Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000940.1:
Cluster 1Other17328

BGC0000940, desferrioxamine B biosynthetic gene cluster from Streptomyces coelicolor. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Desferrioxamine B
PubChem ID: 2973
SMILES string: Copy to clipboard
Molecular formula: C25H48N6O8
Average molecular mass: 560.693 Da
Molecular activity: Siderophore

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
None

Gene cluster description

desferrioxamine B (BGC0000940). Gene Cluster 1. Biosynthetic class = Other. GenBank AL645882, positions 3033355-3040682. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Francisco Barona-Gomez (National Laboratory of genomics for biodiversity-CINVESTAV)

Literature references

1. Barona-Gomez F et al. (2004) Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145. J Am Chem Soc 126(50):16282-3. doi: 10.1021/ja045774k.
2. Barona-Gomez F et al. (2006) Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877. Microbiology 152(Pt 11):3355-66. doi: 10.1099/mic.0.29161-0.
3. Kadi N et al. (2007) A new family of ATP-dependent oligomerization-macrocyclization biocatalysts. Nat Chem Biol 3(10):652-6. doi: 10.1038/nchembio.2007.23. Epub 2007 Aug
4. Tierrafria VH et al. (2011) Disruption of the siderophore-binding desE receptor gene in Streptomyces coelicolor A3(2) results in impaired growth in spite of multiple iron-siderophore transport systems. Microb Biotechnol 4(2):275-85. doi: 10.1111/j.1751-7915.2010.00240.x.