BGC0000949 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000949 (Streptomyces griseus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	blactam,NRPS	1	65,257	High	A-500359 A/A-500359 B	NRPS:Type I

BGC0000949 - Region 1 - NRPS,blactam

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Location: 1 - 65,257 nt. (total: 65,257 nt) Show pHMM detection rules used

Region on contig edge.

blactam: (BLS or CAS or tabtoxin)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 65,258
Label		BGC0000949

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

BAI23317.1: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

BAI23324.1: aldehyde oxidase and xanthine dehydrogenase

smcogs: SMCOG1293: aldehyde oxidase and xanthine dehydrogenase

Transferases: methyltransferase transferase

BAI23331.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

BAI23332.1: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

BAI23336.1: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: dehydratase

BAI23320.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

BAI23330.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase

BAI23334.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

BAI23335.1: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000949.5	1.08	NRPS	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000288.5	0.47	NRPS	A-503083 A, A-503083 B, A-503083 E, A-503083 F	Streptomyces sp. SANK 62799
BGC0002135.2	0.29	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.29	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.29	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.28	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.27	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.27	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002174.2	0.26	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0000825.5	0.26	other (other)	staurosporine	Streptomyces sp. TP-A0274

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000949.5	0.99	NRPS	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000288.5	0.69	NRPS	A-503083 A, A-503083 B, A-503083 E, A-503083 F	Streptomyces sp. SANK 62799
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.61	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002174.2	0.60	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0002071.2	0.59	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 7863 - 65257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 22328 - 65257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BAI23334.1: X

AMP-binding (500..891): X

nrpys: meSer, Lys

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFESGGVGK
Nearest Stachelhaus code(s):: meSer DVFESGGVAK (79% 8Å match); Lys DVFESGGVAK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor