggc acgttcgggg atgcatttct gccacagctg agtctgcgca cactgaccaa
    10561 tgtgtcacgc ccagcgcgct acgacatcaa gttgccgctc accatcatga atacttcctg
    10621 ctaccgggga atgccatcac gctacattca agccggaccg caggcgtctg catggctgga
    10681 gaacaccgtg aaaagcgatc ccctttttat ctcgctgggc acagacgtat tgcaagaacc
    10741 tgcgggtttg accgtttcac acacagtgta tgactcgctc gaaaaggcac cttaccgata
    10801 ccacgaactg tgcggtgcca tctggcggga atctgccagc acaaaaaccc ggcccggcga
    10861 gcaggctatc ctgatggcag cgctgatgga gtctgacagt gctggcaacc ctctgattgg
    10921 cgcttacatc cgcgcatcgg gcttatctgc caaagactgg ctttcacagc tgttccgggc
    10981 cgtggtgatc ccttattacc atctgttggc gaaatacggt gtatcactca tcgcccatgg
    11041 gcagaacgtg acgctggtac tggaaaacag caccccgaaa cggattctgt taaaagattt
    11101 ccaaggtgac atgcgcctga tgcagggtga tattcccgag caagacagcc ttccacaggc
    11161 ggttaaagat gtcaccgtca ccttgcctcc agatctgatc attcacgatt tgcaaaccgg
    11221 tcatttcgtt actgtgctgc gttttatctc gccccttgca gaaaaaaccg gcgtcagcga
    11281 acaccgcttt tacaaactgc ttgcccagga attgcaagct tacatgcaat cacaccccga
    11341 gttggaagcg cgtatccagt tgctcgattt gttccgccct aaaatccgtc gattggggct
    11401 gaacctcgcc aagttccgtc atgcgacaga aaacagtgca gatcgcatgc tgccgcagat
    11461 ggagcatttc atcgacaatc cgttgtatct ggtcacccat tgaaaaggac agaaaaatga
    11521 caacgacgat atcttctcag gttttagatt tagcaggcat tggagccggg ccctttaacc
    11581 tcagtgttgc ggcgctttta caacaagtac cggaaacgaa gtactgcttt tttgaaagtc
    11641 gggatagcgt gagttggcac ccgggaatgc tgcttgatga tacccacatg caaaccactt
    11701 tcctgaaaga tctggtgacg ccggttttcc cccaaagccc gtattcattc ctcgcctatc
    11761 tggtggaaaa gaaacgcatc tatcgcttcc tgacggctga gttgggttgt atttcacgaa
    11821 cagagttttc cgattatctc tactgggcct cagaaaaatt acccaatatt gcattctcaa
    11881 cctgcgttga aaaaatcgag tttgccgacg gggtgttcca catccacacc gacaaaggca
    11941 caacgcttgc ccgcaacctg tgccttggca ccggaaaatc cccgcatgtg ccagagtgca
    12001 tgaagcccta cattggcgaa cacattttcc atgccgcgga aatcgccctc agcccacggg
    12061 atttcaccgg aaaacgggtc gctatcattg gtggcggcca aagtggtgcg gatgttttca
    12121 ttaatgcatt gcgtggcacc tggggcaagt tcgcaaagct cgattgggta tcccgcaggc
    12181 cgaattatca gcctctggat gaagccgctt ttaccaacga gtatttcaca ccggactatg
    12241 tagaagcgtt tcttaccctt tcgccagacg taaaagcccg cgaagtcagc atgcaaaagc
    12301 tgacctcaga tggcgttacc cagaaagcgt tattggaaat ctatcgcgag ctttaccagc
    12361 ggtttgatgt caacaacgaa gagaagtggg ttcgcctcct tccccaccgc acggtgacac
    12421 agcttctctc tcacaaagga gggtatgaac tgtttcttga gaatgggctg gctaaccaac
    12481 tagaacggct tgatgccgac atcatcatac tcgccacagg gtatgaaagc cgcacgccac
    12541 gttgccttga tggactgagg ccgcttatca atgccgacag tgaaggcagg ttccagctaa
    12601 accaatattt cgaggtggag tgggcacaca gcgacacgaa caggatattt gccgtgaatg
    12661 tcggtatgca cagccacggc attgccgagc ctcagctcag cctgatggca tggcgatcag
    12721 cacaaatcat taaccggttg tgccaaaaac ctgtattcaa cacagaagca ggacccgcgc
    12781 ttatcgagtg gataagccca acatcccttg ttgaggcttt cgcatgaacc acgctttttg
    12841 cgccctgctg cccgaactgc aagaaggcac gctgaatacg cggttggcgc tgcttaaccc
    12901 agcgtggcgt tggcaagtcg ccccggagaa ggccgtgcct ttggggagtt tgttgaaaga
    12961 cgacctcgtt gccagacgca ccgttgttgc ttttcaggat acgcatcagg cccccactac
    13021 caaagtggcc gcctcattgg tccataagca atggatagct aacctgctct ctccttagtg
    13081 gccgtgtacc tgctgtcagg aaggcagcct gaacagtggc aaaagctggg atatgacgta
    13141 gaaaaaggtt gtctgggatg gacaacacaa ccttttgggg aacacaccaa tccggcgttg
    13201 tttattgaaa ccacgacggc tgtcgccaat gcctgctaca cactgtttcg acggcacttt
    13261 tctgtccctc cccgtgttct ttggagtaac accgcattgg cgctggcagc ccctggcatc
    13321 gcttacagaa tctcggcgcg ggtggagaag ccatcaataa tcaattgacc gcattctttg
    13381 cccactttcc ctcgccactg tcgcaaagtg tcaagtggct ggttatcaga gagaacggga
    13441 aaagcctctg tgtaccacgc aggctgggtt gctgcctcaa atatgccctg cccggcaaca
    13501 ggaacacact ttgtggcacc tgccaccgac gcagtgaaca agaacaaata gcgcttgttc
    13561 accaacgttt ttttacagaa ataaagtaat acgaatcact attaaatgca ttcatttatg
    13621 catctagtgt ctgcgcgata cgtcttttaa acaagggcac aggtatcgca atgattgaaa
    13681 cgataaatat aaggtaatta gaagtgaaat tatcaaggac gtttataacc aaccccttca
    13741 ccctggccat ttgtgctgct atcactaccc agtcaccagt ggtatcagca tcaacagata
    13801 ctgaaggacg cgccccactg gatacagtag ttattaccgg tcgaagcgaa aaagtgattt
    13861 cggatatcgc cggaacagta tgggtcgttg acagcgaaca aatcgaacag caataccggg
    13921 gcggtaaaaa cctcagtgaa atactggcga gcgccgtgcc tgcactggat gtaagcagtc
    13981 agggacggac aaactttggc cagaatatgc gtggccgccc gatgttggtc atgattgatg
    14041 gtgtttccct caactcctcc cgctctgtca gtcgacagtt ggatgcgatt gatcctttca
    14101 atatcgcgtc cattgaagtg ttgtcggggg catcatctat ctacggcgca ggggcaacgg
    14161 gcgggatcat taacattgtc acctttcgtg cagacgccag cgaactggcc tttgaaagct
    14221 atgctggcgc caccagcggc ttcaacggcg gagaggattt tgactacaaa atcgcacagt
    14281 cagtcagcgg cggaaacgac aaggtaaaag gccgtgtgtc tgtggtctat ggtgaaaaca
    14341 aaggtgcctt tgatgccgac ggaaacatca atgtgccaga catcacccag gggtccctgc
    14401 agtttaatga ggttgtagac gtgctcggca cactcaacat cacaccagac agtgcccaga
    14461 gcatccaact gctggcccag tattactcca gcaagcagga tagcccttat ggcatttact
    14521 ttggtgaaaa ccttgccggt gcgccgaaca acattaccgg taatcctgcc gataccagcc
    14581 tgatagaaac ccgtaaaggc ttcagctcag acaggcaagg tggcacagag cgcttgatgt
    14641 tgaatgccaa ttaccatcac aacaatgtac tggggcagga tctgtttctc caggcttctt
    14701 tccgccgcga agagttttca tttattccgt ttatttatgg ctcttacctt gcggcatccg
    14761 aacaaaacac ggatgtgctc actcttcgtg ccgccatggt caaatcaatg gataacctca
    14821 cgctcacgta cggtattgac agctatcttg acaaactcac gtccaatcag gcgttgttcg
    14881 accgcaacct gagctatcag agcggcgggt tgattaaccg gactgaggcc aagatcgggc
    14941 gttatcccgg tacagaagtc gcatcagtcg caggcttcgt acaagctgac tatcaattga
    15001 cggacgactg gtcgctgtct gggggatatc gttaccagtg gatgcaaaat accatcgatg
    15061 acttcgttgc cgcatccgtc caacagcaaa ttgcgcaggg taatggcacc tcagcagacg
    15121 ccgttccggg aggatcgacc gactatacta ttggcctgtt caaccttgga accgtatata
    15181 aactctcgaa aaacgcccag atctgggcca acttctcaca gggttttgat ctcgcagacc
    15241 ctgcaaaata ctatggccag ggcaattaca gcgccccgga tgccaatggt caccacacac
    15301 tgaccgacag catcaatgtc tccagttcta agatgcaggg cattaaaacc aacagcgtcg
    15361 agatcggcgc acgacaatac ttggatgcac tgagctggca agcggcagct tatatctctg
    15421 aatcagacaa aacactgaaa tataacagac aaaccctgaa tatcgatgta aacgacgcca
    15481 aaaaacgcat ctacggaatt gaagctgaag ttgcatactg gctcacggac aacctgcaaa
    15541 ccggcttaac cggacactgg gttgattcag aagagcagga cagtgaagga aaatggtcga
    15601 agatgtcggt caactacgcc agcgcctcaa aggccggagc atggttaggc tggtacgaag
    15661 acaattattc agtccggctc cagaatcaaa ccctgtttga tctgagcgat gagaataacg
    15721 gtaaaattga cggttacagc ctgtttgatc ttatcggtac ggttgagctg ccaaaaggac
    15781 gcctcggctt tggcatccaa aacctgctga acgaagacta caccacggta tggggacaac
    15841 gtgcaaaagg ctggtacagt tattatggcc ctgaagagat gtttgattac agaggtcgtg
    15901 ggcgtactta tacgctgaac tatagccttt cttattaacc atcgatcaaa tctgttgaat
    15961 atccatcaag gggacagcgt cgctgtcccc ttttttatgg tcctctaaga gtattcaagt
    16021 atcgcagaaa gacgctgaca accatcggga taaatatctt tatcatcttc cctgatcaat
    16081 agtaatgaat gtagtcgcgt atcagtctca ataaagggga agtgaacaac actgctttac
    16141 tgatattcgc tatcgctttt gcgccatttg cagtgagcaa taccgggaaa agggacaaaa
    16201 atcgtttagt gatataattc aaaacgacta ctgaagtgaa agcgaaaagc gttgtgaatc
    16261 actcttaaat ttcttgatgt aattattctc taggcatttt tctaagctga attgcaatat
    16321 cagctgctgt cggggcagtt atagcgtaat acaagctgac ggtacc
//
