LOCUS       BGC0000945             10811 bp    DNA     linear   BCT 31-JAN-2014
DEFINITION  Vibrio cholerae O1 biovar eltor str. N16961 chromosome I, complete
            sequence.
ACCESSION   BGC0000945
VERSION     BGC0000945
KEYWORDS    .
SOURCE      Vibrio cholerae O1 biovar El Tor str. N16961
  ORGANISM  Vibrio cholerae O1 biovar El Tor str. N16961
            Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales;
            Vibrionaceae; Vibrio.
COMMENT     On or before Mar 7, 2007 this sequence version replaced AE004093.1,
            AE004094.1, AE004095.1, AE004096.1, AE004097.1, AE004098.1,
            AE004099.1, AE004100.1, AE004101.1, AE004102.1, AE004103.1,
            AE004104.1, AE004105.1, AE004106.1, AE004107.1, AE004108.1,
            AE004109.1, AE004110.1, AE004111.1, AE004112.1, AE004113.1,
            AE004114.1, AE004115.1, AE004116.1, AE004117.1, AE004118.1,
            AE004119.1, AE004120.1, AE004121.1, AE004122.1, AE004123.1,
            AE004124.1, AE004125.1, AE004126.1, AE004127.1, AE004128.1,
            AE004129.1, AE004130.1, AE004131.1, AE004132.1, AE004133.1,
            AE004134.1, AE004135.1, AE004136.1, AE004137.1, AE004138.1,
            AE004139.1, AE004140.1, AE004141.1, AE004142.1, AE004143.1,
            AE004144.1, AE004145.1, AE004146.1, AE004147.1, AE004148.1,
            AE004149.1, AE004150.1, AE004151.1, AE004152.1, AE004153.1,
            AE004154.1, AE004155.1, AE004156.1, AE004157.1, AE004158.1,
            AE004159.1, AE004160.1, AE004161.1, AE004162.1, AE004163.1,
            AE004164.1, AE004165.1, AE004166.1, AE004167.1, AE004168.1,
            AE004169.1, AE004170.1, AE004171.1, AE004172.1, AE004173.1,
            AE004174.1, AE004175.1, AE004176.1, AE004177.1, AE004178.1,
            AE004179.1, AE004180.1, AE004181.1, AE004182.1, AE004183.1,
            AE004184.1, AE004185.1, AE004186.1, AE004187.1, AE004188.1,
            AE004189.1, AE004190.1, AE004191.1, AE004192.1, AE004193.1,
            AE004194.1, AE004195.1, AE004196.1, AE004197.1, AE004198.1,
            AE004199.1, AE004200.1, AE004201.1, AE004202.1, AE004203.1,
            AE004204.1, AE004205.1, AE004206.1, AE004207.1, AE004208.1,
            AE004209.1, AE004210.1, AE004211.1, AE004212.1, AE004213.1,
            AE004214.1, AE004215.1, AE004216.1, AE004217.1, AE004218.1,
            AE004219.1, AE004220.1, AE004221.1, AE004222.1, AE004223.1,
            AE004224.1, AE004225.1, AE004226.1, AE004227.1, AE004228.1,
            AE004229.1, AE004230.1, AE004231.1, AE004232.1, AE004233.1,
            AE004234.1, AE004235.1, AE004236.1, AE004237.1, AE004238.1,
            AE004239.1, AE004240.1, AE004241.1, AE004242.1, AE004243.1,
            AE004244.1, AE004245.1, AE004246.1, AE004247.1, AE004248.1,
            AE004249.1, AE004250.1, AE004251.1, AE004252.1, AE004253.1,
            AE004254.1, AE004255.1, AE004256.1, AE004257.1, AE004258.1,
            AE004259.1, AE004260.1, AE004261.1, AE004262.1, AE004263.1,
            AE004264.1, AE004265.1, AE004266.1, AE004267.1, AE004268.1,
            AE004269.1, AE004270.1, AE004271.1, AE004272.1, AE004273.1,
            AE004274.1, AE004275.1, AE004276.1, AE004277.1, AE004278.1,
            AE004279.1, AE004280.1, AE004281.1, AE004282.1, AE004283.1,
            AE004284.1, AE004285.1, AE004286.1, AE004287.1, AE004288.1,
            AE004289.1, AE004290.1, AE004291.1, AE004292.1, AE004293.1,
            AE004294.1, AE004295.1, AE004296.1, AE004297.1, AE004298.1,
            AE004299.1, AE004300.1, AE004301.1, AE004302.1, AE004303.1,
            AE004304.1, AE004305.1, AE004306.1, AE004307.1, AE004308.1,
            AE004309.1, AE004310.1, AE004311.1, AE004312.1, AE004313.1,
            AE004314.1, AE004315.1, AE004316.1, AE004317.1, AE004318.1,
            AE004319.1, AE004320.1, AE004321.1, AE004322.1, AE004323.1,
            AE004324.1, AE004325.1, AE004326.1, AE004327.1, AE004328.1,
            AE004329.1, AE004330.1, AE004331.1, AE004332.1, AE004333.1,
            AE004334.1, AE004335.1, AE004336.1, AE004337.1, AE004338.1,
            AE004339.1, AE004340.1, AE004341.1, AE004342.1, AE004343.1.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:28:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10811
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10811
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[129:7383]"
                     /cutoff="30000"
                     /detection_rule="(VibH_like or Cy_tandem or
                     (cds(Condensation and AMP-binding) and ((IBH_Asp and not
                     SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or
                     CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD
                     and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox
                     and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))"
                     /neighbourhood="20000"
                     /product="NRP-metallophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      130..7383
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="30000"
                     /detection_rule="(VibH_like or Cy_tandem or
                     (cds(Condensation and AMP-binding) and ((IBH_Asp and not
                     SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or
                     CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD
                     and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox
                     and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))"
                     /neighbourhood="20000"
                     /product="NRP-metallophore"
                     /protocluster_number="1"
     cand_cluster    1..10811
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(VibH_like or Cy_tandem or
                     (cds(Condensation and AMP-binding) and ((IBH_Asp and not
                     SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or
                     CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD
                     and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox
                     and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))"
                     /kind="single"
                     /product="NRP-metallophore"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10811
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000945"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10811
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRP-metallophore"
                     /region_number="1"
                     /rules="(VibH_like or Cy_tandem or (cds(Condensation and
                     AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or
                     TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or
                     (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or
                     PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like))
                     or Lys_monoox or VbsL)))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(130..7383)
                     /NRPS_PKS="Domain: Heterocyclization (6-306). E-value:
                     9.5e-111. Score: 361.8. Matches aSDomain:
                     nrpspksdomains_VC_2209_Heterocyclization.1"
                     /NRPS_PKS="Domain: Heterocyclization (458-725). E-value:
                     8.5e-33. Score: 105.8. Matches aSDomain:
                     nrpspksdomains_VC_2209_Heterocyclization.2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: Cy_tandem"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     60; E-value: 3.9e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="VC_2209"
                     /sec_met_domain="Condensation (E-value: 2.3e-37, bitscore:
                     116.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="Cy_tandem (E-value: 2e-168, bitscore:
                     547.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MGLKMKEMTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQA
                     LTEAVRALYAKHPMLRLAITKDGQQKILPLSTFHQLKVDDLSQWKPDEVESFVHTKRQR
                     MTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAIEH
                     RLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAV
                     SANSQRFAHWFTPVERKGLAEVARQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFH
                     RGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLHQLLRHESYSGVSVMRD
                     LSRKQGGVQRSPIVFTSGMEMRDEEIFSDHVTQHLGRMNWVISQGAQVTLDAQIAPAYE
                     GILLNWDVRMENFADKDITALFAHYVDLIRCVALHPEMMQQSVQQIDAQLGYARRESIQ
                     EMPLTPLQQAYLLGRSTQIALGGVAMHEFREYRGHIDTQSLHSRLLYLVEHIPALRTRI
                     DQEKWIQWVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPWQICVVQ
                     LPIEEQEEFSSIVLTSFDALIVDGRTHALILAALLGSEEPDITQVVQNARDTQSISPQF
                     ASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVGKLNRCGIE
                     NGLFLNSLLTATILDVLSYWTTEIGMRVGFPVLIPSSNAIDGNESSFVILEHEKSTLSL
                     LSQASKLQREMLEALEHLAFSGVDLNRLLMNQAPQALVLPVVLTNGLSWKTLNPEDAVT
                     LFDGVTQTPQWL"
     gene            complement(131..7383)
                     /locus_tag="VC_2209"
                     /note="VC2209; This region contains an authentic frame
                     shift and is not the result of a sequencing artifact;
                     similar to GP:6031222; identified by sequence similarity;
                     putative;nonribosomal peptide synthetase VibF, authentic
                     frameshift"
     CDS_motif       complement(4981..5010)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0015"
                     /evalue="7.30E-01"
                     /label="Cy6"
                     /locus_tag="VC_2209"
                     /protein_end="801"
                     /protein_start="791"
                     /score="3.5"
                     /tool="antismash"
                     /translation="LPVVLTNGLS"
     CDS_motif       complement(5041..5085)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0014"
                     /evalue="8.10E-03"
                     /label="afterCy5"
                     /locus_tag="VC_2209"
                     /protein_end="781"
                     /protein_start="766"
                     /score="9.3"
                     /tool="antismash"
                     /translation="ALEHLAFSGVDLNRL"
     aSDomain        complement(5209..6009)
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_VC_2209_Heterocyclization.2"
                     /evalue="8.50E-33"
                     /label="VC_2209_Heterocyclization.2"
                     /locus_tag="VC_2209"
                     /protein_end="725"
                     /protein_start="458"
                     /score="105.8"
                     /tool="antismash"
                     /translation="EMPLTPLQQAYLLGRSTQIALGGVAMHEFREYRGHIDTQSLHSRL
                     LYLVEHIPALRTRIDQEKWIQWVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQRM
                     HDLTRSPWQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALILAALLGSEEPDITQV
                     VQNARDTQSISPQFASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQI
                     PKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFP"
     CDS_motif       complement(5239..5298)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0013"
                     /evalue="6.70E-02"
                     /label="Cy4"
                     /locus_tag="VC_2209"
                     /protein_end="715"
                     /protein_start="695"
                     /score="6.5"
                     /tool="antismash"
                     /translation="GLFLNSLLTATILDVLSYWT"
     CDS_motif       complement(5581..5613)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0012"
                     /evalue="2.20E-01"
                     /label="Cy3"
                     /locus_tag="VC_2209"
                     /protein_end="601"
                     /protein_start="590"
                     /score="5.3"
                     /tool="antismash"
                     /translation="TSFDALIVDGR"
     CDS_motif       complement(5824..5868)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0011"
                     /evalue="9.20E-02"
                     /label="Cy2"
                     /locus_tag="VC_2209"
                     /protein_end="520"
                     /protein_start="505"
                     /score="5.7"
                     /tool="antismash"
                     /translation="LVEHIPALRTRIDQE"
     CDS_motif       complement(5965..5994)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0010"
                     /evalue="4.80E-02"
                     /label="Cy1"
                     /locus_tag="VC_2209"
                     /protein_end="473"
                     /protein_start="463"
                     /score="6.9"
                     /tool="antismash"
                     /translation="PLQQAYLLGR"
     CDS_motif       complement(6052..6120)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0009"
                     /evalue="2.30E+00"
                     /label="C2_starter_024-063"
                     /locus_tag="VC_2209"
                     /protein_end="444"
                     /protein_start="421"
                     /score="1.1"
                     /tool="antismash"
                     /translation="AHYVDLIRCVALHPEMMQQSVQQ"
     CDS_motif       complement(6166..6240)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0008"
                     /evalue="9.80E-05"
                     /label="Cy7"
                     /locus_tag="VC_2209"
                     /protein_end="406"
                     /protein_start="381"
                     /score="15.4"
                     /tool="antismash"
                     /translation="ISQGAQVTLDAQIAPAYEGILLNWD"
     CDS_motif       complement(6307..6330)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0007"
                     /evalue="4.00E-02"
                     /label="Cy6"
                     /locus_tag="VC_2209"
                     /protein_end="359"
                     /protein_start="351"
                     /score="7.1"
                     /tool="antismash"
                     /translation="PIVFTSGM"
     CDS_motif       complement(6361..6405)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0006"
                     /evalue="1.20E-04"
                     /label="afterCy5"
                     /locus_tag="VC_2209"
                     /protein_end="341"
                     /protein_start="326"
                     /score="14.8"
                     /tool="antismash"
                     /translation="LRHESYSGVSVMRDL"
     aSDomain        complement(6466..7365)
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_VC_2209_Heterocyclization.1"
                     /evalue="9.50E-111"
                     /label="VC_2209_Heterocyclization.1"
                     /locus_tag="VC_2209"
                     /protein_end="306"
                     /protein_start="6"
                     /score="361.8"
                     /tool="antismash"
                     /translation="EMTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVR
                     ALYAKHPMLRLAITKDGQQKILPLSTFHQLKVDDLSQWKPDEVESFVHTKRQRMTHQML
                     DLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAIEHRLEIIE
                     SDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQR
                     FAHWFTPVERKGLAEVARQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSL
                     DIEHTIGDFSNLLIFSADV"
     CDS_motif       complement(6469..6522)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0005"
                     /evalue="1.60E-04"
                     /label="Cy5"
                     /locus_tag="VC_2209"
                     /protein_end="305"
                     /protein_start="287"
                     /score="14.2"
                     /tool="antismash"
                     /translation="DIEHTIGDFSNLLIFSAD"
     CDS_motif       complement(6586..6639)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0004"
                     /evalue="3.20E-03"
                     /label="Cy4"
                     /locus_tag="VC_2209"
                     /protein_end="266"
                     /protein_start="248"
                     /score="10.6"
                     /tool="antismash"
                     /translation="HLTLTQLTLALFSQVIAN"
     CDS_motif       complement(6949..6993)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0003"
                     /evalue="6.70E-05"
                     /label="Cy3"
                     /locus_tag="VC_2209"
                     /protein_end="145"
                     /protein_start="130"
                     /score="16.1"
                     /tool="antismash"
                     /translation="RLHIDADMIACDAQS"
     CDS_motif       complement(7174..7227)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0002"
                     /evalue="5.20E-07"
                     /label="Cy2"
                     /locus_tag="VC_2209"
                     /protein_end="70"
                     /protein_start="52"
                     /score="22.0"
                     /tool="antismash"
                     /translation="LYAKHPMLRLAITKDGQQ"
     CDS_motif       complement(7327..7353)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VC_2209_0001"
                     /evalue="1.30E-02"
                     /label="Cy1"
                     /locus_tag="VC_2209"
                     /protein_end="19"
                     /protein_start="10"
                     /score="8.5"
                     /tool="antismash"
                     /translation="MQAAYWLGR"
     gene            complement(7629..8444)
                     /locus_tag="VC_2210"
                     /note="VC2210"
     CDS             complement(7629..8444)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200:vibriobactin
                     utilization protein ViuB (Score: 278.6; E-value: 7.4e-85)"
                     /gene_kind="other"
                     /locus_tag="VC_2210"
                     /note="similar to GB:U11759 PID:531823 SP:Q56646;
                     identified by sequence similarity; putative"
                     /product="vibriobactin utilization protein ViuB"
                     /protein_id="AAF95354.1"
                     /transl_table=11
                     /translation="MSNEVERVYPRLLDFVRKKYVSKNLLRVTLTGEDLIGFPEDQNGS
                     HIKVFFPNQASGILQLPIREGDKVIWPEHKPVPRAYTVRQYRAQSNELDIDFVVHGEGT
                     PGGGWALKAQTGSQLGLIGPGGPDPLIEPADWHIMAGDLSAVPAISAILEKMPSQAKGY
                     VFLEVDDIEDKHDISHPEQMVIKWLVRDPNQAQPVLAMAIEQLPVPQGAESLSAFVAGE
                     NESVIACRKILRNEYRIARDKIYAIPYWKRGKNEEAYHEERHVVMDEEF"
     gene            complement(8748..10811)
                     /locus_tag="VC_2211"
                     /note="VC2211"
     CDS             complement(8748..10811)
                     /codon_start=1
                     /gene_functions="transport (smcogs)
                     SMCOG1107:TonB-dependent receptor (Score: 672.4; E-value:
                     1.1e-203)"
                     /gene_kind="transport"
                     /locus_tag="VC_2211"
                     /note="similar to SP:Q00964 PID:531822; identified by
                     sequence similarity; putative"
                     /product="ferric vibriobactin receptor"
                     /protein_id="AAF95355.1"
                     /transl_table=11
                     /translation="MAVLCPARVSVAENKKFKLHTLSAMMMGLFTGSFAYAETQNTSNQ
                     EQEMPVLVVIGEKTQRSIYETSASVEVFDQDTIERTPGATEIDDLLQLIPNLVDSGQSN
                     NMPTIRGIDGSGPSVGGLASFAGTSPRLNMSIDGRSLTYSEIAFGPRSLWDMQQVEIYL
                     GPQSYIQGRNTSAGAIVMKSNDPTHHFESAVKAGIGESDYSQTAGMISAPIIQDELAFR
                     LSFDQQKRDSFVDLAAFEPAGDPKKIEMNSVRGKLLYEPSALDGFKTTLTLSHMDSRGP
                     QTENINVAGNEAFRPVYETASFTTAWDIIWHLNDLFTFENNLVYADFSYDRYTNPNSRG
                     DFNTDGKEFHIEPLLRYIALDGSVNTLIGARYYQSSQDDMYIDAASAYPMDGRTKAKSV
                     FAEVTYALTPSINVNLAGRFEREQVKRNVSHPRYKLDYDETSSVFLPKLDVAYTPVQGQ
                     TYGIKAAKGYNASGAGLAFNSMQFTGFRPYEFEQESIWNYEFYTRHRFSHSVEVLTNLF
                     YNDFDSMQMTQTTSSGDVFIANLDEASTYGAEIGSRWYATSSLELFANLGLLKTEFKET
                     TGNTKELPRAPKMSANVGLLYDFGQGFEFSSNAAYTGSYFSESGNSEKFAIDSYWVANA
                     QLAYVFEHGRATLYATNLLDSDKTTLYLSTNNTLDQLKQQPRMIGASVQLNF"
ORIGIN
        1 gctcaatcat caagttcaag ccctgaactg ccacgactgg cacttcaggg cttgtcataa
       61 agggggagcc aatatcgccc ttcgccccct attccctacc actacgatat cgagtcacga
      121 cacaaaaaca ctaccccatg gacggagagc gacaagcttc atcttcaagc tgcctcacct
      181 gctttttcag cgtcggcagt gcaatatctt gtgcaataca atcggaaaac cgctcaaaca
      241 tgccactggt taccttggtc aacagagcga cttgagctgg gctatagtgt ttcgacatat
      301 aactcatcat gactctcaac gtctgctttt gctcgatcct ctcttctaaa atttcaaact
      361 gtaaacctaa gccggattca cttttatcgg gatcgacttg ttggaagcgg atcgcatgcc
      421 cttctgtcaa cagtagctct ccatgcagct tattttttgc atgcagttgt ataaagacct
      481 caaacatgtg accttccgtc tcatgctcaa cacctttgag cccttcttca atcaggtcaa
      541 tcggaatatc tgtgtatggc atcgactggt taatgctgtt tttcacttgc tcgatgagtt
      601 gccacaccgt ttgtactttc gtgaaatcca ccaactgaac gcccatggta gtgaaataac
      661 cgactgtgtc gaaaaactcg gcatccagcc gaccggaagc aggtgtgcca accagcagct
      721 tttctggtgc gccgagacaa tgtaccgacg cagaaatcgc cgcatacatc acgttaaaca
      781 acgaagcatg gcgtgcttta gccaattgat acagcgatac catggttgat ttcggcaatt
      841 ttatttcgac ccagccgcct tctccaagat cgacgccagt gctgttactt aaaggatgat
      901 ccgcagcaaa cagaggctgt gcccaaggca caccggcaaa cttggttaac caatagttaa
      961 gatgcgtttg attgaatgcc gaagaacgct gcttgcgagc aaactcatgg aaaggtaagg
     1021 gttccgtttg ccactgtgga cgagtacctt gcacactgtg ttgatacacc tgtgctaatt
     1081 catccatcaa aatattgatc gaccactcat ccaacacaat atggtggaac agaagtgaaa
     1141 gatattgcgt ccccgtctgt tcatcacgta cgaaattgag tcgaagtggc aattcttggc
     1201 tcaggtcaaa ggtgtgctcg gcctcttgcg ccagtagtct ggccacggat tgggcggcgt
     1261 tatctttaga cgtccagaac cactggtaat gttctatgtt gctggctgcg atcacgtgct
     1321 ggtaaggctg cccatcttct aggccaaagt gggttcgtaa cccagcatga cgcagtaaaa
     1381 gccagtgaaa agcctcacca aatgcttgct cattgacctc atctaaaaat ttaagcgcaa
     1441 acggaagatt gaagatgtgg gtcaaaccaa acttggcgta tttgctcatc gccttccata
     1501 aagaggcttg tgctaacgac aaaggcgctt tggacgactc gaccacctca ctcactgcga
     1561 atgatgtgct ggtgggttta cggtgaagta cggcttgctg cgccagttgc ttggcattag
     1621 ggaaactaaa catatcattg atgtgcagtt caataccttg ctcgctcaac aagcgaccaa
     1681 tgactcgcgt tgcgatcagg gaatgtccgc caaaatcaaa gaaatcatcc tctgccgtca
     1741 tctcggcaac accaagtgct gagcgaaact cagccaaaat gcactcttca accgcagagg
     1801 aatttacagc gctcaattca agctcagact ctgccaacgc cgcatgcgca ttgtttgagg
     1861 tcggcggatt gtttgacgtc aactcaatgg ctgagacatg agaggatgag gttgtcgaag
     1921 aaggcattgt tcgcccacct atcgcagcga caaattgctc aagcaagtag gctccgacat
     1981 ggggggaaac cgtggcatct aacgccagct caagtactag ggcaccttgg caattaagcc
     2041 caacccccaa ggcgacttca aatttggggt gcatggctgc aaaaagtaat ttttcgcagc
     2101 gcaagccctc caattgtaga tgcactgaag gatccactaa ccaagtcacc aaggctgcgg
     2161 cagaggcgtg agtttcgcta gcgactcccc ccgttaacgg ctggcgcata gcgtctaaga
     2221 tctcttggct cagttgcgaa agcggacgct caaagccttt aagggcgata tgcaccaact
     2281 ggctttcaat catagaacca ttcaactcac gcgttttgcg ctccacatca tgcggaacgt
     2341 aaagctcaaa ttggccaagt ttcgcacttg cggcaaggta gcgagcaaat aacgcggcga
     2401 tcagtgcaag cacttcctgc ttatccggct gcgctaaacc atgctccgcc agtacgctgc
     2461 tgtgtagggc aatccgatat ttacgactgc aaagcgtatt gatggcgcta tttgcgctcg
     2521 gcaagctctg ctcaatccat gtagcgtggc tcgcaggctg taaccacggc aacaacgctt
     2581 gggataatgg cgtttgcggc atcacagggg taaagccgag ggaaagatcc tccccctcca
     2641 tcacaggatc gatgtcacag gcgatttggt tatacccatt ggttacgcac tcaaatacgc
     2701 gccgccaatc ccattgctcg ctgataattt gatggcttat caccccaagc actcgctctt
     2761 cgctccccaa actcaacaag caaaaactta gtgtggcttg cttggctaaa tccatcggct
     2821 gattttgcca tcgcacaaga tgttcaaacg cctcatccat tgactcaaca tgctcaaaat
     2881 ggatctcaag cggtgttggc ttcgccgagt acaaggttaa gccggatgcc tcatcaagca
     2941 catagcgtcg gtttaacact ggaaaatgat tgggcaactg actgagcgct gtgattaagc
     3001 gcgcgatatt cacttttccg ctcaatcgat aagcggtcgc atattgattg cgtccgtcac
     3061 catgtcgttg atgctgtcgc cagactcgct gttcaaactc actcaaggaa gccgatgaca
     3121 aggtaggtgg tgagagaggt tgactttgat tcggttgacc tactggttca acagagatcg
     3181 attgtcgctg aacatgcgct tggcactgtt tgcgatccac tttaccattc gcagaaagcg
     3241 gtaaagcctc taaagcaata aaccgactcg gaatatgcga agacggtagc gattgtttgg
     3301 caaactctcg taacgcctga ctcgatgctg attgctgagg tttaacgcta aataatgcgg
     3361 ctaaagcggt atctccatta gtatccgcat aatcgaccac caccacgctc gcgagcgccg
     3421 gatgagtttg cagctgcttt tcgatatccg gcagtgacac tcgtacccca cgaactttca
     3481 cataaccatt gatgcggcta gcaaaaatga tattgccgtc cgcgcggtag tagccttgat
     3541 cgcccgttcg aaacgcgcgc acagggtggc catgctcatc caatacggtg acaaaatcgg
     3601 tttgtttcag ttcgccgtct tcaagataac cttgcgctaa attgacccca gaggtgaaga
     3661 tacggccgac cacaccttgc ggtacatggc gttgtatctc atccataatg aaataacggt
     3721 ttcccgccaa cggccgacca tatgggatca cgctgacatc atctgccgtc agctcatgcc
     3781 agatgctcca aatcgtcgtc tcggtaggac cgcccaaaga gatcaaccgc ggcggatttg
     3841 aaccagcgcg taattgggcg atggtggcag gtttgatgta atccccccct tgggcaatca
     3901 gacgaagtga gtgtaattgc cctgcttgag tgcaagagag caacatctcc aagatagcgg
     3961 ggacggagac ccaaatcgtc acttgatgcc gctcaattaa gcgattccat tgcaacgcat
     4021 ctttttcttc atgcccagcg ggaagaacta acgtcgctcc gaagctcaag gtggcaaaga
     4081 gatcaaacac cgacatatca tgatgcaatg gcgtcactga catcaccaca tcctcactgg
     4141 tgagatgcca cgcttggcca gtttgaccaa tcacattcga ggtcgcctga ttattgacca
     4201 ccacgcactt aggtttgccc gtagtgccag aggtataaag ataataagcc gtttgttggc
     4261 tttggcttaa tcggcttaat tgatcgagtg gtgtaacgtc aggtactcca tcggcgaata
     4321 agacaggctc aatcaaggca tcaaaagcga tcacattgcc aaactcacag ggcttatcca
     4381 tcaccaccag atcggcgtga caattttcta aaaggtaatt cagacgctct ttgggagacg
     4441 cagcatcaat aggtacccag ataatccccg aaagtgcaga agccaaactg atgacgatat
     4501 gttcaacact gcgtggcaag caaatggcga gcacatttcc tgtggtcaac cctcgcgctt
     4561 tgagctgcca catcacgcgc tgaacctgct cacccaattg agcataagaa agggtttgtt
     4621 caccgcagat cacagcggtt ttatcctctg tgcggacaaa caattgctgc gctaacttgg
     4681 caagaaaatc gcaatcgtga ctggccgact catcgctatt aaaacggtag tgtgaaaggt
     4741 cgatacatgg ctcaagcggc gcggccaatg atgctgacga agtgatctga ctcaagcgat
     4801 gatgtaaggc acttaacatc tcgcggataa gctcagtctc taaaaccgct aaagcataat
     4861 caaagctgat gatgaggttt ttctgctcgt cgtaagttaa gcgaatatct aaagccactg
     4921 cggagtttgc gttaccccat cgaacagagt gacagcgtcc tctggattca gggttttcca
     4981 agacaaacca ttggttaaca caaccggcag caccagagct tgcggcgctt gattcatcaa
     5041 cagacggtta agatcgacgc cagaaaaagc aagatgctca agagcctcta gcatctcacg
     5101 ctgtagcttg ctcgcttggc tcagcaaact cagggtggat ttttcatgct ctaagatcac
     5161 aaaggatgac tcattgccat caatcgcatt actgcttgga attaataccg gaaaacccac
     5221 tcgcatcccg atttcggttg tccaatagga gagcacgtcc aagatggttg ctgtcagcaa
     5281 ggaattgaga aataagccat tttcaatgcc gcatcgattg agcttaccga cactctcttt
     5341 gggtatttgc aaactttcac gagcataacg agacgtagtg atcgtctcta atgcttgttt
     5401 ccaaggcagt gctggcggcg ggcaatcagg atgaagtttg cttttccaat acgcttcatc
     5461 ttgcgctttt ttggaggcga attgcggcga gatggactga gtatcacgag cattttgcac
     5521 cacctgagtt atatcgggtt cttcgcttcc tagtagtgca gcaagaatga gtgcatgggt
     5581 gcgaccatcg acaatcaaag catcaaagct ggtcaatacg atggagctga actcctcttg
     5641 ctcttctatt ggcagttgca ccacacagat ttgccagggc gagcgcgtta aatcatgcat
     5701 ccgctgctga tattgctgcc tgactggctc aaccgctaat aaggcttgtt cgcgggaaag
     5761 atgctgtaaa tcgatggctt gccaatttaa cgctatgcaa ggagagaccc actgaatcca
     5821 tttctcttga tcaatgcgag ttctcaaggc aggaatatgc tcaacgagat agagcagacg
     5881 gctatgcagt gactgagtgt cgatgtgacc tcgatactca cgaaactcat gcatcgcgac
     5941 gccgcctaag gcaatttggg ttgagcgacc tagcaagtaa gcttgttgta aaggggtcag
     6001 tggcatctcc tgaatcgact cgcggcgagc ataaccgagt tgcgcgtcaa tctgttgtac
     6061 gctttgctgc atcatctcag gatgcagcgc cacacagcgg atcaaatcaa cgtaatgcgc
     6121 gaaaagcgct gtgatgtcct tatcagcgaa gttttccatt cgcacatccc aattgagcaa
     6181 aatcccttca taagccggag caatttgcgc atcgagagtc acctgcgctc cctgcgaaat
     6241 cacccaattc atacgcccta aatgctgagt gacatgatcg gaaaagatct cctcgtctcg
     6301 catttccatg cctgaggtaa agactatcgg tgaacgctgc accccaccct gtttccgcga
     6361 taaatcgcgc atcacgctaa cccctgaata gctttcatgg cgaagtaatt gatgcagttg
     6421 gttagccgtt tgctgacaca ggcttaacag ggtctgagtc gttcccacat cggcgctaaa
     6481 aatcagcaaa ttggaaaaat cgccgatcgt gtgttcaata tccaaagagc gattgccgcg
     6541 atggaatgta ggtacattga gtcgaaattg tctctcttgg caagcattgg caatcacttg
     6601 tgaaaagagt gccaatgtca gttgggtcag tgtgagatga tgttgccgcg caacctccgc
     6661 caaccctttg cgctccactg gagtgaacca gtgtgcaaac ctttggctgt ttgcgctaac
     6721 ggcgtcggtt ggtacgggtt gataaggcaa acttggctcg gcgggaatcg tcgcaagacg
     6781 ctcttgccac catttcttat ccacctcttt gcgttttgcc aaagcacgat cggcttgctg
     6841 agcatcaaga tattggaaaa aagtcaccac atcagactca atgatctcta atcgatgctc
     6901 tatggcctct aaatagagtg aggtgagatc gtccaccaac agccgaaaac tttgtgcatc
     6961 acacgcaatc atatccgcat caatgtgtaa tcggtgtttg ccctcaggca acagagtcaa
     7021 gctgatctca atcgggtttc cctgagttaa atcgagcatc tggtgggtca ttcgctggcg
     7081 cttagtatgc acaaaagact ccacctcatc tggcttccat tgtgataggt catccacttt
     7141 aagctgatgg aaagttgaga gcggcaagat cttctgctgt ccatccttgg tgatcgctaa
     7201 acgtaacatg ggatgtttcg cgtacagcgc acgtaccgct tccgttagcg cctgtcgatt
     7261 taatgcttga ccatcaaatt cggcgtagag atgcgcggcc acaccatcga gcaagcagtc
     7321 gtgttgacgc cctagccaat aagccgcttg cattgctgtc atttctttca tctttaaacc
     7381 cacagattca tccctttact cggtacacat cgtcttgcaa cgcattaatg tgtaaatttt
     7441 agttaataat aatcattatc aattacatgt aaagagcgaa atcggtcagc ctcgagattg
     7501 aaaaagtcac gaacgcagcc aacacatcag aagctttgta ggaagggaaa agagaggggt
     7561 tggtaagccc ctgatggggc ttaccacatt aacaggcaag gtgaatgaaa tccgtgctga
     7621 gtcagaggtt aaaactcttc atccatcacc acatggcgct cttcgtggta cgcctcttcg
     7681 tttttaccgc gcttccaata aggaatggcg taaatcttat ctcttgcgat tcgatattca
     7741 ttgcgcaaaa ttttacgaca cgcaataacg ctctcatttt ctcctgccac aaaagcagaa
     7801 agcgactctg cgccttgcgg tactggcagt tgttcaatcg ccatcgccaa aacgggttgc
     7861 gcctgattag gatcgcgcac taaccactta atcaccatct gttctggatg ggagatatca
     7921 tgcttatctt cgatatcatc cacttcaaga aatacataac ctttggcctg actaggcatt
     7981 ttttctaaaa tggcactgat cgcaggcaca gcagagagat cgccagccat aatatgccaa
     8041 tctgctggct caataagagg gtctggccca ccgggaccta tcaaaccgag ttgtgaacca
     8101 gtttgagctt ttagcgccca tccaccaccc ggtgttcctt ctccatgcac aacaaaatcg
     8161 atatcaagct cattgctctg tgctcggtat tgtctaacgg tatacgctcg cggaaccggt
     8221 ttatgctctg gccaaatgac tttatcaccc tcacgaatcg gtaattggag tatgccactc
     8281 gcctgattag ggaaaaaaac cttaatgtgt gacccatttt gatcttcggg gaatccaatt
     8341 aaatcctcac cagtcagtgt cactcgaagt aggttttttg atacatattt tttacgcaca
     8401 aaatccagta atctcggata aacgcgctcg acttcgttac tcattctttc acctaattta
     8461 tcttatgcct tagccaacct tgctgggagt gtcattcact caatcctccc aacgttctgc
     8521 cccagttgaa aaacaatggt tcggccctgt aaacaatcaa ttcaaatgag aatgtatatc
     8581 attaaccaat tttacacaac tgtcgatcaa cttaaccaag ggagcccaga ttcttaggat
     8641 atggtttaac ctcgagagct cagctcaaga cttaaatgcg aacataaaaa aacgcctctc
     8701 agctgactta gaggcgttgt tttgtttcag tccatttgaa atatcattta gaaattcaac
     8761 tgcaccgatg caccaatcat gcgaggctgc tgtttaagtt ggtcaagcgt attattggtt
     8821 gagagataaa gcgttgtttt atcagaatcc aataagttag tggcatacaa ggttgctcgt
     8881 ccatgctcaa aaacataggc taactgagca ttggcaaccc aatatgagtc aatcgcaaat
     8941 ttttctgaat tgccactctc cgagaaatag cttccggtat aagccgcatt actactgaac
     9001 tcaaaccctt ggccaaaatc ataaagcaga ccaacattgg ctgacatttt cggtgctcga
     9061 ggcagctctt tggtgtttcc ggtggtttct ttgaactcgg ttttcaaaag ccctaggttg
     9121 gcaaaaagtt cgagtgaaga ggtcgcatac caacgtgatc cgatttcagc gccgtaagtg
     9181 ctcgcttcat caaggttagc gataaacaca tcaccactgg atgtggtttg cgtcatctgc
     9241 atactgtcaa aatcgttata gaaaaggtta gtcaacactt cgacagaatg gctgaaacgg
     9301 tgacgggtgt aaaactcata gttccaaatc gattcctgtt caaactcgta gggcctaaaa
     9361 cctgtaaatt gcatcgagtt aaaggctagt cctgccccac tcgcattgta acctttagcc
     9421 gctttaatcc cataggtctg cccttgcact ggtgtatatg ccacatcgag cttaggcaaa
     9481 aatacgctgg atgtttcatc gtaatcaagc ttgtatcttg ggtgcgagac gtttcgctta
     9541 acctgctctc tttcaaatcg gccagccaaa ttcacattga tagaaggcgt taacgcataa
     9601 gtgacttccg caaaaacgga tttggcttta gtgcgaccat ccatcggata tgcactggcc
     9661 gcatcaatgt acatatcatc ctgtgaagat tggtagtaac gcgccccaat cagcgtattc
     9721 acgctaccat ccagtgcgat atagcgtaat aacggttcga tatggaattc tttaccatcg
     9781 gtattgaaat cccctcggct attgggattg gtataacggt catagctgaa atcggcatac
     9841 accagattgt tttcaaaagt gaagaggtcg ttgagatgcc agataatatc ccacgccgtc
     9901 gtgaacgagg ctgtctcata aaccggtcgg aaggcttcgt tacccgccac attaatgttt
     9961 tctgtttgtg gcccacgaga atccatatga gagagcgtta acgtggtttt aaaaccatcc
    10021 agtgcggaag gttcgtacag cagcttaccg cgcaccgaat tcatctcgat ttttttagga
    10081 tcgcccgcgg gttcaaaagc agcaagatcg acaaaactat cccgcttctg ctgatcaaaa
    10141 ctcaaacgaa atgccaactc atcttgaata ataggtgcag agatcatacc cgctgtttgc
    10201 gaataatcgc tttcgccaat acctgctttt accgcacttt caaaatgatg agtagggtcg
    10261 ttagacttca tcacaatcgc gcccgccgag gtatttcgcc cttgaatgta gctctgtggc
    10321 cctaaataga tctccacttg ctgcatatcc cagagtgaac gagggccaaa agcaatttca
    10381 gaataagtca gcgaacgacc gtcaatcgac atatttaagc gaggtgatgt gccagcaaaa
    10441 ctggccaagc ccccaacgga aggccccgag ccatcgatac ctcgaatcgt gggcatattg
    10501 ttgctttgac ccgaatcgac aaggtttggg atcagttgta ggagatcatc aatctctgtt
    10561 gcgccgggtg ttctctcaat cgtgtcttga tcaaacactt cgacactcgc gctcgtctca
    10621 taaatgctgc gttgtgtttt ttcgccaatc acgaccaaca cgggcatttc ttgctcttga
    10681 ttactcgtat tctgcgtttc cgcataggca aaactgcccg tgaaaagccc catcatcatc
    10741 gccgacaagg tgtgcaattt aaactttttg ttctctgcaa cactgactcg cgctgggcat
    10801 aaaactgcca t
//
