BGC0000949 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000949 (Streptomyces griseus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	blactam,NRPS	1	65,257	A-500359 A/A-500359 B	NRPS:Type I	100%

BGC0000949 - Region 1 - NRPS,blactam

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Location: 1 - 65,257 nt. (total: 65,257 nt) Show pHMM detection rules used

Region on contig edge.

blactam: (BLS or CAS or tabtoxin)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 65,258
Label		BGC0000949

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000949	1.11	NRP	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000288	0.45	NRP	A-503083 A, A-503083 B, A-503083 E, A-503083 F	Streptomyces sp. SANK 62799
BGC0001191	0.41	Other	A-102395	Amycolatopsis sp. SANK 60206
BGC0000820	0.39	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0002508	0.34	Alkaloid	8-azaguanine	Streptomyces pathocidini
BGC0000025	0.34	Polyketide	avermectin	Streptomyces avermitilis
BGC0000410	0.30	NRP	pseudomonine	Pseudomonas fluorescens
BGC0002158	0.28	NRP, Polyketide	tenuazonic acid	Pyricularia oryzae 70-15
BGC0000825	0.26	Alkaloid	staurosporine	Streptomyces sp. TP-A0274
BGC0002347	0.26	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000949	1.00	NRP	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000820	0.71	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0000288	0.68	NRP	A-503083 A, A-503083 B, A-503083 E, A-503083 F	Streptomyces sp. SANK 62799
BGC0002508	0.67	Alkaloid	8-azaguanine	Streptomyces pathocidini
BGC0000410	0.63	NRP	pseudomonine	Pseudomonas fluorescens
BGC0002158	0.62	NRP, Polyketide	tenuazonic acid	Pyricularia oryzae 70-15
BGC0002071	0.61	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002347	0.60	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0002652	0.58	Other, Saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0001925	0.58	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 7863 - 65257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 22328 - 65257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BAI23334.1

AMP-binding (500..891): X

nrpys: Lys, meSer

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFESGGVGK
Nearest Stachelhaus code(s):: meSer DVFESGGVAK (79% 8Å match); Lys DVFESGGVAK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)